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Ayumi Denda

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Takasumi Shimomoto; Naokuni Tatsumoto; Yi Luo; Hitoshi Ohmori; Tomonori Sasahira; Yoshitomo Chihara; Ayumi Denda; Kiyomu Fujii; Hiroki Kuniyasu
Diabetes-associated angiotensin activation enhances liver metastasis of colon cancer.
Takasumi Shimomoto; Yi Luo; Hitoshi Ohmori; Tomonori Sasahira; Yoshitomo Chihara; Ayumi Denda; Kiyomu Fujii; Hiroki Kuniyasu
Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet.
Hitoshi Ohmori; Yi Luo; Kiyomu Fujii; Tomonori Sasahira; Takasumi Shimomoto; Ayumi Denda; Hiroki Kuniyasu
Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1.

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2012: Takasumi Shimomoto; Naokuni Tatsumoto; Yi Luo; Hitoshi Ohmori; Tomonori Sasahira; Yoshitomo Chihara; Ayumi Denda; Kiyomu Fujii; Hiroki Kuniyasu
Diabetes-associated angiotensin activation enhances liver metastasis of colon cancer.
Clinical & experimental metastasis 2012;29(8):915-25.
2012: Takasumi Shimomoto; Yi Luo; Hitoshi Ohmori; Tomonori Sasahira; Yoshitomo Chihara; Ayumi Denda; Kiyomu Fujii; Hiroki Kuniyasu
Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet.
Journal of gastroenterology 2012;47(10):1073-83.
2010: Hitoshi Ohmori; Yi Luo; Kiyomu Fujii; Tomonori Sasahira; Takasumi Shimomoto; Ayumi Denda; Hiroki Kuniyasu
Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1.
Pathobiology : journal of immunopathology, molecular and cellular biology 2010;77(4):210-7.
2009: Kiyomu Fujii; Y Luo; Tomonori Sasahira; Ayumi Denda; Hitoshi Ohmori; Hiroki Kuniyasu
Co-treatment with deoxycholic acid and azoxymethane accelerates secretion of HMGB1 in IEC6 intestinal epithelial cells.
Cell proliferation 2009;42(5):701-9.
2007: Ayumi Denda; Wakashi Kitayama; Hideki Kishida; Nao Murata; Kazutoshi Tamura; Osamu Kusuoka; Masahiro Tsutsumi; Fumiko Nishikawa; Eiji Kita; Dai Nakae; Yoichi Konishi; Hiroki Kuniyasu
Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, L-amino acid-defined diet in rats and mice.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2007;16(1):164-76.
2006: Takamitsu Sasaki; Kazuhiro Yoshida; Hideo Shimura; Masayosi Ichiba; Tomonori Sasahira; Takasumi Shimomoto; Ayumi Denda; Hiroki Kuniyasu
Inhibitory effect of linoleic acid on transformation of IEC6 intestinal cells by in vitro azoxymethane treatment.
International journal of cancer. Journal international du cancer 2006;118(3):593-9.
2006: Kazuhiko Yamamoto; Wakashi Kitayama; Ayumi Denda; Tomonori Sasahira; Hiroki Kuniyasu; Tadaaki Kirita
Expression of receptor for advanced glycation end products during rat tongue carcinogenesis by 4-nitroquinoline 1-oxide and effect of a selective cyclooxygenase-2 inhibitor, etodolac.
Pathobiology : journal of immunopathology, molecular and cellular biology 2006;73(6):317-24.
2005: Christine L Powell; Oksana Kosyk; Blair U Bradford; Joel Parker; Edward K Lobenhofer; Ayumi Denda; Fumiyuki Uematsu; Dai Nakae; Ivan Rusyn
Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury.
Hepatology (Baltimore, Md.) 2005;42(5):1137-47.
2004: Kazuhiko Yamamoto; Wakashi Kitayama; Ayumi Denda; A Morisaki; Hiroki Kuniyasu; M Inoue; Tadaaki Kirita
Suppressive effects of a selective cyclooxygenase-2 inhibitor, etodolac, on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2004;56(3):145-51.
2004: Ken Higashi; Ayumi Denda; Taneaki Higashi; Hiroshi Hiai
Genetic resistance to chemical hepatocarcinogenesis in the DRH rat strain.
Comparative medicine 2004;54(4):373-7.
2004: Dai Nakae; Fumiyuki Uematsu; Hideki Kishida; Osamu Kusuoka; Shin-Ichi Katsuda; Midori Yoshida; Masakazu Takahashi; Akihiko Maekawa; Ayumi Denda; Yoichi Konishi; Yashige Kotake; Robert A Floyd
Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, L-amino acid-defined diet.
Cancer letters 2004;206(1):1-13.
2003: Kazuhiko Yamamoto; Wakashi Kitayama; Ayumi Denda; Ayumu Morisaki; Hiroki Kuniyasu; Tadaaki Kirita
Inhibitory effects of selective cyclooxygenase-2 inhibitors, nimesulide and etodolac, on the development of squamous cell dysplasias and carcinomas of the tongue in rats initiated with 4-nitroquinoline 1-oxide.
Cancer letters 2003;199(2):121-9.
2002: Rawiwan Puatanachokchai; Hideki Kishida; Ayumi Denda; Nao Murata; Yoichi Konishi; Usanee Vinitketkumnuen; Dai Nakae
Inhibitory effects of lemon grass (Cymbopogon citratus, Stapf) extract on the early phase of hepatocarcinogenesis after initiation with diethylnitrosamine in male Fischer 344 rats.
Cancer letters 2002;183(1):9-15.
2002: Ayumi Denda; Wakashi Kitayama; Akiko Murata; Hideki Kishida; Yasutaka Sasaki; Osamu Kusuoka; Toshifumi Tsujiuchi; Masahiro Tsutsumi; Dai Nakae; Hidetoshi Takagi; Yoichi Konishi
Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide.
Carcinogenesis 2002;23(2):245-56.
2002: Ayumi Denda; Wakashi Kitayama; Hideki Kishida; Nao Murata; Masahiro Tsutsumi; Toshifumi Tsujiuchi; Dai Nakae; Yoichi Konishi
Development of hepatocellular adenomas and carcinomas associated with fibrosis in C57BL/6J male mice given a choline-deficient, L-amino acid-defined diet.
Japanese journal of cancer research : Gann 2002;93(2):125-32.
2002: Ying Yan; Zhao-Zhu Zeng; Shin Higashi; Ayumi Denda; Yoichi Konishi; Shunzo Onishi; Hikaru Ueno; Ken Higashi; Hiroshi Hiai
Resistance of DRH strain rats to chemical carcinogenesis of liver: genetic analysis of later progression stage.
Carcinogenesis 2002;23(1):189-96.
2001: H Shiotani; Ayumi Denda; K Yamamoto; Wakashi Kitayama; T Endoh; Y Sasaki; N Tsutsumi; M Sugimura; Y Konishi
Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide.
Cancer research 2001;61(4):1451-6.
2001: Hiroki Kuniyasu; Naohide Oue; Dai Nakae; M Tsutsumi; Ayumi Denda; Toshifumi Tsujiuchi; Hiroshi Yokozaki; Wataru Yasui
Interleukin-15 expression is associated with malignant potential in colon cancer cells.
Pathobiology : journal of immunopathology, molecular and cellular biology 2001;69(2):86-95.
2000: Hideki Kishida; Dai Nakae; Y Kobayashi; Osamu Kusuoka; Wakashi Kitayama; Ayumi Denda; H Fukui; Yoichi Konishi
Enhancement of hepatocarcinogenesis initiated with diethylnitrosamine or N-nitrosobis(2-hydroxypropyl)amine by a choline-deficient, L-amino acid-defined diet administered prior to the carcinogen exposure in rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2000;52(5):405-12.
2000: Zhao-Zhu Zeng; Shin Higashi; Wakashi Kitayama; Ayumi Denda; Ying Yan; K Matsuo; Y Konishi; Hiroshi Hiai; Ken Higashi
Genetic resistance to chemical carcinogen-induced preneoplastic hepatic lesions in DRH strain rats.
Cancer research 2000;60(11):2876-81.
2000: Wakashi Kitayama; Ayumi Denda; J Yoshida; Yasutaka Sasaki; M Takahama; K Murakawa; Toshifumi Tsujiuchi; Masahiro Tsutsumi; Yoichi Konishi
Increased expression of cyclooxygenase-2 protein in rat lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine.
Cancer letters 2000;148(2):145-52.
1999: Wakashi Kitayama; Ayumi Denda; E Okajima; Toshifumi Tsujiuchi; Yoichi Konishi
Increased expression of cyclooxygenase-2 protein in rat urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.
Carcinogenesis 1999;20(12):2305-10.
1999: Ayumi Denda; Wakashi Kitayama; Yoichi Konishi; Ying Yan; Y Fukamachi; Masayoshi Miura; Sadao Gotoh; Kunio Ikemura; Tetsuya Abe; Toshiaki Higashi; Ken Higashi
Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats.
Cancer letters 1999;140(1-2):59-67.
1998: Dai Nakae; Ayumi Denda; Y Kobayashi; H Akai; Hideki Kishida; Toshifumi Tsujiuchi; Yoichi Konishi; T Suzuki; M Muramatsu
Inhibition of early-phase exogenous and endogenous liver carcinogenesis in transgenic rats harboring a rat glutathione S-transferase placental form gene.
Japanese journal of cancer research : Gann 1998;89(11):1118-25.
1998: Dai Nakae; Yashige Kotake; Hideki Kishida; Kenneth Hensley; Ayumi Denda; Y Kobayashi; Wakashi Kitayama; Toshifumi Tsujiuchi; Hong Sang; Charles A Stewart; Tahereh Tabatabaie; Robert A Floyd; Yoichi Konishi
Inhibition by phenyl N-tert-butyl nitrone of early phase carcinogenesis in the livers of rats fed a choline-deficient, L-amino acid-defined diet.
Cancer research 1998;58(20):4548-51.
1998: Y Kobayashi; Dai Nakae; H Akai; Hideki Kishida; E Okajima; Wakashi Kitayama; Ayumi Denda; Toshifumi Tsujiuchi; A Murakami; K Koshimizu; H Ohigashi; Yoichi Konishi
Prevention by 1'-acetoxychavicol acetate of the induction but not growth of putative preneoplastic, glutathione S-transferase placental form-positive, focal lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet.
Carcinogenesis 1998;19(10):1809-14.
1998: E Okajima; Ayumi Denda; S Ozono; M Takahama; H Akai; Yasutaka Sasaki; Wakashi Kitayama; K Wakabayashi; Yoichi Konishi
Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on the development of rat urinary bladder carcinomas initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Cancer research 1998;58(14):3028-31.
1998: Ayumi Denda; T Endoh; Q Tang; Toshifumi Tsujiuchi; Dai Nakae; Yoichi Konishi
Prevention by inhibitors of arachidonic acid cascade of liver carcinogenesis, cirrhosis and oxidative DNA damage caused by a choline-deficient, L-amino acid-defined diet in rats.
Mutation research 1998;402(1-2):279-88.
1998: Toshifumi Tsujiuchi; Masahiro Tsutsumi; Akira Kido; M Takahama; H Sakitani; K Iki; Yasutaka Sasaki; Ayumi Denda; Yoichi Konishi
Induction of telomerase activity during regeneration after partial hepatectomy in the rat.
Cancer letters 1998;122(1-2):115-20.
1998: E Okajima; Masahiro Tsutsumi; S Ozono; H Akai; Ayumi Denda; H Nishino; S Oshima; H Sakamoto; Yoichi Konishi
Inhibitory effect of tomato juice on rat urinary bladder carcinogenesis after N-butyl-N-(4-hydroxybutyl)nitrosamine initiation.
Japanese journal of cancer research : Gann 1998;89(1):22-6.
1997: K Tamura; Dai Nakae; K Horiguchi; H Akai; Y Kobayashi; N Andoh; H Satoh; Ayumi Denda; Toshifumi Tsujiuchi; H Yoshiji; Yoichi Konishi
Inhibition by N-(4-hydroxyphenyl)retinamide and all-trans-retinoic acid of exogenous and endogenous development of putative preneoplastic, glutathione S-transferase placental form-positive lesions in the livers of rats.
Carcinogenesis 1997;18(11):2133-41.
1997: Ayumi Denda; T Endoh; Wakashi Kitayama; Q Tang; O Noguchi; Y Kobayashi; H Akai; E Okajima; Toshifumi Tsujiuchi; Masahiro Tsutsumi; Dai Nakae; Yoichi Konishi
Inhibition by piroxicam of oxidative DNA damage, liver cirrhosis and development of enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats.
Carcinogenesis 1997;18(10):1921-30.
1997: E Okajima; S Ozono; T Endo; T Majima; Masahiro Tsutsumi; T Fukuda; H Akai; Ayumi Denda; Y Hirao; E Okajima; H Nishino; Z Nir; Yoichi Konishi
Chemopreventive efficacy of piroxicam administered alone or in combination with lycopene and beta-carotene on the development of rat urinary bladder carcinoma after N-butyl-N-(4-hydroxybutyl)nitrosamine treatment.
Japanese journal of cancer research : Gann 1997;88(6):543-52.
1997: K Tamura; Dai Nakae; K Horiguchi; H Akai; Y Kobayashi; H Satoh; Toshifumi Tsujiuchi; Ayumi Denda; Yoichi Konishi
Inhibition by green tea extract of diethylnitrosamine-initiated but not choline-deficient, L-amino acid-defined diet-associated development of putative preneoplastic, glutathione S-transferase placental form-positive lesions in rat liver.
Japanese journal of cancer research : Gann 1997;88(4):356-62.
1997: Y Murata; Ayumi Denda; H Maruyama; Dai Nakae; M Tsutsumi; Toshifumi Tsujiuchi; Y Konishi
Chronic toxicity and carcinogenicity studies of 2-methylnaphthalene in B6C3F1 mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1997;36(1):90-3.
1996: Toshifumi Tsujiuchi; Akira Kido; Dai Nakae; M Takahama; T Majima; K Kobitsu; E Okajima; Masahiro Tsutsumi; Ayumi Denda; Yoichi Konishi
Infrequent Ki-ras and an absence of p53 mutations in hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats.
Cancer letters 1996;108(1):137-41.
1996: Toshifumi Tsujiuchi; Masahiro Tsutsumi; Akira Kido; K Kobitsu; M Takahama; T Majima; Ayumi Denda; Dai Nakae; Yoichi Konishi
Increased telomerase activity in hyperplastic nodules and hepatocellular carcinomas induced by a choline-deficient L-amino acid-defined diet in rats.
Japanese journal of cancer research : Gann 1996;87(11):1111-5.
1996: E Kobayashi; Toshifumi Tsujiuchi; Dai Nakae; Y Mizumoto; N Andoh; T Endoh; H Kitada; Masahiro Tsutsumi; Ayumi Denda; Yoichi Konishi
Inhibitory effects of N,N'-diphenyl-p-phenylenediamine on the early stage of the enhanced hepatocarcinogenesis caused by coadministration of ethionine and a choline-deficient L-amino acid-defined diet in rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1996;48(4):275-82.
1996: T Endoh; Q Tang; Ayumi Denda; O Noguchi; E Kobayashi; K Tamura; K Horiguchi; H Ogasawara; Toshifumi Tsujiuchi; Dai Nakae; M Sugimura; Yoichi Konishi
Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats.
Carcinogenesis 1996;17(3):467-75.
1996: amedeo columbano; T Endoh; Ayumi Denda; O Noguchi; Dai Nakae; K Hasegawa; Giovanna M Ledda-Columbano; A I Zedda; Yoichi Konishi
Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis.
Carcinogenesis 1996;17(3):395-400.
1995: Ayumi Denda; T Endoh; Dai Nakae; Yoichi Konishi
Effects of oxidative stress induced by redox-enzyme modulation on rat hepatocarcinogenesis.
Toxicology letters 1995;82-83():413-7.
1995: K Yamamoto; Masahiro Tsutsumi; E Kobayashi; T Endoh; O Noguchi; E Okajima; Ayumi Denda; Y Mori; Yoichi Konishi
Initiation of hepatocarcinogenesis by endogenously formed N-nitrosobis(2-hydroxypropyl)amine, N-nitrosodiethanolamine and N-nitroso-2,6-dimethylmorpholine in rats.
Carcinogenesis 1995;16(11):2633-6.
1995: Dai Nakae; Y Mizumoto; N Andoh; K Tamura; K Horiguchi; T Endoh; E Kobayashi; Toshifumi Tsujiuchi; Ayumi Denda; B Lombardi
Comparative changes in the liver of female Fischer-344 rats after short-term feeding of a semipurified or a semisynthetic L-amino acid-defined choline-deficient diet.
Toxicologic pathology 1995;23(5):583-90.
1995: Masahiro Tsutsumi; O Noguchi; S Okita; K Horiguchi; E Kobayashi; K Tamura; Toshifumi Tsujiuchi; Ayumi Denda; Yoichi Konishi; K Iimura
Inhibitory effects of sulfation inhibitors on initiation of pancreatic ductal carcinogenesis by N-nitrosobis(2-oxopropyl)amine in hamsters.
Carcinogenesis 1995;16(3):457-9.
1994: Dai Nakae; N Andoh; Y Mizumoto; T Endoh; N Shimoji; K Horiguchi; K Shiraiwa; K Tamura; Ayumi Denda; Yoichi Konishi
Selective 8-hydroxyguanine formation in pancreatic DNA due to a single intravenous administration of 4-hydroxyaminoquinoline 1-oxide in rats.
Cancer letters 1994;83(1-2):97-103.
1994: Toshifumi Tsujiuchi; Masahiro Tsutsumi; Kanya Honoki; K Horiguchi; E Kobayashi; Ayumi Denda; Yoichi Konishi
Effects of novobiocin on the induction of gamma-glutamyltranspeptidase positive foci in the liver of rats treated with diethylnitrosamine.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1994;46(2):115-8.
1994: Ayumi Denda; Q Tang; T Endoh; Toshifumi Tsujiuchi; K Horiguchi; O Noguchi; Y Mizumoto; Dai Nakae; Yoichi Konishi
Prevention by acetylsalicylic acid of liver cirrhosis and carcinogenesis as well as generations of 8-hydroxydeoxyguanosine and thiobarbituric acid-reactive substances caused by a choline-deficient, L-amino acid-defined diet in rats.
Carcinogenesis 1994;15(6):1279-83.
1994: H Maruyama; T Amanuma; Masahiro Tsutsumi; Toshifumi Tsujiuchi; K Horiguchi; Ayumi Denda; Yoichi Konishi
Inhibition by catechol and di(2-ethylhexyl)phthalate of pancreatic carcinogenesis after initiation with N-nitrosobis(2-hydroxypropyl)amine in Syrian hamsters.
Carcinogenesis 1994;15(6):1193-6.
1994: Y Mizumoto; Dai Nakae; Hitoshi Yoshiji; N Andoh; K Horiguchi; T Endoh; E Kobayashi; Toshifumi Tsujiuchi; N Shimoji; Ayumi Denda
Inhibitory effects of 2-O-octadecylascorbic acid and other vitamin C and E derivatives on the induction of enzyme-altered putative preneoplastic lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet.
Carcinogenesis 1994;15(2):241-6.
1993: Y Murata; Ayumi Denda; H Maruyama; Yoichi Konishi
Chronic toxicity and carcinogenicity studies of 1-methylnaphthalene in B6C3F1 mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;21(1):44-51.
1993: Q Tang; Ayumi Denda; Toshifumi Tsujiuchi; Masahiro Tsutsumi; T Amanuma; Y Murata; H Maruyama; Yoichi Konishi
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.
Japanese journal of cancer research : Gann 1993;84(2):120-7.
1993: Ayumi Denda; Q Tang; Toshifumi Tsujiuchi; Masahiro Tsutsumi; T Amanuma; Y Murata; K Tamura; K Horiguchi; Dai Nakae; Yoichi Konishi
Effects of oxidative stress induced by redox-enzyme modulation on the progression stage of rat hepatocarcinogenesis.
Carcinogenesis 1993;14(1):95-101.
1992: Dai Nakae; Hitoshi Yoshiji; Y Mizumoto; K Horiguchi; K Shiraiwa; K Tamura; Ayumi Denda; Yoichi Konishi
High incidence of hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats.
Cancer research 1992;52(18):5042-5.
1992: Toshifumi Tsujiuchi; Masahiro Tsutsumi; K Uchida; Kanya Honoki; S Kondoh; Ayumi Denda; M Miwa; Yoichi Konishi
Delayed DNA synthesis induced by 3-aminobenzamide in partially hepatectomized liver of rats.
Japanese journal of cancer research : Gann 1992;83(9):985-8.
1992: H Maruyama; T Amanuma; Y Takashima; Hitoshi Yoshiji; Dai Nakae; Masahiro Tsutsumi; Toshifumi Tsujiuchi; Ayumi Denda; Yoichi Konishi
Possible enhancing effect of the immunosuppressive agent, 6-mercaptopurine(6-MP) on focal lesion development in cirrhotic liver induced by carbon tetrachloride but not furfural in F344 rats.
Carcinogenesis 1992;13(8):1365-9.
1992: Hitoshi Yoshiji; Dai Nakae; Y Mizumoto; K Horiguchi; K Tamura; Ayumi Denda; T Tsujii; Yoichi Konishi
Inhibitory effect of dietary iron deficiency on inductions of putative preneoplastic lesions as well as 8-hydroxydeoxyguanosine in DNA and lipid peroxidation in the livers of rats caused by exposure to a choline-deficient L-amino acid defined diet.
Carcinogenesis 1992;13(7):1227-33.
1992: T Amanuma; H Maruyama; Toshifumi Tsujiuchi; Masahiro Tsutsumi; Ayumi Denda; Yoichi Konishi
Lack of modifying effects of 6-mercaptopurine in a medium term bioassay system for liver carcinogenesis using male F344 rats.
Cancer letters 1992;64(2):99-107.
1992: Yoichi Konishi; Ayumi Denda; K Uchida; Y Emi; H Ura; Y Yokose; K Shiraiwa; Masahiro Tsutsumi
Chronic toxicity carcinogenicity studies of triethanolamine in B6C3F1 mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1992;18(1):25-9.
1991: Toshifumi Tsujiuchi; K Mizumoto; Masahiro Tsutsumi; Ayumi Denda; T Amanuma; S Kondoh; Yoichi Konishi
Effects of 3-aminobenzamide on the post-initiation phase of N-nitrosobis(2-oxopropyl)amine induced pancreatic carcinogenesis in Syrian hamsters.
Cancer letters 1991;61(1):61-6.
1991: Hitoshi Yoshiji; Dai Nakae; T Kinugasa; M Matsuzaki; Ayumi Denda; T Tsujii; Yoichi Konishi
Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital.
British journal of cancer 1991;64(5):839-42.
1991: H Maruyama; T Amanuma; Dai Nakae; Masahiro Tsutsumi; S Kondo; Toshifumi Tsujiuchi; Ayumi Denda; Yoichi Konishi
Effects of catechol and its analogs on pancreatic carcinogenesis initiated by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters.
Carcinogenesis 1991;12(7):1331-4.
1991: Toshifumi Tsujiuchi; Masahiro Tsutsumi; Ayumi Denda; T Amanuma; S Kondoh; K Kamino; Yoichi Konishi
Effects of 3-aminobenzamide on induction of multiorgan carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine in hamsters.
Japanese journal of cancer research : Gann 1991;82(7):793-9.
1991: T Amanuma; K Mizumoto; Masahiro Tsutsumi; Toshifumi Tsujiuchi; S Kitazawa; K Hasegawa; Ayumi Denda; H Maruyama; Yoichi Konishi
Initiating activity of diethylnitrosamine in a rapid production model for pancreatic carcinomas in Syrian hamsters.
Japanese journal of cancer research : Gann 1991;82(6):632-7.
1991: Ayumi Denda; K M Sai; Q Tang; Toshifumi Tsujiuchi; Masahiro Tsutsumi; T Amanuma; Y Murata; Dai Nakae; H Maruyama; Y Kurokawa
Induction of 8-hydroxydeoxyguanosine but not initiation of carcinogenesis by redox enzyme modulations with or without menadione in rat liver.
Carcinogenesis 1991;12(4):719-26.
1990: Dai Nakae; Hitoshi Yoshiji; H Maruyama; T Kinugasa; Ayumi Denda; Yoichi Konishi
Production of both 8-hydroxydeoxyguanosine in liver DNA and gamma-glutamyltransferase-positive hepatocellular lesions in rats given a choline-deficient, L-amino acid-defined diet.
Japanese journal of cancer research : Gann 1990;81(11):1081-4.
1990: Toshifumi Tsujiuchi; Masahiro Tsutsumi; Ayumi Denda; S Kondoh; Dai Nakae; H Maruyama; Yoichi Konishi
Possible involvement of poly ADP-ribosylation in phenobarbital promotion of rat hepatocarcinogenesis.
Carcinogenesis 1990;11(10):1783-7.
1990: Dai Nakae; Hitoshi Yoshiji; K Yamamoto; H Maruyama; T Kinugasa; Y Takashima; Ayumi Denda; Yoichi Konishi
Influence of timing of administration of liposome-encapsulated superoxide dismutase on its prevention of acetaminophen-induced liver cell necrosis in rats.
Acta pathologica japonica 1990;40(8):568-73.
1990: S Kitazawa; Ayumi Denda; Masahiro Tsutsumi; Toshifumi Tsujiuchi; K Hasegawa; K Tamura; H Maruyama; Yoichi Konishi
Enhanced preneoplastic liver lesion development under 'selection pressure' conditions after administration of deoxycholic or lithocholic acid in the initiation phase in rats.
Carcinogenesis 1990;11(8):1323-8.
1990: H Maruyama; Y Takashima; Y Murata; Dai Nakae; H Eimoto; Masahiro Tsutsumi; Ayumi Denda; Yoichi Konishi
Lack of hepatocarcinogenic potential of acetaminophen in rats with liver damage associated with a choline-devoid diet.
Carcinogenesis 1990;11(6):895-901.
1990: K Mizumoto; Masahiro Tsutsumi; S Kitazawa; Ayumi Denda; Yoichi Konishi
Usefulness of rapid production model for pancreatic carcinoma in male hamsters.
Cancer letters 1990;49(3):211-5.
1989: Ayumi Denda; H Ura; Toshifumi Tsujiuchi; Masahiro Tsutsumi; H Eimoto; Y Takashima; S Kitazawa; T Kinugasa; Yoichi Konishi
Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis.
Carcinogenesis 1989;10(10):1929-35.
1989: K Yamamoto; A Nakajima; H Eimoto; Masahiro Tsutsumi; H Maruyama; Ayumi Denda; H Nii; Y Mori; Yoichi Konishi
Carcinogenic activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine in rats administered bis(2-hydroxypropyl)amine and sodium nitrite.
Carcinogenesis 1989;10(9):1607-11.
1989: K Mizumoto; S Ito; S Kitazawa; Masahiro Tsutsumi; Ayumi Denda; Yoichi Konishi
Inhibitory effect of butylated hydroxyanisole administration on pancreatic carcinogenesis in Syrian hamsters initiated with N-nitrosobis(2-oxopropyl)amine.
Carcinogenesis 1989;10(8):1491-4.
1989: K Mizumoto; S Kitazawa; S Ito; Y Takashima; Masahiro Tsutsumi; Ayumi Denda; Yoichi Konishi
Cycles of repeated augmentation pressure in rapid production of pancreatic and cholangiocellular carcinomas in hamsters initiated with N-nitrosobis(2-oxopropyl)amine.
Carcinogenesis 1989;10(8):1457-9.
1989: K Yamamoto; H Eimoto; Y Takashima; Masahiro Tsutsumi; H Maruyama; Ayumi Denda; Y Mori; Yoichi Konishi
Initiation activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine in the rat liver.
Cancer letters 1989;45(3):221-5.
1989: Ayumi Denda; Masahiro Tsutsumi; Toshifumi Tsujiuchi; H Eimoto; Yoichi Konishi; S Sato
Induction of rat liver gamma-glutamyltranspeptidase-positive foci by oral administration of 1-nitropyrene.
Cancer letters 1989;45(1):21-6.
1988: K Mizumoto; Masahiro Tsutsumi; Ayumi Denda; Yoichi Konishi
Rapid production of pancreatic carcinoma by initiation with N-nitroso-bis(2-oxopropyl)amine and repeated augmentation pressure in hamsters.
Journal of the National Cancer Institute 1988;80(19):1564-7.
1988: Ayumi Denda; Masahiro Tsutsumi; Y Yokose; H Eimoto; Yoichi Konishi
Effects of 3-aminobenzamide on the induction of gamma-glutamyl-transpeptidase-positive foci by various chemicals in rat liver.
Cancer letters 1988;39(1):29-36.
1987: H Ura; Ayumi Denda; Y Yokose; Masahiro Tsutsumi; Yoichi Konishi
Effect of vitamin E on the induction and evolution of enzyme-altered foci in the liver of rats treated with diethylnitrosamine.
Carcinogenesis 1987;8(11):1595-600.
1987: S Takahashi; Masahiro Tsutsumi; Dai Nakae; Ayumi Denda; T Kinugasa; Yoichi Konishi
Persistent effect of a low dose of preadministered diethylnitrosamine on the induction of enzyme-altered foci in rat liver.
Carcinogenesis 1987;8(4):509-13.
1987: H Ura; Y Yokose; K Mizumoto; A Nakajima; K Yamamoto; Ayumi Denda; Yoichi Konishi
Induction of gamma-glutamyltranspeptidase-positive foci in rat liver by deoxycholic acid.
Japanese journal of cancer research : Gann 1987;78(3):216-8.
1987: Yoichi Konishi; Y Yokose; Y Mori; H Yamazaki; K Yamamoto; A Nakajima; Ayumi Denda
Lung carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine-related compounds and their formation in rats.
IARC scientific publications 1987;(84):250-2.
1987: Y Murata; Ayumi Denda; T Obara; Y Yokose; Yoichi Konishi
Histochemical studies on gamma-glutamyltranspeptidase activity of pancreatic acinar cell lesions induced by 4-hydroxyaminoquinoline 1-oxide and/or azaserine in rats.
Experimental pathology 1987;32(1):41-53.
1986: Y Mori; H Yamazaki; K Toyoshi; Ayumi Denda; Y Konishi
Mutagenic activation of carcinogenic N-nitrosopropylamines by liver S9 fractions from mice, rats and hamsters: evidence for a cytochrome P-450-dependent reaction.
Carcinogenesis 1986;7(3):375-9.
1986: Yoichi Konishi; S Takahashi; Dai Nakae; K Uchida; Masahiro Tsutsumi; K Shiraiwa; Ayumi Denda
Possible model of liver carcinogenesis using inhibitors of NAD+ ADP ribosyl transferase in rats.
Toxicologic pathology 1986;14(4):483-8.
1985: Ayumi Denda; Y Mori; Y Yokose; K Uchida; Y Murata; T Makino; Masahiro Tsutsumi; Y Konishi
4-Hydroxyaminoquinoline 1-oxide metabolism and DNA adducts in the early stage of tumorigenesis in rats: comparison of target organ pancreas with non-target organ liver.
Chemico-biological interactions 1985;56(2-3):125-43.
1984: S Takahashi; Dai Nakae; Y Yokose; Y Emi; Ayumi Denda; S Mikami; T Ohnishi; Y Konishi
Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD+ ADP ribosyl transferase in rats.
Carcinogenesis 1984;5(7):901-6.
1984: T Obara; Ayumi Denda; Y Murata; T Makino; Y Yokose; M Katsuragi; Y Konishi; N Ueda; M Namiki
Enzyme histochemical studies on transplantable pancreatic adenocarcinomas in Syrian golden hamsters.
Experimental pathology 1984;26(4):205-11.
1983: Y Mori; T Niwa; H Takahashi; K Toyoshi; Ayumi Denda; S Takahashi; Y Konishi
Mutagenicity of N-nitrosobis(2-hydroxypropyl)amine and its related compounds in the presence of rat lung and liver S9.
Cancer letters 1983;18(3):271-5.
1983: Ayumi Denda; Y Yokose; Y Emi; Y Murata; T Ohara; M Sunagawa; S Mikami; S Takahashi; Y Konishi
Effects of caffeine on pancreatic tumorigenesis by 4-hydroxyaminoquinoline 1-oxide in partially pancreatectomized rats.
Carcinogenesis 1983;4(1):17-22.
1982: Y Konishi; Ayumi Denda; S Takahashi; H Maruyama; Y Yokose; Y Mori; M Matsui; K Toyoshi
Organotropic effect of N-nitroso-bis-(2-hydroxypropyl)-amine: production of lung adenocarcinoma in rats by a single intraperitoneal injection.
IARC scientific publications 1982;(41):611-8.
1980: Y Mori; K Toyoshi; Ayumi Denda; Y Konishi
[Synthesis of high specific activity 4-hydroxyaminoquinoline 1-oxide[6-3H].
Radioisotopes 1980;29(11):539-41.