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Mitsuhiro Denda

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Moe Tsutsumi; Sumiko Denda; Junichi Kumamoto; Masashi Nakatani; Mitsuhiro Denda
In vitro formation of organized structure between keratinocytes and dorsal-root-ganglion cells.
Sumiko Denda; Makiko Goto; Junichi Kumamoto; Kentaro Takei; Moe Tsutsumi; Mitsuhiro Denda
Oxytocin is expressed in epidermal keratinocytes and released upon stimulation with adenosine 5'-[γ-thio]triphosphate in vitro.
Kenneth R Feingold; Mitsuhiro Denda
Regulation of permeability barrier homeostasis.

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All Publications

2012: Moe Tsutsumi; Sumiko Denda; Junichi Kumamoto; Masashi Nakatani; Mitsuhiro Denda
In vitro formation of organized structure between keratinocytes and dorsal-root-ganglion cells.
Experimental dermatology 2012;21(11):886-8.
2012: Sumiko Denda; Makiko Goto; Junichi Kumamoto; Kentaro Takei; Moe Tsutsumi; Mitsuhiro Denda
Oxytocin is expressed in epidermal keratinocytes and released upon stimulation with adenosine 5'-[γ-thio]triphosphate in vitro.
Experimental dermatology 2012;21(7):535-7.
2012: Kenneth R Feingold; Mitsuhiro Denda
Regulation of permeability barrier homeostasis.
Clinics in dermatology 2012;30(3):263-8.
2011: Mitsuhiro Denda
Effects of topical application of aqueous solutions of hexoses on epidermal permeability barrier recovery rate after barrier disruption.
Experimental dermatology 2011;20(11):943-4.
2011: Makiko Goto; Kazuyuki Ikeyama; Moe Tsutsumi; Sumiko Denda; Mitsuhiro Denda
Phosphodiesterase inhibitors block the acceleration of skin permeability barrier repair by red light.
Experimental dermatology 2011;20(7):568-71.
2010: Makiko Goto; Kazuyuki Ikeyama; Moe Tsutsumi; Sumiko Denda; Mitsuhiro Denda
Calcium ion propagation in cultured keratinocytes and other cells in skin in response to hydraulic pressure stimulation.
Journal of cellular physiology 2010;224(1):229-33.
2010: Moe Tsutsumi; Sumiko Denda; Kazuyuki Ikeyama; Makiko Goto; Mitsuhiro Denda
Exposure to low temperature induces elevation of intracellular calcium in cultured human keratinocytes.
The Journal of investigative dermatology 2010;130(7):1945-8.
2010: Moe Tsutsumi; Hiroyuki Kitahata; Satoshi Nakata; Yumi Sanno; Masaharu Nagayama; Mitsuhiro Denda
Mathematical analysis of intercellular calcium propagation induced by adenosine triphosphate.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2010;16(2):146-50.
2010: Kazuyuki Ikeyama; Sumiko Denda; Moe Tsutsumi; Mitsuhiro Denda
Neuronal nitric oxide synthase in epidermis is involved in cutaneous circulatory response to mechanical stimulation.
The Journal of investigative dermatology 2010;130(4):1158-66.
2010: Sumiko Denda; Mitsuhiro Denda; Kaori Inoue; Toshihiko Hibino
Glycolic acid induces keratinocyte proliferation in a skin equivalent model via TRPV1 activation.
Journal of dermatological science 2010;57(2):108-13.
2009: Moe Tsutsumi; Kazuyuki Ikeyama; Sumiko Denda; Jotaro Nakanishi; Shigeyoshi Fuziwara; Hirofumi Aoki; Mitsuhiro Denda
Expressions of rod and cone photoreceptor-like proteins in human epidermis.
Experimental dermatology 2009;18(6):567-70.
2008: Eriko Kawai; Jotaro Nakanishi; Noriyuki Kumazawa; Koichiro Ozawa; Mitsuhiro Denda
Skin surface electric potential as an indicator of skin condition: a new, non-invasive method to evaluate epidermal condition.
Experimental dermatology 2008;17(8):688-92.
2007: Mitsuhiro Denda; M Tsutsumi; K Inoue; Debra Crumrine; K R Feingold; P M Elias
Potassium channel openers accelerate epidermal barrier recovery.
The British journal of dermatology 2007;157(5):888-93.
2007: M Tsutsumi; Mitsuhiro Denda
Paradoxical effects of beta-estradiol on epidermal permeability barrier homeostasis.
The British journal of dermatology 2007;157(4):776-9.
2007: Kazuyuki Ikeyama; Shigeyoshi Fuziwara; Mitsuhiro Denda
Topical application of neuronal nitric oxide synthase inhibitor accelerates cutaneous barrier recovery and prevents epidermal hyperplasia induced by barrier disruption.
The Journal of investigative dermatology 2007;127(7):1713-9.
2007: Mitsuhiro Denda; Sumiko Denda
Air-exposed keratinocytes exhibited intracellular calcium oscillation.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2007;13(2):195-201.
2007: Mitsuhiro Denda; Masashi Nakatani; Kazuyuki Ikeyama; Moe Tsutsumi; Sumiko Denda
Epidermal keratinocytes as the forefront of the sensory system.
Experimental dermatology 2007;16(3):157-61.
2007: Mitsuhiro Denda; Takaaki Sokabe; Tomoko Fukumi-Tominaga; Makoto Tominaga
Effects of skin surface temperature on epidermal permeability barrier homeostasis.
The Journal of investigative dermatology 2007;127(3):654-9.
2007: Kaori Inoue; Junichi Hosoi; Mitsuhiro Denda
Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes.
The Journal of investigative dermatology 2007;127(2):362-71.
2006: Mitsuhiro Denda; Shigeyoshi Fujiwara; Toshihiko Hibino
Expression of voltage-gated calcium channel subunit alpha1C in epidermal keratinocytes and effects of agonist and antagonists of the channel on skin barrier homeostasis.
Experimental dermatology 2006;15(6):455-60.
2005: Shigeyoshi Fuziwara; Ayako Suzuki; Kaori Inoue; Mitsuhiro Denda
Dopamine D2-like receptor agonists accelerate barrier repair and inhibit the epidermal hyperplasia induced by barrier disruption.
The Journal of investigative dermatology 2005;125(4):783-9.
2005: Yuji Katsuta; Toshii Iida; Shinji Inomata; Mitsuhiro Denda
Unsaturated fatty acids induce calcium influx into keratinocytes and cause abnormal differentiation of epidermis.
The Journal of investigative dermatology 2005;124(5):1008-13.
2005: Mitsuhiro Denda; K Nakanishi; Noriyuki Kumazawa
Topical application of ionic polymers affects skin permeability barrier homeostasis.
Skin pharmacology and physiology 2005;18(1):36-41.
2004: Shigeyoshi Fuziwara; K Ogawa; D Aso; D Yoshizawa; S Takata; Mitsuhiro Denda
Barium sulphate with a negative zeta potential accelerates skin permeability barrier recovery and prevents epidermal hyperplasia induced by barrier disruption.
The British journal of dermatology 2004;151(3):557-64.
2004: Mitsuhiro Denda; Shigeyoshi Fuziwara; Kaori Inoue
Association of cyclic adenosine monophosphate with permeability barrier homeostasis of murine skin.
The Journal of investigative dermatology 2004;122(1):140-6.
2003: Mitsuhiro Denda; Akiko Tomitaka; Hirohiko Akamatsu; Kayoko Matsunaga
Altered distribution of calcium in facial epidermis of aged adults.
The Journal of investigative dermatology 2003;121(6):1557-8.
2003: Y Ashida; Mitsuhiro Denda
Dry environment increases mast cell number and histamine content in dermis in hairless mice.
The British journal of dermatology 2003;149(2):240-7.
2003: Mitsuhiro Denda; Shigeyoshi Fuziwara; Kaori Inoue
Influx of calcium and chloride ions into epidermal keratinocytes regulates exocytosis of epidermal lamellar bodies and skin permeability barrier homeostasis.
The Journal of investigative dermatology 2003;121(2):362-7.
2003: Mitsuhiro Denda; Shigeyoshi Fuziwara; Kaori Inoue
Beta2-adrenergic receptor antagonist accelerates skin barrier recovery and reduces epidermal hyperplasia induced by barrier disruption.
The Journal of investigative dermatology 2003;121(1):142-8.
2003: Shigeyoshi Fuziwara; Kaori Inoue; Mitsuhiro Denda
NMDA-type glutamate receptor is associated with cutaneous barrier homeostasis.
The Journal of investigative dermatology 2003;120(6):1023-9.
2003: Chika Katagiri; Junko Sato; Junko Nomura; Mitsuhiro Denda
Changes in environmental humidity affect the water-holding property of the stratum corneum and its free amino acid content, and the expression of filaggrin in the epidermis of hairless mice.
Journal of dermatological science 2003;31(1):29-35.
2002: Mitsuhiro Denda
New strategies to improve skin barrier homeostasis.
Advanced drug delivery reviews 2002;54 Suppl 1():S123-30.
2002: Peter M Elias; Sung K Ahn; Mitsuhiro Denda; Barbara E Brown; Debra Crumrine; Llewellyn K Kimutai; László G Kömüves; Seung H Lee; Kenneth R Feingold
Modulations in epidermal calcium regulate the expression of differentiation-specific markers.
The Journal of investigative dermatology 2002;119(5):1128-36.
2002: Mitsuhiro Denda; Kaori Inoue; Shinji Inomata; Sumiko Denda
gamma-Aminobutyric acid (A) receptor agonists accelerate cutaneous barrier recovery and prevent epidermal hyperplasia induced by barrier disruption.
The Journal of investigative dermatology 2002;119(5):1041-7.
2002: Mitsuhiro Denda; Kaori Inoue; Shigeyoshi Fuziwara; Sumiko Denda
P2X purinergic receptor antagonist accelerates skin barrier repair and prevents epidermal hyperplasia induced by skin barrier disruption.
The Journal of investigative dermatology 2002;119(5):1034-40.
2002: Junko Sato; Mitsuhiro Denda; Sandra Chang; Peter M Elias; Kenneth R Feingold
Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis.
The Journal of investigative dermatology 2002;119(4):900-4.
2002: Kaori Inoue; Schuichi Koizumi; Shigeyoshi Fuziwara; Sumiko Denda; Kazuhide Inoue; Mitsuhiro Denda
Functional vanilloid receptors in cultured normal human epidermal keratinocytes.
Biochemical and biophysical research communications 2002;291(1):124-9.
2002: Mitsuhiro Denda; Noriyuki Kumazawa
Negative electric potential induces alteration of ion gradient and lamellar body secretion in the epidermis, and accelerates skin barrier recovery after barrier disruption.
The Journal of investigative dermatology 2002;118(1):65-72.
2001: J Sato; Chika Katagiri; J Nomura; Mitsuhiro Denda
Drastic decrease in environmental humidity decreases water-holding capacity and free amino acid content of the stratum corneum.
Archives of dermatological research 2001;293(9):477-80.
2001: Mitsuhiro Denda; Shigeyoshi Fuziwara; K Inoue; Sumiko Denda; H Akamatsu; A Tomitaka; K Matsunaga
Immunoreactivity of VR1 on epidermal keratinocyte of human skin.
Biochemical and biophysical research communications 2001;285(5):1250-2.
2001: Mitsuhiro Denda
Epidermal proliferative response induced by sodium dodecyl sulphate varies with environmental humidity.
The British journal of dermatology 2001;145(2):252-7.
2001: Mitsuhiro Denda; Y Ashida; K Inoue; Noriyuki Kumazawa
Skin surface electric potential induced by ion-flux through epidermal cell layers.
Biochemical and biophysical research communications 2001;284(1):112-7.
2001: Y Ashida; M Ogo; Mitsuhiro Denda
Epidermal interleukin-1 alpha generation is amplified at low humidity: implications for the pathogenesis of inflammatory dermatoses.
The British journal of dermatology 2001;144(2):238-43.
2001: Y Ashida; Mitsuhiro Denda; T Hirao
Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment.
The Journal of investigative dermatology 2001;116(2):261-5.
2001: T Hirao; Mitsuhiro Denda; M Takahashi
Identification of immature cornified envelopes in the barrier-impaired epidermis by characterization of their hydrophobicity and antigenicities of the components.
Experimental dermatology 2001;10(1):35-44.
2000: Mitsuhiro Denda
Influence of dry environment on epidermal function.
Journal of dermatological science 2000;24 Suppl 1():S22-8.
2000: Mitsuhiro Denda; Junichi Hosoi; Y Asida
Visual imaging of ion distribution in human epidermis.
Biochemical and biophysical research communications 2000;272(1):134-7.
2000: Mitsuhiro Denda; T Tsuchiya; K Shoji; M Tanida
Odorant inhalation affects skin barrier homeostasis in mice and humans.
The British journal of dermatology 2000;142(5):1007-10.
2000: Junichi Hosoi; T Hariya; Mitsuhiro Denda; T Tsuchiya
Regulation of the cutaneous allergic reaction by humidity.
Contact dermatitis 2000;42(2):81-4.
1999: Mitsuhiro Denda; Chika Katagiri; T Hirao; N Maruyama; M Takahashi
Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery.
Archives of dermatological research 1999;291(10):560-3.
1998: Junko Sato; Mitsuhiro Denda; J Nakanishi; J Koyama
Dry condition affects desquamation of stratum corneum in vivo.
Journal of dermatological science 1998;18(3):163-9.
1998: Junko Sato; Mitsuhiro Denda; Y Ashida; J Koyama
Loss of water from the stratum corneum induces epidermal DNA synthesis in hairless mice.
Archives of dermatological research 1998;290(11):634-7.
1998: Mitsuhiro Denda; Junko Sato; Y Masuda; T Tsuchiya; J Koyama; M Kuramoto; P M Elias; K R Feingold
Exposure to a dry environment enhances epidermal permeability barrier function.
The Journal of investigative dermatology 1998;111(5):858-63.
1998: Elizabeth Zettersten; Mao-Qiang Man; J Sato; Mitsuhiro Denda; A Farrell; Ruby Ghadially; Mary L Williams; Kenneth R Feingold; Peter M Elias
Recessive x-linked ichthyosis: role of cholesterol-sulfate accumulation in the barrier abnormality.
The Journal of investigative dermatology 1998;111(5):784-90.
1998: Junichi Hosoi; T Tsuchiya; Mitsuhiro Denda; Y Ashida; A Takashima; Richard D Granstein; J Koyama
Modification of LC phenotype and suppression of contact hypersensitivity response by stress.
Journal of cutaneous medicine and surgery 1998;3(2):79-84.
1998: Junko Sato; Mitsuhiro Denda; J Nakanishi; J Nomura; J Koyama
Cholesterol sulfate inhibits proteases that are involved in desquamation of stratum corneum.
The Journal of investigative dermatology 1998;111(2):189-93.
1998: Mitsuhiro Denda; T Tsuchiya; Junichi Hosoi; J Koyama
Immobilization-induced and crowded environment-induced stress delay barrier recovery in murine skin.
The British journal of dermatology 1998;138(5):780-5.
1997: Mitsuhiro Denda; K Kitamura; P M Elias; K R Feingold
trans-4-(Aminomethyl)cyclohexane carboxylic acid (T-AMCHA), an anti-fibrinolytic agent, accelerates barrier recovery and prevents the epidermal hyperplasia induced by epidermal injury in hairless mice and humans.
The Journal of investigative dermatology 1997;109(1):84-90.
1997: Mitsuhiro Denda; Barbara E Brown; Peter M Elias; Kenneth R Feingold
Epidermal injury stimulates prenylation in the epidermis of hairless mice.
Archives of dermatological research 1997;289(2):104-10.
1996: Mitsuhiro Denda; L C Wood; S Emami; C Calhoun; Barbara E Brown; Peter M Elias; Kenneth R Feingold
The epidermal hyperplasia associated with repeated barrier disruption by acetone treatment or tape stripping cannot be attributed to increased water loss.
Archives of dermatological research 1996;288(5-6):230-8.
1994: Mitsuhiro Denda; J Koyama; R Namba; I Horii
Stratum corneum lipid morphology and transepidermal water loss in normal skin and surfactant-induced scaly skin.
Archives of dermatological research 1994;286(1):41-6.
1993: Mitsuhiro Denda; J Koyama; J Hori; I Horii; M Takahashi; M Hara; H Tagami
Age- and sex-dependent change in stratum corneum sphingolipids.
Archives of dermatological research 1993;285(7):415-7.
1992: Mitsuhiro Denda; J Hori; J Koyama; S Yoshida; R Nanba; M Takahashi; I Horii; A Yamamoto
Stratum corneum sphingolipids and free amino acids in experimentally-induced scaly skin.
Archives of dermatological research 1992;284(6):363-7.