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Nunzio Denora

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Nunzio Denora; Andrea Giuffrida; Leonardo Laconca; Valentino Laquintana; Antonio Lopalco; Adriana Trapani; Tommaso Cassano; Concetta Stefania Cimmino; Giuseppe Trapani
Novel codrugs with GABAergic activity for dopamine delivery in the brain.
Sara Piccinonna; Concetta Pacifico; Maddalena Corsini; Nunzio Denora; Serena Fedi; Antonio Lopalco; Nicola Margiotta; Giovanni Natile
Dinuclear Pt(II)-bisphosphonate complexes: a scaffold for multinuclear or different oxidation state platinum drugs.
Adriana Trapani; Johannes Sitterberg; Udo Bakowsky; Nunzio Denora; Giuliano Iacobellis; Thomas Kissel
Methotrexate-loaded chitosan- and glycol chitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors.

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All Publications

2012: Nunzio Denora; Andrea Giuffrida; Leonardo Laconca; Valentino Laquintana; Antonio Lopalco; Adriana Trapani; Tommaso Cassano; Concetta Stefania Cimmino; Giuseppe Trapani
Novel codrugs with GABAergic activity for dopamine delivery in the brain.
International journal of pharmaceutics 2012;437(1-2):221-31.
2012: Sara Piccinonna; Concetta Pacifico; Maddalena Corsini; Nunzio Denora; Serena Fedi; Antonio Lopalco; Nicola Margiotta; Giovanni Natile
Dinuclear Pt(II)-bisphosphonate complexes: a scaffold for multinuclear or different oxidation state platinum drugs.
Dalton transactions (Cambridge, England : 2003) 2012;41(32):9689-99.
2011: Adriana Trapani; Johannes Sitterberg; Udo Bakowsky; Nunzio Denora; Giuliano Iacobellis; Thomas Kissel
Methotrexate-loaded chitosan- and glycol chitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors.
AAPS PharmSciTech 2011;12(4):1302-11.
2011: Annalisa Cutrignelli; Nunzio Denora; Massimo Franco; Valentino Laquintana; Angela Lopedota; Delia Mandracchia; Adriana Trapani; Giuseppe Trapani
Griseofulvin/carrier blends: application of partial least squares (PLS) regression analysis for estimating the factors affecting the dissolution efficiency.
AAPS PharmSciTech 2011;12(4):1019-30.
2011: Nunzio Denora; Valentino Laquintana; Makoto Sawada; Hiromi Suzuki; Adriana Trapani; Giuseppe Trapani
New fluorescent probes targeting the mitochondrial-located translocator protein 18 kDa (TSPO) as activated microglia imaging agents.
Pharmaceutical research 2011;28(11):2820-32.
2011: Adriana Trapani; Gennaro Agrimi; Damiana Cafagna; Tommaso Cassano; Vincenzo Cuomo; Elvira De Giglio; Nunzio Denora; Silvana Gaetani; Giuseppe Trapani
Characterization and evaluation of chitosan nanoparticles for dopamine brain delivery.
International journal of pharmaceutics 2011;419(1-2):296-307.
2010: Nunzio Denora; Valentino Laquintana; Adriana Trapani; Angela Lopedota; Andrea Latrofa; James M Gallo; Giuseppe Trapani
Translocator protein (TSPO) ligand-Ara-C (cytarabine) conjugates as a strategy to deliver antineoplastic drugs and to enhance drug clinical potential.
Molecular pharmaceutics 2010;7(6):2255-69.
2010: Nicola Margiotta; Nunzio Denora; Rosa Ostuni; Valentino Laquintana; Amy Anderson; Steven W Johnson; Giuseppe Trapani; Giovanni Natile
Platinum(II) complexes with bioactive carrier ligands having high affinity for the translocator protein.
Journal of medicinal chemistry 2010;53(14):5144-54.
2009: Valentino Laquintana; Adriana Trapani; Nunzio Denora; Fan Wang; James M Gallo; Giuseppe Trapani
New strategies to deliver anticancer drugs to brain tumors.
Expert opinion on drug delivery 2009;6(10):1017-32.
2009: Valentino Laquintana; Nunzio Denora; Tiziana Musacchio; Massimo Lasorsa; Andrea Latrofa; Giuseppe Trapani
Peripheral benzodiazepine receptor ligand-PLGA polymer conjugates potentially useful as delivery systems of apoptotic agents.
Journal of controlled release : official journal of the Controlled Release Society 2009;137(3):185-95.
2009: Nunzio Denora; Adriana Trapani; Valentino Laquintana; Angela Lopedota; Giuseppe Trapani
Recent advances in medicinal chemistry and pharmaceutical technology--strategies for drug delivery to the brain.
Current topics in medicinal chemistry 2009;9(2):182-96.
2008: Nunzio Denora; Valentino Laquintana; Maria Giuseppina Pisu; Riccardo Dore; Luca Murru; Andrea Latrofa; Giuseppe Trapani; Enrico Sanna
2-Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity and electrophysiological studies.
Journal of medicinal chemistry 2008;51(21):6876-88.
2008: Annalisa Cutrignelli; Angela Lopedota; Adriana Trapani; Giancarlo Boghetich; Massimo Franco; Nunzio Denora; Valentino Laquintana; Giuseppe Trapani
Relationship between dissolution efficiency of Oxazepam/carrier blends and drug and carrier molecular descriptors using multivariate regression analysis.
International journal of pharmaceutics 2008;358(1-2):60-8.
2008: Katsuhiko Sekimata; Kentaro Hatano; Mikako Ogawa; Junichiro Abe; Yasuhiro Magata; Giovanni Biggio; Mariangela Serra; Valentino Laquintana; Nunzio Denora; Andrea Latrofa; Giuseppe Trapani; Gaetano Liso; Kengo Ito
Radiosynthesis and in vivo evaluation of N-[11C]methylated imidazopyridineacetamides as PET tracers for peripheral benzodiazepine receptors.
Nuclear medicine and biology 2008;35(3):327-34.
2007: Valentino Laquintana; Nunzio Denora; Angela Lopedota; Hiromi Suzuki; Makoto Sawada; Mariangela Serra; Giovanni Biggio; Andrea Latrofa; Giuseppe Trapani; Gaetano Liso
N-benzyl-2-(6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N-(6-(7-nitrobenzo[c][1,2,5]oxadiazol-4-ylamino)hexyl)acetamide as a new fluorescent probe for peripheral benzodiazepine receptor and microglial cell visualization.
Bioconjugate chemistry 2007;18(5):1397-407.
2007: Nunzio Denora; Barbara C M Potts; Valentino J Stella
A mechanistic and kinetic study of the beta-lactone hydrolysis of Salinosporamide A (NPI-0052), a novel proteasome inhibitor.
Journal of pharmaceutical sciences 2007;96(8):2037-47.
2007: Nunzio Denora; Valentino Laquintana; Angela Lopedota; Mariangela Serra; Laura Dazzi; Giovanni Biggio; Dhananjay Pal; Laura jane Jolliffe; Andrea Latrofa; Giuseppe Trapani; Gaetano Liso
Novel L-Dopa and dopamine prodrugs containing a 2-phenyl-imidazopyridine moiety.
Pharmaceutical research 2007;24(7):1309-24.
2007: Angela Lopedota; Annalisa Cutrignelli; Adriana Trapani; Giancarlo Boghetich; Nunzio Denora; Valentino Laquintana; Giuseppe Trapani; Gaetano Liso
Effects of different cyclodextrins on the morphology, loading and release properties of poly (DL-lactide-co-glycolide)-microparticles containing the hypnotic agent etizolam.
Journal of microencapsulation 2007;24(3):214-24.
2007: Nicola Margiotta; Rosa Ostuni; Rosa Ranaldo; Nunzio Denora; Valentino Laquintana; Giuseppe Trapani; Gaetano Liso; Giovanni Natile
Synthesis and characterization of a platinum(II) complex tethered to a ligand of the peripheral benzodiazepine receptor.
Journal of medicinal chemistry 2007;50(5):1019-27.
2007: Annalisa Cutrignelli; Nunzio Denora; Angela Lopedota; Adriana Trapani; Valentino Laquintana; Andrea Latrofa; Giuseppe Trapani; Gaetano Liso
Comparative effects of some hydrophilic excipients on the rate of gabapentin and baclofen lactamization in lyophilized formulations.
International journal of pharmaceutics 2007;332(1-2):98-106.
2007: Adriana Trapani; Valentino Laquintana; Nunzio Denora; Angela Lopedota; Annalisa Cutrignelli; Massimo Franco; Giuseppe Trapani; Gaetano Liso
Eudragit RS 100 microparticles containing 2-hydroxypropyl-beta-cyclodextrin and glutathione: physicochemical characterization, drug release and transport studies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2007;30(1):64-74.
2005: Adriana Trapani; Angela Lopedota; Nunzio Denora; Valentino Laquintana; Massimo Franco; Andrea Latrofa; Giuseppe Trapani; Gaetano Liso
A rapid screening tool for estimating the potential of 2-hydroxypropyl-beta-cyclodextrin complexation for solubilization purposes.
International journal of pharmaceutics 2005;295(1-2):163-75.
2005: Giuseppe Trapani; Valentino Laquintana; Nunzio Denora; Adriana Trapani; Angela Lopedota; Andrea Latrofa; Massimo Franco; Mariangela Serra; Maria Giuseppina Pisu; Ivan Floris; Enrico Sanna; Giovanni Biggio; Gaetano Liso
Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands.
Journal of medicinal chemistry 2005;48(1):292-305.