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Donatella Del Bufalo

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Sergio Valente; Lucia Altucci; Rosaria Benedetti; Roberto Boggio; Donatella Del Bufalo; Salvatore Di Maro; Donatella Labella; Antonello Mai; Ciro Mercurio; Ettore Novellino; Daniela Secci; Maria Tardugno; Stefano Tomassi; Daniela Trisciuoglio; Sandro Cosconati
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells.
Daniela Trisciuoglio; Teresa De Luca; Marianna Desideri; Chiara Gabellini; Chengyu Liang; Augusto Orlandi; Daniela Passeri; Stefania Scarpino; Donatella Del Bufalo
Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth.
Y Ragazzoni; Daniela Secci; Antonio Candiloro; Simone Carradori; Maria Condello; T De Luca; Donatella Del Bufalo; Marianna Desideri; Chiara Gabellini; Stefania Meschini; R Nescatelli; Daniela Trisciuoglio
The thiazole derivative CPTH6 impairs autophagy.

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All Publications

2013: Sergio Valente; Lucia Altucci; Rosaria Benedetti; Roberto Boggio; Donatella Del Bufalo; Salvatore Di Maro; Donatella Labella; Antonello Mai; Ciro Mercurio; Ettore Novellino; Daniela Secci; Maria Tardugno; Stefano Tomassi; Daniela Trisciuoglio; Sandro Cosconati
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells.
ChemMedChem 2013;8(5):800-11.
2013: Daniela Trisciuoglio; Teresa De Luca; Marianna Desideri; Chiara Gabellini; Chengyu Liang; Augusto Orlandi; Daniela Passeri; Stefania Scarpino; Donatella Del Bufalo
Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth.
Neoplasia (New York, N.Y.) 2013;15(3):315-27.
2013: Y Ragazzoni; Daniela Secci; Antonio Candiloro; Simone Carradori; Maria Condello; T De Luca; Donatella Del Bufalo; Marianna Desideri; Chiara Gabellini; Stefania Meschini; R Nescatelli; Daniela Trisciuoglio
The thiazole derivative CPTH6 impairs autophagy.
Cell death & disease 2013;4():e524.
2012: Maria Rosaria Ricciardi; Maria Cristina Scerpa; Linda S Steelman; Agostino Tafuri; Simona Tavolaro; Twee Tsao; Maria Teresa Petrucci; Stephen L Abrams; Michael Andreeff; Paola Bergamo; Sabina Chiaretti; Ludovica Ciuffreda; Francesco Cognetti; Donatella Del Bufalo; Robin Foà; Marina Konopleva; Antonio Marchetti; Maria Grazia Mascolo; James A McCubrey; Michele Milella
Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies.
Journal of molecular medicine (Berlin, Germany) 2012;90(10):1133-44.
2012: simona caporali; Marina Ciomei; Ester Alvino; Enzo Bonmassar; Maria G Brasca; Donatella Del Bufalo; Marianna Desideri; Alessia I Esposito; Lauretta Levati; Ulrich Pfeffer; Stefania D'Atri
Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.
Biochemical pharmacology 2012;84(5):598-611.
2012: Ludovica Ciuffreda; Francesco Cognetti; Ruggero De Maria; Donatella Del Bufalo; Marianna Desideri; Cristina Di Sanza; Adriana Eramo; Italia Falcone; James A McCubrey; Andrea Anichini; Paola Bergamo; Francesca Biagioni; Giovanni Blandino; Ursula Cesta Incani; Augusto Orlandi; Daniela Passeri; Maria Rosaria Ricciardi; Kanaga Sabapathy; Giovanni Sette; Agostino Tafuri; Michele Milella
The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms.
Journal of molecular medicine (Berlin, Germany) 2012;90(6):667-79.
2012: Daniela Trisciuoglio; Bruna Bizzarri; Adriana Bolasco; Simone Carradori; Chiara Cavaliere; Igea D'Agnano; Marianna Desideri; patrizia filetici; Chiara Gabellini; Giovanna Maresca; Riccardo Nescatelli; Andrea Pelosi; Ylenia Ragazzoni; Lucia Ricci-Vitiani; Maria Giulia Rizzo; Daniela Secci; Donatella Del Bufalo
CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(2):475-86.
2011: Donatella Del Bufalo; A Bagnato; A Fusco; M Milella
Lost in translation: bridging the gap between cancer research and effective therapies.
Cell death and differentiation 2011;18(6):1082-4.
2011: Daniela Trisciuoglio; Chiara Gabellini; Marianna Desideri; Y Ragazzoni; T De Luca; E Ziparo; Donatella Del Bufalo
Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells.
Cell death and differentiation 2011;18(6):1024-35.
2010: Alessio Paone; Roberta Galli; Chiara Gabellini; Dmitriy Lukashev; Donatella Starace; Agnes Gorlach; Paola De Cesaris; Elio Ziparo; Donatella Del Bufalo; Michail V Sitkovsky; Antonio Filippini; Anna Riccioli
Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha.
Neoplasia (New York, N.Y.) 2010;12(7):539-49.
2009: Giulia Fontemaggi; Stefania Dell'Orso; Daniela Trisciuoglio; Tal Shay; Elisa Melucci; Francesco Fazi; Irene Terrenato; Marcella Mottolese; Paola Muti; Eytan Domany; Donatella Del Bufalo; Sabrina Strano; Giovanni Blandino
The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis.
Nature structural & molecular biology 2009;16(10):1086-93.
2009: Chiara Gabellini; Daniela Trisciuoglio; Marianna Desideri; Antonio Candiloro; Ylenia Ragazzoni; Augusto Orlandi; Gabriella Zupi; Donatella Del Bufalo
Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression.
European journal of cancer (Oxford, England : 1990) 2009;45(14):2618-27.
2009: Ludovica Ciuffreda; Donatella Del Bufalo; Marianna Desideri; Cristina Di Sanza; Antonella Stoppacciaro; Maria Rosaria Ricciardi; Sabina Chiaretti; Simona Tavolaro; Barbara Benassi; Alfonso Bellacosa; Robin Foà; Agostino Tafuri; Francesco Cognetti; Andrea Anichini; Gabriella Zupi; Michele Milella
Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations.
Neoplasia (New York, N.Y.) 2009;11(8):720-31.
2008: Chiara Gabellini; Laura Castellini; Daniela Trisciuoglio; Michael Kracht; Gabriella Zupi; Donatella Del Bufalo
Involvement of nuclear factor-kappa B in bcl-xL-induced interleukin 8 expression in glioblastoma.
Journal of neurochemistry 2008;107(3):871-82.
2008: Daniela Trisciuoglio; Badarch Uranchimeg; John H Cardellina; Tamara L Meragelman; Shigeki Matsunaga; Nobuhiru Fusetani; Donatella Del Bufalo; Robert H Shoemaker; Giovanni Melillo
Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide.
Journal of the National Cancer Institute 2008;100(17):1233-46.
2007: Simona Giorgini; Daniela Trisciuoglio; Chiara Gabellini; Marianna Desideri; Laura Castellini; Cristina Colarossi; Uwe Zangemeister-Wittke; Gabriella Zupi; Donatella Del Bufalo
Modulation of bcl-xL in tumor cells regulates angiogenesis through CXCL8 expression.
Molecular cancer research : MCR 2007;5(8):761-71.
2006: Chiara Gabellini; Donatella Del Bufalo; Gabriella Zupi
Involvement of RB gene family in tumor angiogenesis.
Oncogene 2006;25(38):5326-32.
2006: Donatella Del Bufalo; Ludovica Ciuffreda; Daniela Trisciuoglio; Marianna Desideri; Francesco Cognetti; Gabriella Zupi; Michele Milella
Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus.
Cancer research 2006;66(11):5549-54.
2005: Daniela Trisciuoglio; Marianna Desideri; Ludovica Ciuffreda; Marcella Mottolese; Dragana Vukasovic; Angelo Vacca; Mario Del Rosso; Lucia Marcocci; Gabriella Zupi; Donatella Del Bufalo
Bcl-2 overexpression in melanoma cells increases tumor progression-associated properties and in vivo tumor growth.
Journal of cellular physiology 2005;205(3):414-21.
2005: Donatella Del Bufalo; A Rizzo; Daniela Trisciuoglio; Giorgia Cardinali; Maria Rosaria Torrisi; Uwe Zangemeister-Wittke; Gabriella Zupi; Annamaria Biroccio
Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function.
Cell death and differentiation 2005;12(11):1429-38.
2005: Daniela Trisciuoglio; Angela Iervolino; Gabriella Zupi; Donatella Del Bufalo
Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells.
Molecular biology of the cell 2005;16(9):4153-62.
2005: Michelandrea De Cesare; Paola Perego; Sabina C Righetti; Graziella Pratesi; Nives Carenini; Licia Rivoltini; Gabriella Zupi; Donatella Del Bufalo; Andrea Balsari; Franco Zunino
Enhanced antitumour efficacy of gimatecan in combination with Bcl-2 antisense oligonucleotide in human melanoma xenografts.
European journal of cancer (Oxford, England : 1990) 2005;41(8):1213-22.
2004: Michele Milella; Daniela Trisciuoglio; Tiziana Bruno; Ludovica Ciuffreda; Marcella Mottolese; Anna Maria Cianciulli; Francesco Cognetti; Uwe Zangemeister-Wittke; Donatella Del Bufalo; Gabriella Zupi
Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2/Bcl-XL bispecific antisense oligonucleotides in HER-2 gene--amplified breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7747-56.
2004: Donatella Del Bufalo; Daniela Trisciuoglio; Marco Scarsella; Giulia d'Amati; Antonio Candiloro; Angela Iervolino; Carlo Leonetti; Gabriella Zupi
Lonidamine causes inhibition of angiogenesis-related endothelial cell functions.
Neoplasia (New York, N.Y.) 2004;6(5):513-22.
2004: Daniela Trisciuoglio; Angela Iervolino; Antonio Candiloro; Gabriella Fibbi; Maurizio Fanciulli; Uwe Zangemeister-Wittke; Gabriella Zupi; Donatella Del Bufalo
bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity.
The Journal of biological chemistry 2004;279(8):6737-45.
2003: Donatella Del Bufalo; Daniela Trisciuoglio; Marco Scarsella; Uwe Zangemeister-Wittke; Gabriella Zupi
Treatment of melanoma cells with a bcl-2/bcl-xL antisense oligonucleotide induces antiangiogenic activity.
Oncogene 2003;22(52):8441-7.
2003: Annamaria Biroccio; Chiara Gabellini; Sarah Amodei; Barbara Benassi; Donatella Del Bufalo; Raffaella Elli; Anna Antonelli; Maurizio D'Incalci; Gabriella Zupi
Telomere dysfunction increases cisplatin and ecteinascidin-743 sensitivity of melanoma cells.
Molecular pharmacology 2003;63(3):632-8.
2002: Donatella Del Bufalo; Annamaria Biroccio; Daniela Trisciuoglio; Tiziana Bruno; Aristide Floridi; A Aquino; Gabriella Zupi
Bcl-2 has differing effects on the sensitivity of breast cancer cells depending on the antineoplastic drug used.
European journal of cancer (Oxford, England : 1990) 2002;38(18):2455-62.
2002: Angela Iervolino; Daniela Trisciuoglio; Dragana Vukasovic; Antonio Candiloro; Annamaria Biroccio; Gabriella Zupi; Donatella Del Bufalo
Bcl-2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF-1-mediated transcriptional activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(11):1453-5.
2002: Donatella Del Bufalo; Valeriana Di Castro; Annamaria Biroccio; Debora Salani; Laura Rosanò; Francesca Spinella; Anna Bagnato
Endothelin-1 acts as a survival factor in ovarian carcinoma cells.
Clinical science (London, England : 1979) 2002;103 Suppl 48():302S-305S.
2002: Annamaria Biroccio; Sarah Amodei; Barbara Benassi; Marco Scarsella; Anna Maria Cianciulli; Marcella Mottolese; Donatella Del Bufalo; Carlo Leonetti; Gabriella Zupi
Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones.
Oncogene 2002;21(19):3011-9.
2002: Fortunato Ciardiello; Rosa Caputo; Giorgia Borriello; Donatella Del Bufalo; Annamaria Biroccio; Gabriella Zupi; Angelo Raffaele Bianco; Giampaolo Tortora
ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells.
International journal of cancer. Journal international du cancer 2002;98(3):463-9.
2002: Donatella Del Bufalo; Valeriana Di Castro; Annamaria Biroccio; Marco Varmi; Debora Salani; Laura Rosanò; Daniela Trisciuoglio; Francesca Spinella; Anna Bagnato
Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation.
Molecular pharmacology 2002;61(3):524-32.
2001: A Ricca; Annamaria Biroccio; Daniela Trisciuoglio; Marco Cippitelli; Gabriella Zupi; Donatella Del Bufalo
relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells.
British journal of cancer 2001;85(12):1914-21.
2001: Donatella Del Bufalo; Daniela Trisciuoglio; Annamaria Biroccio; L Marcocci; Simonetta Buglioni; Antonio Candiloro; Marco Scarsella; Carlo Leonetti; Gabriella Zupi
Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity.
Journal of cellular biochemistry 2001;83(3):473-83.
2001: Annamaria Biroccio; Barbara Benassi; Sarah Amodei; Chiara Gabellini; Donatella Del Bufalo; Gabriella Zupi
c-Myc down-regulation increases susceptibility to cisplatin through reactive oxygen species-mediated apoptosis in M14 human melanoma cells.
Molecular pharmacology 2001;60(1):174-82.
2000: A Ricca; Annamaria Biroccio; Donatella Del Bufalo; A R Mackay; Angela Santoni; Marco Cippitelli
bcl-2 over-expression enhances NF-kappaB activity and induces mmp-9 transcription in human MCF7(ADR) breast-cancer cells.
International journal of cancer. Journal international du cancer 2000;86(2):188-96.
2000: Annamaria Biroccio; Antonio Candiloro; Marcella Mottolese; O Sapora; A Albini; Gabriella Zupi; Donatella Del Bufalo
Bcl-2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression and in vivo angiogenesis in a breast carcinoma line.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(5):652-60.
1999: Carlo Leonetti; Annamaria Biroccio; Antonio Candiloro; Gennaro Citro; C Fornari; Marcella Mottolese; Donatella Del Bufalo; Gabriella Zupi
Increase of cisplatin sensitivity by c-myc antisense oligodeoxynucleotides in a human metastatic melanoma inherently resistant to cisplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2588-95.
1999: Annamaria Biroccio; Donatella Del Bufalo; Maurizio Fanciulli; Tiziana Bruno; Gabriella Zupi; Aristide Floridi
bcl-2 inhibits mitochondrial metabolism and lonidamine-induced apoptosis in adriamycin-resistant MCF7 cells.
International journal of cancer. Journal international du cancer 1999;82(1):125-30.
1998: Donatella Del Bufalo; Carlo Leonetti; Barbara Bucci; C Amedeo; R Falcioni; Annamaria Biroccio; Gabriella Zupi
N-methylformamide induces changes on adhesive properties and lung-colonizing potential of M14 melanoma cells.
British journal of cancer 1998;77(2):210-5.
1997: Donatella Del Bufalo; Annamaria Biroccio; Carlo Leonetti; Gabriella Zupi
Bcl-2 overexpression enhances the metastatic potential of a human breast cancer line.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(12):947-53.
1996: Donatella Del Bufalo; Annamaria Biroccio; Silvia Soddu; N Laudonio; Carmen D'Angelo; A Sacchi; Gabriella Zupi
Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.
The Journal of clinical investigation 1996;98(5):1165-73.
1996: Donatella Del Bufalo; C Cucco; Carlo Leonetti; Gennaro Citro; Igea D'Agnano; M Benassi; T Geiser; G Zon; Bruno Calabretta; Gabriella Zupi
Effect of cisplatin and c-myb antisense phosphorothioate oligodeoxynucleotides combination on a human colon carcinoma cell line in vitro and in vivo.
British journal of cancer 1996;74(3):387-93.
1995: Gabriella Zupi; Agnese Molinari; Igea D'Agnano; Stefania Meschini; Donatella Del Bufalo; Paola Matarrese; A Candiloro; Annarica Calcabrini; Gennaro Citro; Giuseppe Arancia
Adriamycin resistance modulation induced by lonidamine in human breast cancer cells.
Anticancer research 1995;15(6B):2469-77.
1994: Donatella Del Bufalo; Barbara Bucci; Igea D'Agnano; Gabriella Zupi
N-methylformamide as a potential therapeutic approach in colon cancer.
Diseases of the colon and rectum 1994;37(2 Suppl):S133-7.
1991: Donatella Del Bufalo; M Marangolo; Gabriella Zupi
Therapeutic potential of differentiating agents in colon cancer treatment.
Journal of surgical oncology. Supplement 1991;2():14-5.
1990: N Laudonio; L Marcocci; Giuseppe Arancia; Annarica Calcabrini; Donatella Del Bufalo; C Greco; Gabriella Zupi; Irene Mavelli; Jens Z Pedersen; A Bozzi
Enhancement of hyperthermic damage on M14 melanoma cells by liposome pretreatment.
Cancer research 1990;50(16):5119-26.
1990: Donatella Del Bufalo; C Cucco; Carlo Leonetti
[The use of continuous cell cultures for the study of tumor heterogeneity and drug sensitivity].
Medicina (Florence, Italy) 1990;10(3):298-302.
1990: C Greco; Donatella Del Bufalo; D Giannarelli; M Marangolo; M P Fuggetta; E Bonmassar; Gabriella Zupi
N-methylformamide affects spontaneous metastases of 3LL lines and increases natural killer activity of tumor-bearing mice.
Clinical & experimental metastasis 1990;8(2):153-63.
1989: Carlo Leonetti; Igea D'Agnano; Donatella Del Bufalo; Carmine Maria Carapella; Gabriella Zupi
Human glioma lines as experimental model for biological and chemosensitivity studies.
Journal of neurosurgical sciences 1989;33(1):39-42.