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Raul DeLa Cadena

Research Profile

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Mario C Rico; James J Rough; Fayez F Safadi; Fabiola Del Carpio-Cano; Satya P Kunapuli; Joanne M Manns; Raul A DeLa Cadena
Assembly of the prothrombinase complex on the surface of human foreskin fibroblasts: Implications for connective tissue growth factor.
Elys Viera; Raquel Diaz; Angel Pagan; Mario C Rico; Yadira Alonso; Joey Armas; Dayan Colón; Fabiola Del Carpio-Cano; Raul A DeLa Cadena
Improving patient provider communication for Latinos at Temple University Hospital and Temple University School of Medicine.
Oneida A Arosarena; Fabiola E Del Carpio-Cano; Raul A DeLa Cadena; Emeka Nwodim; Mario C Rico; Fayez F Safadi
Comparison of bone morphogenetic protein-2 and osteoactivin for mesenchymal cell differentiation: effects of bolus and continuous administration.

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2012: Mario C Rico; James J Rough; Fayez F Safadi; Fabiola Del Carpio-Cano; Satya P Kunapuli; Joanne M Manns; Raul A DeLa Cadena
Assembly of the prothrombinase complex on the surface of human foreskin fibroblasts: Implications for connective tissue growth factor.
Thrombosis research 2012;129(6):801-6.
2011: Elys Viera; Raquel Diaz; Angel Pagan; Mario C Rico; Yadira Alonso; Joey Armas; Dayan Colón; Fabiola Del Carpio-Cano; Raul A DeLa Cadena
Improving patient provider communication for Latinos at Temple University Hospital and Temple University School of Medicine.
Journal of health care for the poor and underserved 2011;22(4):1144-50.
2011: Oneida A Arosarena; Fabiola E Del Carpio-Cano; Raul A DeLa Cadena; Emeka Nwodim; Mario C Rico; Fayez F Safadi
Comparison of bone morphogenetic protein-2 and osteoactivin for mesenchymal cell differentiation: effects of bolus and continuous administration.
Journal of cellular physiology 2011;226(11):2943-52.
2011: Analia E Garcia; Sripal R Mada; Mario C Rico; Raul A DeLa Cadena; Satya P Kunapuli
Clopidogrel, a P2Y12 receptor antagonist, potentiates the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis.
PloS one 2011;6(10):e26035.
2010: Mario C Rico; James J Rough; Fabiola E Del Carpio-Cano; Satya P Kunapuli; Raul A DeLa Cadena
The axis of thrombospondin-1, transforming growth factor beta and connective tissue growth factor: an emerging therapeutic target in rheumatoid arthritis.
Current vascular pharmacology 2010;8(3):338-43.
2008: Mario C Rico; Joanne M Manns; Jeffrey B Driban; Audrey B Uknis; Satya P Kunapuli; Raul A DeLa Cadena
Thrombospondin-1 and transforming growth factor beta are pro-inflammatory molecules in rheumatoid arthritis.
Translational research : the journal of laboratory and clinical medicine 2008;152(2):95-8.
2007: Mario C Rico; Julian L Castaneda; Joanne M Manns; Audrey B Uknis; Irma M Sainz; Fayez F Safadi; Steven N Popoff; Raul A DeLa Cadena
Amelioration of inflammation, angiogenesis and CTGF expression in an arthritis model by a TSP1-derived peptide treatment.
Journal of cellular physiology 2007;211(2):504-12.
2006: Joanne M Manns; Audrey B Uknis; Mario C Rico; Alexis Agelan; Julian L Castaneda; Israel Arango; Mary F Barbe; Fayez F Safadi; Steven N Popoff; Raul A DeLa Cadena
A peptide from thrombospondin 1 modulates experimental erosive arthritis by regulating connective tissue growth factor.
Arthritis and rheumatism 2006;54(8):2415-22.
2005: Irma M Sainz; Irma Isordia-Salas; Julian L Castaneda; Alexis Agelan; Bo Liu; Raul A DeLa Cadena; Robin A Pixley; Albert Adam; Ryan Sartor; Robert W Colman
Modulation of inflammation by kininogen deficiency in a rat model of inflammatory arthritis.
Arthritis and rheumatism 2005;52(8):2549-52.
2005: Irma Isordia-Salas; Joanne M Manns; Irma M Sainz; Hemant Parekh; Raul A DeLa Cadena
Thromsbospondin-1 binds to the heavy chain of elastase activated coagulation factor V (FVaHNE) and enhances thrombin generation on the surface of a promyelocytic cell line.
Thrombosis research 2005;116(6):533-43.
2004: Ricardo G Espinola; Audrey B Uknis; Irma M Sainz; Irma Isordia-Salas; Robin A Pixley; Raul A DeLa Cadena; Walter Long; Alexis Agelan; John Gaughan; Albert Adam; Robert W Colman
A monoclonal antibody to high-molecular weight kininogen is therapeutic in a rodent model of reactive arthritis.
The American journal of pathology 2004;165(3):969-76.
2004: Irma M Sainz; Audrey B Uknis; Irma Isordia-Salas; Raul A DeLa Cadena; Robin A Pixley; Robert W Colman
Interactions between bradykinin (BK) and cell adhesion molecule (CAM) expression in peptidoglycan-polysaccharide (PG-PS)-induced arthritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):887-9.
2001: Audrey B Uknis; Raul A DeLa Cadena; R Janardham; Ryan Sartor; E T Whalley; Robert W Colman
Bradykinin receptor antagonists type 2 attenuate the inflammatory changes in peptidoglycan-induced acute arthritis in the Lewis rat.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2001;50(3):149-55.
2001: Tarek E Selim; Hayam R Ghoneim; H A Abdel Ghaffar; Robert W Colman; Raul A DeLa Cadena
High molecular mass kininogen inhibits cathepsin G-induced platelet activation by forming a complex with cathepsin G.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(6):371-7.
2000: A Majluf-Cruz; Joanne M Manns; Audrey B Uknis; X Yang; Robert W Colman; R B Harris; W Frazier; J Lawler; Raul A DeLa Cadena
Residues F16-G33 and A784-N823 within platelet thrombospondin-1 play a major role in binding human neutrophils: evaluation by two novel binding assays.
The Journal of laboratory and clinical medicine 2000;136(4):292-302.
1998: P L Harper; Fletcher B Taylor; Raul A DeLa Cadena; M Courtney; R W Colman; R W Carrell
Recombinant antitrypsin Pittsburgh undergoes proteolytic cleavage during E. coli sepsis and fails to prevent the associated coagulopathy in a primate model.
Thrombosis and haemostasis 1998;80(5):816-21.
1998: R Kaplan; Raul A DeLa Cadena
Mechanism of the coagulopathy associated with acute promyelocytic leukemia -clinical conference-.
American journal of hematology 1998;59(3):234-7.
1998: Raul A DeLa Cadena; A Majluf-Cruz; Antoni Stadnicki; Margaret Tropea; Debra Reda; J M Agosti; Robert W Colman; Anthony F Suffredini
Recombinant tumor necrosis factor receptor p75 fusion protein (TNFR:Fc) alters endotoxin-induced activation of the kinin, fibrinolytic, and coagulation systems in normal humans.
Thrombosis and haemostasis 1998;80(1):114-8.
1998: Robert W Colman; Ryan Sartor; AA Adam; Raul A DeLa Cadena; Antoni Stadnicki
The plasma kallikrein-kinin system in sepsis, inflammatory arthritis, and enterocolitis.
Clinical reviews in allergy & immunology 1998;16(4):365-84.
1998: Raul A DeLa Cadena; Satya P Kunapuli; D A Walz; Robert W Colman
Expression of thrombospondin 1 on the surface of activated platelets mediates their interaction with the heavy chains of human kininogens through Lys 244-Pro 254.
Thrombosis and haemostasis 1998;79(1):186-94.
1997: Tarek E Selim; Hayam R Ghoneim; Audrey B Uknis; Robert W Colman; Raul A DeLa Cadena
High-molecular-mass and low-molecular-mass kininogens block plasmin-induced platelet aggregation by forming a complex with kringle 5 of plasminogen/plasmin.
European journal of biochemistry / FEBS 1997;250(2):532-8.
1997: Antoni Stadnicki; Maciej Gonciarz; T J Niewiarowski; J Hartleb; M Rudnicki; N B Merrell; Raul A DeLa Cadena; Robert W Colman
Activation of plasma contact and coagulation systems and neutrophils in the active phase of ulcerative colitis.
Digestive diseases and sciences 1997;42(11):2356-66.
1997: Harlan N Bradford; Raul A DeLa Cadena; Satya P Kunapuli; J F Dong; J A Löpez; Robert W Colman
Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex.
Blood 1997;90(4):1508-15.
1997: Robert W Colman; Antoni Stadnicki; Charles Kettner; AA Adam; Raul A DeLa Cadena; Ryan Sartor
Activation of the kallikrein-kinin system in arthritis and enterocolitis in genetically susceptible rats: modulation by a selective plasma kallikrein inhibitor.
Proceedings of the Association of American Physicians 1997;109(1):10-22.
1996: Antoni Stadnicki; Raul A DeLa Cadena; Ryan Sartor; Charles Kettner; Robert W Colman
The contact system in experimental enterocolitis.
Immunopharmacology 1996;33(1-3):314-6.
1996: Raul A DeLa Cadena; A Majluf-Cruz; Antoni Stadnicki; J M Agosti; Robert W Colman; Anthony F Suffredini
Activation of the contact and fibrinolytic systems after intravenous administration of endotoxin to normal human volunteers: correlation with the cytokine profile.
Immunopharmacology 1996;33(1-3):231-7.
1996: Satya P Kunapuli; H N Bradford; B A Jameson; Raul A DeLa Cadena; L Rick; R P Wassell; Robert W Colman
Thrombin-induced platelet aggregation is inhibited by the heptapeptide Leu271-Ala277 of domain 3 in the heavy chain of high molecular weight kininogen.
The Journal of biological chemistry 1996;271(19):11228-35.
1996: Robert W Colman; H N Bradford; Satya P Kunapuli; Raul A DeLa Cadena; L Rick; B A Jameson; R P Wassell
Leu271-Glu292 in kininogens blocks thrombin-induced aggregation.
Immunopharmacology 1996;32(1-3):80-1.
1996: Antoni Stadnicki; Raul A DeLa Cadena; Ryan Sartor; D Bender; Charles Kettner; Heiko C Rath; AA Adam; Robert W Colman
Selective plasma kallikrein inhibitor attenuates acute intestinal inflammation in Lewis rat.
Digestive diseases and sciences 1996;41(5):912-20.
1996: Ryan Sartor; Raul A DeLa Cadena; K D Green; Antoni Stadnicki; S W Davis; J H Schwab; A A Adam; P Raymond; R W Colman
Selective kallikrein-kinin system activation in inbred rats differentially susceptible to granulomatous enterocolitis.
Gastroenterology 1996;110(5):1467-81.
1995: Raul A DeLa Cadena
Fletcher factor deficiency in a 9-year-old girl: mechanisms of the contact pathway of blood coagulation.
American journal of hematology 1995;48(4):273-7.
1995: Raul A DeLa Cadena; Antoni Stadnicki; A B Uknis; Ryan Sartor; Charles Kettner; AA Adam; Robert W Colman
Inhibition of plasma kallikrein prevents peptidoglycan-induced arthritis in the Lewis rat.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(5):446-52.
1995: R A Pixley; S Zellis; P Bankes; Raul A DeLa Cadena; J D Page; CF Scott; J Kappelmayer; E G Wyshock; J J Kelly; Robert W Colman
Prognostic value of assessing contact system activation and factor V in systemic inflammatory response syndrome.
Critical care medicine 1995;23(1):41-51.
1994: Y T Wachtfogel; Raul A DeLa Cadena; Satya P Kunapuli; L Rick; M Miller; R L Schultze; D C Altieri; T S Edgington; Robert W Colman
High molecular weight kininogen binds to Mac-1 on neutrophils by its heavy chain (domain 3) and its light chain (domain 5).
The Journal of biological chemistry 1994;269(30):19307-12.
1994: Raul A DeLa Cadena; E G Wyshock; Satya P Kunapuli; R L Schultze; M Miller; D A Walz; Robert W Colman
Platelet thrombospondin interactions with human high and low molecular weight kininogens.
Thrombosis and haemostasis 1994;72(1):125-31.
1994: J D Page; Raul A DeLa Cadena; J E Humphries; Robert W Colman
An autoantibody to human plasma prekallikrein blocks activation of the contact system.
British journal of haematology 1994;87(1):81-6.
1994: John W Weisel; Chandrasekaran Nagaswami; J L Woodhead; Raul A DeLa Cadena; J D Page; Robert W Colman
The shape of high molecular weight kininogen. Organization into structural domains, changes with activation, and interactions with prekallikrein, as determined by electron microscopy.
The Journal of biological chemistry 1994;269(13):10100-6.
1993: Y T Wachtfogel; Raul A DeLa Cadena; Robert W Colman
Structural biology, cellular interactions and pathophysiology of the contact system.
Thrombosis research 1993;72(1):1-21.
1993: Raul A DeLa Cadena; Anthony F Suffredini; J D Page; R A Pixley; N Kaufman; J E Parrillo; Robert W Colman
Activation of the kallikrein-kinin system after endotoxin administration to normal human volunteers.
Blood 1993;81(12):3313-7.
1993: Satya P Kunapuli; Raul A DeLa Cadena; Robert W Colman
Deletion mutagenesis of high molecular weight kininogen light chain. Identification of two anionic surface binding subdomains.
The Journal of biological chemistry 1993;268(4):2486-92.
1992: Satya P Kunapuli; Raul A DeLa Cadena; Robert W Colman
Bacterial expression of biologically active high molecular weight kininogen light chain.
Thrombosis and haemostasis 1992;67(4):428-33.
1992: R A Pixley; Raul A DeLa Cadena; J D Page; N Kaufman; E G Wyshock; Robert W Colman; A Chang; Fletcher B Taylor
Activation of the contact system in lethal hypotensive bacteremia in a baboon model.
The American journal of pathology 1992;140(4):897-906.
1992: Raul A DeLa Cadena; Ryan Sartor; AA Adam; B Raymond; F Legris; Robert W Colman
Role of kallikrein-kinin system in the pathogenesis of bacterial cell wall-induced inflammation and enterocolitis.
Transactions of the Association of American Physicians 1992;105():229-37.
1992: Raul A DeLa Cadena; Robert W Colman
The sequence HGLGHGHEQQHGLGHGH in the light chain of high molecular weight kininogen serves as a primary structural feature for zinc-dependent binding to an anionic surface.
Protein science : a publication of the Protein Society 1992;1(1):151-60.
1991: Raul A DeLa Cadena; Robert W Colman
Structure and functions of human kininogens.
Trends in pharmacological sciences 1991;12(7):272-5.
1991: Raul A DeLa Cadena; K J Laskin; R A Pixley; Ryan Sartor; J H Schwab; N Back; G S Bedi; Robert S Fisher; Robert W Colman
Role of kallikrein-kinin system in pathogenesis of bacterial cell wall-induced inflammation.
The American journal of physiology 1991;260(2 Pt 1):G213-9.