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Cécile Denis

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Paulette Legendre; Peter J Lenting; Ana-Maria Navarrete; Julie Rayes; Catherine Ternisien; Agnès Veyradier; Pierre Boisseau; Claudine Caron; Caterina Casari; Cécile V Denis; Edith Fressinaud; Jenny Goudemand; Olivier D Christophe
Mutations in the A3 domain of von Willebrand factor inducing combined qualitative and quantitative defects in the protein.
Peter J Lenting; C Casari; Olivier D Christophe; Cécile V Denis
von Willebrand factor: the old, the new and the unknown.
Julie N Pegon; Soline Odouard; Caterina Casari; Olivier D Christophe; Cécile V Denis; Mohamad Kurdi; Peter J Lenting
Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5.

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All Publications

2013: Paulette Legendre; Peter J Lenting; Ana-Maria Navarrete; Julie Rayes; Catherine Ternisien; Agnès Veyradier; Pierre Boisseau; Claudine Caron; Caterina Casari; Cécile V Denis; Edith Fressinaud; Jenny Goudemand; Olivier D Christophe
Mutations in the A3 domain of von Willebrand factor inducing combined qualitative and quantitative defects in the protein.
Blood 2013;121(11):2135-43.
2012: Peter J Lenting; C Casari; Olivier D Christophe; Cécile V Denis
von Willebrand factor: the old, the new and the unknown.
Journal of thrombosis and haemostasis : JTH 2012;10(12):2428-37.
2012: Julie N Pegon; Soline Odouard; Caterina Casari; Olivier D Christophe; Cécile V Denis; Mohamad Kurdi; Peter J Lenting
Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5.
Haematologica 2012;97(12):1855-63.
2012: Ana-Maria Navarrete; Caterina Casari; Olivier D Christophe; Jiun-Ruey Hu; Paulette Legendre; Peter J Lenting; Isabelle Marx; Cécile V Denis
A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor.
Blood 2012;120(13):2723-32.
2012: Cécile V Denis; Peter J Lenting
von Willebrand factor: at the crossroads of bleeding and thrombosis.
International journal of hematology 2012;95(4):353-61.
2012: Nathalie Saint-Lu; Soline Odouard; Beatrijs D Oortwijn; Julie N Pegon; Olivier D Christophe; Philip G de Groot; Cécile V Denis; Peter J Lenting
Identification of galectin-1 and galectin-3 as novel partners for von Willebrand factor.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(4):894-901.
2012: Ghasem Rastegarlari; Nathalie Saint-Lu; Bart J van Vlijmen; Ana-Maria Navarrete; Soline Odouard; Julie N Pegon; Caterina Casari; Olivier D Christophe; Cécile V Denis; Paulette Legendre; Peter J Lenting
Macrophage LRP1 contributes to the clearance of von Willebrand factor.
Blood 2012;119(9):2126-34.
2012: Mohamad Kurdi; Peter J Lenting; Ghislaine Cherel; Cécile V Denis; Olivier D Christophe
Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance.
PloS one 2012;7(9):e45111.
2012: Idinath Badirou; Marijke Bryckaert; Caterina Casari; Olivier D Christophe; Mohamad Kurdi; Paulette Legendre; Peter J Lenting; Julie Rayes; Cécile V Denis
In vivo analysis of the role of O-glycosylations of von Willebrand factor.
PloS one 2012;7(5):e37508.
2011: Mathieu Schaff; Nicolas Receveur; Catherine Bourdon; Virginie Wurtz; Cécile V Denis; Gertraud Orend; Christian Gachet; François Lanza; Pierre H Mangin
Novel function of tenascin-C, a matrix protein relevant to atherosclerosis, in platelet recruitment and activation under flow.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(1):117-24.
2010: I Badirou; M Kurdi; J Rayes; Paulette Legendre; Olivier D Christophe; Peter J Lenting; Cécile V Denis
von Willebrand factor clearance does not involve proteolysis by ADAMTS-13.
Journal of thrombosis and haemostasis : JTH 2010;8(10):2338-40.
2010: Simon F De Meyer; Tobias Schwarz; Hans Deckmyn; Cécile V Denis; Bernhard Nieswandt; Guido Stoll; Karen Vanhoorelbeke; Christoph Kleinschnitz
Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(10):1949-51.
2010: Monique Fabre; Anne Leroy-Willig; Cécile V Denis; Nathalie Ba; Damien Schoëvaërt; Catherine Guettier; Danielle Geldwerth-Feniger
In vivo MRI and ex vivo quantification of iron and Kupffer cells demonstrate residual phagocytic activity in mouse liver after a gadolinium chloride injection.
Biochimie 2010;92(10):1343-53.
2010: P Guéguen; G Cherel; I Badirou; Cécile V Denis; Olivier D Christophe
Two residues in the activation peptide domain contribute to the half-life of factor X in vivo.
Journal of thrombosis and haemostasis : JTH 2010;8(7):1651-3.
2010: Julie Rayes; Martine J Hollestelle; Paulette Legendre; Isabelle Marx; Philip G de Groot; Olivier D Christophe; Peter J Lenting; Cécile V Denis
Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B.
Blood 2010;115(23):4870-7.
2010: Peter J Lenting; Geertje H A Westerlaken; Cécile V Denis; Jan Willem Akkerman; Linde Meyaard
Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member.
PloS one 2010;5(8):e12174.
2009: S Shahbazi; R Mahdian; F A Ala; Jean-Maurice Lavergne; Cécile V Denis; Olivier D Christophe
Molecular characterization of Iranian patients with type 3 von Willebrand disease.
Haemophilia : the official journal of the World Federation of Hemophilia 2009;15(5):1058-64.
2009: R Pendu; O D Christophe; Cécile V Denis
Mouse models of von Willebrand disease.
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():61-4.
2009: Nicolas Lerolle; C Dunois-Lardé; I Badirou; D G Motto; GARY HILL; Patrick Bruneval; Jean-Luc Diehl; Cécile V Denis; Dominique Baruch
von Willebrand factor is a major determinant of ADAMTS-13 decrease during mouse sepsis induced by cecum ligation and puncture.
Journal of thrombosis and haemostasis : JTH 2009;7(5):843-50.
2009: Kathelijn Fischer; Ronan Pendu; Carina J M van Schooten; Karin van Dijk; Cécile V Denis; H Marijke van den Berg; Peter J Lenting
Models for prediction of factor VIII half-life in severe haemophiliacs: distinct approaches for blood group O and non-O patients.
PloS one 2009;4(8):e6745.
2009: Cécile V Denis; I Marx; I Badirou; Ronan Pendu; Olivier D Christophe
Mouse models to study von Willebrand factor structure-function relationships in vivo.
Hämostaseologie 2009;29(1):17-8, 20.
2008: Carina J M van Schooten; Shirin Shahbazi; Evelyn Groot; Beatrijs D Oortwijn; H Marijke van den Berg; Cécile V Denis; Peter J Lenting
Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo.
Blood 2008;112(5):1704-12.
2008: Isabelle Marx; Olivier D Christophe; Peter J Lenting; Alain Rupin; Marie-Odile Vallez; Tony J Verbeuren; Cécile V Denis
Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa.
Blood 2008;112(3):603-9.
2008: Patricia P Spijkers; Cécile V Denis; Anna M Blom; Peter J Lenting
Cellular uptake of C4b-binding protein is mediated by heparan sulfate proteoglycans and CD91/LDL receptor-related protein.
European journal of immunology 2008;38(3):809-17.
2008: Isabelle Marx; Peter J Lenting; Thure Adler; Ronan Pendu; Olivier D Christophe; Cécile V Denis
Correction of bleeding symptoms in von Willebrand factor-deficient mice by liver-expressed von Willebrand factor mutants.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(3):419-24.
2008: Cécile V Denis; Olivier D Christophe; Beatrijs D Oortwijn; Peter J Lenting
Clearance of von Willebrand factor.
Thrombosis and haemostasis 2008;99(2):271-8.
2007: S Shahbazi; Peter J Lenting; Caroline Fribourg; Virginie Terraube; Cécile V Denis; Olivier D Christophe
Characterization of the interaction between von Willebrand factor and osteoprotegerin.
Journal of thrombosis and haemostasis : JTH 2007;5(9):1956-62.
2007: Peter J Lenting; Carina J M van Schooten; Cécile V Denis
Clearance mechanisms of von Willebrand factor and factor VIII.
Journal of thrombosis and haemostasis : JTH 2007;5(7):1353-60.
2007: Peter J Lenting; Cécile V Denis
von Willebrand factor A1 domain: stuck in the middle.
Journal of thrombosis and haemostasis : JTH 2007;5(7):1361-2.
2007: Cécile V Denis; Denisa D Wagner
Platelet adhesion receptors and their ligands in mouse models of thrombosis.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):728-39.
2007: Jovanka Bestebroer; Miriam J J G Poppelier; Laurien H Ulfman; Peter J Lenting; Cécile V Denis; Kok P M van Kessel; Jos van Strijp; Carla J C de Haas
Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.
Blood 2007;109(7):2936-43.
2007: Carina J M van Schooten; Cécile V Denis; Ton Lisman; J C J Eikenboom; Frank W G Leebeek; Jenny Goudemand; Edith Fressinaud; H Marijke van den Berg; Philip G de Groot; Peter J Lenting
Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels.
Blood 2007;109(6):2430-7.
2007: Peter J Lenting; Philip G de Groot; Simon F De Meyer; Karen Vanhoorelbeke; Cynthia Pruss; David Lillicrap; Isabelle Marx; Cécile V Denis
Correction of the bleeding time in von Willebrand factor (VWF)-deficient mice using murine VWF.
Blood 2007;109(5):2267-8.
2007: Virginie Terraube; Isabelle Marx; Cécile V Denis
Role of von Willebrand factor in tumor metastasis.
Thrombosis research 2007;120 Suppl 2():S64-70.
2006: Ronan Pendu; Virginie Terraube; Olivier D Christophe; Carl G Gahmberg; Philip G de Groot; Peter J Lenting; Cécile V Denis
P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor.
Blood 2006;108(12):3746-52.
2006: Virginie Terraube; Ronan Pendu; Dominique Baruch; Martijn F B G Gebbink; D Meyer; Peter J Lenting; Cécile V Denis
Increased metastatic potential of tumor cells in von Willebrand factor-deficient mice.
Journal of thrombosis and haemostasis : JTH 2006;4(3):519-26.
2005: C J Schooten; Pernilla Tjernberg; Erik Westein; Virginie Terraube; Giancarlo Castaman; J A Mourik; Martine J Hollestelle; Hans L Vos; Rogier M Bertina; H M Berg; J C J Eikenboom; Peter J Lenting; Cécile V Denis
Cysteine-mutations in von Willebrand factor associated with increased clearance.
Journal of thrombosis and haemostasis : JTH 2005;3(10):2228-37.
2005: Cécile V Denis; Sarah J Roberts; Tilman M Hackeng; Peter J Lenting
In vivo clearance of human protein S in a mouse model: influence of C4b-binding protein and the Heerlen polymorphism.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(10):2209-15.
2004: Peter J Lenting; Erik Westein; Virginie Terraube; Anne-Sophie Ribba; Eric G Huizinga; Dominique Meyer; Philip G de Groot; Cécile V Denis
An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation.
The Journal of biological chemistry 2004;279(13):12102-9.
2004: Jeffrey F W Keuren; Dominique Baruch; Paulette Legendre; Cécile V Denis; Peter J Lenting; Jean-Pierre Girma; Theo Lindhout
von Willebrand factor C1C2 domain is involved in platelet adhesion to polymerized fibrin at high shear rate.
Blood 2004;103(5):1741-6.
2003: Cécile V Denis
Von Willebrand factor in vascular pathophysiology.
Pathologie-biologie 2003;51(7):395-6.
2003: Cécile V Denis; Virginie Terraube; Karine Robert; Nathalie Janel
Elevated plasma von Willebrand factor in a murine model of severe hyperhomocysteinemia.
Thrombosis and haemostasis 2003;90(2):362-4.
2003: Karin M Hoffmeister; Thomas W Felbinger; Hervé Falet; Cécile V Denis; Wolfgang Bergmeier; Tanya N Mayadas; Ulrich H von Andrian; Denisa D Wagner; Thomas P Stossel; John H Hartwig
The clearance mechanism of chilled blood platelets.
Cell 2003;112(1):87-97.
2002: Nadine Ajzenberg; Cécile V Denis; Agnès Veyradier; Jean-Pierre Girma; Dominique Meyer; Dominique Baruch
Complete defect in vWF-cleaving protease activity associated with increased shear-induced platelet aggregation in thrombotic microangiopathy.
Thrombosis and haemostasis 2002;87(5):808-11.
2002: Patrick André; K S Srinivasa Prasad; Cécile V Denis; Ming He; Jessie M Papalia; Richard O Hynes; David R Phillips; Denisa D Wagner
CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism.
Nature medicine 2002;8(3):247-52.
2002: Erik Westein; Cécile V Denis; Bonno N Bouma; Peter J Lenting
The alpha -chains of C4b-binding protein mediate complex formation with low density lipoprotein receptor-related protein.
The Journal of biological chemistry 2002;277(4):2511-6.
2002: Cécile V Denis
Molecular and cellular biology of von Willebrand factor.
International journal of hematology 2002;75(1):3-8.
2001: N Methia; Patrick André; Cécile V Denis; M Economopoulos; Denisa D Wagner
Localized reduction of atherosclerosis in von Willebrand factor-deficient mice.
Blood 2001;98(5):1424-8.
2001: Cécile V Denis; Patrick André; Simin Saffaripour; Denisa D Wagner
Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4072-7.
2001: Cécile V Denis; K Kwack; Simin Saffaripour; S Maganti; Patrick André; Robert G Schaub; Denisa D Wagner
Interleukin 11 significantly increases plasma von Willebrand factor and factor VIII in wild type and von Willebrand disease mouse models.
Blood 2001;97(2):465-72.
2000: Patrick André; Cécile V Denis; Jerry Ware; Simin Saffaripour; Richard O Hynes; Zaverio M Ruggeri; Denisa D Wagner
Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins.
Blood 2000;96(10):3322-8.
2000: H Ni; Cécile V Denis; S Subbarao; J L Degen; T N Sato; R O Hynes; Denisa D Wagner
Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen.
The Journal of clinical investigation 2000;106(3):385-92.
2000: Paul S. Frenette; Cécile V Denis; L Weiss; Kerstin Jurk; S Subbarao; Beate Kehrel; John H Hartwig; Dietmar Vestweber; Denisa D Wagner
P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo.
The Journal of experimental medicine 2000;191(8):1413-22.
1999: Cécile V Denis; Denisa D Wagner
Insights from von Willebrand disease animal models.
Cellular and molecular life sciences : CMLS 1999;56(11-12):977-90.
1999: N Methia; Cécile V Denis; Denisa D Wagner
Carboxypeptidase E does not mediate von Willebrand factor targeting to storage granules.
European journal of cell biology 1999;78(12):884-91.