Paul Dent

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Publications

TOP 3
Kapitonov Dmitri; Allegood Jeremy C; Mitchell Clint; Hait Nitai C; Almenara Jorge A; Adams Jeffrey K; Zipkin Robert E; Dent Paul; Kordula Tomasz; Milstien Sheldon; Spiegel Sarah
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.
Martin Aditi Pandya; Park Margaret A; Mitchell Clint; Walker Teneille; Rahmani Mohamed; Thorburn Andrew; Häussinger Dieter; Reinehr Roland; Grant Steven; Dent Paul
BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.
Walker Teneille; Mitchell Clint; Park Margaret A; Yacoub Adly; Graf Martin; Rahmani Mohamed; Houghton Peter J; Voelkel-Johnson Christina; Grant Steven; Dent Paul
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.

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All Publications

2009: Kapitonov Dmitri; Allegood Jeremy C; Mitchell Clint; Hait Nitai C; Almenara Jorge A; Adams Jeffrey K; Zipkin Robert E; Dent Paul; Kordula Tomasz; Milstien Sheldon; Spiegel Sarah
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.
Cancer research 2009;69(17):6915-23.
2009: Martin Aditi Pandya; Park Margaret A; Mitchell Clint; Walker Teneille; Rahmani Mohamed; Thorburn Andrew; Häussinger Dieter; Reinehr Roland; Grant Steven; Dent Paul
BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.
Molecular pharmacology 2009;76(2):327-41.
2009: Walker Teneille; Mitchell Clint; Park Margaret A; Yacoub Adly; Graf Martin; Rahmani Mohamed; Houghton Peter J; Voelkel-Johnson Christina; Grant Steven; Dent Paul
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
Molecular pharmacology 2009;76(2):342-55.
2009: Hylemon Phillip B; Zhou Huiping; Pandak William M; Ren Shunlin; Gil Gregorio; Dent Paul
Bile acids as regulatory molecules.
Journal of lipid research 2009;50(8):1509-20.
2009: Chen Li; Jarujaron Sirikalaya; Wu Xudong; Sun Lixin; Zha Weibin; Liang Guang; Wang Xuan; Gurley Emily C; Studer Elaine J; Hylemon Phillip B; Pandak William M; Zhang Luyong; Wang Guangji; Li Xiaokun; Dent Paul; Zhou Huiping
HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages.
Biochemical pharmacology 2009;78(1):70-7.
2009: Graf Martin R; Jia Wentao; Johnson Ross S; Dent Paul; Mitchell Clint; Loria Roger M
Autophagy and the functional roles of Atg5 and beclin-1 in the anti-tumor effects of 3beta androstene 17alpha diol neuro-steroid on malignant glioma cells.
The Journal of steroid biochemistry and molecular biology 2009;115(3-5):137-45.
2009: Dent Paul; Curiel David T; Fisher Paul B; Grant Steven
Synergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2009;12(3):65-73.
2009: Van Maerken Tom; Sarkar Devanand; Speleman Frank; Dent Paul; Weiss William A; Fisher Paul B
Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma.
Journal of cellular physiology 2009;219(3):707-15.
2009: Dasmahapatra Girija; Lembersky Dmitry; Rahmani Mohamed; Kramer Lora; Friedberg Jonathan; Fisher Richard I; Dent Paul; Grant Steven
Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress.
Cancer biology & therapy 2009;8(9):808-19.
2009: Dent Paul; Grant Steven; Fisher Paul B; Curiel David T
PI3K: A rational target for ovarian cancer therapy?
Cancer biology & therapy 2009;8(1):27-30.
2008: Rosato Roberto R; Almenara Jorge A; Maggio Sonia C; Coe Stefanie; Atadja Peter; Dent Paul; Grant Steven
Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions.
Molecular cancer therapeutics 2008;7(10):3285-97.
2008: Park Margaret A; Zhang Guo; Martin Aditi Pandya; Hamed Hossein; Mitchell Clint; Hylemon Philip B; Graf Martin; Rahmani Mohamed; Ryan Kevin; Liu Xiang; Spiegel Sarah; Norris James; Fisher Paul B; Grant Steven; Dent Paul
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.
Cancer biology & therapy 2008;7(10):1648-62.
2008: Park Margaret A; Zhang Guo; Norris James; Hylemon Philip B; Fisher Paul B; Grant Steven; Dent Paul
Regulation of autophagy by ceramide-CD95-PERK signaling.
Autophagy 2008;4(7):929-31.
2008: Park Margaret A; Zhang Guo; Mitchell Clint; Rahmani Mohamed; Hamed Hossein; Hagan Michael P; Yacoub Adly; Curiel David T; Fisher Paul B; Grant Steven; Dent Paul
Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
Molecular cancer therapeutics 2008;7(9):2633-48.
2008: Lebedeva Irina V; Su Zhao-zhong; Vozhilla Nichollaq; Chatman Lejuan; Sarkar Devanand; Dent Paul; Athar Mohammad; Fisher Paul B
Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol.
Cancer research 2008;68(18):7439-47.
2008: Zhang Guo; Park Margaret A; Mitchell Clint; Hamed Hossein; Rahmani Mohamed; Martin Aditi Pandya; Curiel David T; Yacoub Adly; Graf Martin; Lee Ray; Roberts John D; Fisher Paul B; Grant Steven; Dent Paul
Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(17):5385-99.
2008: Dent Paul; Yacoub Adly; Park Margaret; Sarkar Devanand; Shah Khalid; Curiel David T; Grant Steven; Fisher Paul B
Searching for a cure: gene therapy for glioblastoma.
Cancer biology & therapy 2008;7(9):1335-40.
2008: Dai Yun; Chen Shuang; Pei Xin-Yan; Almenara Jorge A; Kramer Lora B; Venditti Charis A; Dent Paul; Grant Steven
Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells.
Blood 2008;112(6):2439-49.
2008: Zhang Guo; Park Margaret A; Mitchell Clint; Walker Teneille; Hamed Hossein; Studer Elaine; Graf Martin; Rahmani Mohamed; Gupta Seema; Hylemon Philip B; Fisher Paul B; Grant Steven; Dent Paul
Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling.
The Journal of biological chemistry 2008;283(36):24343-58.
2008: Martin Aditi Pandya; Miller Anna; Emad Luni; Rahmani Mohammed; Walker Teneille; Mitchell Clint; Hagan Michael P; Park Margaret A; Yacoub Adly; Fisher Paul B; Grant Steven; Dent Paul
Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation.
Molecular pharmacology 2008;74(3):807-22.
2008: Dai Yun; Chen Shuang; Venditti Charis A; Pei Xin-Yan; Nguyen Tri K; Dent Paul; Grant Steven
Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate.
Blood 2008;112(3):793-804.
2008: Oyesanya Regina A; Lee Zendra P; Wu Jinhua; Chen Jing; Song Yuanda; Mukherjee Abir; Dent Paul; Kordula Tomasz; Zhou Huiping; Fang Xianjun
Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(8):2639-51.
2008: Lebedeva Irina V; Su Zhao-Zhong; Vozhilla Nichollaq; Chatman Lejuan; Sarkar Devanand; Dent Paul; Athar Mohammad; Fisher Paul B
Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis.
Molecular cancer therapeutics 2008;7(7):2042-50.
2008: Sauane Moira; Su Zao-Zhong; Gupta Pankaj; Lebedeva Irina V; Dent Paul; Sarkar Devanand; Fisher Paul B
Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9763-8.
2008: Tsuruta Yuko; Pereboeva Larisa; Breidenbach Martina; Rein Daniel T; Wang Minghui; Alvarez Ronald D; Siegal Gene P; Dent Paul; Fisher Paul B; Curiel David T
A fiber-modified mesothelin promoter-based conditionally replicating adenovirus for treatment of ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(11):3582-8.
2008: Yacoub Adly; Hamed Hossein; Emdad Luni; Dos Santos Wagner; Gupta Pankaj; Broaddus William C; Ramakrishnan Viswanathan; Sarkar Devanand; Shah Khalid; Curiel David T; Grant Steven; Fisher Paul B; Dent Paul
MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors.
Cancer biology & therapy 2008;7(6):917-33.
2008: Gupta Pankaj; Emdad Luni; Lebedeva Irina V; Sarkar Devanand; Dent Paul; Curiel David T; Settleman Jeffrey; Fisher Paul B
Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva.
Journal of cellular physiology 2008;215(3):827-36.
2008: Paul C P L; Everts M; Glasgow J N; Dent P; Fisher P B; Ulasov I V; Lesniak M S; Stoff-Khalili M A; Roth J C; Preuss M A; Dirven C M F; Lamfers M L M; Siegal G P; Zhu Z B; Curiel D T
Characterization of infectivity of knob-modified adenoviral vectors in glioma.
Cancer biology & therapy 2008;7(5):786-93.
2008: Sarkar D; Su Z-Z; Park E-S; Vozhilla N; Dent P; Curiel D T; Fisher P B
A cancer terminator virus eradicates both primary and distant human melanomas.
Cancer gene therapy 2008;15(5):293-302.
2008: Park Margaret A; Yacoub Adly; Sarkar Devanand; Emdad Luni; Rahmani Mohammed; Spiegel Sarah; Koumenis Costas; Graf Martin; Curiel David T; Grant Steven; Fisher Paul B; Dent Paul
PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells.
Autophagy 2008;4(4):513-5.
2008: Hamed Hossein; Mitchell Clint; Park Margaret A; Hanna David; Martin Aditi Pandya; Harrison Benjamin; Hawkins William; Curiel David A; Fisher Paul B; Grant Steven; Yacoub Adly; Hagan Michael P; Dent Paul
Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo.
Cancer biology & therapy 2008;7(4):587-93.
2008: Park Margaret A; Curiel David T; Koumenis Costas; Graf Martin; Chen Ching-Shih; Fisher Paul B; Grant Steven; Dent Paul
PERK-dependent regulation of HSP70 expression and the regulation of autophagy.
Autophagy 2008;4(3):364-7.
2008: Park Margaret A; Yacoub Adly; Rahmani Mohammed; Zhang Guo; Hart Lori; Hagan Michael P; Calderwood Stuart K; Sherman Michael Y; Koumenis Costas; Spiegel Sarah; Chen Ching-Shih; Graf Martin; Curiel David T; Fisher Paul B; Grant Steven; Dent Paul
OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells.
Molecular pharmacology 2008;73(4):1168-84.
2008: Hamed Hossein; Hawkins William; Mitchell Clint; Gilfor Donna; Zhang Guo; Pei Xin-Yan; Dai Yun; Hagan Michael P; Roberts John D; Yacoub Adly; Grant Steven; Dent Paul
Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo.
Molecular cancer therapeutics 2008;7(3):616-29.
2008: Yacoub Adly; Gupta Pankaj; Park Margaret A; Rhamani Mohammed; Hamed Hossein; Hanna David; Zhang Guo; Sarkar Devanand; Lebedeva Irina V; Emdad Luni; Koumenis Costas; Curiel David T; Grant Steven; Fisher Paul B; Dent Paul
Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling.
Molecular cancer therapeutics 2008;7(2):314-29.
2008: Yacoub Adly; Park Margaret A; Gupta Pankaj; Rahmani Mohammed; Zhang Guo; Hamed Hossein; Hanna David; Sarkar Devanand; Lebedeva Irina V; Emdad Luni; Sauane Moira; Vozhilla Nicollaq; Spiegel Sarah; Koumenis Costas; Graf Martin; Curiel David T; Grant Steven; Fisher Paul B; Dent Paul
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.
Molecular cancer therapeutics 2008;7(2):297-313.
2008: Sarkar Devanand; Dent Paul; Curiel David T; Fisher Paul B
Acquired and innate resistance to the cancer-specific apoptosis-inducing cytokine, mda-7/IL-24: not insurmountable therapeutic problems.
Cancer biology & therapy 2008;7(1):109-12.
2008: Dai Yun; Chen Shuang; Kramer Lora B; Funk Vanessa L; Dent Paul; Grant Steven
Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):549-58.
2007: Mitchell Clint; Park Maragret A; Zhang Guo; Yacoub Adly; Curiel David T; Fisher Paul B; Roberts John D; Grant Steven; Dent Paul
Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.
Molecular cancer therapeutics 2007;6(12 Pt 1):3101-12.
2007: Emdad Luni; Lebedeva Irina V; Su Zao-Zhong; Sarkar Devanand; Dent Paul; Curiel David T; Fisher Paul B
Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells.
Molecular cancer therapeutics 2007;6(11):2985-94.
2007: Sankala Heidi M; Hait Nitai C; Paugh Steven W; Shida Dai; Lépine Sandrine; Elmore Lynne W; Dent Paul; Milstien Sheldon; Spiegel Sarah
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin.
Cancer research 2007;67(21):10466-74.
2007: Fisher Paul B; Sarkar Devanand; Lebedeva Irina V; Emdad Luni; Gupta Pankaj; Sauane Moira; Su Zao-zhong; Grant Steven; Dent Paul; Curiel David T; Senzer Neil; Nemunaitis John
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma.
Toxicology and applied pharmacology 2007;224(3):300-7.
2007: Rahmani Mohamed; Nguyen Tri K; Dent Paul; Grant Steven
The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation.
Molecular pharmacology 2007;72(3):788-95.
2007: Mitchell Clint; Kabolizadeh Peyman; Ryan John; Roberts John D; Yacoub Adly; Curiel David T; Fisher Paul B; Hagan Michael P; Farrell Nicholas P; Grant Steven; Dent Paul
Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling.
Molecular pharmacology 2007;72(3):704-14.
2007: Pei Xin-Yan; Dai Yun; Tenorio Sarah; Lu Jianghua; Harada Hisashi; Dent Paul; Grant Steven
MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.
Blood 2007;110(6):2092-101.
2007: Rahmani Mohamed; Davis Eric Maynard; Crabtree Timothy Ryan; Habibi Joseph Reza; Nguyen Tri K; Dent Paul; Grant Steven
The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress.
Molecular and cellular biology 2007;27(15):5499-513.
2007: Hagan Michael P; Yacoub Adly; Dent Paul
Radiation-induced PARP activation is enhanced through EGFR-ERK signaling.
Journal of cellular biochemistry 2007;101(6):1384-93.
2007: Dasmahapatra Girija; Yerram Nitin; Dai Yun; Dent Paul; Grant Steven
Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(14):4280-90.
2007: Grant Steven; Dent Paul
Simultaneous interruption of signal transduction and cell cycle regulatory pathways: implications for new approaches to the treatment of childhood leukemias.
Current drug targets 2007;8(6):751-9.
2007: Sarkar Devanand; Lebedeva Irina V; Su Zao-zhong; Park Eun-Sook; Chatman Lejuan; Vozhilla Nicollaq; Dent Paul; Curiel David T; Fisher Paul B
Eradication of therapy-resistant human prostate tumors using a cancer terminator virus.
Cancer research 2007;67(11):5434-42.
2007: Sarkar Devanand; Lebedeva Irina V; Gupta Pankaj; Emdad Luni; Sauane Moira; Dent Paul; Curiel David T; Fisher Paul B
Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?
Expert opinion on biological therapy 2007;7(5):577-86.
2007: Tsuruta Yuko; Pereboeva Larisa; Glasgow Joel N; Rein Daniel T; Kawakami Yosuke; Alvarez Ronald D; Rocconi Rodney P; Siegal Gene P; Dent Paul; Fisher Paul B; Curiel David T
A mosaic fiber adenovirus serotype 5 vector containing reovirus sigma 1 and adenovirus serotype 3 knob fibers increases transduction in an ovarian cancer ex vivo system via a coxsackie and adenovirus receptor-independent pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(9):2777-83.
2007: Dai Yun; Khanna Payal; Chen Shuang; Pei Xin-Yan; Dent Paul; Grant Steven
Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.
Blood 2007;109(10):4415-23.
2007: Nguyen Tri K; Rahmani Mohamed; Harada Hisashi; Dent Paul; Grant Steven
MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825.
Blood 2007;109(9):4006-15.
2007: Fang Youwen; Studer Elaine; Mitchell Clint; Grant Steven; Pandak William M; Hylemon Philip B; Dent Paul
Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.
Molecular pharmacology 2007;71(4):1122-8.
2007: Valerie Kristoffer; Yacoub Adly; Hagan Michael P; Curiel David T; Fisher Paul B; Grant Steven; Dent Paul
Radiation-induced cell signaling: inside-out and outside-in.
Molecular cancer therapeutics 2007;6(3):789-801.
2007: Lebedeva Irina V; Washington Ilyas; Sarkar Devanand; Clark Jennifer A; Fine Robert L; Dent Paul; Curiel David T; Turro Nicholas J; Fisher Paul B
Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3484-9.
2007: Rosato Roberto R; Almenara Jorge A; Kolla Sarah S; Maggio Sonia C; Coe Stefanie; Giménez Maria S; Dent Paul; Grant Steven
Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions.
Molecular cancer therapeutics 2007;6(2):692-702.
2007: Mitchell Clint; Park Margaret A; Zhang Guo; Han Song Iy; Harada Hisashi; Franklin Richard A; Yacoub Adly; Li Pin-Lan; Hylemon Philip B; Grant Steven; Dent Paul
17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines.
Molecular cancer therapeutics 2007;6(2):618-32.
2007: Golding Sarah E; Rosenberg Elizabeth; Neill Steven; Dent Paul; Povirk Lawrence F; Valerie Kristoffer
Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response.
Cancer research 2007;67(3):1046-53.
2007: Chen Shuang; Dai Yun; Harada Hisashi; Dent Paul; Grant Steven
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.
Cancer research 2007;67(2):782-91.
2007: Yacoub Adly; Hawkins William; Hanna David; Young Hong; Park Margaret A; Grant Mark; Roberts John D; Curiel David T; Fisher Paul B; Valerie Kristoffer; Grant Steven; Hagan Michael P; Dent Paul
Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment.
Molecular pharmacology 2007;71(1):259-75.
2007: Dent Paul; Hylemon Philip B; Grant Steven; Fisher Paul B
Approaches for monitoring signal transduction changes in normal and cancer cells.
Methods in molecular biology (Clifton, N.J.) 2007;383():259-76.
2006: Yacoub Adly; Miller Anna; Caron Ruben W; Qiao Liang; Curiel David A; Fisher Paul B; Hagan Michael P; Grant Steven; Dent Paul
Radiotherapy-induced signal transduction.
Endocrine-related cancer 2006;13 Suppl 1():S99-114.
2006: Pei Xin-Yan; Li Weiqun; Dai Yun; Dent Paul; Grant Steven
Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells.
Molecular pharmacology 2006;70(6):1965-73.
2006: Lin L; Su Z; Lebedeva I V; Gupta P; Boukerche H; Rai T; Barber G N; Dent P; Sarkar D; Fisher P B
Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis.
Cell death and differentiation 2006;13(11):1982-93.
2006: Yacoub Adly; Gilfor Donna; Hawkins William; Park Margaret A; Hanna David; Hagan Michael P; Curiel David T; Fisher Paul B; Grant Steven; Dent Paul
MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo.
Cancer biology & therapy 2006;5(10):1332-9.
2006: Dasmahapatra Girija; Nguyen Tri K; Dent Paul; Grant Steven
Adaphostin and bortezomib induce oxidative injury and apoptosis in imatinib mesylate-resistant hematopoietic cells expressing mutant forms of Bcr/Abl.
Leukemia research 2006;30(10):1263-72.
2006: Gupta Pankaj; Su Zao-zhong; Lebedeva Irina V; Sarkar Devanand; Sauane Moira; Emdad Luni; Bachelor Michael A; Grant Steven; Curiel David T; Dent Paul; Fisher Paul B
mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine.
Pharmacology & therapeutics 2006;111(3):596-628.
2006: Gao Ning; Kramer Lora; Rahmani Mohamed; Dent Paul; Grant Steven
The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism.
Molecular pharmacology 2006;70(2):645-55.
2006: Emdad Luni; Sarkar Devanand; Lebedeva Irina V; Su Zao-Zhong; Gupta Pankaj; Mahasreshti Parameshwar J; Dent Paul; Curiel David T; Fisher Paul B
Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer.
Journal of cellular physiology 2006;208(2):298-306.
2006: Yacoub Adly; Park Margaret A; Hanna David; Hong Young; Mitchell Clint; Pandya Aditi P; Harada Hisashi; Powis Garth; Chen Ching-Shih; Koumenis Costas; Grant Steven; Dent Paul
OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells.
Molecular pharmacology 2006;70(2):589-603.
2006: Nguyen Tri K; Rahmani Mohamed; Gao Ning; Kramer Lora; Corbin Amie S; Druker Brian J; Dent Paul; Grant Steven
Synergistic interactions between DMAG and mitogen-activated protein kinase kinase 1/2 inhibitors in Bcr/abl+ leukemia cells sensitive and resistant to imatinib mesylate.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 1):2239-47.
2006: Su Z-Z; Lebedeva I V; Sarkar D; Emdad L; Gupta P; Kitada S; Dent P; Reed J C; Fisher P B
Ionizing radiation enhances therapeutic activity of mda-7/IL-24: overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2.
Oncogene 2006;25(16):2339-48.
2006: Mahasreshti Parameshwar J; Kataram Manjula; Wu Hongju; Yalavarthy Laxmi Priya; Carey Delicia; Fisher Paul B; Chada Sunil; Alvarez Ronald D; Haisma Hidde J; Dent Paul; Curiel David T
Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy.
Gynecologic oncology 2006;100(3):521-32.
2006: Lebedeva Irina V; Sarkar Devanand; Su Zao-Zhong; Gopalkrishnan Rahul V; Athar Mohammad; Randolph Aaron; Valerie Kristoffer; Dent Paul; Fisher Paul B
Molecular target-based therapy of pancreatic cancer.
Cancer research 2006;66(4):2403-13.
2006: Dai Yun; Hamm Tracy E; Dent Paul; Grant Steven
Cyclin D1 overexpression increases the susceptibility of human U266 myeloma cells to CDK inhibitors through a process involving p130-, p107- and E2F-dependent S phase entry.
Cell cycle (Georgetown, Tex.) 2006;5(4):437-46.
2006: Rosato Roberto R; Maggio Sonia C; Almenara Jorge A; Payne Shawn G; Atadja Peter; Spiegel Sarah; Dent Paul; Grant Steven
The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide.
Molecular pharmacology 2006;69(1):216-25.
2006: Dasmahapatra Girija; Rahmani Mohamed; Dent Paul; Grant Steven
The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism.
Blood 2006;107(1):232-40.
2006: Gao Ning; Rahmani Mohamed; Shi Xianglin; Dent Paul; Grant Steven
Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress.
Blood 2006;107(1):241-9.
2005: Dent Paul; Fang Youwen; Gupta Seema; Studer Elaine; Mitchell Clint; Spiegel Sarah; Hylemon Philip B
Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.
Hepatology (Baltimore, Md.) 2005;42(6):1291-9.
2005: Hawkins William; Mitchell Clint; McKinstry Robert; Gilfor Donna; Starkey James; Dai Yun; Dawson Kathy; Ramakrishnan Viswanathan; Roberts John D; Yacoub Adly; Grant Steven; Dent Paul
Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth.
Cancer biology & therapy 2005;4(11):1275-84.
2005: Rosato Roberto R; Almenara Jorge A; Maggio Sonia C; Atadja Peter; Craig Ruth; Vrana Julie; Dent Paul; Grant Steven
Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells.
Molecular cancer therapeutics 2005;4(11):1772-85.
2005: Dent Paul; Han Song Iy; Mitchell Clint; Studer Elaine; Yacoub Adly; Grandis Jennifer; Grant Steven; Krystal Geoffrey W; Hylemon Philip B
Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.
Biochemical pharmacology 2005;70(11):1685-96.
2005: Su Zhaozhong; Emdad Luni; Sauane Moira; Lebedeva Irina V; Sarkar Devanand; Gupta Pankaj; James C David; Randolph Aaron; Valerie Kirstoffer; Walter Mark R; Dent Paul; Fisher Paul B
Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells.
Oncogene 2005;24(51):7552-66.
2005: Rahmani Mohamed; Davis Eric Maynard; Bauer Cheryl; Dent Paul; Grant Steven
Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation.
The Journal of biological chemistry 2005;280(42):35217-27.
2005: Yu C; Dasmahapatra G; Dent P; Grant S
Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(9):1579-89.
2005: Dai Yun; Rahmani Mohamed; Dent Paul; Grant Steven
Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation.
Molecular and cellular biology 2005;25(13):5429-44.
2005: Dent Paul; Yacoub Adly; Grant Steven; Curiel David T; Fisher Paul B
MDA-7/IL-24 regulates proliferation, invasion and tumor cell radiosensitivity: a new cancer therapy?
Journal of cellular biochemistry 2005;95(4):712-9.
2005: Pei Xin-Yan; Dai Yun; Rahmani Mohamed; Li Weiqun; Dent Paul; Grant Steven
The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(12):4589-600.
2005: Dent Paul; Yacoub Adly; Grant Steven
DMC: novel celecoxib derivatives to rap cancer.
Cancer biology & therapy 2005;4(5):583-4.
2005: Gao Ning; Rahmani Mohamed; Dent Paul; Grant Steven
2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process.
Oncogene 2005;24(23):3797-809.
2005: Rahmani Mohamed; Reese Erin; Dai Yun; Bauer Cheryl; Kramer Lora B; Huang Mei; Jove Richard; Dent Paul; Grant Steven
Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change.
Molecular pharmacology 2005;67(4):1166-76.
2005: Rahmani Mohamed; Reese Erin; Dai Yun; Bauer Cheryl; Payne Shawn G; Dent Paul; Spiegel Sarah; Grant Steven
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.
Cancer research 2005;65(6):2422-32.
2005: Hahn Michael; Li Weiqun; Yu Chunrong; Rahmani Mohamed; Dent Paul; Grant Steven
Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
Molecular cancer therapeutics 2005;4(3):457-70.
2005: Su Zao-zhong; Emdad Luni; Sarkar Devanand; Randolph Aaron; Valerie Kristofer; Yacoub Adly; Dent Paul; Fisher Paul B
Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3).
Oncogene 2005;24(13):2247-55.
2005: Carón Rubén W; Yacoub Adly; Mitchell Clint; Zhu Xiaoyu; Hong Young; Sasazuki Takehiko; Shirasawa Senji; Hagan Michael P; Grant Steven; Dent Paul
Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.
Cell cycle (Georgetown, Tex.) 2005;4(3):456-64.
2005: Carón Rubén W; Yacoub Adly; Li Min; Zhu Xiaoyu; Mitchell Clint; Hong Young; Hawkins William; Sasazuki Takehiko; Shirasawa Senji; Kozikowski Alan P; Dennis Philip A; Hagan Michael P; Grant Steven; Dent Paul
Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.
Molecular cancer therapeutics 2005;4(2):257-70.
2005: Carón Rubén W; Yacoub Adly; Zhu Xiaoyu; Mitchell Clint; Han Song Iy; Sasazuki Takehiko; Shirasawa Senji; Hagan Michael P; Grant Steven; Dent Paul
H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.
Molecular cancer therapeutics 2005;4(2):243-55.
2005: Dai Yun; Rahmani Mohamed; Pei Xin-Yan; Khanna Payal; Han Song Iy; Mitchell Clint; Dent Paul; Grant Steven
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
Blood 2005;105(4):1706-16.
2005: Lebedeva Irina V; Sauane Moira; Gopalkrishnan Rahul V; Sarkar Devanand; Su Zhao-Zhong; Gupta Pankaj; Nemunaitis John; Cunningham Casey; Yacoub Adly; Dent Paul; Fisher Paul B
mda-7/IL-24: exploiting cancer's Achilles' heel.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(1):4-18.
2005: Lebedeva Irina V; Su Zao-Zhong; Sarkar Devanand; Gopalkrishnan Rahul V; Waxman Samuel; Yacoub Adly; Dent Paul; Fisher Paul B
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Oncogene 2005;24(4):585-96.
2004: Dent Paul; Grant Steven
Irofulven: resurgence for alkylating therapy in cancer?
Cancer biology & therapy 2004;3(11):1143-4.
2004: Ahmed Wesam; Rahmani Mohamed; Dent Paul; Grant Steven
The cyclin-dependent kinase inhibitor p21(CIP1/WAF1) blocks paclitaxel-induced G2M arrest and attenuates mitochondrial injury and apoptosis in p53-null human leukemia cells.
Cell cycle (Georgetown, Tex.) 2004;3(10):1305-11.
2004: Fang Youwen; Han Song Iy; Mitchell Clint; Gupta Seema; Studer Elaine; Grant Steven; Hylemon Phillip B; Dent Paul
Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes.
Hepatology (Baltimore, Md.) 2004;40(4):961-71.
2004: Sauane Moira; Gopalkrishnan Rahul V; Choo Heng-Tong; Gupta Pankaj; Lebedeva Irina V; Yacoub Adly; Dent Paul; Fisher Paul B
Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein.
Oncogene 2004;23(46):7679-90.
2004: Gao Ning; Dai Yun; Rahmani Mohamed; Dent Paul; Grant Steven
Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol.
Molecular pharmacology 2004;66(4):956-63.
2004: Hagan Michael; Yacoub Adly; Dent Paul
Ionizing radiation causes a dose-dependent release of transforming growth factor alpha in vitro from irradiated xenografts and during palliative treatment of hormone-refractory prostate carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(17):5724-31.
2004: Leath Charles A; Kataram Manjula; Bhagavatula Pradeep; Gopalkrishnan Rahul V; Dent Paul; Fisher Paul B; Pereboev Alexander; Carey Delicia; Lebedeva Irina V; Haisma Hidde J; Alvarez Ronald D; Curiel David T; Mahasreshti Parameshwar J
Infectivity enhanced adenoviral-mediated mda-7/IL-24 gene therapy for ovarian carcinoma.
Gynecologic oncology 2004;94(2):352-62.
2004: Yacoub Adly; Mitchell Clint; Hong Young; Gopalkrishnan Rahul V; Su Zhao-Zhong; Gupta Pankaj; Sauane Moria; Lebedeva Irina V; Curiel David T; Mahasreshti Parameshwar J; Rosenfeld Myrna R; Broaddus William C; James C David; Grant Steven; Fisher Paul B; Dent Paul
MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells.
Cancer biology & therapy 2004;3(8):739-51.
2004: Dai Yun; Rahmani Mohamed; Corey Seth J; Dent Paul; Grant Steven
A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2.
The Journal of biological chemistry 2004;279(33):34227-39.
2004: Grant Steven; Dent Paul
Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: what's in a name?
Molecular cancer therapeutics 2004;3(7):873-5.
2004: Dai Yun; Rahmani Mohamed; Pei Xin-Yan; Dent Paul; Grant Steven
Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms.
Blood 2004;104(2):509-18.
2004: Sauane Moira; Lebedeva Irina V; Su Zao-zhong; Choo Heng-tong; Randolph Aaron; Valerie Kristoffer; Dent Paul; Gopalkrishnan Rahul V; Fisher Paul B
Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways.
Cancer research 2004;64(9):2988-93.
2004: Yu Chunrong; Rahmani Mohamed; Dent Paul; Grant Steven
The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib.
Experimental cell research 2004;295(2):555-66.
2004: Dai Yun; Pei Xin-Yan; Rahmani Mohamed; Conrad Daniel H; Dent Paul; Grant Steven
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells.
Blood 2004;103(7):2761-70.
2004: Grant Steven; Dent Paul
Activation of MAP kinase pathways by TRAIL: don't expect the obvious.
Cancer biology & therapy 2004;3(3):302-4.
2004: Han Song Iy; Studer Elaine; Gupta Seema; Fang Youwen; Qiao Liang; Li Weiqun; Grant Steven; Hylemon Philip B; Dent Paul
Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes.
Hepatology (Baltimore, Md.) 2004;39(2):456-63.
2004: Gupta Seema; Natarajan Ramesh; Payne Shawn G; Studer Elaine J; Spiegel Sarah; Dent Paul; Hylemon Phillip B
Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation.
The Journal of biological chemistry 2004;279(7):5821-8.
2004: Yu Chunrong; Rahmani Mohamed; Almenara Jorge; Sausville Edward A; Dent Paul; Grant Steven
Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process.
Oncogene 2004;23(7):1364-76.
2003: Rahmani Mohamed; Yu Chunrong; Dai Yun; Reese Erin; Ahmed Wesam; Dent Paul; Grant Steven
Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells.
Cancer research 2003;63(23):8420-7.
2003: Lebedeva Irina V; Su Zao-Zhong; Sarkar Devanand; Kitada Shinichi; Dent Paul; Waxman Samuel; Reed John C; Fisher Paul B
Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species.
Cancer research 2003;63(23):8138-44.
2003: Dai Yun; Dent Paul; Grant Steven
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.
Molecular pharmacology 2003;64(6):1402-9.
2003: Yacoub Adly; Han Song Iy; Caron Ruben; Gilfor Donna; Mooberry Susan; Grant Steven; Dent Paul
Sequence dependent exposure of mammary carcinoma cells to Taxotere and the MEK1/2 inhibitor U0126 causes enhanced cell killing in vitro.
Cancer biology & therapy 2003;2(6):670-6.
2003: Lebedeva Irina V; Sarkar Devanand; Su Zao-Zhong; Kitada Shinichi; Dent Paul; Stein C A; Reed John C; Fisher Paul B
Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24.
Oncogene 2003;22(54):8758-73.
2003: Yu Chunrong; Rahmani Mohamed; Conrad Daniel; Subler Mark; Dent Paul; Grant Steven
The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.
Blood 2003;102(10):3765-74.
2003: Yu Chunrong; Subler Mark; Rahmani Mohamed; Reese Erin; Krystal Geoffrey; Conrad Daniel; Dent Paul; Grant Steven
Induction of apoptosis in BCR/ABL+ cells by histone deacetylase inhibitors involves reciprocal effects on the RAF/MEK/ERK and JNK pathways.
Cancer biology & therapy 2003;2(5):544-51.
2003: Rahmani Mohamed; Yu Chunrong; Reese Erin; Ahmed Wesam; Hirsch Karen; Dent Paul; Grant Steven
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition.
Oncogene 2003;22(40):6231-42.
2003: Dent Paul; Yacoub Adly; Fisher Paul B; Hagan Michael P; Grant Steven
MAPK pathways in radiation responses.
Oncogene 2003;22(37):5885-96.
2003: Jia Wentao; Yu Chunrong; Rahmani Mohamed; Krystal Geoffrey; Sausville Edward A; Dent Paul; Grant Steven
Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.
Blood 2003;102(5):1824-32.
2003: Yacoub Adly; Mitchell Clint; Lister Andrea; Lebedeva Irina V; Sarkar Devanand; Su Zao-Zhong; Sigmon Carter; McKinstry Robert; Ramakrishnan Viswanathan; Qiao Liang; Broaddus William C; Gopalkrishnan Rahul V; Grant Steven; Fisher Paul B; Dent Paul
Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(9):3272-81.
2003: Lammering Guido; Hewit Theodore H; Valerie Kristoffer; Contessa Joseph N; Amorino George P; Dent Paul; Schmidt-Ullrich Rupert K
EGFRvIII-mediated radioresistance through a strong cytoprotective response.
Oncogene 2003;22(36):5545-53.
2003: Sauane Moira; Gopalkrishnan Rahul V; Lebedeva Irina; Mei Mei Xin; Sarkar Devanand; Su Zhao-Zhong; Kang Dong-Chul; Dent Paul; Pestka Sidney; Fisher Paul B
Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways.
Journal of cellular physiology 2003;196(2):334-45.
2003: Yacoub Adly; Mitchell Clint; Lebedeva Irina V; Sarkar Devanand; Su Zao-Zhong; McKinstry Robert; Gopalkrishnan Rahul V; Grant Steven; Fisher Paul B; Dent Paul
mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling.
Cancer biology & therapy 2003;2(4):347-53.
2003: Fisher Paul B; Gopalkrishnan Rahul V; Chada Sunil; Ramesh Rajagopal; Grimm Elizabeth A; Rosenfeld Myrna R; Curiel David T; Dent Paul
mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic.
Cancer biology & therapy 2003;2(4 Suppl 1):S23-37.
2003: Yacoub Adly; Mitchell Clint; Brannon Jessica; Rosenberg Elizabeth; Qiao Liang; McKinstry Robert; Linehan W Marston; Su Zao-shong; Sarkar Devanand; Lebedeva Irina V; Valerie Kristoffer; Gopalkrishnan Rahul V; Grant Steven; Fisher Paul B; Dent Paul
MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.
Molecular cancer therapeutics 2003;2(7):623-32.
2003: Yu Chunrong; Rahmani Mohamed; Almenara Jorge; Subler Mark; Krystal Geoffrey; Conrad Daniel; Varticovski Lubya; Dent Paul; Grant Steven
Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells.
Cancer research 2003;63(9):2118-26.
2003: Qiao Liang; Han Song Iy; Fang Youwen; Park Jong Sung; Gupta Seema; Gilfor Donna; Amorino George; Valerie Kristoffer; Sealy Linda; Engelhardt John F; Grant Steven; Hylemon Philip B; Dent Paul
Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes.
Molecular and cellular biology 2003;23(9):3052-66.
2003: Wang Shujie; Wang Zhiliang; Dent Paul; Grant Steven
Induction of tumor necrosis factor by bryostatin 1 is involved in synergistic interactions with paclitaxel in human myeloid leukemia cells.
Blood 2003;101(9):3648-57.
2003: Yu Chunrong; Rahmani Mohamed; Dai Yun; Conrad Daniel; Krystal Geoffrey; Dent Paul; Grant Steven
The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.
Cancer research 2003;63(8):1822-33.
2003: Leach J Kevin; Qiao Liang; Fang Youwen; Han Song L Y; Gilfor Dpnna; Fisher Paul B; Grant Steven; Hylemon Philip B; Peterson Darrell; Dent Paul
Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3.
Journal of gastroenterology and hepatology 2003;18(4):376-85.
2003: Yacoub Adly; McKinstry Robert; Hinman Darin; Chung Theodore; Dent Paul; Hagan Michael P
Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling.
Radiation research 2003;159(4):439-52.
2003: Dent Paul; Yacoub Adly; Contessa Joseph; Caron Ruben; Amorino George; Valerie Kristoffer; Hagan Michael P; Grant Steven; Schmidt-Ullrich Rupert
Stress and radiation-induced activation of multiple intracellular signaling pathways.
Radiation research 2003;159(3):283-300.
2003: Su Zao-Zhong; Lebedeva Irina V; Sarkar Devanand; Gopalkrishnan Rahul V; Sauane Moira; Sigmon Carter; Yacoub Adly; Valerie Kristoffer; Dent Paul; Fisher Paul B
Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.
Oncogene 2003;22(8):1164-80.
2003: Sauane Moira; Gopalkrishnan Rahul V; Sarkar Devanand; Su Zao Zhong; Lebedeva Irina V; Dent Paul; Pestka Sidney; Fisher Paul B
MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine.
Cytokine & growth factor reviews 2003;14(1):35-51.
2003: Cartee Leanne; Maggio Sonia C; Smith Rebecca; Sankala Heidi M; Dent Paul; Grant Steven
Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol.
Molecular cancer therapeutics 2003;2(1):83-93.
2003: Dent Paul; Qiao Liang; Gilfor Donna; Birrer Michael; Grant Steven; Fisher Paul B
The regulation of tumor suppressor genes by oncogenes.
Methods in molecular biology (Clifton, N.J.) 2003;222():269-92.
2002: Yu Chunrong; Dai Yun; Dent Paul; Grant Steven
Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571.
Cancer biology & therapy 2002;1(6):674-82.
2002: Grant Steven; Dent Paul
Conversion of drug-induced differentiation to apoptosis by pharmacologic cyclin-dependent kinase inhibitors.
Cell cycle (Georgetown, Tex.) 2002;1(6):383-8.
2002: Dai Yun; Landowski Terry H; Rosen Steven T; Dent Paul; Grant Steven
Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism.
Blood 2002;100(9):3333-43.
2002: Sarkar Devanand; Su Zao-zhong; Lebedeva Irina V; Sauane Moira; Gopalkrishnan Rahul V; Dent Paul; Fisher Paul B
mda-7 (IL-24): signaling and functional roles.
BioTechniques 2002;Suppl():30-9.
2002: Dent Paul
Ribonucleotide reductase inhibition: regulation of the radiosensitive phenotype via NF kappa B and Bcl-2.
Cancer biology & therapy 2002;1(5):546-7.
2002: Yu Chunrong; Krystal Geoffrey; Dent Paul; Grant Steven
Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(9):2976-84.
2002: Cartee Leanne; Sankala Heidi; Davis Christine; Smith Rebecca; Maggio Sonia; Lin Peck-Sun; Dent Paul; Grant Steven
7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism.
International journal of oncology 2002;21(2):351-9.
2002: Amorino George P; Hamilton Virginia M; Valerie Kristoffer; Dent Paul; Lammering Guido; Schmidt-Ullrich Rupert K
Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells.
Molecular biology of the cell 2002;13(7):2233-44.
2002: Su Zao-Zhong; Gopalkrishnan Rahul V; Narayan Gopeshwar; Dent Paul; Fisher Paul B
Progression elevated gene-3, PEG-3, induces genomic instability in rodent and human tumor cells.
Journal of cellular physiology 2002;192(1):34-44.
2002: Sarkar Devanand; Su Zao-Zhong; Lebedeva Irina V; Sauane Moira; Gopalkrishnan Rahul V; Valerie Kristoffer; Dent Paul; Fisher Paul B
mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10054-9.
2002: Qiao Liang; McKinstry Robert; Gupta Seema; Gilfor Donna; Windle Jolene J; Hylemon Philip B; Grant Steven; Fisher Paul B; Dent Paul
Cyclin kinase inhibitor p21 potentiates bile acid-induced apoptosis in hepatocytes that is dependent on p53.
Hepatology (Baltimore, Md.) 2002;36(1):39-48.
2002: Contessa Joseph N; Hampton Jaime; Lammering Guido; Mikkelsen Ross B; Dent Paul; Valerie Kristoffer; Schmidt-Ullrich Rupert K
Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells.
Oncogene 2002;21(25):4032-41.
2002: Cartee L; Smith R; Dai Y; Rahmani M; Rosato R; Almenara J; Dent P; Grant S
Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways.
Molecular pharmacology 2002;61(6):1313-21.
2002: McKinstry Robert; Qiao Liang; Yacoub Adly; Dai Yun; Decker Roy; Holt Shawn; Hagan Michael P; Grant Steven; Dent Paul
Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.
Cancer biology & therapy 2002;1(3):243-53.
2002: Qiao Liang; Yacoub Adly; Studer Elaine; Gupta Seema; Pei Xin Yan; Grant Steven; Hylemon Philip B; Dent Paul
Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes.
Hepatology (Baltimore, Md.) 2002;35(4):779-89.
2002: Dai Yun; Dent Paul; Grant Steven
Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A.
Cell cycle (Georgetown, Tex.) 2002;1(2):143-52.
2002: Qiao Liang; Yacoub Adly; McKinstry Robert; Park Jong Sung; Caron Ruben; Fisher Paul B; Hagan Michael P; Grant Steven; Dent Paul
Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms.
Cancer biology & therapy 2002;1(2):168-76.
2002: Decker Roy H; Wang Shujie; Dai Yun; Dent Paul; Grant Steven
Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis.
Cancer biology & therapy 2002;1(2):136-44.
2002: Rao Yi-Ping; Studer Elaine J; Stravitz R Todd; Gupta Seema; Qiao Liang; Dent Paul; Hylemon Phillip B
Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes.
Hepatology (Baltimore, Md.) 2002;35(2):307-14.
2002: Grant Steven; Qiao Liang; Dent Paul
Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival.
Frontiers in bioscience : a journal and virtual library 2002;7():d376-89.
2002: Yu Chunrong; Krystal Geoffrey; Varticovksi Lyuba; McKinstry Robert; Rahmani Mohamed; Dent Paul; Grant Steven
Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.
Cancer research 2002;62(1):188-99.
2002: Grant Steven; Fisher Paul B; Dent Paul
The role of signal transduction pathways in drug and radiation resistance.
Cancer treatment and research 2002;112():89-108.
2001: Qiao L; Leach K; McKinstry R; Gilfor D; Yacoub A; Park J S; Grant S; Hylemon P B; Fisher P B; Dent P
Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression.
Hepatology (Baltimore, Md.) 2001;34(5):906-17.
2001: Yacoub A; Park J S; Qiao L; Dent P; Hagan M P
MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion.
International journal of radiation biology 2001;77(10):1067-78.
2001: Qiao L; Studer E; Leach K; McKinstry R; Gupta S; Decker R; Kukreja R; Valerie K; Nagarkatti P; El Deiry W; Molkentin J; Schmidt-Ullrich R; Fisher P B; Grant S; Hylemon P B; Dent P
Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.
Molecular biology of the cell 2001;12(9):2629-45.
2001: Yu C; Wang Z; Dent P; Grant S
MEK1/2 inhibitors promote Ara-C-induced apoptosis but not loss of Deltapsi(m) in HL-60 cells.
Biochemical and biophysical research communications 2001;286(5):1011-8.
2001: Su Z; Lebedeva I V; Gopalkrishnan R V; Goldstein N I; Stein C A; Reed J C; Dent P; Fisher P B
A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10332-7.
2001: Dai Y; Yu C; Singh V; Tang L; Wang Z; McInistry R; Dent P; Grant S
Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
Cancer research 2001;61(13):5106-15.
2001: Yu C; Wang S; Dent P; Grant S
Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway.
Molecular pharmacology 2001;60(1):143-54.
2001: Lammering G; Hewit T H; Hawkins W T; Contessa J N; Reardon D B; Lin P S; Valerie K; Dent P; Mikkelsen R B; Schmidt-Ullrich R K
Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization.
Journal of the National Cancer Institute 2001;93(12):921-9.
2001: Leszczyniecka M; Roberts T; Dent P; Grant S; Fisher P B
Differentiation therapy of human cancer: basic science and clinical applications.
Pharmacology & therapeutics 2001;90(2-3):105-56.
2001: Park J S; Qiao L; Su Z Z; Hinman D; Willoughby K; McKinstry R; Yacoub A; Duigou G J; Young C S; Grant S; Hagan M P; Ellis E; Fisher P B; Dent P
Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways.
Oncogene 2001;20(25):3266-80.
2001: Gupta S; Stravitz R T; Dent P; Hylemon P B
Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway.
The Journal of biological chemistry 2001;276(19):15816-22.
2001: Dent P; Grant S
Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):775-83.
2001: Su Z; Shi Y; Friedman R; Qiao L; McKinstry R; Hinman D; Dent P; Fisher P B
PEA3 sites within the progression elevated gene-3 (PEG-3) promoter and mitogen-activated protein kinase contribute to differential PEG-3 expression in Ha-ras and v-raf oncogene transformed rat embryo cells.
Nucleic acids research 2001;29(8):1661-71.
2001: Bowers G; Reardon D; Hewitt T; Dent P; Mikkelsen R B; Valerie K; Lammering G; Amir C; Schmidt-Ullrich R K
The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.
Oncogene 2001;20(11):1388-97.
2001: Lammering G; Valerie K; Lin P S; Mikkelsen R B; Contessa J N; Feden J P; Farnsworth J; Dent P; Schmidt-Ullrich R K
Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3):682-90.
2001: Cartee L; Wang Z; Decker R H; Chellappan S P; Fusaro G; Hirsch K G; Sankala H M; Dent P; Grant S
The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells.
Cancer research 2001;61(6):2583-91.
2001: Harvey S; Decker R; Dai Y; Schaefer G; Tang L; Kramer L; Dent P; Grant S
Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(2):320-30.
2001: Dent P; Logsdon C; Nicke B; Valerie K; Farnsworth J; Schmidt-Ullrich R; Reardon D B
Recombinant adenoviral expression of dominant-negative Ras N17 blocking radiation-induced activation of mitogen-activated protein kinase pathway.
Methods in enzymology 2001;333():28-37.
2000: Tang L; Boise L H; Dent P; Grant S
Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01).
Biochemical pharmacology 2000;60(10):1445-56.
2000: Madireddi M T; Dent P; Fisher P B
AP-1 and C/EBP transcription factors contribute to mda-7 gene promoter activity during human melanoma differentiation.
Journal of cellular physiology 2000;185(1):36-46.
2000: Park J S; Qiao L; Gilfor D; Yang M Y; Hylemon P B; Benz C; Darlington G; Firestone G; Fisher P B; Dent P
A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes.
Molecular biology of the cell 2000;11(9):2915-32.
2000: Wang Z; Wang S; Fisher P B; Dent P; Grant S
Evidence of a functional role for the cyclin-dependent kinase inhibitor p21CIP1 in leukemic cell (U937) differentiation induced by low concentrations of 1-beta-D-arabinofuranosylcytosine.
Differentiation; research in biological diversity 2000;66(1):1-13.
2000: Spector M; Nguyen V A; Sheng X; He L; Woodward J; Fan S; Baumgarten C M; Kunos G; Dent P; Gao B
Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells.
Experimental cell research 2000;258(1):109-20.
2000: Hagan M; Wang L; Hanley J R; Park J S; Dent P
Ionizing radiation-induced mitogen-activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2/M-phase arrest.
Radiation research 2000;153(4):371-83.
2000: Madireddi M T; Dent P; Fisher P B
Regulation of mda-7 gene expression during human melanoma differentiation.
Oncogene 2000;19(10):1362-8.
2000: Schmidt-Ullrich R K; Dent P; Grant S; Mikkelsen R B; Valerie K
Signal transduction and cellular radiation responses.
Radiation research 2000;153(3):245-57.
2000: Cartee L; Vrana J A; Wang Z; Park J S; Birrer M; Fisher P B; Grant S; Dent P
Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway.
International journal of oncology 2000;16(2):413-22.
2000: Park J S; Boyer S; Mitchell K; Gilfor D; Birrer M; Darlington G; El Deiry W; Firestone G L; Munger K; Band V; Fisher P B; Dent P
Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1/WAF1/MDA6).
The Journal of biological chemistry 2000;275(1):18-28.
1999: Park J S; Carter S; Reardon D B; Schmidt-Ullrich R; Dent P; Fisher P B
Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells.
Molecular biology of the cell 1999;10(12):4231-46.
1999: Taher M M; Baumgardner T; Dent P; Valerie K
Genetic evidence that stress-activated p38 MAP kinase is necessary but not sufficient for UV activation of HIV gene expression.
Biochemistry 1999;38(40):13055-62.
1999: Wang S; Wang Z; Boise L H; Dent P; Grant S
Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(10):1564-73.
1999: Jarvis W D; Johnson C R; Fornari F A; Park J S; Dent P; Grant S
Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1384-92.
1999: Reardon D B; Contessa J N; Mikkelsen R B; Valerie K; Amir C; Dent P; Schmidt-Ullrich R K
Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells.
Oncogene 1999;18(33):4756-66.
1999: Dent P; Reardon D B; Park J S; Bowers G; Logsdon C; Valerie K; Schmidt-Ullrich R
Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death.
Molecular biology of the cell 1999;10(8):2493-506.
1999: Vrana J A; Kramer L B; Saunders A M; Zhang X F; Dent P; Povirk L F; Grant S
Inhibition of protein kinase C activator-mediated induction of p21CIP1 and p27KIP1 by deoxycytidine analogs in human leukemia cells: relationship to apoptosis and differentiation.
Biochemical pharmacology 1999;58(1):121-31.
1999: Wang S; Wang Z; Boise L; Dent P; Grant S
Loss of the bcl-2 phosphorylation loop domain increases resistance of human leukemia cells (U937) to paclitaxel-mediated mitochondrial dysfunction and apoptosis.
Biochemical and biophysical research communications 1999;259(1):67-72.
1999: Vrana J A; Grant S; Dent P
Inhibition of the MAPK pathway abrogates BCL2-mediated survival of leukemia cells after exposure to low-dose ionizing radiation.
Radiation research 1999;151(5):559-69.
1999: Wang Z; Van Tuyle G; Conrad D; Fisher P B; Dent P; Grant S
Dysregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis.
Cancer research 1999;59(6):1259-67.
1999: Contessa J N; Reardon D B; Todd D; Dent P; Mikkelsen R B; Valerie K; Bowers G D; Schmidt-Ullrich R K
The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(2):405-11.
1999: Schmidt-Ullrich R K; Contessa J N; Dent P; Mikkelsen R B; Valerie K; Reardon D B; Bowers G; Lin P S
Molecular mechanisms of radiation-induced accelerated repopulation.
Radiation oncology investigations 1999;7(6):321-30.
1998: Dent P; Jarvis W D; Birrer M J; Fisher P B; Schmidt-Ullrich R K; Grant S
The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(12):1843-50.
1998: Auer K L; Park J S; Seth P; Coffey R J; Darlington G; Abo A; McMahon M; Depinho R A; Fisher P B; Dent P
Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice.
The Biochemical journal 1998;336 ( Pt 3)():551-60.
1998: Jarvis W D; Fornari F A; Tombes R M; Erukulla R K; Bittman R; Schwartz G K; Dent P; Grant S
Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling.
Molecular pharmacology 1998;54(5):844-56.
1998: Wang S; Guo C Y; Castillo A; Dent P; Grant S
Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937).
Biochemical pharmacology 1998;56(5):635-44.
1998: Auer K L; Spector M S; Tombes R M; Seth P; Fisher P B; Gao B; Dent P; Kunos G
Alpha-adrenergic inhibition of proliferation in HepG2 cells stably transfected with the alpha1B-adrenergic receptor through a p42MAPkinase/p21Cip1/WAF1-dependent pathway.
FEBS letters 1998;436(1):131-8.
1998: Chen J; Ishac E J; Dent P; Kunos G; Gao B
Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver.
The Biochemical journal 1998;334 ( Pt 3)():669-76.
1998: Kavanagh B D; Dent P; Schmidt-Ullrich R K; Chen P; Mikkelsen R B
Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation.
Radiation research 1998;149(6):579-87.
1998: Carter S; Auer K L; Reardon D B; Birrer M; Fisher P B; Valerie K; Schmidt-Ullrich R; Mikkelsen R; Dent P
Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells.
Oncogene 1998;16(21):2787-96.
1998: Tombes R M; Auer K L; Mikkelsen R; Valerie K; Wymann M P; Marshall C J; McMahon M; Dent P
The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.
The Biochemical journal 1998;330 ( Pt 3)():1451-60.
1998: Auer K L; Contessa J; Brenz-Verca S; Pirola L; Rusconi S; Cooper G; Abo A; Wymann M P; Davis R J; Birrer M; Dent P
The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.
Molecular biology of the cell 1998;9(3):561-73.
1997: Jarvis W D; Fornari F A; Auer K L; Freemerman A J; Szabo E; Birrer M J; Johnson C R; Barbour S E; Dent P; Grant S
Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.
Molecular pharmacology 1997;52(6):935-47.
1997: Wang S; Vrana J A; Bartimole T M; Freemerman A J; Jarvis W D; Kramer L B; Krystal G; Dent P; Grant S
Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.
Molecular pharmacology 1997;52(6):1000-9.
1997: Schmidt-Ullrich R K; Mikkelsen R B; Dent P; Todd D G; Valerie K; Kavanagh B D; Contessa J N; Rorrer W K; Chen P B
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation.
Oncogene 1997;15(10):1191-7.
1997: Jarvis W D; Auer K L; Spector M; Kunos G; Grant S; Hylemon P; Mikkelsen R; Dent P
Positive and negative regulation of JNK1 by protein kinase C and p42(MAP kinase) in adult rat hepatocytes.
FEBS letters 1997;412(1):9-14.
1997: Spector M S; Auer K L; Jarvis W D; Ishac E J; Gao B; Kunos G; Dent P
Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes.
Molecular and cellular biology 1997;17(7):3556-65.

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