Mitchell Denning

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TOP 3
Jerome-Morais Anita; Rahn Heidi R; Tibudan Shalini S; Denning Mitchell F
Role for protein kinase C-alpha in keratinocyte growth arrest.
Sitailo Leonid A; Jerome-Morais Anita; Denning Mitchell F
Mcl-1 functions as major epidermal survival protein required for proper keratinocyte differentiation.
Brown Meredith V; Burnett Patrick E; Denning Mitchell F; Reynolds Albert B
PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway.

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All Publications

2009: Jerome-Morais Anita; Rahn Heidi R; Tibudan Shalini S; Denning Mitchell F
Role for protein kinase C-alpha in keratinocyte growth arrest.
The Journal of investigative dermatology 2009;129(10):2365-75.
2009: Sitailo Leonid A; Jerome-Morais Anita; Denning Mitchell F
Mcl-1 functions as major epidermal survival protein required for proper keratinocyte differentiation.
The Journal of investigative dermatology 2009;129(6):1351-60.
2009: Brown Meredith V; Burnett Patrick E; Denning Mitchell F; Reynolds Albert B
PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway.
Experimental cell research 2009;315(1):39-49.
2008: Yang Guang; Li Yitang; Nishimura Emi K; Xin Hong; Zhou Anyu; Guo Yinshi; Dong Liang; Denning Mitchell F; Nickoloff Brian J; Cui Rutao
Inhibition of PAX3 by TGF-beta modulates melanocyte viability.
Molecular cell 2008;32(4):554-63.
2008: Bass-Zubek Amanda E; Hobbs Ryan P; Amargo Evangeline V; Garcia Nicholas J; Hsieh Sherry N; Chen Xinyu; Wahl James K; Denning Mitchell F; Green Kathleen J
Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly.
The Journal of cell biology 2008;181(4):605-13.
2007: Breitkreutz D; Braiman-Wiksman L; Daum N; Denning M F; Tennenbaum T
Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium.
Journal of cancer research and clinical oncology 2007;133(11):793-808.
2007: Denning Mitchell F
Tightening the epidermal barrier with atypical PKCs.
The Journal of investigative dermatology 2007;127(4):742-4.
2006: Qin Jian-Zhong; Xin Hong; Sitailo Leonid A; Denning Mitchell F; Nickoloff Brian J
Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA.
Cancer research 2006;66(19):9636-45.
2006: Sitailo Leonid A; Tibudan Shalini S; Denning Mitchell F
The protein kinase C delta catalytic fragment targets Mcl-1 for degradation to trigger apoptosis.
The Journal of biological chemistry 2006;281(40):29703-10.
2006: Guo Hong; Miao Hui; Gerber Lizabeth; Singh Jarnail; Denning Mitchell F; Gilliam Anita C; Wang Bingcheng
Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin.
Cancer research 2006;66(14):7050-8.
2006: Fan Jianhua; Guan Shengxi; Cheng Chieh-Fang; Cho Michele; Fields Joshua W; Chen Mei; Denning Mitchell F; Woodley David T; Li Wei
PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration.
The Journal of investigative dermatology 2006;126(6):1233-43.
2006: Chaturvedi Vijaya; Sitailo Leonid A; Bodner Barbara; Denning Mitchell F; Nickoloff Brian J
Defining the caspase-containing apoptotic machinery contributing to cornification in human epidermal equivalents.
Experimental dermatology 2006;15(1):14-22.
2006: D'Costa A M; Robinson J K; Maududi T; Chaturvedi V; Nickoloff B J; Denning M F
The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas.
Oncogene 2006;25(3):378-86.
2005: Chaturvedi Vijaya; Sitailo Leonid A; Qin Jian-Zhong; Bodner Barbara; Denning Mitchell F; Curry Jonathan; Zhang Wengeng; Brash Douglas; Nickoloff Brian J
Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosis.
Oncogene 2005;24(34):5299-312.
2005: Alkan Serhan; Huang Qin; Ergin Melek; Denning Mitchell F; Nand Sucha; Maududi Tazeen; Paner Gladell P; Ozpuyan Fulya; Izban Keith F
Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition.
American journal of hematology 2005;79(2):97-106.
2005: D'Costa A M; Denning M F
A caspase-resistant mutant of PKC-delta protects keratinocytes from UV-induced apoptosis.
Cell death and differentiation 2005;12(3):224-32.
2004: Sitailo Leonid A; Tibudan Shalini S; Denning Mitchell F
Bax activation and induction of apoptosis in human keratinocytes by the protein kinase C delta catalytic domain.
The Journal of investigative dermatology 2004;123(3):434-43.
2004: Qin Jian-Zhong; Bacon Patricia; Panella Jeffrey; Sitailo Leonid A; Denning Mitchell F; Nickoloff Brian J
Low-dose UV-radiation sensitizes keratinocytes to TRAIL-induced apoptosis.
Journal of cellular physiology 2004;200(1):155-66.
2004: Denning Mitchell F
Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms.
The international journal of biochemistry & cell biology 2004;36(7):1141-6.
2003: Chaturvedi Vijaya; Bonish Brian; Bacon Patricia; Qin Jian-Zhong; Denning Mitchell F; Foreman Kimberly; Diaz Manuel O; Robinson June; Nickoloff Brian J
Role for Id-1 in immunobiology of normal keratinocytes and in basal cell carcinoma.
Experimental dermatology 2003;12(3):255-60.
2003: Ni Hongyu; Ergin Melek; Tibudan Shalini S; Denning Mitch F; Izban Keith F; Alkan Serhan
Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis.
British journal of haematology 2003;121(6):849-56.
2002: Nickoloff Brian J; Qin Jian-Zhong; Chaturvedi Vijava; Bacon Patricia; Panella Jeffrey; Denning Mitchell F
Life and death signaling pathways contributing to skin cancer.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2002;7(1):27-35.
2002: Tibudan Shalini S; Wang Yihua; Denning Mitchell F
Activation of protein kinase C triggers irreversible cell cycle withdrawal in human keratinocytes.
The Journal of investigative dermatology 2002;119(6):1282-9.
2002: Nickoloff B J; Qin J-Z; Chaturvedi V; Denning M F; Bonish B; Miele L
Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma.
Cell death and differentiation 2002;9(8):842-55.
2002: Qin Jian-Zhong; Chaturvedi Vijaya; Denning Mitchell F; Bacon Patricia; Panella Jeffry; Choubey Divaker; Nickoloff Brian J
Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes.
Oncogene 2002;21(19):2991-3002.
2002: Sitailo Leonid A; Tibudan Shalini S; Denning Mitchell F
Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes.
The Journal of biological chemistry 2002;277(22):19346-52.
2002: Denning M F; Wang Y; Tibudan S; Alkan S; Nickoloff B J; Qin J-Z
Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C.
Cell death and differentiation 2002;9(1):40-52.
2002: Weinberg Wendy C; Denning Mitchell F
P21Waf1 control of epithelial cell cycle and cell fate.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 2002;13(6):453-64.
2001: Ergin M; Denning M F; Izban K F; Amin H M; Martinez R L; Saeed S; Alkan S
Inhibition of tyrosine kinase activity induces caspase-dependent apoptosis in anaplastic large cell lymphoma with NPM-ALK (p80) fusion protein.
Experimental hematology 2001;29(9):1082-90.
2001: Nickoloff B J; Denning M
Sensing and killing bacteria in skin: innate immune defense system: good and bad news.
The Journal of investigative dermatology 2001;117(1):2, 170.
2001: Nickoloff B J; Denning M
C1q does not complement the removal of apoptotic keratinocytes in vivo.
The Journal of investigative dermatology 2001;117(1):170.
2001: Nickoloff B J; Denning M
Life and death signaling in epidermis: following a planned cell death pathway involving a trail that does not lead to skin cancer.
The Journal of investigative dermatology 2001;117(1):1-2.
2001: Alt A; Ohba M; Li L; Gartsbein M; Belanger A; Denning M F; Kuroki T; Yuspa S H; Tennenbaum T
Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment.
Cancer research 2001;61(11):4591-8.
2001: Park G T; Denning M F; Morasso M I
Phosphorylation of murine homeodomain protein Dlx3 by protein kinase C.
FEBS letters 2001;496(1):60-5.
2001: Chaturvedi V; Qin J Z; Denning M F; Choubey D; Diaz M O; Nickoloff B J
Abnormal NF-kappaB signaling pathway with enhanced susceptibility to apoptosis in immortalized keratinocytes.
Journal of dermatological science 2001;26(1):67-78.
2000: Amin H M; Ergin M; Denning M F; Quevedo M E; Alkan S
Characterization of apoptosis induced by protein kinase C inhibitors and its modulation by the caspase pathway in acute promyelocytic leukaemia.
British journal of haematology 2000;110(3):552-62.
2000: Nickoloff B J; Chaturvedi V; Bacon P; Qin J Z; Denning M F; Diaz M O
Id-1 delays senescence but does not immortalize keratinocytes.
The Journal of biological chemistry 2000;275(36):27501-4.
2000: Denning M F; Dlugosz A A; Cheng C; Dempsey P J; Coffey R J; Threadgill D W; Magnuson T; Yuspa S H
Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes.
Experimental dermatology 2000;9(3):192-9.
1999: Qin J Z; Chaturvedi V; Denning M F; Choubey D; Diaz M O; Nickoloff B J
Role of NF-kappaB in the apoptotic-resistant phenotype of keratinocytes.
The Journal of biological chemistry 1999;274(53):37957-64.
1999: Chaturvedi V; Qin J Z; Denning M F; Choubey D; Diaz M O; Nickoloff B J
Apoptosis in proliferating, senescent, and immortalized keratinocytes.
The Journal of biological chemistry 1999;274(33):23358-67.
1998: Denning M F; Wang Y; Nickoloff B J; Wrone-Smith T
Protein kinase Cdelta is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes.
The Journal of biological chemistry 1998;273(45):29995-30002.
1998: Denning M F; Guy S G; Ellerbroek S M; Norvell S M; Kowalczyk A P; Green K J
The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C.
Experimental cell research 1998;239(1):50-9.
1997: Kowalczyk A P; Bornslaeger E A; Borgwardt J E; Palka H L; Dhaliwal A S; Corcoran C M; Denning M F; Green K J
The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes.
The Journal of cell biology 1997;139(3):773-84.
1997: Dlugosz A A; Hansen L; Cheng C; Alexander N; Denning M F; Threadgill D W; Magnuson T; Coffey R J; Yuspa S H
Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras.
Cancer research 1997;57(15):3180-8.
1996: Yuspa S H; Dlugosz A A; Denning M F; Glick A B
Multistage carcinogenesis in the skin.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1996;1(2):147-50.
1996: Stanwell C; Denning M F; Rutberg S E; Cheng C; Yuspa S H; Dlugosz A A
Staurosporine induces a sequential program of mouse keratinocyte terminal differentiation through activation of PKC isozymes.
The Journal of investigative dermatology 1996;106(3):482-9.
1996: Denning M F; Dlugosz A A; Threadgill D W; Magnuson T; Yuspa S H
Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.
The Journal of biological chemistry 1996;271(10):5325-31.
1995: Denning M F; Kazanietz M G; Blumberg P M; Yuspa S H
Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(12):1619-26.
1995: Szallasi Z; Denning M F; Chang E Y; Rivera J; Yuspa S H; Lehel C; Olah Z; Anderson W B; Blumberg P M
Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.
Biochemical and biophysical research communications 1995;214(3):888-94.
1995: Kartasova T; Scandurro A B; Denning M F; Wirth P J; Yuspa S H; Lichti U
Factors mediating the interactions between epidermal and dermal cells in skin grafts that might be important for hair follicle development.
The Journal of investigative dermatology 1995;104(5 Suppl):21S-22S.
1995: Denning M F; Dlugosz A A; Williams E K; Szallasi Z; Blumberg P M; Yuspa S H
Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(2):149-57.
1994: Dlugosz A A; Cheng C; Williams E K; Dharia A G; Denning M F; Yuspa S H
Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha.
Cancer research 1994;54(24):6413-20.
1994: Dlugosz A A; Cheng C; Denning M F; Dempsey P J; Coffey R J; Yuspa S H
Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in cultured epidermal keratinocytes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(12):1283-92.
1994: Szallasi Z; Denning M F; Smith C B; Dlugosz A A; Yuspa S H; Pettit G R; Blumberg P M
Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation.
Molecular pharmacology 1994;46(5):840-50.
1994: Yuspa S H; Dlugosz A A; Cheng C K; Denning M F; Tennenbaum T; Glick A B; Weinberg W C
Role of oncogenes and tumor suppressor genes in multistage carcinogenesis.
The Journal of investigative dermatology 1994;103(5 Suppl):90S-95S.
1994: Punnonen K; Denning M F; Rhee S G; Yuspa S H
Differences in the regulation of phosphatidylinositol-specific phospholipase C in normal and neoplastic keratinocytes.
Molecular carcinogenesis 1994;10(4):216-25.
1994: Denning M F; Verma A K
The mechanism of the inhibition of squamous differentiation of rat tracheal 2C5 cells by retinoic acid.
Carcinogenesis 1994;15(3):503-7.
1993: Denning M F; Dlugosz A A; Howett M K; Yuspa S H
Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta.
The Journal of biological chemistry 1993;268(35):26079-81.
1993: Punnonen K; Denning M; Lee E; Li L; Rhee S G; Yuspa S H
Keratinocyte differentiation is associated with changes in the expression and regulation of phospholipase C isoenzymes.
The Journal of investigative dermatology 1993;101(5):719-26.
1992: Verma A K; Shoemaker A; Simsiman R; Denning M; Zachman R D
Expression of retinoic acid nuclear receptors and tissue transglutaminase is altered in various tissues of rats fed a vitamin A-deficient diet.
The Journal of nutrition 1992;122(11):2144-52.
1991: Denning M F; Verma A K
Involvement of retinoic acid nuclear receptors in retinoic acid-induced tissue transglutaminase gene expression in rat tracheal 2C5 cells.
Biochemical and biophysical research communications 1991;175(1):344-50.
1990: Hsieh J T; Denning M F; Heidel S M; Verma A K
Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells.
Cancer research 1990;50(8):2239-44.

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Mitchell Denning

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