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Ian Alwayn

Research Profile

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Fatty Liver

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Jan P Deroose; Geert Kazemier; Pieter Zondervan; Jan N M Ijzermans; Herold J Metselaar; Ian P J Alwayn
Hepatic steatosis is not always a contraindication for cadaveric liver transplantation.
Leonienke F C Dols; Niels F M Kok; Turkan Terkivatan; Khe T C Tran; Ian P J Alwayn; Willem Weimar; Jan N M Ijzermans
Optimizing left-sided live kidney donation: hand-assisted retroperitoneoscopic as alternative to standard laparoscopic donor nephrectomy.
Robbert A M Strijbosch; Thelma L van den Hoonaard; Joanne F Olieman; Johanna C Escher; Ian P J Alwayn; Hanneke Meijers-Ijsselstijn
[Fish oil in prolonged parenteral nutrition in children--omega-3-fatty acids have a beneficial effect on the liver].

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All Publications

2011: Jan P Deroose; Geert Kazemier; Pieter Zondervan; Jan N M Ijzermans; Herold J Metselaar; Ian P J Alwayn
Hepatic steatosis is not always a contraindication for cadaveric liver transplantation.
HPB : the official journal of the International Hepato Pancreato Biliary Association 2011;13(6):417-25.
2010: Leonienke F C Dols; Niels F M Kok; Turkan Terkivatan; Khe T C Tran; Ian P J Alwayn; Willem Weimar; Jan N M Ijzermans
Optimizing left-sided live kidney donation: hand-assisted retroperitoneoscopic as alternative to standard laparoscopic donor nephrectomy.
Transplant international : official journal of the European Society for Organ Transplantation 2010;23(4):358-63.
2010: Robbert A M Strijbosch; Thelma L van den Hoonaard; Joanne F Olieman; Johanna C Escher; Ian P J Alwayn; Hanneke Meijers-Ijsselstijn
[Fish oil in prolonged parenteral nutrition in children--omega-3-fatty acids have a beneficial effect on the liver].
Nederlands tijdschrift voor geneeskunde 2010;154():A2003.
2010: Leonienke F C Dols; Niels F M Kok; Turkan Terkivatan; T C K Tran; Frank C H d'Ancona; Johan F Langenhuijsen; Ingrid R A M zur Borg; Ian P J Alwayn; Mark P Hendriks; Ine M Dooper; Willem Weimar; Jan N M Ijzermans
Hand-assisted retroperitoneoscopic versus standard laparoscopic donor nephrectomy: HARP-trial.
BMC surgery 2010;10():11.
2009: Meindert J Crop; Carla C Baan; Sander S Korevaar; Jan N M Ijzermans; Ian P J Alwayn; Willem Weimar; Martin J Hoogduijn
Donor-derived mesenchymal stem cells suppress alloreactivity of kidney transplant patients.
Transplantation 2009;87(6):896-906.
2009: Leonienke F C Dols; Niels F M Kok; Ian P J Alwayn; T C K Tran; Willem Weimar; Jan N M Ijzermans
Laparoscopic donor nephrectomy: a plea for the right-sided approach.
Transplantation 2009;87(5):745-50.
2008: Niels F M Kok; Leonienke F C Dols; M G Myriam Hunink; Ian P J Alwayn; Khe T C Tran; Willem Weimar; Jan N M Ijzermans
Complex vascular anatomy in live kidney donation: imaging and consequences for clinical outcome.
Transplantation 2008;85(12):1760-5.
2008: Niels F M Kok; J B C van der Wal; Ian P J Alwayn; Khe T C Tran; Jan N M Ijzermans
Laparoscopic kidney donation: The impact of adhesions.
Surgical endoscopy 2008;22(5):1321-5.
2008: Ian P J Alwayn; Jennifer E Verbesey; Sendia Kim; Roopali Roy; Danielle A Arsenault; Arin K Greene; Katherine Novak; Andrea Laforme; Sang Lee; Marsha A Moses; Mark Puder
A critical role for matrix metalloproteinases in liver regeneration.
The Journal of surgical research 2008;145(2):192-8.
2007: Ingrid R A M Mertens zur Borg; Niels F M Kok; Georgo Lambrou; David Jonsson; Ian P J Alwayn; Khe T C Tran; Willem Weimar; Jan N M Ijzermans; Diederik Gommers
Beneficial effects of a new fluid regime on kidney function of donor and recipient during laparoscopic v open donor nephrectomy.
Journal of endourology / Endourological Society 2007;21(12):1509-15.
2007: Niels F M Kok; Jan N M Ijzermans; Olaf Schouten; Khe T C Tran; Willem Weimar; Ian P J Alwayn
Laparoscopic donor nephrectomy in obese donors: easier to implement in overweight women?
Transplant international : official journal of the European Society for Organ Transplantation 2007;20(11):956-61.
2007: Paul Beaudry; Yasuhiro Hida; Taturo Udagawa; Ian P J Alwayn; Arin K Greene; Danielle A Arsenault; Judah Folkman; John V Heymach; Sandra W Ryeom; Mark Puder
Endothelial progenitor cells contribute to accelerated liver regeneration.
Journal of pediatric surgery 2007;42(7):1190-8.
2007: Ian P J Alwayn; Robert J Porte
How to make steatotic livers suitable for transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2007;13(4):480-2.
2006: Dirk J van der Windt; Niels F M Kok; Shahid M Hussain; pieter zondervan; Ian P J Alwayn; Robert A de Man; Jan N M Ijzermans
Case-orientated approach to the management of hepatocellular adenoma.
The British journal of surgery 2006;93(12):1495-502.
2006: Ian P J Alwayn; Charlotte Andersson; Sang Lee; Danielle A Arsenault; Bruce R Bistrian; Kathleen M Gura; Vania Nose; Blanca Zauscher; Marsha A Moses; Mark Puder
Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(6):G1011-9.
2006: Niels F M Kok; Ian P J Alwayn; Khe T C Tran; Wim C J Hop; Willem Weimar; Jan N M Ijzermans
Psychosocial and physical impairment after mini-incision open and laparoscopic donor nephrectomy: A prospective study.
Transplantation 2006;82(10):1291-7.
2006: Niels F M Kok; Willem Weimar; Ian P J Alwayn; Jan N M Ijzermans
The current practice of live donor nephrectomy in Europe.
Transplantation 2006;82(7):892-7.
2006: V E de Meijer; Cornelis Verhoef; Jan-Willem Kuiper; Ian P J Alwayn; G Kazemier; Jan N M Ijzermans
Radiofrequency ablation in patients with primary and secondary hepatic malignancies.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2006;10(7):960-73.
2006: Niels F M Kok; Ian P J Alwayn; Jan N M Ijzermans
[The first 100 hand-assisted laparoscopic donor nephrectomies at the Academic Medical Center in Amsterdam].
Nederlands tijdschrift voor geneeskunde 2006;150(25):1427-8; author reply 1428.
2006: Niels F M Kok; Ian P J Alwayn; Olaf Schouten; Khe T C Tran; Willem Weimar; Jan N M Ijzermans
Mini-incision open donor nephrectomy as an alternative to classic lumbotomy: evolution of the open approach.
Transplant international : official journal of the European Society for Organ Transplantation 2006;19(6):500-5.
2006: Niels F M Kok; Ian P J Alwayn; May Y Lind; Khe T C Tran; Willem Weimar; Jan N M Ijzermans
Donor nephrectomy: mini-incision muscle-splitting open approach versus laparoscopy.
Transplantation 2006;81(6):881-7.
2005: May Y Lind; Ingrid Mertens Zur Borg; Eric J Hazebroek; Wim C J Hop; Ian P J Alwayn; Willem Weimar; Jan N M Ijzermans
The effect of laparoscopic and open donor nephrectomy on the long-term renal function in donor and recipient: a retrospective study.
Transplantation 2005;80(5):700-3.
2005: Patrick J Javid; Arin K Greene; Jennifer J Garza; Kathleen M Gura; Ian P J Alwayn; Stephen Voss; Vania Nose; Ronit Satchi-Fainaro; Blanca Zausche; Robert V Mulkern; Tom Jaksic; Bruce R Bistrian; Judah Folkman; Mark Puder
The route of lipid administration affects parenteral nutrition-induced hepatic steatosis in a mouse model.
Journal of pediatric surgery 2005;40(9):1446-53.
2005: Arin K Greene; Ian P J Alwayn; Vania Nose; Evelyn Flynn; David Sampson; David Zurakowski; Judah Folkman; Mark Puder
Prevention of intra-abdominal adhesions using the antiangiogenic COX-2 inhibitor celecoxib.
Annals of surgery 2005;242(1):140-6.
2005: Ian P J Alwayn; Charlotte Andersson; Blanca Zauscher; Kathleen M Gura; Vânia Nosé; Mark Puder
Omega-3 fatty acids improve hepatic steatosis in a murine model: potential implications for the marginal steatotic liver donor.
Transplantation 2005;79(5):606-8.
2005: Ian P J Alwayn; Kathleen M Gura; Vânia Nosé; Blanca Zausche; Patrick J Javid; Jennifer J Garza; Jennifer Verbesey; Stephan Voss; Mario Ollero; Charlotte Andersson; Bruce R Bistrian; Judah Folkman; Mark Puder
Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease.
Pediatric research 2005;57(3):445-52.
2004: Ian P J Alwayn; Patrick J Javid; Kathleen M Gura; Vânia Nosé; Mario Ollero; Mark Puder
Do polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREPB-1 suppression or by correcting essential fatty acid deficiency.
Hepatology (Baltimore, Md.) 2004;39(4):1176-7; author reply 1177-8.
2003: Katsuhito Teranishi; Ian P J Alwayn; Leo H Bühler; Bernd Gollackner; Christoph Knosalla; Jennifer Huck; Rudolf O Duthaler; Andreas G Katopodis; David H Sachs; Henk-Jan Schuurman; Michel Awwad; David K C Cooper
Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons.
Xenotransplantation 2003;10(4):357-67.
2003: Bernd Gollackner; Ryan David; Christoph Knosalla; MR Basker; Ian P J Alwayn; David Harper; G Salomon; Shamila Mauiyyedi; LE Correa; Aron D Thall; David K C Cooper
An exploratory investigation of the effect of arsenic trioxide on anti-Gal antibody production in baboons.
Xenotransplantation 2003;10(1):80-7.
2002: Katsuhito Teranishi; Ian P J Alwayn; Leo H Bühler; Bernd Gollackner; Christoph Knosalla; LE Correa; Julian D Down; Mary E White-Scharf; David H Sachs; Rudolf O Duthaler; Andreas G Katopodis; Michel Awwad; David K C Cooper
Depletion of natural anti-pig antibodies by the continuous infusion of oligosaccharides in a pig-to-baboon model.
Transplantation proceedings 2002;34(7):2757-8.
2002: Leo H Bühler; Barbara Kurilla-Mahon; Qing Chang; Sonny Abraham; Ian P J Alwayn; James Z Appel; Dawne Newman; Michel Awwad; Mary E White-Scharf; Robert Sackstein; David H Sachs; David K C Cooper; Julian D Down
Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells.
Transplantation 2002;74(8):1159-66.
2002: Isabel M McMorrow; Leo Buhler; Sarah Treter; Francisca A Neethling; Ian P J Alwayn; Christopher A Comrack; Hiroshi Kitamura; Michel Awwad; Harout DerSimonian; David K C Cooper; David H Sachs; Christian Leguern
Modulation of the in vivo primate anti-Gal response through administration of anti-idiotypic antibodies.
Xenotransplantation 2002;9(2):106-14.
2002: Leo H Bühler; Michel Awwad; Sarah Treter; Qing Chang; MR Basker; Ian P J Alwayn; Katsuhito Teranishi; Thomas A Ericsson; Kathleen Moran; David Harper; Barbara Kurilla-Mahon; Christene A Huang; Robert Sackstein; Megan Sykes; Mary E White-Scharf; David H Sachs; Julian D Down; David K C Cooper
Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade.
Transplantation 2002;73(1):12-22.
2002: Leo H Bühler; S Deng; J O'Neil; Hiroshi Kitamura; Maria Koulmanda; A Baldi; J Rahier; Ian P J Alwayn; James Z Appel; Michel Awwad; David H Sachs; Gordon C Weir; J P Squifflet; David K C Cooper; Ph Morel
Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade.
Xenotransplantation 2002;9(1):3-13.
2001: Leo H Bühler; Ian P J Alwayn; MR Basker; G Oravec; Aron D Thall; Mary E White-Scharf; David H Sachs; Michel Awwad; David K C Cooper
CD40-CD154 pathway blockade requires host macrophages to induce humoral unresponsiveness to pig hematopoietic cells in baboons.
Transplantation 2001;72(11):1759-68.
2001: Leo H Bühler; Kazuhiko Yamada; Hiroshi Kitamura; Ian P J Alwayn; MR Basker; James Z Appel; Robert B Colvin; Mary E White-Scharf; David H Sachs; Simon C Robson; Michel Awwad; David K C Cooper
Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation.
Transplantation 2001;72(11):1743-52.
2001: Katsuhito Teranishi; Sarah Treter; Ian P J Alwayn; Leo Buhler; Michel Awwad; David K C Cooper
Assessment of methotrexate as a potential immunosuppressive agent in baboons.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2001;20(12):1335-9.
2001: James Z Appel; Ian P J Alwayn; LE Correa; David K C Cooper; Simon C Robson
Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. II. The effects of cyclophosphamide on pig peripheral blood progenitor cell-induced aggregation.
Transplantation 2001;72(7):1306-10.
2001: James Z Appel; Ian P J Alwayn; Leo Buhler; H A DeAngelis; Simon C Robson; David K C Cooper
Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells.
Transplantation 2001;72(7):1299-305.
2001: MR Basker; Ian P J Alwayn; Leo Buhler; David Harper; Sonny Abraham; Huw S Kruger Gray; H DeAngelis; Michel Awwad; Julian D Down; Robert Rieben; Mary E White-Scharf; David H Sachs; Aron D Thall; David K C Cooper
Clearance of mobilized porcine peripheral blood progenitor cells is delayed by depletion of the phagocytic reticuloendothelial system in baboons.
Transplantation 2001;72(7):1278-85.
2001: Ian P J Alwayn; Y Xu; MR Basker; C Wu; Leo Buhler; D Lambrigts; Sarah Treter; David Harper; Hiroshi Kitamura; E S Vitetta; Sonny Abraham; Michel Awwad; Mary E White-Scharf; David H Sachs; Aron D Thall; David K C Cooper
Effects of specific anti-B and/or anti-plasma cell immunotherapy on antibody production in baboons: depletion of CD20- and CD22-positive B cells does not result in significantly decreased production of anti-alphaGal antibody.
Xenotransplantation 2001;8(3):157-71.
2001: Ian P J Alwayn; Leo Buhler; James Z Appel; C Goepfert; Eva Csizmadia; LE Correa; David Harper; Hiroshi Kitamura; Julian D Down; Michel Awwad; Robert Sackstein; David K C Cooper; Simon C Robson
Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation.
Transplantation 2001;71(11):1601-9.
2001: Leo H Bühler; C Goepfert; Hiroshi Kitamura; MR Basker; Satoshi Gojo; Ian P J Alwayn; Qing Chang; Julian D Down; H Tsai; R Wise; David H Sachs; David K C Cooper; Simon C Robson; Robert Sackstein
Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy.
Bone marrow transplantation 2001;27(12):1227-36.
2001: L Buhler; Ian P J Alwayn; J Z Appel; S C Robson; D K Cooper
Anti-CD154 monoclonal antibody and thromboembolism.
Transplantation 2001;71(3):491.
2001: Leo H Bühler; Kazuhiko Yamada; Ian P J Alwayn; H Kitamura; MR Basker; Rolf N Barth; James Z Appel; Michel Awwad; Aron D Thall; Mary E White-Scharf; David H Sachs; David K C Cooper
Miniature swine and hDAF pig kidney transplantation in baboons treated with a nonmyeloablative regimen and CD154 blockade.
Transplantation proceedings 2001;33(1-2):716.
2000: J Z Appel; Ian P J Alwayn; D K Cooper
Xenotransplantation: the challenge to current psychosocial attitudes.
Progress in transplantation (Aliso Viejo, Calif.) 2000;10(4):217-25.
2000: Leo H Bühler; MR Basker; Ian P J Alwayn; C Goepfert; Hiroshi Kitamura; Tatsuo Kawai; Satoshi Gojo; Tomasz Kozlowski; Francesco L Ierino; Michel Awwad; David H Sachs; Robert Sackstein; Simon C Robson; David K C Cooper
Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates.
Transplantation 2000;70(9):1323-31.
2000: Ian P J Alwayn; James Z Appel; C Goepfert; Leo Buhler; David K C Cooper; Simon C Robson
Inhibition of platelet aggregation in baboons: therapeutic implications for xenotransplantation.
Xenotransplantation 2000;7(4):247-57.
2000: A Watts; A Foley; Michel Awwad; Sarah Treter; G Oravec; Leo Buhler; Ian P J Alwayn; Tomasz Kozlowski; D Lambrigts; Satoshi Gojo; MR Basker; Mary E White-Scharf; David Andrews; David H Sachs; David K C Cooper
Plasma perfusion by apheresis through a Gal immunoaffinity column successfully depletes anti-Gal antibody: experience with 320 aphereses in baboons.
Xenotransplantation 2000;7(3):181-5.
2000: Leo H Bühler; Sarah Treter; Isabel M McMorrow; Francisca A Neethling; Ian P J Alwayn; Michel Awwad; Aron D Thall; David K C Cooper; Christian Leguern; David H Sachs
Injection of porcine anti-idiotypic antibodies to primate anti-Gal antibodies leads to active inhibition of serum cytotoxicity in a baboon.
Transplantation proceedings 2000;32(5):1102.
2000: Ian P J Alwayn; Leo Buhler; MR Basker; C Goepfert; Tatsuo Kawai; Tomasz Kozlowski; Francesco L Ierino; David H Sachs; Robert Sackstein; Simon C Robson; David K C Cooper
Coagulation/thrombotic disorders associated with organ and cell xenotransplantation.
Transplantation proceedings 2000;32(5):1099.
2000: MR Basker; Ian P J Alwayn; Sarah Treter; David Harper; Leo Buhler; David Andrews; Aron D Thall; D Lambrigts; Michel Awwad; Mary E White-Scharf; David H Sachs; David K C Cooper
Effect of B cell/plasma cell depletion or suppression on anti-Gal antibody in the baboon.
Transplantation proceedings 2000;32(5):1009.
2000: C Gopfert; Leo Buhler; R Wise; MR Basker; Satoshi Gojo; M Imai; Ian P J Alwayn; D H Sachs; Robert Sackstein; D K Cooper; Simon C Robson
Von willebrand factor concentration, multimeric patterns, and cleaving protease activity in baboons undergoing xenogeneic peripheral blood stem cell transplantation.
Transplantation proceedings 2000;32(5):990.
2000: MR Basker; Leo Buhler; Ian P J Alwayn; James Z Appel; David K C Cooper
Pharmacotherapeutic agents in xenotransplantation.
Expert opinion on pharmacotherapy 2000;1(4):757-69.
1999: Ian P J Alwayn; MR Basker; Leo Buhler; David K C Cooper
The problem of anti-pig antibodies in pig-to-primate xenografting: current and novel methods of depletion and/or suppression of production of anti-pig antibodies.
Xenotransplantation 1999;6(3):157-68.