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John Denu

Research Profile

Chemicals & Drugs

Concepts & Ideas

Phenomena

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Alexander S Hebert; Alan J Higbee; David J Pagliarini; Tomas A Prolla; Sushmita Roy; Ebru Selin Selen; Marco Tonelli; Michael S Westphall; Wei Yu; Fariba Assadi-Porter; Derek J Bailey; Allison J Balloon; Melissa D Boersma; Joshua J Carson; John M Denu; Kristin E Dittenhafer-Reed; Joshua J Coon
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
John E Dominy; Jessica Feldman; Steven P Gygi; Mark P Jedrychowski; Michael J Jurczak; Yoonjin Lee; Raul Mostoslavsky; Kerry Pierce; Joao Paulo Camporez; Helen Chim; Clary B Clish; John M Denu; Hai-Bin Ruan; Gerald I Shulman; Xiaoyong Yang; Pere Puigserver
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
Jessica L Feldman; Kristin E Dittenhafer-Reed; John M Denu
Sirtuin catalysis and regulation.

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All Publications

2013: Alexander S Hebert; Alan J Higbee; David J Pagliarini; Tomas A Prolla; Sushmita Roy; Ebru Selin Selen; Marco Tonelli; Michael S Westphall; Wei Yu; Fariba Assadi-Porter; Derek J Bailey; Allison J Balloon; Melissa D Boersma; Joshua J Carson; John M Denu; Kristin E Dittenhafer-Reed; Joshua J Coon
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Molecular cell 2013;49(1):186-99.
2012: John E Dominy; Jessica Feldman; Steven P Gygi; Mark P Jedrychowski; Michael J Jurczak; Yoonjin Lee; Raul Mostoslavsky; Kerry Pierce; Joao Paulo Camporez; Helen Chim; Clary B Clish; John M Denu; Hai-Bin Ruan; Gerald I Shulman; Xiaoyong Yang; Pere Puigserver
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
Molecular cell 2012;48(6):900-13.
2012: Jessica L Feldman; Kristin E Dittenhafer-Reed; John M Denu
Sirtuin catalysis and regulation.
The Journal of biological chemistry 2012;287(51):42419-27.
2012: John M Denu; Joel M Gottesfeld
Minireview series on sirtuins: from biochemistry to health and disease.
The Journal of biological chemistry 2012;287(51):42417-8.
2012: Elise K Wagner; John B Feltenberger; Rod Flemming; Nidhi Nath; John M Denu
Identification and characterization of small molecule inhibitors of a plant homeodomain finger.
Biochemistry 2012;51(41):8293-306.
2012: Samuel S Oliver; Rajini Srinivasan; John P Svaren; Tatiana G Kutateladze; Catherine A Musselman; John M Denu
Multivalent recognition of histone tails by the PHD fingers of CHD5.
Biochemistry 2012;51(33):6534-44.
2012: John M Denu
Fortifying the link between SIRT1, resveratrol, and mitochondrial function.
Cell metabolism 2012;15(5):566-7.
2012: Wei Yu; Kristin E Dittenhafer-Reed; John M Denu
SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.
The Journal of biological chemistry 2012;287(17):14078-86.
2012: William C Hallows; Wei Yu; John M Denu
Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation.
The Journal of biological chemistry 2012;287(6):3850-8.
2012: Catherine A Musselman; Samuel S Oliver; Julita Ramírez; Jennifer K Sims; Paul A Wade; John M Denu; James Hagman; Joel Mackay; Robyn E Mansfield; Tatiana G Kutateladze
Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(3):787-92.
2012: Elise K Wagner; Brittany N Albaugh; John M Denu
High-throughput strategy to identify inhibitors of histone-binding domains.
Methods in enzymology 2012;512():161-85.
2011: Francis C Peterson; Marianna N Rossi; Ivan Ahel; Dawei Chen; John M Denu; Betsy L Lytle; Brian F Volkman
Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties.
The Journal of biological chemistry 2011;286(41):35955-65.
2011: Samuel S Oliver; John M Denu
Disrupting the reader of histone language.
Angewandte Chemie (International ed. in English) 2011;50(26):5801-3.
2011: Atsushi Kasamatsu; Jiro Kato; Lindsay R Comstock; John M Denu; Motoyuki Nakao; Tohru Ono; Brian C Smith; Joel Moss
Hydrolysis of O-acetyl-ADP-ribose isomers by ADP-ribosylhydrolase 3.
The Journal of biological chemistry 2011;286(24):21110-7.
2011: Patricia W Pan; Jessica L Feldman; Mark K Devries; Aiping Dong; Aled M Edwards; John M Denu
Structure and biochemical functions of SIRT6.
The Journal of biological chemistry 2011;286(16):14575-87.
2011: Dawei Chen; Melanie Vollmar; Marianna N Rossi; Claire Phillips; Rolf Kraehenbuehl; Dea Slade; Pawan V Mehrotra; Frank von Delft; Susan K Crosthwaite; Opher Gileadi; John M Denu; Ivan Ahel
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.
The Journal of biological chemistry 2011;286(15):13261-71.
2011: Robyn E Mansfield; Catherine A Musselman; Ann H Y Kwan; Samuel S Oliver; Adam L Garske; Foteini Davrazou; John M Denu; Tatiana G Kutateladze; Joel Mackay
Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9.
The Journal of biological chemistry 2011;286(13):11779-91.
2011: Brian C Smith; Burr Settles; William C Hallows; Mark W Craven; John M Denu
SIRT3 substrate specificity determined by peptide arrays and machine learning.
ACS chemical biology 2011;6(2):146-57.
2011: Kevin M Arnold; Susan Lee; John M Denu
Processing mechanism and substrate selectivity of the core NuA4 histone acetyltransferase complex.
Biochemistry 2011;50(5):727-37.
2011: Samuel S Oliver; John M Denu
Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language".
Chembiochem : a European journal of chemical biology 2011;12(2):299-307.
2011: Brittany N Albaugh; Kevin M Arnold; John M Denu
KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism.
Chembiochem : a European journal of chemical biology 2011;12(2):290-8.
2011: Kristin E Dittenhafer-Reed; Jessica L Feldman; John M Denu
Catalysis and mechanistic insights into sirtuin activation.
Chembiochem : a European journal of chemical biology 2011;12(2):281-9.
2011: William C Hallows; Wei Yu; Brian C Smith; Mark K Devries; Mark K Devires; James J Ellinger; Shinichi Someya; Michael R Shortreed; Tomas A Prolla; John Lute Markley; Lloyd M Smith; Shimin Zhao; Kun-Liang Guan; John M Denu
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction.
Molecular cell 2011;41(2):139-49.
2010: Tadahiro Shimazu; Matthew David Hirschey; Lan Hua; Kristin E Dittenhafer-Reed; Bjoern Schwer; David Lombard; Yu Li; Jakob Bunkenborg; Frederick W Alt; John M Denu; Matthew P Jacobson; Eric Verdin
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
Cell metabolism 2010;12(6):654-61.
2010: Shinichi Someya; Wei Yu; William C Hallows; Jinze Xu; James M Vann; Christiaan Leeuwenburgh; Masaru Tanokura; John M Denu; Tomas A Prolla
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
Cell 2010;143(5):802-12.
2010: Erin M Kolonko; Brittany N Albaugh; Scott E Lindner; Yuanyuan Chen; Kenneth A Satyshur; Kevin M Arnold; Paul D Kaufman; James L Keck; John M Denu
Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(47):20275-80.
2010: Brittany N Albaugh; Erin M Kolonko; John M Denu
Kinetic mechanism of the Rtt109-Vps75 histone acetyltransferase-chaperone complex.
Biochemistry 2010;49(30):6375-85.
2010: Prasanth S Ariyannur; John R Moffett; Chikkathur N Madhavarao; Peethambaran Arun; Nisha Vishnu; David M Jacobowitz; William C Hallows; John M Denu; Aryan M A Namboodiri
Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain.
The Journal of comparative neurology 2010;518(15):2952-77.
2010: Lei Tong; John M Denu
Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose.
Biochimica et biophysica acta 2010;1804(8):1617-25.
2010: Peethambaran Arun; Chikkathur N Madhavarao; John R Moffett; Kristen Hamilton; Neil E Grunberg; Prasanth S Ariyannur; William A Gahl; Yair Anikster; Steven Mog; William C Hallows; John M Denu; Aryan M A Namboodiri
Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease.
Journal of inherited metabolic disease 2010;33(3):195-210.
2010: Adam L Garske; Samuel S Oliver; Elise K Wagner; Catherine A Musselman; Gary LeRoy; Benjamin A Garcia; Tatiana G Kutateladze; John M Denu
Combinatorial profiling of chromatin binding modules reveals multisite discrimination.
Nature chemical biology 2010;6(4):283-90.
2009: Brian C Smith; William C Hallows; John M Denu
A continuous microplate assay for sirtuins and nicotinamide-producing enzymes.
Analytical biochemistry 2009;394(1):101-9.
2009: Catherine A Musselman; Robyn E Mansfield; Adam L Garske; Foteini Davrazou; Ann H Kwan; Samuel S Oliver; Heather O'Leary; John M Denu; Joel Mackay; Tatiana G Kutateladze
Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications.
The Biochemical journal 2009;423(2):179-87.
2009: William C Hallows; Brian C Smith; Susan Lee; John M Denu
Ure(k)a! Sirtuins Regulate Mitochondria.
Cell 2009;137(3):404-6.
2009: Lei Tong; Susan Lee; John M Denu
Hydrolase regulates NAD+ metabolites and modulates cellular redox.
The Journal of biological chemistry 2009;284(17):11256-66.
2009: Brian C Smith; John M Denu
Chemical mechanisms of histone lysine and arginine modifications.
Biochimica et biophysica acta 2009;1789(1):45-57.
2008: Susan Lee; Lei Tong; John M Denu
Quantification of endogenous sirtuin metabolite O-acetyl-ADP-ribose.
Analytical biochemistry 2008;383(2):174-9.
2008: Christopher Berndsen; John M Denu
Catalysis and substrate selection by histone/protein lysine acetyltransferases.
Current opinion in structural biology 2008;18(6):682-9.
2008: Brian C Smith; William C Hallows; John M Denu
Mechanisms and molecular probes of sirtuins.
Chemistry & biology 2008;15(10):1002-13.
2008: Christopher Berndsen; Toshiaki Tsubota; Scott E Lindner; Susan Lee; James M Holton; Paul D Kaufman; James L Keck; John M Denu
Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75.
Nature structural & molecular biology 2008;15(9):948-56.
2008: Adam L Garske; Gheorghe Craciun; John M Denu
A combinatorial H4 tail library for exploring the histone code.
Biochemistry 2008;47(31):8094-102.
2008: William C Hallows; Brittany N Albaugh; John M Denu
Where in the cell is SIRT3?--functional localization of an NAD+-dependent protein deacetylase.
The Biochemical journal 2008;411(2):e11-3.
2008: Terri M Kowieski; Susan Lee; John M Denu
Acetylation-dependent ADP-ribosylation by Trypanosoma brucei Sir2.
The Journal of biological chemistry 2008;283(9):5317-26.
2008: Jill C Milne; John M Denu
The Sirtuin family: therapeutic targets to treat diseases of aging.
Current opinion in chemical biology 2008;12(1):11-7.
2007: Brian C Smith; John M Denu
Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases.
The Journal of biological chemistry 2007;282(51):37256-65.
2007: Brian C Smith; John M Denu
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
Biochemistry 2007;46(50):14478-86.
2007: Lindsay R Comstock; John M Denu
Synthesis and biochemical evaluation of O-acetyl-ADP-ribose and N-acetyl analogs.
Organic & biomolecular chemistry 2007;5(19):3087-91.
2007: Adam L Garske; Brian C Smith; John M Denu
Linking SIRT2 to Parkinson's disease.
ACS chemical biology 2007;2(8):529-32.
2007: Brian C Smith; John M Denu
Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage.
Journal of the American Chemical Society 2007;129(18):5802-3.
2007: John M Denu
Vitamins and aging: pathways to NAD+ synthesis.
Cell 2007;129(3):453-4.
2007: Toshiaki Tsubota; Christopher Berndsen; Judith A Erkmann; Corey L Smith; Lanhao Yang; Michael A Freitas; John M Denu; Paul D Kaufman
Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexes.
Molecular cell 2007;25(5):703-12.
2007: Christopher Berndsen; William Selleck; Steven J McBryant; Jeffrey C Hansen; Song Tan; John M Denu
Nucleosome recognition by the Piccolo NuA4 histone acetyltransferase complex.
Biochemistry 2007;46(8):2091-9.
2007: Christopher Berndsen; Brittany N Albaugh; Song Tan; John M Denu
Catalytic mechanism of a MYST family histone acetyltransferase.
Biochemistry 2007;46(3):623-9.
2006: Robert C Tyler; Eduard Bitto; Christopher Berndsen; Craig A Bingman; Shanteri Singh; Min S Lee; Gary E Wesenberg; John M Denu; George N Phillips; John Lute Markley
Structure of Arabidopsis thaliana At1g77540 protein, a minimal acetyltransferase from the COG2388 family.
Biochemistry 2006;45(48):14325-36.
2006: Brian C Smith; John M Denu
Sirtuins caught in the act.
Structure (London, England : 1993) 2006;14(8):1207-8.
2006: William C Hallows; Susan Lee; John M Denu
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10230-5.
2006: Olivera Grubisha; Louise A Rafty; Christina L Takanishi; Xiaojie Xu; Lei Tong; Anne-Laure Perraud; Andrew M Scharenberg; John M Denu
Metabolite of SIR2 reaction modulates TRPM2 ion channel.
The Journal of biological chemistry 2006;281(20):14057-65.
2006: Brian C Smith; John M Denu
Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine.
Biochemistry 2006;45(1):272-82.
2006: Adam L Garske; John M Denu
SIRT1 top 40 hits: use of one-bead, one-compound acetyl-peptide libraries and quantum dots to probe deacetylase specificity.
Biochemistry 2006;45(1):94-101.
2005: John M Denu
The Sir 2 family of protein deacetylases.
Current opinion in chemical biology 2005;9(5):431-40.
2005: Olivera Grubisha; Brian C Smith; John M Denu
Small molecule regulation of Sir2 protein deacetylases.
The FEBS journal 2005;272(18):4607-16.
2005: John M Denu
Vitamin B3 and sirtuin function.
Trends in biochemical sciences 2005;30(9):479-83.
2005: Christopher Berndsen; John M Denu
Assays for mechanistic investigations of protein/histone acetyltransferases.
Methods (San Diego, Calif.) 2005;36(4):321-31.
2005: Margie T Borra; Brian C Smith; John M Denu
Mechanism of human SIRT1 activation by resveratrol.
The Journal of biological chemistry 2005;280(17):17187-95.
2004: Manning T Schmidt; Brian C Smith; Michael D Jackson; John M Denu
Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation.
The Journal of biological chemistry 2004;279(38):40122-9.
2004: Margie T Borra; Michael R Langer; James T Slama; John M Denu
Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases.
Biochemistry 2004;43(30):9877-87.
2004: Piotr K Grzyska; Youngjoo Kim; Michael D Jackson; Alvan C Hengge; John M Denu
Probing the transition-state structure of dual-specificity protein phosphatases using a physiological substrate mimic.
Biochemistry 2004;43(27):8807-14.
2004: Margie T Borra; John M Denu
Quantitative assays for characterization of the Sir2 family of NAD(+)-dependent deacetylases.
Methods in enzymology 2004;376():171-87.
2003: Youngjoo Kim; Adrian E Rice; John M Denu
Intramolecular dephosphorylation of ERK by MKP3.
Biochemistry 2003;42(51):15197-207.
2003: Michael D Jackson; Manning T Schmidt; Norman J Oppenheimer; John M Denu
Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases.
The Journal of biological chemistry 2003;278(51):50985-98.
2003: Michael D Jackson; Clark C Fjeld; John M Denu
Probing the function of conserved residues in the serine/threonine phosphatase PP2Calpha.
Biochemistry 2003;42(28):8513-21.
2003: Brian J North; Brett L Marshall; Margie T Borra; John M Denu; Eric Verdin
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
Molecular cell 2003;11(2):437-44.
2003: John M Denu
Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases.
Trends in biochemical sciences 2003;28(1):41-8.
2002: Louise A Rafty; Manning T Schmidt; Anne-Laure Perraud; Andrew M Scharenberg; John M Denu
Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases.
The Journal of biological chemistry 2002;277(49):47114-22.
2002: Robert N Dutnall; John M Denu
Methyl magic and HAT tricks.
Nature structural biology 2002;9(12):888-91.
2002: Laurie A Boyer; Michael R Langer; Kimberly A Crowley; Song Tan; John M Denu; Craig L Peterson
Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes.
Molecular cell 2002;10(4):935-42.
2002: Michael R Langer; Christopher J Fry; Craig L Peterson; John M Denu
Modulating acetyl-CoA binding in the GCN5 family of histone acetyltransferases.
The Journal of biological chemistry 2002;277(30):27337-44.
2002: William H Ludlam; Matthew H Taylor; Kirk G Tanner; John M Denu; Richard H Goodman; Sarah M Smolik
The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogaster.
Molecular and cellular biology 2002;22(11):3832-41.
2002: Michael D Jackson; John M Denu
Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases.
The Journal of biological chemistry 2002;277(21):18535-44.
2002: Margie T Borra; Forest J O'Neill; Michael D Jackson; Brett Marshall; Eric Verdin; Kathy R Foltz; John M Denu
Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases.
The Journal of biological chemistry 2002;277(15):12632-41.
2002: Jacob L Todd; Johanna D Rigas; Louise A Rafty; John M Denu
Dual-specificity protein tyrosine phosphatase VHR down-regulates c-Jun N-terminal kinase (JNK).
Oncogene 2002;21(16):2573-83.
2002: Caleb J Bashor; John M Denu; Richard G Brennan; Buddy Ullman
Kinetic mechanism of adenine phosphoribosyltransferase from Leishmania donovani.
Biochemistry 2002;41(12):4020-31.
2002: Maria A Schumacher; Jacob L Todd; Adrian E Rice; Kirk G Tanner; John M Denu
Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase.
Biochemistry 2002;41(9):3009-17.
2002: John M Denu; Kirk G Tanner
Redox regulation of protein tyrosine phosphatases by hydrogen peroxide: detecting sulfenic acid intermediates and examining reversible inactivation.
Methods in enzymology 2002;348():297-305.
2001: Michael R Langer; Kirk G Tanner; John M Denu
Mutational analysis of conserved residues in the GCN5 family of histone acetyltransferases.
The Journal of biological chemistry 2001;276(33):31321-31.
2001: Michael D Jackson; John M Denu
Molecular reactions of protein phosphatases--insights from structure and chemistry.
Chemical reviews 2001;101(8):2313-40.
2001: Maya Kumano; David Carroll; John M Denu; David Carroll
Calcium-mediated inactivation of the MAP kinase pathway in sea urchin eggs at fertilization.
Developmental biology 2001;236(1):244-57.
2001: Johanna D Rigas; Richard H Hoff; Adrian E Rice; Alvan C Hengge; John M Denu
Transition state analysis and requirement of Asp-262 general acid/base catalyst for full activation of dual-specificity phosphatase MKP3 by extracellular regulated kinase.
Biochemistry 2001;40(14):4398-406.
2001: SY Roth; John M Denu; C David Allis
Histone acetyltransferases.
Annual review of biochemistry 2001;70():81-120.
2000: Kirk G Tanner; Joseph W. Landry; R Sternglanz; John M Denu
Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14178-82.
2000: Kirk G Tanner; Michael R Langer; John M Denu
Kinetic mechanism of human histone acetyltransferase P/CAF.
Biochemistry 2000;39(39):11961-9.
2000: Kirk G Tanner; Michael R Langer; Youngchang Kim; John M Denu
Kinetic mechanism of the histone acetyltransferase GCN5 from yeast.
The Journal of biological chemistry 2000;275(29):22048-55.
2000: Peter Cheung; Kirk G Tanner; Wang L Cheung; P Sassone-Corsi; John M Denu; C David Allis
Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation.
Molecular cell 2000;5(6):905-15.
2000: Youngchang Kim; Kirk G Tanner; John M Denu
A continuous, nonradioactive assay for histone acetyltransferases.
Analytical biochemistry 2000;280(2):308-14.
2000: Clark C Fjeld; Adrian E Rice; Youngchang Kim; K R Gee; John M Denu
Mechanistic basis for catalytic activation of mitogen-activated protein kinase phosphatase 3 by extracellular signal-regulated kinase.
The Journal of biological chemistry 2000;275(10):6749-57.
1999: Clark C Fjeld; John M Denu
Kinetic analysis of human serine/threonine protein phosphatase 2Calpha.
The Journal of biological chemistry 1999;274(29):20336-43.
1999: Kirk G Tanner; Raymond C Trievel; Min-Hao Kuo; R M Howard; Shelley L Berger; C David Allis; Ronen Marmorstein; John M Denu
Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator.
The Journal of biological chemistry 1999;274(26):18157-60.
1999: Jacob L Todd; Kirk G Tanner; John M Denu
Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.
The Journal of biological chemistry 1999;274(19):13271-80.
1998: John M Denu; J E Dixon
Protein tyrosine phosphatases: mechanisms of catalysis and regulation.
Current opinion in chemical biology 1998;2(5):633-41.
1998: S D Bell; John M Denu; J E Dixon; A D Ellington
RNA molecules that bind to and inhibit the active site of a tyrosine phosphatase.
The Journal of biological chemistry 1998;273(23):14309-14.
1998: John M Denu; Kirk G Tanner
Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation.
Biochemistry 1998;37(16):5633-42.
1997: D L Lohse; John M Denu; N Santoro; Jack E Dixon
Roles of aspartic acid-181 and serine-222 in intermediate formation and hydrolysis of the mammalian protein-tyrosine-phosphatase PTP1.
Biochemistry 1997;36(15):4568-75.
1996: A M Wiland; John M Denu; R J Mourey; Jack E Dixon
Purification and kinetic characterization of the mitogen-activated protein kinase phosphatase rVH6.
The Journal of biological chemistry 1996;271(52):33486-92.
1996: John M Denu; Jeanne A Stuckey; Mark Saper; Jack E Dixon
Form and function in protein dephosphorylation.
Cell 1996;87(3):361-4.
1996: A C Hengge; John M Denu; J E Dixon
Transition-state structures for the native dual-specific phosphatase VHR and D92N and S131A mutants. Contributions to the driving force for catalysis.
Biochemistry 1996;35(22):7084-92.
1996: J Yuvaniyama; John M Denu; Jack E Dixon; Mark Saper
Crystal structure of the dual specificity protein phosphatase VHR.
Science (New York, N.Y.) 1996;272(5266):1328-31.
1996: John M Denu; D L Lohse; J Vijayalakshmi; Mark Saper; Jack E Dixon
Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2493-8.
1995: Matthew J Wishart; John M Denu; John Williams; Jack E Dixon
A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase.
The Journal of biological chemistry 1995;270(45):26782-5.
1995: D L Lohse; John M Denu; Jack E Dixon
Insights derived from the structures of the Ser/Thr phosphatases calcineurin and protein phosphatase 1.
Structure (London, England : 1993) 1995;3(10):987-90.
1995: Zhong-Yin Zhang; G Zhou; John M Denu; Li Wu; X Tang; O Mondesert; P Russell; Elizabeth R Butch; K L Guan
Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe.
Biochemistry 1995;34(33):10560-8.
1995: John M Denu; Jack E Dixon
A catalytic mechanism for the dual-specific phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):5910-4.
1995: John M Denu; G Zhou; Y Guo; Jack E Dixon
The catalytic role of aspartic acid-92 in a human dual-specific protein-tyrosine-phosphatase.
Biochemistry 1995;34(10):3396-403.
1995: John M Denu; G Zhou; L Wu; R Zhao; J Yuvaniyama; Mark Saper; Jack E Dixon
The purification and characterization of a human dual-specific protein tyrosine phosphatase.
The Journal of biological chemistry 1995;270(8):3796-803.
1994: G Zhou; John M Denu; L Wu; Jack E Dixon
The catalytic role of Cys124 in the dual specificity phosphatase VHR.
The Journal of biological chemistry 1994;269(45):28084-90.
1994: John M Denu; Paul F Fitzpatrick
pH and kinetic isotope effects on the oxidative half-reaction of D-amino-acid oxidase.
The Journal of biological chemistry 1994;269(21):15054-9.
1994: John M Denu; Paul F Fitzpatrick
Intrinsic primary, secondary, and solvent kinetic isotope effects on the reductive half-reaction of D-amino acid oxidase: evidence against a concerted mechanism.
Biochemistry 1994;33(13):4001-7.
1992: John M Denu; Paul F Fitzpatrick
pH and kinetic isotope effects on the reductive half-reaction of D-amino acid oxidase.
Biochemistry 1992;31(35):8207-15.