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Mutsuki Amano

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Katsuhiro Kato; Mutsuki Amano; Kozo Kaibuchi
[Small GTPases and their effectors].
Katsuhiro Kato; Yoshiharu Matsuura; Kazutaka Mori; Toyoaki Murohara; Tomoki Nishioka; Tadaomi Takenawa; Kentaro Taki; Shujie Wang; Tsubasa Yazawa; Mutsuki Amano; Tomonari Hamaguchi; Toshiki Itoh; Chikako Kataoka; Kozo Kaibuchi
The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.
Tomoki Nishioka; Masanori Nakayama; Mutsuki Amano; Kozo Kaibuchi
Proteomic screening for Rho-kinase substrates by combining kinase and phosphatase inhibitors with 14-3-3ζ affinity chromatography.

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2012: Katsuhiro Kato; Mutsuki Amano; Kozo Kaibuchi
[Small GTPases and their effectors].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():67-70.
2012: Katsuhiro Kato; Yoshiharu Matsuura; Kazutaka Mori; Toyoaki Murohara; Tomoki Nishioka; Tadaomi Takenawa; Kentaro Taki; Shujie Wang; Tsubasa Yazawa; Mutsuki Amano; Tomonari Hamaguchi; Toshiki Itoh; Chikako Kataoka; Kozo Kaibuchi
The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.
Molecular biology of the cell 2012;23(13):2593-604.
2012: Tomoki Nishioka; Masanori Nakayama; Mutsuki Amano; Kozo Kaibuchi
Proteomic screening for Rho-kinase substrates by combining kinase and phosphatase inhibitors with 14-3-3ζ affinity chromatography.
Cell structure and function 2012;37(1):39-48.
2011: Hiroshi Qadota; Takayuki Miyauchi; John F Nahabedian; Jeffrey N Stirman; Hang Lu; Mutsuki Amano; Guy M Benian; Kozo Kaibuchi
PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C. elegans.
Journal of molecular biology 2011;407(2):222-31.
2010: Mutsuki Amano; Masanori Nakayama; Kozo Kaibuchi
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.
Cytoskeleton (Hoboken, N.J.) 2010;67(9):545-54.
2010: Mutsuki Amano; Yuta Tsumura; Kentaro Taki; Hidenori Harada; Kazutaka Mori; Tomoki Nishioka; Katsuhiro Kato; Takeshi Suzuki; Yosuke Nishioka; Akihiro Iwamatsu; Kozo Kaibuchi
A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase.
PloS one 2010;5(1):e8704.
2010: Mikito Takefuji; Hiroyuki Asano; Kazutaka Mori; Mutsuki Amano; Katsuhiro Kato; Takashi Watanabe; Yasuhiro Morita; Akira Katsumi; Toshiki Itoh; Tadaomi Takenawa; Akihiro Hirashiki; Hideo Izawa; Kozo Nagata; Haruo Hirayama; Fumimaro Takatsu; Tomoki Naoe; Mitsuhiro Yokota; Kozo Kaibuchi
Mutation of ARHGAP9 in patients with coronary spastic angina.
Journal of human genetics 2010;55(1):42-9.
2009: Kazutaka Mori; Mutsuki Amano; Mikito Takefuji; Katsuhiro Kato; Yasuhiro Morita; Tomoki Nishioka; Yoshiharu Matsuura; Toyoaki Murohara; Kozo Kaibuchi
Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP.
The Journal of biological chemistry 2009;284(8):5067-76.
2008: Toshihiro Iwasaki; Akira Katsumi; Hitoshi Kiyoi; Ryohei Tanizaki; Yuichi Ishikawa; Kazutaka Ozeki; Miki Kobayashi; Akihiro Abe; Tadashi Matsushita; Takashi Watanabe; Mutsuki Amano; Tetsuhito Kojima; Kozo Kaibuchi; Tomoki Naoe
Prognostic implication and biological roles of RhoH in acute myeloid leukaemia.
European journal of haematology 2008;81(6):454-60.
2008: Masanori Nakayama; Takaaki M Goto; Masayuki Sugimoto; Takashi Nishimura; Takafumi Shinagawa; Sigeo Ohno; Mutsuki Amano; Kozo Kaibuchi
Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation.
Developmental cell 2008;14(2):205-15.
2007: Hiroshi Qadota; Makiko Inoue; Takao Hikita; Mathias Köppen; Jeffrey D Hardin; Mutsuki Amano; Donald G Moerman; Kozo Kaibuchi
Establishment of a tissue-specific RNAi system in C. elegans.
Gene 2007;400(1-2):166-73.
2007: Masayuki Sugimoto; Masanori Nakayama; Takaaki M Goto; Mutsuki Amano; Kimihiro Komori; Kozo Kaibuchi
Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells.
Biochemical and biophysical research communications 2007;361(2):462-7.
2007: Mikito Takefuji; Kazutaka Mori; Yasuhiro Morita; Nariko Arimura; Takashi Nishimura; Masanori Nakayama; Mikio Hoshino; Akihiro Iwamatsu; Toyoaki Murohara; Kozo Kaibuchi; Mutsuki Amano
Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation.
Biochemical and biophysical research communications 2007;355(3):788-94.
2007: Masayuki Iwakubo; Atsuya Takami; Yuji Okada; Takehisa Kawata; Yoshimichi Tagami; Motoko Sato; Terumi Sugiyama; Kayoko Fukushima; Shinichiro Taya; Mutsuki Amano; Kozo Kaibuchi; Hiroshi Iijima
Design and synthesis of rho kinase inhibitors (III).
Bioorganic & medicinal chemistry 2007;15(2):1022-33.
2006: Takatoshi Hizume; Keiko Morikawa; Aya Takaki; Kohtaro Abe; Kenji Sunagawa; Mutsuki Amano; Kozo Kaibuchi; Chiharu Kubo; Hiroaki Shimokawa
Sustained elevation of serum cortisol level causes sensitization of coronary vasoconstricting responses in pigs in vivo: a possible link between stress and coronary vasospasm.
Circulation research 2006;99(7):767-75.
2006: Hiroto Yamaguchi; Yukiko Miwa; Miyuki Kasa; Ken Kitano; Mutsuki Amano; Kozo Kaibuchi; Toshio Hakoshima
Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y-27632.
Journal of biochemistry 2006;140(3):305-11.
2006: Toru Tanaka; Dai Nishimura; Ray-Chang Wu; Mutsuki Amano; Tatsuya Iso; Larry Kedes; Hiroshi Nishida; Kozo Kaibuchi; Yasuo Hamamori
Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase.
The Journal of biological chemistry 2006;281(22):15320-9.
2006: Hiroto Yamaguchi; Miyuki Kasa; Mutsuki Amano; Kozo Kaibuchi; Toshio Hakoshima
Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil.
Structure (London, England : 1993) 2006;14(3):589-600.
2005: Daisuke Tsuboi; Takao Hikita; Hiroshi Qadota; Mutsuki Amano; Kozo Kaibuchi
Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans.
Journal of neurochemistry 2005;95(6):1629-41.
2005: Nariko Arimura; Céline Ménager; Yoji Kawano; Takeshi Yoshimura; Saeko Kawabata; Atsushi Hattori; Yuko Fukata; Mutsuki Amano; Yoshio Goshima; Masaki Inagaki; Nobuhiro Morone; Jiro Usukura; Kozo Kaibuchi
Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones.
Molecular and cellular biology 2005;25(22):9973-84.
2005: Takako Kaneko; Akio Maeda; Mikito Takefuji; Hiroki Aoyama; Masanori Nakayama; Saeko Kawabata; Yoji Kawano; Akihiro Iwamatsu; Mutsuki Amano; Kozo Kaibuchi
Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(10):973-87.
2005: Masanori Nakayama; Mutsuki Amano; Akira Katsumi; Takako Kaneko; Saeko Kawabata; Mikito Takefuji; Kozo Kaibuchi
Rho-kinase and myosin II activities are required for cell type and environment specific migration.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(2):107-17.
2004: Junko Hiroki; Hiroaki Shimokawa; Midoriko Higashi; Keiko Morikawa; Tadashi Kandabashi; Natsumi Kawamura; Toru Kubota; Toshihiro Ichiki; Mutsuki Amano; Kozo Kaibuchi; Akira Takeshita
Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells.
Journal of molecular and cellular cardiology 2004;37(2):537-46.
2004: Saeko Kawabata; Jiro Usukura; Nobuhiro Morone; Masaaki Ito; Akihiro Iwamatsu; Kozo Kaibuchi; Mutsuki Amano
Interaction of Rho-kinase with myosin II at stress fibres.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(7):653-60.
2004: Atsuya Takami; Masayuki Iwakubo; Yuji Okada; Takehisa Kawata; Hideharu Odai; Nobuaki Takahashi; Kazutoshi Shindo; Kaname Kimura; Yoshimichi Tagami; Mika Miyake; Kayoko Fukushima; Masaki Inagaki; Mutsuki Amano; Kozo Kaibuchi; Hiroshi Iijima
Design and synthesis of Rho kinase inhibitors (I).
Bioorganic & medicinal chemistry 2004;12(9):2115-37.
2004: Masanori Nakayama; Mutsuki Amano; Saeko Kawabata; Kozo Kaibuchi; Mikito Takefuji
[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 3():202-6.
2003: Toshiyuki Shimizu; Kentaro Ihara; Ryoko Maesaki; Mutsuki Amano; Kozo Kaibuchi; Toshio Hakoshima
Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase.
The Journal of biological chemistry 2003;278(46):46046-51.
2003: Mutsuki Amano; Takako Kaneko; Akio Maeda; Masanori Nakayama; Masaaki Ito; Takashi Yamauchi; Hideyuki Goto; Yuko Fukata; Noriko Oshiro; Azusa Shinohara; Akihiro Iwamatsu; Kozo Kaibuchi
Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase.
Journal of neurochemistry 2003;87(3):780-90.
2003: Harald Genth; Ralf Gerhard; Akio Maeda; Mutsuki Amano; Kozo Kaibuchi; Klaus Aktories; Ingo Just
Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex.
The Journal of biological chemistry 2003;278(31):28523-7.
2002: Akio Maeda; Mutsuki Amano; Yuko Fukata; Kozo Kaibuchi
Translocation of Na(+),K(+)-ATPase is induced by Rho small GTPase in renal epithelial cells.
Biochemical and biophysical research communications 2002;297(5):1231-7.
2002: Daisuke Tsuboi; Hiroshi Qadota; Katsuhisa Kasuya; Mutsuki Amano; Kozo Kaibuchi
Isolation of the interacting molecules with GEX-3 by a novel functional screening.
Biochemical and biophysical research communications 2002;292(3):697-701.
2001: Naoyuki Inagaki; K Chihara; Nariko Arimura; Céline Ménager; Y Kawano; N Matsuo; Takashi Nishimura; Mutsuki Amano; Kozo Kaibuchi
CRMP-2 induces axons in cultured hippocampal neurons.
Nature neuroscience 2001;4(8):781-2.
2001: Yuko Fukata; Mutsuki Amano; Kozo Kaibuchi
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
Trends in pharmacological sciences 2001;22(1):32-9.
2000: Mutsuki Amano; Yuko Fukata; Kozo Kaibuchi
Regulation and functions of Rho-associated kinase.
Experimental cell research 2000;261(1):44-51.
2000: Nariko Arimura; Naoyuki Inagaki; K Chihara; Céline Ménager; N Nakamura; Mutsuki Amano; Akihiro Iwamatsu; Yoshio Goshima; Kozo Kaibuchi
Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse.
The Journal of biological chemistry 2000;275(31):23973-80.
2000: Kentaro Ihara; Toshiyuki Shimizu; Ryoko Maesaki; Kengo Okada; Mutsuki Amano; Kozo Kaibuchi; Toshio Hakoshima
Crystallization and preliminary crystallographic analysis of the Rho-binding domain of bovine Rho-kinase.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 8):1042-4.
2000: N Nakamura; Noriko Oshiro; Yuko Fukata; Mutsuki Amano; Masaki Fukata; Shinya Kuroda; Y Matsuura; T Leung; L Lim; Kozo Kaibuchi
Phosphorylation of ERM proteins at filopodia induced by Cdc42.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(7):571-81.
2000: T Kaneko; Mutsuki Amano; A Maeda; H Goto; K Takahashi; M Ito; Kozo Kaibuchi
Identification of calponin as a novel substrate of Rho-kinase.
Biochemical and biophysical research communications 2000;273(1):110-6.
2000: Yasuhiro Eto; Hiroaki Shimokawa; Junko Hiroki; Kunio Morishige; Tadashi Kandabashi; Yasuharu Matsumoto; Mutsuki Amano; M Hoshijima; Kozo Kaibuchi; Akira Takeshita
Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs.
American journal of physiology. Heart and circulatory physiology 2000;278(6):H1744-50.
2000: Mutsuki Amano; Yuko Fukata; H Shimokawa; Kozo Kaibuchi
Purification and in vitro activity of Rho-associated kinase.
Methods in enzymology 2000;325():149-55.
1999: Y Kawano; Yuko Fukata; Noriko Oshiro; Mutsuki Amano; T Nakamura; Masaaki Ito; F Matsumura; M Inagaki; Kozo Kaibuchi
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo.
The Journal of cell biology 1999;147(5):1023-38.
1999: Mutsuki Amano; K Chihara; N Nakamura; T Kaneko; Y Matsuura; Kozo Kaibuchi
The COOH terminus of Rho-kinase negatively regulates rho-kinase activity.
The Journal of biological chemistry 1999;274(45):32418-24.
1999: T Mizuno; Mutsuki Amano; Kozo Kaibuchi; Y Nishida
Identification and characterization of Drosophila homolog of Rho-kinase.
Gene 1999;238(2):437-44.
1999: Hiroaki Shimokawa; Minoru Seto; N Katsumata; Mutsuki Amano; Toshiyuki Kozai; Tohru Yamawaki; Koichi Kuwata; Tadashi Kandabashi; Kensuke Egashira; Ichiro Ikegaki; Toshio Asano; Kozo Kaibuchi; Akira Takeshita
Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.
Cardiovascular research 1999;43(4):1029-39.
1998: I Izawa; Mutsuki Amano; K Chihara; T Yamamoto; Kozo Kaibuchi
Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.
Oncogene 1998;17(22):2863-71.
1998: Mutsuki Amano; K Chihara; N Nakamura; Yuko Fukata; T Yano; M Shibata; M Ikebe; Kozo Kaibuchi
Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase.
Genes to cells : devoted to molecular & cellular mechanisms 1998;3(3):177-88.
1997: K Chihara; Mutsuki Amano; N Nakamura; T Yano; M Shibata; T Tokui; H Ichikawa; R Ikebe; M Ikebe; Kozo Kaibuchi
Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase.
The Journal of biological chemistry 1997;272(40):25121-7.
1997: Mutsuki Amano; K Chihara; K Kimura; Yuko Fukata; N Nakamura; Y Matsuura; Kozo Kaibuchi
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase.
Science (New York, N.Y.) 1997;275(5304):1308-11.
1996: Mutsuki Amano; M Ito; K Kimura; Yuko Fukata; K Chihara; T Nakano; Y Matsuura; Kozo Kaibuchi
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase).
The Journal of biological chemistry 1996;271(34):20246-9.
1996: K Kimura; M Ito; Mutsuki Amano; K Chihara; Yuko Fukata; M Nakafuku; B Yamamori; J Feng; T Nakano; K Okawa; Akihiro Iwamatsu; Kozo Kaibuchi
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
Science (New York, N.Y.) 1996;273(5272):245-8.
1996: T Matsui; Mutsuki Amano; T Yamamoto; K Chihara; M Nakafuku; M Ito; T Nakano; K Okawa; Akihiro Iwamatsu; Kozo Kaibuchi
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.
The EMBO journal 1996;15(9):2208-16.
1996: Mutsuki Amano; H Mukai; Y Ono; K Chihara; T Matsui; Y Hamajima; K Okawa; Akihiro Iwamatsu; Kozo Kaibuchi
Identification of a putative target for Rho as the serine-threonine kinase protein kinase N.
Science (New York, N.Y.) 1996;271(5249):648-50.