Preview
Sign-in for full Details 
Sign-in free and Explore the Exciting World of BiomedExperts:
- Over 1.500.000 Profiles
- More than 1.800 Organizations worldwide
- State of the Art Network Visualizations
- Manage your own Profile
- Locate Experts in your Country/Region
- Locate Experts in your 1. and 2. Level Network
- Connect to Experts Worldwide
NetworkView
Hans-Ulrich Demuth
This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers
together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles
free of charge to researchers worldwide.
Research Profile (preview)
Chemicals & Drugs
Concepts & Ideas
Genes & Molecular Sequences
Living Beings
Procedures
Phenomena
Sign-in to see full Profile
Network (preview)
33
Hoffmann, Torsten
30
McIntosh, Christopher
29
Pederson, Raymond
19
Manhart, Susanne
15
Heiser, Ulrich
14
Schilling, Stephan
14
Hinke, Simon
11
Wermann, Michael
10
Pospisilik, Andrew
10
Rosche, Fred
10
Kühn-Wache, Kerstin
8
Rahfeld, Jens-Ulrich
6
Gerhartz, Bernd
6
Wagner, Leona
6
Wasternack, Claus
Sign-in to see all Coauthors
Publications
Sign-in to see all Publications
Sign in free and see...
Visualized networks:
See your personal network in
sophisticated graphical views
GeoTargeted Searches:
Locate experts around the world
and connect with global collaborators
Research Profiles:
See the visualized research activity
of experts around the globe
Sign-in to see more
Geonetwork of Hans-Ulrich Demuth (preview)
Cities where this author has publications
Cities where co-authors of this author have publications
Sign-in to see more
All Publications
-
2009: Hartlage-Rübsamen Maike; Staffa Katharina; Waniek Alexander; Wermann Michael; Hoffmann Torsten; Cynis Holger; Schilling Stephan; Demuth Hans-Ulrich; Rossner Steffen
Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2009;27(8):825-35.
-
2009: Schlenzig Dagmar; Manhart Susanne; Cinar Yeliz; Kleinschmidt Martin; Hause Gerd; Willbold Dieter; Funke Susanne Aileen; Schilling Stephan; Demuth Hans-Ulrich
Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides.
Biochemistry 2009;48(29):7072-8.
-
2009: Frerker Nadine; Raber Kerstin; Bode Felix; Skripuletz Thomas; Nave Heike; Klemann Christian; Pabst Reinhard; Stephan Michael; Schade Jutta; Brabant Georg; Wedekind Dirk; Jacobs Roland; Jörns Anne; Forssmann Ulf; Straub Rainer H; Johannes Sigrid; Hoffmann Torsten; Wagner Leona; Demuth Hans-Ulrich; von Hörsten Stephan
Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2009;47(3):275-87.
-
2008: Schilling Stephan; Zeitschel Ulrike; Hoffmann Torsten; Heiser Ulrich; Francke Mike; Kehlen Astrid; Holzer Max; Hutter-Paier Birgit; Prokesch Manuela; Windisch Manfred; Jagla Wolfgang; Schlenzig Dagmar; Lindner Christiane; Rudolph Thomas; Reuter Gunter; Cynis Holger; Montag Dirk; Demuth Hans-Ulrich; Rossner Steffen
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.
Nature medicine 2008;14(10):1106-11.
-
2008: Böhme Livia; Hoffmann Torsten; Manhart Susanne; Wolf Raik; Demuth Hans-Ulrich
Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases.
Biological chemistry 2008;389(8):1055-66.
-
2008: Böhme Livia; Bär Joachim Wolfgang; Hoffmann Torsten; Manhart Susanne; Ludwig Hans-Henning; Rosche Fred; Demuth Hans-Ulrich
Isoaspartate residues dramatically influence substrate recognition and turnover by proteases.
Biological chemistry 2008;389(8):1043-53.
-
2008: Schilling Stephan; Wasternack Claus; Demuth Hans-Ulrich
Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution.
Biological chemistry 2008;389(8):983-91.
-
2008: Schilling Stephan; Appl Thomas; Hoffmann Torsten; Cynis Holger; Schulz Katrin; Jagla Wolfgang; Friedrich Daniel; Wermann Michael; Buchholz Mirko; Heiser Ulrich; von Hörsten Stephan; Demuth Hans-Ulrich
Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.
Journal of neurochemistry 2008;106(3):1225-36.
-
2008: Cynis Holger; Scheel Eike; Saido Takaomi C; Schilling Stephan; Demuth Hans-Ulrich
Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.
Biochemistry 2008;47(28):7405-13.
-
2008: Cynis Holger; Rahfeld Jens-Ulrich; Stephan Anett; Kehlen Astrid; Koch Birgit; Wermann Michael; Demuth Hans-Ulrich; Schilling Stephan
Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.
Journal of molecular biology 2008;379(5):966-80.
-
2008: Schade Jutta; Stephan Michael; Schmiedl Andreas; Wagner Leona; Niestroj André J; Demuth Hans-Ulrich; Frerker Nadine; Klemann Christian; Raber Kerstin A; Pabst Reinhard; von Hörsten Stephan
Regulation of expression and function of dipeptidyl peptidase 4 (DP4), DP8/9, and DP10 in allergic responses of the lung in rats.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008;56(2):147-55.
-
2008: Xu Yue; Nakajima Yoshitaka; Ito Kiyoshi; Zheng Heng; Oyama Hiroshi; Heiser Ulrich; Hoffmann Torsten; Gärtner Ulf-Torsten; Demuth Hans-Ulrich; Yoshimoto Tadashi
Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism.
Journal of molecular biology 2008;375(3):708-19.
-
2007: Piteau Shalea; Olver Amy; Kim Su-Jin; Winter Kyle; Pospisilik John Andrew; Lynn Francis; Manhart Susanne; Demuth Hans-Ulrich; Speck Madeleine; Pederson Raymond A; McIntosh Christopher H S
Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat.
Biochemical and biophysical research communications 2007;362(4):1007-12.
-
2007: Schilling Stephan; Lindner Christiane; Koch Birgit; Wermann Michael; Rahfeld Jens-Ulrich; von Bohlen Alex; Rudolph Thomas; Reuter Gunter; Demuth Hans-Ulrich
Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.
Biochemistry 2007;46(38):10921-30.
-
2007: Parthier Christoph; Kleinschmidt Martin; Neumann Piotr; Rudolph Rainer; Manhart Susanne; Schlenzig Dagmar; Fanghänel Jörg; Rahfeld Jens-Ulrich; Demuth Hans-Ulrich; Stubbs Milton T
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):13942-7.
-
2007: Friedrich Daniel; Hoffmann Torsten; Bär Joachim; Wermann Michael; Manhart Susanne; Heiser Ulrich; Demuth Hans-Ulrich
Does human attractin have DP4 activity?
Biological chemistry 2007;388(2):155-62.
-
2007: Schilling Stephan; Stenzel Irene; von Bohlen Alex; Wermann Michael; Schulz Katrin; Demuth Hans-Ulrich; Wasternack Claus
Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.
Biological chemistry 2007;388(2):145-53.
-
2007: Frerker Nadine; Wagner Leona; Wolf Raik; Heiser Ulrich; Hoffmann Torsten; Rahfeld Jens-Ulrich; Schade Jutta; Karl Tim; Naim Hassan Y; Alfalah Marwan; Demuth Hans-Ulrich; von Hörsten Stephan
Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4.
Peptides 2007;28(2):257-68.
-
2006: Schilling Stephan; Lauber Thomas; Schaupp Michael; Manhart Susanne; Scheel Eike; Böhm Gerald; Demuth Hans-Ulrich
On the seeding and oligomerization of pGlu-amyloid peptides (in vitro).
Biochemistry 2006;45(41):12393-9.
-
2006: Cynis Holger; Schilling Stephan; Bodnár Mandy; Hoffmann Torsten; Heiser Ulrich; Saido Takaomi C; Demuth Hans-Ulrich
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.
Biochimica et biophysica acta 2006;1764(10):1618-25.
-
2006: Unniappan S; McIntosh C H S; Demuth H-U; Heiser U; Wolf R; Kieffer T J
Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY.
Diabetologia 2006;49(8):1915-23.
-
2006: Buchholz Mirko; Heiser Ulrich; Schilling Stephan; Niestroj André J; Zunkel Katrin; Demuth Hans-Ulrich
The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship.
Journal of medicinal chemistry 2006;49(2):664-77.
-
2006: Engel Michael; Hoffmann Torsten; Manhart Susanne; Heiser Ulrich; Chambre Sylvie; Huber Robert; Demuth Hans-Ulrich; Bode Wolfram
Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.
Journal of molecular biology 2006;355(4):768-83.
-
2006: Wagner Leona; Hoffmann Torsten; Rahfeld Jens-Ulrich; Demuth Hans-Ulrich
Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR.
Advances in experimental medicine and biology 2006;575():109-16.
-
2006: Bär Joachim Wolfgang; Rahfeld Jens-Ulrich; Schulz Ingo; Gans Kathrin; Ruiz-Carrillo David; Manhart Susanne; Rosche Fred; Demuth Hans-Ulrich
Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity.
Advances in experimental medicine and biology 2006;575():103-8.
-
2006: McIntosh Christopher H S; Demuth Hans-Ulrich; Kim Su-Jin; Pospisilik J Andrew; Pederson Raymond A
Applications of dipeptidyl peptidase IV inhibitors in diabetes mellitus.
The international journal of biochemistry & cell biology 2006;38(5-6):860-72.
-
2005: Schilling Stephan; Cynis Holger; von Bohlen Alex; Hoffmann Torsten; Wermann Michael; Heiser Ulrich; Buchholz Mirko; Zunkel Katrin; Demuth Hans-Ulrich
Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.
Biochemistry 2005;44(40):13415-24.
-
2005: Schulz Ingo; Zeitschel Ulrike; Rudolph Thomas; Ruiz-Carrillo David; Rahfeld Jens-Ulrich; Gerhartz Bernd; Bigl Volker; Demuth Hans-Ulrich; Rossner Steffen
Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion.
Journal of neurochemistry 2005;94(4):970-9.
-
2005: Demuth Hans-Ulrich; McIntosh Christopher H S; Pederson Raymond A
Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors.
Biochimica et biophysica acta 2005;1751(1):33-44.
-
2005: Rossner Steffen; Schulz Ingo; Zeitschel Ulrike; Schliebs Reinhard; Bigl Volker; Demuth Hans-Ulrich
Brain prolyl endopeptidase expression in aging, APP transgenic mice and Alzheimer's disease.
Neurochemical research 2005;30(6-7):695-702.
-
2005: McIntosh Christopher H S; Demuth Hans-Ulrich; Pospisilik J Andrew; Pederson Raymond
Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents?
Regulatory peptides 2005;128(2):159-65.
-
2004: Hinke Simon A; Manhart Susanne; Speck Madeleine; Pederson Raymond A; Demuth Hans-Ulrich; McIntosh Christopher H S
In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide.
Life sciences 2004;75(15):1857-70.
-
2004: Rüter Jens; Hoffmann Torsten; Demuth Hans-Ulrich; Moschansky Petra; Klapp Burghard F; Hildebrandt Martin
Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice.
Biological chemistry 2004;385(6):537-41.
-
2004: Schilling Stephan; Hoffmann Torsten; Manhart Susanne; Hoffmann Matthias; Demuth Hans-Ulrich
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.
FEBS letters 2004;563(1-3):191-6.
-
2004: Wolf Raik; Hoffmann Torsten; Rosche Fred; Demuth Hans-Ulrich
Simultaneous determination of incretin hormones and their truncated forms from human plasma by immunoprecipitation and liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;803(1):91-9.
-
2004: Hinke Simon A; Manhart Susanne; Kühn-Wache Kerstin; Nian Cuilan; Demuth Hans-Ulrich; Pederson Raymond A; McIntosh Christopher H S
[Ser2]- and [SerP2] incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo.
The Journal of biological chemistry 2004;279(6):3998-4006.
-
2003: Schilling Stephan; Manhart Susanne; Hoffmann Torsten; Ludwig Hans-Henning; Wasternack Claus; Demuth Hans-Ulrich
Substrate specificity of glutaminyl cyclases from plants and animals.
Biological chemistry 2003;384(12):1583-92.
-
2003: Bär Joachim; Weber Anja; Hoffmann Torsten; Stork Jörg; Wermann Michael; Wagner Leona; Aust Susanne; Gerhartz Bernd; Demuth Hans-Ulrich
Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme.
Biological chemistry 2003;384(12):1553-63.
-
2003: Schilling Stephan; Niestroj André J; Rahfeld Jens-Ulrich; Hoffmann Torsten; Wermann Michael; Zunkel Katrin; Wasternack Claus; Demuth Hans-Ulrich
Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators.
The Journal of biological chemistry 2003;278(50):49773-9.
-
2003: Meyer Antje; Gourinchas Elisabeth; Girault Jacques; Demuth Hans-Ulrich
Quantitative analysis of dipeptidyl peptidase inhibitor P32/98 and its main metabolite in rat, dog, mouse, monkey, human plasma and human urine using liquid chromatography-tandem mass spectrometry: application to pharmacokinetic evaluation.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;796(2):401-11.
-
2003: Ehses Jan A; Casilla Vanbric R; Doty Tim; Pospisilik J Andrew; Winter Kyle D; Demuth Hans-Ulrich; Pederson Raymond A; McIntosh Christopher H S
Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase.
Endocrinology 2003;144(10):4433-45.
-
2003: Engel Michael; Hoffmann Torsten; Wagner Leona; Wermann Michael; Heiser Ulrich; Kiefersauer Reiner; Huber Robert; Bode Wolfram; Demuth Hans-Ulrich; Brandstetter Hans
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5063-8.
-
2003: Hinke Simon A; Gelling Rick; Manhart Susanne; Lynn Francis; Pederson Raymond A; Kühn-Wache Kerstin; Rosche Fred; Demuth Hans-Ulrich; Coy David; McIntosh Christopher H S
Structure-activity relationships of glucose-dependent insulinotropic polypeptide (GIP).
Biological chemistry 2003;384(3):403-7.
-
2003: Manhart Susanne; Hinke Simon A; McIntosh Christopher H S; Pederson Raymond A; Demuth Hans-Ulrich
Structure-function analysis of a series of novel GIP analogues containing different helical length linkers.
Biochemistry 2003;42(10):3081-8.
-
2003: Pospisilik J Andrew; Martin Jennifer; Doty Timothy; Ehses Jan A; Pamir Nathalie; Lynn Francis C; Piteau Shalea; Demuth Hans-Ulrich; McIntosh Christopher H S; Pederson Raymond A
Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.
Diabetes 2003;52(3):741-50.
-
2003: Niestroj André J; Schlenzig Dagmar; Heiser Ulrich; Kühn-Wache Kerstin; Cigic Blas; Werman Michael; Hoffmann Torsten; Gerhartz Bernd; Demuth Hans-Ulrich
Acylated hydroxamates as selective and highly potent inhibitors of dipeptidyl peptidase I.
Advances in experimental medicine and biology 2003;524():339-43.
-
2003: Hinke Simon A; Lynn Francis; Ehses Jan; Pamir Nathalie; Manhart Susanne; Kühn-Wache Kerstin; Rosche Fred; Demuth Hans-Ulrich; Pederson Raymond A; McIntosh Christopher H S
Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential.
Advances in experimental medicine and biology 2003;524():293-301.
-
2003: Pospisilik J Andrew; Ehses Jan A; Doty Timothy; McIntosh Christopher H S; Demuth Hans-Ulrich; Pederson Raymond A
Dipeptidyl peptidase IV inhibition in animal models of diabetes.
Advances in experimental medicine and biology 2003;524():281-91.
-
2003: Rüter Jens; Demuth Hans-Ulrich; Arck Petra C; Hoffmann Torsten; Klapp Burghard F; Hildebrandt Martin
Inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity modulates surface expression of CTLA-4 in stress-induced abortions.
Advances in experimental medicine and biology 2003;524():155-63.
-
2003: Stork Joerg; Hoffmann Torsten; Demuth Hans-Ulrich
Investigation of DP IV-dependent protein-protein interactions using surface plasmon resonance.
Advances in experimental medicine and biology 2003;524():115-9.
-
2003: Friedrich Daniel; Kühn-Wache Kerstin; Hoffmann Torsten; Demuth Hans-Ulrich
Isolation and characterization of attractin-2.
Advances in experimental medicine and biology 2003;524():109-13.
-
2003: Baer Joachim W; Gerhartz Bernd; Hoffmann Torsten; Rosche Fred; Demuth Hans-Ulrich
Characterisation of human DP IV produced by a Pichia pastoris expression system.
Advances in experimental medicine and biology 2003;524():103-8.
-
2003: Kühn-Wache Kerstin; Hoffmann Torsten; Manhart Susanne; Brandt W; Demuth Hans-Ulrich
The specificity of DP IV for natural substrates is peptide structure determined.
Advances in experimental medicine and biology 2003;524():57-63.
-
2002: Rüter Jens; Hoffmann Torsten; Heiser Ulrich; Demuth Hans Ulrich; Arck Petra C; Klapp Burghard F; Hildebrandt Martin
The expression of T-cell surface antigens CTLA-4, CD26, and CD28 is modulated by inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity in murine stress-induced abortions.
Cellular immunology 2002;220(2):150-6.
-
2002: Schulz Ingo; Gerhartz Bernd; Neubauer Antje; Holloschi Andreas; Heiser Ulrich; Hafner Mathias; Demuth Hans-Ulrich
Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition.
European journal of biochemistry / FEBS 2002;269(23):5813-20.
-
2002: Pospisilik John A; Stafford Sara G; Demuth Hans-Ulrich; McIntosh Christopher H S; Pederson Raymond A
Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study.
Diabetes 2002;51(9):2677-83.
-
2002: Schilling Stephan; Hoffmann Torsten; Rosche Fred; Manhart Susanne; Wasternack Claus; Demuth Hans-Ulrich
Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity.
Biochemistry 2002;41(35):10849-57.
-
2002: Demuth Hans-Ulrich; Hinke Simon A; Pederson Raymond A; McIntosh Christopher H S
Rebuttal to Deacon and Holst: "Metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1" versus "Dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective".
Biochemical and biophysical research communications 2002;296(2):229-32.
-
2002: Hinke Simon A; McIntosh Christopher H S; Hoffmann Torsten; Kühn-Wache Kerstin; Wagner Leona; Bär Joachim; Manhart Susanne; Wermann Michael; Pederson Raymond A; Demuth Hans-Ulrich
On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors.
Diabetes care 2002;25(8):1490-1; author reply 1491-2.
-
2002: Niestroj André J; Feussner Kirstin; Heiser Ulrich; Dando Pam M; Barrett Alan; Gerhartz Bernd; Demuth Hans-Ulrich
Inhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones.
Biological chemistry 2002;383(7-8):1205-14.
-
2002: Pospisilik J A; Stafford S G; Demuth H-U; Brownsey R; Parkhouse W; Finegood D T; McIntosh C H S; Pederson R A
Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats.
Diabetes 2002;51(4):943-50.
-
2002: Schilling Stephan; Hoffmann Torsten; Wermann Michael; Heiser Ulrich; Wasternack Claus; Demuth Hans-Ulrich
Continuous spectrometric assays for glutaminyl cyclase activity.
Analytical biochemistry 2002;303(1):49-56.
-
2002: Hinke Simon A; Kühn-Wache Kerstin; Hoffmann Torsten; Pederson Raymond A; McIntosh Christopher H S; Demuth Hans-Ulrich
Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1.
Biochemical and biophysical research communications 2002;291(5):1302-8.
-
2002: Hinke Simon A; Gelling Richard W; Pederson Raymond A; Manhart Susanne; Nian Cuilan; Demuth Hans-Ulrich; McIntosh Christopher H S
Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats.
Diabetes 2002;51(3):652-61.
-
2001: Korosi J; McIntosh C H; Pederson R A; Demuth H U; Habener J F; Gingerich R; Egan J M; Elahi D; Meneilly G S
Effect of aging and diabetes on the enteroinsular axis.
The journals of gerontology. Series A, Biological sciences and medical sciences 2001;56(9):M575-9.
-
2001: Wolf R; Rosche F; Hoffmann T; Demuth H U
Immunoprecipitation and liquid chromatographic-mass spectrometric determination of the peptide glucose-dependent insulinotropic polypeptides GIP1-42 and GIP3-42 from human plasma samples. New sensitive method to analyze physiological concentrations of peptide hormones.
Journal of chromatography. A 2001;926(1):21-7.
-
2001: Hinke S A; Manhart S; Pamir N; Demuth H; W Gelling R; Pederson R A; McIntosh C H
Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP).
Biochimica et biophysica acta 2001;1547(1):143-55.
-
2001: Pospisilik J A; Hinke S A; Pederson R A; Hoffmann T; Rosche F; Schlenzig D; Glund K; Heiser U; McIntosh C H; Demuth H
Metabolism of glucagon by dipeptidyl peptidase IV (CD26).
Regulatory peptides 2001;96(3):133-41.
-
2000: Meneilly G S; Demuth H U; McIntosh C H; Pederson R A
Effect of ageing and diabetes on glucose-dependent insulinotropic polypeptide and dipeptidyl peptidase IV responses to oral glucose.
Diabetic medicine : a journal of the British Diabetic Association 2000;17(5):346-50.
-
2000: Hinke S A; Pauly R P; Ehses J; Kerridge P; Demuth H U; McIntosh C H; Pederson R A
Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide.
The Journal of endocrinology 2000;165(2):281-91.
-
2000: Hinke S A; Pospisilik J A; Demuth H U; Mannhart S; Kühn-Wache K; Hoffmann T; Nishimura E; Pederson R A; McIntosh C H
Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs.
The Journal of biological chemistry 2000;275(6):3827-34.
-
2000: Rosche F; Schmidt J; Hoffmann T; Pauly R P; McIntosh C H; Pederson R A; Demuth H U
Kinetic analysis of enzymatic and nonenzymatic degradation of peptides by MALDI-TOFMS.
Methods in molecular biology (Clifton, N.J.) 2000;146():251-72.
-
2000: Kühn-Wache K; Manhart S; Hoffmann T; Hinke S A; Gelling R; Pederson R A; McIntosh C H; Demuth H U
Analogs of glucose-dependent insulinotropic polypeptide with increased dipeptidyl peptidase IV resistance.
Advances in experimental medicine and biology 2000;477():187-95.
-
1999: Pauly R P; Demuth H U; Rosche F; Schmidt J; White H A; Lynn F; McIntosh C H; Pederson R A
Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide.
Metabolism: clinical and experimental 1999;48(3):385-9.
-
1998: Pederson R A; White H A; Schlenzig D; Pauly R P; McIntosh C H; Demuth H U
Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide.
Diabetes 1998;47(8):1253-8.
-
1996: Vogel D; Schmidt R; Hartung K; Demuth H U; Chung N N; Schiller P W
Cyclic morphiceptin analogs: cyclization studies and opioid activities in vitro.
International journal of peptide and protein research 1996;48(6):495-502.
-
1996: Pauly R P; Rosche F; Wermann M; McIntosh C H; Pederson R A; Demuth H U
Investigation of glucose-dependent insulinotropic polypeptide-(1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. A novel kinetic approach.
The Journal of biological chemistry 1996;271(38):23222-9.
-
1996: Demuth H U; Schierhorn A; Bryan P; Höfke R; Kirschke H; Brömme D
N-peptidyl, O-acyl hydroxamates: comparison of the selective inhibition of serine and cysteine proteinases.
Biochimica et biophysica acta 1996;1295(2):179-86.
-
1996: Kaspari A; Diefenthal T; Grosche G; Schierhorn A; Demuth H U
Substrates containing phosphorylated residues adjacent to proline decrease the cleavage by proline-specific peptidases.
Biochimica et biophysica acta 1996;1293(1):147-53.
-
1994: Brömme D; Demuth H U
N,O-diacyl hydroxamates as selective and irreversible inhibitors of cysteine proteinases.
Methods in enzymology 1994;244():671-85.
-
1993: Hegen M; Mittrücker H W; Hug R; Demuth H U; Neubert K; Barth A; Fleischer B
Enzymatic activity of CD26 (dipeptidylpeptidase IV) is not required for its signalling function in T cells.
Immunobiology 1993;189(5):483-93.
-
1993: Silberring J; Demuth H U; Brostedt P; Nyberg F
Inhibition of dynorphin converting enzymes from human spinal cord by N-peptidyl-O-acyl hydroxylamines.
Journal of biochemistry 1993;114(5):648-51.
-
1993: Brömme D; Neumann U; Kirschke H; Demuth H U
Novel N-peptidyl-O-acyl hydroxamates: selective inhibitors of cysteine proteinases.
Biochimica et biophysica acta 1993;1202(2):271-6.
-
1993: Demuth H U; Stöckel A; Schierhorn A; Fittkau S; Kirschke H; Brömme D
Inhibition of aminopeptidases by N-aminoacyl-O-4-nitrobenzoyl hydroxamates.
Biochimica et biophysica acta 1993;1202(2):265-70.
-
1993: Demuth H U; Schlenzig D; Schierhorn A; Grosche G; Chapot-Chartier M P; Gripon J C
Design of (omega-N-(O-acyl)hydroxy amid) aminodicarboxylic acid pyrrolidides as potent inhibitors of proline-specific peptidases.
FEBS letters 1993;320(1):23-7.
-
1993: Steinmetzer T; Silberring J; Mrestani-Klaus C; Fittkau S; Barth A; Demuth H U
Peptidyl ammonium methyl ketones as substrate analog inhibitors of proline-specific peptidases.
Journal of enzyme inhibition 1993;7(2):77-85.
-
1992: Bakalkin Gya; Demuth H U; Nyberg F
Relationship between primary structure and activity in exorphins and endogenous opioid peptides.
FEBS letters 1992;310(1):13-6.
-
1991: Schön E; Born I; Demuth H U; Faust J; Neubert K; Steinmetzer T; Barth A; Ansorge S
Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes.
Biological chemistry Hoppe-Seyler 1991;372(5):305-11.
-
1991: Demuth H U; Nyberg F
Studies of specificity and inhibition of human cerebrospinal fluid dynorphin converting enzyme.
Journal of enzyme inhibition 1991;4(4):299-306.
-
1991: Neumann U; Steinmetzer T; Barth A; Demuth H U
Reaction of dipeptidylpeptidase IV with substrate-analogous azapeptides.
Journal of enzyme inhibition 1991;4(3):213-26.
-
1991: Demuth H U; Silberring J; Nyberg F
Inhibition of proteases with enkephalin-analogue inhibitors.
Journal of enzyme inhibition 1991;4(4):289-98.
-
1990: Demuth H U
Recent developments in inhibiting cysteine and serine proteases.
Journal of enzyme inhibition 1990;3(4):249-78.
-
1989: Brömme D; Schierhorn A; Kirschke H; Wiederanders B; Barth A; Fittkau S; Demuth H U
Potent and selective inactivation of cysteine proteinases with N-peptidyl-O-acyl hydroxylamines.
The Biochemical journal 1989;263(3):861-6.
-
1989: Demuth H U; Schönlein C; Barth A
Potent and selective inactivation of proteinases with N-peptidyl-O-acylhydroxylamines.
Biochimica et biophysica acta 1989;996(1-2):19-22.
-
1989: Schön E; Demuth H U; Eichmann E; Horst H J; Körner I J; Kopp J; Mattern T; Neubert K; Noll F; Ulmer A J
Dipeptidyl peptidase IV in human T lymphocytes. Impaired induction of interleukin 2 and gamma interferon due to specific inhibition of dipeptidyl peptidase IV.
Scandinavian journal of immunology 1989;29(2):127-32.
-
1989: Demuth H U; Neumann U; Barth A
Reactions between dipeptidyl peptidase IV and diacyl hydroxylamines: mechanistic investigations.
Journal of enzyme inhibition 1989;2(4):239-48.
-
1988: Lasch J; Koelsch R; Steinmetzer T; Neumann U; Demuth H U
Enzymic properties of intestinal aminopeptidase P: a new continuous assay.
FEBS letters 1988;227(2):171-4.
-
1987: Schön E; Jahn S; Kiessig S T; Demuth H U; Neubert K; Barth A; Von Baehr R; Ansorge S
The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and immunoglobulin synthesis in vitro.
European journal of immunology 1987;17(12):1821-6.
-
1986: Kaemmer D; Neubert K; Demuth H U; Barth A
Contamination of highly purified human serum cholinesterase by dipeptidyl peptidase IV causing hydrolysis of substance P.
Die Pharmazie 1986;41(7):494-6.
-
1985: Schön E; Mansfeld H W; Demuth H U; Barth A; Ansorge S
The dipeptidyl peptidase IV, a membrane enzyme involved in the proliferation of T lymphocytes.
Biomedica biochimica acta 1985;44(2):K9-15.
-
1984: Schön E; Demuth H U; Barth A; Ansorge S
Dipeptidyl peptidase IV of human lymphocytes. Evidence for specific hydrolysis of glycylproline p-nitroanilide in T-lymphocytes.
The Biochemical journal 1984;223(1):255-8.
Sign-in to see more
