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Anna DePaoli-Roach

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Anna A DePaoli-Roach; Matthew S Gentry; Catalina M Meyer; Yasmeen Rahimi; Dyann M Segvich; Carolyn A Worby; Peter J Roach
Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity.
Peter J Roach; Anna A DePaoli-Roach; Thomas D Hurley; Vincent S Tagliabracci
Glycogen and its metabolism: some new developments and old themes.
Sulochanadevi Baskaran; Vimbai M Chikwana; Christopher J Contreras; Keri D Davis; Anna A DePaoli-Roach; Peter J Roach; Wayne A Wilson; Thomas D Hurley
Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen.

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2012: Anna A DePaoli-Roach; Matthew S Gentry; Catalina M Meyer; Yasmeen Rahimi; Dyann M Segvich; Carolyn A Worby; Peter J Roach
Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity.
Human molecular genetics 2012;21(7):1604-10.
2012: Peter J Roach; Anna A DePaoli-Roach; Thomas D Hurley; Vincent S Tagliabracci
Glycogen and its metabolism: some new developments and old themes.
The Biochemical journal 2012;441(3):763-87.
2011: Sulochanadevi Baskaran; Vimbai M Chikwana; Christopher J Contreras; Keri D Davis; Anna A DePaoli-Roach; Peter J Roach; Wayne A Wilson; Thomas D Hurley
Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen.
The Journal of biological chemistry 2011;286(39):33999-4006.
2011: Julie Turnbull; Anna A DePaoli-Roach; Xiaochu Zhao; Miguel A Cortez; Nela Pencea; Erica Tiberia; Mark Piliguian; Peter J Roach; Peixiang Wang; Cameron A Ackerley; Berge A Minassian
PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease.
PLoS genetics 2011;7(4):e1002037.
2011: Vincent S Tagliabracci; Christian Heiss; Chandra Karthik; Christopher J Contreras; John Glushka; Mayumi Ishihara; Parastoo Azadi; Thomas D Hurley; Anna A DePaoli-Roach; Peter J Roach
Phosphate incorporation during glycogen synthesis and Lafora disease.
Cell metabolism 2011;13(3):274-82.
2010: Guangmao Cheng; Masaru Takahashi; Anandakumar Shunmugavel; J Grace Wallenborn; Anna A DePaoli-Roach; Ulrich Gergs; Joachim Neumann; Dhandapani Kuppuswamy; Donald R Menick; George Cooper
Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy.
The Journal of biological chemistry 2010;285(49):38125-40.
2010: Sixin Jiang; Brigitte Heller; Vincent S Tagliabracci; Lanmin Zhai; Jose M Irimia; Anna A DePaoli-Roach; Clark D Wells; Alexander Skurat; Peter J Roach
Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism.
The Journal of biological chemistry 2010;285(45):34960-71.
2010: Sulochanadevi Baskaran; Peter J Roach; Anna A DePaoli-Roach; Thomas D Hurley
Structural basis for glucose-6-phosphate activation of glycogen synthase.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(41):17563-8.
2010: Anna A DePaoli-Roach; Vincent S Tagliabracci; Dyann M Segvich; Catalina M Meyer; Jose M Irimia; Peter J Roach
Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin.
The Journal of biological chemistry 2010;285(33):25372-81.
2010: Jose M Irimia; Catalina M Meyer; Caron L Peper; Lanmin Zhai; Cheryl B Bock; Stephen F Previs; Owen P McGuinness; Anna A DePaoli-Roach; Peter J Roach
Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice.
The Journal of biological chemistry 2010;285(17):12851-61.
2009: Frank Eckerdt; GAETAN PASCREAU; Meridee Phistry; Andrea L Lewellyn; Anna A DePaoli-Roach; James L Maller
Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A.
Cell cycle (Georgetown, Tex.) 2009;8(15):2413-9.
2008: Vincent S Tagliabracci; Jean Marie Girard; Dyann Segvich; Catalina Meyer; Julie Turnbull; Xiaochu Zhao; Berge A Minassian; Anna A DePaoli-Roach; Peter J Roach
Abnormal metabolism of glycogen phosphate as a cause for Lafora disease.
The Journal of biological chemistry 2008;283(49):33816-25.
2008: Nicole Brüchert; Nirmala Mavila; Peter Boknik; Hideo A Baba; Larissa Fabritz; Ulrich Gergs; Uwe Kirchhefer; Paulus Kirchhof; Marek Matus; Wilhelm Schmitz; Anna A DePaoli-Roach; Joachim Neumann
Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.
American journal of physiology. Heart and circulatory physiology 2008;295(4):H1539-46.
2008: David B Savage; Lanmin Zhai; Balasubramanian Ravikumar; Cheol Soo Choi; Johanna E Snaar; Amanda C McGuire; Sung-Eun Wou; Gema Medina-Gomez; Sheene Kim; Cheryl B Bock; Dyann M Segvich; Bhavana Solanky; Dinesh Deelchand; Antonio Vidal-Puig; Nicholas J Wareham; Gerald I Shulman; Fredrik Karpe; Roy Taylor; Bartholomew A Pederson; Peter J Roach; Stephen O'Rahilly; Anna A DePaoli-Roach
A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.
PLoS medicine 2008;5(1):e27.
2007: Vincent S Tagliabracci; Julie Turnbull; Wei Wang; Jean-Marie Girard; Xiaochu Zhao; Alexander Skurat; Antonio V Delgado-Escueta; Berge A Minassian; Anna A DePaoli-Roach; Peter J Roach
Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19262-6.
2007: Thomas D Hurley; Jie Yang; Lili Zhang; Kristie D. Goodwin; Qin Zou; Marc Cortese; A Keith Dunker; Anna A DePaoli-Roach
Structural basis for regulation of protein phosphatase 1 by inhibitor-2.
The Journal of biological chemistry 2007;282(39):28874-83.
2007: Wei Wang; Hannes Lohi; Alexander Skurat; Anna A DePaoli-Roach; Berge A Minassian; Peter J Roach
Glycogen metabolism in tissues from a mouse model of Lafora disease.
Archives of biochemistry and biophysics 2007;457(2):264-9.
2006: Wei Wang; Gretchen E Parker; Alexander Skurat; Nina Raben; Anna A DePaoli-Roach; Peter J Roach
Relationship between glycogen accumulation and the laforin dual specificity phosphatase.
Biochemical and biophysical research communications 2006;350(3):588-92.
2006: Nam Ho Jeoung; Pengfei Wu; Mandar A Joshi; Jerzy Jaskiewicz; Cheryl B Bock; Anna A DePaoli-Roach; Robert Harris
Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation.
The Biochemical journal 2006;397(3):417-25.
2005: Bartholomew A Pederson; Jill M Schroeder; Gretchen E Parker; Micah W Smith; Anna A DePaoli-Roach; Peter J Roach
Glucose metabolism in mice lacking muscle glycogen synthase.
Diabetes 2005;54(12):3466-73.
2005: Uwe Kirchhefer; Hideo A Baba; Peter Bokník; Kristine M Breeden; Nirmala Mavila; Nicole Brüchert; Isabel Justus; Marek Matus; Wilhelm Schmitz; Anna A DePaoli-Roach; Joachim Neumann
Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2.
Cardiovascular research 2005;68(1):98-108.
2005: Bartholomew A Pederson; Carlie R Cope; Jose M Irimia; Jill M Schroeder; Beth L Thurberg; Anna A DePaoli-Roach; Peter J Roach
Mice with elevated muscle glycogen stores do not have improved exercise performance.
Biochemical and biophysical research communications 2005;331(2):491-6.
2005: Bartholomew A Pederson; Carlie R Cope; Jill M Schroeder; Micah W Smith; José M Irimia; Beth L Thurberg; Anna A DePaoli-Roach; Peter J Roach
Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exercise.
The Journal of biological chemistry 2005;280(17):17260-5.
2005: Anand Pathak; Federica del Monte; Wen Zhao; Jo-El Schultz; John N Lorenz; Ilona Bodi; Doug Weiser; Harvey Hahn; Andrew N Carr; Faisal M Syed; Nirmala Mavila; Leena Jha; Jiang Qian; Yehia Marreez; Guoli Chen; Dennis W McGraw; E Kevin Heist; J Luis Guerrero; Anna A DePaoli-Roach; Roger J Hajjar; Evangelia G Kranias
Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1.
Circulation research 2005;96(7):756-66.
2004: Bartholomew A Pederson; Hanying Chen; Jill M Schroeder; Weinian Shou; Anna A DePaoli-Roach; Peter J Roach
Abnormal cardiac development in the absence of heart glycogen.
Molecular and cellular biology 2004;24(16):7179-87.
2004: Leigh C Carmody; Patricia A Bauman; Martha A Bass; Nirmala Mavila; Anna A DePaoli-Roach; Roger J Colbran
A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin.
The Journal of biological chemistry 2004;279(21):21714-23.
2004: Julian C Braz; Kimberly Gregory; Anand Pathak; Wen Zhao; Bogachan Sahin; Raisa Klevitsky; Thomas F Kimball; John N Lorenz; Angus Nairn; Stephen B Liggett; Ilona Bodi; Su Wang; Arnold Schwartz; Edward G Lakatta; Anna A DePaoli-Roach; Jeffrey Robbins; Timothy E Hewett; James A Bibb; Margaret V Westfall; Evangelia G Kranias; Jeffery D Molkentin
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Nature medicine 2004;10(3):248-54.
2003: James H Hurley; Shengwen Zhang; Leighan S Bye; Mark S Marshall; Anna A DePaoli-Roach; Kunliang Guan; Aaron P Fox; Lei Yu
Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase.
BMC neuroscience 2003;4():10.
2003: Takayoshi Isoda; Nazareno Paolocci; Kobra Haghighi; Congrong Wang; Yibin Wang; Dimitrios Georgakopoulos; Giuseppe Servillo; Maria Agnese Della Fazia; Evangelia G Kranias; Anna A DePaoli-Roach; Paolo Sassone-Corsi; David A Kass
Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):144-51.
2003: Anna A DePaoli-Roach; Pier Giuseppe Vilardo; Jong-Hwa Kim; Nirmala Mavila; Bhargavi Vemuri; Peter J Roach
Determination of mammalian glycogen synthase phosphatase activity.
Methods in enzymology 2003;366():17-34.
2002: David A Bennin; Aruni S Arachchige Don; Tiffany Brake; Jennifer L McKenzie; Heidi Rosenbaum; Linette Ortiz; Anna A DePaoli-Roach; Mary C Horne
Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest.
The Journal of biological chemistry 2002;277(30):27449-67.
2002: Andrew N Carr; Albrecht G Schmidt; Yoichi Suzuki; Federica del Monte; Yoji Sato; Carita Lanner; Kristine Breeden; Shao-Ling Jing; Patrick B Allen; Paul Greengard; Atsuko Yatani; Brian D Hoit; Ingrid L Grupp; Roger J Hajjar; Anna A DePaoli-Roach; Evangelia G Kranias
Type 1 phosphatase, a negative regulator of cardiac function.
Molecular and cellular biology 2002;22(12):4124-35.
2002: Jong Hwa Kim; Anna A DePaoli-Roach
Epinephrine control of glycogen metabolism in glycogen-associated protein phosphatase PP1G/R(GL) knockout mice.
Journal of biochemistry and molecular biology 2002;35(3):283-90.
2002: Rosa Gasa; Catherine Clark; Ruojing Yang; Anna A DePaoli-Roach; Christopher B Newgard
Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1.
The Journal of biological chemistry 2002;277(2):1524-30.
2001: william aschenbach; Y Suzuki; K Breeden; Clara Prats; Michael F Hirshman; Scott D Dufresne; Kei Sakamoto; Pier Giuseppe Vilardo; M Steele; Jae Ho Kim; S L Jing; Laurie J Goodyear; Anna A DePaoli-Roach
The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise.
The Journal of biological chemistry 2001;276(43):39959-67.
2001: C Lannér; Y Suzuki; C Bi; Haibo Zhang; L D Cooper; Melissa M Bowker-Kinley; Anna A DePaoli-Roach
Gene structure and expression of the targeting subunit, RGL, of the muscle-specific glycogen-associated type 1 protein phosphatase, PP1G.
Archives of biochemistry and biophysics 2001;388(1):135-45.
2001: Y Suzuki; C Lanner; Jae Ho Kim; Pier Giuseppe Vilardo; H Zhang; Jun Yang; L D Cooper; M Steele; A Kennedy; C B Bock; Angus Scrimgeour; John C Lawrence; Anna A DePaoli-Roach
Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL.
Molecular and cellular biology 2001;21(8):2683-94.
2000: Rosa Gasa; P B Jensen; HK Berman; M J Brady; Anna A DePaoli-Roach; Christopher B Newgard
Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, GL, GM/RGl) expressed in hepatocytes.
The Journal of biological chemistry 2000;275(34):26396-403.
2000: Jun Yang; Thomas D Hurley; Anna A DePaoli-Roach
Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif.
The Journal of biological chemistry 2000;275(30):22635-44.
2000: Lanmin Zhai; J Mu; H Zong; Anna A DePaoli-Roach; Peter J Roach
Structure and chromosomal localization of the human glycogenin-2 gene GYG2.
Gene 2000;242(1-2):229-35.
1997: Yaofeng Zhao; George Boguslawski; R S Zitomer; Anna A DePaoli-Roach
Saccharomyces cerevisiae homologs of mammalian B and B' subunits of protein phosphatase 2A direct the enzyme to distinct cellular functions.
The Journal of biological chemistry 1997;272(13):8256-62.