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Edwin Deitch

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Gregory Tiesi; Jacquelyn N Tomaio; Leonard Mason; David Palange; Diego Reino; Edwin A Deitch
Early trauma-hemorrhage-induced splenic and thymic apoptosis is gut-mediated and toll-like receptor 4-dependent.
Gal Levy; Yong Qin; Luis Ulloa; Dazhong Xu; Vamsi Alli; Benjamin T J Chandler; Wei Dong; Eleonora Feketova; Jordan E Fishman; Edwin A Deitch
Parasympathetic stimulation via the vagus nerve prevents systemic organ dysfunction by abrogating gut injury and lymph toxicity in trauma and hemorrhagic shock.
Jordan E Fishman; Gal Levy; Qu Lu; Sharvil Sheth; Vamsi Alli; Edwin A Deitch
Oxidative modification of the intestinal mucus layer is a critical but unrecognized component of trauma hemorrhagic shock-induced gut barrier failure.

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2013: Gregory Tiesi; Jacquelyn N Tomaio; Leonard Mason; David Palange; Diego Reino; Edwin A Deitch
Early trauma-hemorrhage-induced splenic and thymic apoptosis is gut-mediated and toll-like receptor 4-dependent.
Shock (Augusta, Ga.) 2013;39(6):507-13.
2013: Gal Levy; Yong Qin; Luis Ulloa; Dazhong Xu; Vamsi Alli; Benjamin T J Chandler; Wei Dong; Eleonora Feketova; Jordan E Fishman; Edwin A Deitch
Parasympathetic stimulation via the vagus nerve prevents systemic organ dysfunction by abrogating gut injury and lymph toxicity in trauma and hemorrhagic shock.
Shock (Augusta, Ga.) 2013;39(1):39-44.
2013: Jordan E Fishman; Gal Levy; Qu Lu; Sharvil Sheth; Vamsi Alli; Edwin A Deitch
Oxidative modification of the intestinal mucus layer is a critical but unrecognized component of trauma hemorrhagic shock-induced gut barrier failure.
American journal of physiology. Gastrointestinal and liver physiology 2013;304(1):G57-63.
2012: Edwin A Deitch
Gut-origin sepsis: evolution of a concept.
The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 2012;10(6):350-6.
2012: Xiaofa Qin; Therese Rider; Susan M Sharpe; Sharvil U Sheth; Patrick Tso; Wei Dong; Ronald J Jandacek; David C Palange; Edwin A Deitch
Role of lipase-generated free fatty acids in converting mesenteric lymph from a noncytotoxic to a cytotoxic fluid.
American journal of physiology. Gastrointestinal and liver physiology 2012;303(8):G969-78.
2012: Gal Levy; Alicia Mohr; Dave Palange; Luis Ulloa; Gergely Vida; Da-zhong Xu; Wei Dong; Jordan E Fishman; Edwin A Deitch
Vagal nerve stimulation modulates gut injury and lung permeability in trauma-hemorrhagic shock.
The journal of trauma and acute care surgery 2012;73(2):338-42; discussion 342.
2012: Caron Hong; Qi Lu; Vadim Pisarenko; Da-Zhong Xu; Chunxiang Zhang; Margaret Brown; Yunhui Cheng; Edwin A Deitch; Danielle Doucet; Ellise S. Delphin
Systemic inflammatory response does not correlate with acute lung injury associated with mechanical ventilation strategies in normal lungs.
Anesthesia and analgesia 2012;115(1):118-21.
2012: Diego C Reino; Sharvil U Sheth; Luis Ulloa; Da Zhong Xu; Rena Feinman; Eleonora Feketeova; Qi Lu; David Palange; Geber Peña; Robert P Bonitz; Antonio De Maio; Edwin A Deitch
Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming.
Shock (Augusta, Ga.) 2012;38(1):107-14.
2011: Gergely Vida; Edwin A Deitch; Maria del Rocio Thompson-Bonilla; Alexandre Kanashiro; David Palange; Geber Peña; Luis Ulloa
β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(12):4476-85.
2011: György Haskó; Balázs Koscsó; Rachna Chandra; Balázs Csóka; Edwin A Deitch; Pál Gergely; Pál Pacher; Rolando H Rolandelli; Zoltán Spolarics; Linda F Thompson; László Virág; Zoltán H Németh
Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(8):4256-67.
2011: Justin T Sambol; Edwin A Deitch; Wei Dong; Garima Dosi; Mingshan Jiang; Marlon A Lee; Atsuko Yatani
Mesenteric lymph from rats with trauma-hemorrhagic shock causes abnormal cardiac myocyte function and induces myocardial contractile dysfunction.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;111(3):799-807.
2011: Edwin A Deitch; Wei Dong; Eleonora Feketeova; Qi Lu; David Palange; Xiaofa Qin; Sharvil U Sheth; Gregory Tiesi; Dazhong Xu; Rena Feinman
Anticoagulants influence the in vitro activity and composition of shock lymph but not its in vivo activity.
Shock (Augusta, Ga.) 2011;36(2):177-83.
2011: Bolin Cai; Edwin A Deitch; Weihong Dong; Susan Sharpe; Luis Ulloa
Survival and inflammatory responses in experimental models of hemorrhage.
The Journal of surgical research 2011;169(2):257-66.
2011: Geber Peña; Laura Ramos; Bolin Cai; Edwin A Deitch; Gergely Vida; Luis Ulloa
Cholinergic regulatory lymphocytes re-establish neuromodulation of innate immune responses in sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(2):718-25.
2011: Rachna Chandra; Stephanie Federici; Zoltán H Németh; Béla Horváth; Pál Pacher; György Haskó; Edwin A Deitch; Zoltán Spolarics
Female X-chromosome mosaicism for NOX2 deficiency presents unique inflammatory phenotype and improves outcome in polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(11):6465-73.
2011: Kolenkode B Kannan; Iriana Colorado; Diego Reino; David Palange; Qi Lu; Xiaofa Qin; Billy Abungu; Anthony C Watkins; Francis J Caputo; Da-Zhong Xu; Gregg L Semenza; Edwin A Deitch; Rena Feinman
Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury.
American journal of physiology. Gastrointestinal and liver physiology 2011;300(5):G853-61.
2011: Gergely Vida; Geber Peña; Edwin A Deitch; Luis Ulloa
α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4340-6.
2011: Sergey B Zaets; Da-Zhong Xu; Qi Lu; Eleonora Feketova; Tamara L Berezina; Inga V Malinina; Edwin A Deitch; Eva H Olsen
Recombinant factor XIII mitigates hemorrhagic shock-induced organ dysfunction.
The Journal of surgical research 2011;166(2):e135-42.
2011: Yong Qin; Lauriston M Prescott; Edwin A Deitch; Vicki L Kaiser
Heparin use in a rat hemorrhagic shock model induces biologic activity in mesenteric lymph separate from shock.
Shock (Augusta, Ga.) 2011;35(4):411-21.
2011: Xiaofa Qin; Sharvil U Sheth; Susan M Sharpe; Wei Dong; Qi Lu; Dazhong Xu; Edwin A Deitch
The mucus layer is critical in protecting against ischemia-reperfusion-mediated gut injury and in the restitution of gut barrier function.
Shock (Augusta, Ga.) 2011;35(3):275-81.
2011: Qi Lu; Da-Zhong Xu; Susan Sharpe; Danielle Doucet; Vadim Pisarenko; Marlon Lee; Edwin A Deitch
The anatomic sites of disruption of the mucus layer directly correlate with areas of trauma/hemorrhagic shock-induced gut injury.
The Journal of trauma 2011;70(3):630-5.
2011: Michael Condon; Maheswari Senthil; Da-Zhong Xu; Leonard Mason; Sharvil U Sheth; Zoltan Spolarics; Eleonora Feketova; George W Machiedo; Edwin A Deitch
Intravenous injection of mesenteric lymph produced during hemorrhagic shock decreases RBC deformability in the rat.
The Journal of trauma 2011;70(2):489-95.
2011: Diego C Reino; Sharvil U Sheth; Da Zhong Xu; Robert P Bonitz; Benjamin Chandler; Iriana Colorado; Edwin A Deitch; Danielle Doucet; Kolenkode B Kannan; Qi Lu; David Palange; Vadim Pisarenko; Madhuri Ramanathan; Rena Feinman
Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice.
PloS one 2011;6(8):e14829.
2010: Susan M Sharpe; Xiaofa Qin; Qi Lu; Eleonora Feketeova; David C Palange; Wei Dong; Sharvil U Sheth; Marlon A Lee; Diego Reino; Da-Zhong Xu; Edwin A Deitch
Loss of the intestinal mucus layer in the normal rat causes gut injury but not toxic mesenteric lymph nor lung injury.
Shock (Augusta, Ga.) 2010;34(5):475-81.
2010: Edwin A Deitch
Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction.
Annals of the New York Academy of Sciences 2010;1207 Suppl 1():E103-11.
2010: Rena Feinman; Edwin A Deitch; Anthony C Watkins; Billy Abungu; Iriana Colorado; Kolenkode B Kannan; Sharvil U Sheth; Francis J Caputo; Qi Lu; Madhuri Ramanathan; Shirhan Attan; Chirag D Badami; Danielle Doucet; Dimitrios Barlos; MARTA BOSCH; Gregg L Semenza; Da-Zhong Xu
HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(4):G833-43.
2010: Rachna Chandra; Stephanie Federici; György Haskó; Edwin A Deitch; Zoltán Spolarics
Female X-chromosome mosaicism for gp91phox expression diversifies leukocyte responses during endotoxemia.
Critical care medicine 2010;38(10):2003-10.
2010: Geber Peña; Bolin Cai; Jun Liu; Esmerij P van der Zanden; Edwin A Deitch; Wouter J de Jonge; Luis Ulloa
Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis.
European journal of immunology 2010;40(9):2580-9.
2010: Alicia M Mohr; Robert F Lavery; Ziad C Sifri; Devashish J Anjaria; Robert Koernig; Edwin A Deitch; David H Livingston
Gender differences in glucose variability after severe trauma.
The American surgeon 2010;76(8):896-902.
2010: Geber Peña; Bolin Cai; Edwin A Deitch; Luis Ulloa
JAK2 inhibition prevents innate immune responses and rescues animals from sepsis.
Journal of molecular medicine (Berlin, Germany) 2010;88(8):851-9.
2010: Leonóra Himer; Balázs Csóka; Zsolt Selmeczy; Balázs Koscsó; Tímea Pócza; Pal Pacher; Zoltán H Németh; Edwin A Deitch; E Sylvester Vizi; Bruce N Cronstein; György Haskó
Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(8):2631-40.
2010: WeiHong Dong; Bolin Cai; Geber Peña; Vadim Pisarenko; Gergely Vida; Danielle Doucet; Marlon Lee; Susan Sharpe; Qi Lu; Da-Zhong Xu; Laura Ramos; Edwin A Deitch; Luis Ulloa
Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage.
Shock (Augusta, Ga.) 2010;34(2):205-13.
2010: Edwin A Deitch; Luis Ulloa
Fat and the gut: more than empty calories.
Critical care medicine 2010;38(7):1608-9.
2010: Laura Ramos; Geber Peña; Bolin Cai; Edwin A Deitch; Luis Ulloa
Mast cell stabilization improves survival by preventing apoptosis in sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):709-16.
2010: Balázs Csóka; Zoltán H Németh; Peter Rosenberger; Holger K Eltzschig; Zoltán Spolarics; Pal Pacher; Zsolt Selmeczy; Balázs Koscsó; Leonóra Himer; E Sylvester Vizi; Michael R Blackburn; Edwin A Deitch; György Haskó
A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):542-50.
2010: Marie-Carmelle Elie-Turenne; Helen Fernandes; José R Mediavilla; Marnie Rosenthal; Barun Mathema; Ashima Singh; Tiffany R Cohen; Kimmerle A Pawar; Hosseinali Shahidi; Barry N Kreiswirth; Edwin A Deitch
Prevalence and characteristics of Staphylococcus aureus colonization among healthcare professionals in an urban teaching hospital.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 2010;31(6):574-80.
2010: Caron Hong; Da-Zhong Xu; Qi Lu; Yunhui Cheng; Vadim Pisarenko; Danielle Doucet; Margaret Brown; Seena Aisner; Chunxiang Zhang; Edwin A Deitch; Ellise S. Delphin
Low tidal volume and high positive end-expiratory pressure mechanical ventilation results in increased inflammation and ventilator-associated lung injury in normal lungs.
Anesthesia and analgesia 2010;110(6):1652-60.
2010: Sharvil U Sheth; Qi Lu; Kate Twelker; Susan M Sharpe; Xiaofa Qin; Diego C Reino; Marlon A Lee; Da-Zhong Xu; Edwin A Deitch
Intestinal mucus layer preservation in female rats attenuates gut injury after trauma-hemorrhagic shock.
The Journal of trauma 2010;68(2):279-88.
2010: Bolin Cai; Edwin A Deitch; Luis Ulloa
Novel insights for systemic inflammation in sepsis and hemorrhage.
Mediators of inflammation 2010;2010():642462.
2010: Danielle Doucet; Chirag Badami; David Palange; R Paul Bonitz; Qi Lu; Da-Zhong Xu; Kolenkode B Kannan; Iriana Colorado; Rena Feinman; Edwin A Deitch
Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats.
PloS one 2010;5(2):e9421.
2010: Danielle R Doucet; R Paul Bonitz; Rena Feinman; Iriana Colorado; Mahdury Ramanathan; Eleonora Feketeova; Michael Condon; George W Machiedo; Carl J Hauser; Da-Zhong Xu; Edwin A Deitch
Estrogenic hormone modulation abrogates changes in red blood cell deformability and neutrophil activation in trauma hemorrhagic shock.
The Journal of trauma 2010;68(1):35-41.
2009: Steve W Wang; Chirag D Badami; Edwin A Deitch
The use of barbiturate coma as salvage therapy in a postoperative Jehovah's Witness patient with life-threatening anemia.
The American surgeon 2009;75(12):1175-8.
2009: Bolin Cai; Fei Chen; Yan Ji; Levente Kiss; Wouter J de Jonge; Concepcion Conejero-Goldberg; Csaba Szabó; Edwin A Deitch; Luis Ulloa
Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation.
Journal of cellular and molecular medicine 2009;13(9B):3774-85.
2009: Yunhui Cheng; Xiaojun Liu; Jian Yang; Ying Lin; Da-Zhong Xu; Qi Lu; Edwin A Deitch; Yuqing Huo; Ellise S. Delphin; Chunxiang Zhang
MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation.
Circulation research 2009;105(2):158-66.
2009: Bolin Cai; Edwin A Deitch; Daniel Grande; Luis Ulloa
Anti-inflammatory resuscitation improves survival in hemorrhage with trauma.
The Journal of trauma 2009;66(6):1632-9; discussion 1639-40.
2009: Sergey B Zaets; Da-Zhong Xu; Qi Lu; Eleonora Feketova; Tamara L Berezina; Maryann Gruda; Inga V Malinina; Edwin A Deitch; Eva H N Olsen
Recombinant factor XIII diminishes multiple organ dysfunction in rats caused by gut ischemia-reperfusion injury.
Shock (Augusta, Ga.) 2009;31(6):621-6.
2009: Da-Zhong Xu; Sergey B Zaets; Ruihua Chen; Qi Lu; Harini Rajan; Xiaoman Yang; John Zhang; Eleonora Feketova; Nancy Bogdan; Edwin A Deitch; Yang Cao
Elimination of C5aR prevents intestinal mucosal damage and attenuates neutrophil infiltration in local and remote organs.
Shock (Augusta, Ga.) 2009;31(5):493-9.
2009: Bolin Cai; Michael Brunner; Haichao Wang; Ping Wang; Edwin A Deitch; Luis Ulloa
Ethyl pyruvate improves survival in awake hemorrhage.
Journal of molecular medicine (Berlin, Germany) 2009;87(4):423-33.
2009: George W Machiedo; Sergey B Zaets; Tamara L Berezina; Da-Zhong Xu; Eleonora Feketova; Zoltan Spolarics; Edwin A Deitch
Trauma-hemorrhagic shock-induced red blood cell damage leads to decreased microcirculatory blood flow.
Critical care medicine 2009;37(3):1000-10.
2009: Dimtrios Barlos; Edwin A Deitch; Anthony C Watkins; Francis J Caputo; Qi Lu; Billy Abungu; Iriana Colorado; Da-Zhong Xu; Rena Feinman
Trauma-hemorrhagic shock-induced pulmonary epithelial and endothelial cell injury utilizes different programmed cell death signaling pathways.
American journal of physiology. Lung cellular and molecular physiology 2009;296(3):L404-17.
2009: Balázs Csóka; Zoltán H Németh; Partha Mukhopadhyay; Zoltán Spolarics; Mohanraj Rajesh; Stephanie Federici; Edwin A Deitch; Sándor Bátkai; Pal Pacher; György Haskó
CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis.
PloS one 2009;4(7):e6409.
2009: Luis Ulloa; Michael Brunner; Laura Ramos; Edwin A Deitch
Scientific and clinical challenges in sepsis.
Current pharmaceutical design 2009;15(16):1918-35.
2009: Luis Ulloa; Edwin A Deitch
Neuroimmune perspectives in sepsis.
Critical care (London, England) 2009;13(2):133.
2009: Justin T Sambol; Marlon A Lee; Francis J Caputo; Kentaro Kawai; Chirag Badami; Tomoko Kawai; Edwin A Deitch; Atsuko Yatani
Mesenteric lymph duct ligation prevents trauma/hemorrhage shock-induced cardiac contractile dysfunction.
Journal of applied physiology (Bethesda, Md. : 1985) 2009;106(1):57-65.
2008: Chirag D Badami; Maheswari Senthil; Francis J Caputo; Bobby J Rupani; Danielle Doucet; Vadim Pisarenko; Da-Zhong Xu; Qi Lu; Rena Feinman; Edwin A Deitch
Mesenteric lymph duct ligation improves survival in a lethal shock model.
Shock (Augusta, Ga.) 2008;30(6):680-5.
2008: Kimberly Caprio; Michael Condon; Edwin A Deitch; Da-Zhong Xu; Eleonora Feketova; George W Machiedo
Alteration of alpha-spectrin ubiquitination after hemorrhagic shock.
American journal of surgery 2008;196(5):663-9.
2008: Levente Kiss; Edwin A Deitch; Csaba Szabó
Hydrogen sulfide decreases adenosine triphosphate levels in aortic rings and leads to vasorelaxation via metabolic inhibition.
Life sciences 2008;83(17-18):589-94.
2008: Balázs Csóka; Leonóra Himer; Zsolt Selmeczy; E Sylvester Vizi; Pal Pacher; Catherine Ledent; Edwin A Deitch; Zoltán Spolarics; Zoltán H Németh; György Haskó
Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3491-9.
2008: Edwin A Deitch; Hung Chu; Da Zhong Xu
Organ blood flow and the central hemodynamic response are better preserved in female, as opposed to the male rats, after trauma-hemorrhagic shock.
The Journal of trauma 2008;65(3):566-72.
2008: Dennis Vega; Chirag D Badami; Francis J Caputo; Anthony C Watkins; Qi Lu; Da Zhong Xu; Tamara L Berezina; Sergey B Zaets; Eleonora Feketeova; Edwin A Deitch
The influence of the type of resuscitation fluid on gut injury and distant organ injury in a rat model of trauma/hemorrhagic shock.
The Journal of trauma 2008;65(2):409-14; discussion 414-5.
2008: Edwin A Deitch; Maheswari Senthil; Margaret Brown; Francis J Caputo; Anthony C Watkins; Devashish Anjaria; Chirag Badami; Vadim Pisarenko; Danielle Doucet; Qi Lu; Eleonora Feketeova; Da-Zhong Xu
Trauma-shock-induced gut injury and the production of biologically active intestinal lymph is abrogated by castration in a large animal porcine model.
Shock (Augusta, Ga.) 2008;30(2):135-41.
2008: Cindy Lee; Da-Zhong Xu; Eleonora Feketeova; Zoltan Nemeth; Kolenkode B Kannan; György Haskó; Edwin A Deitch; Carl J Hauser
Calcium entry inhibition during resuscitation from shock attenuates inflammatory lung injury.
Shock (Augusta, Ga.) 2008;30(1):29-35.
2008: Anastasia Pyriochou; Gabor Olah; Edwin A Deitch; Csaba Szabó; Andreas Papapetropoulos
Inhibition of angiogenesis by the poly(ADP-ribose) polymerase inhibitor PJ-34.
International journal of molecular medicine 2008;22(1):113-8.
2008: Rachna Chandra; Erika Villanueva; Eleonora Feketova; George W Machiedo; György Haskó; Edwin A Deitch; Zoltán Spolarics
Endotoxemia down-regulates bone marrow lymphopoiesis but stimulates myelopoiesis: the effect of G6PD deficiency.
Journal of leukocyte biology 2008;83(6):1541-50.
2008: Devashish J Anjaria; Alicia M Mohr; Edwin A Deitch
Haemorrhagic shock therapy.
Expert opinion on pharmacotherapy 2008;9(6):901-11.
2008: Xiaofa Qin; Francis J Caputo; Da-Zhong Xu; Edwin A Deitch
Hydrophobicity of mucosal surface and its relationship to gut barrier function.
Shock (Augusta, Ga.) 2008;29(3):372-6.
2008: Anthony C Watkins; Francis J Caputo; Chirag Badami; Dimitrios Barlos; Da Zhong Xu; Qi Lu; Eleonora Feketeova; Edwin A Deitch
Mesenteric lymph duct ligation attenuates lung injury and neutrophil activation after intraperitoneal injection of endotoxin in rats.
The Journal of trauma 2008;64(1):126-30.
2008: Edwin A Deitch; Eleonora Feketeova; Qi Lu; Sergey B Zaets; Tamara L Berezina; George W Machiedo; Carl J Hauser; David H Livingston; Da-Zhong Xu
Resistance of the female, as opposed to the male, intestine to I/R-mediated injury is associated with increased resistance to gut-induced distant organ injury.
Shock (Augusta, Ga.) 2008;29(1):78-83.
2007: Maheswari Senthil; Anthony C Watkins; Dimitrios Barlos; Da-Zhong Xu; Qi Lu; Billy Abungu; Francis J Caputo; Rena Feinman; Edwin A Deitch
Intravenous injection of trauma-hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway.
Annals of surgery 2007;246(5):822-30.
2007: David G Greenhalgh; Jeffrey R Saffle; James Holmes; Richard L Gamelli; Tina L Palmieri; Jureta W Horton; Ronald G Tompkins; Daniel L Traber; David W Mozingo; Edwin A Deitch; Cleon W Goodwin; David N Herndon; James J Gallagher; Arthur P Sanford; James C Jeng; David Ahrenholz; Alice N Neely; Michael S O'Mara; Steven Wolf; Gary F Purdue; Warren L Garner; Charles J Yowler; Barbara A Latenser
American Burn Association consensus conference to define sepsis and infection in burns.
Journal of burn care & research : official publication of the American Burn Association 2007;28(6):776-90.
2007: Kiyoshi Itagaki; Jong K Yun; Jeremy A Hengst; Atsuko Yatani; Carl J Hauser; Zoltán Spolarics; Edwin A Deitch
Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism.
The Journal of pharmacology and experimental therapeutics 2007;323(1):186-91.
2007: Francis J Caputo; Bobby Rupani; Anthony C Watkins; Dimitrios Barlos; Dennis Vega; Maheswari Senthil; Edwin A Deitch
Pancreatic duct ligation abrogates the trauma hemorrhage-induced gut barrier failure and the subsequent production of biologically active intestinal lymph.
Shock (Augusta, Ga.) 2007;28(4):441-6.
2007: Balázs Csóka; Zoltán H Németh; Laszlo Virag; Pál Gergely; S Joseph Leibovich; Pal Pacher; Chun-Xiao Sun; Michael R Blackburn; E Sylvester Vizi; Edwin A Deitch; György Haskó
A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli.
Blood 2007;110(7):2685-95.
2007: Balázs Csóka; Zoltán H Németh; Zsolt Selmeczy; Balázs Koscsó; Pal Pacher; E Sylvester Vizi; Edwin A Deitch; György Haskó
Role of A(2A) adenosine receptors in regulation of opsonized E. coli-induced macrophage function.
Purinergic signalling 2007;3(4):447-52.
2007: Chirag D Badami; David H Livingston; Ziad C Sifri; Francis J Caputo; Larissa Bonilla; Alicia M Mohr; Edwin A Deitch
Hematopoietic progenitor cells mobilize to the site of injury after trauma and hemorrhagic shock in rats.
The Journal of trauma 2007;63(3):596-600; discussion 600-2.
2007: Edwin A Deitch; David H Livingston; Robert F Lavery; Sean F Monaghan; Advaith Bongu; George W Machiedo
Hormonally active women tolerate shock-trauma better than do men: a prospective study of over 4000 trauma patients.
Annals of surgery 2007;246(3):447-53; discussion 453-5.
2007: Rena Feinman; Edwin A Deitch; Virginie M Aris; Hung B Chu; Billy Abungu; Francis J Caputo; Anthony Galante; DaZhong Xu; Qi Lu; Iriana Colorado; Deanna L Streck; James J Dermody; Patricia Soteropoulos
Molecular signatures of trauma-hemorrhagic shock-induced lung injury: hemorrhage- and injury-associated genes.
Shock (Augusta, Ga.) 2007;28(3):360-8.
2007: Zoltán H Németh; David Bleich; Balázs Csóka; Pal Pacher; Jon G Mabley; Leonóra Himer; E Sylvester Vizi; Edwin A Deitch; Csaba Szabó; Bruce N Cronstein; György Haskó
Adenosine receptor activation ameliorates type 1 diabetes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(10):2379-88.
2007: Michael Condon; Eleonora Feketova; George W Machiedo; Edwin A Deitch; Zoltán Spolarics
Augmented erythrocyte band-3 phosphorylation in septic mice.
Biochimica et biophysica acta 2007;1772(5):580-6.
2007: Kentaro Kawai; Tomoko Kawai; Justin T Sambol; Da-Zhong Xu; Zhiqiang Yuan; Francis J Caputo; Chirag D Badami; Edwin A Deitch; Atsuko Yatani
Cellular mechanisms of burn-related changes in contractility and its prevention by mesenteric lymph ligation.
American journal of physiology. Heart and circulatory physiology 2007;292(5):H2475-84.
2007: Bobby Rupani; Francis J Caputo; Anthony C Watkins; Dennis Vega; Louis J Magnotti; Qi Lu; Da Zhong Xu; Edwin A Deitch
Relationship between disruption of the unstirred mucus layer and intestinal restitution in loss of gut barrier function after trauma hemorrhagic shock.
Surgery 2007;141(4):481-9.
2007: Ziad C Sifri; David Cohen; Preya Ananthakrishnan; Lai Wang; Vicki L Kaiser; Alicia M Mohr; Carl J Hauser; Pranela Rameshwar; Edwin A Deitch; David H Livingston
Sex hormones affect bone marrow dysfunction after trauma and hemorrhagic shock.
Critical care medicine 2007;35(3):864-9.
2007: Jeanette Wilmanski; Erika Villanueva; Edwin A Deitch; Zoltán Spolarics
Glucose-6-phosphate dehydrogenase deficiency and the inflammatory response to endotoxin and polymicrobial sepsis.
Critical care medicine 2007;35(2):510-8.
2007: György Haskó; Pal Pacher; Edwin A Deitch; E Sylvester Vizi
Shaping of monocyte and macrophage function by adenosine receptors.
Pharmacology & therapeutics 2007;113(2):264-75.
2006: Naohiko Fujiyoshi; Eleonora Feketeova; Qi Lu; Da-Zhong Xu; György Haskó; Edwin A Deitch
Amiloride moderates increased gut permeability and diminishes mesenteric lymph-mediated priming of neutrophils in trauma/hemorrhagic shock.
Surgery 2006;140(5):810-7.
2006: Edwin A Deitch; Saraswati D Dayal
Intensive care unit management of the trauma patient.
Critical care medicine 2006;34(9):2294-301.
2006: Edwin A Deitch; Preya Ananthakrishnan; David B Cohen; Da Zhong Xu; Eleonora Feketeova; Carl J Hauser
Neutrophil activation is modulated by sex hormones after trauma-hemorrhagic shock and burn injuries.
American journal of physiology. Heart and circulatory physiology 2006;291(3):H1456-65.
2006: Maheswari Senthil; Margaret Brown; Da-Zhong Xu; Qi Lu; Eleonora Feketeova; Edwin A Deitch
Gut-lymph hypothesis of systemic inflammatory response syndrome/multiple-organ dysfunction syndrome: validating studies in a porcine model.
The Journal of trauma 2006;60(5):958-65; discussion 965-7.
2006: Edwin A Deitch; Eleonora Feketeova; John M Adams; Raquel M Forsythe; Da-Zhong Xu; Kiyoshi Itagaki; Heinz Redl
Lymph from a primate baboon trauma hemorrhagic shock model activates human neutrophils.
Shock (Augusta, Ga.) 2006;25(5):460-3.
2006: Zoltán H Németh; Balázs Csóka; Jeanette Wilmanski; Dazhong Xu; Qi Lu; Catherine Ledent; Edwin A Deitch; Pal Pacher; Zoltán Spolarics; György Haskó
Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5616-26.
2006: György Haskó; Da-Zhong Xu; Qi Lu; Zoltán H Németh; Jondavid Jabush; Tamara L Berezina; Sergey B Zaets; Balázs Csóka; Edwin A Deitch
Adenosine A2A receptor activation reduces lung injury in trauma/hemorrhagic shock.
Critical care medicine 2006;34(4):1119-25.
2006: Edwin A Deitch
Surgical Infection Society presidential address: is the glass half full or half empty? Thoughts on the SIS and American surgery.
Surgical infections 2006;7(1):5-14.
2006: Atsuko Yatani; Da-Zhong Xu; Keiichi Irie; Kazunori Sano; Anoush Jidarian; Stephen F Vatner; Edwin A Deitch
Dual effects of mesenteric lymph isolated from rats with burn injury on contractile function in rat ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 2006;290(2):H778-85.
2006: Ziad C Sifri; Vicki L Kaiser; Preya Ananthakrishnan; Lai Wang; Alicia M Mohr; Carl J Hauser; Pranela Rameshwar; Edwin A Deitch; David H Livingston
Bone marrow failure in male rats following trauma/hemorrhagic shock (T/HS) is mediated by mesenteric lymph and modulated by castration.
Shock (Augusta, Ga.) 2006;25(1):12-6.
2006: Edwin A Deitch; DaZhong Xu; Vicki L Kaise
Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review.
Frontiers in bioscience : a journal and virtual library 2006;11():520-8.
2005: Zoltán H Németh; Carol S Lutz; Balázs Csóka; Edwin A Deitch; S Joseph Leibovich; William C Gause; Masahide Tone; Pal Pacher; E Sylvester Vizi; György Haskó
Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8260-70.
2005: Edwin A Deitch
Rodent models of intra-abdominal infection.
Shock (Augusta, Ga.) 2005;24 Suppl 1():19-23.
2005: Edwin A Deitch
The swinging pendulum of corticosteroid use in the intensive care unit: has it swung too far or not far enough?
Critical care medicine 2005;33(12):2842-3.
2005: Vicki L Kaiser; Ziad C Sifri; Maheswari Senthil; George S Dikdan; Qi Lu; Da-Zhong Xu; Edwin A Deitch
Albumin peptide: a molecular marker for trauma/hemorrhagic-shock in rat mesenteric lymph.
Peptides 2005;26(12):2491-9.
2005: Carl J Hauser; Kolenkode B Kannan; Edwin A Deitch; Kiyoshi Itagaki
Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils.
Biochemical and biophysical research communications 2005;336(4):1087-95.
2005: Naohiko Fujiyoshi; Edwin A Deitch; Eleonora Feketeova; Qi Lu; Tamara L Berezina; Sergey B Zaets; George W Machiedo; Da-Zhong Xu; György Haskó
Amiloride combined with small-volume resuscitation with hypertonic saline is superior in ameliorating trauma-hemorrhagic shock-induced lung injury in rats to the administration of either agent alone.
Critical care medicine 2005;33(11):2592-8.
2005: Tamara L Berezina; Sergey B Zaets; Damian Mole; Zoltán Spolarics; Edwin A Deitch; George W Machiedo
Mesenteric lymph duct ligation decreases red blood cell alterations caused by acute pancreatitis.
American journal of surgery 2005;190(5):800-4.
2005: Louis J Magnotti; Edwin A Deitch
Burns, bacterial translocation, gut barrier function, and failure.
The Journal of burn care & rehabilitation 2005;26(5):383-91.
2005: Hiroshi Homma; Edwin A Deitch; Eleonora Feketeova; Qi Lu; Tamara L Berezina; Sergey B Zaets; George W Machiedo; Da-Zhong Xu
Small volume resuscitation with hypertonic saline is more effective in ameliorating trauma-hemorrhagic shock-induced lung injury, neutrophil activation and red blood cell dysfunction than pancreatitic protease inhibition.
The Journal of trauma 2005;59(2):266-72.
2005: Cindy Lee; Da-Zhong Xu; Eleonora Feketeova; Kolenkode B Kannan; Zoltan Fekete; Edwin A Deitch; David H Livingston; Carl J Hauser
Store-operated calcium channel inhibition attenuates neutrophil function and postshock acute lung injury.
The Journal of trauma 2005;59(1):56-63; discussion 63.
2005: Jeanette Wilmanski; Muhammad Siddiqi; Edwin A Deitch; Zoltán Spolarics
Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages.
Journal of leukocyte biology 2005;78(1):85-94.
2005: Vicki L Kaiser; Ziad C Sifri; George S Dikdan; Tamara L Berezina; Sergey B Zaets; Qi Lu; Da-Zhong Xu; Edwin A Deitch
Trauma-hemorrhagic shock mesenteric lymph from rat contains a modified form of albumin that is implicated in endothelial cell toxicity.
Shock (Augusta, Ga.) 2005;23(5):417-25.
2005: Yoshihiko Suzuki; Qi Lu; Da-Zhong Xu; Csaba Szabó; György Haskó; Edwin A Deitch
Na+,K+-ATPase activity is inhibited in cultured intestinal epithelial cells by endotoxin or nitric oxide.
International journal of molecular medicine 2005;15(5):871-7.
2005: Hiroshi Homma; Erik Hoy; Da-Zhong Xu; Qi Lu; Rena Feinman; Edwin A Deitch
The female intestine is more resistant than the male intestine to gut injury and inflammation when subjected to conditions associated with shock states.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(3):G466-72.
2005: Preya Ananthakrishnan; David B Cohen; Da-Zhong Xu; Qi Lu; Eleonora Feketeova; Edwin A Deitch
Sex hormones modulate distant organ injury in both a trauma/hemorrhagic shock model and a burn model.
Surgery 2005;137(1):56-65.
2004: Qi Lu; Da-Zhong Xu; Marson T Davidson; György Haskó; Edwin A Deitch
Hemorrhagic shock induces endothelial cell apoptosis, which is mediated by factors contained in mesenteric lymph.
Critical care medicine 2004;32(12):2464-70.
2004: Cindy Lee; Da-Zhong Xu; Eleonora Feketeova; Kolenkode B Kannan; Jong K Yun; Edwin A Deitch; Zoltan Fekete; David H Livingston; Carl J Hauser
Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition.
The Journal of trauma 2004;57(5):955-60.
2004: David B Cohen; Louis J Magnotti; Qi Lu; Da-Zhong Xu; Tamara L Berezina; Sergey B Zaets; Carlos Alvarez; George W Machiedo; Edwin A Deitch
Pancreatic duct ligation reduces lung injury following trauma and hemorrhagic shock.
Annals of surgery 2004;240(5):885-91.
2004: Jadd Koury; Edwin A Deitch; Hiroshi Homma; Billy Abungu; Pranoti Gangurde; Michael Condon; Qi Lu; Da-Zhong Xu; Rena Feinman
Persistent HIF-1alpha activation in gut ischemia/reperfusion injury: potential role of bacteria and lipopolysaccharide.
Shock (Augusta, Ga.) 2004;22(3):270-7.
2004: Edwin A Deitch; Raquel M Forsythe; Devashish Anjaria; David H Livingston; Qi Lu; Da-Zhong Xu; Heinz Redl
The role of lymph factors in lung injury, bone marrow suppression, and endothelial cell dysfunction in a primate model of trauma-hemorrhagic shock.
Shock (Augusta, Ga.) 2004;22(3):221-8.
2004: Adena J Osband; Edwin A Deitch; Carl J Hauser; Qi Lu; Sergey B Zaets; Tamara L Berezina; George W Machiedo; Kapil K Rajwani; Da-Zhong Xu
Albumin protects against gut-induced lung injury in vitro and in vivo.
Annals of surgery 2004;240(2):331-9.
2004: Marson T Davidson; Edwin A Deitch; Qi Lu; Adena J Osband; Eleonora Feketeova; Zoltán H Németh; György Haskó; Da-Zhong Xu
A study of the biologic activity of trauma-hemorrhagic shock mesenteric lymph over time and the relative role of cytokines.
Surgery 2004;136(1):32-41.
2004: Marson T Davidson; Edwin A Deitch; Qi Lu; György Haskó; Billy Abungu; Zoltán H Németh; Sergey B Zaets; Lawrence D Gaspers; Andrew P Thomas; Da-Zhong Xu
Trauma-hemorrhagic shock mesenteric lymph induces endothelial apoptosis that involves both caspase-dependent and caspase-independent mechanisms.
Annals of surgery 2004;240(1):123-31.
2004: Zoltán H Németh; Edwin A Deitch; Marson T Davidson; Csaba Szabó; E Sylvester Vizi; György Haskó
Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cells.
Journal of cellular physiology 2004;200(1):71-81.
2004: Zoltán Spolarics; Michael Condon; Muhammad Siddiqi; George W Machiedo; Edwin A Deitch
Red blood cell dysfunction in septic glucose-6-phosphate dehydrogenase-deficient mice.
American journal of physiology. Heart and circulatory physiology 2004;286(6):H2118-26.
2004: George W Machiedo; Sergey B Zaets; Tamara L Berezina; Da-Zhong Xu; Zoltán Spolarics; Edwin A Deitch
Red blood cell damage after trauma-hemorrhage is modulated by gender.
The Journal of trauma 2004;56(4):837-44.
2004: Da-Zhong Xu; Qi Lu; Charles A Adams; Andrew C Issekutz; Edwin A Deitch
Trauma-hemorrhagic shock-induced up-regulation of endothelial cell adhesion molecules is blunted by mesenteric lymph duct ligation.
Critical care medicine 2004;32(3):760-5.
2004: Adena J Osband; Ziad C Sifri; Lai Wang; David Cohen; Carl J Hauser; Alicia M Mohr; Edwin A Deitch; David H Livingston
Small volume albumin administration protects against hemorrhagic shock-induced bone marrow dysfunction.
The Journal of trauma 2004;56(2):279-83.
2004: Edwin A Deitch; Han Ping Shi; Qi Lu; Eleonora Feketeova; Joan Skurnick; Da-Zhong Xu
Mesenteric lymph from burned rats induces endothelial cell injury and activates neutrophils.
Critical care medicine 2004;32(2):533-8.
2004: Zoltán H Németh; Hector R Wong; Kelli Odoms; Edwin A Deitch; Csaba Szabó; E Sylvester Vizi; György Haskó
Proteasome inhibitors induce inhibitory kappa B (I kappa B) kinase activation, I kappa B alpha degradation, and nuclear factor kappa B activation in HT-29 cells.
Molecular pharmacology 2004;65(2):342-9.
2004: Sergey B Zaets; Tamara L Berezina; Da-Zhong Xu; Qi Lu; David Cohen; Edwin A Deitch; George W Machiedo
Female sex hormones protect red blood cells from damage after trauma-hemorrhagic shock.
Surgical infections 2004;5(1):51-9.
2004: Edwin A Deitch; Qi Lu; Eleonora Feketeova; Carl J Hauser; Da-Zhong Xu
Intestinal bacterial overgrowth induces the production of biologically active intestinal lymph.
The Journal of trauma 2004;56(1):105-10.
2003: Zoltán H Németh; S Joseph Leibovich; Edwin A Deitch; Beáta Sperlágh; Laszlo Virag; E Sylvester Vizi; Csaba Szabó; György Haskó
Adenosine stimulates CREB activation in macrophages via a p38 MAPK-mediated mechanism.
Biochemical and biophysical research communications 2003;312(4):883-8.
2003: Sergey B Zaets; Tamara L Berezina; Da-Zhong Xu; Qi Lu; John Ricci; David Cohen; Preya Ananthakrishnan; Edwin A Deitch; George W Machiedo
Burn-induced red blood cell deformability and shape changes are modulated by sex hormones.
American journal of surgery 2003;186(5):540-6.
2003: David H Livingston; Devashish Anjaria; Jonathan Wu; Carl J Hauser; Victor Chang; Edwin A Deitch; Pranela Rameshwar
Bone marrow failure following severe injury in humans.
Annals of surgery 2003;238(5):748-53.
2003: Atsuko Yatani; Da-Zhong Xu; Song-Jung Kim; Stephen F Vatner; Edwin A Deitch
Mesenteric lymph from rats with thermal injury prolongs the action potential and increases Ca2+ transient in rat ventricular myocytes.
Shock (Augusta, Ga.) 2003;20(5):458-64.
2003: Joseph M Caruso; Eleonora Feketeova; Saraswati D Dayal; Carl J Hauser; Edwin A Deitch
Factors in intestinal lymph after shock increase neutrophil adhesion molecule expression and pulmonary leukosequestration.
The Journal of trauma 2003;55(4):727-33.
2003: Joseph M Caruso; Edwin A Deitch; Da-Zhong Xu; Qi Lu; Saraswati D Dayal
Gut injury and gut-induced lung injury after trauma hemorrhagic shock is gender and estrus cycle specific in the rat.
The Journal of trauma 2003;55(3):531-9.
2003: Adena J Osband; Edwin A Deitch; Qi Lu; Sergey B Zaets; Saraswati D Dayal; Biju Lukose; Da-Zhong Xu
The role of oxidant-mediated pathways in the cytotoxicity of endothelial cells exposed to mesenteric lymph from rats subjected to trauma-hemorrhagic shock.
Shock (Augusta, Ga.) 2003;20(3):269-73.
2003: Zoltán H Németh; S Joseph Leibovich; Edwin A Deitch; E Sylvester Vizi; Csaba Szabó; Gyorgy Hasko
cDNA microarray analysis reveals a nuclear factor-kappaB-independent regulation of macrophage function by adenosine.
The Journal of pharmacology and experimental therapeutics 2003;306(3):1042-9.
2003: Zoltán Spolarics; Muhammad Siddiqi; John H Siegel; Zenaida C Garcia; Dana S Stein; Thomas N Denny; Edwin A Deitch
Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients.
Critical care medicine 2003;31(6):1722-9.
2003: Michael Condon; Jiyoun E Kim; Edwin A Deitch; George W Machiedo; Zoltán Spolarics
Appearance of an erythrocyte population with decreased deformability and hemoglobin content following sepsis.
American journal of physiology. Heart and circulatory physiology 2003;284(6):H2177-84.
2003: Edwin A Deitch; Han Ping Shi; Qi Lu; Eleonora Feketeova; Da-Zhong Xu
Serine proteases are involved in the pathogenesis of trauma-hemorrhagic shock-induced gut and lung injury.
Shock (Augusta, Ga.) 2003;19(5):452-6.
2003: Edwin A Deitch; Han Ping Shi; Eleonora Feketeova; Carl J Hauser; Da-Zhong Xu
Hypertonic saline resuscitation limits neutrophil activation after trauma-hemorrhagic shock.
Shock (Augusta, Ga.) 2003;19(4):328-33.
2003: Sergey B Zaets; Tamara L Berezina; Claire Morgan; Mikio Kamiyama; Zoltán Spolarics; Da-Zhong Xu; Edwin A Deitch; George W Machiedo
Effect of trauma-hemorrhagic shock on red blood cell deformability and shape.
Shock (Augusta, Ga.) 2003;19(3):268-73.
2003: Zoltán H Németh; Edwin A Deitch; Csaba Szabó; György Haskó
Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells.
Immunology letters 2003;85(1):41-6.
2003: John M Adams; Charles A Adams; Da-Zhong Xu; Zoltan Fekete; Qi Lu; David H Livingston; Edwin A Deitch; Carl J Hauser
Sexual dimorphism in the activation of neutrophils by shock mesenteric lymph.
Surgical infections 2003;4(1):37-44.
2003: Sergey B Zaets; Tamara L Berezina; J Caruso; Da-Zhong Xu; Edwin A Deitch; George W Machiedo
Mesenteric lymph duct ligation prevents shock-induced RBC deformability and shape changes.
The Journal of surgical research 2003;109(1):51-6.
2002: Charles A Adams; Carl J Hauser; John M Adams; Zoltan Fekete; Da-Zhong Xu; Justin T Sambol; Edwin A Deitch
Trauma-hemorrhage-induced neutrophil priming is prevented by mesenteric lymph duct ligation.
Shock (Augusta, Ga.) 2002;18(6):513-7.
2002: Justin T Sambol; Jean White; Jureta W Horton; Edwin A Deitch
Burn-induced impairment of cardiac contractile function is due to gut-derived factors transported in mesenteric lymph.
Shock (Augusta, Ga.) 2002;18(3):272-6.
2002: Zoltán H Németh; Edwin A Deitch; Csaba Szabó; György Haskó
Hyperosmotic stress induces nuclear factor-kappaB activation and interleukin-8 production in human intestinal epithelial cells.
The American journal of pathology 2002;161(3):987-96.
2002: György Haskó; Edwin A Deitch; Csaba Szabó; Zoltán H Németh; E Sylvester Vizi
Adenosine: a potential mediator of immunosuppression in multiple organ failure.
Current opinion in pharmacology 2002;2(4):440-4.
2002: Zoltán H Németh; Edwin A Deitch; Qi Lu; Csaba Szabó; György Haskó
NHE blockade inhibits chemokine production and NF-kappaB activation in immunostimulated endothelial cells.
American journal of physiology. Cell physiology 2002;283(2):C396-403.
2002: Edwin A Deitch; Alexander Shorshtein; Jesse Houghton; Qi Lu; Dazhong Xu
Inducible nitric oxide synthase knockout mice are resistant to diet-induced loss of gut barrier function and intestinal injury.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2002;6(4):599-605.
2002: Amy M Liese; Muhammad Siddiqi; John H Siegel; Edwin A Deitch; Zoltán Spolarics
Attenuated monocyte IL-10 production in glucose-6-phosphate dehydrogenase-deficient trauma patients.
Shock (Augusta, Ga.) 2002;18(1):18-23.
2002: Zoltán H Németh; Edwin A Deitch; Csaba Szabó; Francisco Soriano; Pal Pacher; Zoltan Fekete; Carl J Hauser; György Haskó
Na+/H+ exchanger blockade inhibits enterocyte inflammatory response and protects against colitis.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(1):G122-32.
2002: Han Ping Shi; Edwin A Deitch; Zhong Da Xu; Qi Lu; Carl J Hauser
Hypertonic saline improves intestinal mucosa barrier function and lung injury after trauma-hemorrhagic shock.
Shock (Augusta, Ga.) 2002;17(6):496-501.
2002: Saraswati D Dayal; György Haskó; Qi Lu; Da-Zhong Xu; Joseph M Caruso; Justin T Sambol; Edwin A Deitch
Trauma/hemorrhagic shock mesenteric lymph upregulates adhesion molecule expression and IL-6 production in human umbilical vein endothelial cells.
Shock (Augusta, Ga.) 2002;17(6):491-5.
2002: Weidun Guo; Louis J Magnotti; Jiayi Ding; Qinghong Huang; Dazhong Xu; Edwin A Deitch
Influence of gut microflora on mesenteric lymph cytokine production in rats with hemorrhagic shock.
The Journal of trauma 2002;52(6):1178-85; disciussion 1185.
2002: Saraswati D Dayal; Carl J Hauser; Eleonora Feketeova; Zoltan Fekete; John M Adams; Qi Lu; Da-Zhong Xu; Sergey B Zaets; Edwin A Deitch
Shock mesenteric lymph-induced rat polymorphonuclear neutrophil activation and endothelial cell injury is mediated by aqueous factors.
The Journal of trauma 2002;52(6):1048-55; discussion 1055.
2002: György Haskó; Jon G Mabley; Zoltán H Németh; Pal Pacher; Edwin A Deitch; Csaba Szabó
Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation.
Molecular medicine (Cambridge, Mass.) 2002;8(5):283-9.
2002: Anne C Mosenthal; Robert F Lavery; Michael Addis; Sanjeev Kaul; Steven Ross; Robert Marburger; Edwin A Deitch; David H Livingston
Isolated traumatic brain injury: age is an independent predictor of mortality and early outcome.
The Journal of trauma 2002;52(5):907-11.
2002: Kiyoshi Itagaki; Kolenkode B Kannan; David H Livingston; Edwin A Deitch; Zoltan Fekete; Carl J Hauser
Store-operated calcium entry in human neutrophils reflects multiple contributions from independently regulated pathways.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):4063-9.
2002: Lucas Liaudet; Jon G Mabley; Pal Pacher; Laszlo Virag; Francisco Soriano; Anita Marton; György Haskó; Edwin A Deitch; Csaba Szabó
Inosine exerts a broad range of antiinflammatory effects in a murine model of acute lung injury.
Annals of surgery 2002;235(4):568-78.
2002: György Haskó; Edwin A Deitch; Zoltán H Németh; David G Kuhel; Csaba Szabó
Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages.
The Journal of pharmacology and experimental therapeutics 2002;301(1):103-10.
2002: Zoltán H Németh; Edwin A Deitch; Csaba Szabó; Zoltan Fekete; Carl J Hauser; György Haskó
Lithium induces NF-kappa B activation and interleukin-8 production in human intestinal epithelial cells.
The Journal of biological chemistry 2002;277(10):7713-9.
2002: Raquel M Forsythe; Da-Zhong Xu; Qi Lu; Edwin A Deitch
Lipopolysaccharide-induced enterocyte-derived nitric oxide induces intestinal monolayer permeability in an autocrine fashion.
Shock (Augusta, Ga.) 2002;17(3):180-4.
2002: Edwin A Deitch
Bacterial translocation or lymphatic drainage of toxic products from the gut: what is important in human beings?
Surgery 2002;131(3):241-4.
2002: Anne C Mosenthal; Dazhong Xu; Edwin A Deitch
Elemental and intravenous total parenteral nutrition diet-induced gut barrier failure is intestinal site specific and can be prevented by feeding nonfermentable fiber.
Critical care medicine 2002;30(2):396-402.
2002: Da-Zhong Xu; Qi Lu; Edwin A Deitch
Nitric oxide directly impairs intestinal barrier function.
Shock (Augusta, Ga.) 2002;17(2):139-45.
2002: Tamara L Berezina; Sergey B Zaets; Claire Morgan; Charles R Spillert; Mikio Kamiyama; Zoltán Spolarics; Edwin A Deitch; George W Machiedo
Influence of storage on red blood cell rheological properties.
The Journal of surgical research 2002;102(1):6-12.
2002: György Haskó; Csaba Szabó; Zoltán H Németh; Edwin A Deitch
Dopamine suppresses IL-12 p40 production by lipopolysaccharide-stimulated macrophages via a beta-adrenoceptor-mediated mechanism.
Journal of neuroimmunology 2002;122(1-2):34-9.
2001: John M Adams; Carl J Hauser; Charles A Adams; Da-Zhong Xu; David H Livingston; Edwin A Deitch
Entry of gut lymph into the circulation primes rat neutrophil respiratory burst in hemorrhagic shock.
Critical care medicine 2001;29(11):2194-8.
2001: Charles A Adams; Justin T Sambol; Da-Zhong Xu; Qi Lu; D N Granger; Edwin A Deitch
Hemorrhagic shock induced up-regulation of P-selectin expression is mediated by factors in mesenteric lymph and blunted by mesenteric lymph duct interruption.
The Journal of trauma 2001;51(4):625-31; discussion 631-2.
2001: Edwin A Deitch; Charles A Adams; Qi Lu; Da-Zhong Xu
Mesenteric lymph from rats subjected to trauma-hemorrhagic shock are injurious to rat pulmonary microvascular endothelial cells as well as human umbilical vein endothelial cells.
Shock (Augusta, Ga.) 2001;16(4):290-3.
2001: Devashish Anjaria; Pranela Rameshwar; Edwin A Deitch; Da-Zhong Xu; Charles A Adams; Raquel M Forsythe; Justin T Sambol; Carl J Hauser; David H Livingston
Hematopoietic failure after hemorrhagic shock is mediated partially through mesenteric lymph.
Critical care medicine 2001;29(9):1780-5.
2001: John M Adams; Carl J Hauser; David H Livingston; Robert F Lavery; Zoltan Fekete; Edwin A Deitch
Early trauma polymorphonuclear neutrophil responses to chemokines are associated with development of sepsis, pneumonia, and organ failure.
The Journal of trauma 2001;51(3):452-6; discussion 456-7.
2001: J Ding; Louis J Magnotti; Q Huang; Da-Zhong Xu; Michael Condon; Edwin A Deitch
Hypoxia combined with Escherichia coli produces irreversible gut mucosal injury characterized by increased intestinal cytokine production and DNA degradation.
Shock (Augusta, Ga.) 2001;16(3):189-95.
2001: J C Wu; David H Livingston; Carl J Hauser; Edwin A Deitch; Pranela Rameshwar
Trauma inhibits erythroid burst-forming unit and granulocyte-monocyte colony-forming unit growth through the production of TGF-beta1 by bone marrow stroma.
Annals of surgery 2001;234(2):224-32.
2001: Zoltan Fekete; Carl J Hauser; John M Adams; Charles A Adams; Raquel M Forsythe; György Haskó; Da-Zhong Xu; David H Livingston; Edwin A Deitch
Injury-enhanced calcium mobilization in circulating rat neutrophils models human PMN responses.
Shock (Augusta, Ga.) 2001;16(1):15-20.
2001: Zoltán H Németh; Francisco Soriano; Edwin A Deitch; Csaba Szabó; György Haskó
Inhibition of the Na(+)/H(+) antiporter suppresses IL-12 p40 production by mouse macrophages.
Biochimica et biophysica acta 2001;1539(3):233-42.
2001: Tamara L Berezina; Sergey B Zaets; Vyacheslav Leontjevich Kozhura; IS Novoderzhkina; AK Kirsanova; Edwin A Deitch; George W Machiedo
Morphologic changes of red blood cells during hemorrhagic shock replicate changes of aging.
Shock (Augusta, Ga.) 2001;15(6):467-70.
2001: John M Adams; Carl J Hauser; David H Livingston; Zoltan Fekete; Gyorgy Hasko; Raquel M Forsythe; Edwin A Deitch
The immunomodulatory effects of damage control abdominal packing on local and systemic neutrophil activity.
The Journal of trauma 2001;50(5):792-800.
2001: Edwin A Deitch
Role of the gut lymphatic system in multiple organ failure.
Current opinion in critical care 2001;7(2):92-8.
2001: Zoltán Spolarics; Muhammad Siddiqi; John H Siegel; Zenaida C Garcia; Dana S Stein; H Ong; David H Livingston; Thomas N Denny; Edwin A Deitch
Increased incidence of sepsis and altered monocyte functions in severely injured type A- glucose-6-phosphate dehydrogenase-deficient African American trauma patients.
Critical care medicine 2001;29(4):728-36.
2001: Charles A Adams; Da-Zhong Xu; Qi Lu; Edwin A Deitch
Factors larger than 100 kd in post-hemorrhagic shock mesenteric lymph are toxic for endothelial cells.
Surgery 2001;129(3):351-63.
2001: Joseph M Caruso; Da-Zhong Xu; Qi Lu; Saraswati D Dayal; Edwin A Deitch
The female gender protects against pulmonary injury after trauma hemorrhagic shock.
Surgical infections 2001;2(3):231-40.
2001: Carl J Hauser; Zoltan Fekete; John M Adams; M Garced; David H Livingston; Edwin A Deitch
PAF-mediated Ca2+ influx in human neutrophils occurs via store-operated mechanisms.
Journal of leukocyte biology 2001;69(1):63-8.
2001: Edwin A Deitch; C Adams; Qi Lu; Da-Zhong Xu
A time course study of the protective effect of mesenteric lymph duct ligation on hemorrhagic shock-induced pulmonary injury and the toxic effects of lymph from shocked rats on endothelial cell monolayer permeability.
Surgery 2001;129(1):39-47.
2000: John M Adams; Carl J Hauser; Zoltan Fekete; David H Livingston; Edwin A Deitch
G-protein receptor responses in trauma neutrophils.
The Journal of trauma 2000;49(6):1096-101.
2000: Y Suzuki; Edwin A Deitch; S Mishima; Qi Lu; Dazhong Xu
Inducible nitric oxide synthase gene knockout mice have increased resistance to gut injury and bacterial translocation after an intestinal ischemia-reperfusion injury.
Critical care medicine 2000;28(11):3692-6.
2000: Charles A Adams; Louis J Magnotti; Da-Zhong Xu; Qi Lu; Edwin A Deitch
Acute lung injury after hemorrhagic shock is dependent on gut injury and sex.
The American surgeon 2000;66(10):905-12; discussion 912-3.
2000: Christopher Bibbo; R A Barbieri; Edwin A Deitch; Robert E Brolin
Neutropenic enterocolitis in a trauma patient during antibiotic therapy for osteomyelitis.
The Journal of trauma 2000;49(4):760-3.
2000: György Haskó; David G Kuhel; J F Chen; Michael A Schwarzschild; Edwin A Deitch; Francisco Soriano; Anita Marton; Csaba Szabó
Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(13):2065-74.
2000: Justin T Sambol; Da-Zhong Xu; Charles A Adams; Louis J Magnotti; Edwin A Deitch
Mesenteric lymph duct ligation provides long term protection against hemorrhagic shock-induced lung injury.
Shock (Augusta, Ga.) 2000;14(3):416-9; discussion 419-20.
2000: Edwin A Deitch; Randi L Rutan
The challenges of children: the first 48 hours.
The Journal of burn care & rehabilitation 2000;21(5):424-30; quiz 431; discussion 423.
2000: György Haskó; David G Kuhel; Anita Marton; Z H Nemeth; Edwin A Deitch; Csaba Szabó
Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma.
Shock (Augusta, Ga.) 2000;14(2):144-9.
2000: Y Suzuki; Edwin A Deitch; S Mishima; W N Duràn; Da-Zhong Xu
Endotoxin-induced mesenteric microvascular changes involve iNOS-derived nitric oxide: results from a study using iNOS knock out mice.
Shock (Augusta, Ga.) 2000;13(5):397-403.
2000: Carl J Hauser; Zoltan Fekete; David H Livingston; J Adams; M Garced; Edwin A Deitch
Major trauma enhances store-operated calcium influx in human neutrophils.
The Journal of trauma 2000;48(4):592-7; discussion 597-8.
1999: Edwin A Deitch; Elliot Goodman
Prevention of multiple organ failure.
The Surgical clinics of North America 1999;79(6):1471-88.
1999: Louis J Magnotti; Da-Zhong Xu; Qi Lu; Edwin A Deitch
Gut-derived mesenteric lymph: a link between burn and lung injury.
Archives of surgery (Chicago, Ill. : 1960) 1999;134(12):1333-40; discussion 1340-1.
1999: Carl J Hauser; Zoltan Fekete; Elliot Goodman; E Kleinstein; David H Livingston; Edwin A Deitch
CXCR2 stimulation primes CXCR1 [Ca2+]i responses to IL-8 in human neutrophils.
Shock (Augusta, Ga.) 1999;12(6):428-37.
1999: Carl J Hauser; N Desai; Zoltan Fekete; David H Livingston; Edwin A Deitch
Priming of neutrophil [Ca2+]i signaling and oxidative burst by human fracture fluids.
The Journal of trauma 1999;47(5):854-8.
1999: Elliot Goodman; P Stricker; M Velavicius; R Fonseca; E Kleinstein; RF Lavery; Edwin A Deitch; Carl J Hauser; H H Simms
Role of granulocyte-macrophage colony-stimulating factor and its receptor in the genesis of acute respiratory distress syndrome through an effect on neutrophil apoptosis.
Archives of surgery (Chicago, Ill. : 1960) 1999;134(10):1049-54.
1999: Carl J Hauser; Zoltan Fekete; David H Livingston; Elliot Goodman; Edwin A Deitch
Integrated stimulation by CXC chemokines enhances PMN [Ca2+]i signaling in trauma and adult respiratory distress syndrome.
Surgery 1999;126(2):208-15.
1999: S Mishima; Dazhong Xu; Edwin A Deitch
Increase in endotoxin-induced mucosal permeability is related to increased nitric oxide synthase activity using the Ussing chamber.
Critical care medicine 1999;27(5):880-6.
1999: Da-Zhong Xu; Qi Lu; Richard Kubicka; Edwin A Deitch
The effect of hypoxia/reoxygenation on the cellular function of intestinal epithelial cells.
The Journal of trauma 1999;46(2):280-5.
1998: Jeffrey Upperman; Edwin A Deitch; W Guo; Qi Lu; Dazhong Xu
Post-hemorrhagic shock mesenteric lymph is cytotoxic to endothelial cells and activates neutrophils.
Shock (Augusta, Ga.) 1998;10(6):407-14.
1998: Carl J Hauser; Zoltan Fekete; David H Livingston; Edwin A Deitch
Chemokine stimulation of human neutrophil [Ca2+]i signaling in biologic environments.
Shock (Augusta, Ga.) 1998;10(5):324-8.
1998: Elliot Goodman; E Kleinstein; A M Fusco; D P Quinlan; RF Lavery; David H Livingston; Edwin A Deitch; Carl J Hauser
Role of interleukin 8 in the genesis of acute respiratory distress syndrome through an effect on neutrophil apoptosis.
Archives of surgery (Chicago, Ill. : 1960) 1998;133(11):1234-9.
1998: Louis J Magnotti; Jeffrey Upperman; Da-Zhong Xu; Qi Lu; Edwin A Deitch
Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock.
Annals of surgery 1998;228(4):518-27.
1998: G M Swank; Qi Lu; Da-Zhong Xu; M Michalsky; Edwin A Deitch
Effect of acute-phase and heat-shock stress on apoptosis in intestinal epithelial cells (Caco-2).
Critical care medicine 1998;26(7):1213-7.
1998: Edwin A Deitch
Animal models of sepsis and shock: a review and lessons learned.
Shock (Augusta, Ga.) 1998;9(1):1-11.
1998: S Mishima; Dazhong Xu; Qi Lu; Edwin A Deitch
The relationships among nitric oxide production, bacterial translocation, and intestinal injury after endotoxin challenge in vivo.
The Journal of trauma 1998;44(1):175-82.
1998: Dazhong Xu; Qi Lu; Edwin A Deitch
Elemental diet-induced bacterial translocation associated with systemic and intestinal immune suppression.
JPEN. Journal of parenteral and enteral nutrition 1998;22(1):37-41.
1997: S Mishima; Dazhong Xu; Qi Lu; Edwin A Deitch
Bacterial translocation is inhibited in inducible nitric oxide synthase knockout mice after endotoxin challenge but not in a model of bacterial overgrowth.
Archives of surgery (Chicago, Ill. : 1960) 1997;132(11):1190-5.
1997: M Katayama; Dazhong Xu; R D Specian; Edwin A Deitch
Role of bacterial adherence and the mucus barrier on bacterial translocation: effects of protein malnutrition and endotoxin in rats.
Annals of surgery 1997;225(3):317-26.
1997: Randi L Rutan; Edwin A Deitch; J P Waymack
Academic surgeons' knowledge of Food and Drug Administration regulations for clinical trials.
Archives of surgery (Chicago, Ill. : 1960) 1997;132(1):94-8.
1996: Da-Zhong Xu; Qi Lu; G M Swank; Edwin A Deitch
Effect of heat shock and endotoxin stress on enterocyte viability apoptosis and function varies based on whether the cells are exposed to heat shock or endotoxin first.
Archives of surgery (Chicago, Ill. : 1960) 1996;131(11):1222-8.
1996: Edwin A Deitch; Randi L Rutan; J P Waymack
Trauma, shock, and gut translocation.
New horizons (Baltimore, Md.) 1996;4(2):289-99.
1996: G M Swank; Edwin A Deitch
Role of the gut in multiple organ failure: bacterial translocation and permeability changes.
World journal of surgery 1996;20(4):411-7.
1995: W Guo; J Ding; Q Huang; T Jerrells; Edwin A Deitch
Alterations in intestinal bacterial flora modulate the systemic cytokine response to hemorrhagic shock.
The American journal of physiology 1995;269(6 Pt 1):G827-32.
1995: Edwin A Deitch; Y Haskel; N Cruz; Dazhong Xu; P R Kvietys
Caco-2 and IEC-18 intestinal epithelial cells exert bactericidal activity through an oxidant-dependent pathway.
Shock (Augusta, Ga.) 1995;4(5):345-50.
1995: Edwin A Deitch; S C Beck; N C Cruz; Antonio De Maio
Induction of heat shock gene expression in colonic epithelial cells after incubation with Escherichia coli or endotoxin.
Critical care medicine 1995;23(8):1371-6.
1995: Edwin A Deitch
Nutritional support of the burn patient.
Critical care clinics 1995;11(3):735-50.
1995: S C Beck; Charles N Paidas; Maria Lourdes Mooney; Edwin A Deitch; Antonio De Maio
Presence of the stress-inducible form of hsp-70 (hsp-72) in normal rat colon.
Shock (Augusta, Ga.) 1995;3(6):398-402.
1995: David H Livingston; A C Mosenthal; Edwin A Deitch
Sepsis and multiple organ dysfunction syndrome: a clinical-mechanistic overview.
New horizons (Baltimore, Md.) 1995;3(2):257-66.
1995: Edwin A Deitch; Dazhong Xu; M B Naruhn; D C Deitch; Qi Lu; A A Marino
Elemental diet and IV-TPN-induced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria.
Annals of surgery 1995;221(3):299-307.