Costas Demetzos

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Spyratou Ellas; Mourelatou Elena A; Makropoulou Mersini; Demetzos Costas
Atomic force microscopy: a tool to study the structure, dynamics and stability of liposomal drug delivery systems.
Deli Georgia; Hatziantoniou Sophia; Nikas Yorgos; Demetzos Costas
Solid lipid nanoparticles and nanoemulsions containing ceramides: preparation and physicochemical characterization.
Falara Vasiliki; Fotopoulos Vasileios; Margaritis Thanasis; Anastasaki Thalia; Pateraki Irene; Bosabalidis Artemios M; Kafetzopoulos Dimitris; Demetzos Costas; Pichersky Eran; Kanellis Angelos K
Transcriptome analysis approaches for the isolation of trichome-specific genes from the medicinal plant Cistus creticus subsp. creticus.

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2009: Spyratou Ellas; Mourelatou Elena A; Makropoulou Mersini; Demetzos Costas
Atomic force microscopy: a tool to study the structure, dynamics and stability of liposomal drug delivery systems.
Expert opinion on drug delivery 2009;6(3):305-17.
2009: Deli Georgia; Hatziantoniou Sophia; Nikas Yorgos; Demetzos Costas
Solid lipid nanoparticles and nanoemulsions containing ceramides: preparation and physicochemical characterization.
Journal of liposome research 2009;19(3):180-8.
2008: Falara Vasiliki; Fotopoulos Vasileios; Margaritis Thanasis; Anastasaki Thalia; Pateraki Irene; Bosabalidis Artemios M; Kafetzopoulos Dimitris; Demetzos Costas; Pichersky Eran; Kanellis Angelos K
Transcriptome analysis approaches for the isolation of trichome-specific genes from the medicinal plant Cistus creticus subsp. creticus.
Plant molecular biology 2008;68(6):633-51.
2008: Koukoulitsa Catherine; Zervou Maria; Demetzos Costas; Mavromoustakos Thomas
Comparative docking studies of labdane-type diterpenes with forskolin at the active site of adenylyl cyclase.
Bioorganic & medicinal chemistry 2008;16(17):8237-43.
2008: Mozafari M Reza; Johnson Chad; Hatziantoniou Sophia; Demetzos Costas
Nanoliposomes and their applications in food nanotechnology.
Journal of liposome research 2008;18(4):309-27.
2008: Villalonga-Barber Carolina; Micha-Screttas Maria; Steele Barry R; Georgopoulos Aristidis; Demetzos Costas
Dendrimers as biopharmaceuticals: synthesis and properties.
Current topics in medicinal chemistry 2008;8(14):1294-309.
2008: Demetzos Costas
Differential Scanning Calorimetry (DSC): a tool to study the thermal behavior of lipid bilayers and liposomal stability.
Journal of liposome research 2008;18(3):159-73.
2007: Markatou Eleni; Gionis Vassilis; Chryssikos Georgios D; Hatziantoniou Sophia; Georgopoulos Aristidis; Demetzos Costas
Molecular interactions between dimethoxycurcumin and Pamam dendrimer carriers.
International journal of pharmaceutics 2007;339(1-2):231-6.
2007: Dimas Konstantinos; Hatziantoniou Sophia; Tseleni Sophia; Khan Humaira; Georgopoulos Aristidis; Alevizopoulos Konstantinos; Wyche James H; Pantazis Panayotis; Demetzos Costas
Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice.
Apoptosis : an international journal on programmed cell death 2007;12(4):685-94.
2007: Paradissis Agnès; Hatziantoniou Sophia; Georgopoulos Aristidis; Psarra Anna-Maria G; Dimas Konstantinos; Demetzos Costas
Liposomes modify the subcellular distribution of sclareol uptake by HCT-116 cancer cell lines.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2007;61(2-3):120-4.
2007: Matsingou Christina; Demetzos Costas
Calorimetric study on the induction of interdigitated phase in hydrated DPPC bilayers by bioactive labdanes and correlation to their liposome stability: The role of chemical structure.
Chemistry and physics of lipids 2007;145(1):45-62.
2007: Hatziantoniou S; Deli G; Nikas Y; Demetzos C; Papaioannou G Th
Scanning electron microscopy study on nanoemulsions and solid lipid nanoparticles containing high amounts of ceramides.
Micron (Oxford, England : 1993) 2007;38(8):819-23.
2007: Hatziantoniou Sophia; Nezis Ioannis P; Margaritis Lukas H; Demetzos Costas
Visualisation of liposomes prepared from skin and stratum corneum lipids by transmission electron microscopy.
Micron (Oxford, England : 1993) 2007;38(8):777-81.
2007: Matsingou Christina; Demetzos Costas
Effect of the nature of the 3beta-substitution in manoyl oxides on the thermotropic behavior of DPPC lipid bilayer and on DPPC liposomes.
Journal of liposome research 2007;17(2):89-105.
2006: Koukoulitsa C; Kyrikou I; Demetzos C; Mavromoustakos T
The role of the anticancer drug vinorelbine in lipid bilayers using differential scanning calorimetry and molecular modeling.
Chemistry and physics of lipids 2006;144(1):85-95.
2006: Gardikis Konstantinos; Hatziantoniou Sophia; Viras Kyriakos; Wagner Matthias; Demetzos Costas
A DSC and Raman spectroscopy study on the effect of PAMAM dendrimer on DPPC model lipid membranes.
International journal of pharmaceutics 2006;318(1-2):118-23.
2006: Matsingou Christina; Dimas Kostas; Demetzos Costas
Design and development of liposomes incorporating a bioactive labdane-type diterpene. In vitro growth inhibiting and cytotoxic activity against human cancer cell lines.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2006;60(4):191-9.
2006: Dimas K; Papadaki M; Tsimplouli C; Hatziantoniou S; Alevizopoulos K; Pantazis P; Demetzos C
Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2006;60(3):127-33.
2006: Papagiannaros A; Hatziantoniou S; Lelong-Rebel I H; Papaioannou G T; Dimas K; Demetzos C
Antitumor activity of doxorubicin encapsulated in hexadecylphosphocholine (HePC) liposomes against human xenografts on Scid mice.
In vivo (Athens, Greece) 2006;20(1):129-35.
2006: Papagiannaros Aristarchos; Hatziantoniou Sophia; Dimas Konstantinos; Papaioannou George Th; Demetzos Costas
A liposomal formulation of doxorubicin, composed of hexadecylphosphocholine (HePC): physicochemical characterization and cytotoxic activity against human cancer cell lines.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2006;60(1):36-42.
2006: Hatziantoniou Sophia; Dimas Konstantinos; Georgopoulos Aristidis; Sotiriadou Nektaria; Demetzos Costas
Cytotoxic and antitumor activity of liposome-incorporated sclareol against cancer cell lines and human colon cancer xenografts.
Pharmacological research : the official journal of the Italian Pharmacological Society 2006;53(1):80-7.
2006: Saroglou V; Hatziantoniou S; Smyrniotakis M; Kyrikou I; Mavromoustakos T; Zompra A; Magafa V; Cordopatis P; Demetzos C
Synthesis, liposomal formulation and thermal effects on phospholipid bilayers of leuprolide.
Journal of peptide science : an official publication of the European Peptide Society 2006;12(1):43-50.
2006: Hatziantoniou Sophia; Demetzos Costas
Qualitative and quantitative one-step analysis of lipids and encapsulated bioactive molecules in liposome preparations by HPTLC/FID (IATROSCAN).
Journal of liposome research 2006;16(4):321-30.
2006: Alexopoulou Elena; Georgopoulos Aristidis; Kagkadis Konstantinos A; Demetzos Costas
Preparation and characterization of lyophilized liposomes with incorporated quercetin.
Journal of liposome research 2006;16(1):17-25.
2005: Papagiannaros A; Bories C; Demetzos C; Loiseau P M
Antileishmanial and trypanocidal activities of new miltefosine liposomal formulations.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2005;59(10):545-50.
2005: Matsingou Christina; Hatziantoniou Sophia; Georgopoulos Aristidis; Dimas Kostas; Terzis Aris; Demetzos Costas
Labdane-type diterpenes: thermal effects on phospholipid bilayers, incorporation into liposomes and biological activity.
Chemistry and physics of lipids 2005;138(1-2):1-11.
2005: Saroglou Vasiliki; Karioti Anastasia; Demetzos Costas; Dimas Kostas; Skaltsa Helen
Sesquiterpene lactones from Centaurea spinosa and their antibacterial and cytotoxic activities.
Journal of natural products 2005;68(9):1404-7.
2005: Papagiannaros Aristarchos; Dimas Kostas; Papaioannou George Th; Demetzos Costas
Doxorubicin-PAMAM dendrimer complex attached to liposomes: cytotoxic studies against human cancer cell lines.
International journal of pharmaceutics 2005;302(1-2):29-38.
2005: Kaourma E; Hatziantoniou S; Georgopoulos A; Kolocouris A; Demetzos C
Development of simple thiol-reactive liposome formulations, one-step analysis and physicochemical characterization.
The Journal of pharmacy and pharmacology 2005;57(4):527-31.
2005: Economakis Costas; Karioti Anastasia; Skaltsa Helen; Perdetzoglou Dimitrios; Demetzos Costas
Effect of solution conductivity on the volatile constituents of Origanum dictamnus L. in nutrient film culture.
Journal of agricultural and food chemistry 2005;53(5):1656-60.
2005: Kyrikou I; Georgopoulos A; Hatziantoniou S; Mavromoustakos T; Demetzos C
A comparative study of the effects of cholesterol and sclareol, a bioactive labdane type diterpene, on phospholipid bilayers.
Chemistry and physics of lipids 2005;133(2):125-34.
2005: Balan Kannan V; Demetzos Costas; Prince Jeffrey; Dimas Konstantine; Cladaras Margarita; Han Zhiyong; Wyche James H; Pantazis Panayotis
Induction of apoptosis in human colon cancer HCT116 cells treated with an extract of the plant product, Chios mastic gum.
In vivo (Athens, Greece) 2005;19(1):93-102.
2004: Hatzellis Konstantinos; Pagona Georgia; Spyros Apostolos; Demetzos Costas; Katerinopoulos Haralambos E
Correction of the structure of a new sesquiterpene from Cistus creticus ssp. creticus.
Journal of natural products 2004;67(12):1996-2001.
2004: Goniotaki M; Hatziantoniou S; Dimas K; Wagner M; Demetzos C
Encapsulation of naturally occurring flavonoids into liposomes: physicochemical properties and biological activity against human cancer cell lines.
The Journal of pharmacy and pharmacology 2004;56(10):1217-24.
2004: Malisiova Fotini; Hatziantoniou Sophia; Dimas Kostas; Kletstas Dimitrios; Demetzos Costas
Liposomal formulations from phospholipids of Greek almond oil. Properties and biological activity.
Zeitschrift für Naturforschung. C, Journal of biosciences 2004;59(5-6):330-4.
2004: Hatziantoniou Sophia; Giamarellos-Bourboulis Evangelos J; Skiathitis Sotirios; Demetzos Constantinos; Donta Ismini; Papaioannou George Th; Dionyssiou-Asteriou Amalia; Karayannacos Panayotis E; Giamarellou Helen
Rapid alterations of serum fatty acids with the intravenous administration of an arachidonate solution.
Prostaglandins, leukotrienes, and essential fatty acids 2004;70(5):465-8.
2004: Kyrikou Ioanna; Daliani Ioanna; Mavromoustakos Thomas; Maswadeh Hamzah; Demetzos Costas; Hatziantoniou Sophia; Giatrellis Sarantis; Nounesis George
The modulation of thermal properties of vinblastine by cholesterol in membrane bilayers.
Biochimica et biophysica acta 2004;1661(1):1-8.
2003: Karioti A; Skaltsa H; Demetzos C; Perdetzoglou D; Economakis C D; Salem A B
Effect of nitrogen concentration of the nutrient solution on the volatile constituents of leaves of Salvia fruticosa Mill. in solution culture.
Journal of agricultural and food chemistry 2003;51(22):6505-8.
2003: Skaltsa Helen D; Demetzos Costas; Lazari Diamanto; Sokovic Marina
Essential oil analysis and antimicrobial activity of eight Stachys species from Greece.
Phytochemistry 2003;64(3):743-52.
2003: Karkabounas Spyridon; Kiortsis Dimitrios Nikiforos; Zelovitis John; Skafida Panagiota; Demetzos Costas; Malamas Michail; Elisaf Moses; Evangelou Angelos
Effects of Cupressus sempervirens cone extract on lipid parameters in Wistar rats.
In vivo (Athens, Greece) 2003;17(1):101-3.
2002: Maswadeh H; Demetzos C; Daliani I; Kyrikou I; Mavromoustakos T; Tsortos A; Nounesis G
A molecular basis explanation of the dynamic and thermal effects of vinblastine sulfate upon dipalmitoylphosphatidylcholine bilayer membranes.
Biochimica et biophysica acta 2002;1567(1-2):49-55.
2002: Demetzos Costas; Kolocouris Antonios; Anastasaki Thalia
A simple and rapid method for the differentiation of C-13 manoyl oxide epimers in biologically important samples using GC-MS analysis supported with NMR spectroscopy and computational chemistry results.
Bioorganic & medicinal chemistry letters 2002;12(24):3605-9.
2002: Economakis C; Skaltsa Helen; Demetzos Costas; Sokovic M; Thanos Costas A
Effect of phosphorus concentration of the nutrient solution on the volatile constituents of leaves and bracts of Origanum dictamnus.
Journal of agricultural and food chemistry 2002;50(22):6276-80.
2002: Koukoulitsa Ekaterini; Skaltsa Helen; Karioti Anastasia; Demetzos Costas; Dimas Kostas
Bioactive sesquiterpene lactones from Centaurea species and their cytotoxic/cytostatic activity against human cell lines in vitro.
Planta medica 2002;68(7):649-52.
2002: Maswadeh H; Demetzos C; Dimas K; Loukas Y L; Georgopoulos A; Mavromoustakos T; Papaioannou G Th
In-vitro cytotoxic/cytostatic activity of anionic liposomes containing vinblastine against leukaemic human cell lines.
The Journal of pharmacy and pharmacology 2002;54(2):189-96.
2002: Demetzos Costas; Anastasaki Thalia; Perdetzoglou Dimitrios
A chemometric interpopulation study of the essential oils of Cistus creticus L. growing in Crete (Greece).
Zeitschrift für Naturforschung. C, Journal of biosciences 2002;57(1-2):89-94.
2002: Tsamouris George; Hatziantoniou Sophia; Demetzos Costas
Lipid analysis of Greek walnut oil (Juglans regia L.).
Zeitschrift für Naturforschung. C, Journal of biosciences 2002;57(1-2):51-6.
2001: Demetzos C; Perdetzoglou D; Tan K
Chemical analysis and antimicrobial activity of Halimium voldii.
Zeitschrift für Naturforschung. C, Journal of biosciences 2001;56(11-12):979-82.
2001: Demetzos C; Dimas K; Hatziantoniou S; Anastasaki T; Angelopoulou D
Cytotoxic and anti-inflammatory activity of labdane and cis-clerodane type diterpenes.
Planta medica 2001;67(7):614-8.
2001: Maswadeh H; Demetzos C; Dimas K; Hatziantoniou S; Georgopoulos A; Rallis M; Dallas P; Papaioannou G
Accumulation of vinblastine into transfersomes and liposomes in response to a transmembrane ammonium sulfate gradient and their cytotoxic/cytostatic activity in vitro.
Anticancer research 2001;21(4A):2577-83.
2001: Dimas K; Demetzos C; Vaos V; Ioannidis P; Trangas T
Labdane type diterpenes down-regulate the expression of c-Myc protein, but not of Bcl-2, in human leukemia T-cells undergoing apoptosis.
Leukemia research 2001;25(6):449-54.
2001: Mavromoustakos T; Calogeropoulou T; Koufaki M; Kolocouris A; Daliani I; Demetzos C; Meng Z; Makriyannis A; Balzarini J; De Clercq E
Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers.
Journal of medicinal chemistry 2001;44(11):1702-9.
2001: Angelopoulou D; Demetzos C; Dimas C; Perdetzoglou D; Loukis A
Essential oils and hexane extracts from leaves and fruits of Cistus monspeliensis. Cytotoxic activity of ent-13-epi-manoyl oxide and its isomers.
Planta medica 2001;67(2):168-71.
2001: Kolocouris A; Mavromoustakos T; Demetzos C; Terzis A; Grdadolnik S G
Structure elucidation and conformational properties of a novel bioactive clerodane diterpene using a combination of high field NMR spectroscopy, computational analysis and X-ray diffraction.
Bioorganic & medicinal chemistry letters 2001;11(6):837-40.
2000: Maswadeh H; Hatziantoniou S; Demetzos C; Dimas K; Georgopoulos A; Rallis M
Encapsulation of vinblastine into new liposome formulations prepared from triticum (wheat germ) lipids and its activity against human leukemic cell lines.
Anticancer research 2000;20(6B):4385-90.
2000: Dimas K; Demetzos C; Angelopoulou D; Kolokouris A; Mavromoustakos T
Biological activity of myricetin and its derivatives against human leukemic cell lines in vitro.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;42(5):475-8.
2000: Demetzos C; Perdetzoglou D; Gazouli M; Tan K; Economakis C
Chemical analysis and antimicrobial studies on three species of Ferulago from Greece.
Planta medica 2000;66(6):560-3.
2000: Hatziantoniou S; Rallis M; Demetzos C; Papaioannou G T
Pharmacological activity of natural lipids on a skin barrier disruption model.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;42(1):55-9.
2000: Dimas K; Demetzos C; Mitaku S; Marselos M; Tzavaras T; Kokkinopoulos D
Cytotoxic activity of kaempferol glycosides against human leukaemic cell lines in vitro.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;41(1):85-8.
1999: Anastasaki T; Demetzos C; Perdetzoglou D; Gazouli M; Loukis A; Harvala C
Analysis of labdane-type diterpenes from Cistus creticus (subsp. creticus and subsp. eriocephalus), by GC and GC-MS.
Planta medica 1999;65(8):735-9.
1999: Dimas K; Demetzos C; Vaos B; Marselos M; Kokkinopoulos D
Cytotoxic and antiproliferative effects of heptaacetyltiliroside on human leukemic cell lines.
Leukemia research 1999;23(11):1021-33.
1999: Dimas K; Demetzos C; Mitaku S; Vaos B; Marselos M; Tzavaras T; Kokkinopoulos D
Cytotoxic activity and antiproliferative effects of a new semi-synthetic derivative of Ent-3 beta-hydroxy-13-epi-manoyl oxide on human leukemic cell lines.
Anticancer research 1999;19(5B):4065-72.
1999: Economakis C; Demetzos C; Anastassaki T; Papazoglou V; Gazouli M; Loukis A; Thanos C A; Harvala C
Volatile constituents of bracts and leaves of wild and cultivated Origanum dictamnus.
Planta medica 1999;65(2):189-91.
1999: Dimas K; Kokkinopoulos D; Demetzos C; Vaos B; Marselos M; Malamas M; Tzavaras T
The effect of sclareol on growth and cell cycle progression of human leukemic cell lines.
Leukemia research 1999;23(3):217-34.
1999: Demetzos C; Stahl B; Anastassaki T; Gazouli M; Tzouvelekis L S; Rallis M
Chemical analysis and antimicrobial activity of the resin Ladano, of its essential oil and of the isolated compounds.
Planta medica 1999;65(1):76-8.
1998: Dimas K; Demetzos C; Marsellos M; Sotiriadou R; Malamas M; Kokkinopoulos D
Cytotoxic activity of labdane type diterpenes against human leukemic cell lines in vitro.
Planta medica 1998;64(3):208-11.
1997: Demetzos C; Katerinopoulos H; Kouvarakis A; Stratigakis N; Loukis A; Ekonomakis C; Spiliotis V; Tsaknis J
Composition and antimicrobial activity of the essential oil of Cistus creticus subsp. eriocephalus.
Planta medica 1997;63(5):477-9.
1997: Demetzos C; Magiatis P; Typas M A; Dimas K; Sotiriadou R; Perez S; Kokkinopoulos D
Biotransformation of the flavonoid tiliroside to 7-methylether tiliroside: bioactivity of this metabolite and of its acetylated derivative.
Cellular and molecular life sciences : CMLS 1997;53(7):587-92.
1994: Chinou I; Demetzos C; Harvala C; Roussakis C; Verbist J F
Cytotoxic and antibacterial labdane-type diterpenes from the aerial parts of Cistus incanus subsp. creticus.
Planta medica 1994;60(1):34-6.
1993: Mitrokotsa D; Mitaku S; Demetzos C; Harvala C; Mentis A; Perez S; Kokkinopoulos D
Bioactive compounds from the buds of Platanus orientalis and isolation of a new kaempferol glycoside.
Planta medica 1993;59(6):517-20.
1989: Demetzos C; Mitaku S; Hotellier F; Harvala A
[Polyphenolic glycosides from Cistus creticus L. leaves]
Annales pharmaceutiques françaises 1989;47(5):314-8.

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Costas Demetzos

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