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George Demetri

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Antoine Hollebecque; Sophie Postel-Vinay; Philippe Bedard; George D Demetri; Keith Flaherty; Jaap Verweij; Jean-Charles Soria
Modifying phase I methodology to facilitate enrolment of molecularly selected patients.
George D Demetri; Hans Gelderblom; Peter Hohenberger; Heikki Joensuu; Yoon-Koo Kang; Christian Kappeler; Iris Kuss; Dirk Laurent; Axel Le Cesne; Michael Leahy; ROBERT G MAKI; Binh Bui Nguyen; Toshirou Nishida; Peter Reichardt; Piotr Rutkowski; Patrick Schöffski; Margaret von Mehren; Jianming Xu; Giuseppe Badalamenti; Sebastian Bauer; Martin E Blackstein; Jean-Yves Blay; Paolo G Casali; John Chung
Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial.
S George; T Lechner; Sigui Li; P Reichardt; D P Cohen; George D Demetri
Hypertension as a potential biomarker of efficacy in patients with gastrointestinal stromal tumor treated with sunitinib.

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2013: Antoine Hollebecque; Sophie Postel-Vinay; Philippe Bedard; George D Demetri; Keith Flaherty; Jaap Verweij; Jean-Charles Soria
Modifying phase I methodology to facilitate enrolment of molecularly selected patients.
European journal of cancer (Oxford, England : 1990) 2013;49(7):1515-20.
2013: George D Demetri; Hans Gelderblom; Peter Hohenberger; Heikki Joensuu; Yoon-Koo Kang; Christian Kappeler; Iris Kuss; Dirk Laurent; Axel Le Cesne; Michael Leahy; ROBERT G MAKI; Binh Bui Nguyen; Toshirou Nishida; Peter Reichardt; Piotr Rutkowski; Patrick Schöffski; Margaret von Mehren; Jianming Xu; Giuseppe Badalamenti; Sebastian Bauer; Martin E Blackstein; Jean-Yves Blay; Paolo G Casali; John Chung
Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial.
Lancet 2013;381(9863):295-302.
2012: S George; T Lechner; Sigui Li; P Reichardt; D P Cohen; George D Demetri
Hypertension as a potential biomarker of efficacy in patients with gastrointestinal stromal tumor treated with sunitinib.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2012;23(12):3180-7.
2012: Andrew J Wagner; Feng Chai; Edwin Choy; Ian Davis; Steven G Dubois; James Geller; John M Goldberg; David Hogg; Ian Judson; Alberto Pappo; Lee Rosen; Brian Schwartz; Neil Senzer; Carol Waghorne; George D Demetri
Tivantinib (ARQ 197), a selective inhibitor of MET, in patients with microphthalmia transcription factor-associated tumors: results of a multicenter phase 2 trial.
Cancer 2012;118(23):5894-902.
2012: Axel Le Cesne; Vicente Alfaro; Carme Balaña; Jean Yves Blay; Paolo G Casali; Sara Cresta; Federica Grosso; Pilar Lardelli; ROBERT G MAKI; Antonio Nieto; Andrés Poveda; Patrick Schöffski; Jaap Verweij; George D Demetri
A retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas.
European journal of cancer (Oxford, England : 1990) 2012;48(16):3036-44.
2012: Michael J Pishvaian; Andrew J Wagner; Hamim Zahir; Robert A Beckman; Catherine Copigneaux; Ion Cotarla; Hirut Daniel; John F Deeken; Abdel-Baset Halim; A Ruth He; Jimmy J Hwang; Kejian Liu; Shakun Malik; John L Marshall; George D Demetri
A phase 1 study of efatutazone, an oral peroxisome proliferator-activated receptor gamma agonist, administered to patients with advanced malignancies.
Cancer 2012;118(21):5403-13.
2012: Nilka de Jesus-Gonzalez; George D Demetri; Suzanne George; Michael C Heinrich; Radostin Penchev; Emily Robinson; William Tap; Margaret von Mehren; Qian Wang; Benjamin D Humphreys
Regorafenib induces rapid and reversible changes in plasma nitric oxide and endothelin-1.
American journal of hypertension 2012;25(10):1118-23.
2012: Martin D McCarter; David M Ota; Peter W T Pisters; Margaret von Mehren; Cristina R Antonescu; Karla V Ballman; Charles D Blanke; Murray F Brennan; Ronald P DeMatteo; George D Demetri; ROBERT G MAKI; Linda McCall
Microscopically positive margins for primary gastrointestinal stromal tumors: analysis of risk factors and tumor recurrence.
Journal of the American College of Surgeons 2012;215(1):53-9; discussion 59-60.
2012: Suzanne George; Michael C Heinrich; Judith Manola; Jeffrey A Morgan; Sarah M Solomon; William D Tap; Annick D Van den Abbeele; Margaret von Mehren; Andrew J Wagner; Qian Wang; Jeffrey T Yap; Meijun Zhu; James E Butrynski; Edwin Choy; Christopher L Corless; Jonathan A Fletcher; George D Demetri
Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(19):2401-7.
2012: Anupma Jati; Jeffrey A Morgan; George D Demetri; Jonathan N Glickman; Servet Tatlı; Annick Van den Abbele; Stuart G Silverman
Imaging features of bone metastases in patients with gastrointestinal stromal tumors.
Diagnostic and interventional radiology (Ankara, Turkey) 2012;18(4):391-6.
2012: George D Demetri; Christopher R Garrett; David Goldstein; Charles S Harmon; Xin Huang; Herbert I Hurwitz; Axel Le Cesne; Serge Leyvraz; Grant A McArthur; Luis Paz-Ares; Antonio Lopez Pousa; Patrick Schöffski; Manisha H Shah; Vanessa Tassell; Jaap Verweij; Qiang Casey Xu; Jean-Yves Blay; Darrel P Cohen; Paolo G Casali
Complete longitudinal analyses of the randomized, placebo-controlled, phase III trial of sunitinib in patients with gastrointestinal stromal tumor following imatinib failure.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(11):3170-9.
2012: Axel Le Cesne; ROBERT G MAKI; Jean-Louis Misset; Antonio Nieto; Alejandro Yovine; Jean-Yves Blay; Suzette Delaloge; Pilar Frontelo; Juhui James Jiao; George D Demetri
A retrospective pooled analysis of trabectedin safety in 1,132 patients with solid tumors treated in phase II clinical trials.
Investigational new drugs 2012;30(3):1193-202.
2012: William D Tap; Richard Tozer; Min Zhu; Sunita Badola; Phillip Barnette; Pasquale Benedetto; Sung Chang; George D Demetri; Hongjie Deng; Jayesh Desai; Gregory Friberg; Petr Kavan; Ian Leitch; Ian McCaffery; Anthony Tolcher
Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(15):1849-56.
2012: Winette T A van der Graaf; Massimo Aglietta; Nobuhito Araki; Yasuo Beppu; Jean-Yves Blay; Binh Bui-Nguyen; Paolo G Casali; Sant P Chawla; Corneel Coens; Angelo Paolo Dei Tos; George D Demetri; Mohammed R Dewji; Christopher D Fletcher; Hans Gelderblom; Rachel Hodge; Peter Hohenberger; Ian R Judson; Dong-Wan Kim; Axel Le Cesne; Sandrine Marreaud; Monia Ouali; Patrick Schöffski; Arthur P Staddon
Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial.
Lancet 2012;379(9829):1879-86.
2012: Dian Wang; James C Watson; Qiang Zhang; Charles D Blanke; George D Demetri; Michael C Heinrich; John P Hoffman; John M Kane; Scott Okuno; Margaret von Mehren; Burton L Eisenberg
Phase II trial of neoadjuvant/adjuvant imatinib mesylate for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumors: long-term follow-up results of Radiation Therapy Oncology Group 0132.
Annals of surgical oncology 2012;19(4):1074-80.
2012: George D Demetri; Yong-jiang Hei; Axel Le Cesne; ROBERT G MAKI; Dominic P Smethurst; Bruce A Bach; Sarah Bray; Thomas Brodowicz; Sant P Chawla; Jean-Yves Blay
First-line treatment of metastatic or locally advanced unresectable soft tissue sarcomas with conatumumab in combination with doxorubicin or doxorubicin alone: a phase I/II open-label and double-blind study.
European journal of cancer (Oxford, England : 1990) 2012;48(4):547-63.
2012: Alessandro Gronchi; P Hohenberger; R J Hohl; P Lardelli; Axel Le Cesne; A Nieto; I Pérez; Silvana Pilotti; Elena Tamborini; Juan C Tercero; Sylvie Bonvalot; B N Bui; George D Demetri; Stefano Ferrari; V Alfaro; Jean-Yves Blay
Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2012;23(3):771-6.
2012: Margaret von Mehren; Vivien Bramwell; George D Demetri; John R Goldblum; Cathryn Rankin; Christopher W Ryan; Ernest Borden
Phase 2 Southwest Oncology Group-directed intergroup trial (S0505) of sorafenib in advanced soft tissue sarcomas.
Cancer 2012;118(3):770-6.
2012: Chandrajit P Raut; Johanna Lahdenranta; Jeffrey A Morgan; Richard Quek; Marek Ancukiewicz; Yves Boucher; George D Demetri; Dan G Duda; J Paul Eder; Rakesh K Jain
Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948).
PloS one 2012;7(2):e26331.
2011: Alejandro Gutierrez; Elena Kozakewich; George D Demetri; Christopher D M Fletcher; Jonathan A Fletcher; Ruta Grebliunaite; Adrian Marino-Enriquez; Wen-Bin Ou; Antonio R Perez-Atayde; Chandrajit P Raut; Ewa Sicinska; Stefano Sioletic; Eric L Snyder; Andrew J Wagner; Yi-Xiang Zhang; A Thomas Look
Aberrant AKT activation drives well-differentiated liposarcoma.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(39):16386-91.
2011: George D Demetri
Differential properties of current tyrosine kinase inhibitors in gastrointestinal stromal tumors.
Seminars in oncology 2011;38 Suppl 1():S10-9.
2011: Jean-Yves Blay; George D Demetri
The evolution of a revolutionary class: extending benefits of tyrosine kinase inhibitors--introduction.
Seminars in oncology 2011;38 Suppl 1():S1-2.
2011: Richard Quek; Qian Wang; Jeffrey A Morgan; Geoffrey I Shapiro; James E Butrynski; Nikhil Ramaiya; Tarsha Huftalen; Nicole Jederlinic; Judith Manola; Andrew J Wagner; George D Demetri; Suzanne George
Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(4):871-9.
2011: George D Demetri
mTOR inhibitors in sarcoma.
Clinical advances in hematology & oncology : H&O 2011;9(2):145-7.
2011: Katherine Anne Janeway; Su Young Kim; Maya Lodish; Vânia Nosé; Pierre Rustin; José Gaal; Patricia Dahia; Bernadette Liegl; Evan R Ball; Margarita Raygada; Angela H Lai; Lorna Kelly; Jason L Hornick; Maureen O'Sullivan; Ronald R de Krijger; Winand N M Dinjens; George D Demetri; Cristina R Antonescu; Jonathan A Fletcher; Lee Helman; Constantine A Stratakis
Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):314-8.
2010: Takaaki Sasaki; Katsuhiro Okuda; Wei Zheng; James E Butrynski; Marzia Capelletti; Liping Wang; Nathanael S Gray; Keith Wilner; James G Christensen; George D Demetri; Geoffrey I Shapiro; Scott J Rodig; Michael J Eck; Pasi A Janne
The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers.
Cancer research 2010;70(24):10038-43.
2010: Katherine Anne Janeway; Mei-Jun Zhu; Jordi Barretina; Antonio Perez-Atayde; George D Demetri; Jonathan A Fletcher
Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification.
International journal of cancer. Journal international du cancer 2010;127(11):2718-22.
2010: James E Butrynski; David R D'Adamo; Jason L Hornick; Paola Dal Cin; Cristina R Antonescu; Suresh C Jhanwar; Marc Ladanyi; Marzia Capelletti; Scott J Rodig; Nikhil H Ramaiya; Eunice L Kwak; Jeffrey W Clark; Keith D Wilner; James G Christensen; Pasi A Janne; ROBERT G MAKI; George D Demetri; Geoffrey I Shapiro
Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.
The New England journal of medicine 2010;363(18):1727-33.
2010: George D Demetri
Disease state awareness in sarcoma.
Clinical advances in hematology & oncology : H&O 2010;8(8):543-5.
2010: Brett E Houk; Carlo L Bello; Bill Poland; Lee S Rosen; George D Demetri; Robert J Motzer
Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis.
Cancer chemotherapy and pharmacology 2010;66(2):357-71.
2010: George D Demetri; Scott Antonia; Robert S Benjamin; Marilyn M Bui; Ephraim S Casper; Ernest U Conrad; Thomas F DeLaney; Kristen N Ganjoo; Martin J Heslin; Raymond J Hutchinson; John M Kane; G Douglas Letson; Sean V McGarry; Richard J O'Donnell; I Benjamin Paz; John D Pfeifer; Raphael E Pollock; R Lor Randall; Richard F Riedel; Karen D Schupak; Herbert S Schwartz; KATHERINE THORNTON; Margaret von Mehren; Jeffrey Wayne
Soft tissue sarcoma.
Journal of the National Comprehensive Cancer Network : JNCCN 2010;8(6):630-74.
2010: George D Demetri; Margaret von Mehren; Cristina R Antonescu; Ronald P DeMatteo; Kristen N Ganjoo; ROBERT G MAKI; Peter W T Pisters; Chandrajit P Raut; Richard F Riedel; Scott M Schuetze; Hema M Sundar; Jonathan Trent; Jeffrey D Wayne
NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.
Journal of the National Comprehensive Cancer Network : JNCCN 2010;8 Suppl 2():S1-41; quiz S42-4.
2010: Andrew J Wagner; Izabela Malinowska Kolodziej; Jeffrey A Morgan; Wei Qin; Christopher D M Fletcher; Natalie Vena; Azra H Ligon; Cristina R Antonescu; Nikhil H Ramaiya; George D Demetri; David J Kwiatkowski; ROBERT G MAKI
Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(5):835-40.
2010: Brian P Rubin; Charles D Blanke; George D Demetri; Ronald P DeMatteo; Christopher D M Fletcher; John R Goldblum; Jerzy Lasota; Alexander Lazar; ROBERT G MAKI; Markku Miettinen; Amy Noffsinger; Mary Kay Washington; Thomas Krausz
Protocol for the examination of specimens from patients with gastrointestinal stromal tumor.
Archives of pathology & laboratory medicine 2010;134(2):165-70.
2010: Chandrajit P Raut; Qian Wang; Judith Manola; Jeffrey A Morgan; Suzanne George; Andrew J Wagner; James E Butrynski; Christopher D M Fletcher; George D Demetri; Monica M Bertagnolli
Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumor treated with sunitinib malate.
Annals of surgical oncology 2010;17(2):407-15.
2009: Todd A Theman; Tristan L Hartzell; Indranil Sinha; Kathleen Polson; Jeffrey Morgan; George D Demetri; Dennis P Orgill; Suzanne George
Recognition of a new chemotherapeutic vesicant: trabectedin (ecteinascidin-743) extravasation with skin and soft tissue damage.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(33):e198-200.
2009: Kristen N Ganjoo; George D Demetri; Charlotte Jacobs; Shreyaskumar Patel
Acute myeloid leukemia in patients with gastrointestinal stromal tumors treated with Gleevec.
Leukemia & lymphoma 2009;50(11):1882-4.
2009: Chandrajit P Raut; Marisa R Nucci; Qian Wang; Judith Manola; Monica M Bertagnolli; George D Demetri; Jeffrey A Morgan; Michael G Muto; Christopher D M Fletcher; Suzanne George
Predictive value of FIGO and AJCC staging systems in patients with uterine leiomyosarcoma.
European journal of cancer (Oxford, England : 1990) 2009;45(16):2818-24.
2009: George D Demetri; Patricia M LoRusso; Iain R J MacPherson; Ding Wang; Jeffrey A Morgan; Valerie G Brunton; Prashni Paliwal; Shruti Agrawal; Maurizio Voi; T R J Evans
Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):6232-40.
2009: Samuel E DePrimo; Xin Huang; Martin E Blackstein; Christopher R Garrett; Charles S Harmon; Patrick Schöffski; Manisha H Shah; Jaap Verweij; Charles M Baum; George D Demetri
Circulating levels of soluble KIT serve as a biomarker for clinical outcome in gastrointestinal stromal tumor patients receiving sunitinib following imatinib failure.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(18):5869-77.
2009: George D Demetri; Michael C Heinrich; Jonathan A Fletcher; Christopher D M Fletcher; Annick D Van den Abbeele; Christopher L Corless; Cristina R Antonescu; Suzanne George; Jeffrey A Morgan; Ming Hui Chen; Carlo L Bello; Xin Huang; Darrel P Cohen; Charles M Baum; ROBERT G MAKI
Molecular target modulation, imaging, and clinical evaluation of gastrointestinal stromal tumor patients treated with sunitinib malate after imatinib failure.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(18):5902-9.
2009: George D Demetri; Paolo G Casali; Jean-Yves Blay; Margaret von Mehren; Jeffrey A Morgan; Rossella Bertulli; ISABELLE RAY COQUARD; Philippe Cassier; Monica Davey; Hossein Borghaei; Daniel Pink; Maria Debiec-Rychter; Wing Cheung; Stuart M Bailey; Maria Luisa Veronese; Annette Reichardt; Elena Fumagalli; Peter Reichardt
A phase I study of single-agent nilotinib or in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(18):5910-6.
2009: George D Demetri; Sant P Chawla; Margaret von Mehren; Paul Ritch; Laurence H Baker; Jean Y Blay; Kenneth R Hande; Mary-Louise Keohan; Brian L Samuels; Scott M Schuetze; Claudia Lebedinsky; Yusri A Elsayed; Miguel A Izquierdo; Javier Gómez; Youn C Park; Axel Le Cesne
Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(25):4188-96.
2009: Robert S Benjamin; Maria Debiec-Rychter; Axel Le Cesne; Stefan Sleijfer; George D Demetri; Heikki Joensuu; Patrick Schöffski; Andrés Poveda
Gastrointestinal stromal tumors II: medical oncology and tumor response assessment.
Seminars in oncology 2009;36(4):302-11.
2009: George D Demetri; Yanfeng Wang; Elisabeth Wehrle; Amy Racine; Zariana Nikolova; Charles D Blanke; Heikki Joensuu; Margaret von Mehren
Imatinib plasma levels are correlated with clinical benefit in patients with unresectable/metastatic gastrointestinal stromal tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(19):3141-7.
2009: Suzanne George; Priscilla Merriam; ROBERT G MAKI; Annick D Van den Abbeele; Jeffrey T Yap; Timothy Akhurst; David C Harmon; Gauri Bhuchar; Margaret M O'Mara; David R D'Adamo; Jeffrey Morgan; Gary K Schwartz; Andrew J Wagner; James E Butrynski; George D Demetri; Mary-Louise Keohan
Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(19):3154-60.
2009: Katherine Anne Janeway; Karen H Albritton; Annick D Van den Abbeele; Gina Z D'Amato; Paolo Pedrazzoli; Salvatore Siena; Joel Picus; James E Butrynski; Marcus Schlemmer; Michael C Heinrich; George D Demetri
Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib.
Pediatric blood & cancer 2009;52(7):767-71.
2009: Suzanne George; J Y Blay; P G Casali; A Le Cesne; P Stephenson; Samuel E DePrimo; C S Harmon; C N J Law; Jeffrey A Morgan; ISABELLE RAY COQUARD; V Tassell; D P Cohen; George D Demetri
Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure.
European journal of cancer (Oxford, England : 1990) 2009;45(11):1959-68.
2009: Ronald P DeMatteo; Karla V Ballman; Cristina R Antonescu; ROBERT G MAKI; Peter W T Pisters; George D Demetri; Martin E Blackstein; Charles D Blanke; Margaret von Mehren; Murray F Brennan; Shreyaskumar Patel; Martin D Mccarter; Jonathan A Polikoff; Benjamin R Tan; Kouros Owzar
Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial.
Lancet 2009;373(9669):1097-104.
2009: Ketan S Gajiwala; Joe C Wu; James Christensen; Gayatri D Deshmukh; Wade Diehl; Jonathan P DiNitto; Jessie M English; Michael J Greig; You Ai He; Suzanne L Jacques; Elizabeth A Lunney; Michele McTigue; David Molina; Terri Quenzer; Peter A Wells; Xiu Yu; Yan Zhang; Aihua Zou; Mark R Emmett; Alan G Marshall; Hui-Min Zhang; George D Demetri
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1542-7.
2009: George D Demetri
Therapeutic monitoring of drug plasma concentrations and improved clinical outcomes in GIST.
Clinical advances in hematology & oncology : H&O 2009;7(2):S6-7.
2009: Richard Quek; Jeffrey A Morgan; Suzanne George; James E Butrynski; Kathleen Polson; Fremonta Meyer; George D Demetri; Susan D Block
Small molecule tyrosine kinase inhibitor and depression.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(2):312-3.
2009: Jeffrey Crawford; James Armitage; Lodovico Balducci; Charles L Bennett; Douglas W Blayney; Spero R Cataland; David C Dale; George D Demetri; Harry P Erba; James Foran; Alison G Freifeld; Marti Goemann; Mark L Heaney; Sally Htoy; Susan Hudock; Dwight D Kloth; David J Kuter; Gary H Lyman; Laura Boehnke Michaud; Sarah C Miyata; Martin S Tallman; Saroj Vadhan-Raj; Peter Westervelt; Michael K Wong
Myeloid growth factors.
Journal of the National Comprehensive Cancer Network : JNCCN 2009;7(1):64-83.
2008: Xiaofeng Jiang; Jun Zhou; Noah K Yuen; Christopher L Corless; Michael C Heinrich; Jonathan A Fletcher; George D Demetri; Hans R Widlund; David E Fisher; F Stephen Hodi
Imatinib targeting of KIT-mutant oncoprotein in melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7726-32.
2008: Laurence H Baker; Eric K Rowinsky; David Mendelson; Rod A Humerickhouse; Raymond A Knight; Jiang Qian; Robert A Carr; Gary B Gordon; George D Demetri
Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(34):5583-8.
2008: Michael C Heinrich; ROBERT G MAKI; Christopher L Corless; Cristina R Antonescu; Amy Harlow; Diana Griffith; Ajia Town; Arin McKinley; Wen-Bin Ou; Jonathan A Fletcher; Christopher D M Fletcher; Xin Huang; Darrel P Cohen; Charles M Baum; George D Demetri
Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(33):5352-9.
2008: Michael C Heinrich; Kouros Owzar; Christopher L Corless; Donna Hollis; Ernest C Borden; Christopher D M Fletcher; Christopher W Ryan; Margaret von Mehren; Charles D Blanke; Cathryn Rankin; Robert S Benjamin; Vivien H C Bramwell; George D Demetri; Monica M Bertagnolli; Jonathan A Fletcher
Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(33):5360-7.
2008: Monica M Bertagnolli; Jeffrey A Morgan; Christopher D M Fletcher; Chandrajit P Raut; Palma Dileo; Ritu Gill; George D Demetri; Suzanne George
Multimodality treatment of mesenteric desmoid tumours.
European journal of cancer (Oxford, England : 1990) 2008;44(16):2404-10.
2008: Michael C Heinrich; Heikki Joensuu; George D Demetri; Christopher L Corless; Jane Apperley; Jonathan A Fletcher; Denis Soulieres; Stephan Dirnhofer; Amy Harlow; Ajia Town; Arin McKinley; Shane G Supple; John Seymour; Lilla Di Scala; Allan van Oosterom; Richard Herrmann; Zariana Nikolova; And Grant McArthur
Phase II, open-label study evaluating the activity of imatinib in treating life-threatening malignancies known to be associated with imatinib-sensitive tyrosine kinases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(9):2717-25.
2008: Minetta C Liu; George D Demetri; Donald A Berry; Larry Norton; Gloria Broadwater; Nicholas J Robert; David Duggan; Daniel F Hayes; I Craig Henderson; Alan Lyss; Judith Hopkins; Peter A Kaufman; Paul Kelly Marcom; Jerry Younger; Nancy U Lin; Katherine Tkaczuk; Eric P Winer; Clifford Hudis
Dose-escalation of filgrastim does not improve efficacy: clinical tolerability and long-term follow-up on CALGB study 9141 adjuvant chemotherapy for node-positive breast cancer patients using dose-intensified doxorubicin plus cyclophosphamide followed by paclitaxel.
Cancer treatment reviews 2008;34(3):223-30.
2008: F Stephen Hodi; Philip A Friedlander; Christopher L Corless; Michael C Heinrich; Suzanne Mac Rae; Andrea Kruse; Jyothi Jagannathan; Annick D Van den Abbeele; Elsa F Velazquez; George D Demetri; David E Fisher
Major response to imatinib mesylate in KIT-mutated melanoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(12):2046-51.
2008: Tejas V Patel; Jeffrey A Morgan; George D Demetri; Suzanne George; ROBERT G MAKI; Michael Quigley; Benjamin D Humphreys
A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib.
Journal of the National Cancer Institute 2008;100(4):282-4.
2008: Charles D Blanke; Cathryn Rankin; George D Demetri; Christopher W Ryan; Margaret von Mehren; Robert S Benjamin; A Kevin Raymond; Vivien H C Bramwell; Laurence H Baker; ROBERT G MAKI; Michael Tanaka; J Randolph Hecht; Michael C Heinrich; Christopher D M Fletcher; John J Crowley; Ernest C Borden
Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(4):626-32.
2008: Charles D Blanke; George D Demetri; Margaret von Mehren; Michael C Heinrich; Burton L Eisenberg; Jonathan A Fletcher; Christopher L Corless; Christopher D M Fletcher; Peter J Roberts; Daniela Heinz; Elisabeth Wehre; Zariana Nikolova; Heikki Joensuu
Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(4):620-5.
2008: Julie R Gralow; Robert F Ozols; Dean F Bajorin; Bruce D Cheson; Howard M Sandler; Eric P Winer; James Bonner; George D Demetri; Walter Curran; Patricia Anne Ganz; Barnett S Kramer; Mark G Kris; Maurie Markman; Robert J Mayer; Derek Raghavan; Scott Ramsey; Gregory H Reaman; Raymond Sawaya; Lynn Schuchter; John W Sweetenham; Linda Vahdat; Nancy E Davidson; Richard L Schilsky; Allen S Lichter
Clinical cancer advances 2007: major research advances in cancer treatment, prevention, and screening--a report from the American Society of Clinical Oncology.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(2):313-25.
2007: Tammy F Chu; Maria A Rupnick; Risto Kerkela; Susan M Dallabrida; David Zurakowski; Lisa Nguyen; Kathleen Woulfe; Elke Pravda; Flavia Cassiola; Jayesh Desai; Suzanne George; Jeffrey A Morgan; David M Harris; Nesreen S Ismail; Jey-Hsin Chen; Frederick J Schoen; Annick D Van den Abbeele; George D Demetri; Thomas Force; Ming Hui Chen
Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib.
Lancet 2007;370(9604):2011-9.
2007: George D Demetri
Structural reengineering of imatinib to decrease cardiac risk in cancer therapy.
The Journal of clinical investigation 2007;117(12):3650-3.
2007: Clay H Holdsworth; Ramsey D Badawi; Judith Manola; Marie Kijewski; David A Israel; George D Demetri; Annick D Van den Abbeele
CT and PET: early prognostic indicators of response to imatinib mesylate in patients with gastrointestinal stromal tumor.
AJR. American journal of roentgenology 2007;189(6):W324-30.
2007: Hiromichi Ito; Jason L Hornick; Monica M Bertagnolli; Suzanne George; Jeffrey A Morgan; Elizabeth Baldini; Andrew J Wagner; George D Demetri; Chandrajit P Raut
Leiomyosarcoma of the inferior vena cava: survival after aggressive management.
Annals of surgical oncology 2007;14(12):3534-41.
2007: S Bauer; Anette Duensing; George D Demetri; Jonathan A Fletcher
KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway.
Oncogene 2007;26(54):7560-8.
2007: M-J Zhu; W-B Ou; Christopher D M Fletcher; P S Cohen; George D Demetri; Jonathan A Fletcher
KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance.
Oncogene 2007;26(44):6386-95.
2007: Jayesh Desai; Sridhar Shankar; Michael C Heinrich; Jonathan A Fletcher; Christopher D Fletcher; Judith Manola; Jeffrey A Morgan; Christopher L Corless; Suzanne George; Kemal Tuncali; Stuart G Silverman; Annick D Van den Abbeele; Eric van Sonnenberg; George D Demetri
Clonal evolution of resistance to imatinib in patients with metastatic gastrointestinal stromal tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(18 Pt 1):5398-405.
2007: I Judson; George D Demetri
Advances in the treatment of gastrointestinal stromal tumours.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18 Suppl 10():x20-4.
2007: Sandrine Faivre; George D Demetri; William Sargent; Eric Raymond
Molecular basis for sunitinib efficacy and future clinical development.
Nature reviews. Drug discovery 2007;6(9):734-45.
2007: George D Demetri; Robert S Benjamin; Charles D Blanke; Jean-Yves Blay; Paolo Casali; Haesun Choi; Christopher L Corless; Maria Debiec-Rychter; Ronald P DeMatteo; David S Ettinger; George A Fisher; Christopher D M Fletcher; Alessandro Gronchi; Peter Hohenberger; Miranda Hughes; Heikki Joensuu; Ian Judson; Axel Le Cesne; ROBERT G MAKI; Michael Morse; Alberto S Pappo; Peter W T Pisters; Chandrajit P Raut; Peter Reichardt; Douglas S Tyler; Annick D Van den Abbeele; Margaret von Mehren; Jeffrey D Wayne; John Zalcberg
NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)--update of the NCCN clinical practice guidelines.
Journal of the National Comprehensive Cancer Network : JNCCN 2007;5 Suppl 2():S1-29; quiz S30.
2007: Federica Grosso; Robin L Jones; George D Demetri; Ian R Judson; Jean-Yves Blay; Axel Le Cesne; Roberta Sanfilippo; Paola Casieri; Paola Collini; Palma Dileo; Carlo Spreafico; Silvia Stacchiotti; Elena Tamborini; Juan C Tercero; José Jimeno; Maurizio D'Incalci; Alessandro Gronchi; Jonathan A Fletcher; Silvana Pilotti; Paolo G Casali
Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study.
The lancet oncology 2007;8(7):595-602.
2007: Anat Norden-Zfoni; Jayesh Desai; Judith Manola; Paul Beaudry; Jeremy Force; ROBERT G MAKI; Judah Folkman; Carlo L Bello; Charles Baum; Sam E DePrimo; David R Shalinsky; George D Demetri; John V Heymach
Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(9):2643-50.
2007: Palma Dileo; Jeffrey A Morgan; David Zahrieh; Jayesh Desai; Jeanine M Salesi; David C Harmon; M Travis Quigley; Kathleen Polson; George D Demetri; Suzanne George
Gemcitabine and vinorelbine combination chemotherapy for patients with advanced soft tissue sarcomas: results of a phase II trial.
Cancer 2007;109(9):1863-9.
2007: George D Demetri; Laurence H Baker; Robert S Benjamin; Ephraim S Casper; Ernest U Conrad; Gina Z D'Amato; Thomas F DeLaney; David S Ettinger; Robert K Heck; Martin J Heslin; Raymond J Hutchinson; Charlotte D Jacobs; Krystyna Kiel; William G Kraybill; G Douglas Letson; Richard J O'Donnell; I Benjamin Paz; John Pfeifer; Raphael E Pollock; R Lor Randall; Aaron R Sasson; Karen D Schupak; Douglas S Tyler; Margaret von Mehren; Jeffrey Wayne
Soft tissue sarcoma.
Journal of the National Comprehensive Cancer Network : JNCCN 2007;5(4):364-99.
2007: Roman K Thomas; Alissa C Baker; Ralph M Debiasi; Wendy Winckler; Thomas Laframboise; William M Lin; Meng Wang; Whei Feng; Thomas Zander; Laura MacConaill; Laura E Macconnaill; Jeffrey C Lee; Rick Nicoletti; Charlie Hatton; Mary Goyette; Luc Girard; Kuntal Majmudar; Liuda Ziaugra; Kwok-Kin Wong; Stacey Gabriel; Rameen Beroukhim; Michael Peyton; Jordi Barretina; Amit Dutt; Caroline Emery; Heidi Greulich; Kinjal Shah; Hidefumi Sasaki; Adi Gazdar; John Minna; Scott A Armstrong; Ingo K Mellinghoff; F Stephen Hodi; Glenn Dranoff; Paul Mischel; Tim F Cloughesy; Stan F Nelson; Linda M Liau; Kirsten Mertz; Mark A Rubin; Holger Moch; Massimo Loda; William Catalona; Jonathan Fletcher; Sabina Signoretti; Frederic Kaye; Kenneth C Anderson; George D Demetri; Reinhard Dummer; Stephan Wagner; Meenhard Herlyn; William R Sellers; Matthew Meyerson; Levi A Garraway
High-throughput oncogene mutation profiling in human cancer.
Nature genetics 2007;39(3):347-51.
2007: Steven DuBois; George D Demetri
Markers of angiogenesis and clinical features in patients with sarcoma.
Cancer 2007;109(5):813-9.
2007: Jeffrey Crawford; Betsy Althaus; James Armitage; Lodovico Balducci; Charles L Bennett; Douglas W Blayney; Spero R Cataland; David C Dale; George D Demetri; Harry P Erba; James Foran; Alison G Freifeld; Mark L Heaney; Sally Htoy; Dwight D Kloth; Gary H Lyman; Wells A Messersmith; Laura Boehnke Michaud; Sarah C Miyata; Amy Robbins; Martin S Tallman; Saroj Vadhan-Raj; Peter Westervelt; Michael K Wong
Myeloid growth factors. Clinical practice guidelines in oncology.
Journal of the National Comprehensive Cancer Network : JNCCN 2007;5(2):188-202.
2007: Danan Li; Hongbin Ji; Sara Zaghlul; Kate McNamara; Mei-Chih Liang; Takeshi Shimamura; Shigeto Kubo; Masaya Takahashi; Lucian R Chirieac; Robert F Padera; Andrew M Scott; Achim A Jungbluth; Webster K Cavenee; Lloyd J Old; George D Demetri; Kwok-Kin Wong
Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas.
The Journal of clinical investigation 2007;117(2):346-52.
2007: Ricardo J Wray; Jo Ellen Stryker; Eric Winer; George D Demetri; Karen M Emmons
Do cancer patients fully understand clinical trial participation? A pilot study to assess informed consent and patient expectations.
Journal of cancer education : the official journal of the American Association for Cancer Education 2007;22(1):21-4.
2007: Daniel M Huse; Margaret von Mehren; Gregory Lenhart; Heikki Joensuu; Charles D Blanke; Weiwei Feng; Stan Finkelstein; George D Demetri
Cost effectiveness of imatinib mesylate in the treatment of advanced gastrointestinal stromal tumours.
Clinical drug investigation 2007;27(2):85-93.
2006: Jayesh Desai; Leila Yassa; Ellen Marqusee; Suzanne George; Mary C Frates; Ming Hui Chen; Jeffrey A Morgan; Samuel Dychter; P Reed Larsen; George D Demetri; Erik K Alexander
Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors.
Annals of internal medicine 2006;145(9):660-4.
2006: Maurice Bernard Loughrey; Paul Waring; Alexander Dobrovic; George D Demetri; Sergey Kovalenko; Grant A McArthur
Polyclonal resistance in gastrointestinal stromal tumor treated with sequential kinase inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 1):6205-6; author reply 6206-7.
2006: George D Demetri; Allan T van Oosterom; Christopher R Garrett; Martin E Blackstein; Manisha H Shah; Jaap Verweij; Grant McArthur; Ian R Judson; Michael C Heinrich; Jeffrey A Morgan; Jayesh Desai; Christopher D Fletcher; Suzanne George; Carlo L Bello; Xin Huang; Charles M Baum; Paolo G Casali
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial.
Lancet 2006;368(9544):1329-38.
2006: Michael C Heinrich; Christopher L Corless; Charles D Blanke; George D Demetri; Heikki Joensuu; Peter J Roberts; Burton L Eisenberg; Margaret von Mehren; Christopher D M Fletcher; Katrin Sandau; Karen McDougall; Wen-bin Ou; Chang-Jie Chen; Jonathan A Fletcher
Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(29):4764-74.
2006: Jo Ellen Stryker; Ricardo J Wray; Karen M Emmons; Eric Winer; George D Demetri
Understanding the decisions of cancer clinical trial participants to enter research studies: factors associated with informed consent, patient satisfaction, and decisional regret.
Patient education and counseling 2006;63(1-2):104-9.
2006: Sebastian Bauer; Lynn K Yu; George D Demetri; Jonathan A Fletcher
Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor.
Cancer research 2006;66(18):9153-61.
2006: Thomas J Smith; James Khatcheressian; Gary H Lyman; Howard Ozer; James O Armitage; Lodovico Balducci; Charles L Bennett; Scott B Cantor; Jeffrey Crawford; Scott J Cross; George D Demetri; Christopher E Desch; Philip A Pizzo; Charles Alan Schiffer; Lee Schwartzberg; Mark R Somerfield; George Somlo; James C Wade; James L Wade Iii; Rodger J Winn; Antoinette J Wozniak; Antonio C Wolff
2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(19):3187-205.
2006: Chandrajit P Raut; Matthew Posner; Jayesh Desai; Jeffrey A Morgan; Suzanne George; David Zahrieh; Christopher D M Fletcher; George D Demetri; Monica M Bertagnolli
Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(15):2325-31.
2006: Suzanne George; Jayesh Desai; J Paul Eder; Judith Manola; David P Ryan; Leonard J Appleman; George D Demetri
Selective kinase inhibition with daily imatinib intensifies toxicity of chemotherapy in patients with solid tumours.
European journal of cancer (Oxford, England : 1990) 2006;42(7):864-70.
2006: Michael C Heinrich; Grant A McArthur; George D Demetri; Heikki Joensuu; Petri Bono; Richard Herrmann; Hal Hirte; Sara Cresta; D Bradley (Bradley) Koslin; Christopher L Corless; Stephan Dirnhofer; Allan T van Oosterom; Zariana Nikolova; Sasa Dimitrijevic; Jonathan A Fletcher
Clinical and molecular studies of the effect of imatinib on advanced aggressive fibromatosis (desmoid tumor).
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(7):1195-203.
2006: Roy S Herbst; Dean F Bajorin; Harry Bleiberg; Diane Blum; Desirée Hao; Bruce E Johnson; Robert F Ozols; George D Demetri; Patricia Anne Ganz; Mark G Kris; Bernard Levin; Maurie Markman; Derek Raghavan; Gregory H Reaman; Raymond Sawaya; Lynn Schuchter; John W Sweetenham; Linda Vahdat; Everett E Vokes; Rodger J Winn; Robert J Mayer
Clinical Cancer Advances 2005: major research advances in cancer treatment, prevention, and screening--a report from the American Society of Clinical Oncology.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(1):190-205.
2005: George M Rodgers; David Cella; Asher Chanan-Khan; Carolyn Chesney; Charles S Cleeland; Peter F. Coccia; George D Demetri; Benjamin Djulbegovic; Jennifer Garst; Margaret Gore; Eric H Kraut; Weei-Chin Lin; Michael Millenson; Victoria Mock; Denise Reinke; Joseph Rosenthal; Paul Sabbatini
Cancer- and treatment-related anemia.
Journal of the National Comprehensive Cancer Network : JNCCN 2005;3(6):772-89.
2005: Palma Dileo; George D Demetri
Update on new diagnostic and therapeutic approaches for sarcomas.
Clinical advances in hematology & oncology : H&O 2005;3(10):781-91.
2005: Rocio Garcia-Carbonero; Jeffrey G Supko; ROBERT G MAKI; Judith Manola; David P Ryan; David Harmon; Thomas A Puchalski; G Goss; Michael Seiden; A Waxman; M Travis Quigley; T Lopez; M A Sancho; José Jimeno; Cecilia Guzman; George D Demetri
Ecteinascidin-743 (ET-743) for chemotherapy-naive patients with advanced soft tissue sarcomas: multicenter phase II and pharmacokinetic study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(24):5484-92.
2005: Jeffrey Crawford; Betsy Althaus; James Armitage; Douglas W Blayney; Spero R Cataland; David C Dale; George D Demetri; James Foran; Mark L Heaney; Sally Htoy; Dwight D Kloth; Gary H Lyman; Laura Boehnke Michaud; Susannah Motl; Saroj Vadhan-Raj; Michael K Wong
Myeloid growth factors clinical practice guidelines in oncology.
Journal of the National Comprehensive Cancer Network : JNCCN 2005;3(4):540-55.
2005: Sridhar Shankar; Eric vanSonnenberg; Jayesh Desai; Pam J DiPiro; Annick D Van den Abbeele; George D Demetri
Gastrointestinal stromal tumor: new nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate.
Radiology 2005;235(3):892-8.
2005: Andre M Oliveira; Antonio R Perez-Atayde; Paola Dal Cin; Mark C Gebhardt; Chang-Jie Chen; James R Neff; George D Demetri; Andrew E Rosenberg; Julia A Bridge; Jonathan A Fletcher
Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes.
Oncogene 2005;24(21):3419-26.
2005: Frederick P Li; Jonathan A Fletcher; Michael C Heinrich; Judy E Garber; Stephen E Sallan; Clara Curiel-Lewandrowski; Anette Duensing; Matt van de Rijn; Lowell E Schnipper; George D Demetri
Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(12):2735-43.
2005: Jeanne M Griffin; Myra St Amand; George D Demetri
Nursing implications of imatinib as molecularly targeted therapy for gastrointestinal stromal tumors.
Clinical journal of oncology nursing 2005;9(2):161-9.
2005: Jean-Yves Blay; Sylvie Bonvalot; Paolo Casali; H Choi; M Debiec-Richter; A P Dei Tos; J-F Emile; Alessandro Gronchi; Pancras Hogendoorn; Heikki Joensuu; Axel Le Cesne; J McClure; J Mac Clure; J Maurel; N Nupponen; ISABELLE RAY COQUARD; P Reichardt; R Sciot; S Stroobants; Martine Van Glabbeke; Allan van Oosterom; George D Demetri
Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(4):566-78.
2005: George D Demetri; Laurence H Baker; Derrick J Beech; Robert Benjamin; Ephraim S Casper; Ernest U Conrad; Thomas F DeLaney; David S Ettinger; Martin J Heslin; Raymond J Hutchinson; Krystyna Kiel; William G Kraybill; G Douglas Letson; James Neff; Richard J O'Donnell; I Benjamin Paz; Raphael E Pollock; R Lor Randall; Karen D Schupak; Douglas S Tyler; Margaret von Mehren; Jeffrey Wayne
Soft tissue sarcoma clinical practice guidelines in oncology.
Journal of the National Comprehensive Cancer Network : JNCCN 2005;3(2):158-94.
2005: Grant A McArthur; George D Demetri; Allan van Oosterom; Michael C Heinrich; Maria Debiec-Rychter; Christopher L Corless; Zariana Nikolova; Sasa Dimitrijevic; Jonathan A Fletcher
Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(4):866-73.
2005: Paul Nikolaidis; Stuart G Silverman; Edmund S Cibas; Eric vanSonnenberg; Frank J Rybicki; Judith Manola; Kemal Tuncali; Steven H Karshbaum; Samuel Singer; Christopher D M Fletcher; George D Demetri
Liposarcoma subtypes: identification with computed tomography and ultrasound-guided percutaneous needle biopsy.
European radiology 2005;15(2):383-9.
2005: Darren W Davis; Ryan Takamori; Chandrajit P Raut; Henry Q Xiong; Roy S Herbst; Walter M Stadler; John V Heymach; George D Demetri; Asif Rashid; Yu Shen; Sijin Wen; James L Abbruzzese; David J McConkey
Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 1):678-89.
2005: Jayesh Desai; George D Demetri
Recombinant human erythropoietin in cancer-related anemia: an evidence-based review.
Best practice & research. Clinical haematology 2005;18(3):389-406.
2004: Stephen R Grobmyer; ROBERT G MAKI; George D Demetri; Madhu Mazumdar; Elyn Riedel; Murray F Brennan; Samuel Singer
Neo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(11):1667-72.
2004: George D Demetri; Ross L Titton; David P Ryan; Christopher D M Fletcher
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 32-2004. A 68-year-old man with a large retroperitoneal mass.
The New England journal of medicine 2004;351(17):1779-87.
2004: John V Heymach; Jayesh Desai; Judith Manola; Darren W Davis; David J McConkey; David Harmon; David P Ryan; Glenwood Goss; Travis Quigley; Annick D Van den Abbeele; Stuart G Silverman; Susan Connors; Judah Folkman; Christopher D M Fletcher; George D Demetri
Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(17):5732-40.
2004: Anette Duensing; Nora E Joseph; Fabiola Medeiros; Felicity Smith; Jason L Hornick; Michael C Heinrich; Christopher L Corless; George D Demetri; Christopher D M Fletcher; Jonathan A Fletcher
Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs).
Cancer research 2004;64(15):5127-31.
2004: Anette Duensing; Fabiola Medeiros; Bryna McConarty; Nora E Joseph; Dipak Panigrahy; Samuel Singer; Christopher D M Fletcher; George D Demetri; Jonathan A Fletcher
Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).
Oncogene 2004;23(22):3999-4006.
2004: George D Demetri; Burton L Eisenberg; Christopher D M Fletcher; ROBERT G MAKI; Brian P Rubin; Annick D Van den Abbeele; Margaret von Mehren; Robert Benjamin; Charles D Blanke; Haesun Choi; Chris Corless; Ronald P DeMatteo
NCCN Task Force report: optimal management of patients with gastrointestinal stromal tumor (GIST)--expansion and update of NCCN clinical practice guidelines.
Journal of the National Comprehensive Cancer Network : JNCCN 2004;2 Suppl 1():S-1-26; quiz 27-30.
2004: Rocio Garcia-Carbonero; Jeffrey G Supko; Judith Manola; Michael Seiden; David Harmon; David P Ryan; M Travis Quigley; P Merriam; J Canniff; G Goss; Ursula Matulonis; ROBERT G MAKI; T Lopez; Thomas A Puchalski; M A Sancho; J Gomez; Cecilia Guzman; José Jimeno; George D Demetri
Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(8):1480-90.
2004: Petri Bono; Andreas Krause; Margaret von Mehren; Michael C Heinrich; Charles D Blanke; Sasa Dimitrijevic; George D Demetri; Heikki Joensuu
Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib.
Blood 2004;103(8):2929-35.
2004: Mandeep S Saund; George D Demetri; Stanley W Ashley
Gastrointestinal stromal tumors (GISTs).
Current opinion in gastroenterology 2004;20(2):89-94.
2004: Paul J Hesketh; Francis Arena; Dhimant Patel; Matt Austin; Paul D'Avirro; Gregory Rossi; Alan Colowick; Lee Schwartzberg; Luigi F Bertoli; John T Cole; George D Demetri; Emmanuel Dessypris; Tracy Dobbs; Peter Eisenberg; Roger Fleischman; James Hall; Phillip C Hoffman; Damian A Laber; John Leonard; Eric P Lester; Spence McCachren; Scott McMeekin; Luis Meza; David Scott Miller; Sucha Nand; Ira Oliff; Warren Paroly; Larry Pawl; Alejandra Perez; Harry Raftopoulos; James Rigas; Jr. Kendrith M. Rowland; Daniel C Scullin; Haluk Tezcan; John Waples; John Ward; Lorrin K Yee
A randomized controlled trial of darbepoetin alfa administered as a fixed or weight-based dose using a front-loading schedule in patients with anemia who have nonmyeloid malignancies.
Cancer 2004;100(4):859-68.
2004: Jared R Adams; Linda S Elting; Gary H Lyman; James N George; Barry C Lembersky; James O Armitage; George D Demetri; Charles L Bennett
Use of erythropoietin in cancer patients: assessment of oncologists' practice patterns in the United States and other countries.
The American journal of medicine 2004;116(1):28-34.
2003: Joseph R Mace; Mary-Louise Keohan; Heinz Bernardy; Klaus Junge; Georg Niebch; Peter Romeis; Aangelika Thoma; Thomas Wagner; Udo Mueller; George D Demetri; Laurence H Baker
Crossover randomized comparison of intravenous versus intravenous/oral mesna in soft tissue sarcoma treated with high-dose ifosfamide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(16 Pt 1):5829-34.
2003: Michael C Heinrich; Christopher L Corless; George D Demetri; Charles D Blanke; Margaret von Mehren; Heikki Joensuu; Laura McGreevey; Chang-Jie Chen; Annick D Van den Abbeele; Brian J Druker; Beate Kiese; Burton L Eisenberg; Peter J Roberts; Samuel Singer; Christopher D M Fletcher; Sandra Silberman; Sasa Dimitrijevic; Jonathan A Fletcher
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(23):4342-9.
2003: M J Janicek; George D Demetri; M R Janicek; K Shaffer; M A Fauci
Dynamic infrared imaging of newly diagnosed malignant lymphoma compared with Gallium-67 and Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography.
Technology in cancer research & treatment 2003;2(6):571-8.
2003: George D Demetri
OncoloGIST, BioloGIST, RadioloGIST: the big impact on the field of oncology of a molecularly-targeted therapy designed to treat a rare disease.
European journal of cancer (Oxford, England : 1990) 2003;39(14):1976-7.
2003: Caroline Laverdiere; E Anders Kolb; Jeffrey G Supko; Richard Gorlick; Paul A Meyers; ROBERT G MAKI; Leonard H Wexler; George D Demetri; John Healey; Andrew G Huvos; Allen M Goorin; Rochelle Bagatell; Ana Ruiz-Casado; Cecilia Guzman; José Jimeno; David Harmon
Phase II study of ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma.
Cancer 2003;98(4):832-40.
2003: Harold J Burstein; George D Demetri; Elisabetta Mueller; pasha sarraf; Bruce M Spiegelman; Eric P Winer
Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study.
Breast cancer research and treatment 2003;79(3):391-7.
2003: Ernest C Borden; Laurence H Baker; Robert S Bell; Vivien Bramwell; George D Demetri; Burton L Eisenberg; Christopher D M Fletcher; Jonathan A Fletcher; Marc Ladanyi; Paul Meltzer; Brian O'Sullivan; David R Parkinson; Peter W T Pisters; Scott Saxman; Samuel Singer; Murali Sundaram; Allan T van Oosterom; Jaap Verweij; Jill Waalen; Sharon W Weiss; Murray F Brennan
Soft tissue sarcomas of adults: state of the translational science.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(6):1941-56.
2003: Francisco J Esteva; John Glaspy; Said Baidas; Leslie R Laufman; Laura F Hutchins; Maura Dickler; Debu Tripathy; Roger Cohen; Angela DeMichele; Richard C Yocum; C Kent Osborne; Daniel F Hayes; Gabriel N Hortobagyi; Eric Winer; George D Demetri
Multicenter phase II study of oral bexarotene for patients with metastatic breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(6):999-1006.
2003: I Craig Henderson; Donald A Berry; George D Demetri; Constance Cirrincione; Lori J Goldstein; Silvana Martino; James N Ingle; M Robert Cooper; Daniel F Hayes; Katherine Tkaczuk; Gini Fleming; James F Holland; David B Duggan; John T Carpenter; Emil Frei; Richard L Schilsky; William C Wood; Hyman Muss; Larry Norton
Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(6):976-83.
2003: Michael C Heinrich; Christopher L Corless; Anette Duensing; Laura McGreevey; Chang-Jie Chen; Nora E Joseph; Samuel Singer; Diana J Griffith; Andrea Haley; Ajia Town; George D Demetri; Christopher D M Fletcher; Jonathan A Fletcher
PDGFRA activating mutations in gastrointestinal stromal tumors.
Science (New York, N.Y.) 2003;299(5607):708-10.
2003: Suzanne George; Jason L Hornick; Monica M Bertagnolli; Christopher D M Fletcher; George D Demetri
Current management of metastatic gastrointestinal stromal tumor: a case report.
Clinical advances in hematology & oncology : H&O 2003;1(1):63-4; discussion 65.
2002: Jennifer R Brown; George D Demetri
Challenges in the development of platelet growth factors: low expectations for low counts.
Current hematology reports 2002;1(2):110-8.
2002: Heikki Joensuu; Christopher Fletcher; Sasa Dimitrijevic; Sandra Silberman; Peter Roberts; George D Demetri
Management of malignant gastrointestinal stromal tumours.
The lancet oncology 2002;3(11):655-64.
2002: George D Demetri
Targeting the molecular pathophysiology of gastrointestinal stromal tumors with imatinib. Mechanisms, successes, and challenges to rational drug development.
Hematology/oncology clinics of North America 2002;16(5):1115-24.
2002: Thomas A Puchalski; David P Ryan; Rocio Garcia-Carbonero; George D Demetri; Leah Butkiewicz; David Harmon; Michael Seiden; ROBERT G MAKI; Luis Lopez-Lazaro; José Jimeno; Cecilia Guzman; Jeffrey G Supko
Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients with soft tissue sarcomas: associations with clinical characteristics, pathophysiological variables and toxicity.
Cancer chemotherapy and pharmacology 2002;50(4):309-19.
2002: Samuel Singer; Brian P Rubin; Marcia L Lux; Chang-Jie Chen; George D Demetri; Christopher D M Fletcher; Jonathan A Fletcher
Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(18):3898-905.
2002: George D Demetri
Identification and treatment of chemoresistant inoperable or metastatic GIST: experience with the selective tyrosine kinase inhibitor imatinib mesylate (STI571).
European journal of cancer (Oxford, England : 1990) 2002;38 Suppl 5():S52-9.
2002: Matthew H Kulke; George D Demetri; Norman E Sharpless; David P Ryan; Ramesh A Shivdasani; Jeffrey S Clark; Bruce M Spiegelman; Haesook T Kim; Robert J Mayer; Charlie S Fuchs
A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer.
Cancer journal (Sudbury, Mass.) 2002;8(5):395-9.
2002: Jeffrey Crawford; David Cella; Charles S Cleeland; Pierre-Yves Cremieux; George D Demetri; Brenda J Sarokhan; Mitchell B Slavin; John A Glaspy
Relationship between changes in hemoglobin level and quality of life during chemotherapy in anemic cancer patients receiving epoetin alfa therapy.
Cancer 2002;95(4):888-95.
2002: George D Demetri; Margaret von Mehren; Charles D Blanke; Annick D Van den Abbeele; Burton L Eisenberg; Peter J Roberts; Michael C Heinrich; David A Tuveson; Samuel Singer; Milos J Janicek; Jonathan A Fletcher; Stuart G Silverman; Sandra Silberman; Renaud Capdeville; Beate Kiese; Bin Peng; Sasa Dimitrijevic; Brian J Druker; Christopher L Corless; Christopher D M Fletcher; Heikki Joensuu
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.
The New England journal of medicine 2002;347(7):472-80.
2002: George D Demetri
ET-743: the US experience in sarcomas of soft tissues.
Anti-cancer drugs 2002;13 Suppl 1():S7-9.
2002: Ronald P DeMatteo; Michael C Heinrich; Wa'el M El-Rifai; George D Demetri
Clinical management of gastrointestinal stromal tumors: before and after STI-571.
Human pathology 2002;33(5):466-77.
2002: George D Demetri; Janice L Gabrilove; Michael V Blasi; Richard J Hill; John Glaspy
Benefits of epoetin alfa in anemic breast cancer patients receiving chemotherapy.
Clinical breast cancer 2002;3(1):45-51.
2002: Deborah Toppmeyer; Andrew D Seidman; Michael Pollak; Christy Russell; Katherine Tkaczuk; Shailendra Verma; Beth Overmoyer; Varun Garg; Ene I Ette; Matthew W Harding; George D Demetri
Safety and efficacy of the multidrug resistance inhibitor Incel (biricodar; VX-710) in combination with paclitaxel for advanced breast cancer refractory to paclitaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(3):670-8.
2002: Jeffrey Crawford; George D Demetri; Janice L Gabrilove; Michael V Blasi; Brenda J Sarokhan; John Glaspy
Clinical benefits of epoetin alfa therapy in patients with lung cancer.
Clinical lung cancer 2002;3(3):180-90.
2002: Vivien H C Bramwell; Donald Morris; D Scott Ernst; Ingrid Hings; Martin E Blackstein; Peter M Venner; Ene I Ette; Matthew W Harding; Allison Waxman; George D Demetri
Safety and efficacy of the multidrug-resistance inhibitor biricodar (VX-710) with concurrent doxorubicin in patients with anthracycline-resistant advanced soft tissue sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):383-93.
2002: David P Ryan; Thomas A Puchalski; Jeffrey G Supko; David Harmon; ROBERT G MAKI; Rocio Garcia-Carbonero; Caroline Kuhlman; Jennifer Winkelman; Priscilla Merriam; Travis Quigley; José Jimeno; Judith Manola; George D Demetri
A phase II and pharmacokinetic study of ecteinascidin 743 in patients with gastrointestinal stromal tumors.
The oncologist 2002;7(6):531-8.
2002: George D Demetri
GIST 1, chemotherapy 0, with a brand new hitter up next.
Cancer investigation 2002;20(5-6):853-4.
2002: John Glaspy; Laurent Degos; Mario Dicato; George D Demetri
Comparable efficacy of epoetin alfa for anemic cancer patients receiving platinum- and nonplatinum-based chemotherapy: a retrospective subanalysis of two large, community-based trials.
The oncologist 2002;7(2):126-35.
2001: Brian P Rubin; Samuel Singer; C Tsao; Anette Duensing; Marcia L Lux; R Ruiz; MK Hibbard; Chang-Jie Chen; Sheng Xiao; D A Tuveson; George D Demetri; Christopher D M Fletcher; Jonathan A Fletcher
KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.
Cancer research 2001;61(22):8118-21.
2001: George D Demetri; T Delaney
NCCN: Sarcoma.
Cancer control : journal of the Moffitt Cancer Center 2001;8(6 Suppl 2):94-101.
2001: George D Demetri
NCCN: New applications for erythropoietin.
Cancer control : journal of the Moffitt Cancer Center 2001;8(6 Suppl 2):72-6.
2001: George D Demetri
Targeting c-kit mutations in solid tumors: scientific rationale and novel therapeutic options.
Seminars in oncology 2001;28(5 Suppl 17):19-26.
2001: David A Tuveson; Nicholas A Willis; Tyler Jacks; James D Griffin; Samuel Singer; C D Fletcher; J A Fletcher; George D Demetri
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications.
Oncogene 2001;20(36):5054-8.
2001: Nestor F. Esnaola; B P Rubin; Elizabeth Baldini; N Vasudevan; George D Demetri; C D Fletcher; Samuel Singer
Response to chemotherapy and predictors of survival in adult rhabdomyosarcoma.
Annals of surgery 2001;234(2):215-23.
2001: Heikki Joensuu; Peter J Roberts; Maarit Sarlomo-Rikala; Leif C Andersson; Pekka Tervahartiala; David A Tuveson; Sandra Silberman; Renaud Capdeville; Sasa Dimitrijevic; Brian J Druker; George D Demetri
Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor.
The New England journal of medicine 2001;344(14):1052-6.
2001: George D Demetri
Anaemia and its functional consequences in cancer patients: current challenges in management and prospects for improving therapy.
British journal of cancer 2001;84 Suppl 1():31-7.
2001: John Glaspy; Jaswant Sinh Jadeja; Glen Justice; J Kessler; D Richards; L Schwartzberg; J Rigas; David J Kuter; D Harmon; D Prow; George D Demetri; D Gordon; J Arseneau; A Saven; H Hynes; Ralph V Boccia; J O'Byrne; Alan B Colowick
A dose-finding and safety study of novel erythropoiesis stimulating protein (NESP) for the treatment of anaemia in patients receiving multicycle chemotherapy.
British journal of cancer 2001;84 Suppl 1():17-23.
2001: Anthony D Elias; Paul Richardson; David Avigan; Joseph G Ibrahim; Robin M Joyce; George D Demetri; J Levine; D Warren; T Arthur; E Reich; C Wheele; Emil Frei; Lois Jeanne Ayash
A short course of induction chemotherapy followed by two cycles of high-dose chemotherapy with stem cell rescue for chemotherapy naive metastatic breast cancer.
Bone marrow transplantation 2001;27(3):269-78.
2001: David P Ryan; Jeffrey G Supko; Joseph P Eder; Michael Seiden; George D Demetri; Thomas J Lynch; A J Fischman; J Davis; J Jimeno; jeffrey clark
Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(2):231-42.
2001: George D Demetri
Targeted approaches for the treatment of thrombocytopenia.
The oncologist 2001;6 Suppl 5():15-23.
2001: E S Cibas; G A Goss; Matthew H Kulke; George D Demetri; Christopher D M Fletcher
Malignant epithelioid angiomyolipoma ('sarcoma ex angiomyolipoma') of the kidney: a case report and review of the literature.
The American journal of surgical pathology 2001;25(1):121-6.
2000: K K Fields; M Crump; I Bence-Bruckler; S Bernstein; S Williams; S Frankel; Alan Marshall Miller; George D Demetri; J M Nabholtz; S Cruickshank; M Lill
Use of PEG-rHuMGDF in platelet engraftment after autologous stem cell transplantation.
Bone marrow transplantation 2000;26(10):1083-8.
2000: Howard Ozer; J O Armitage; Charles L Bennett; Jeffrey Crawford; George D Demetri; P A Pizzo; Charles Alan Schiffer; Thomas J Smith; G Somlo; J C Wade; James L Wade Iii; Rodger J Winn; Antoinette J Wozniak; Mark R Somerfield
2000 update of recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines. American Society of Clinical Oncology Growth Factors Expert Panel.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(20):3558-85.
2000: Samuel Singer; George D Demetri; Elizabeth Baldini; C D Fletcher
Management of soft-tissue sarcomas: an overview and update.
The lancet oncology 2000;1():75-85.
2000: Elisabetta Mueller; M Smith; pasha sarraf; Todd G Kroll; A Aiyer; D S Kaufman; William K Oh; George D Demetri; W D Figg; X P Zhou; Charis Eng; Bruce M Spiegelman; Philip W Kantoff
Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10990-5.
2000: G Goss; George D Demetri
Medical management of unresectable, recurrent low-grade retroperitoneal liposarcoma: integration of cytotoxic and non-cytotoxic therapies into multimodality care.
Surgical oncology 2000;9(2):53-9.
2000: Gerard C Blobe; M Mantel; Milos J Janicek; George D Demetri
Two patients with sarcoma. Case 2. Uterine sarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(11):2343-4.
2000: George D Demetri
Pharmacologic treatment options in patients with thrombocytopenia.
Seminars in hematology 2000;37(2 Suppl 4):11-8.
2000: Marcia L Lux; Brian P Rubin; T L Biase; Chang-Jie Chen; T Maclure; George D Demetri; Sheng Xiao; Samuel Singer; Christopher D M Fletcher; Jonathan A Fletcher
KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors.
The American journal of pathology 2000;156(3):791-5.
1999: Jonathan W Friedberg; Annick D Van den Abbeele; K Kehoe; Samuel Singer; Christopher D M Fletcher; George D Demetri
Uptake of radiolabeled somatostatin analog is detectable in patients with metastatic foci of sarcoma.
Cancer 1999;86(8):1621-7.
1999: Elizabeth Baldini; J Goldberg; C Jenner; J B Manola; George D Demetri; C D Fletcher; Samuel Singer
Long-term outcomes after function-sparing surgery without radiotherapy for soft tissue sarcoma of the extremities and trunk.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(10):3252-9.
1999: Elizabeth Baldini; George D Demetri; Christopher D M Fletcher; J Foran; Karen C Marcus; Samuel Singer
Adults with Ewing's sarcoma/primitive neuroectodermal tumor: adverse effect of older age and primary extraosseous disease on outcome.
Annals of surgery 1999;230(1):79-86.
1999: George D Demetri; Christopher D M Fletcher; Elisabetta Mueller; pasha sarraf; R Naujoks; N Campbell; Bruce M Spiegelman; Samuel Singer
Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3951-6.
1998: George D Demetri; Mark G Kris; James L Wade Iii; L Degos; David Cella
Quality-of-life benefit in chemotherapy patients treated with epoetin alfa is independent of disease response or tumor type: results from a prospective community oncology study. Procrit Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(10):3412-25.
1998: David Avigan; Paul Richardson; A Elias; George D Demetri; M Shapiro; Lowell E Schnipper; C Wheeler
Neutropenic enterocolitis as a complication of high dose chemotherapy with stem cell rescue in patients with solid tumors: a case series with a review of the literature.
Cancer 1998;83(3):409-14.
1998: George D Demetri
Major developments in the understanding and treatment of soft-tissue sarcomas in adults.
Current opinion in oncology 1998;10(4):343-7.
1998: George D Demetri; R Pollock; Laurence H Baker; S Balcerzak; E Casper; C Conrad; D Fein; Raymond J Hutchinson; K Schupak; I Spiro; L Wagman
NCCN sarcoma practice guidelines. National Comprehensive Cancer Network.
Oncology (Williston Park, N.Y.) 1998;12(7A):183-218.
1998: J F Amatruda; K Tran; M Mantel; Samuel Singer; George D Demetri
Diagnosis in oncology. Askin tumor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(5):1997-8.
1997: Robert H Vonderheide; Mark D Fleming; G Carter; Samuel Singer; George D Demetri
Angiosarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(4):1708-9.
1997: Charles L Shapiro; Lois Jeanne Ayash; Iain Webb; Rebecca Gelman; J Keating; L Williams; George D Demetri; P Clark; A Elias; David B Duggan; Daniel F Hayes; David D Hurd; I Craig Henderson
Repetitive cycles of cyclophosphamide, thiotepa, and carboplatin intensification with peripheral-blood progenitor cells and filgrastim in advanced breast cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(2):674-83.
1997: D C West; Holcombe E Grier; M M Swallow; George D Demetri; Linda Granowetter; Jeffrey Sklar
Detection of circulating tumor cells in patients with Ewing's sarcoma and peripheral primitive neuroectodermal tumor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(2):583-8.
1996: George D Demetri; A Elias; D Gershenson; F Fossella; J Grecula; B Mittal; J Raschko; J Robertson
NCCN Small-Cell Lung Cancer Practice Guidelines. The National Comprehensive Cancer Network.
Oncology (Williston Park, N.Y.) 1996;10(11 Suppl):179-94.
1996: George D Demetri
High-dose ifosfamide in the treatment of sarcomas of soft tissues and bone.
Seminars in oncology 1996;23(3 Suppl 6):22-6.
1996: J J Costa; George D Demetri; T J Harrist; Ann M Dvorak; Daniel F Hayes; E A Merica; D M Menchaca; A J Gringeri; L B Schwartz; Stephen J Galli
Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo.
The Journal of experimental medicine 1996;183(6):2681-6.
1996: George D Demetri
The emergence of peripheral blood progenitor cells to support intensive chemotherapy for patients with breast cancer.
Pharmacotherapy 1996;16(3 Pt 2):94S-100S.
1996: S K Kim; George D Demetri
Chemotherapy and neutropenia.
Hematology/oncology clinics of North America 1996;10(2):377-95.
1996: Samuel Singer; Elizabeth Baldini; George D Demetri; Jonathan A Fletcher; J M Corson
Synovial sarcoma: prognostic significance of tumor size, margin of resection, and mitotic activity for survival.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(4):1201-8.
1996: Iain Webb; C E Eickhoff; Anthony D Elias; Lois Jeanne Ayash; C A Wheeler; G N Schwartz; George D Demetri; Kenneth C Anderson
Kinetics of peripheral blood mononuclear cell mobilization with chemotherapy and/or granulocyte-colony-stimulating factor: implications for yield of hematopoietic progenitor cell collections.
Transfusion 1996;36(2):160-7.
1995: George D Demetri; Anthony D Elias
Results of single-agent and combination chemotherapy for advanced soft tissue sarcomas. Implications for decision making in the clinic.
Hematology/oncology clinics of North America 1995;9(4):765-85.
1995: George D Demetri
Hematopoietic growth factors. Defining the appropriate clinical role in multimodality cancer therapy.
Chest 1995;107(6 Suppl):255S-260S.
1995: Samuel Singer; J M Corson; George D Demetri; E A Healey; Karen Marcus; Timothy J Eberlein
Prognostic factors predictive of survival for truncal and retroperitoneal soft-tissue sarcoma.
Annals of surgery 1995;221(2):185-95.
1995: Dean F Bajorin; Craig Nichols; H J Schmoll; Philip W Kantoff; C Bokemeyer; George D Demetri; L H Einhorn; George J Bosl
Recombinant human granulocyte-macrophage colony-stimulating factor as an adjunct to conventional-dose ifosfamide-based chemotherapy for patients with advanced or relapsed germ cell tumors: a randomized trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(1):79-86.
1994: Richard M Stone; Steven H Bernstein; George D Demetri; D P Facklam; K Arthur; J Andersen; Jon C Aster; Donald Kufe
Therapy with recombinant human erythropoietin in patients with myelodysplastic syndromes.
Leukemia research 1994;18(10):769-76.
1994: Ravi Salgia; George D Demetri; W D Kaplan
Changes in Tc-99m radionuclide bone scan images and peripheralization of marrow hematopoietic activity associated with the administration of granulocyte colony stimulating factor as an adjunct to dose-intensified chemotherapy for breast cancer. A case report.
Cancer 1994;74(7):1887-90.
1994: I Tepler; A Elias; L Kalish; L Shulman; G Strauss; A Skarin; T Lynch; D Levitt; D Resta; George D Demetri
Effect of recombinant human interleukin-3 on haematological recovery from chemotherapy-induced myelosuppression.
British journal of haematology 1994;87(4):678-86.
1994: Lois Jeanne Ayash; A Elias; M Hunt; George D Demetri; C Wheeler; I Tepler; Gary Schwartz; R Mazanet; E Reich; Mary McCauley
Recombinant human erythropoietin for the treatment of the anaemia associated with autologous bone marrow transplantation.
British journal of haematology 1994;87(1):153-61.
1994: G Morstyn; S Brown; M Gordon; J Crawford; George D Demetri; W Rich; B McGuire; M Foote; Ian K McNiece
Stem cell factor is a potent synergistic factor in hematopoiesis.
Oncology 1994;51(2):205-14.
1994: George D Demetri
The use of hematopoietic growth factors to support cytotoxic chemotherapy for patients with breast cancer.
Hematology/oncology clinics of North America 1994;8(1):233-49.
1993: George D Demetri
Beyond supportive care: what are the next questions in the use of hematopoietic cytokines with cytotoxic chemotherapy?
Blood 1993;82(8):2278-80.
1993: S Park; Martin Schalling; A Bernard; Shyamala Maheswaran; G C Shipley; D Roberts; J Fletcher; R Shipman; J Rheinwald; George D Demetri
The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma.
Nature genetics 1993;4(4):415-20.
1993: I Tepler; Stephen A Cannistra; Emil Frei; R Gonin; Kenneth C Anderson; George D Demetri; J Niloff; H Goodman; H Muntz; M Muto
Use of peripheral-blood progenitor cells abrogates the myelotoxicity of repetitive outpatient high-dose carboplatin and cyclophosphamide chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(8):1583-91.
1993: S N Rabinowe; Donna Neuberg; P J Bierman; J M Vose; John Nemunaitis; jack w singer; Arnold S Freedman; Peter M Mauch; George D Demetri; N Onetto
Long-term follow-up of a phase III study of recombinant human granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for lymphoid malignancies.
Blood 1993;81(7):1903-8.
1993: George D Demetri
Impact of hematopoietic growth factors on the management of small-cell lung cancer.
Chest 1993;103(4 Suppl):427S-432S.
1993: George P Canellos; George D Demetri
Myelosuppression and "conventional" chemotherapy: what price, what benefit?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(1):1-2.
1992: George D Demetri; Karen Antman
Granulocyte-macrophage colony-stimulating factor (GM-CSF): preclinical and clinical investigations.
Seminars in oncology 1992;19(4):362-85.
1992: George D Demetri
Hematopoietic growth factors: current knowledge, future prospects.
Current problems in cancer 1992;16(4):177-259.
1991: George D Demetri; James D Griffin
Granulocyte colony-stimulating factor and its receptor.
Blood 1991;78(11):2791-808.
1990: George D Demetri; T J Ernst; E S Pratt; B W Zenzie; J G Rheinwald; James D Griffin
Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes.
The Journal of clinical investigation 1990;86(4):1261-9.
1990: Saul J Sharkis; Richard J Jones; M L Bellis; George D Demetri; James D Griffin; Curt I Civin; W S May
The action of bryostatin on normal human hematopoietic progenitors is mediated by accessory cell release of growth factors.
Blood 1990;76(4):716-20.
1990: George D Demetri; James D Griffin
Hematopoietic growth factors and high-dose chemotherapy: will grams succeed where milligrams fail?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(5):761-4.
1990: James D Griffin; George D Demetri; Y Kanakura; Stephen A Cannistra; T J Ernst
Cellular interaction regulating the production of colony-stimulating factors.
Progress in clinical and biological research 1990;338():129-41.
1990: James D Griffin; Stephen A Cannistra; R Sullivan; George D Demetri; T J Ernst; Y Kanakura
The biology of GM-CSF: regulation of production and interaction with its receptor.
International journal of cell cloning 1990;8 Suppl 1():35-44; discussion 44-5.
1989: M Nakamura; S Merchav; A Carter; T J Ernst; George D Demetri; Y Furukawa; Kenneth C Anderson; Arnold S Freedman; James D Griffin
Expression of a novel 3.5-kb macrophage colony-stimulating factor transcript in human myeloma cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3543-7.
1989: Kenneth A Bauer; E M Conway; R Bach; W H Konigsberg; James D Griffin; George D Demetri
Tissue factor gene expression in acute myeloblastic leukemia.
Thrombosis research 1989;56(3):425-30.
1989: George D Demetri; David Spriggs; M L Sherman; K A Arthur; K Imamura; Donald Kufe
A phase I trial of recombinant human tumor necrosis factor and interferon-gamma: effects of combination cytokine administration in vivo.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(10):1545-53.
1989: George D Demetri; James D Griffin
Hemopoietins and leukemia.
Hematology/oncology clinics of North America 1989;3(3):535-53.
1989: George D Demetri; B W Zenzie; J G Rheinwald; James D Griffin
Expression of colony-stimulating factor genes by normal human mesothelial cells and human malignant mesothelioma cells lines in vitro.
Blood 1989;74(3):940-6.
1989: Thomas F Tedder; C M Isaacs; T J Ernst; George D Demetri; D A Adler; C M Disteche
Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins.
The Journal of experimental medicine 1989;170(1):123-33.
1989: Peter Brouckaert; David Spriggs; George D Demetri; Donald Kufe; Walter Fiers
Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma.
The Journal of experimental medicine 1989;169(6):2257-62.
1989: T J Ernst; A R Ritchie; George D Demetri; James D Griffin
Regulation of granulocyte- and monocyte-colony stimulating factor mRNA levels in human blood monocytes is mediated primarily at a post-transcriptional level.
The Journal of biological chemistry 1989;264(10):5700-3.
1988: D C Young; George D Demetri; T J Ernst; Stephen A Cannistra; James D Griffin
In vitro expression of colony-stimulating factor genes by human acute myeloblastic leukemia cells.
Experimental hematology 1988;16(5):378-82.
1980: C Savakis; George D Demetri; P Cherbas
Ecdysteroid-inducible polypeptides in a Drosophila cell line.
Cell 1980;22(3):665-74.