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Giuseppe Del Giudice

Research Profile

Living Beings

Chemicals & Drugs

Disorders

Helicobacter Infections

Procedures

Physiology

Immunity, Mucosal

Anatomy

CD4-Positive T-Lymphocytes

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Publications

TOP 3
Francesca Buricchi; Barbara Capecchi; Flora Castellino; Giuseppe Del Giudice; Elena Fragapane; Grazia Galli; Carmine Malzone; Uwe Nicolay; Monia Bardelli; Oretta Finco
Impact of preexisting memory to seasonal A/H1N1 influenza virus on the immune response following vaccination against avian A/H5N1 virus.
Elisa Faenzi; Oretta Finco; Syed Sohail Ahmed; Monia Bardelli; Riccardo Belli; Erica Borgogni; Francesca Buricchi; Pier Leopoldo Capecchi; Flora Castellino; Giuseppe Del Giudice; Maria Lattanzi; Fabio Montanaro; EMANUELE MONTOMOLI; Franco Laghi Pasini; Simona Piccirella; Rino Rappuoli; Fabiana Spensieri; Gianfranco Volpini; Luisanna Zedda; Grazia Galli
One dose of an MF59-adjuvanted pandemic A/H1N1 vaccine recruits pre-existing immune memory and induces the rapid rise of neutralizing antibodies.
Benedetta Romi; Elisabetta Soldaini; Laura Pancotto; Flora Castellino; Giuseppe Del Giudice; Francesca Schiavetti
Helicobacter pylori induces activation of human peripheral γδ+ T lymphocytes.

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All Publications

2013: Francesca Buricchi; Barbara Capecchi; Flora Castellino; Giuseppe Del Giudice; Elena Fragapane; Grazia Galli; Carmine Malzone; Uwe Nicolay; Monia Bardelli; Oretta Finco
Impact of preexisting memory to seasonal A/H1N1 influenza virus on the immune response following vaccination against avian A/H5N1 virus.
European journal of immunology 2013;43(3):641-8.
2012: Elisa Faenzi; Oretta Finco; Syed Sohail Ahmed; Monia Bardelli; Riccardo Belli; Erica Borgogni; Francesca Buricchi; Pier Leopoldo Capecchi; Flora Castellino; Giuseppe Del Giudice; Maria Lattanzi; Fabio Montanaro; EMANUELE MONTOMOLI; Franco Laghi Pasini; Simona Piccirella; Rino Rappuoli; Fabiana Spensieri; Gianfranco Volpini; Luisanna Zedda; Grazia Galli
One dose of an MF59-adjuvanted pandemic A/H1N1 vaccine recruits pre-existing immune memory and induces the rapid rise of neutralizing antibodies.
Vaccine 2012;30(27):4086-94.
2011: Benedetta Romi; Elisabetta Soldaini; Laura Pancotto; Flora Castellino; Giuseppe Del Giudice; Francesca Schiavetti
Helicobacter pylori induces activation of human peripheral γδ+ T lymphocytes.
PloS one 2011;6(4):e19324.
2010: Filippo Ansaldi; Marta Zancolli; Paolo Durando; EMANUELE MONTOMOLI; Laura Sticchi; Giuseppe Del Giudice; Giancarlo Icardi
Antibody response against heterogeneous circulating influenza virus strains elicited by MF59- and non-adjuvanted vaccines during seasons with good or partial matching between vaccine strain and clinical isolates.
Vaccine 2010;28(25):4123-9.
2009: Giuseppe Del Giudice; Peter Malfertheiner; Rino Rappuoli
Development of vaccines against Helicobacter pylori.
Expert review of vaccines 2009;8(8):1037-49.
2009: Claudia Gianfaldoni; Silvia Maccari; Laura Pancotto; Giacomo Rossi; Markus Hilleringmann; Werner Pansegrau; Antonia Sinisi; Monica Moschioni; Vega Masignani; Rino Rappuoli; Giuseppe Del Giudice; Paolo Ruggiero
Sortase A confers protection against Streptococcus pneumoniae in mice.
Infection and immunity 2009;77(7):2957-61.
2009: Grazia Galli; Duccio Medini; Erica Borgogni; Luisanna Zedda; Monia Bardelli; Carmine Malzone; Sandra Nuti; Simona Tavarini; Chiara Sammicheli; Anne K Hilbert; V F H Brauer; Angelika Banzhoff; Rino Rappuoli; Giuseppe Del Giudice; Flora Castellino
Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3877-82.
2008: Peter Malfertheiner; Viola Schultze; Bernd Rosenkranz; Stefan H E Kaufmann; Timo Ulrichs; Deborah Novicki; Francesco Norelli; Mario Contorni; Samuele Peppoloni; Duccio Berti; Daniela Tornese; Jitendra Ganju; Emanuela Palla; Rino Rappuoli; Bruce F Scharschmidt; Giuseppe Del Giudice
Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: a phase I study.
Gastroenterology 2008;135(3):787-95.
2008: Paolo Durando; Daniela Fenoglio; Antonio Boschini; Filippo Ansaldi; Giancarlo Icardi; Laura Sticchi; A Renzoni; P Fabbri; Alessandra Ferrera; A Parodi; Bianca Bruzzone; Giovanni Gabutti; Audino Podda; Giuseppe Del Giudice; Elena Fragapane; Francesco Indiveri; Pietro Crovari; Roberto Gasparini
Safety and immunogenicity of two influenza virus subunit vaccines, with or without MF59 adjuvant, administered to human immunodeficiency virus type 1-seropositive and -seronegative adults.
Clinical and vaccine immunology : CVI 2008;15(2):253-9.
2008: Andreas Wack; Barbara C Baudner; Anne K Hilbert; Ilaria Manini; Sandra Nuti; Simona Tavarini; Hanno Scheffczik; Mildred Ugozzoli; Manmohan Singh; Jina Kazzaz; EMANUELE MONTOMOLI; Giuseppe Del Giudice; Rino Rappuoli; Derek T O'Hagan
Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice.
Vaccine 2008;26(4):552-61.
2007: Michael Vajdy; Barbara C Baudner; Giuseppe Del Giudice; Derek O'Hagan
A vaccination strategy to enhance mucosal and systemic antibody and T cell responses against influenza.
Clinical immunology (Orlando, Fla.) 2007;123(2):166-75.
2007: Paolo Ruggiero; Giacomo Rossi; Francesco Tombola; Laura Pancotto; Laura Lauretti; Giuseppe Del Giudice; Mario Zoratti
Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model.
World journal of gastroenterology : WJG 2007;13(3):349-54.
2006: Giuseppe Del Giudice; Elena Fragapane; Roberto Bugarini; Maninder Hora; Thomas Henriksson; Emanuela Palla; Derek O'Hagan; John Donnelly; Rino Rappuoli; Audino Podda
Vaccines with the MF59 adjuvant do not stimulate antibody responses against squalene.
Clinical and vaccine immunology : CVI 2006;13(9):1010-3.
2006: Paolo Ruggiero; Francesco Tombola; Giacomo Rossi; Laura Pancotto; Laura Lauretti; Giuseppe Del Giudice; Mario Zoratti
Polyphenols reduce gastritis induced by Helicobacter pylori infection or VacA toxin administration in mice.
Antimicrobial agents and chemotherapy 2006;50(7):2550-2.
2006: Iain Stephenson; Maria C Zambon; Anna Rudin; Anthony Colegate; Audino Podda; Roberto Bugarini; Giuseppe Del Giudice; Ada Minutello; Susan Bonnington; Jan Holmgren; Kingston H G Mills; Karl G Nicholson
Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers.
Journal of virology 2006;80(10):4962-70.
2006: Giuseppe Del Giudice; Anne Katrin Hilbert; Roberto Bugarini; Ada Minutello; Olga Popova; daniela toneatto; Ines Schoendorf; Astrid Borkowski; Rino Rappuoli; Audino Podda
An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine.
Vaccine 2006;24(16):3063-5.
2005: Barbara C Baudner; Jan Verhoef; Marzia M Giuliani; Samuele Peppoloni; Rino Rappuoli; Giuseppe Del Giudice; Hans E Junginger
Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform.
Journal of drug targeting 2005;13(8-9):489-98.
2005: Karin Baraldo; Elena Mori; Antonella Bartoloni; Francesco Norelli; Guido Grandi; Rino Rappuoli; Oretta Finco; Giuseppe Del Giudice
Combined conjugate vaccines: enhanced immunogenicity with the N19 polyepitope as a carrier protein.
Infection and immunity 2005;73(9):5835-41.
2005: Elisabetta Blasi; Anna Mucci; Rachele Neglia; Francesco Pezzini; Bruna Colombari; Danuta Radzioch; Andrea Cossarizza; Enrico Lugli; Gianfranco Volpini; Giuseppe Del Giudice; Samuele Peppoloni
Biological importance of the two Toll-like receptors, TLR2 and TLR4, in macrophage response to infection with Candida albicans.
FEMS immunology and medical microbiology 2005;44(1):69-79.
2005: Marina de Bernard; Andrea Cappon; Laura Pancotto; Paolo Ruggiero; Juan Rivera; Giuseppe Del Giudice; Cesare Montecucco
The Helicobacter pylori VacA cytotoxin activates RBL-2H3 cells by inducing cytosolic calcium oscillations.
Cellular microbiology 2005;7(2):191-8.
2004: Karin Baraldo; Elena Mori; Antonella Bartoloni; Roberto Petracca; Aldo Giannozzi; Francesco Norelli; Rino Rappuoli; Guido Grandi; Giuseppe Del Giudice
N19 polyepitope as a carrier for enhanced immunogenicity and protective efficacy of meningococcal conjugate vaccines.
Infection and immunity 2004;72(8):4884-7.
2004: Giacomo Rossi; Paolo Ruggiero; Samuele Peppoloni; Laura Pancotto; Damiano Fortuna; Laura Lauretti; Gianfranco Volpini; Silvia Mancianti; Michele Corazza; Ennio Taccini; Francesco Di Pisa; Rino Rappuoli; Giuseppe Del Giudice
Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy.
Infection and immunity 2004;72(6):3252-9.
2004: Marina de Bernard; Andrea Cappon; Giuseppe Del Giudice; Rino Rappuoli; Cesare Montecucco
The multiple cellular activities of the VacA cytotoxin of Helicobacter pylori.
International journal of medical microbiology : IJMM 2004;293(7-8):589-97.
2004: Giacomo Rossi; Stefano Romagnoli; Laura Lauretti; Laura Pancotto; Ennio Taccini; Rino Rappuoli; Giuseppe Del Giudice; Paolo Ruggiero
Helicobacter pylori infection negatively influences pregnancy outcome in a mouse model.
Helicobacter 2004;9(2):152-7.
2004: Barbara C Baudner; Maurizio Morandi; Marzia M Giuliani; Jan Verhoef; Hans E Junginger; paolo costantino; Rino Rappuoli; Giuseppe Del Giudice
Modulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery system.
The Journal of infectious diseases 2004;189(5):828-32.
2004: J Daniel Dubreuil; Paolo Ruggiero; Rino Rappuoli; Giuseppe Del Giudice
Effect of heparin binding on Helicobacter pylori resistance to serum.
Journal of medical microbiology 2004;53(Pt 1):9-12.
2003: Michael Vajdy; Manmohan Singh; Mildred Ugozzoli; Maylene Briones; Elawati Soenawan; Lina Cuadra; Jina Kazzaz; Paolo Ruggiero; Samuele Peppoloni; Francesco Norelli; Giuseppe Del Giudice; Derek O'Hagan
Enhanced mucosal and systemic immune responses to Helicobacter pylori antigens through mucosal priming followed by systemic boosting immunizations.
Immunology 2003;110(1):86-94.
2003: Paolo Ruggiero; Samuele Peppoloni; Rino Rappuoli; Giuseppe Del Giudice
The quest for a vaccine against Helicobacter pylori: how to move from mouse to man?
Microbes and infection / Institut Pasteur 2003;5(8):749-56.
2003: Giuseppe Del Giudice
Vaccination strategies. An overview.
Vaccine 2003;21 Suppl 2():S83-8.
2003: Francesco Tombola; Silvia Campello; Laura De Luca; Paolo Ruggiero; Giuseppe Del Giudice; Emanuele Papini; Mario Zoratti
Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori.
FEBS letters 2003;543(1-3):184-9.
2003: Samuele Peppoloni; Paolo Ruggiero; Mario Contorni; Maurizio Morandi; Mariagrazia Pizza; Rino Rappuoli; Audino Podda; Giuseppe Del Giudice
Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines.
Expert review of vaccines 2003;2(2):285-93.
2003: Audino Podda; Giuseppe Del Giudice
MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile.
Expert review of vaccines 2003;2(2):197-203.
2003: Hiroaki Nishioka; Ilenia Baesso; Gianpietro Semenzato; Livio Trentin; Rino Rappuoli; Giuseppe Del Giudice; Cesare Montecucco
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils.
European journal of immunology 2003;33(4):840-9.
2002: Mildred Ugozzoli; Massimo Mariani; Giuseppe Del Giudice; Elawati Soenawan; Derek T O'Hagan
Combinations of protein polysaccharide conjugate vaccines for intranasal immunization.
The Journal of infectious diseases 2002;186(9):1358-61.
2002: Samuele Peppoloni; Silvia Mancianti; Gianfranco Volpini; Sandra Nuti; Paolo Ruggiero; Rino Rappuoli; Elisabetta Blasi; Giuseppe Del Giudice
Antibody-dependent macrophage-mediated activity against Helicobacter pylori in the absence of complement.
European journal of immunology 2002;32(10):2721-5.
2002: Barbara C Baudner; O Balland; Marzia M Giuliani; Paul von Hoegen; Rino Rappuoli; D Betbeder; Giuseppe Del Giudice
Enhancement of protective efficacy following intranasal immunization with vaccine plus a nontoxic LTK63 mutant delivered with nanoparticles.
Infection and immunity 2002;70(9):4785-90.
2002: Pasqualina Montemurro; Hiroaki Nishioka; William G Dundon; Marina de Bernard; Giuseppe Del Giudice; Rino Rappuoli; Cesare Montecucco
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells.
European journal of immunology 2002;32(3):671-6.
2001: Fabiana Falugi; Roberto Petracca; Massimo Mariani; E Luzzi; Silvia Mancianti; V Carinci; M L Melli; Oretta Finco; Andreas Wack; A Di Tommaso; Maria Teresa De Magistris; paolo costantino; Giuseppe Del Giudice; Sergio Abrignani; Rino Rappuoli; Guido Grandi
Rationally designed strings of promiscuous CD4(+) T cell epitopes provide help to Haemophilus influenzae type b oligosaccharide: a model for new conjugate vaccines.
European journal of immunology 2001;31(12):3816-24.
2001: Laura Morbiato; Francesco Tombola; Silvia Campello; Giuseppe Del Giudice; Rino Rappuoli; Mario Zoratti; Emanuele Papini
Vacuolation induced by VacA toxin of Helicobacter pylori requires the intracellular accumulation of membrane permeant bases, Cl(-) and water.
FEBS letters 2001;508(3):479-83.
2001: Giuseppe Del Giudice; Audino Podda; Rino Rappuoli
What are the limits of adjuvanticity?
Vaccine 2001;20 Suppl 1():S38-41.
2001: Francesco Tombola; Laura Morbiato; Giuseppe Del Giudice; Rino Rappuoli; Mario Zoratti; Emanuele Papini
The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia.
The Journal of clinical investigation 2001;108(6):929-37.
2001: Pasqualina Montemurro; Giovanna Barbuti; William G Dundon; Giuseppe Del Giudice; Rino Rappuoli; Mario Colucci; Pietro De Rinaldis; Cesare Montecucco; Nicola Semeraro; Emanuele Papini
Helicobacter pylori neutrophil-activating protein stimulates tissue factor and plasminogen activator inhibitor-2 production by human blood mononuclear cells.
The Journal of infectious diseases 2001;183(7):1055-62.
2001: Mariagrazia Pizza; Marzia M Giuliani; Maria Rita Fontana; Elisabetta Monaci; G Douce; Gordon Dougan; Kingston H G Mills; Rino Rappuoli; Giuseppe Del Giudice
Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.
Vaccine 2001;19(17-19):2534-41.
2001: Giuseppe Del Giudice; Antonello Covacci; John L Telford; C Montecucco; Rino Rappuoli
The design of vaccines against Helicobacter pylori and their development.
Annual review of immunology 2001;19():523-63.
2000: Francesco Tombola; Giuseppe Del Giudice; Emanuele Papini; Mario Zoratti
Blockers of VacA provide insights into the structure of the pore.
Biophysical journal 2000;79(2):863-73.
2000: Giacomo Rossi; Damiano Fortuna; Laura Pancotto; G Renzoni; Ennio Taccini; P Ghiara; Rino Rappuoli; Giuseppe Del Giudice
Immunohistochemical study of lymphocyte populations infiltrating the gastric mucosa of beagle dogs experimentally infected with Helicobacter pylori.
Infection and immunity 2000;68(8):4769-72.
2000: B Satin; Giuseppe Del Giudice; V Della Bianca; S Dusi; C Laudanna; Fiorella Tonello; D Kelleher; Rino Rappuoli; Cesare Montecucco; F Rossi
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor.
The Journal of experimental medicine 2000;191(9):1467-76.
1999: Francesco Tombola; F Oregna; S Brutsche; Ildikò Szabò; Giuseppe Del Giudice; R Rappuoli; Cesare Montecucco; Emanuele Papini; Mario Zoratti
Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori.
FEBS letters 1999;460(2):221-5.
1999: Fiorella Tonello; William G Dundon; B Satin; M Molinari; Giuseppe Tognon; G Grandi; Giuseppe Del Giudice; Rino Rappuoli; Cesare Montecucco
The Helicobacter pylori neutrophil-activating protein is an iron-binding protein with dodecameric structure.
Molecular microbiology 1999;34(2):238-46.
1999: Giacomo Rossi; M Rossi; Claudio Vitali; Damiano Fortuna; D Burroni; Laura Pancotto; S Capecchi; S Sozzi; G Renzoni; G Braca; Giuseppe Del Giudice; Rino Rappuoli; P Ghiara; Ennio Taccini
A conventional beagle dog model for acute and chronic infection with Helicobacter pylori.
Infection and immunity 1999;67(6):3112-20.
1998: Giuseppe Del Giudice; P Ghiara; Rino Rappuoli
Experimental model of Helicobacter pylori infection.
Italian journal of gastroenterology and hepatology 1998;30 Suppl 3():S261-3.
1998: Marzia M Giuliani; Giuseppe Del Giudice; V Giannelli; Gordon Dougan; G Douce; Rino Rappuoli; Mariagrazia Pizza
Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity.
The Journal of experimental medicine 1998;187(7):1123-32.
1998: Renata Grifantini; Oretta Finco; Erika Bartolini; Monia Draghi; Giuseppe Del Giudice; C Kocken; A Thomas; Sergio Abrignani; Guido Grandi
Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid.
European journal of immunology 1998;28(4):1225-32.
1997: P Ghiara; M Rossi; M Marchetti; A Di Tommaso; Carla Vindigni; F Ciampolini; Antonello Covacci; John L Telford; Maria Teresa De Magistris; Mariagrazia Pizza; Rino Rappuoli; Giuseppe Del Giudice
Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection.
Infection and immunity 1997;65(12):4996-5002.