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Paul Dent

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Girija Dasmahapatra; Paul Dent; Richard I Fisher; Jonathan Friedberg; Hiral Patel; Steven Grant
The Bruton tyrosine kinase (BTK) inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse large-B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib.
Shibu Thomas; Xiang-Yang Wang; Swadesh K Das; Santanu Dasgupta; Rupesh Dash; Paul Dent; Luni Emdad; Maurizio Pellecchia; Bridget A Quinn; John C Reed; Devanand Sarkar; Paul B Fisher
Targeting the Bcl-2 family for cancer therapy.
Laurence Booth; Ching-Shih Chen; Nichola Cruickshanks; Steven Grant; Thomas Ridder; Paul Dent
OSU-03012 interacts with lapatinib to kill brain cancer cells.

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All Publications

2013: Girija Dasmahapatra; Paul Dent; Richard I Fisher; Jonathan Friedberg; Hiral Patel; Steven Grant
The Bruton tyrosine kinase (BTK) inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse large-B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib.
British journal of haematology 2013;161(1):43-56.
2013: Shibu Thomas; Xiang-Yang Wang; Swadesh K Das; Santanu Dasgupta; Rupesh Dash; Paul Dent; Luni Emdad; Maurizio Pellecchia; Bridget A Quinn; John C Reed; Devanand Sarkar; Paul B Fisher
Targeting the Bcl-2 family for cancer therapy.
Expert opinion on therapeutic targets 2013;17(1):61-75.
2012: Laurence Booth; Ching-Shih Chen; Nichola Cruickshanks; Steven Grant; Thomas Ridder; Paul Dent
OSU-03012 interacts with lapatinib to kill brain cancer cells.
Cancer biology & therapy 2012;13(14):1501-11.
2012: Nichola Cruickshanks; Steven Grant; Hossein Hamed; Yong Tang; Laurence Booth; Paul Dent
Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress.
Molecular pharmacology 2012;82(6):1217-29.
2012: Alae Yaseen; Stefanie Hock; Roberto Rosato; Shuang Chen; Yun Dai; Paul Dent; Steven Grant
Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway.
Molecular pharmacology 2012;82(6):1030-41.
2012: Shuang Chen; Yun Dai; Paul Dent; Mandy Garnett; Lora B Kramer; Dustin G Larsen; Jennifer Myers; Robert Z Orlowski; Xin-Yan Pei; Justin D Richey; Daniella M Schwartz; Gary L Simmons; Florence Su; Li Wang; Steven Grant
CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.
Cancer research 2012;72(16):4225-37.
2012: Yong Tang; Yun Dai; Steven Grant; Hossein A Hamed; Andrew Poklepovic; Paul Dent
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors.
Molecular pharmacology 2012;82(2):322-32.
2012: M Danielle Bareford; Nichola Cruickshanks; Jeremy C Allegood; Steven Grant; Hossein A Hamed; Besim Ogretmen; Margaret A Park; Andrew Poklepovic; Sarah Spiegel; Paul Dent
Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling.
Cancer biology & therapy 2012;13(9):793-803.
2012: Girija Dasmahapatra; Paul Dent; Richard I Fisher; Jonathan W Friedberg; Dmitry Lembersky; Hiral Patel; Derick Peterson; Minkyeong P Son; Elisa Attkisson; Steven Grant
Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo.
Molecular cancer therapeutics 2012;11(5):1122-32.
2012: Yong Tang; Gary Tye; Adly Yacoub; Steven Grant; Hossein A Hamed; Andrew Poklepovic; Paul Dent
Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells.
Cancer biology & therapy 2012;13(7):567-74.
2012: Nichola Cruickshanks; M Danielle Bareford; Paul B Fisher; Steven Grant; Hossein A Hamed; Andrew Poklepovic; Paul Dent
Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1.
Molecular pharmacology 2012;81(5):748-58.
2012: Belal Azab; Sujit K Bhutia; David T Curiel; Swadesh K Das; Rupesh Dash; Paul Dent; Igor P Dmitriev; Steven Grant; Michael Hedvat; Maurizio Pellecchia; Bridget A Quinn; John C Reed; Devanand Sarkar; Siddik Sarkar; Xue-Ning Shen; Xiang-Yang Wang; Paul B Fisher
Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells.
Journal of cellular physiology 2012;227(5):2145-53.
2012: Sujit K Bhutia; David T Curiel; Swadesh K Das; Rupesh Dash; Paul Dent; Steven Grant; Timothy P Kegelman; Seok-Geun Lee; Federica Rizzi; Devanand Sarkar; Zhao-Zhong Su; Xiang-Yang Wang; Belal Azab; Saverio Bettuzzi; Paul B Fisher
mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer.
Journal of cellular physiology 2012;227(5):1805-13.
2012: Luni Emdad; Paul Dent; Devanand Sarkar; Paul B Fisher
Future approaches for the therapy of malignant glioma: targeting genes mediating invasion.
Future oncology (London, England) 2012;8(4):343-6.
2012: Yong Tang; Steven Grant; Yun Dai; Paul Dent
Enhancing CHK1 inhibitor lethality in glioblastoma.
Cancer biology & therapy 2012;13(6):379-88.
2012: Yong Tang; Nichola Cruickshanks; Paul B Fisher; Steven Grant; Hossein A Hamed; Paul Dent
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
Molecular pharmacology 2012;81(4):527-40.
2012: Roberto Rosato; Stefanie Hock; Yun Dai; Paul Dent; Steven Grant
LBH-589 (panobinostat) potentiates fludarabine anti-leukemic activity through a JNK- and XIAP-dependent mechanism.
Leukemia research 2012;36(4):491-8.
2012: Laurence Booth; Sophie C Cazanave; Ching-Shih Chen; Steven Grant; Hossein A Hamed; Besim Ogretmen; Adly Yacoub; Paul Dent
OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing.
Cancer biology & therapy 2012;13(4):224-36.
2012: Swadesh K Das; Rupesh Dash; Paul Dent; Devanand Sarkar; Siddik Sarkar; Xiang-Yang Wang; Paul B Fisher
Chapter One---Cancer terminator viruses and approaches for enhancing therapeutic outcomes.
Advances in cancer research 2012;115():1-38.
2011: Xin-Yan Pei; Yukie Takabatake; Leena E Youssefian; Lora B Kramer; Jorge A Almenara; Wesley W Bodie; Shuang Chen; Yun Dai; Paul Dent; Jessica Felthousen; Steven Grant
Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2.
Blood 2011;118(19):5189-200.
2011: Bridget A Quinn; Mohamed Rahmani; John C Reed; Devanand Sarkar; Siddik Sarkar; John L Stebbins; Jun Wei; Bainan Wu; Belal Azab; David T Curiel; Swadesh K Das; Santanu Dasgupta; Rupesh Dash; Paul Dent; Igor Dmitriev; Steven Grant; Michael Hedvat; Sachin Kumar; Regina A Oyesanya; Maurizio Pellecchia; Paul B Fisher
Targeting Mcl-1 for the therapy of cancer.
Expert opinion on investigational drugs 2011;20(10):1397-411.
2011: M Danielle Bareford; Matthew E Burow; Nichola Cruickshanks; Paul B Fisher; Steven Grant; Hossein A Hamed; Richard G Moran; Kenneth P Nephew; Yong Tang; Paul Dent
Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells.
Autophagy 2011;7(10):1261-2.
2011: Yun Dai; Paul Dent; Vanessa L Funk; Lora B Kramer; Xin-Yan Pei; Li Wang; Shuang Chen; Steven Grant
Disruption of IkappaB kinase (IKK)-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to histone deacetylase (HDAC) inhibitors.
The Journal of biological chemistry 2011;286(39):34036-50.
2011: Girija Dasmahapatra; Paul Dent; Richard I Fisher; Jonathan W Friedberg; Dmitry Lembersky; Minkyeong P Son; Elisa Attkisson; Steven Grant
Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo.
Molecular cancer therapeutics 2011;10(9):1686-97.
2011: Paul Dent; David T Curiel; Paul B Fisher
The potential of virus-based gene therapies for treatment of metastatic kidney cancer.
Expert review of anticancer therapy 2011;11(6):809-11.
2011: Rupesh Dash; Belal Azab; Bridget A Quinn; Xuening Shen; Xiang-Yang Wang; Swadesh K Das; Mohamed Rahmani; Jun Wei; Michael Hedvat; Paul Dent; Igor P Dmitriev; David T Curiel; Steven Grant; Bainan Wu; John L Stebbins; Maurizio Pellecchia; John C Reed; Devanand Sarkar; Paul B Fisher
Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(21):8785-90.
2011: Paul Dent; Yong Tang; Adly Yacoub; Yun Dai; Paul B Fisher; Steven Grant
CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle.
Molecular interventions 2011;11(2):133-40.
2011: Yun Dai; Paul Dent; Lora B Kramer; Xin-Yan Pei; Li Wang; Shuang Chen; Steven Grant
Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF-κB and Bim.
British journal of haematology 2011;153(2):222-35.
2011: Margaret A Park; Hossein A Hamed; Clint Mitchell; Nichola Cruickshanks; Rupesh Dash; Jeremy C Allegood; Igor P Dmitriev; Gary Tye; Besim Ogretmen; Sarah Spiegel; Adly Yacoub; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.
Molecular pharmacology 2011;79(3):368-80.
2011: Yun Dai; Shuang Chen; Rena Shah; Xin-Yan Pei; Li Wang; Jorge A Almenara; Lora B Kramer; Paul Dent; Steven Grant
Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo.
Blood 2011;117(6):1947-57.
2011: Sandrine Lépine; Jeremy C Allegood; Myung H Park; Paul Dent; Sheldon Milstien; Sarah Spiegel
Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy.
Cell death and differentiation 2011;18(2):350-61.
2011: Rupesh Dash; Belal Azab; Xue-Ning Shen; Upneet K Sokhi; Siddik Sarkar; Zhao-zhong Su; Xiang-Yang Wang; Pier Paolo Claudio; Paul Dent; Igor P Dmitriev; David T Curiel; Steven Grant; Devanand Sarkar; Paul B Fisher
Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinic.
Discovery medicine 2011;11(56):46-56.
2010: Patrick J Eulitt; Margaret A Park; Hamed Hossein; Nichola Cruikshanks; Chen Yang; Igor P Dmitriev; Adly Yacoub; David T Curiel; Paul B Fisher; Paul Dent
Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery.
Cancer biology & therapy 2010;10(12):1290-305.
2010: Mohamed Rahmani; Mandy Mayo; Rupesh Dash; Upneet Kaur Sokhi; Igor P Dmitriev; Devanand Sarkar; Paul Dent; David T Curiel; Paul B Fisher; Steven Grant
Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress.
Molecular pharmacology 2010;78(6):1096-104.
2010: Wentao Jia; Roger M Loria; Margaret A Park; Adly Yacoub; Paul Dent; Martin R Graf
The neuro-steroid, 5-androstene 3β,17α diol; induces endoplasmic reticulum stress and autophagy through PERK/eIF2α signaling in malignant glioma cells and transformed fibroblasts.
The international journal of biochemistry & cell biology 2010;42(12):2019-29.
2010: Miho Murakami; Hideyo Ugai; Minghui Wang; Natalya Belousova; Paul Dent; Paul B Fisher; Joel N Glasgow; Maaike Everts; David T Curiel
An adenoviral vector expressing human adenovirus 5 and 3 fiber proteins for targeting heterogeneous cell populations.
Virology 2010;407(2):196-205.
2010: Clint Mitchell; Adly Yacoub; Hamed Hossein; Aditi Pandya Martin; M Danielle Bareford; Patrick Eulitt; Chen Yang; Kenneth P Nephew; Paul Dent
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
Cancer biology & therapy 2010;10(9):903-17.
2010: Paul Dent; Adly Yacoub; Hossein A Hamed; Margaret A Park; Rupesh Dash; Sujit K Bhutia; Devanand Sarkar; Xiang-Yang Wang; Pankaj Gupta; Luni Emdad; Irina V Lebedeva; Moira Sauane; Zao-Zhong Su; Mohamed Rahmani; William C Broaddus; Harold F Young; Maciej S Lesniak; Steven Grant; David T Curiel; Paul B Fisher
The development of MDA-7/IL-24 as a cancer therapeutic.
Pharmacology & therapeutics 2010;128(2):375-84.
2010: Clint Mitchell; Margaret Park; Patrick Eulitt; Chen Yang; Adly Yacoub; Paul Dent
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.
Molecular pharmacology 2010;78(5):909-17.
2010: Anindita Das; David Durrant; Clint Mitchell; Eric Mayton; Nicholas N Hoke; Fadi Salloum; Margaret A Park; Ian Qureshi; Ray Lee; Paul Dent; Rakesh C Kukreja
Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):18202-7.
2010: Rupesh Dash; Sujit K Bhutia; Belal Azab; Zao-Zhong Su; Bridget A Quinn; Timothy P Kegelmen; Swadesh K Das; Keetae Kim; Seok-Geun Lee; Margaret A Park; Adly Yacoub; Mohammed Rahmani; Luni Emdad; Igor P Dmitriev; Xiang-Yang Wang; Devanand Sarkar; Steven Grant; Paul Dent; David T Curiel; Paul B Fisher
mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.
Cytokine & growth factor reviews 2010;21(5):381-91.
2010: Yun Dai; Monica L Guzman; Shuang Chen; Li Wang; Sin-Kei Yeung; Xin-Yan Pei; Paul Dent; Craig T Jordan; Steven Grant
The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.
British journal of haematology 2010;151(1):70-83.
2010: Paul Dent; Adly Yacoub; Hossein A Hamed; Margaret A Park; Rupesh Dash; Sujit K Bhutia; Devanand Sarkar; Pankaj Gupta; Luni Emdad; Irina V Lebedeva; Moira Sauane; Zao-Zhong Su; Mohamed Rahmani; William C Broaddus; Harold F Young; Maciej Lesniak; Steven Grant; David T Curiel; Paul B Fisher
MDA-7/IL-24 as a cancer therapeutic: from bench to bedside.
Anti-cancer drugs 2010;21(8):725-31.
2010: Margaret A Park; Roland Reinehr; Dieter Häussinger; Christina Voelkel Johnson; Besim Ogretmen; Adly Yacoub; Steven Grant; Paul Dent
Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells.
Molecular cancer therapeutics 2010;9(8):2220-31.
2010: Margaret A Park; Clint Mitchell; Guo Zhang; Adly Yacoub; Jeremy Allegood; Dieter Häussinger; Roland Reinehr; Andrew Larner; Sarah Spiegel; Paul B Fisher; Christina Voelkel-Johnson; Besim Ogretmen; Steven Grant; Paul Dent
Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.
Cancer research 2010;70(15):6313-24.
2010: Risheng Cao; Zhumei Xu Cronk; Weibin Zha; Lixin Sun; Xuan Wang; Youwen Fang; Elaine Studer; Huiping Zhou; William M Pandak; Paul Dent; Gregorio Gil; Phillip B Hylemon
Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway.
Journal of lipid research 2010;51(8):2234-44.
2010: R Dash; I Dmitriev; Zao-Zhong Su; S K Bhutia; B Azab; N Vozhilla; Adly Yacoub; Paul Dent; David T Curiel; Devanand Sarkar; Paul B Fisher
Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells.
Cancer gene therapy 2010;17(7):447-56.
2010: Girija Dasmahapatra; Dmitry Lembersky; Lora Kramer; Richard I Fisher; Jonathan Friedberg; Paul Dent; Steven Grant
The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo.
Blood 2010;115(22):4478-87.
2010: Hossein A Hamed; Adly Yacoub; Margaret A Park; Patrick J Eulitt; Rupesh Dash; Devanand Sarkar; Igor P Dmitriev; Maciej S Lesniak; Khalid Shah; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(6):1130-42.
2010: Teneille Walker; Clint Mitchell; Margaret A Park; Adly Yacoub; Mohamed Rahmani; Dieter Häussinger; Roland Reinehr; Christina Voelkel Johnson; Paul B Fisher; Steven Grant; Paul Dent
17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species.
Molecular cancer therapeutics 2010;9(5):1378-95.
2010: Sujit K Bhutia; Rupesh Dash; Swadesh K Das; Belal Azab; Zao-Zhong Su; Seok-Geun Lee; Steven Grant; Adly Yacoub; Paul Dent; David T Curiel; Devanand Sarkar; Paul B Fisher
Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24.
Cancer research 2010;70(9):3667-76.
2010: Hossein A Hamed; Adly Yacoub; Margaret A Park; Patrick Eulitt; Devanand Sarkar; Igor P Dimitrie; Ching-Shih Chen; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins.
Cancer biology & therapy 2010;9(7):526-36.
2010: Tri K Nguyen; Nicholas Jordan; Jonathan Friedberg; Richard I Fisher; Paul Dent; Steven Grant
Inhibition of MEK/ERK1/2 sensitizes lymphoma cells to sorafenib-induced apoptosis.
Leukemia research 2010;34(3):379-86.
2010: Moira Sauane; Zao-Zhong Su; Rupesh Dash; Xiang Liu; James S Norris; Devanand Sarkar; Seok-Geun Lee; Jeremy C Allegood; Paul Dent; Sarah Spiegel; Paul B Fisher
Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis.
Journal of cellular physiology 2010;222(3):546-55.
2010: Miho Murakami; Hideyo Ugai; Natalya Belousova; Alexander Pereboev; Paul Dent; Paul B Fisher; Maaike Everts; David T Curiel
Chimeric adenoviral vectors incorporating a fiber of human adenovirus 3 efficiently mediate gene transfer into prostate cancer cells.
The Prostate 2010;70(4):362-76.
2010: Adly Yacoub; Hossein A Hamed; Jeremy C Allegood; Clint Mitchell; Sarah Spiegel; Maciej S Lesniak; Besim Ogretmen; Rupesh Dash; Devanand Sarkar; William C Broaddus; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
Cancer research 2010;70(3):1120-9.
2010: Adly Yacoub; Renyan Liu; Margaret A Park; Hossein A Hamed; Rupesh Dash; Danielle N Schramm; Devanand Sarkar; Igor P Dimitriev; Jessica K Bell; Steven Grant; Nicholas P Farrell; David T Curiel; Paul B Fisher; Paul Dent
Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells.
Molecular pharmacology 2010;77(2):298-310.
2010: Regina A Oyesanya; Susie Greenbaum; David Dang; Zendra Lee; Abir Mukherjee; Jinhua Wu; Paul Dent; Xianjun Fang
Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid.
Molecular cancer 2010;9():8.
2009: Paul Dent; David T Curiel; Steven Grant; Paul B Fisher
Minting a new class of polo-like-kinase inhibitors.
Cancer biology & therapy 2009;8(24):2384-5.
2009: Aditi Pandya Martin; Clint Mitchell; Mohamed Rahmani; Kenneth P Nephew; Steven Grant; Paul Dent
Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy.
Cancer biology & therapy 2009;8(21):2084-96.
2009: Dmitri Kapitonov; Jeremy C Allegood; Clint Mitchell; Nitai C Hait; Jorge A Almenara; Jeffrey K Adams; Robert E Zipkin; Paul Dent; Tomasz Kordula; Sheldon Milstien; Sarah Spiegel
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.
Cancer research 2009;69(17):6915-23.
2009: Aditi Pandya Martin; Margaret A Park; Clint Mitchell; Teneille Walker; Mohamed Rahmani; Andrew Thorburn; Dieter Häussinger; Roland Reinehr; Steven Grant; Paul Dent
BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.
Molecular pharmacology 2009;76(2):327-41.
2009: Teneille Walker; Clint Mitchell; Margaret A Park; Adly Yacoub; Martin Graf; Mohamed Rahmani; Peter J Houghton; Christina Voelkel Johnson; Steven Grant; Paul Dent
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
Molecular pharmacology 2009;76(2):342-55.
2009: Phillip B Hylemon; Huiping Zhou; William M Pandak; Shunlin Ren; Gregorio Gil; Paul Dent
Bile acids as regulatory molecules.
Journal of lipid research 2009;50(8):1509-20.
2009: Li Chen; Sirikalaya Jarujaron; Xudong Wu; Lixin Sun; Weibin Zha; Guang Liang; Xuan Wang; Emily C Gurley; Elaine Studer; Phillip B Hylemon; William M Pandak; Luyong Zhang; Guangji Wang; Xiaokun Li; Paul Dent; Huiping Zhou
HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages.
Biochemical pharmacology 2009;78(1):70-7.
2009: Martin R Graf; Wentao Jia; Ross S Johnson; Paul Dent; Clint Mitchell; Roger M Loria
Autophagy and the functional roles of Atg5 and beclin-1 in the anti-tumor effects of 3beta androstene 17alpha diol neuro-steroid on malignant glioma cells.
The Journal of steroid biochemistry and molecular biology 2009;115(3-5):137-45.
2009: Paul Dent; David T Curiel; Paul B Fisher; Steven Grant
Synergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2009;12(3):65-73.
2009: Tom Van Maerken; Devanand Sarkar; Frank Speleman; Paul Dent; William A Weiss; Paul B Fisher
Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma.
Journal of cellular physiology 2009;219(3):707-15.
2009: Margaret A Park; Teneille Walker; Aditi Pandya Martin; Jeremy C Allegood; Nicollaq Vozhilla; Luni Emdad; Devanand Sarkar; Mohamed Rahmani; Martin Graf; Adly Yacoub; Constantinos Koumenis; Sarah Spiegel; David T Curiel; Christina Voelkel Johnson; Steven Grant; Paul B Fisher; Paul Dent
MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.
Molecular cancer therapeutics 2009;8(5):1280-91.
2009: Girija Dasmahapatra; Dmitry Lembersky; Mohamed Rahmani; Lora Kramer; Jonathan Friedberg; Richard I Fisher; Paul Dent; Steven Grant
Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress.
Cancer biology & therapy 2009;8(9):808-19.
2009: Paul Dent; Steven Grant; Paul B Fisher; David T Curiel
PI3K: A rational target for ovarian cancer therapy?
Cancer biology & therapy 2009;8(1):27-30.
2008: Roberto R Rosato; Jorge A Almenara; Sonia C Maggio; Stefanie Coe; Peter Atadja; Paul Dent; Steven Grant
Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions.
Molecular cancer therapeutics 2008;7(10):3285-97.
2008: Margaret A Park; Guo Zhang; Aditi Pandya Martin; Hossein Hamed; Clint Mitchell; Phillip B Hylemon; Martin Graf; Mohamed Rahmani; Kevin Ryan; Xiang Liu; Sarah Spiegel; James Norris; Paul B Fisher; Steven Grant; Paul Dent
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.
Cancer biology & therapy 2008;7(10):1648-62.
2008: Margaret A Park; Guo Zhang; James Norris; Phillip B Hylemon; Paul B Fisher; Steven Grant; Paul Dent
Regulation of autophagy by ceramide-CD95-PERK signaling.
Autophagy 2008;4(7):929-31.
2008: Irina Lebedeva; Zao-Zhong Su; Nicolaq Vozhilla; Lejuan Chatman; Devanand Sarkar; Paul Dent; Mohammad Athar; Paul B Fisher
Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol.
Cancer research 2008;68(18):7439-47.
2008: Yun Dai; Shuang Chen; Xin-Yan Pei; Jorge A Almenara; Lora B Kramer; Charis A Venditti; Paul Dent; Steven Grant
Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells.
Blood 2008;112(6):2439-49.
2008: Guo Zhang; Margaret A Park; Clint Mitchell; Teneille Walker; Hossein Hamed; Elaine Studer; Martin Graf; Mohamed Rahmani; Seema Gupta; Phillip B Hylemon; Paul B Fisher; Steven Grant; Paul Dent
Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling.
The Journal of biological chemistry 2008;283(36):24343-58.
2008: Margaret A Park; Guo Zhang; Clint Mitchell; Mohamed Rahmani; Hossein Hamed; Michael P Hagan; Adly Yacoub; David T Curiel; Paul B Fisher; Steven Grant; Paul Dent
Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
Molecular cancer therapeutics 2008;7(9):2633-48.
2008: Guo Zhang; Margaret A Park; Clint Mitchell; Hossein Hamed; Mohamed Rahmani; Aditi Pandya Martin; David T Curiel; Adly Yacoub; Martin Graf; Ray Lee; John D Roberts; Paul B Fisher; Steven Grant; Paul Dent
Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(17):5385-99.
2008: Paul Dent; Adly Yacoub; Margaret Park; Devanand Sarkar; Khalid Shah; David T Curiel; Steven Grant; Paul B Fisher
Searching for a cure: gene therapy for glioblastoma.
Cancer biology & therapy 2008;7(9):1335-40.
2008: Aditi Pandya Martin; Anna Miller; Luni Emad; Mohamed Rahmani; Teneille Walker; Clint Mitchell; Michael P Hagan; Margaret A Park; Adly Yacoub; Paul B Fisher; Steven Grant; Paul Dent
Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation.
Molecular pharmacology 2008;74(3):807-22.
2008: Yun Dai; Shuang Chen; Charis A Venditti; Xin-Yan Pei; Tri K Nguyen; Paul Dent; Steven Grant
Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate.
Blood 2008;112(3):793-804.
2008: Regina A Oyesanya; Zendra P Lee; Jinhua Wu; Jing Chen; Yuanda Song; Abir Mukherjee; Paul Dent; Tomasz Kordula; Huiping Zhou; Xianjun Fang
Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(8):2639-51.
2008: Moira Sauane; Zao-Zhong Su; Pankaj Gupta; Irina Lebedeva; Paul Dent; Devanand Sarkar; Paul B Fisher
Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9763-8.
2008: Irina Lebedeva; Zao-Zhong Su; Nichollaq Vozhilla; Lejuan Chatman; Devanand Sarkar; Paul Dent; Mohammad Athar; Paul B Fisher
Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis.
Molecular cancer therapeutics 2008;7(7):2042-50.
2008: Yuko Tsuruta; Larisa Pereboeva; Martina Breidenbach; Daniel T Rein; Minghui Wang; Ronald D Alvarez; Gene P Siegal; Paul Dent; Paul B Fisher; David T Curiel
A fiber-modified mesothelin promoter-based conditionally replicating adenovirus for treatment of ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(11):3582-8.
2008: Adly Yacoub; Hossein Hamed; Luni Emdad; Wagner Dos Santos; Pankaj Gupta; William C Broaddus; Viswanathan Ramakrishnan; Devanand Sarkar; Khalid Shah; David T Curiel; Steven Grant; Paul B Fisher; Paul Dent
MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors.
Cancer biology & therapy 2008;7(6):917-33.
2008: Pankaj Gupta; Luni Emdad; Irina Lebedeva; Devanand Sarkar; Paul Dent; David T Curiel; Jeffrey Settleman; Paul B Fisher
Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva.
Journal of cellular physiology 2008;215(3):827-36.
2008: C P L Paul; Maaike Everts; Joel N Glasgow; Paul Dent; Paul B Fisher; Ilya V Ulasov; Maciej S. Lesniak; Mariam A Stoff-Khalili; Justin Roth; M A Preuss; C M F Dirven; M L M Lamfers; Gene P Siegal; Zeng B Zhu; David T Curiel
Characterization of infectivity of knob-modified adenoviral vectors in glioma.
Cancer biology & therapy 2008;7(5):786-93.
2008: Devanand Sarkar; Zao-Zhong Su; Eun Sook Park; Nicolaq Vozhilla; Paul Dent; David T Curiel; Paul B Fisher
A cancer terminator virus eradicates both primary and distant human melanomas.
Cancer gene therapy 2008;15(5):293-302.
2008: Margaret A Park; Adly Yacoub; Devanand Sarkar; Luni Emdad; Mohamed Rahmani; Sarah Spiegel; Constantinos Koumenis; Martin Graf; David T Curiel; Steven Grant; Paul B Fisher; Paul Dent
PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells.
Autophagy 2008;4(4):513-5.
2008: Hossein Hamed; Clint Mitchell; Margaret A Park; David Hanna; Aditi Pandya Martin; Benjamin Harrison; William Hawkins; David A Curiel; Paul B Fisher; Steven Grant; Adly Yacoub; Michael P Hagan; Paul Dent
Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo.
Cancer biology & therapy 2008;7(4):587-93.
2008: Margaret A Park; David T Curiel; Constantinos Koumenis; Martin Graf; Ching-Shih Chen; Paul B Fisher; Steven Grant; Paul Dent
PERK-dependent regulation of HSP70 expression and the regulation of autophagy.
Autophagy 2008;4(3):364-7.
2008: Margaret A Park; Adly Yacoub; Mohamed Rahmani; Guo Zhang; Lori Hart; Michael P Hagan; Stuart K Calderwood; Michael Y Sherman; Constantinos Koumenis; Sarah Spiegel; Ching-Shih Chen; Martin Graf; David T Curiel; Paul B Fisher; Steven Grant; Paul Dent
OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells.
Molecular pharmacology 2008;73(4):1168-84.
2008: Hossein Hamed; William Hawkins; Clint Mitchell; Donna Gilfor; Guo Zhang; Xin-Yan Pei; Yun Dai; Michael P Hagan; John D Roberts; Adly Yacoub; Steven Grant; Paul Dent
Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo.
Molecular cancer therapeutics 2008;7(3):616-29.
2008: Adly Yacoub; Pankaj Gupta; Margaret A Park; Mohammed Rhamani; Hossein Hamed; David Hanna; Guo Zhang; Devanand Sarkar; Irina Lebedeva; Luni Emdad; Constantinos Koumenis; David T Curiel; Steven Grant; Paul B Fisher; Paul Dent
Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling.
Molecular cancer therapeutics 2008;7(2):314-29.
2008: Adly Yacoub; Margaret A Park; Pankaj Gupta; Mohamed Rahmani; Guo Zhang; Hossein Hamed; David Hanna; Devanand Sarkar; Irina Lebedeva; Luni Emdad; Moira Sauane; Nicollaq Vozhilla; Sarah Spiegel; Constantinos Koumenis; Martin Graf; David T Curiel; Steven Grant; Paul B Fisher; Paul Dent
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.
Molecular cancer therapeutics 2008;7(2):297-313.
2008: Yun Dai; Shuang Chen; Lora B Kramer; Vanessa L Funk; Paul Dent; Steven Grant
Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):549-58.
2008: Devanand Sarkar; Paul Dent; David T Curiel; Paul B Fisher
Acquired and innate resistance to the cancer-specific apoptosis-inducing cytokine, mda-7/IL-24: not insurmountable therapeutic problems.
Cancer biology & therapy 2008;7(1):109-12.
2007: Clint Mitchell; Margaret A Park; Guo Zhang; Adly Yacoub; David T Curiel; Paul B Fisher; John D Roberts; Steven Grant; Paul Dent
Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.
Molecular cancer therapeutics 2007;6(12 Pt 1):3101-12.
2007: Luni Emdad; Irina Lebedeva; Zao-Zhong Su; Devanand Sarkar; Paul Dent; David T Curiel; Paul B Fisher
Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells.
Molecular cancer therapeutics 2007;6(11):2985-94.
2007: Heidi Sankala; Nitai C Hait; Steven W Paugh; Dai Shida; Sandrine Lépine; Lynne W Elmore; Paul Dent; Sheldon Milstien; Sarah Spiegel
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin.
Cancer research 2007;67(21):10466-74.
2007: Paul B Fisher; Devanand Sarkar; Irina Lebedeva; Luni Emdad; Pankaj Gupta; Moira Sauane; Zao-Zhong Su; Steven Grant; Paul Dent; David T Curiel; Neil Senzer; John Nemunaitis
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma.
Toxicology and applied pharmacology 2007;224(3):300-7.
2007: Xin-Yan Pei; Yun Dai; Sarah Tenorio; Jianghua Lu; Hisashi Harada; Paul Dent; Steven Grant
MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.
Blood 2007;110(6):2092-101.
2007: Mohamed Rahmani; Tri K Nguyen; Paul Dent; Steven Grant
The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation.
Molecular pharmacology 2007;72(3):788-95.
2007: Clint Mitchell; Peyman Kabolizadeh; John Ryan; John D Roberts; Adly Yacoub; David T Curiel; Paul B Fisher; Michael P Hagan; Nicholas Farrell; Steven Grant; Paul Dent
Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling.
Molecular pharmacology 2007;72(3):704-14.
2007: Michael P Hagan; Adly Yacoub; Paul Dent
Radiation-induced PARP activation is enhanced through EGFR-ERK signaling.
Journal of cellular biochemistry 2007;101(6):1384-93.
2007: Mohamed Rahmani; Eric Maynard Davis; Timothy Ryan Crabtree; Joseph Reza Habibi; Tri K Nguyen; Paul Dent; Steven Grant
The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress.
Molecular and cellular biology 2007;27(15):5499-513.
2007: Girija Dasmahapatra; Nitin Yerram; Yun Dai; Paul Dent; Steven Grant
Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(14):4280-90.
2007: Steven Grant; Paul Dent
Simultaneous interruption of signal transduction and cell cycle regulatory pathways: implications for new approaches to the treatment of childhood leukemias.
Current drug targets 2007;8(6):751-9.
2007: Devanand Sarkar; Irina Lebedeva; Zao-Zhong Su; Eun Sook Park; Lejuan Chatman; Nicolaq Vozhilla; Paul Dent; David T Curiel; Paul B Fisher
Eradication of therapy-resistant human prostate tumors using a cancer terminator virus.
Cancer research 2007;67(11):5434-42.
2007: Yun Dai; Payal Khanna; Shuang Chen; Xin-Yan Pei; Paul Dent; Steven Grant
Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.
Blood 2007;109(10):4415-23.
2007: Devanand Sarkar; Irina Lebedeva; Pankaj Gupta; Luni Emdad; Moira Sauane; Paul Dent; David T Curiel; Paul B Fisher
Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?
Expert opinion on biological therapy 2007;7(5):577-86.
2007: Yuko Tsuruta; Larisa Pereboeva; Joel N Glasgow; Daniel T Rein; Yosuke Kawakami; Ronald D Alvarez; Rodney P Rocconi; Gene P Siegal; Paul Dent; Paul B Fisher; David T Curiel
A mosaic fiber adenovirus serotype 5 vector containing reovirus sigma 1 and adenovirus serotype 3 knob fibers increases transduction in an ovarian cancer ex vivo system via a coxsackie and adenovirus receptor-independent pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(9):2777-83.
2007: Tri K Nguyen; Mohamed Rahmani; Hisashi Harada; Paul Dent; Steven Grant
MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825.
Blood 2007;109(9):4006-15.
2007: Youwen Fang; Elaine Studer; Clint Mitchell; Steven Grant; William M Pandak; Phillip B Hylemon; Paul Dent
Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.
Molecular pharmacology 2007;71(4):1122-8.
2007: Kristoffer Valerie; Adly Yacoub; Michael P Hagan; David T Curiel; Paul B Fisher; Steven Grant; Paul Dent
Radiation-induced cell signaling: inside-out and outside-in.
Molecular cancer therapeutics 2007;6(3):789-801.
2007: Irina Lebedeva; Ilyas Washington; Devanand Sarkar; Jennifer A Clark; Robert L Fine; Paul Dent; David T Curiel; Nicholas J Turro; Paul B Fisher
Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3484-9.
2007: Roberto R Rosato; Jorge A Almenara; Sarah S Kolla; Sonia C Maggio; Stefanie Coe; Maria S Giménez; Paul Dent; Steven Grant
Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions.
Molecular cancer therapeutics 2007;6(2):692-702.
2007: Clint Mitchell; Margaret A Park; Guo Zhang; Song Iy Han; Hisashi Harada; Richard A Franklin; Adly Yacoub; Pin-Lan Li; Phillip B Hylemon; Steven Grant; Paul Dent
17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines.
Molecular cancer therapeutics 2007;6(2):618-32.
2007: Sarah E Golding; Elizabeth Rosenberg; Steven Neill; Paul Dent; Lawrence F Povirk; Kristoffer Valerie
Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response.
Cancer research 2007;67(3):1046-53.
2007: Shuang Chen; Yun Dai; Hisashi Harada; Paul Dent; Steven Grant
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.
Cancer research 2007;67(2):782-91.
2007: Paul Dent; Philip B Hylemon; Steven Grant; Paul B Fisher
Approaches for monitoring signal transduction changes in normal and cancer cells.
Methods in molecular biology (Clifton, N.J.) 2007;383():259-76.
2007: Adly Yacoub; William Hawkins; David Hanna; Hong Young; Margaret A Park; Mark Grant; John D Roberts; David T Curiel; Paul B Fisher; Kristoffer Valerie; Steven Grant; Michael P Hagan; Paul Dent
Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment.
Molecular pharmacology 2007;71(1):259-75.
2006: Adly Yacoub; Anna Miller; Ruben Caron; Liang Qiao; David A Curiel; Paul B Fisher; Michael P Hagan; Steven Grant; Paul Dent
Radiotherapy-induced signal transduction.
Endocrine-related cancer 2006;13 Suppl 1():S99-114.
2006: Xin-Yan Pei; Weiqun Li; Yun Dai; Paul Dent; Steven Grant
Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells.
Molecular pharmacology 2006;70(6):1965-73.
2006: L Lin; Z Su; Irina Lebedeva; Pankaj Gupta; Habib Boukerche; T Rai; Glen N Barber; Paul Dent; Devanand Sarkar; Paul B Fisher
Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis.
Cell death and differentiation 2006;13(11):1982-93.
2006: Adly Yacoub; Donna Gilfor; William Hawkins; Margaret A Park; David Hanna; Michael P Hagan; David T Curiel; Paul B Fisher; Steven Grant; Paul Dent
MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo.
Cancer biology & therapy 2006;5(10):1332-9.
2006: Girija Dasmahapatra; Tri K Nguyen; Paul Dent; Steven Grant
Adaphostin and bortezomib induce oxidative injury and apoptosis in imatinib mesylate-resistant hematopoietic cells expressing mutant forms of Bcr/Abl.
Leukemia research 2006;30(10):1263-72.
2006: Pankaj Gupta; Zao-Zhong Su; Irina Lebedeva; Devanand Sarkar; Moira Sauane; Luni Emdad; Michael A Bachelor; Steven Grant; David T Curiel; Paul Dent; Paul B Fisher
mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine.
Pharmacology & therapeutics 2006;111(3):596-628.
2006: Ning Gao; Lora Kramer; Mohamed Rahmani; Paul Dent; Steven Grant
The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism.
Molecular pharmacology 2006;70(2):645-55.
2006: Luni Emdad; Devanand Sarkar; Irina Lebedeva; Zao-Zhong Su; Pankaj Gupta; Parameshwar J Mahasreshti; Paul Dent; David T Curiel; Paul B Fisher
Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer.
Journal of cellular physiology 2006;208(2):298-306.
2006: Adly Yacoub; Margaret A Park; David Hanna; Young Hong; Clint Mitchell; Aditi P Pandya; Hisashi Harada; Garth Powis; Ching-Shih Chen; Constantinos Koumenis; Steven Grant; Paul Dent
OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells.
Molecular pharmacology 2006;70(2):589-603.
2006: Zao-Zhong Su; Irina Lebedeva; Devanand Sarkar; Luni Emdad; Pankaj Gupta; Shinichi Kitada; Paul Dent; John C Reed; Paul B Fisher
Ionizing radiation enhances therapeutic activity of mda-7/IL-24: overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2.
Oncogene 2006;25(16):2339-48.
2006: Tri K Nguyen; Mohamed Rahmani; Ning Gao; Lora Kramer; Amie S Corbin; Brian J Druker; Paul Dent; Steven Grant
Synergistic interactions between DMAG and mitogen-activated protein kinase kinase 1/2 inhibitors in Bcr/abl+ leukemia cells sensitive and resistant to imatinib mesylate.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 1):2239-47.
2006: Parameshwar J Mahasreshti; Manjula Kataram; Hongju Wu; Laxmi Priya Yalavarthy; Delicia Carey; Paul B Fisher; Sunil Chada; Ronald D Alvarez; Hidde J Haisma; Paul Dent; David T Curiel
Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy.
Gynecologic oncology 2006;100(3):521-32.
2006: Irina Lebedeva; Devanand Sarkar; Zao-Zhong Su; Rahul V Gopalkrishnan; Mohammad Athar; Aaron Randolph; Kristoffer Valerie; Paul Dent; Paul B Fisher
Molecular target-based therapy of pancreatic cancer.
Cancer research 2006;66(4):2403-13.
2006: Yun Dai; Tracy E Hamm; Paul Dent; Steven Grant
Cyclin D1 overexpression increases the susceptibility of human U266 myeloma cells to CDK inhibitors through a process involving p130-, p107- and E2F-dependent S phase entry.
Cell cycle (Georgetown, Tex.) 2006;5(4):437-46.
2006: Roberto R Rosato; Sonia C Maggio; Jorge A Almenara; Shawn G Payne; Peter Atadja; Sarah Spiegel; Paul Dent; Steven Grant
The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide.
Molecular pharmacology 2006;69(1):216-25.
2006: Girija Dasmahapatra; Mohamed Rahmani; Paul Dent; Steven Grant
The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism.
Blood 2006;107(1):232-40.
2006: Ning Gao; Mohamed Rahmani; Xianglin Shi; Paul Dent; Steven Grant
Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress.
Blood 2006;107(1):241-9.
2005: Paul Dent; Youwen Fang; Seema Gupta; Elaine Studer; Clint Mitchell; Sarah Spiegel; Phillip B Hylemon
Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.
Hepatology (Baltimore, Md.) 2005;42(6):1291-9.
2005: Paul Dent; Song Iy Han; Clint Mitchell; Elaine Studer; Adly Yacoub; Jennifer Rubin Grandis; Steven Grant; Geoffrey W Krystal; Phillip B Hylemon
Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.
Biochemical pharmacology 2005;70(11):1685-96.
2005: Zhaozhong Su; Luni Emdad; Moira Sauane; Irina Lebedeva; Devanand Sarkar; Pankaj Gupta; C David James; Aaron Randolph; Kristoffer Valerie; Mark R Walter; Paul Dent; Paul B Fisher
Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells.
Oncogene 2005;24(51):7552-66.
2005: William Hawkins; Clint Mitchell; Robert McKinstry; Donna Gilfor; James Starkey; Yun Dai; Kathy Dawson; Viswanathan Ramakrishnan; John D Roberts; Adly Yacoub; Steven Grant; Paul Dent
Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth.
Cancer biology & therapy 2005;4(11):1275-84.
2005: Roberto R Rosato; Jorge A Almenara; Sonia C Maggio; Peter Atadja; Ruth Craig; Julie Vrana; Paul Dent; Steven Grant
Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells.
Molecular cancer therapeutics 2005;4(11):1772-85.
2005: Mohamed Rahmani; Eric Maynard Davis; Cheryl Bauer; Paul Dent; Steven Grant
Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation.
The Journal of biological chemistry 2005;280(42):35217-27.
2005: Chunrong Yu; Girija Dasmahapatra; Paul Dent; Steven Grant
Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells.
Leukemia 2005;19(9):1579-89.
2005: Yun Dai; Mohamed Rahmani; Paul Dent; Steven Grant
Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation.
Molecular and cellular biology 2005;25(13):5429-44.
2005: Paul Dent; Adly Yacoub; Steven Grant; David T Curiel; Paul B Fisher
MDA-7/IL-24 regulates proliferation, invasion and tumor cell radiosensitivity: a new cancer therapy?
Journal of cellular biochemistry 2005;95(4):712-9.
2005: Xin-Yan Pei; Yun Dai; Mohamed Rahmani; Weiqun Li; Paul Dent; Steven Grant
The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(12):4589-600.
2005: Ning Gao; Mohamed Rahmani; Paul Dent; Steven Grant
2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process.
Oncogene 2005;24(23):3797-809.
2005: Paul Dent; Adly Yacoub; Steven Grant
DMC: novel celecoxib derivatives to rap cancer.
Cancer biology & therapy 2005;4(5):583-4.
2005: Mohamed Rahmani; Erin Reese; Yun Dai; Cheryl Bauer; Lora B Kramer; Mei Huang; Richard Jove; Paul Dent; Steven Grant
Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change.
Molecular pharmacology 2005;67(4):1166-76.
2005: Zao-Zhong Su; Luni Emdad; Devanand Sarkar; Aaron Randolph; Kristoffer Valerie; Adly Yacoub; Paul Dent; Paul B Fisher
Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3).
Oncogene 2005;24(13):2247-55.
2005: Mohamed Rahmani; Erin Reese; Yun Dai; Cheryl Bauer; Shawn G Payne; Paul Dent; Sarah Spiegel; Steven Grant
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.
Cancer research 2005;65(6):2422-32.
2005: Michael Hahn; Weiqun Li; Chunrong Yu; Mohamed Rahmani; Paul Dent; Steven Grant
Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
Molecular cancer therapeutics 2005;4(3):457-70.
2005: Rubén W Carón; Adly Yacoub; Clint Mitchell; Xiaoyu Zhu; Young Hong; Takehiko Sasazuki; Senji Shirasawa; Michael P Hagan; Steven Grant; Paul Dent
Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.
Cell cycle (Georgetown, Tex.) 2005;4(3):456-64.
2005: Yun Dai; Mohamed Rahmani; Xin-Yan Pei; Payal Khanna; Song Iy Han; Clint Mitchell; Paul Dent; Steven Grant
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
Blood 2005;105(4):1706-16.
2005: Rubén W Carón; Adly Yacoub; Min Li; Xiaoyu Zhu; Clint Mitchell; Young Hong; William Hawkins; Takehiko Sasazuki; Senji Shirasawa; Alan P Kozikowski; Philip A Dennis; Michael P Hagan; Steven Grant; Paul Dent
Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.
Molecular cancer therapeutics 2005;4(2):257-70.
2005: Rubén W Carón; Adly Yacoub; Xiaoyu Zhu; Clint Mitchell; Song Iy Han; Takehiko Sasazuki; Senji Shirasawa; Michael P Hagan; Steven Grant; Paul Dent
H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.
Molecular cancer therapeutics 2005;4(2):243-55.
2005: Irina Lebedeva; Zao-Zhong Su; Devanand Sarkar; Rahul V Gopalkrishnan; Samuel Waxman; Adly Yacoub; Paul Dent; Paul B Fisher
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Oncogene 2005;24(4):585-96.
2005: Irina Lebedeva; Moira Sauane; Rahul V Gopalkrishnan; Devanand Sarkar; Zao-Zhong Su; Pankaj Gupta; John Nemunaitis; Casey Cunningham; Adly Yacoub; Paul Dent; Paul B Fisher
mda-7/IL-24: exploiting cancer's Achilles' heel.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(1):4-18.
2004: Paul Dent; Steven Grant
Irofulven: resurgence for alkylating therapy in cancer?
Cancer biology & therapy 2004;3(11):1143-4.
2004: Moira Sauane; Rahul V Gopalkrishnan; Heng-Tong Choo; Pankaj Gupta; Irina Lebedeva; Adly Yacoub; Paul Dent; Paul B Fisher
Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein.
Oncogene 2004;23(46):7679-90.
2004: Wesam Ahmed; Mohamed Rahmani; Paul Dent; Steven Grant
The cyclin-dependent kinase inhibitor p21(CIP1/WAF1) blocks paclitaxel-induced G2M arrest and attenuates mitochondrial injury and apoptosis in p53-null human leukemia cells.
Cell cycle (Georgetown, Tex.) 2004;3(10):1305-11.
2004: Youwen Fang; Song Iy Han; Clint Mitchell; Seema Gupta; Elaine Studer; Steven Grant; Phillip B Hylemon; Paul Dent
Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes.
Hepatology (Baltimore, Md.) 2004;40(4):961-71.
2004: Ning Gao; Yun Dai; Mohamed Rahmani; Paul Dent; Steven Grant
Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol.
Molecular pharmacology 2004;66(4):956-63.
2004: Michael P Hagan; Adly Yacoub; Paul Dent
Ionizing radiation causes a dose-dependent release of transforming growth factor alpha in vitro from irradiated xenografts and during palliative treatment of hormone-refractory prostate carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(17):5724-31.
2004: Yun Dai; Mohamed Rahmani; Seth J Corey; Paul Dent; Steven Grant
A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2.
The Journal of biological chemistry 2004;279(33):34227-39.
2004: Charles A Leath; Manjula Kataram; Pradeep Bhagavatula; Rahul V Gopalkrishnan; Paul Dent; Paul B Fisher; Alexander Pereboev; Delicia Carey; Irina Lebedeva; Hidde J Haisma; Ronald D Alvarez; David T Curiel; Parameshwar J Mahasreshti
Infectivity enhanced adenoviral-mediated mda-7/IL-24 gene therapy for ovarian carcinoma.
Gynecologic oncology 2004;94(2):352-62.
2004: Adly Yacoub; Clint Mitchell; Young Hong; Rahul V Gopalkrishnan; Zao-Zhong Su; Pankaj Gupta; Moria Sauane; Irina Lebedeva; David T Curiel; Parameshwar J Mahasreshti; Myrna R Rosenfeld; William C Broaddus; C David James; Steven Grant; Paul B Fisher; Paul Dent
MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells.
Cancer biology & therapy 2004;3(8):739-51.
2004: Yun Dai; Mohamed Rahmani; Xin-Yan Pei; Paul Dent; Steven Grant
Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms.
Blood 2004;104(2):509-18.
2004: Steven Grant; Paul Dent
Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: what's in a name?
Molecular cancer therapeutics 2004;3(7):873-5.
2004: Moira Sauane; Irina Lebedeva; Zao-Zhong Su; Heng-tong Choo; Aaron Randolph; Kristoffer Valerie; Paul Dent; Rahul V Gopalkrishnan; Paul B Fisher
Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways.
Cancer research 2004;64(9):2988-93.
2004: Chunrong Yu; Mohamed Rahmani; Paul Dent; Steven Grant
The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib.
Experimental cell research 2004;295(2):555-66.
2004: Yun Dai; Xin-Yan Pei; Mohamed Rahmani; Daniel H Conrad; Paul Dent; Steven Grant
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells.
Blood 2004;103(7):2761-70.
2004: Steven Grant; Paul Dent
Activation of MAP kinase pathways by TRAIL: don't expect the obvious.
Cancer biology & therapy 2004;3(3):302-4.
2004: Chunrong Yu; Mohamed Rahmani; Jorge A Almenara; Edward A Sausville; Paul Dent; Steven Grant
Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process.
Oncogene 2004;23(7):1364-76.
2004: Seema Gupta; Ramesh Natarajan; Shawn G Payne; Elaine Studer; Sarah Spiegel; Paul Dent; Phillip B Hylemon
Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation.
The Journal of biological chemistry 2004;279(7):5821-8.
2004: Song Iy Han; Elaine Studer; Seema Gupta; Youwen Fang; Liang Qiao; Weiqun Li; Steven Grant; Phillip B Hylemon; Paul Dent
Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes.
Hepatology (Baltimore, Md.) 2004;39(2):456-63.
2003: Mohamed Rahmani; Chunrong Yu; Yun Dai; Erin Reese; Wesam Ahmed; Paul Dent; Steven Grant
Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells.
Cancer research 2003;63(23):8420-7.
2003: Irina Lebedeva; Zao-Zhong Su; Devanand Sarkar; Shinichi Kitada; Paul Dent; Samuel Waxman; John C Reed; Paul B Fisher
Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species.
Cancer research 2003;63(23):8138-44.
2003: Yun Dai; Paul Dent; Steven Grant
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.
Molecular pharmacology 2003;64(6):1402-9.
2003: Irina Lebedeva; Devanand Sarkar; Zao-Zhong Su; Shinichi Kitada; Paul Dent; Cy A Stein; John C Reed; Paul B Fisher
Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24.
Oncogene 2003;22(54):8758-73.
2003: Chunrong Yu; Mohamed Rahmani; Daniel Conrad; Mark Subler; Paul Dent; Steven Grant
The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.
Blood 2003;102(10):3765-74.
2003: Adly Yacoub; Song Iy Han; Ruben Caron; Donna Gilfor; Susan Mooberry; Steven Grant; Paul Dent
Sequence dependent exposure of mammary carcinoma cells to Taxotere and the MEK1/2 inhibitor U0126 causes enhanced cell killing in vitro.
Cancer biology & therapy 2003;2(6):670-6.
2003: Mohamed Rahmani; Chunrong Yu; Erin Reese; Wesam Ahmed; Karen Hirsch; Paul Dent; Steven Grant
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition.
Oncogene 2003;22(40):6231-42.
2003: Chunrong Yu; Mark Subler; Mohamed Rahmani; Erin Reese; Geoffrey W Krystal; Daniel Conrad; Paul Dent; Steven Grant
Induction of apoptosis in BCR/ABL+ cells by histone deacetylase inhibitors involves reciprocal effects on the RAF/MEK/ERK and JNK pathways.
Cancer biology & therapy 2003;2(5):544-51.
2003: Paul Dent; Adly Yacoub; Paul B Fisher; Michael P Hagan; Steven Grant
MAPK pathways in radiation responses.
Oncogene 2003;22(37):5885-96.
2003: Wentao Jia; Chunrong Yu; Mohamed Rahmani; Geoffrey W Krystal; Edward A Sausville; Paul Dent; Steven Grant
Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.
Blood 2003;102(5):1824-32.
2003: Guido Lammering; Theodore H Hewit; Kristoffer Valerie; Joseph N Contessa; George P Amorino; Paul Dent; Rupert K Schmidt-Ullrich
EGFRvIII-mediated radioresistance through a strong cytoprotective response.
Oncogene 2003;22(36):5545-53.
2003: Adly Yacoub; Clint Mitchell; Andrea Lister; Irina Lebedeva; Devanand Sarkar; Zao-Zhong Su; Carter Sigmon; Robert McKinstry; Viswanathan Ramakrishnan; Liang Qiao; William C Broaddus; Rahul V Gopalkrishnan; Steven Grant; Paul B Fisher; Paul Dent
Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(9):3272-81.
2003: Moira Sauane; Rahul V Gopalkrishnan; Irina Lebedeva; Mei Xin Mei; Devanand Sarkar; Zao-Zhong Su; Dong-Chul Kang; Paul Dent; Sidney Pestka; Paul B Fisher
Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways.
Journal of cellular physiology 2003;196(2):334-45.
2003: Adly Yacoub; Clint Mitchell; Irina Lebedeva; Devanand Sarkar; Zao-Zhong Su; Robert McKinstry; Rahul V Gopalkrishnan; Steven Grant; Paul B Fisher; Paul Dent
mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling.
Cancer biology & therapy 2003;2(4):347-53.
2003: Paul B Fisher; Rahul V Gopalkrishnan; Sunil Chada; Rajagopal Ramesh; Elizabeth A Grimm; Myrna R Rosenfeld; David T Curiel; Paul Dent
mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic.
Cancer biology & therapy 2003;2(4 Suppl 1):S23-37.
2003: Adly Yacoub; Clint Mitchell; Jessica Brannon; Elizabeth Rosenberg; Liang Qiao; Robert McKinstry; W Marston Linehan; Zao-shong Su; Devanand Sarkar; Irina Lebedeva; Kristoffer Valerie; Rahul V Gopalkrishnan; Steven Grant; Paul B Fisher; Paul Dent
MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.
Molecular cancer therapeutics 2003;2(7):623-32.
2003: Chunrong Yu; Mohamed Rahmani; Jorge A Almenara; Mark Subler; Geoffrey W Krystal; Daniel Conrad; Lubya Varticovski; Paul Dent; Steven Grant
Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells.
Cancer research 2003;63(9):2118-26.
2003: Liang Qiao; Song Iy Han; Youwen Fang; Jong Sung Park; Seema Gupta; Donna Gilfor; George P Amorino; Kristoffer Valerie; Linda Sealy; John F Engelhardt; Steven Grant; Phillip B Hylemon; Paul Dent
Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes.
Molecular and cellular biology 2003;23(9):3052-66.
2003: Shujie Wang; Zhiliang Wang; Paul Dent; Steven Grant
Induction of tumor necrosis factor by bryostatin 1 is involved in synergistic interactions with paclitaxel in human myeloid leukemia cells.
Blood 2003;101(9):3648-57.
2003: Chunrong Yu; Mohamed Rahmani; Yun Dai; Daniel Conrad; Geoffrey W Krystal; Paul Dent; Steven Grant
The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.
Cancer research 2003;63(8):1822-33.
2003: J Kevin Leach; Liang Qiao; Youwen Fang; Song L Y Han; Donna Gilfor; Paul B Fisher; Steven Grant; Phillip B Hylemon; Darrell Peterson; Paul Dent
Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3.
Journal of gastroenterology and hepatology 2003;18(4):376-85.
2003: Adly Yacoub; Robert McKinstry; Darin Hinman; Theodore Chung; Paul Dent; Michael P Hagan
Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling.
Radiation research 2003;159(4):439-52.
2003: Paul Dent; Adly Yacoub; Joseph N Contessa; Ruben Caron; George P Amorino; Kristoffer Valerie; Michael P Hagan; Steven Grant; Rupert K Schmidt-Ullrich
Stress and radiation-induced activation of multiple intracellular signaling pathways.
Radiation research 2003;159(3):283-300.
2003: Zao-Zhong Su; Irina Lebedeva; Devanand Sarkar; Rahul V Gopalkrishnan; Moira Sauane; Carter Sigmon; Adly Yacoub; Kristoffer Valerie; Paul Dent; Paul B Fisher
Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.
Oncogene 2003;22(8):1164-80.
2003: Moira Sauane; Rahul V Gopalkrishnan; Devanand Sarkar; Zao-Zhong Su; Irina Lebedeva; Paul Dent; Sidney Pestka; Paul B Fisher
MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine.
Cytokine & growth factor reviews 2003;14(1):35-51.
2003: Paul Dent; Liang Qiao; Donna Gilfor; Michael J Birrer; Steven Grant; Paul B Fisher
The regulation of tumor suppressor genes by oncogenes.
Methods in molecular biology (Clifton, N.J.) 2003;222():269-92.
2003: Leanne Cartee; Sonia C Maggio; Rebecca Smith; Heidi Sankala; Paul Dent; Steven Grant
Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol.
Molecular cancer therapeutics 2003;2(1):83-93.
2002: Chunrong Yu; Yun Dai; Paul Dent; Steven Grant
Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571.
Cancer biology & therapy 2002;1(6):674-82.
2002: Steven Grant; Paul Dent
Conversion of drug-induced differentiation to apoptosis by pharmacologic cyclin-dependent kinase inhibitors.
Cell cycle (Georgetown, Tex.) 2002;1(6):383-8.
2002: Yun Dai; Terry Landowski; Steven T Rosen; Paul Dent; Steven Grant
Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism.
Blood 2002;100(9):3333-43.
2002: Devanand Sarkar; Zao-Zhong Su; Irina Lebedeva; Moira Sauane; Rahul V Gopalkrishnan; Paul Dent; Paul B Fisher
mda-7 (IL-24): signaling and functional roles.
BioTechniques 2002;Suppl():30-9.
2002: Paul Dent
Ribonucleotide reductase inhibition: regulation of the radiosensitive phenotype via NF kappa B and Bcl-2.
Cancer biology & therapy 2002;1(5):546-7.
2002: Chunrong Yu; Geoffrey W Krystal; Paul Dent; Steven Grant
Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(9):2976-84.
2002: Leanne Cartee; Heidi Sankala; Christine Davis; Rebecca Smith; Sonia C Maggio; Peck-Sun Lin; Paul Dent; Steven Grant
7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism.
International journal of oncology 2002;21(2):351-9.
2002: Devanand Sarkar; Zao-Zhong Su; Irina Lebedeva; Moira Sauane; Rahul V Gopalkrishnan; Kristoffer Valerie; Paul Dent; Paul B Fisher
mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10054-9.
2002: George P Amorino; Virginia M Hamilton; Kristoffer Valerie; Paul Dent; Guido Lammering; Rupert K Schmidt-Ullrich
Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells.
Molecular biology of the cell 2002;13(7):2233-44.
2002: Zao-Zhong Su; Rahul V Gopalkrishnan; Gopeshwar Narayan; Paul Dent; Paul B Fisher
Progression elevated gene-3, PEG-3, induces genomic instability in rodent and human tumor cells.
Journal of cellular physiology 2002;192(1):34-44.
2002: Liang Qiao; Robert McKinstry; Seema Gupta; Donna Gilfor; Jolene J Windle; Phillip B Hylemon; Steven Grant; Paul B Fisher; Paul Dent
Cyclin kinase inhibitor p21 potentiates bile acid-induced apoptosis in hepatocytes that is dependent on p53.
Hepatology (Baltimore, Md.) 2002;36(1):39-48.
2002: Joseph N Contessa; Jaime Hampton; Guido Lammering; Ross B Mikkelsen; Paul Dent; Kristoffer Valerie; Rupert K Schmidt-Ullrich
Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells.
Oncogene 2002;21(25):4032-41.
2002: Leanne Cartee; Rebecca Smith; Yun Dai; Mohamed Rahmani; Roberto R Rosato; Jorge A Almenara; Paul Dent; Steven Grant
Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways.
Molecular pharmacology 2002;61(6):1313-21.
2002: Robert McKinstry; Liang Qiao; Adly Yacoub; Yun Dai; Roy H Decker; Shawn Holt; Michael P Hagan; Steven Grant; Paul Dent
Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.
Cancer biology & therapy 2002;1(3):243-53.
2002: Liang Qiao; Adly Yacoub; Elaine Studer; Seema Gupta; Xin-Yan Pei; Steven Grant; Phillip B Hylemon; Paul Dent
Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes.
Hepatology (Baltimore, Md.) 2002;35(4):779-89.
2002: Yun Dai; Paul Dent; Steven Grant
Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A.
Cell cycle (Georgetown, Tex.) 2002;1(2):143-52.
2002: Liang Qiao; Adly Yacoub; Robert McKinstry; Jong Sung Park; Ruben Caron; Paul B Fisher; Michael P Hagan; Steven Grant; Paul Dent
Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms.
Cancer biology & therapy 2002;1(2):168-76.
2002: Roy H Decker; Shujie Wang; Yun Dai; Paul Dent; Steven Grant
Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis.
Cancer biology & therapy 2002;1(2):136-44.
2002: Yi-Ping Rao; Elaine Studer; R Todd Stravitz; Seema Gupta; Liang Qiao; Paul Dent; Phillip B Hylemon
Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes.
Hepatology (Baltimore, Md.) 2002;35(2):307-14.
2002: Steven Grant; Liang Qiao; Paul Dent
Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival.
Frontiers in bioscience : a journal and virtual library 2002;7():d376-89.
2002: Steven Grant; Paul B Fisher; Paul Dent
The role of signal transduction pathways in drug and radiation resistance.
Cancer treatment and research 2002;112():89-108.
2002: Chunrong Yu; Geoffrey Krystal; Lyuba Varticovksi; Robert McKinstry; Mohamed Rahmani; Paul Dent; Steven Grant
Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.
Cancer research 2002;62(1):188-99.
2001: Liang Qiao; K Leach; Robert McKinstry; Donna Gilfor; Adly Yacoub; Jong Sung Park; Steven Grant; Phillip B Hylemon; Paul B Fisher; Paul Dent
Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression.
Hepatology (Baltimore, Md.) 2001;34(5):906-17.
2001: Adly Yacoub; J S Park; L Qiao; Paul Dent; Michael P Hagan
MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion.
International journal of radiation biology 2001;77(10):1067-78.
2001: Chunrong Yu; Zhiliang Wang; Paul Dent; Steven Grant
MEK1/2 inhibitors promote Ara-C-induced apoptosis but not loss of Deltapsi(m) in HL-60 cells.
Biochemical and biophysical research communications 2001;286(5):1011-8.
2001: Liang Qiao; Elaine Studer; K Leach; Robert McKinstry; Seema Gupta; Roy H Decker; R Kukreja; Kristoffer Valerie; Prakash S Nagarkatti; Wafik S El-Deiry; J Molkentin; Rupert K Schmidt-Ullrich; Paul B Fisher; Steven Grant; Phillip B Hylemon; Paul Dent
Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.
Molecular biology of the cell 2001;12(9):2629-45.
2001: Zhaozhong Su; Irina Lebedeva; Rahul V Gopalkrishnan; NI Goldstein; Cy A Stein; J C Reed; Paul Dent; Paul B Fisher
A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10332-7.
2001: Yun Dai; C Yu; V Singh; L Tang; Z Wang; R McInistry; Paul Dent; Steven Grant
Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
Cancer research 2001;61(13):5106-15.
2001: Chunrong Yu; Shujie Wang; Paul Dent; Steven Grant
Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway.
Molecular pharmacology 2001;60(1):143-54.
2001: Guido Lammering; Theodore H Hewit; William Hawkins; Joseph N Contessa; DB Reardon; Peck-Sun Lin; Kristoffer Valerie; Paul Dent; Ross B Mikkelsen; Rupert K Schmidt-Ullrich
Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization.
Journal of the National Cancer Institute 2001;93(12):921-9.
2001: Jong Sung Park; Liang Qiao; Zao-Zhong Su; Darin Hinman; Karen A Willoughby; Robert McKinstry; Adly Yacoub; Gregory J Duigou; C S H Young; Steven Grant; Michael P Hagan; E Ellis; Paul B Fisher; Paul Dent
Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways.
Oncogene 2001;20(25):3266-80.
2001: Seema Gupta; R Todd Stravitz; Paul Dent; Phillip B Hylemon
Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway.
The Journal of biological chemistry 2001;276(19):15816-22.
2001: Magdalena Leszczyniecka; T Roberts; Paul Dent; Steven Grant; Paul B Fisher
Differentiation therapy of human cancer: basic science and clinical applications.
Pharmacology & therapeutics 2001;90(2-3):105-56.
2001: Z Su; Y Shi; R Friedman; L Qiao; R McKinstry; Darin Hinman; Paul Dent; Paul B Fisher
PEA3 sites within the progression elevated gene-3 (PEG-3) promoter and mitogen-activated protein kinase contribute to differential PEG-3 expression in Ha-ras and v-raf oncogene transformed rat embryo cells.
Nucleic acids research 2001;29(8):1661-71.
2001: Paul Dent; Steven Grant
Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):775-83.
2001: GD Bowers; D Reardon; T Hewitt; Paul Dent; Ross B Mikkelsen; Kristoffer Valerie; Guido Lammering; Cyrus Amir; Rupert K Schmidt-Ullrich
The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.
Oncogene 2001;20(11):1388-97.
2001: Leanne Cartee; Zhiliang Wang; Roy H Decker; Srikumar Chellappan; Gina Fusaro; K G Hirsch; Heidi Sankala; Paul Dent; Steven Grant
The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells.
Cancer research 2001;61(6):2583-91.
2001: Guido Lammering; Kristoffer Valerie; Peck-Sun Lin; Ross B Mikkelsen; Joseph N Contessa; Jeffrey Feden; Julie Farnsworth; Paul Dent; Rupert K Schmidt-Ullrich
Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3):682-90.
2001: S Harvey; Roy H Decker; Yun Dai; G Schaefer; L Tang; Lora Kramer; Paul Dent; Steven Grant
Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(2):320-30.
2001: Paul Dent; C Logsdon; B Nicke; Kristoffer Valerie; Julie Farnsworth; Rupert K Schmidt-Ullrich; DB Reardon
Recombinant adenoviral expression of dominant-negative Ras N17 blocking radiation-induced activation of mitogen-activated protein kinase pathway.
Methods in enzymology 2001;333():28-37.
2000: L Tang; Lawrence Boise; Paul Dent; Steven Grant
Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01).
Biochemical pharmacology 2000;60(10):1445-56.
2000: MT Madireddi; Paul Dent; Paul B Fisher
AP-1 and C/EBP transcription factors contribute to mda-7 gene promoter activity during human melanoma differentiation.
Journal of cellular physiology 2000;185(1):36-46.
2000: Jong Sung Park; Liang Qiao; Donna Gilfor; M Y Yang; Phillip B Hylemon; C Benz; G Darlington; G Firestone; Paul B Fisher; Paul Dent
A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes.
Molecular biology of the cell 2000;11(9):2915-32.
2000: Zhiliang Wang; Shujie Wang; Paul B Fisher; Paul Dent; Steven Grant
Evidence of a functional role for the cyclin-dependent kinase inhibitor p21CIP1 in leukemic cell (U937) differentiation induced by low concentrations of 1-beta-D-arabinofuranosylcytosine.
Differentiation; research in biological diversity 2000;66(1):1-13.
2000: M Spector; Van Anh Nguyen; X Sheng; L He; John J Woodward; S Fan; Clive M Baumgarten; George Kunos; Paul Dent; Bin Gao
Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells.
Experimental cell research 2000;258(1):109-20.
2000: Michael P Hagan; L Wang; J R Hanley; Jong Sung Park; Paul Dent
Ionizing radiation-induced mitogen-activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2/M-phase arrest.
Radiation research 2000;153(4):371-83.
2000: MT Madireddi; Paul Dent; Paul B Fisher
Regulation of mda-7 gene expression during human melanoma differentiation.
Oncogene 2000;19(10):1362-8.
2000: Rupert K Schmidt-Ullrich; Paul Dent; Steven Grant; Ross B Mikkelsen; Kristoffer Valerie
Signal transduction and cellular radiation responses.
Radiation research 2000;153(3):245-57.
2000: Leanne Cartee; Julie Vrana; Zhiliang Wang; Jong Sung Park; Michael J Birrer; Paul B Fisher; Steven Grant; Paul Dent
Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway.
International journal of oncology 2000;16(2):413-22.
2000: Jong Sung Park; S Boyer; K Mitchell; Donna Gilfor; Michael J Birrer; G Darlington; Wafik S El-Deiry; G L Firestone; K Munger; V Band; Paul B Fisher; Paul Dent
Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1/WAF1/MDA6).
The Journal of biological chemistry 2000;275(1):18-28.
1999: Jong Sung Park; S Carter; DB Reardon; Rupert K Schmidt-Ullrich; Paul Dent; Paul B Fisher
Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells.
Molecular biology of the cell 1999;10(12):4231-46.
1999: Mohiuddin M Taher; T Baumgardner; Paul Dent; Kristoffer Valerie
Genetic evidence that stress-activated p38 MAP kinase is necessary but not sufficient for UV activation of HIV gene expression.
Biochemistry 1999;38(40):13055-62.
1999: Shujie Wang; Zhiliang Wang; Lawrence Boise; Paul Dent; Steven Grant
Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL.
Leukemia 1999;13(10):1564-73.
1999: W David Jarvis; Charlene R Johnson; FA Fornari; Jong Sung Park; Paul Dent; Steven Grant
Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1384-92.
1999: DB Reardon; Joseph N Contessa; Ross B Mikkelsen; Kristoffer Valerie; Cyrus Amir; Paul Dent; Rupert K Schmidt-Ullrich
Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells.
Oncogene 1999;18(33):4756-66.
1999: Paul Dent; DB Reardon; Jong Sung Park; GD Bowers; C Logsdon; Kristoffer Valerie; Rupert K Schmidt-Ullrich
Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death.
Molecular biology of the cell 1999;10(8):2493-506.
1999: Julie Vrana; Lora B Kramer; A M Saunders; X F Zhang; Paul Dent; L F Povirk; Steven Grant
Inhibition of protein kinase C activator-mediated induction of p21CIP1 and p27KIP1 by deoxycytidine analogs in human leukemia cells: relationship to apoptosis and differentiation.
Biochemical pharmacology 1999;58(1):121-31.
1999: Shujie Wang; Zhiliang Wang; Lawrence Boise; Paul Dent; Steven Grant
Loss of the bcl-2 phosphorylation loop domain increases resistance of human leukemia cells (U937) to paclitaxel-mediated mitochondrial dysfunction and apoptosis.
Biochemical and biophysical research communications 1999;259(1):67-72.
1999: Julie Vrana; Steven Grant; Paul Dent
Inhibition of the MAPK pathway abrogates BCL2-mediated survival of leukemia cells after exposure to low-dose ionizing radiation.
Radiation research 1999;151(5):559-69.
1999: Zhiliang Wang; GC Van Tuyle; Daniel Conrad; Paul B Fisher; Paul Dent; Steven Grant
Dysregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis.
Cancer research 1999;59(6):1259-67.
1999: Joseph N Contessa; DB Reardon; D Todd; Paul Dent; Ross B Mikkelsen; Kristoffer Valerie; GD Bowers; Rupert K Schmidt-Ullrich
The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(2):405-11.
1999: Rupert K Schmidt-Ullrich; Joseph N Contessa; Paul Dent; Ross B Mikkelsen; Kristoffer Valerie; DB Reardon; GD Bowers; Peck-Sun Lin
Molecular mechanisms of radiation-induced accelerated repopulation.
Radiation oncology investigations 1999;7(6):321-30.
1998: KL Auer; Jong Sung Park; P Seth; R J Coffey; G Darlington; A Abo; M McMahon; Ronald A DePinho; Paul B Fisher; Paul Dent
Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice.
The Biochemical journal 1998;336 ( Pt 3)():551-60.
1998: Paul Dent; W D Jarvis; Michael J Birrer; Paul B Fisher; R K Schmidt-Ullrich; Steven Grant
The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity.
Leukemia 1998;12(12):1843-50.
1998: W David Jarvis; FA Fornari; Robert M Tombes; R K Erukulla; R Bittman; Gary K Schwartz; Paul Dent; Steven Grant
Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling.
Molecular pharmacology 1998;54(5):844-56.
1998: KL Auer; MS Spector; Robert M Tombes; Prem Seth; Paul B Fisher; Bin Gao; Paul Dent; George Kunos
Alpha-adrenergic inhibition of proliferation in HepG2 cells stably transfected with the alpha1B-adrenergic receptor through a p42MAPkinase/p21Cip1/WAF1-dependent pathway.
FEBS letters 1998;436(1):131-8.
1998: Jing Chen; Edward J N Ishac; Paul Dent; George Kunos; Bin Gao
Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver.
The Biochemical journal 1998;334 ( Pt 3)():669-76.
1998: Shujie Wang; C Y Guo; A Castillo; Paul Dent; Steven Grant
Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937).
Biochemical pharmacology 1998;56(5):635-44.
1998: Brian D Kavanagh; Paul Dent; Rupert K Schmidt-Ullrich; P Chen; Ross B Mikkelsen
Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation.
Radiation research 1998;149(6):579-87.
1998: S Carter; KL Auer; DB Reardon; Michael J Birrer; Paul B Fisher; Kristoffer Valerie; Rupert K Schmidt-Ullrich; Ross B Mikkelsen; Paul Dent
Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells.
Oncogene 1998;16(21):2787-96.
1998: Robert M Tombes; KL Auer; Ross B Mikkelsen; Kristoffer Valerie; M P Wymann; C J Marshall; M McMahon; Paul Dent
The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.
The Biochemical journal 1998;330 ( Pt 3)():1451-60.
1998: KL Auer; Joseph N Contessa; Stefano Brenz-Verca; Luciano Pirola; S Rusconi; G Cooper; A Abo; M P Wymann; R J Davis; Michael J Birrer; Paul Dent
The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.
Molecular biology of the cell 1998;9(3):561-73.
1997: W David Jarvis; FA Fornari; KL Auer; AJ Freemerman; E Szabo; Michael J Birrer; Charlene R Johnson; S E Barbour; Paul Dent; Steven Grant
Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.
Molecular pharmacology 1997;52(6):935-47.
1997: Shujie Wang; Julie Vrana; T M Bartimole; AJ Freemerman; W David Jarvis; Lora B Kramer; Geoffrey W Krystal; Paul Dent; Steven Grant
Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.
Molecular pharmacology 1997;52(6):1000-9.
1997: Rupert K Schmidt-Ullrich; Ross B Mikkelsen; Paul Dent; D G Todd; Kristoffer Valerie; Brian D Kavanagh; Joseph N Contessa; W Kirk Rorrer; P B Chen
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation.
Oncogene 1997;15(10):1191-7.
1997: W David Jarvis; KL Auer; M Spector; George Kunos; Steven Grant; P Hylemon; Ross B Mikkelsen; Paul Dent
Positive and negative regulation of JNK1 by protein kinase C and p42(MAP kinase) in adult rat hepatocytes.
FEBS letters 1997;412(1):9-14.
1997: MS Spector; KL Auer; W D Jarvis; Edward J N Ishac; Bin Gao; George Kunos; Paul Dent
Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes.
Molecular and cellular biology 1997;17(7):3556-65.