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Giuseppe Del Giudice
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35
Rappuoli, Rino
11
Ruggiero, Paolo
8
Pancotto, Laura
8
Peppoloni, Samuele
8
Montecucco, Cesare
7
Podda, Audino
7
Tombola, Francesco
7
Rossi, Giacomo
7
Zoratti, Mario
6
Papini, Emanuele
5
Giuliani, Marzia
5
Baudner, Barbara
4
Ghiara, P
4
Grandi, Guido
4
Lauretti, Laura
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All Publications
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2009: Del Giudice Giuseppe; Malfertheiner Peter; Rappuoli Rino
Development of vaccines against Helicobacter pylori.
Expert review of vaccines 2009;8(8):1037-49.
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2009: Gianfaldoni Claudia; Maccari Silvia; Pancotto Laura; Rossi Giacomo; Hilleringmann Markus; Pansegrau Werner; Sinisi Antonia; Moschioni Monica; Masignani Vega; Rappuoli Rino; Del Giudice Giuseppe; Ruggiero Paolo
Sortase A confers protection against Streptococcus pneumoniae in mice.
Infection and immunity 2009;77(7):2957-61.
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2009: Galli Grazia; Medini Duccio; Borgogni Erica; Zedda Luisanna; Bardelli Monia; Malzone Carmine; Nuti Sandra; Tavarini Simona; Sammicheli Chiara; Hilbert Anne K; Brauer Volker; Banzhoff Angelika; Rappuoli Rino; Del Giudice Giuseppe; Castellino Flora
Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3877-82.
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2008: Malfertheiner Peter; Schultze Viola; Rosenkranz Bernd; Kaufmann Stefan H E; Ulrichs Timo; Novicki Deborah; Norelli Francesco; Contorni Mario; Peppoloni Samuele; Berti Duccio; Tornese Daniela; Ganju Jitendra; Palla Emanuela; Rappuoli Rino; Scharschmidt Bruce F; Del Giudice Giuseppe
Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: a phase I study.
Gastroenterology 2008;135(3):787-95.
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2008: Durando P; Fenoglio D; Boschini A; Ansaldi F; Icardi G; Sticchi L; Renzoni A; Fabbri P; Ferrera A; Parodi A; Bruzzone B; Gabutti G; Podda A; Del Giudice G; Fragapane E; Indiveri F; Crovari P; Gasparini R
Safety and immunogenicity of two influenza virus subunit vaccines, with or without MF59 adjuvant, administered to human immunodeficiency virus type 1-seropositive and -seronegative adults.
Clinical and vaccine immunology : CVI 2008;15(2):253-9.
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2008: Wack Andreas; Baudner Barbara C; Hilbert Anne K; Manini Ilaria; Nuti Sandra; Tavarini Simona; Scheffczik Hanno; Ugozzoli Mildred; Singh Manmohan; Kazzaz Jina; Montomoli Emanuele; Del Giudice Giuseppe; Rappuoli Rino; O'Hagan Derek T
Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice.
Vaccine 2008;26(4):552-61.
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2007: Vajdy Michael; Baudner Barbara; Del Giudice Giuseppe; O'Hagan Derek
A vaccination strategy to enhance mucosal and systemic antibody and T cell responses against influenza.
Clinical immunology (Orlando, Fla.) 2007;123(2):166-75.
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2007: Ruggiero Paolo; Rossi Giacomo; Tombola Francesco; Pancotto Laura; Lauretti Laura; Del Giudice Giuseppe; Zoratti Mario
Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model.
World journal of gastroenterology : WJG 2007;13(3):349-54.
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2006: Del Giudice Giuseppe; Fragapane Elena; Bugarini Roberto; Hora Maninder; Henriksson Thomas; Palla Emanuela; O'hagan Derek; Donnelly John; Rappuoli Rino; Podda Audino
Vaccines with the MF59 adjuvant do not stimulate antibody responses against squalene.
Clinical and vaccine immunology : CVI 2006;13(9):1010-3.
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2006: Ruggiero P; Tombola F; Rossi G; Pancotto L; Lauretti L; Del Giudice G; Zoratti M
Polyphenols reduce gastritis induced by Helicobacter pylori infection or VacA toxin administration in mice.
Antimicrobial agents and chemotherapy 2006;50(7):2550-2.
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2006: Stephenson Iain; Zambon Maria C; Rudin Anna; Colegate Anthony; Podda Audino; Bugarini Roberto; Del Giudice Giusseppe; Minutello Ada; Bonnington Susan; Holmgren Jan; Mills Kingston H G; Nicholson Karl G
Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers.
Journal of virology 2006;80(10):4962-70.
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2006: Del Giudice Giuseppe; Hilbert Anne Katrin; Bugarini Roberto; Minutello Ada; Popova Olga; Toneatto Daniela; Schoendorf Ines; Borkowski Astrid; Rappuoli Rino; Podda Audino
An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine.
Vaccine 2006;24(16):3063-5.
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2005: Baudner Barbara C; Verhoef J Coos; Giuliani Marzia M; Peppoloni Samuele; Rappuoli Rino; Del Giudice Giuseppe; Junginger Hans E
Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform.
Journal of drug targeting 2005;13(8-9):489-98.
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2005: Baraldo Karin; Mori Elena; Bartoloni Antonella; Norelli Francesco; Grandi Guido; Rappuoli Rino; Finco Oretta; Del Giudice Giuseppe
Combined conjugate vaccines: enhanced immunogenicity with the N19 polyepitope as a carrier protein.
Infection and immunity 2005;73(9):5835-41.
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2005: Blasi Elisabetta; Mucci Anna; Neglia Rachele; Pezzini Francesco; Colombari Bruna; Radzioch Danuta; Cossarizza Andrea; Lugli Enrico; Volpini Gianfranco; Del Giudice Giuseppe; Peppoloni Samuele
Biological importance of the two Toll-like receptors, TLR2 and TLR4, in macrophage response to infection with Candida albicans.
FEMS immunology and medical microbiology 2005;44(1):69-79.
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2005: de Bernard Marina; Cappon Andrea; Pancotto Laura; Ruggiero Paolo; Rivera Juan; Del Giudice Giuseppe; Montecucco Cesare
The Helicobacter pylori VacA cytotoxin activates RBL-2H3 cells by inducing cytosolic calcium oscillations.
Cellular microbiology 2005;7(2):191-8.
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2004: Baraldo Karin; Mori Elena; Bartoloni Antonella; Petracca Roberto; Giannozzi Aldo; Norelli Francesco; Rappuoli Rino; Grandi Guido; Del Giudice Giuseppe
N19 polyepitope as a carrier for enhanced immunogenicity and protective efficacy of meningococcal conjugate vaccines.
Infection and immunity 2004;72(8):4884-7.
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2004: Rossi Giacomo; Ruggiero Paolo; Peppoloni Samuele; Pancotto Laura; Fortuna Damiano; Lauretti Laura; Volpini Gianfranco; Mancianti Silvia; Corazza Michele; Taccini Ennio; Di Pisa Francesco; Rappuoli Rino; Del Giudice Giuseppe
Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy.
Infection and immunity 2004;72(6):3252-9.
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2004: de Bernard Marina; Cappon Andrea; Del Giudice Giuseppe; Rappuoli Rino; Montecucco Cesare
The multiple cellular activities of the VacA cytotoxin of Helicobacter pylori.
International journal of medical microbiology : IJMM 2004;293(7-8):589-97.
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2004: Rossi Giacomo; Romagnoli Stefano; Lauretti Laura; Pancotto Laura; Taccini Ennio; Rappuoli Rino; Del Giudice Giuseppe; Ruggiero Paolo
Helicobacter pylori infection negatively influences pregnancy outcome in a mouse model.
Helicobacter 2004;9(2):152-7.
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2004: Baudner Barbara C; Morandi Maurizio; Giuliani Marzia M; Verhoef J Coos; Junginger Hans E; Costantino Paolo; Rappuoli Rino; Del Giudice Giuseppe
Modulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery system.
The Journal of infectious diseases 2004;189(5):828-32.
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2004: Dubreuil J Daniel; Ruggiero Paolo; Rappuoli Rino; Del Giudice Giuseppe
Effect of heparin binding on Helicobacter pylori resistance to serum.
Journal of medical microbiology 2004;53(Pt 1):9-12.
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2003: Vajdy Michael; Singh Manmohan; Ugozzoli Mildred; Briones Maylene; Soenawan Elawati; Cuadra Lina; Kazzaz Jina; Ruggiero Paolo; Peppoloni Samuele; Norelli Francesco; del Giudice Giuseppe; O'Hagan Derek
Enhanced mucosal and systemic immune responses to Helicobacter pylori antigens through mucosal priming followed by systemic boosting immunizations.
Immunology 2003;110(1):86-94.
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2003: Ruggiero Paolo; Peppoloni Samuele; Rappuoli Rino; Del Giudice Giuseppe
The quest for a vaccine against Helicobacter pylori: how to move from mouse to man?
Microbes and infection / Institut Pasteur 2003;5(8):749-56.
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2003: Del Giudice Giuseppe
Vaccination strategies. An overview.
Vaccine 2003;21 Suppl 2():S83-8.
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2003: Tombola Francesco; Campello Silvia; De Luca Laura; Ruggiero Paolo; Del Giudice Giuseppe; Papini Emanuele; Zoratti Mario
Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori.
FEBS letters 2003;543(1-3):184-9.
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2003: Peppoloni Samuele; Ruggiero Paolo; Contorni Mario; Morandi Maurizio; Pizza Mariagrazia; Rappuoli Rino; Podda Audino; Del Giudice Giuseppe
Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines.
Expert review of vaccines 2003;2(2):285-93.
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2003: Podda Audino; Del Giudice Giuseppe
MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile.
Expert review of vaccines 2003;2(2):197-203.
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2003: Nishioka Hiroaki; Baesso Ilenia; Semenzato Gianpietro; Trentin Livio; Rappuoli Rino; Del Giudice Giuseppe; Montecucco Cesare
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils.
European journal of immunology 2003;33(4):840-9.
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2002: Ugozzoli Mildred; Mariani Massimo; Del Giudice Giuseppe; Soenawan Elawati; O'Hagan Derek T
Combinations of protein polysaccharide conjugate vaccines for intranasal immunization.
The Journal of infectious diseases 2002;186(9):1358-61.
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2002: Peppoloni Samuele; Mancianti Silvia; Volpini Gianfranco; Nuti Sandra; Ruggiero Paolo; Rappuoli Rino; Blasi Elisabetta; Del Giudice Giuseppe
Antibody-dependent macrophage-mediated activity against Helicobacter pylori in the absence of complement.
European journal of immunology 2002;32(10):2721-5.
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2002: Baudner B C; Balland O; Giuliani M M; Von Hoegen P; Rappuoli R; Betbeder D; Del Giudice G
Enhancement of protective efficacy following intranasal immunization with vaccine plus a nontoxic LTK63 mutant delivered with nanoparticles.
Infection and immunity 2002;70(9):4785-90.
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2002: Montemurro Pasqualina; Nishioka Hiroaki; Dundon William G; de Bernard Marina; Del Giudice Giuseppe; Rappuoli Rino; Montecucco Cesare
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells.
European journal of immunology 2002;32(3):671-6.
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2001: Falugi F; Petracca R; Mariani M; Luzzi E; Mancianti S; Carinci V; Melli M L; Finco O; Wack A; Di Tommaso A; De Magistris M T; Costantino P; Del Giudice G; Abrignani S; Rappuoli R; Grandi G
Rationally designed strings of promiscuous CD4(+) T cell epitopes provide help to Haemophilus influenzae type b oligosaccharide: a model for new conjugate vaccines.
European journal of immunology 2001;31(12):3816-24.
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2001: Morbiato L; Tombola F; Campello S; Del Giudice G; Rappuoli R; Zoratti M; Papini E
Vacuolation induced by VacA toxin of Helicobacter pylori requires the intracellular accumulation of membrane permeant bases, Cl(-) and water.
FEBS letters 2001;508(3):479-83.
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2001: Del Giudice G; Podda A; Rappuoli R
What are the limits of adjuvanticity?
Vaccine 2001;20 Suppl 1():S38-41.
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2001: Tombola F; Morbiato L; Del Giudice G; Rappuoli R; Zoratti M; Papini E
The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia.
The Journal of clinical investigation 2001;108(6):929-37.
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2001: Montemurro P; Barbuti G; Dundon W G; Del Giudice G; Rappuoli R; Colucci M; De Rinaldis P; Montecucco C; Semeraro N; Papini E
Helicobacter pylori neutrophil-activating protein stimulates tissue factor and plasminogen activator inhibitor-2 production by human blood mononuclear cells.
The Journal of infectious diseases 2001;183(7):1055-62.
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2001: Pizza M; Giuliani M M; Fontana M R; Monaci E; Douce G; Dougan G; Mills K H; Rappuoli R; Del Giudice G
Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.
Vaccine 2001;19(17-19):2534-41.
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2001: Del Giudice G; Covacci A; Telford J L; Montecucco C; Rappuoli R
The design of vaccines against Helicobacter pylori and their development.
Annual review of immunology 2001;19():523-63.
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2000: Tombola F; Del Giudice G; Papini E; Zoratti M
Blockers of VacA provide insights into the structure of the pore.
Biophysical journal 2000;79(2):863-73.
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2000: Rossi G; Fortuna D; Pancotto L; Renzoni G; Taccini E; Ghiara P; Rappuoli R; Del Giudice G
Immunohistochemical study of lymphocyte populations infiltrating the gastric mucosa of beagle dogs experimentally infected with Helicobacter pylori.
Infection and immunity 2000;68(8):4769-72.
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2000: Satin B; Del Giudice G; Della Bianca V; Dusi S; Laudanna C; Tonello F; Kelleher D; Rappuoli R; Montecucco C; Rossi F
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor.
The Journal of experimental medicine 2000;191(9):1467-76.
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1999: Tonello F; Dundon W G; Satin B; Molinari M; Tognon G; Grandi G; Del Giudice G; Rappuoli R; Montecucco C
The Helicobacter pylori neutrophil-activating protein is an iron-binding protein with dodecameric structure.
Molecular microbiology 1999;34(2):238-46.
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1999: Tombola F; Oregna F; Brutsche S; Szabò I; Del Giudice G; Rappuoli R; Montecucco C; Papini E; Zoratti M
Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori.
FEBS letters 1999;460(2):221-5.
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1999: Rossi G; Rossi M; Vitali C G; Fortuna D; Burroni D; Pancotto L; Capecchi S; Sozzi S; Renzoni G; Braca G; Del Giudice G; Rappuoli R; Ghiara P; Taccini E
A conventional beagle dog model for acute and chronic infection with Helicobacter pylori.
Infection and immunity 1999;67(6):3112-20.
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1998: Del Giudice G; Ghiara P; Rappuoli R
Experimental model of Helicobacter pylori infection.
Italian journal of gastroenterology and hepatology 1998;30 Suppl 3():S261-3.
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1998: Grifantini R; Finco O; Bartolini E; Draghi M; Del Giudice G; Kocken C; Thomas A; Abrignani S; Grandi G
Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid.
European journal of immunology 1998;28(4):1225-32.
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1998: Giuliani M M; Del Giudice G; Giannelli V; Dougan G; Douce G; Rappuoli R; Pizza M
Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity.
The Journal of experimental medicine 1998;187(7):1123-32.
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1997: Ghiara P; Rossi M; Marchetti M; Di Tommaso A; Vindigni C; Ciampolini F; Covacci A; Telford J L; De Magistris M T; Pizza M; Rappuoli R; Del Giudice G
Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection.
Infection and immunity 1997;65(12):4996-5002.
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