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Frank DeLeo

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Scott D Kobayashi; Frank R DeLeo
Systems biology and innate immunity.
Justin T Schwartz; Adeline R Whitney; Sarmistha Bandyopadhyay; Frank R DeLeo; Scott D Kobayashi; Jenna McCracken; Lee-Ann H Allen
Francisella tularensis alters human neutrophil gene expression: insights into the molecular basis of delayed neutrophil apoptosis.
Natalia Malachowa; Michael J Parnell; Adeline R Whitney; Kevin R Braughton; Donald J Gardner; Scott D Kobayashi; Frank R DeLeo
Staphylococcus aureus leukotoxin GH promotes inflammation.

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All Publications

2013: Scott D Kobayashi; Frank R DeLeo
Systems biology and innate immunity.
Journal of innate immunity 2013;5(2):97-9.
2013: Justin T Schwartz; Adeline R Whitney; Sarmistha Bandyopadhyay; Frank R DeLeo; Scott D Kobayashi; Jenna McCracken; Lee-Ann H Allen
Francisella tularensis alters human neutrophil gene expression: insights into the molecular basis of delayed neutrophil apoptosis.
Journal of innate immunity 2013;5(2):124-36.
2012: Natalia Malachowa; Michael J Parnell; Adeline R Whitney; Kevin R Braughton; Donald J Gardner; Scott D Kobayashi; Frank R DeLeo
Staphylococcus aureus leukotoxin GH promotes inflammation.
The Journal of infectious diseases 2012;206(8):1185-93.
2012: Shawna F Graves; Liliya N Kirpotina; Scott D Kobayashi; Mark T Quinn; Devon L Rasmussen; Daniel E Sturdevant; Adeline R Whitney; Kevin R Braughton; Frank R DeLeo
Sublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human PMN gene expression and enhance bactericidal capacity.
Journal of leukocyte biology 2012;92(2):361-74.
2012: Scott D Kobayashi; Frank R DeLeo
Inflammation in 3D.
Cell host & microbe 2012;11(6):557-9.
2012: Kevin M Rigby; Frank R DeLeo
Neutrophils in innate host defense against Staphylococcus aureus infections.
Seminars in immunopathology 2012;34(2):237-59.
2012: Thea Lu; Mark T Quinn; Scott D Kobayashi; Frank R DeLeo
A NET Outcome.
Frontiers in immunology 2012;3():365.
2012: Anne-Catrin Uhlemann; Frank R DeLeo; Adam D Kennedy; Craig Martens; Stephen F Porcella; Franklin D Lowy
Toward an understanding of the evolution of Staphylococcus aureus strain USA300 during colonization in community households.
Genome biology and evolution 2012;4(12):1275-85.
2012: Scott D Kobayashi; James M Musser; Frank R DeLeo
Genomic analysis of the emergence of vancomycin-resistant Staphylococcus aureus.
mBio 2012;3(4):.
2012: Anne-Catrin Uhlemann; Alex J McCarthy; Stephen F Porcella; Craig Street; Sean B Sullivan; Sheetal Trivedi; Kent D Barbian; Frank R DeLeo; Cory Hafer; David L Hirschberg; Adam D Kennedy; Jodi A Lindsay; W Ian Lipkin; Franklin D Lowy
Identification of a highly transmissible animal-independent Staphylococcus aureus ST398 clone with distinct genomic and cell adhesion properties.
mBio 2012;3(2):.
2011: Frank R DeLeo; Adam D Kennedy; Scott D Kobayashi; Kevin R Braughton; Juliane Bubeck Wardenburg; Liang Chen; Craig A Martens; Barun Mathema; Martin J McGavin; James M Musser; Michael Otto; Stephen F Porcella; Amer E Villaruz; Adeline R Whitney; Barry N Kreiswirth
Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(44):18091-6.
2011: Scott D Kobayashi; Dan Long; Natalia Malachowa; Michael Otto; Olaf Schneewind; Adeline R Whitney; Kevin R Braughton; Juliane Bubeck Wardenburg; Donald J Gardner; Frank R DeLeo
Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection.
The Journal of infectious diseases 2011;204(6):937-41.
2011: Scott D Kobayashi; Frank R DeLeo
A MRSA-terious enemy among us: boosting MRSA vaccines.
Nature medicine 2011;17(2):168-9.
2011: Natalia Malachowa; Adeline R Whitney; Scott D Kobayashi; Daniel E Sturdevant; Adam D Kennedy; Kevin R Braughton; Duncan W Shabb; Binh An Diep; Henry F Chambers; Michael Otto; Frank R DeLeo
Global changes in Staphylococcus aureus gene expression in human blood.
PloS one 2011;6(4):e18617.
2010: Adam D Kennedy; Stephen F Porcella; Craig Martens; Adeline R Whitney; Kevin R Braughton; Liang Chen; Carly T Craig; Fred C Tenover; Barry N Kreiswirth; James M Musser; Frank R DeLeo
Complete nucleotide sequence analysis of plasmids in strains of Staphylococcus aureus clone USA300 reveals a high level of identity among isolates with closely related core genome sequences.
Journal of clinical microbiology 2010;48(12):4504-11.
2010: Adam D Kennedy; Juliane Bubeck Wardenburg; Donald J Gardner; Daniel Long; Adeline R Whitney; Kevin R Braughton; Olaf Schneewind; Frank R DeLeo
Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model.
The Journal of infectious diseases 2010;202(7):1050-8.
2010: Natalia Malachowa; Frank R DeLeo
Mobile genetic elements of Staphylococcus aureus.
Cellular and molecular life sciences : CMLS 2010;67(18):3057-71.
2010: Shawna F Graves; Scott D Kobayashi; Kevin R Braughton; Binh An Diep; Henry F Chambers; Michael Otto; Frank R DeLeo
Relative contribution of Panton-Valentine leukocidin to PMN plasma membrane permeability and lysis caused by USA300 and USA400 culture supernatants.
Microbes and infection / Institut Pasteur 2010;12(6):446-56.
2010: Frank R DeLeo; Michael Otto; Barry N Kreiswirth; Henry F Chambers
Community-associated meticillin-resistant Staphylococcus aureus.
Lancet 2010;375(9725):1557-68.
2010: Binh An Diep; Liana Chan; Pierre Tattevin; Osamu Kajikawa; Thomas R Martin; Li Basuino; Thuy T Mai; Helene Marbach; Kevin R Braughton; Adeline R Whitney; Donald J Gardner; Xuemo Fan; Ching W Tseng; George Y Liu; Cedric Badiou; Jerome Etienne; Gerard Lina; Michael A Matthay; Frank R DeLeo; Henry F Chambers
Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(12):5587-92.
2010: Patrick R Shea; Kimmo Virtaneva; John J Kupko; Stephen F Porcella; William T Barry; Fred A Wright; Scott D Kobayashi; Aaron Carmody; Robin M Ireland; Daniel E Sturdevant; Stacy M Ricklefs; Imran Babar; Claire A Johnson; Morag R Graham; Donald J Gardner; John R Bailey; Michael J Parnell; Frank R DeLeo; James M Musser
Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(10):4693-8.
2010: Randall J Olsen; Scott D Kobayashi; Ara A Ayeras; Madiha Ashraf; Shawna F Graves; Willie Ragasa; Tammy Humbird; Jamieson L Greaver; Constance Cantu; Jody L Swain; Leslie Jenkins; Terry Blasdel; Philip T Cagle; Donald J Gardner; Frank R DeLeo; James M Musser
Lack of a major role of Staphylococcus aureus Panton-Valentine leukocidin in lower respiratory tract infection in nonhuman primates.
The American journal of pathology 2010;176(3):1346-54.
2010: Donald Vinh; Smita Y Patel; Gulbu Uzel; Victoria L Anderson; Alexandra F Freeman; Kenneth N Olivier; Christine Spalding; Stephen Hughes; Stefania Pittaluga; Mark Raffeld; Lynn R Sorbara; Houda Z Elloumi; Douglas B Kuhns; Maria L Turner; Edward W Cowen; Danielle Fink; Debra Long-Priel; Amy P Hsu; Li Ding; Michelle L Paulson; Adeline R Whitney; Elizabeth P Sampaio; David M Frucht; Frank R DeLeo; Steven M Holland
Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia.
Blood 2010;115(8):1519-29.
2010: Shawna F Graves; Scott D Kobayashi; Frank R DeLeo
Community-associated methicillin-resistant Staphylococcus aureus immune evasion and virulence.
Journal of molecular medicine (Berlin, Germany) 2010;88(2):109-14.
2010: Randall J Olsen; Izabela Sitkiewicz; Ara A Ayeras; Vedia E Gonulal; Concepcion Cantu; Stephen B Beres; Nicole M Green; Benfang Lei; Tammy Humbird; Jamieson Greaver; Ellen Chang; Willie P Ragasa; Charles Montgomery; Joiner Cartwright; Allison McGeer; Donald E Low; Adeline R Whitney; Philip T Cagle; Terry L Blasdel; Frank R DeLeo; James M Musser
Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):888-93.
2010: Gordon Y C Cheung; Kevin Rigby; Rong Wang; Shu Y Queck; Kevin R Braughton; Adeline R Whitney; Martin Teintze; Frank R DeLeo; Michael Otto
Staphylococcus epidermidis strategies to avoid killing by human neutrophils.
PLoS pathogens 2010;6(10):e1001133.
2010: Christy L Ventura; Natalia Malachowa; Carl H Hammer; Glenn A Nardone; Mary Ann Robinson; Scott D Kobayashi; Frank R DeLeo
Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics.
PloS one 2010;5(7):e11634.
2010: Scott D Kobayashi; Kevin R Braughton; Amy M Palazzolo-Ballance; Adam D Kennedy; Elizabeth Sampaio; Ervand Kristosturyan; Adeline R Whitney; Daniel E Sturdevant; David W Dorward; Steven M Holland; Barry N Kreiswirth; James M Musser; Frank R DeLeo
Rapid neutrophil destruction following phagocytosis of Staphylococcus aureus.
Journal of innate immunity 2010;2(6):560-75.
2009: Scott D Kobayashi; Frank R DeLeo
Role of neutrophils in innate immunity: a systems biology-level approach.
Wiley interdisciplinary reviews. Systems biology and medicine 2009;1(3):309-33.
2009: Scott D Kobayashi; Frank R DeLeo
An update on community-associated MRSA virulence.
Current opinion in pharmacology 2009;9(5):545-51.
2009: Frank R DeLeo; Henry F Chambers
Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era.
The Journal of clinical investigation 2009;119(9):2464-74.
2009: Amer E Villaruz; Juliane Bubeck Wardenburg; Burhan A Khan; Adeline R Whitney; Daniel E Sturdevant; Donald J Gardner; Frank R DeLeo; Michael Otto
A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation.
The Journal of infectious diseases 2009;200(5):724-34.
2009: Shu Y Queck; Burhan A Khan; Rong Wang; Thanh-Huy L Bach; Dorothee Kretschmer; Liang Chen; Barry N Kreiswirth; Andreas Peschel; Frank R DeLeo; Michael Otto
Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA.
PLoS pathogens 2009;5(7):e1000533.
2009: Jovanka M Voyich; Cuong Vuong; Mark DeWald; Tyler K Nygaard; Stanislava Kocianova; Shannon Griffith; Jennifer Jones; Courtney Iverson; Daniel E Sturdevant; Kevin R Braughton; Adeline R Whitney; Michael Otto; Frank R DeLeo
The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus.
The Journal of infectious diseases 2009;199(11):1698-706.
2009: Min Li; Binh An Diep; Amer E Villaruz; Kevin R Braughton; Xiaofei Jiang; Frank R DeLeo; Henry F Chambers; Yuan Lu; Michael Otto
Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5883-8.
2009: Frank R DeLeo; Binh An Diep; Michael Otto
Host defense and pathogenesis in Staphylococcus aureus infections.
Infectious disease clinics of North America 2009;23(1):17-34.
2009: Adam D Kennedy; Frank R DeLeo
Neutrophil apoptosis and the resolution of infection.
Immunologic research 2009;43(1-3):25-61.
2008: Tyler K Nygaard; Frank R DeLeo; Jovanka M Voyich
Community-associated methicillin-resistant Staphylococcus aureus skin infections: advances toward identifying the key virulence factors.
Current opinion in infectious diseases 2008;21(2):147-52.
2008: Paul Sumby; Shizhen Zhang; Adeline R Whitney; Fabiana Falugi; Guido Grandi; Edward Graviss; Frank R DeLeo; James M Musser
A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response.
Infection and immunity 2008;76(3):978-85.
2008: Frank R DeLeo; Michael Otto
An antidote for Staphylococcus aureus pneumonia?
The Journal of experimental medicine 2008;205(2):271-4.
2008: Adam D Kennedy; Michael Otto; Kevin R Braughton; Adeline R Whitney; Liang Chen; Barun Mathema; Jose R Mediavilla; Kelly A Byrne; Larye D Parkins; Fred C Tenover; Barry N Kreiswirth; James M Musser; Frank R DeLeo
Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(4):1327-32.
2008: Stephen B Beres; Ricardo Sesso; Sergio Wyton L Pinto; Nancy P Hoe; Stephen F Porcella; Frank R DeLeo; James M Musser
Genome sequence of a Lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease.
PloS one 2008;3(8):e3026.
2008: Jovanka M Voyich; Dan E Sturdevant; Frank R DeLeo
Analysis of Staphylococcus aureus gene expression during PMN phagocytosis.
Methods in molecular biology (Clifton, N.J.) 2008;431():109-22.
2008: Amy M Palazzolo-Ballance; Michelle L Reniere; Kevin R Braughton; Daniel E Sturdevant; Michael Otto; Barry N Kreiswirth; Eric P Skaar; Frank R DeLeo
Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):500-9.
2007: Rong Wang; Kevin R Braughton; Dorothee Kretschmer; Thanh-Huy L Bach; Shu Y Queck; Min Li; Adam D Kennedy; David W Dorward; Seymour J Klebanoff; Andreas Peschel; Frank R DeLeo; Michael Otto
Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA.
Nature medicine 2007;13(12):1510-4.
2007: Steven M Holland; Frank R DeLeo; Houda Z Elloumi; Amy P Hsu; Gulbu Uzel; Nina Brodsky; Alexandra F Freeman; Andrew Demidowich; Joie Davis; Maria L Turner; Victoria L Anderson; Dirk Darnell; Pamela A Welch; Douglas B Kuhns; David M Frucht; Harry L Malech; John Gallin; Scott D Kobayashi; Adeline R Whitney; Jovanka M Voyich; James M Musser; Cristina Woellner; Alejandro A Schäffer; Jennifer M Puck; Bodo Grimbacher
STAT3 mutations in the hyper-IgE syndrome.
The New England journal of medicine 2007;357(16):1608-19.
2007: Frank R DeLeo
Attractive shedding.
Blood 2007;110(6):1711-2.
2007: Katherine A Gauss; Laura K Nelson-Overton; Daniel W Siemsen; Ying Gao; Frank R DeLeo; Mark T Quinn
Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha.
Journal of leukocyte biology 2007;82(3):729-41.
2007: Christopher Burlak; Carl H Hammer; Mary-Ann Robinson; Adeline R Whitney; Martin J McGavin; Barry N Kreiswirth; Frank R DeLeo
Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection.
Cellular microbiology 2007;9(5):1172-90.
2007: Adam D Kennedy; Janet A Willment; David W Dorward; David L Williams; Gordon D Brown; Frank R DeLeo
Dectin-1 promotes fungicidal activity of human neutrophils.
European journal of immunology 2007;37(2):467-78.
2007: Mark T Quinn; Frank R DeLeo; Gary M Bokoch
Neutrophil methods and protocols. Preface.
Methods in molecular biology (Clifton, N.J.) 2007;412():vii-viii.
2006: Jovanka M Voyich; Michael Otto; Barun Mathema; Kevin R Braughton; Adeline R Whitney; Diane M Welty; R Daniel Long; David W Dorward; Donald J Gardner; Gérard Lina; Barry N Kreiswirth; Frank R DeLeo
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
The Journal of infectious diseases 2006;194(12):1761-70.
2006: Samuel A Shelburne; Paul Sumby; Izabela Sitkiewicz; Nnaja Okorafor; Chanel Granville; Payal Patel; Jovanka M Voyich; Richard Hull; Frank R DeLeo; James M Musser
Maltodextrin utilization plays a key role in the ability of group A Streptococcus to colonize the oropharynx.
Infection and immunity 2006;74(8):4605-14.
2006: Mark T Quinn; Mary Cloud B Ammons; Frank R DeLeo
The expanding role of NADPH oxidases in health and disease: no longer just agents of death and destruction.
Clinical science (London, England : 1979) 2006;111(1):1-20.
2006: Stephen B Beres; Ellen W Richter; Michal J Nagiec; Paul Sumby; Stephen F Porcella; Frank R DeLeo; James M Musser
Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):7059-64.
2006: Cyril Guyard; James Battisti; Sandra J Raffel; Merry E Schrumpf; Adeline R Whitney; Jonathan G Krum; Stephen F Porcella; Patricia A Rosa; Frank R DeLeo; Tom G Schwan
Relapsing fever spirochaetes produce a serine protease that provides resistance to oxidative stress and killing by neutrophils.
Molecular microbiology 2006;60(3):710-22.
2006: Bruce Walcheck; Amy H Herrera; Catherine St Hill; Polly E Mattila; Adeline R Whitney; Frank R DeLeo
ADAM17 activity during human neutrophil activation and apoptosis.
European journal of immunology 2006;36(4):968-76.
2006: Christopher Burlak; Adeline R Whitney; David J Mead; Ted Hackstadt; Frank R DeLeo
Maturation of human neutrophil phagosomes includes incorporation of molecular chaperones and endoplasmic reticulum quality control machinery.
Molecular & cellular proteomics : MCP 2006;5(4):620-34.
2006: Katherine A Gauss; Peggy L Bunger; Matthew A Crawford; Breanne E McDermott; Robin Swearingen; Laura K Nelson-Overton; Daniel W Siemsen; Scott D Kobayashi; Frank R DeLeo; Mark T Quinn
Variants of the 5'-untranslated region of human NCF2: expression and translational efficiency.
Gene 2006;366(1):169-79.
2006: Paul Sumby; Adeline R Whitney; Edward Graviss; Frank R DeLeo; James M Musser
Genome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity.
PLoS pathogens 2006;2(1):e5.
2005: James M Musser; Frank R DeLeo
Toward a genome-wide systems biology analysis of host-pathogen interactions in group A Streptococcus.
The American journal of pathology 2005;167(6):1461-72.
2005: Scott D Kobayashi; Jovanka M Voyich; Adeline R Whitney; Frank R DeLeo
Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor.
Journal of leukocyte biology 2005;78(6):1408-18.
2005: Scott D Kobayashi; Jovanka M Voyich; Christopher Burlak; Frank R DeLeo
Neutrophils in the innate immune response.
Archivum immunologiae et therapiae experimentalis 2005;53(6):505-17.
2005: Samuel A Shelburne; Paul Sumby; Izabela Sitkiewicz; Chanel Granville; Frank R DeLeo; James M Musser
Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):16037-42.
2005: Jovanka M Voyich; Kevin R Braughton; Daniel E Sturdevant; Adeline R Whitney; Battouli Saïd-Salim; Stephen F Porcella; R Daniel Long; David W Dorward; Donald J Gardner; Barry N Kreiswirth; James M Musser; Frank R DeLeo
Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3907-19.
2005: Frank R DeLeo; B Joseph Hinnebusch
A plague upon the phagocytes.
Nature medicine 2005;11(9):927-8.
2005: Battouli Saïd-Salim; Barun Mathema; Kevin R Braughton; Stacy Davis; Daniel Sinsimer; William Eisner; Yekaterina Likhoshvay; Frank R DeLeo; Barry N Kreiswirth
Differential distribution and expression of Panton-Valentine leucocidin among community-acquired methicillin-resistant Staphylococcus aureus strains.
Journal of clinical microbiology 2005;43(7):3373-9.
2005: Dori L Borjesson; Scott D Kobayashi; Adeline R Whitney; Jovanka M Voyich; Cynthia M Argue; Frank R DeLeo
Insights into pathogen immune evasion mechanisms: Anaplasma phagocytophilum fails to induce an apoptosis differentiation program in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6364-72.
2005: Stanislava Kocianova; Vuong Cuong; Yufeng Yao; Jovanka M Voyich; Elizabeth R Fischer; Frank R DeLeo; Michael Otto
Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis.
The Journal of clinical investigation 2005;115(3):688-94.
2005: Paul Sumby; Kent D Barbian; Donald J Gardner; Adeline R Whitney; Diane M Welty; R Daniel Long; John R Bailey; Michael J Parnell; Nancy P Hoe; Gerald G Adams; Frank R DeLeo; James M Musser
Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1679-84.
2004: Vuong Cuong; Stanislava Kocianova; Jovanka M Voyich; Yufeng Yao; Elizabeth R Fischer; Frank R DeLeo; Michael Otto
A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence.
The Journal of biological chemistry 2004;279(52):54881-6.
2004: Jovanka M Voyich; James M Musser; Frank R DeLeo
Streptococcus pyogenes and human neutrophils: a paradigm for evasion of innate host defense by bacterial pathogens.
Microbes and infection / Institut Pasteur 2004;6(12):1117-23.
2004: Clayton O Jarrett; Eszter Deak; Karen E Isherwood; Petra C F Oyston; Elizabeth R Fischer; Adeline R Whitney; Scott D Kobayashi; Frank R DeLeo; B Joseph Hinnebusch
Transmission of Yersinia pestis from an infectious biofilm in the flea vector.
The Journal of infectious diseases 2004;190(4):783-92.
2004: David J Banks; Stephen F Porcella; Kent D Barbian; Stephen B Beres; Lauren E Philips; Jovanka M Voyich; Frank R DeLeo; Judith M Martin; Greg Somerville; James M Musser
Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain.
The Journal of infectious diseases 2004;190(4):727-38.
2004: Stephen B Beres; Gail L Sylva; Daniel E Sturdevant; Chanel Granville; Mengyao Liu; Stacy M Ricklefs; Adeline R Whitney; Larye D Parkins; Nancy P Hoe; Gerald J Adams; Donald E Low; Frank R DeLeo; Allison McGeer; James M Musser
Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11833-8.
2004: Jovanka M Voyich; Kevin R Braughton; Daniel E Sturdevant; Vuong Cuong; Scott D Kobayashi; Stephen F Porcella; Michael Otto; James M Musser; Frank R DeLeo
Engagement of the pathogen survival response used by group A Streptococcus to avert destruction by innate host defense.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1194-201.
2004: Frank R DeLeo
Modulation of phagocyte apoptosis by bacterial pathogens.
Apoptosis : an international journal on programmed cell death 2004;9(4):399-413.
2004: S D Kobayashi; Frank R DeLeo
An apoptosis differentiation programme in human polymorphonuclear leucocytes.
Biochemical Society transactions 2004;32(Pt3):474-6.
2004: Vuong Cuong; Jovanka M Voyich; Elizabeth R Fischer; Kevin R Braughton; Adeline R Whitney; Frank R DeLeo; Michael Otto
Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system.
Cellular microbiology 2004;6(3):269-75.
2004: Scott D Kobayashi; Jovanka M Voyich; Kevin R Braughton; Adeline R Whitney; William M Nauseef; Harry L Malech; Frank R DeLeo
Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):636-43.
2003: Sean D Reid; Alison G Montgomery; Jovanka M Voyich; Frank R DeLeo; Benfang Lei; Robin M Ireland; Nicole M Green; Mengyao Liu; Slawomir Lukomski; James M Musser
Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteins.
Infection and immunity 2003;71(12):7043-52.
2003: Scott D Kobayashi; Jovanka M Voyich; Frank R DeLeo
Regulation of the neutrophil-mediated inflammatory response to infection.
Microbes and infection / Institut Pasteur 2003;5(14):1337-44.
2003: Benfang Lei; Mengyao Liu; Jovanka M Voyich; Christopher I Prater; Subbarao V Kala; Frank R DeLeo; James M Musser
Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenes.
Infection and immunity 2003;71(10):5962-9.
2003: Scott D Kobayashi; Kevin R Braughton; Adeline R Whitney; Jovanka M Voyich; Tom G Schwan; James M Musser; Frank R DeLeo
Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10948-53.
2003: Scott D Kobayashi; Jovanka M Voyich; Kevin R Braughton; Frank R DeLeo
Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3357-68.
2003: Jovanka M Voyich; Daniel E Sturdevant; Kevin R Braughton; Scott D Kobayashi; Benfang Lei; Kimmo Virtaneva; David W Dorward; James M Musser; Frank R DeLeo
Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1996-2001.
2003: Scott D Kobayashi; Jovanka M Voyich; Greg Somerville; Kevin R Braughton; Harry L Malech; James M Musser; Frank R DeLeo
An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation.
Journal of leukocyte biology 2003;73(2):315-22.
2003: Scott D Kobayashi; Frank R DeLeo
Apoptosis in human polymorphonuclear leukocytes: searching for a genetic roadmap.
Archivum immunologiae et therapiae experimentalis 2003;51(1):1-8.
2002: Benfang Lei; Frank R DeLeo; Sean D Reid; Jovanka M Voyich; Loranne Magoun; Mengyao Liu; Kevin R Braughton; Stacy M Ricklefs; Nancy P Hoe; Robert L Cole; John M Leong; James M Musser
Opsonophagocytosis-inhibiting mac protein of group a streptococcus: identification and characteristics of two genetic complexes.
Infection and immunity 2002;70(12):6880-90.
2002: Sean D Reid; Nicole M Green; Gail L Sylva; Jovanka M Voyich; Elisha T Stenseth; Frank R DeLeo; Timothy Palzkill; Donald E Low; HARRY HILL; James M Musser
Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response.
Journal of bacteriology 2002;184(22):6316-24.
2002: Benfang Lei; Laura M Smoot; Heather M Menning; Jovanka M Voyich; Subbarao V Kala; Frank R DeLeo; Sean D Reid; James M Musser
Identification and characterization of a novel heme-associated cell surface protein made by Streptococcus pyogenes.
Infection and immunity 2002;70(8):4494-500.
2002: Nancy P Hoe; Robin M Ireland; Frank R DeLeo; Brian B Gowen; David W Dorward; Jovanka M Voyich; Mengyao Liu; Eugene H Burns; Derek M Culnan; Anthony Bretscher; James M Musser
Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7646-51.
2002: Scott D Kobayashi; Jovanka M Voyich; Cassandra L Buhl; Robert M Stahl; Frank R DeLeo
Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6901-6.
2002: Greg Somerville; Stephen B Beres; J Ross Fitzgerald; Frank R DeLeo; Robert L Cole; Jessica S Hoff; James M Musser
In vitro serial passage of Staphylococcus aureus: changes in physiology, virulence factor production, and agr nucleotide sequence.
Journal of bacteriology 2002;184(5):1430-7.
2002: Jovanka M Voyich; Frank R DeLeo
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae.
Methods in cell science : an official journal of the Society for In Vitro Biology 2002;24(1-3):79-90.
2001: Benfang Lei; Frank R DeLeo; Nancy P Hoe; Morag R Graham; SM Mackie; Robert L Cole; Mengyao Liu; HARRY HILL; Donald E Low; Michael J Federle; June R Scott; James M Musser
Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis.
Nature medicine 2001;7(12):1298-305.
2001: Karla J Biberstine-Kinkade; Frank R DeLeo; R I Epstein; B A LeRoy; William M Nauseef; Mary C Dinauer
Heme-ligating histidines in flavocytochrome b(558): identification of specific histidines in gp91(phox).
The Journal of biological chemistry 2001;276(33):31105-12.
2001: James B Burritt; Frank R DeLeo; C L McDonald; Justin R Prigge; Mary C Dinauer; M Nakamura; William M Nauseef; Algirdas J Jesaitis
Phage display epitope mapping of human neutrophil flavocytochrome b558. Identification of two juxtaposed extracellular domains.
The Journal of biological chemistry 2001;276(3):2053-61.
2000: Frank R DeLeo; James B Burritt; L Yu; Algirdas J Jesaitis; M C Dinauer; William M Nauseef
Processing and maturation of flavocytochrome b558 include incorporation of heme as a prerequisite for heterodimer assembly.
The Journal of biological chemistry 2000;275(18):13986-93.
1999: Frank R DeLeo; Lee-Ann H Allen; Michael A Apicella; William M Nauseef
NADPH oxidase activation and assembly during phagocytosis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6732-40.
1999: Frank R DeLeo; Oyebode Olakanmi; George T Rasmussen; Troy S Lewis; SJ McCormick; William M Nauseef; Bradley E Britigan
Despite structural similarities between gp91phox and FRE1, flavocytochrome b558 does not mediate iron uptake by myeloid cells.
The Journal of laboratory and clinical medicine 1999;134(3):275-82.
1999: Lee-Ann H Allen; Frank R DeLeo; A Gallois; S Toyoshima; K Suzuki; William M Nauseef
Transient association of the nicotinamide adenine dinucleotide phosphate oxidase subunits p47phox and p67phox with phagosomes in neutrophils from patients with X-linked chronic granulomatous disease.
Blood 1999;93(10):3521-30.
1999: Lixin Yu; Frank R DeLeo; Karla J Biberstine-Kinkade; J Renee; William M Nauseef; Mary C Dinauer
Biosynthesis of flavocytochrome b558 . gp91(phox) is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum.
The Journal of biological chemistry 1999;274(7):4364-9.
1998: Frank R DeLeo; Melissa Goedken; SJ McCormick; William M Nauseef
A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradation.
The Journal of clinical investigation 1998;101(12):2900-9.
1998: Frank R DeLeo; J Renee; S McCormick; M Nakamura; Michael A Apicella; Jerrold P Weiss; William M Nauseef
Neutrophils exposed to bacterial lipopolysaccharide upregulate NADPH oxidase assembly.
The Journal of clinical investigation 1998;101(2):455-63.
1997: E R Adams; Edward A Dratz; D Gizachew; Frank R DeLeo; L Yu; B D Volpp; M Vlases; Algirdas J Jesaitis; Mark T Quinn
Interaction of human neutrophil flavocytochrome b with cytosolic proteins: transferred-NOESY NMR studies of a gp91phox C-terminal peptide bound to p47phox.
The Biochemical journal 1997;325 ( Pt 1)():249-57.
1996: Frank R DeLeo; Mark T Quinn
Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins.
Journal of leukocyte biology 1996;60(6):677-91.
1996: Frank R DeLeo; Mark A Jutila; Mark T Quinn
Characterization of peptide diffusion into electropermeabilized neutrophils.
Journal of immunological methods 1996;198(1):35-49.
1995: Frank R DeLeo; William M Nauseef; Algirdas J Jesaitis; James B Burritt; Robert Clark; Mark T Quinn
A domain of p47phox that interacts with human neutrophil flavocytochrome b558.
The Journal of biological chemistry 1995;270(44):26246-51.
1995: Frank R DeLeo; L Yu; James B Burritt; L R Loetterle; C W Bond; Algirdas J Jesaitis; Mark T Quinn
Mapping sites of interaction of p47-phox and flavocytochrome b with random-sequence peptide phage display libraries.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):7110-4.