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Neal DeLuca

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Lauren M Wagner; Avraham Bayer; Neal A DeLuca
Requirement of the N-terminal activation domain of herpes simplex virus ICP4 for viral gene expression.
Megan H Orzalli; Neal A DeLuca; David M Knipe
Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.
Lauren M Wagner; Jonathan T Lester; Frances L Sivrich; Neal A DeLuca
The N terminus and C terminus of herpes simplex virus 1 ICP4 cooperate to activate viral gene expression.

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All Publications

2013: Lauren M Wagner; Avraham Bayer; Neal A DeLuca
Requirement of the N-terminal activation domain of herpes simplex virus ICP4 for viral gene expression.
Journal of virology 2013;87(2):1010-8.
2012: Megan H Orzalli; Neal A DeLuca; David M Knipe
Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(44):E3008-17.
2012: Lauren M Wagner; Jonathan T Lester; Frances L Sivrich; Neal A DeLuca
The N terminus and C terminus of herpes simplex virus 1 ICP4 cooperate to activate viral gene expression.
Journal of virology 2012;86(12):6862-74.
2011: Jonathan T Lester; Neal A DeLuca
Herpes simplex virus 1 ICP4 forms complexes with TFIID and mediator in virus-infected cells.
Journal of virology 2011;85(12):5733-44.
2011: Michael W Ferenczy; Daniel J Ranayhossaini; Neal A DeLuca
Activities of ICP0 involved in the reversal of silencing of quiescent herpes simplex virus 1.
Journal of virology 2011;85(10):4993-5002.
2011: Michael W Ferenczy; Neal A DeLuca
Reversal of heterochromatic silencing of quiescent herpes simplex virus type 1 by ICP0.
Journal of virology 2011;85(7):3424-35.
2009: Michael W Ferenczy; Neal A DeLuca
Epigenetic modulation of gene expression from quiescent herpes simplex virus genomes.
Journal of virology 2009;83(17):8514-24.
2009: Xueqiao Liu; Eeva Broberg; Daisuke Watanabe; Timothy Dudek; Neal A DeLuca; David M Knipe
Genetic engineering of a modified herpes simplex virus 1 vaccine vector.
Vaccine 2009;27(21):2760-7.
2008: Costas G Hadjipanayis; Wendy Fellows-Mayle; Neal A DeLuca
Therapeutic efficacy of a herpes simplex virus with radiation or temozolomide for intracranial glioblastoma after convection-enhanced delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(11):1783-8.
2008: Susan E Zabierowski; Neal A DeLuca
Stabilized binding of TBP to the TATA box of herpes simplex virus type 1 early (tk) and late (gC) promoters by TFIIA and ICP4.
Journal of virology 2008;82(7):3546-54.
2008: Padmavathi Sampath; Neal A DeLuca
Binding of ICP4, TATA-binding protein, and RNA polymerase II to herpes simplex virus type 1 immediate-early, early, and late promoters in virus-infected cells.
Journal of virology 2008;82(5):2339-49.
2007: Tracy Terry-Allison; Colton A Smith; Neal A DeLuca
Relaxed repression of herpes simplex virus type 1 genomes in Murine trigeminal neurons.
Journal of virology 2007;81(22):12394-405.
2007: Ruhul H Kuddus; Neal A DeLuca
DNA-dependent oligomerization of herpes simplex virus type 1 regulatory protein ICP4.
Journal of virology 2007;81(17):9230-7.
2005: Constantinos G Hadjipanayis; Neal A DeLuca
Inhibition of DNA repair by a herpes simplex virus vector enhances the radiosensitivity of human glioblastoma cells.
Cancer research 2005;65(12):5310-6.
2004: Darren Wolfe; A Niranjan; Anita M Trichel; Clayton A Wiley; Ali Ozuer; Emanuel Kanal; D Kondziolka; David M Krisky; James Goss; Neal A DeLuca; Michael Murphey-Corb; Joseph C Glorioso
Safety and biodistribution studies of an HSV multigene vector following intracranial delivery to non-human primates.
Gene therapy 2004;11(23):1675-84.
2004: Susan Zabierowski; Neal A DeLuca
Differential cellular requirements for activation of herpes simplex virus type 1 early (tk) and late (gC) promoters by ICP4.
Journal of virology 2004;78(12):6162-70.
2003: Ajay Niranjan; Darren Wolfe; Masakazu Tamura; M Karina Soares; David M Krisky; L Dade Lunsford; Songhui Li; Wendy Fellows-Mayle; Neal A DeLuca; Justus B Cohen; Joseph C Glorioso
Treatment of rat gliosarcoma brain tumors by HSV-based multigene therapy combined with radiosurgery.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(4):530-42.
2003: Sara A Jackson; Neal A DeLuca
Relationship of herpes simplex virus genome configuration to productive and persistent infections.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7871-6.
2003: Peter Compel; Neal A DeLuca
Temperature-dependent conformational changes in herpes simplex virus ICP4 that affect transcription activation.
Journal of virology 2003;77(5):3257-68.
2002: Dool-Bboon Kim; Neal A DeLuca
Phosphorylation of transcription factor Sp1 during herpes simplex virus type 1 infection.
Journal of virology 2002;76(13):6473-9.
2002: Kasey M Eidson; William E Hobbs; Brian J Manning; Paul Carlson; Neal A DeLuca
Expression of herpes simplex virus ICP0 inhibits the induction of interferon-stimulated genes by viral infection.
Journal of virology 2002;76(5):2180-91.
2002: Dool-Bboon Kim; Susan Zabierowski; Neal A DeLuca
The initiator element in a herpes simplex virus type 1 late-gene promoter enhances activation by ICP4, resulting in abundant late-gene expression.
Journal of virology 2002;76(4):1548-58.
2001: William E Hobbs; D E Brough; Imre Kovesdi; Neal A DeLuca
Efficient activation of viral genomes by levels of herpes simplex virus ICP0 insufficient to affect cellular gene expression or cell survival.
Journal of virology 2001;75(7):3391-403.
2000: B Grondin; Neal A DeLuca
Herpes simplex virus type 1 ICP4 promotes transcription preinitiation complex formation by enhancing the binding of TFIID to DNA.
Journal of virology 2000;74(24):11504-10.
2000: David J Fink; Neal A DeLuca; M Yamada; Darren P Wolfe; Joseph C Glorioso
Design and application of HSV vectors for neuroprotection.
Gene therapy 2000;7(2):115-9.
1999: William E Hobbs; Neal A DeLuca
Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0.
Journal of virology 1999;73(10):8245-55.
1999: MA Brehm; LA Samaniego; Robert H Bonneau; Neal A DeLuca; Satvir S Tevethia
Immunogenicity of herpes simplex virus type 1 mutants containing deletions in one or more alpha-genes: ICP4, ICP27, ICP22, and ICP0.
Virology 1999;256(2):258-69.
1998: P A Bates; Neal A DeLuca
The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia.
Journal of virology 1998;72(9):7115-24.
1998: Michael J Carrozza; Neal A DeLuca
The high mobility group protein 1 is a coactivator of herpes simplex virus ICP4 in vitro.
Journal of virology 1998;72(8):6752-7.
1998: LA Samaniego; L Neiderhiser; Neal A DeLuca
Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins.
Journal of virology 1998;72(4):3307-20.
1997: LA Samaniego; N Wu; Neal A DeLuca
The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27.
Journal of virology 1997;71(6):4614-25.
1996: N Wu; simon simon watkins; P A Schaffer; Neal A DeLuca
Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22.
Journal of virology 1996;70(9):6358-69.
1996: Z Zhu; Neal A DeLuca; Priscilla A Schaffer
Overexpression of the herpes simplex virus type 1 immediate-early regulatory protein, ICP27, is responsible for the aberrant localization of ICP0 and mutant forms of ICP4 in ICP4 mutant virus-infected cells.
Journal of virology 1996;70(8):5346-56.
1996: Michael J Carrozza; Neal A DeLuca
Interaction of the viral activator protein ICP4 with TFIID through TAF250.
Molecular and cellular biology 1996;16(6):3085-93.
1996: K Xia; Neal A DeLuca; David M Knipe
Analysis of phosphorylation sites of herpes simplex virus type 1 ICP4.
Journal of virology 1996;70(2):1061-71.
1996: K Xia; David M Knipe; Neal A DeLuca
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication.
Journal of virology 1996;70(2):1050-60.
1996: David J Fink; Neal A DeLuca; William F Goins; Joseph C Glorioso
Gene transfer to neurons using herpes simplex virus-based vectors.
Annual review of neuroscience 1996;19():265-87.
1995: W James Cook; S M Lin; Neal A DeLuca; Donald M Coen
Initiator elements and regulated expression of the herpes simplex virus thymidine kinase gene.
Journal of virology 1995;69(11):7291-4.
1995: W James Cook; B Gu; Neal A DeLuca; E B Moynihan; Donald M Coen
Induction of transcription by a viral regulatory protein depends on the relative strengths of functional TATA boxes.
Molecular and cellular biology 1995;15(9):4998-5006.
1995: L A Samaniego; A L Webb; Neal A DeLuca
Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4.
Journal of virology 1995;69(9):5705-15.
1995: Ruhul H Kuddus; B Gu; Neal A DeLuca
Relationship between TATA-binding protein and herpes simplex virus type 1 ICP4 DNA-binding sites in complex formation and repression of transcription.
Journal of virology 1995;69(9):5568-75.
1995: Joseph C Glorioso; M A Bender; William F Goins; David J Fink; Neal A DeLuca
HSV as a gene transfer vector for the nervous system.
Molecular biotechnology 1995;4(1):87-99.
1995: B Gu; Ruhul H Kuddus; Neal A DeLuca
Repression of activator-mediated transcription by herpes simplex virus ICP4 via a mechanism involving interactions with the basal transcription factors TATA-binding protein and TFIIB.
Molecular and cellular biology 1995;15(7):3618-26.
1995: Joseph C Glorioso; M A Bender; David J Fink; Neal A DeLuca
Herpes simplex virus vectors.
Molecular and cell biology of human diseases series 1995;5():33-63.
1995: Joseph C Glorioso; Neal A DeLuca; David J Fink
Development and application of herpes simplex virus vectors for human gene therapy.
Annual review of microbiology 1995;49():675-710.
1994: B Gu; Neal A DeLuca
Requirements for activation of the herpes simplex virus glycoprotein C promoter in vitro by the viral regulatory protein ICP4.
Journal of virology 1994;68(12):7953-65.
1994: R Rivera-Gonzalez; A N Imbalzano; B Gu; Neal A DeLuca
The role of ICP4 repressor activity in temporal expression of the IE-3 and latency-associated transcript promoters during HSV-1 infection.
Virology 1994;202(2):550-64.
1994: Joseph C Glorioso; William F Goins; Neal A DeLuca; David J Fink
Development of herpes simplex virus as a gene transfer vector for the nervous system.
Gene therapy 1994;1 Suppl 1():S39.
1994: Joseph C Glorioso; William F Goins; C A Meaney; David J Fink; Neal A DeLuca
Gene transfer to brain using herpes simplex virus vectors.
Annals of neurology 1994;35 Suppl():S28-34.
1994: Joseph C Glorioso; William F Goins; David J Fink; Neal A DeLuca
Herpes simplex virus vectors and gene transfer to brain.
Developments in biological standardization 1994;82():79-87.
1993: B Gu; R Rivera-Gonzalez; C A Smith; Neal A DeLuca
Herpes simplex virus infected cell polypeptide 4 preferentially represses Sp1-activated over basal transcription from its own promoter.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9528-32.
1993: C A Smith; P Bates; R Rivera-Gonzalez; B Gu; Neal A DeLuca
ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB.
Journal of virology 1993;67(8):4676-87.
1993: Prashant Desai; Neal A DeLuca; Joseph C Glorioso; Stanley Person
Mutations in herpes simplex virus type 1 genes encoding VP5 and VP23 abrogate capsid formation and cleavage of replicated DNA.
Journal of virology 1993;67(3):1357-64.
1992: C A Smith; Neal A DeLuca
Transdominant inhibition of herpes simplex virus growth in transgenic mice.
Virology 1992;191(2):581-8.
1992: A N Imbalzano; Neal A DeLuca
Substitution of a TATA box from a herpes simplex virus late gene in the viral thymidine kinase promoter alters ICP4 inducibility but not temporal expression.
Journal of virology 1992;66(9):5453-63.
1991: A A Shepard; Neal A DeLuca
A second-site revertant of a defective herpes simplex virus ICP4 protein with restored regulatory activities and impaired DNA-binding properties.
Journal of virology 1991;65(2):787-95.
1991: A N Imbalzano; Donald M Coen; Neal A DeLuca
Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
Journal of virology 1991;65(2):565-74.
1991: A A Shepard; Neal A DeLuca
Activities of heterodimers composed of DNA-binding- and transactivation-deficient subunits of the herpes simplex virus regulatory protein ICP4.
Journal of virology 1991;65(1):299-307.
1990: E Antonio Chiocca; B B Choi; W Z Cai; Neal A DeLuca; Priscilla A Schaffer; Marian DiFiglia; Xandra O Breakefield; R L Martuza
Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants.
The New biologist 1990;2(8):739-46.
1990: A A Shepard; P Tolentino; Neal A DeLuca
trans-dominant inhibition of herpes simplex virus transcriptional regulatory protein ICP4 by heterodimer formation.
Journal of virology 1990;64(8):3916-26.
1990: A N Imbalzano; A A Shepard; Neal A DeLuca
Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene.
Journal of virology 1990;64(6):2620-31.
1989: A A Shepard; A N Imbalzano; Neal A DeLuca
Separation of primary structural components conferring autoregulation, transactivation, and DNA-binding properties to the herpes simplex virus transcriptional regulatory protein ICP4.
Journal of virology 1989;63(9):3714-28.
1989: A A Shepard; Neal A DeLuca
Intragenic complementation among partial peptides of herpes simplex virus regulatory protein ICP4.
Journal of virology 1989;63(3):1203-11.
1988: Neal A DeLuca; Priscilla A Schaffer
Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4.
Journal of virology 1988;62(3):732-43.
1987: W Z Cai; Stanley Person; S C Warner; J H Zhou; Neal A DeLuca
Linker-insertion nonsense and restriction-site deletion mutations of the gB glycoprotein gene of herpes simplex virus type 1.
Journal of virology 1987;61(3):714-21.
1984: Neal A DeLuca; Stanley Person; David J Bzik; W Snipes
Genome locations of temperature-sensitive mutants in glycoprotein gB of herpes simplex virus type 1.
Virology 1984;137(2):382-9.
1984: David J Bzik; Barbara A Fox; Neal A DeLuca; Stanley Person
Nucleotide sequence of a region of the herpes simplex virus type 1 gB glycoprotein gene: mutations affecting rate of virus entry and cell fusion.
Virology 1984;137(1):185-90.
1984: David J Bzik; Barbara A Fox; Neal A DeLuca; Stanley Person
Nucleotide sequence specifying the glycoprotein gene, gB, of herpes simplex virus type 1.
Virology 1984;133(2):301-14.
1983: K G Kousoulas; David J Bzik; Neal A DeLuca; Stanley Person
The effect of ammonium chloride and tunicamycin on the glycoprotein content and infectivity of herpes simplex virus type 1.
Virology 1983;125(2):468-74.
1982: Neal A DeLuca; David J Bzik; Vincent Craig Bond; Stanley Person; W Snipes
Nucleotide sequences of herpes simplex virus type 1 (HSV-1) affecting virus entry, cell fusion, and production of glycoprotein gb (VP7).
Virology 1982;122(2):411-23.
1981: Neal A DeLuca; David J Bzik; Stanley Person; W Snipes
Early events in herpes simplex virus type 1 infection: photosensitivity of fluorescein isothiocyanate-treated virions.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(2):912-6.
1980: W D Taylor; Neal A DeLuca; K Vollherbst; T Doman; T d'Amato; W Snipes
Characteristics of a new bacteriophage, Psp231a, infecting Pseudomonas phaseolicola HB10Y.
Journal of virology 1980;35(3):918-23.
1980: Neal A DeLuca; A Keith; W Snipes
Studies with a hydrophobic, spin-labeled virucidal agent.
Antimicrobial agents and chemotherapy 1980;17(1):63-70.