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Patrick Dennis

Research Profile

Chemicals & Drugs

Phenomena

Phosphorylation

Physiology

Anatomy

Genes & Molecular Sequences

Amino Acid Sequences

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Molecular Sequence Data

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Publications

TOP 3
Anja Jaeschke; Patrick B Dennis; G Thomas
mTOR: a mediator of intracellular homeostasis.
Masao Saitoh; Nicholas Pullen; Paul Brennan; Doreen A Cantrell; Patrick B Dennis; George Thomas
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.
Patrick B Dennis; Anja Jaeschke; M Saitoh; B Fowler; Sara C Kozma; George Thomas
Mammalian TOR: a homeostatic ATP sensor.

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All Publications

2004: Anja Jaeschke; Patrick B Dennis; G Thomas
mTOR: a mediator of intracellular homeostasis.
Current topics in microbiology and immunology 2004;279():283-98.
2002: Masao Saitoh; Nicholas Pullen; Paul Brennan; Doreen A Cantrell; Patrick B Dennis; George Thomas
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.
The Journal of biological chemistry 2002;277(22):20104-12.
2001: Patrick B Dennis; Anja Jaeschke; M Saitoh; B Fowler; Sara C Kozma; George Thomas
Mammalian TOR: a homeostatic ATP sensor.
Science (New York, N.Y.) 2001;294(5544):1102-5.
1999: Patrick B Dennis; Stefano Fumagalli; George Thomas
Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation.
Current opinion in genetics & development 1999;9(1):49-54.
1998: Patrick B Dennis; Nicholas Pullen; RB Pearson; Sara C Kozma; George Thomas
Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation.
The Journal of biological chemistry 1998;273(24):14845-52.
1998: Nicholas Pullen; Patrick B Dennis; M Andjelkovic; A Dufner; Sara C Kozma; Brian A Hemmings; George Thomas
Phosphorylation and activation of p70s6k by PDK1.
Science (New York, N.Y.) 1998;279(5351):707-10.
1997: B A Moser; Patrick B Dennis; Nicholas Pullen; RB Pearson; N A Williamson; Richard E H Wettenhall; Sara C Kozma; George Thomas
Dual requirement for a newly identified phosphorylation site in p70s6k.
Molecular and cellular biology 1997;17(9):5648-55.
1997: S R von Manteuffel; Patrick B Dennis; Nicholas Pullen; Anne-Claude Gingras; N Sonenberg; George Thomas
The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k.
Molecular and cellular biology 1997;17(9):5426-36.
1997: H B Jefferies; Stefano Fumagalli; Patrick B Dennis; C Reinhard; RB Pearson; George Thomas
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.
The EMBO journal 1997;16(12):3693-704.
1996: Patrick B Dennis; Nicholas Pullen; Sara C Kozma; George Thomas
The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.
Molecular and cellular biology 1996;16(11):6242-51.
1995: Richard B Pearson; Patrick B Dennis; J W Han; N A Williamson; Sara C Kozma; Richard E H Wettenhall; George Thomas
The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.
The EMBO journal 1995;14(21):5279-87.
1995: J W Han; Richard B Pearson; Patrick B Dennis; George Thomas
Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites.
The Journal of biological chemistry 1995;270(36):21396-403.