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Ronald DePinho
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Network (preview)
57
Chin, Lynda
27
Bardeesy, Nabeel
17
Castrillon, Diego
17
Sharpless, Norman
14
Brennan, Cameron
14
Horner, James
12
Wong, Kwok-Kin
11
Protopopov, Alexei
11
Chen, Ken
10
Feng, Bin
10
Alt, Frederick
10
Maser, Richard
10
O'Hagan, Rónán
10
Chu, Gerald
10
David, Gregory
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All Publications
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2009: Paik Ji-hye; Ding Zhihu; Narurkar Rujuta; Ramkissoon Shakti; Muller Florian; Kamoun Walid S; Chae Sung-Suk; Zheng Hongwu; Ying Haoqiang; Mahoney Jed; Hiller David; Jiang Shan; Protopopov Alexei; Wong Wing H; Chin Lynda; Ligon Keith L; DePinho Ronald A
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.
Cell stem cell 2009;5(5):540-53.
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2009: Gidekel Friedlander Sharon Y; Chu Gerald C; Snyder Eric L; Girnius Nomeda; Dibelius Gregory; Crowley Denise; Vasile Eliza; DePinho Ronald A; Jacks Tyler
Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras.
Cancer cell 2009;16(5):379-89.
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2009: Cheng Zhiyong; Guo Shaodong; Copps Kyle; Dong Xiaochen; Kollipara Ramya; Rodgers Joseph T; Depinho Ronald A; Puigserver Pere; White Morris F
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
Nature medicine 2009;15(11):1307-11.
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2009: Srinivasan Lakshmi; Sasaki Yoshiteru; Calado Dinis Pedro; Zhang Baochun; Paik Ji Hye; DePinho Ronald A; Kutok Jeffrey L; Kearney John F; Otipoby Kevin L; Rajewsky Klaus
PI3 kinase signals BCR-dependent mature B cell survival.
Cell 2009;139(3):573-86.
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2009: Plum Leona; Lin Hua V; Dutia Roxanne; Tanaka Jun; Aizawa Kumiko S; Matsumoto Michihiro; Kim Andrea J; Cawley Niamh X; Paik Ji-Hye; Loh Y Peng; DePinho Ronald A; Wardlaw Sharon L; Accili Domenico
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.
Nature medicine 2009;15(10):1195-201.
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2009: Tanaka Jun; Qiang Li; Banks Alexander S; Welch Carrie L; Matsumoto Michihiro; Kitamura Tadahiro; Ido-Kitamura Yukari; DePinho Ronald A; Accili Domenico
Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells.
Diabetes 2009;58(10):2344-54.
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2009: Zhou Wen; Cao Qian; Peng Yan; Zhang Qing-Jun; Castrillon Diego H; DePinho Ronald A; Liu Zhi-Ping
FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation.
Gastroenterology 2009;137(4):1403-14.
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2009: Maher Elizabeth A; Mietz Judy; Arteaga Carlos L; DePinho Ronald A; Mohla Suresh
Brain metastasis: opportunities in basic and translational research.
Cancer research 2009;69(15):6015-20.
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2009: Kitamura Tadahiro; Kitamura Yukari Ido; Kobayashi Masaki; Kikuchi Osamu; Sasaki Tsutomu; Depinho Ronald A; Accili Domenico
Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.
Molecular and cellular biology 2009;29(16):4417-30.
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2009: Guan Ji-Song; Haggarty Stephen J; Giacometti Emanuela; Dannenberg Jan-Hermen; Joseph Nadine; Gao Jun; Nieland Thomas J F; Zhou Ying; Wang Xinyu; Mazitschek Ralph; Bradner James E; DePinho Ronald A; Jaenisch Rudolf; Tsai Li-Huei
HDAC2 negatively regulates memory formation and synaptic plasticity.
Nature 2009;459(7243):55-60.
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2009: Dejean Anne S; Beisner Daniel R; Ch'en Irene L; Kerdiles Yann M; Babour Anna; Arden Karen C; Castrillon Diego H; DePinho Ronald A; Hedrick Stephen M
Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells.
Nature immunology 2009;10(5):504-13.
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2009: van Haaften Gijs; Dalgliesh Gillian L; Davies Helen; Chen Lina; Bignell Graham; Greenman Chris; Edkins Sarah; Hardy Claire; O'Meara Sarah; Teague Jon; Butler Adam; Hinton Jonathan; Latimer Calli; Andrews Jenny; Barthorpe Syd; Beare Dave; Buck Gemma; Campbell Peter J; Cole Jennifer; Forbes Simon; Jia Mingming; Jones David; Kok Chai Yin; Leroy Catherine; Lin Meng-Lay; McBride David J; Maddison Mark; Maquire Simon; McLay Kirsten; Menzies Andrew; Mironenko Tatiana; Mulderrig Lee; Mudie Laura; Pleasance Erin; Shepherd Rebecca; Smith Raffaella; Stebbings Lucy; Stephens Philip; Tang Gurpreet; Tarpey Patrick S; Turner Rachel; Turrell Kelly; Varian Jennifer; West Sofie; Widaa Sara; Wray Paul; Collins V Peter; Ichimura Koichi; Law Simon; Wong John; Yuen Siu Tsan; Leung Suet Yi; Tonon Giovanni; DePinho Ronald A; Tai Yu-Tzu; Anderson Kenneth C; Kahnoski Richard J; Massie Aaron; Khoo Sok Kean; Teh Bin Tean; Stratton Michael R; Futreal P Andrew
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.
Nature genetics 2009;41(5):521-3.
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2009: Dankort David; Curley David P; Cartlidge Robert A; Nelson Betsy; Karnezis Anthony N; Damsky William E; You Mingjian J; DePinho Ronald A; McMahon Martin; Bosenberg Marcus
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.
Nature genetics 2009;41(5):544-52.
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2009: Wu Min; Jung Lina; Cooper Adrian B; Fleet Christina; Chen Lihao; Breault Lyne; Clark Kimberly; Cai Zuhua; Vincent Sylvie; Bottega Steve; Shen Qiong; Richardson Andrea; Bosenburg Marcus; Naber Stephen P; DePinho Ronald A; Kuperwasser Charlotte; Robinson Murray O
Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7022-7.
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2009: Gan Boyi; DePinho Ronald A
mTORC1 signaling governs hematopoietic stem cell quiescence.
Cell cycle (Georgetown, Tex.) 2009;8(7):1003-6.
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2009: Kerdiles Yann M; Beisner Daniel R; Tinoco Roberto; Dejean Anne S; Castrillon Diego H; DePinho Ronald A; Hedrick Stephen M
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.
Nature immunology 2009;10(2):176-84.
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2009: Menon Rajasree; Zhang Qing; Zhang Yan; Fermin Damian; Bardeesy Nabeel; DePinho Ronald A; Lu Chunxia; Hanash Samir M; Omenn Gilbert S; States David J
Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer.
Cancer research 2009;69(1):300-9.
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2009: Polter Abigail; Yang Sufen; Zmijewska Anna A; van Groen Thomas; Paik Ji-Hye; Depinho Ronald A; Peng Stanford L; Jope Richard S; Li Xiaohua
Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.
Biological psychiatry 2009;65(2):150-9.
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2008: Gan Boyi; Sahin Ergün; Jiang Shan; Sanchez-Aguilera Abel; Scott Kenneth L; Chin Lynda; Williams David A; Kwiatkowski David J; DePinho Ronald A
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19384-9.
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2008: Kimmelman Alec C; Hezel Aram F; Aguirre Andrew J; Zheng Hongwu; Paik Ji-Hye; Ying Haoqiang; Chu Gerald C; Zhang Jean X; Sahin Ergun; Yeo Giminna; Ponugoti Aditya; Nabioullin Roustem; Deroo Scott; Yang Shenghong; Wang Xiaoxu; McGrath John P; Protopopova Marina; Ivanova Elena; Zhang Jianhua; Feng Bin; Tsao Ming S; Redston Mark; Protopopov Alexei; Xiao Yonghong; Futreal P Andrew; Hahn William C; Klimstra David S; Chin Lynda; DePinho Ronald A
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19372-7.
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2008: Dengler Hart S; Baracho Gisele V; Omori Sidne A; Bruckner Shane; Arden Karen C; Castrillon Diego H; DePinho Ronald A; Rickert Robert C
Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.
Nature immunology 2008;9(12):1388-98.
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2008: Senokuchi Takafumi; Liang Chien-Ping; Seimon Tracie A; Han Seongah; Matsumoto Michihiro; Banks Alexander S; Paik Ji-Hye; DePinho Ronald A; Accili Domenico; Tabas Ira; Tall Alan R
Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress.
Diabetes 2008;57(11):2967-76.
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2008: Zheng Hongwu; Ying Haoqiang; Yan Haiyan; Kimmelman Alec C; Hiller David J; Chen An-Jou; Perry Samuel R; Tonon Giovanni; Chu Gerald C; Ding Zhihu; Stommel Jayne M; Dunn Katherine L; Wiedemeyer Ruprecht; You Mingjian J; Brennan Cameron; Wang Y Alan; Ligon Keith L; Wong Wing H; Chin Lynda; DePinho Ronald A
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.
Nature 2008;455(7216):1129-33.
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2008: Hu Ping; Geles Kenneth G; Paik Ji-Hye; DePinho Ronald A; Tjian Robert
Codependent activators direct myoblast-specific MyoD transcription.
Developmental cell 2008;15(4):534-46.
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2008: Stegh Alexander H; Chin Lynda; Louis David N; DePinho Ronald A
What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator.
Cell cycle (Georgetown, Tex.) 2008;7(18):2833-9.
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2008: Jeon Hye-Min; Jin Xun; Lee Joong-Seob; Oh Se-Yeong; Sohn Young-Woo; Park Hyo-Jung; Joo Kyeung Min; Park Woong-Yang; Nam Do-Hyun; DePinho Ronald A; Chin Lynda; Kim Hyunggee
Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling.
Genes & development 2008;22(15):2028-33.
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2008: Stegh Alexander H; Kesari Santosh; Mahoney John E; Jenq Harry T; Forloney Kristin L; Protopopov Alexei; Louis David N; Chin Lynda; DePinho Ronald A
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10703-8.
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2008: Dong Xiaocheng C; Copps Kyle D; Guo Shaodong; Li Yedan; Kollipara Ramya; DePinho Ronald A; White Morris F
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.
Cell metabolism 2008;8(1):65-76.
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2008: Aghi M; Visted T; Depinho R A; Chiocca E A
Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16.
Oncogene 2008;27(30):4249-54.
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2008: Faca Vitor M; Song Kenneth S; Wang Hong; Zhang Qing; Krasnoselsky Alexei L; Newcomb Lisa F; Plentz Ruben R; Gurumurthy Sushma; Redston Mark S; Pitteri Sharon J; Pereira-Faca Sandra R; Ireton Renee C; Katayama Hiroyuki; Glukhova Veronika; Phanstiel Douglas; Brenner Dean E; Anderson Michelle A; Misek David; Scholler Nathalie; Urban Nicole D; Barnett Matt J; Edelstein Cim; Goodman Gary E; Thornquist Mark D; McIntosh Martin W; DePinho Ronald A; Bardeesy Nabeel; Hanash Samir M
A mouse to human search for plasma proteome changes associated with pancreatic tumor development.
PLoS medicine 2008;5(6):e123.
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2008: Herzog Sebastian; Hug Eva; Meixlsperger Sonja; Paik Ji-Hye; DePinho Ronald A; Reth Michael; Jumaa Hassan
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway.
Nature immunology 2008;9(6):623-31.
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2008: Kelly Kimberly A; Bardeesy Nabeel; Anbazhagan Rajesh; Gurumurthy Sushma; Berger Justin; Alencar Herlen; Depinho Ronald A; Mahmood Umar; Weissleder Ralph
Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma.
PLoS medicine 2008;5(4):e85.
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2008: Katajisto Pekka; Vaahtomeri Kari; Ekman Niklas; Ventelä Eeva; Ristimäki Ari; Bardeesy Nabeel; Feil Robert; DePinho Ronald A; Mäkelä Tomi P
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.
Nature genetics 2008;40(4):455-9.
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2008: Perera Samanthi A; Maser Richard S; Xia Huili; McNamara Kate; Protopopov Alexei; Chen Liang; Hezel Aram F; Kim Carla F; Bronson Roderick T; Castrillon Diego H; Chin Lynda; Bardeesy Nabeel; Depinho Ronald A; Wong Kwok-Kin
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.
Carcinogenesis 2008;29(4):747-53.
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2008: Hezel Aram F; Gurumurthy Sushma; Granot Zvi; Swisa Avital; Chu Gerry C; Bailey Gerald; Dor Yuval; Bardeesy Nabeel; Depinho Ronald A
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
Molecular and cellular biology 2008;28(7):2414-25.
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2008: David Gregory; Grandinetti Kathryn B; Finnerty Patricia M; Simpson Natalie; Chu Gerald C; Depinho Ronald A
Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4168-72.
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2008: de la Iglesia Núria; Konopka Genevieve; Puram Sidharth V; Chan Jennifer A; Bachoo Robert M; You Mingjian J; Levy David E; Depinho Ronald A; Bonni Azad
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway.
Genes & development 2008;22(4):449-62.
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2008: Zheng H; Ying H; Yan H; Kimmelman A C; Hiller D J; Chen A-J; Perry S R; Tonon G; Chu G C; Ding Z; Stommel J M; Dunn K L; Wiedemeyer R; You M J; Brennan C; Wang Y A; Ligon K L; Wong W H; Chin L; dePinho R A
Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.
Cold Spring Harbor symposia on quantitative biology 2008;73():427-37.
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2008: Zhang Qing; Menon Rajasree; Deutsch Eric W; Pitteri Sharon J; Faca Vitor M; Wang Hong; Newcomb Lisa F; Depinho Ronald A; Bardeesy Nabeel; Dinulescu Daniela; Hung Kenneth E; Kucherlapati Raju; Jacks Tyler; Politi Katerina; Aebersold Ruedi; Omenn Gilbert S; States David J; Hanash Samir M
A mouse plasma peptide atlas as a resource for disease proteomics.
Genome biology 2008;9(6):R93.
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2007: O'Neil Jennifer; Tchinda Joelle; Gutierrez Alejandro; Moreau Lisa; Maser Richard S; Wong Kwok-Kin; Li Wei; McKenna Keith; Liu X Shirley; Feng Bin; Neuberg Donna; Silverman Lewis; DeAngelo Daniel J; Kutok Jeffery L; Rothstein Rodney; DePinho Ronald A; Chin Lynda; Lee Charles; Look A Thomas
Alu elements mediate MYB gene tandem duplication in human T-ALL.
The Journal of experimental medicine 2007;204(13):3059-66.
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2007: Kim Tae-Kyung; Lee Joong-Seob; Oh Se-Yeong; Jin Xun; Choi Yun-Jaie; Lee Tae-Hoon; Lee Eun ho; Choi Young-Ki; You Seungkwon; Chung Yong Gu; Lee Jang-Bo; DePinho Ronald A; Chin Lynda; Kim Hyunggee
Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells.
Cancer research 2007;67(23):11133-40.
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2007: Martin Eric S; Tonon Giovanni; Sinha Raktim; Xiao Yonghong; Feng Bin; Kimmelman Alec C; Protopopov Alexei; Ivanova Elena; Brennan Cameron; Montgomery Kate; Kucherlapati Raju; Bailey Gerald; Redston Mark; Chin Lynda; DePinho Ronald A
Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.
Cancer research 2007;67(22):10736-43.
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2007: Furnari Frank B; Fenton Tim; Bachoo Robert M; Mukasa Akitake; Stommel Jayne M; Stegh Alexander; Hahn William C; Ligon Keith L; Louis David N; Brennan Cameron; Chin Lynda; DePinho Ronald A; Cavenee Webster K
Malignant astrocytic glioma: genetics, biology, and paths to treatment.
Genes & development 2007;21(21):2683-710.
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2007: Stommel Jayne M; Kimmelman Alec C; Ying Haoqiang; Nabioullin Roustem; Ponugoti Aditya H; Wiedemeyer Ruprecht; Stegh Alexander H; Bradner James E; Ligon Keith L; Brennan Cameron; Chin Lynda; DePinho Ronald A
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.
Science (New York, N.Y.) 2007;318(5848):287-90.
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2007: Matsumoto Michihiro; Pocai Alessandro; Rossetti Luciano; Depinho Ronald A; Accili Domenico
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.
Cell metabolism 2007;6(3):208-16.
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2007: Kitamura Tadahiro; Kitamura Yukari Ido; Funahashi Yasuhiro; Shawber Carrie J; Castrillon Diego H; Kollipara Ramya; DePinho Ronald A; Kitajewski Jan; Accili Domenico
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.
The Journal of clinical investigation 2007;117(9):2477-85.
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2007: Sharpless Norman E; DePinho Ronald A
How stem cells age and why this makes us grow old.
Nature reviews. Molecular cell biology 2007;8(9):703-13.
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2007: Chu Gerald C; Kimmelman Alec C; Hezel Aram F; DePinho Ronald A
Stromal biology of pancreatic cancer.
Journal of cellular biochemistry 2007;101(4):887-907.
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2007: Ha Linan; Ichikawa Takeshi; Anver Miriam; Dickins Ross; Lowe Scott; Sharpless Norman E; Krimpenfort Paul; Depinho Ronald A; Bennett Dorothy C; Sviderskaya Elena V; Merlino Glenn
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10968-73.
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2007: Maser Richard S; Choudhury Bhudipa; Campbell Peter J; Feng Bin; Wong Kwok-Kin; Protopopov Alexei; O'Neil Jennifer; Gutierrez Alejandro; Ivanova Elena; Perna Ilana; Lin Eric; Mani Vidya; Jiang Shan; McNamara Kate; Zaghlul Sara; Edkins Sarah; Stevens Claire; Brennan Cameron; Martin Eric S; Wiedemeyer Ruprecht; Kabbarah Omar; Nogueira Cristina; Histen Gavin; Aster Jon; Mansour Marc; Duke Veronique; Foroni Letizia; Fielding Adele K; Goldstone Anthony H; Rowe Jacob M; Wang Yaoqi A; Look A Thomas; Stratton Michael R; Chin Lynda; Futreal P Andrew; DePinho Ronald A
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
Nature 2007;447(7147):966-71.
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2007: Wong K-K; Maser R S; Sahin E; Bailey S T; Xia H; Ji H; McNamara K; Naylor M; Bronson R T; Ghosh S; Welsh R; DePinho R A
Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.
Oncogene 2007;26(20):2815-21.
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2007: Carrasco Daniel R; Sukhdeo Kumar; Protopopova Marina; Sinha Raktim; Enos Miriam; Carrasco Daniel E; Zheng Mei; Mani Mala; Henderson Joel; Pinkus Geraldine S; Munshi Nikhil; Horner James; Ivanova Elena V; Protopopov Alexei; Anderson Kenneth C; Tonon Giovanni; DePinho Ronald A
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis.
Cancer cell 2007;11(4):349-60.
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2007: Yang Dan; McCrann Donald J; Nguyen Hao; St Hilaire Cynthia; DePinho Ronald A; Jones Matthew R; Ravid Katya
Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence.
Aging cell 2007;6(2):257-60.
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2007: Li Hao; Liang Jianping; Castrillon Diego H; DePinho Ronald A; Olson Eric N; Liu Zhi-Ping
FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription.
Molecular and cellular biology 2007;27(7):2676-86.
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2007: Khoo Christine M; Carrasco Daniel R; Bosenberg Marcus W; Paik Ji-Hye; Depinho Ronald A
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3931-6.
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2007: Maser Richard S; Wong Kwok-Kin; Sahin Erguen; Xia Huili; Naylor Maria; Hedberg H Mason; Artandi Steven E; DePinho Ronald A
DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.
Molecular and cellular biology 2007;27(6):2253-65.
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2007: Podar Klaus; Raab Marc S; Tonon Giovanni; Sattler Martin; Barilà Daniela; Zhang Jing; Tai Yu-Tzu; Yasui Hiroshi; Raje Noopur; DePinho Ronald A; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma.
Cancer research 2007;67(4):1680-8.
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2007: Ligon Keith L; Huillard Emmanuelle; Mehta Shwetal; Kesari Santosh; Liu Hongye; Alberta John A; Bachoo Robert M; Kane Michael; Louis David N; Depinho Ronald A; Anderson David J; Stiles Charles D; Rowitch David H
Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.
Neuron 2007;53(4):503-17.
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2007: Sharpless Norman E; DePinho Ronald A
Cancer biology: gone but not forgotten.
Nature 2007;445(7128):606-7.
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2007: Tothova Zuzana; Kollipara Ramya; Huntly Brian J; Lee Benjamin H; Castrillon Diego H; Cullen Dana E; McDowell Elizabeth P; Lazo-Kallanian Suzan; Williams Ifor R; Sears Christopher; Armstrong Scott A; Passegué Emmanuelle; DePinho Ronald A; Gilliland D Gary
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Cell 2007;128(2):325-39.
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2007: Paik Ji-Hye; Kollipara Ramya; Chu Gerald; Ji Hongkai; Xiao Yonghong; Ding Zhihu; Miao Lili; Tothova Zuzana; Horner James W; Carrasco Daniel R; Jiang Shan; Gilliland D Gary; Chin Lynda; Wong Wing H; Castrillon Diego H; DePinho Ronald A
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Cell 2007;128(2):309-23.
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2007: Stegh Alexander H; Kim Hyunggee; Bachoo Robert M; Forloney Kristin L; Zhang Jean; Schulze Harald; Park Kevin; Hannon Gregory J; Yuan Junying; Louis David N; DePinho Ronald A; Chin Lynda
Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma.
Genes & development 2007;21(1):98-111.
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2006: Maher Elizabeth A; Brennan Cameron; Wen Patrick Y; Durso Laura; Ligon Keith L; Richardson Aaron; Khatry Deepak; Feng Bin; Sinha Raktim; Louis David N; Quackenbush John; Black Peter McL; Chin Lynda; DePinho Ronald A
Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.
Cancer research 2006;66(23):11502-13.
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2006: Bardeesy Nabeel; Cheng Kuang-Hung; Berger Justin H; Chu Gerald C; Pahler Jessica; Olson Peter; Hezel Aram F; Horner James; Lauwers Gregory Y; Hanahan Douglas; DePinho Ronald A
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.
Genes & development 2006;20(22):3130-46.
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2006: Liu Fenghua; Park Peter J; Lai Weil; Maher Elizabeth; Chakravarti Arnab; Durso Laura; Jiang Xiuli; Yu Yi; Brosius Amanda; Thomas Meredith; Chin Lynda; Brennan Cameron; DePinho Ronald A; Kohane Isaac; Carroll Rona S; Black Peter M; Johnson Mark D
A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma.
Cancer research 2006;66(22):10815-23.
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2006: David G; Dannenberg J-H; Simpson N; Finnerty P M; Miao L; Turner G M; Ding Z; Carrasco R; Depinho R A
Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53.
Oncogene 2006;25(56):7354-60.
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2006: Farazi Paraskevi A; DePinho Ronald A
The genetic and environmental basis of hepatocellular carcinoma.
Discovery medicine 2006;6(35):182-6.
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2006: Janzen Viktor; Forkert Randolf; Fleming Heather E; Saito Yoriko; Waring Michael T; Dombkowski David M; Cheng Tao; DePinho Ronald A; Sharpless Norman E; Scadden David T
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.
Nature 2006;443(7110):421-6.
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2006: Farazi Paraskevi A; DePinho Ronald A
Hepatocellular carcinoma pathogenesis: from genes to environment.
Nature reviews. Cancer 2006;6(9):674-87.
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2006: Sharpless Norman E; Depinho Ronald A
The mighty mouse: genetically engineered mouse models in cancer drug development.
Nature reviews. Drug discovery 2006;5(9):741-54.
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2006: Okumura Koichi; Mendoza Michelle; Bachoo Robert M; DePinho Ronald A; Cavenee Webster K; Furnari Frank B
PCAF modulates PTEN activity.
The Journal of biological chemistry 2006;281(36):26562-8.
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2006: Farazi Paraskevi A; Zeisberg Michael; Glickman Jonathan; Zhang Yan; Kalluri Raghu; DePinho Ronald A
Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice.
Cancer research 2006;66(13):6622-7.
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2006: Dickie R; Bachoo R M; Rupnick M A; Dallabrida S M; Deloid G M; Lai J; Depinho R A; Rogers R A
Three-dimensional visualization of microvessel architecture of whole-mount tissue by confocal microscopy.
Microvascular research 2006;72(1-2):20-6.
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2006: Hezel Aram F; Kimmelman Alec C; Stanger Ben Z; Bardeesy Nabeel; Depinho Ronald A
Genetics and biology of pancreatic ductal adenocarcinoma.
Genes & development 2006;20(10):1218-49.
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2006: Carrasco Daniel R; Fenton Tim; Sukhdeo Kumar; Protopopova Marina; Enos Miriam; You Mingjian J; Di Vizio Dolores; Nogueira Cristina; Stommel Jayne; Pinkus Geraldine S; Fletcher Christopher; Hornick Jason L; Cavenee Webster K; Furnari Frank B; Depinho Ronald A
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans.
Cancer cell 2006;9(5):379-90.
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2006: Bosenberg Marcus; Muthusamy Viswanathan; Curley David P; Wang Zhenxiong; Hobbs Cara; Nelson Betsy; Nogueira Cristina; Horner James W; Depinho Ronald; Chin Lynda
Characterization of melanocyte-specific inducible Cre recombinase transgenic mice.
Genesis (New York, N.Y. : 2000) 2006;44(5):262-7.
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2006: Farazi Paraskevi A; Glickman Jonathan; Horner James; Depinho Ronald A
Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression.
Cancer research 2006;66(9):4766-73.
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2006: Heltweg Birgit; Gatbonton Tonibelle; Schuler Aaron D; Posakony Jeff; Li Hongzhe; Goehle Sondra; Kollipara Ramya; Depinho Ronald A; Gu Yansong; Simon Julian A; Bedalov Antonio
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.
Cancer research 2006;66(8):4368-77.
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2006: Carrasco Daniel R; Tonon Giovanni; Huang Yongsheng; Zhang Yunyu; Sinha Raktim; Feng Bin; Stewart James P; Zhan Fenghuang; Khatry Deepak; Protopopova Marina; Protopopov Alexei; Sukhdeo Kumar; Hanamura Ichiro; Stephens Owen; Barlogie Bart; Anderson Kenneth C; Chin Lynda; Shaughnessy John D; Brennan Cameron; Depinho Ronald A
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients.
Cancer cell 2006;9(4):313-25.
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2006: Bardeesy Nabeel; Aguirre Andrew J; Chu Gerald C; Cheng Kuang-Hung; Lopez Lyle V; Hezel Aram F; Feng Bin; Brennan Cameron; Weissleder Ralph; Mahmood Umar; Hanahan Douglas; Redston Mark S; Chin Lynda; Depinho Ronald A
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5947-52.
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2006: Haines Brian B; Ryu Chun Jeih; Chang Sandy; Protopopov Alexei; Luch Andreas; Kang Yun Hee; Draganov Dobrin D; Fragoso Maria F; Paik Sang Gi; Hong Hyo Jeong; DePinho Ronald A; Chen Jianzhu
Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations.
Cancer cell 2006;9(2):109-20.
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2006: Safran Michal; Kim William Y; O'Connell Fionnuala; Flippin Lee; Günzler Volkmar; Horner James W; Depinho Ronald A; Kaelin William G
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(1):105-10.
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2005: Shaw Reuben J; Lamia Katja A; Vasquez Debbie; Koo Seung-Hoi; Bardeesy Nabeel; Depinho Ronald A; Montminy Marc; Cantley Lewis C
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Science (New York, N.Y.) 2005;310(5754):1642-6.
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2005: Laud Purnima R; Multani Asha S; Bailey Susan M; Wu Ling; Ma Jin; Kingsley Charles; Lebel Michel; Pathak Sen; DePinho Ronald A; Chang Sandy
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.
Genes & development 2005;19(21):2560-70.
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2005: Luo Ji; McMullen Julie R; Sobkiw Cassandra L; Zhang Li; Dorfman Adam L; Sherwood Megan C; Logsdon M Nicole; Horner James W; DePinho Ronald A; Izumo Seigo; Cantley Lewis C
Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.
Molecular and cellular biology 2005;25(21):9491-502.
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2005: Stanger Ben Z; Stiles Bangyan; Lauwers Gregory Y; Bardeesy Nabeel; Mendoza Michael; Wang Ying; Greenwood Amy; Cheng Kuang-hung; McLaughlin Margaret; Brown Dennis; Depinho Ronald A; Wu Hong; Melton Douglas A; Dor Yuval
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.
Cancer cell 2005;8(3):185-95.
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2005: Potente Michael; Urbich Carmen; Sasaki Ken-ichiro; Hofmann Wolf K; Heeschen Christopher; Aicher Alexandra; Kollipara Ramya; DePinho Ronald A; Zeiher Andreas M; Dimmeler Stefanie
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.
The Journal of clinical investigation 2005;115(9):2382-92.
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2005: Sharpless Norman E; DePinho Ronald A
Cancer: crime and punishment.
Nature 2005;436(7051):636-7.
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2005: Luo Ji; Sobkiw Cassandra L; Logsdon Nicole M; Watt John M; Signoretti Sabina; O'Connell Fionnuala; Shin Eyoung; Shim Youngju; Pao Lily; Neel Benjamin G; Depinho Ronald A; Loda Massimo; Cantley Lewis C
Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10238-43.
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2005: Dannenberg Jan-Hermen; David Gregory; Zhong Sheng; van der Torre Jaco; Wong Wing H; Depinho Ronald A
mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival.
Genes & development 2005;19(13):1581-95.
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2005: Tonon Giovanni; Wong Kwok-Kin; Maulik Gautam; Brennan Cameron; Feng Bin; Zhang Yunyu; Khatry Deepak B; Protopopov Alexei; You Mingjian James; Aguirre Andrew J; Martin Eric S; Yang Zhaohui; Ji Hongbin; Chin Lynda; Depinho Ronald A
High-resolution genomic profiles of human lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9625-30.
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2005: Westbrook Thomas F; Martin Eric S; Schlabach Michael R; Leng Yumei; Liang Anthony C; Feng Bin; Zhao Jean J; Roberts Thomas M; Mandel Gail; Hannon Gregory J; Depinho Ronald A; Chin Lynda; Elledge Stephen J
A genetic screen for candidate tumor suppressors identifies REST.
Cell 2005;121(6):837-48.
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2005: Asher Damon R; Cerny Anna M; Weiler Sarah R; Horner James W; Keeler Marilyn L; Neptune Mychell A; Jones Stephen N; Bronson Roderick T; Depinho Ronald A; Finberg Robert W
Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development.
Genesis (New York, N.Y. : 2000) 2005;42(2):77-85.
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2005: Rünger Thomas M; Vergilis Irene; Sarkar Papri; DePinho Ronald A; Sharpless Norman E
How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer.
Cell cycle (Georgetown, Tex.) 2005;4(5):643-5.
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2005: Okumura Koichi; Zhao Mujun; DePinho Ronald A; Furnari Frank B; Cavenee Webster K
PTEN: a novel anti-oncogenic function independent of phosphatase activity.
Cell cycle (Georgetown, Tex.) 2005;4(4):540-2.
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2005: Okumura Koichi; Zhao Mujun; Depinho Ronald A; Furnari Frank B; Cavenee Webster K
Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2703-6.
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2005: Tonon G; Brennan C; Protopopov A; Maulik G; Feng B; Zhang Y; Khatry D B; You M J; Aguirre A J; Martin E S; Yang Z; Ji H; Chin L; Wong K-K; Depinho R A
Common and contrasting genomic profiles among the major human lung cancer subtypes.
Cold Spring Harbor symposia on quantitative biology 2005;70():11-24.
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2004: Sarkar-Agrawal Papri; Vergilis Irene; Sharpless Norman E; DePinho Ronald A; Rünger Thomas M
Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF.
Journal of the National Cancer Institute 2004;96(23):1790-3.
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2004: Li Zhen; David Gregory; Hung Kwok-Wang; DePinho Ronald A; Fu Amy K Y; Ip Nancy Y
Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription.
The Journal of biological chemistry 2004;279(52):54438-44.
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2004: Keller Charles; Arenkiel Benjamin R; Coffin Cheryl M; El-Bardeesy Nabeel; DePinho Ronald A; Capecchi Mario R
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.
Genes & development 2004;18(21):2614-26.
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2004: Argilla David; Chin Koei; Singh Mallika; Hodgson J Graeme; Bosenberg Marcus; de Solórzano Carlos Ortiz; Lockett Stephen; DePinho Ronald A; Gray Joe; Hanahan Douglas
Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes.
Cancer cell 2004;6(4):373-85.
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2004: Du Xiaobing; Shen Johnny; Kugan Nishan; Furth Emma E; Lombard David B; Cheung Catherine; Pak Sally; Luo Guangbin; Pignolo Robert J; DePinho Ronald A; Guarente Leonard; Johnson F Brad
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.
Molecular and cellular biology 2004;24(19):8437-46.
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2004: DePinho Ronald A; Polyak Kornelia
Cancer chromosomes in crisis.
Nature genetics 2004;36(9):932-4.
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2004: Maser Richard S; DePinho Ronald A
Telomeres and the DNA damage response: why the fox is guarding the henhouse.
DNA repair 2004;3(8-9):979-88.
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2004: Chang Sandy; Multani Asha S; Cabrera Noelia G; Naylor Maria L; Laud Purnima; Lombard David; Pathak Sen; Guarente Leonard; DePinho Ronald A
Essential role of limiting telomeres in the pathogenesis of Werner syndrome.
Nature genetics 2004;36(8):877-82.
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2004: Shaw Reuben J; Bardeesy Nabeel; Manning Brendan D; Lopez Lyle; Kosmatka Monica; DePinho Ronald A; Cantley Lewis C
The LKB1 tumor suppressor negatively regulates mTOR signaling.
Cancer cell 2004;6(1):91-9.
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2004: Corradetti Michael N; Inoki Ken; Bardeesy Nabeel; DePinho Ronald A; Guan Kun-Liang
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.
Genes & development 2004;18(13):1533-8.
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2004: Aguirre Andrew J; Brennan Cameron; Bailey Gerald; Sinha Raktim; Feng Bin; Leo Christopher; Zhang Yunyu; Zhang Jean; Gans Joseph D; Bardeesy Nabeel; Cauwels Craig; Cordon-Cardo Carlos; Redston Mark S; DePinho Ronald A; Chin Lynda
High-resolution characterization of the pancreatic adenocarcinoma genome.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):9067-72.
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2004: Bachoo Robert M; Kim Ryung S; Ligon Keith L; Maher Elizabeth A; Brennan Cameron; Billings Nathan; Chan Suzanne; Li Cheng; Rowitch David H; Wong Wing H; DePinho Ronald A
Molecular diversity of astrocytes with implications for neurological disorders.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(22):8384-9.
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2004: Tuveson David A; Shaw Alice T; Willis Nicholas A; Silver Daniel P; Jackson Erica L; Chang Sandy; Mercer Kim L; Grochow Rebecca; Hock Hanno; Crowley Denise; Hingorani Sunil R; Zaks Tal; King Catrina; Jacobetz Michael A; Wang Lifu; Bronson Roderick T; Orkin Stuart H; DePinho Ronald A; Jacks Tyler
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.
Cancer cell 2004;5(4):375-87.
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2004: Sachs Zohar; Sharpless Norman E; DePinho Ronald A; Rosenberg Naomi
p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis.
Journal of virology 2004;78(7):3304-11.
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2004: Shaw Reuben J; Kosmatka Monica; Bardeesy Nabeel; Hurley Rebecca L; Witters Lee A; DePinho Ronald A; Cantley Lewis C
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3329-35.
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2004: Sharpless Norman E; Ramsey Matthew R; Balasubramanian Periasamy; Castrillon Diego H; DePinho Ronald A
The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.
Oncogene 2004;23(2):379-85.
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2004: Sharpless Norman E; DePinho Ronald A
Telomeres, stem cells, senescence, and cancer.
The Journal of clinical investigation 2004;113(2):160-8.
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2004: Attardi Laura D; DePinho Ronald A
Conquering the complexity of p53.
Nature genetics 2004;36(1):7-8.
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2003: Aguirre Andrew J; Bardeesy Nabeel; Sinha Manisha; Lopez Lyle; Tuveson David A; Horner James; Redston Mark S; DePinho Ronald A
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.
Genes & development 2003;17(24):3112-26.
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2003: Hallows Janice L; Chen Ken; DePinho Ronald A; Vincent Inez
Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(33):10633-44.
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2003: Safran Michal; Kim William Y; Kung Andrew L; Horner James W; DePinho Ron A; Kaelin William G
Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination.
Molecular imaging : official journal of the Society for Molecular Imaging 2003;2(4):297-302.
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2003: David Gregory; Turner Garth M; Yao Yao; Protopopov Alexei; DePinho Ronald A
mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells.
Genes & development 2003;17(19):2396-405.
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2003: Ossipova Olga; Bardeesy Nabeel; DePinho Ronald A; Green Jeremy B A
LKB1 (XEEK1) regulates Wnt signalling in vertebrate development.
Nature cell biology 2003;5(10):889-94.
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2003: Farazi Paraskevi A; Glickman Jonathan; Jiang Shan; Yu Alice; Rudolph Karl Lenhard; DePinho Ronald A
Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma.
Cancer research 2003;63(16):5021-7.
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2003: Wong Kwok-Kin; DePinho Ronald A
Walking the telomere plank into cancer.
Journal of the National Cancer Institute 2003;95(16):1184-6.
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2003: Castrillon Diego H; Miao Lili; Kollipara Ramya; Horner James W; DePinho Ronald A
Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a.
Science (New York, N.Y.) 2003;301(5630):215-8.
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2003: Allsopp Richard C; Morin Gregg B; DePinho Ronald; Harley Calvin B; Weissman Irving L
Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation.
Blood 2003;102(2):517-20.
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2003: D'Amico Mark; Wu Kongming; Di Vizio Dolores; Reutens Anne T; Stahl Mark; Fu Maofu; Albanese Chris; Russell Robert G; Muller William J; White Michael; Negassa Abdissa; Lee Han-Woong; DePinho Ronald A; Pestell Richard G
The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.
Cancer research 2003;63(12):3395-402.
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2003: DePinho Ronald A; Wong Kwok-Kin
The age of cancer: telomeres, checkpoints, and longevity.
The Journal of clinical investigation 2003;111(7):S9-14.
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2003: Weiss William A; Burns Michael J; Hackett Christopher; Aldape Ken; Hill John R; Kuriyama Hiroko; Kuriyama Nagato; Milshteyn Nadezhda; Roberts Tim; Wendland Michael F; DePinho Ron; Israel Mark A
Genetic determinants of malignancy in a mouse model for oligodendroglioma.
Cancer research 2003;63(7):1589-95.
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2003: Allsopp Richard C; Morin Gregg B; Horner James W; DePinho Ronald; Harley Calvin B; Weissman Irving L
Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells.
Nature medicine 2003;9(4):369-71.
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2003: Gibson Steven L; Dai Charlotte Y; Lee Han-Woong; DePinho Ronald A; Gee Michael S; Lee William M F; Furth Emma E; Brensinger Colleen; Enders Greg H
Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus.
Cancer research 2003;63(4):742-6.
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2003: Wong Kwok-Kin; Maser Richard S; Bachoo Robert M; Menon Jayant; Carrasco Daniel R; Gu Yansong; Alt Frederick W; DePinho Ronald A
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
Nature 2003;421(6923):643-8.
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2003: Maser Richard S; DePinho Ronald A
Take care of your chromosomes lest cancer take care of you.
Cancer cell 2003;3(1):4-6.
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2003: Chang Sandy; Khoo Christine M; Naylor Maria L; Maser Richard S; DePinho Ronald A
Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression.
Genes & development 2003;17(1):88-100.
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2002: Bardeesy Nabeel; DePinho Ronald A
Pancreatic cancer biology and genetics.
Nature reviews. Cancer 2002;2(12):897-909.
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2002: Recio Juan A; Noonan Frances P; Takayama Hisashi; Anver Miriam R; Duray Paul; Rush Walter L; Lindner Gerd; De Fabo Edward C; DePinho Ronald A; Merlino Glenn
Ink4a/arf deficiency promotes ultraviolet radiation-induced melanomagenesis.
Cancer research 2002;62(22):6724-30.
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2002: Sharp Richard; Recio Juan A; Jhappan Chamelli; Otsuka Toshiyuki; Liu Shiquan; Yu Yanlin; Liu Wenjing; Anver Miriam; Navid Fariba; Helman Lee J; DePinho Ronald A; Merlino Glenn
Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis.
Nature medicine 2002;8(11):1276-80.
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2002: Chang Sandy; DePinho Ronald A
Telomerase extracurricular activities.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12520-2.
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2002: Bardeesy Nabeel; Sinha Manisha; Hezel Aram F; Signoretti Sabina; Hathaway Nathaniel A; Sharpless Norman E; Loda Massimo; Carrasco Daniel R; DePinho Ronald A
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.
Nature 2002;419(6903):162-7.
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2002: Maser Richard S; DePinho Ronald A
Keeping telomerase in its place.
Nature medicine 2002;8(9):934-6.
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2002: Lund Anders H; Turner Geoffrey; Trubetskoy Alla; Verhoeven Els; Wientjens Ellen; Hulsman Danielle; Russell Robert; DePinho Ronald A; Lenz Jack; van Lohuizen Maarten
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice.
Nature genetics 2002;32(1):160-5.
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2002: O'Hagan Rónán C; Chang Sandy; Maser Richard S; Mohan Ramya; Artandi Steven E; Chin Lynda; DePinho Ronald A
Telomere dysfunction provokes regional amplification and deletion in cancer genomes.
Cancer cell 2002;2(2):149-55.
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2002: Zhang Zhongqiu; Wang Yian; Herzog Christopher R; Liu Gongjie; Lee Han-Woong; DePinho Ronald A; You Ming
A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression.
Oncogene 2002;21(38):5960-6.
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2002: Sharpless Norman E; DePinho Ronald A
p53: good cop/bad cop.
Cell 2002;110(1):9-12.
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2002: Lee Chien-kuo; Raz Regina; Gimeno Ramon; Gertner Rachel; Wistinghausen Birte; Takeshita Kenichi; DePinho Ronald A; Levy David E
STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation.
Immunity 2002;17(1):63-72.
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2002: Maser Richard S; DePinho Ronald A
Connecting chromosomes, crisis, and cancer.
Science (New York, N.Y.) 2002;297(5581):565-9.
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2002: Artandi Steven E; Alson Scott; Tietze Maja K; Sharpless Norman E; Ye Siqin; Greenberg Roger A; Castrillon Diego H; Horner James W; Weiler Sarah R; Carrasco Ruben D; DePinho Ronald A
Constitutive telomerase expression promotes mammary carcinomas in aging mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8191-6.
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2002: David Gregory; Neptune Mychell A; DePinho Ronald A
SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities.
The Journal of biological chemistry 2002;277(26):23658-63.
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2002: Sharpless Norman E; Alson Scott; Chan Suzanne; Silver Daniel P; Castrillon Diego H; DePinho Ronald A
p16(INK4a) and p53 deficiency cooperate in tumorigenesis.
Cancer research 2002;62(10):2761-5.
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2002: Bachoo Robert M; Maher Elizabeth A; Ligon Keith L; Sharpless Norman E; Chan Suzanne S; You Mingjian James; Tang Yi; DeFrances Jessica; Stover Elizabeth; Weissleder Ralph; Rowitch David H; Louis David N; DePinho Ronald A
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.
Cancer cell 2002;1(3):269-77.
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2002: Alland Leila; David Gregory; Shen-Li Hong; Potes Jason; Muhle Rebecca; Lee Hye-Chun; Hou Harry; Chen Ken; DePinho Ronald A
Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.
Molecular and cellular biology 2002;22(8):2743-50.
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2002: Sviderskaya Elena V; Hill Simon P; Evans-Whipp Tracy J; Chin Lynda; Orlow Seth J; Easty David J; Cheong Sok Ching; Beach David; DePinho Ronald A; Bennett Dorothy C
p16(Ink4a) in melanocyte senescence and differentiation.
Journal of the National Cancer Institute 2002;94(6):446-54.
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2002: You Mingjian James; Castrillon Diego H; Bastian Boris C; O'Hagan Rónán C; Bosenberg Marcus W; Parsons Ramon; Chin Lynda; DePinho Ronald A
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1455-60.
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2002: Bardeesy Nabeel; Morgan Jeffrey; Sinha Manisha; Signoretti Sabina; Srivastava Shefali; Loda Massimo; Merlino Glenn; DePinho Ronald A
Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.
Molecular and cellular biology 2002;22(2):635-43.
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2001: Sharpless N E; Ferguson D O; O'Hagan R C; Castrillon D H; Lee C; Farazi P A; Alson S; Fleming J; Morton C C; Frank K; Chin L; Alt F W; DePinho R A
Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
Molecular cell 2001;8(6):1187-96.
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2001: Yang J; Luan J; Yu Y; Li C; DePinho R A; Chin L; Richmond A
Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame.
Cancer research 2001;61(22):8150-7.
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2001: Sharpless N E; Bardeesy N; Lee K H; Carrasco D; Castrillon D H; Aguirre A J; Wu E A; Horner J W; DePinho R A
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.
Nature 2001;413(6851):86-91.
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2001: Hemann M T; Rudolph K L; Strong M A; DePinho R A; Chin L; Greider C W
Telomere dysfunction triggers developmentally regulated germ cell apoptosis.
Molecular biology of the cell 2001;12(7):2023-30.
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2001: Ranganathan V; Heine W F; Ciccone D N; Rudolph K L; Wu X; Chang S; Hai H; Ahearn I M; Livingston D M; Resnick I; Rosen F; Seemanova E; Jarolim P; DePinho R A; Weaver D T
Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit.
Current biology : CB 2001;11(12):962-6.
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2001: Chang S; Khoo C; DePinho R A
Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouse.
Seminars in cancer biology 2001;11(3):227-39.
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2001: Bardeesy N; Sharpless N E; DePinho R A; Merlino G
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
Seminars in cancer biology 2001;11(3):201-18.
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2001: DePinho R A; Jacks T
Introduction. The laboratory mouse in cancer research.
Seminars in cancer biology 2001;11(3):175-6.
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2001: Kucherlapati R; DePinho R A
Cancer. Telomerase meets its mismatch.
Nature 2001;411(6838):647-8.
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2001: Maher E A; Furnari F B; Bachoo R M; Rowitch D H; Louis D N; Cavenee W K; DePinho R A
Malignant glioma: genetics and biology of a grave matter.
Genes & development 2001;15(11):1311-33.
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2001: Rudolph K L; Millard M; Bosenberg M W; DePinho R A
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans.
Nature genetics 2001;28(2):155-9.
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2001: Martelli F; Hamilton T; Silver D P; Sharpless N E; Bardeesy N; Rokas M; DePinho R A; Livingston D M; Grossman S R
p19ARF targets certain E2F species for degradation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4455-60.
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2001: Lee K H; Rudolph K L; Ju Y J; Greenberg R A; Cannizzaro L; Chin L; Weiler S R; DePinho R A
Telomere dysfunction alters the chemotherapeutic profile of transformed cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3381-6.
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2001: Bardeesy N; Bastian B C; Hezel A; Pinkel D; DePinho R A; Chin L
Dual inactivation of RB and p53 pathways in RAS-induced melanomas.
Molecular and cellular biology 2001;21(6):2144-53.
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2001: de Alboran I M; O'Hagan R C; Gärtner F; Malynn B; Davidson L; Rickert R; Rajewsky K; DePinho R A; Alt F W
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.
Immunity 2001;14(1):45-55.
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2001: Raveh T; Droguett G; Horwitz M S; DePinho R A; Kimchi A
DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.
Nature cell biology 2001;3(1):1-7.
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2001: Zhang S L; DuBois W; Ramsay E S; Bliskovski V; Morse H C; Taddesse-Heath L; Vass W C; DePinho R A; Mock B A
Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility.
Molecular and cellular biology 2001;21(1):310-8.
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2001: Castrillon D H; DePinho R A
Modeling prostate cancer in the mouse.
Advances in cancer research 2001;82():187-204.
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2000: Chang M A; Horner J W; Conklin B R; DePinho R A; Bok D; Zack D J
Tetracycline-inducible system for photoreceptor-specific gene expression.
Investigative ophthalmology & visual science 2000;41(13):4281-7.
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2000: DePinho R A
The age of cancer.
Nature 2000;408(6809):248-54.
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2000: Wong K K; Chang S; Weiler S R; Ganesan S; Chaudhuri J; Zhu C; Artandi S E; Rudolph K L; Gottlieb G J; Chin L; Alt F W; DePinho R A
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.
Nature genetics 2000;26(1):85-8.
-
2000: O'Hagan R C; Ohh M; David G; de Alboran I M; Alt F W; Kaelin W G; DePinho R A
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.
Genes & development 2000;14(17):2185-91.
-
2000: Sherr C J; DePinho R A
Cellular senescence: mitotic clock or culture shock?
Cell 2000;102(4):407-10.
-
2000: Artandi S E; Chang S; Lee S L; Alson S; Gottlieb G J; Chin L; DePinho R A
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice.
Nature 2000;406(6796):641-5.
-
2000: Artandi S E; DePinho R A
Mice without telomerase: what can they teach us about human cancer?
Nature medicine 2000;6(8):852-5.
-
2000: Frank K M; Sharpless N E; Gao Y; Sekiguchi J M; Ferguson D O; Zhu C; Manis J P; Horner J; DePinho R A; Alt F W
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.
Molecular cell 2000;5(6):993-1002.
-
2000: Malynn B A; de Alboran I M; O'Hagan R C; Bronson R; Davidson L; DePinho R A; Alt F W
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.
Genes & development 2000;14(11):1390-9.
-
2000: Ferguson D O; Sekiguchi J M; Chang S; Frank K M; Gao Y; DePinho R A; Alt F W
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6630-3.
-
2000: Albanese C; Reutens A T; Bouzahzah B; Fu M; D'Amico M; Link T; Nicholson R; Depinho R A; Pestell R G
Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(7):877-84.
-
2000: Gagandeep S; Sokhi R; Slehria S; Gorla G R; Furgiuele J; DePinho R A; Gupta S
Hepatocyte transplantation improves survival in mice with liver toxicity induced by hepatic overexpression of Mad1 transcription factor.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(4):358-65.
-
2000: Gao Y; Ferguson D O; Xie W; Manis J P; Sekiguchi J; Frank K M; Chaudhuri J; Horner J; DePinho R A; Alt F W
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.
Nature 2000;404(6780):897-900.
-
2000: Chin L; DePinho R A
Flipping the oncogene switch: illumination of tumor maintenance and regression.
Trends in genetics : TIG 2000;16(4):147-50.
-
2000: Gagandeep S; Ott M; Nisen P D; DePinho R A; Gupta S
Overexpression of Mad transcription factor inhibits proliferation of cultured human hepatocellular carcinoma cells along with tumor formation in immunodeficient animals.
The journal of gene medicine 2000;2(2):117-27.
-
2000: Artandi S E; DePinho R A
A critical role for telomeres in suppressing and facilitating carcinogenesis.
Current opinion in genetics & development 2000;10(1):39-46.
-
2000: Rudolph K L; Chang S; Millard M; Schreiber-Agus N; DePinho R A
Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery.
Science (New York, N.Y.) 2000;287(5456):1253-8.
-
2000: O'Hagan R C; Schreiber-Agus N; Chen K; David G; Engelman J A; Schwab R; Alland L; Thomson C; Ronning D R; Sacchettini J C; Meltzer P; DePinho R A
Gene-target recognition among members of the myc superfamily and implications for oncogenesis.
Nature genetics 2000;24(2):113-9.
-
2000: Shen-Li H; O'Hagan R C; Hou H; Horner J W; Lee H W; DePinho R A
Essential role for Max in early embryonic growth and development.
Genes & development 2000;14(1):17-22.
-
2000: Ferguson D O; Sekiguchi J M; Frank K M; Gao Y; Sharpless N E; Gu Y; Manis J; DePinho R A; Alt F W
The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis.
Cold Spring Harbor symposia on quantitative biology 2000;65():395-403.
-
2000: Bardeesy N; Wong K K; DePinho R A; Chin L
Animal models of melanoma: recent advances and future prospects.
Advances in cancer research 2000;79():123-56.
-
1999: Gopalkrishnan R V; Christiansen K A; Goldstein N I; DePinho R A; Fisher P B
Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells.
Nucleic acids research 1999;27(24):4775-82.
-
1999: DePinho R A; Jacks T
A bumper crop of cancer genes.
Nature genetics 1999;23(3):253-4.
-
1999: Chin L; Tam A; Pomerantz J; Wong M; Holash J; Bardeesy N; Shen Q; O'Hagan R; Pantginis J; Zhou H; Horner J W; Cordon-Cardo C; Yancopoulos G D; DePinho R A
Essential role for oncogenic Ras in tumour maintenance.
Nature 1999;400(6743):468-72.
-
1999: Ghiani C A; Yuan X; Eisen A M; Knutson P L; DePinho R A; McBain C J; Gallo V
Voltage-activated K+ channels and membrane depolarization regulate accumulation of the cyclin-dependent kinase inhibitors p27(Kip1) and p21(CIP1) in glial progenitor cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(13):5380-92.
-
1999: Orlow I; Rabbani F; Chin L; Pomerantz J; Ligeois N; Dudas M; Depinho R; Cordón-Cardó C
Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.
International journal of oncology 1999;15(1):17-24.
-
1999: Chin L; Artandi S E; Shen Q; Tam A; Lee S L; Gottlieb G J; Greider C W; DePinho R A
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis.
Cell 1999;97(4):527-38.
-
1999: Greenberg R A; Chin L; Femino A; Lee K H; Gottlieb G J; Singer R H; Greider C W; DePinho R A
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse.
Cell 1999;97(4):515-25.
-
1999: FitzGerald M J; Arsura M; Bellas R E; Yang W; Wu M; Chin L; Mann K K; DePinho R A; Sonenshein G E
Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc.
Oncogene 1999;18(15):2489-98.
-
1999: Kipling D; Wynford-Thomas D; Jones C J; Akbar A; Aspinall R; Bacchetti S; Blasco M A; Broccoli D; DePinho R A; Edwards D R; Effros R B; Harley C B; Lansdorp P M; Linskens M H; Prowse K R; Newbold R F; Olovnikov A M; Parkinson E K; Pawelec G; Pontén J; Shall S; Zijlmans M; Faragher R G
Telomere-dependent senescence.
Nature biotechnology 1999;17(4):313-4.
-
1999: Rudolph K L; Chang S; Lee H W; Blasco M; Gottlieb G J; Greider C; DePinho R A
Longevity, stress response, and cancer in aging telomerase-deficient mice.
Cell 1999;96(5):701-12.
-
1999: de Lange T; DePinho R A
Unlimited mileage from telomerase?
Science (New York, N.Y.) 1999;283(5404):947-9.
-
1999: Sharpless N E; DePinho R A
The INK4A/ARF locus and its two gene products.
Current opinion in genetics & development 1999;9(1):22-30.
-
1999: Greenberg R A; O'Hagan R C; Deng H; Xiao Q; Hann S R; Adams R R; Lichtsteiner S; Chin L; Morin G B; DePinho R A
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.
Oncogene 1999;18(5):1219-26.
-
1999: Ghiani C A; Eisen A M; Yuan X; DePinho R A; McBain C J; Gallo V
Neurotransmitter receptor activation triggers p27(Kip1 )and p21(CIP1) accumulation and G1 cell cycle arrest in oligodendrocyte progenitors.
Development (Cambridge, England) 1999;126(5):1077-90.
-
1999: Jacobs J J; Kieboom K; Marino S; DePinho R A; van Lohuizen M
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.
Nature 1999;397(6715):164-8.
-
1999: Gómez Lahoz E; Liegeois N J; Zhang P; Engelman J A; Horner J; Silverman A; Burde R; Roussel M F; Sherr C J; Elledge S J; DePinho R A
Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo.
Molecular and cellular biology 1999;19(1):353-63.
-
1998: Holland E C; Hively W P; DePinho R A; Varmus H E
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.
Genes & development 1998;12(23):3675-85.
-
1998: Auer K L; Park J S; Seth P; Coffey R J; Darlington G; Abo A; McMahon M; Depinho R A; Fisher P B; Dent P
Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice.
The Biochemical journal 1998;336 ( Pt 3)():551-60.
-
1998: Chin L; Merlino G; DePinho R A
Malignant melanoma: modern black plague and genetic black box.
Genes & development 1998;12(22):3467-81.
-
1998: Schreiber-Agus N; DePinho R A
Repression by the Mad(Mxi1)-Sin3 complex.
BioEssays : news and reviews in molecular, cellular and developmental biology 1998;20(10):808-18.
-
1998: Radfar A; Unnikrishnan I; Lee H W; DePinho R A; Rosenberg N
p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13194-9.
-
1998: Zhang P; Wong C; DePinho R A; Harper J W; Elledge S J
Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development.
Genes & development 1998;12(20):3162-7.
-
1998: Chin L; Pomerantz J; DePinho R A
The INK4a/ARF tumor suppressor: one gene--two products--two pathways.
Trends in biochemical sciences 1998;23(8):291-6.
-
1998: Schreiber-Agus N; Meng Y; Hoang T; Hou H; Chen K; Greenberg R; Cordon-Cardo C; Lee H W; DePinho R A
Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.
Nature 1998;393(6684):483-7.
-
1998: David G; Alland L; Hong S H; Wong C W; DePinho R A; Dejean A
Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein.
Oncogene 1998;16(19):2549-56.
-
1998: Greenberg R A; Allsopp R C; Chin L; Morin G B; DePinho R A
Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation.
Oncogene 1998;16(13):1723-30.
-
1998: Lee H W; Blasco M A; Gottlieb G J; Horner J W; Greider C W; DePinho R A
Essential role of mouse telomerase in highly proliferative organs.
Nature 1998;392(6676):569-74.
-
1998: Pomerantz J; Schreiber-Agus N; Liégeois N J; Silverman A; Alland L; Chin L; Potes J; Chen K; Orlow I; Lee H W; Cordon-Cardo C; DePinho R A
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.
Cell 1998;92(6):713-23.
-
1998: DePinho R A
Transcriptional repression. The cancer-chromatin connection.
Nature 1998;391(6667):533, 535-6.
-
1998: Watanabe H; Pan Z Q; Schreiber-Agus N; DePinho R A; Hurwitz J; Xiong Y
Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1392-7.
-
1997: Browning J; Horner J W; Pettoello-Mantovani M; Raker C; Yurasov S; DePinho R A; Goldstein H
Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14637-41.
-
1997: Edwards M C; Liegeois N; Horecka J; DePinho R A; Sprague G F; Tyers M; Elledge S J
Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells.
Genetics 1997;147(3):1063-76.
-
1997: Chin L; Pomerantz J; Polsky D; Jacobson M; Cohen C; Cordon-Cardo C; Horner J W; DePinho R A
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo.
Genes & development 1997;11(21):2822-34.
-
1997: Blasco M A; Lee H W; Hande M P; Samper E; Lansdorp P M; DePinho R A; Greider C W
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.
Cell 1997;91(1):25-34.
-
1997: Zhang P; Liégeois N J; Wong C; Finegold M; Hou H; Thompson J C; Silverman A; Harper J W; DePinho R A; Elledge S J
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome.
Nature 1997;387(6629):151-8.
-
1997: Alland L; Muhle R; Hou H; Potes J; Chin L; Schreiber-Agus N; DePinho R A
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.
Nature 1997;387(6628):49-55.
-
1997: Schreiber-Agus N; Stein D; Chen K; Goltz J S; Stevens L; DePinho R A
Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1235-40.
-
1997: Blasco M A; Lee H W; Rizen M; Hanahan D; DePinho R; Greider C W
Mouse models for the study of telomerase.
Ciba Foundation symposium 1997;211():160-70; discussion 170-6.
-
1997: Schreiber-Agus N; Alland L; Muhle R; Goltz J; Chen K; Stevens L; Stein D; DePinho R A
A biochemical and biological analysis of Myc superfamily interactions.
Current topics in microbiology and immunology 1997;224():159-68.
-
1996: Chin L; Liégeois N; DePinho R A; Schreiber-Agus N
Functional interactions among members of the Myc superfamily and potential relevance to cutaneous growth and development.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1996;1(2):128-35.
-
1996: Hatton K S; Mahon K; Chin L; Chiu F C; Lee H W; Peng D; Morgenbesser S D; Horner J; DePinho R A
Expression and activity of L-Myc in normal mouse development.
Molecular and cellular biology 1996;16(4):1794-804.
-
1996: Serrano M; Lee H; Chin L; Cordon-Cardo C; Beach D; DePinho R A
Role of the INK4a locus in tumor suppression and cell mortality.
Cell 1996;85(1):27-37.
-
1996: Rao G; Alland L; Guida P; Schreiber-Agus N; Chen K; Chin L; Rochelle J M; Seldin M F; Skoultchi A I; DePinho R A
Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.
Oncogene 1996;12(5):1165-72.
-
1996: Liégeois N J; Horner J W; DePinho R A
Lens complementation system for the genetic analysis of growth, differentiation, and apoptosis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1303-7.
-
1995: Xu L; Meng Y; Wallen R; DePinho R A
Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype.
Oncogene 1995;11(9):1865-72.
-
1995: Katz E B; Stenbit A E; Hatton K; DePinho R; Charron M J
Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4.
Nature 1995;377(6545):151-5.
-
1995: Chin L; Schreiber-Agus N; Pellicer I; Chen K; Lee H W; Dudast M; Cordon-Cardo C; DePinho R A
Contrasting roles for Myc and Mad proteins in cellular growth and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8488-92.
-
1995: Chen J; Willingham T; Margraf L R; Schreiber-Agus N; DePinho R A; Nisen P D
Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells.
Nature medicine 1995;1(7):638-43.
-
1995: Schreiber-Agus N; Chin L; Chen K; Torres R; Rao G; Guida P; Skoultchi A I; DePinho R A
An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3.
Cell 1995;80(5):777-86.
-
1995: Morgenbesser S D; Schreiber-Agus N; Bidder M; Mahon K A; Overbeek P A; Horner J; DePinho R A
Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.
The EMBO journal 1995;14(4):743-56.
-
1995: Serrano M; Gómez-Lahoz E; DePinho R A; Beach D; Bar-Sagi D
Inhibition of ras-induced proliferation and cellular transformation by p16INK4.
Science (New York, N.Y.) 1995;267(5195):249-52.
-
1994: Schreiber-Agus N; Chin L; Chen K; Torres R; Thomson C T; Sacchettini J C; DePinho R A
Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1.
Oncogene 1994;9(11):3167-77.
-
1994: Morgenbesser S D; Williams B O; Jacks T; DePinho R A
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
Nature 1994;371(6492):72-4.
-
1994: Lahoz E G; Xu L; Schreiber-Agus N; DePinho R A
Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5503-7.
-
1994: Morgenbesser S D; DePinho R A
Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer.
Seminars in cancer biology 1994;5(1):21-36.
-
1994: Williams B O; Morgenbesser S D; DePinho R A; Jacks T
Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53.
Cold Spring Harbor symposia on quantitative biology 1994;59():449-57.
-
1993: Xu L; Wallen R; Patel V; DePinho R A
Role of first exon/intron sequences in the regulation of myc family oncogenic potency.
Oncogene 1993;8(9):2547-53.
-
1993: Schreiber-Agus N; Horner J; Torres R; Chiu F C; DePinho R A
Zebra fish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution.
Molecular and cellular biology 1993;13(5):2765-75.
-
1993: Schreiber-Agus N; Torres R; Horner J; Lau A; Jamrich M; DePinho R A
Comparative analysis of the expression and oncogenic activities of Xenopus c-, N-, and L-myc homologs.
Molecular and cellular biology 1993;13(4):2456-68.
-
1992: Mukherjee B; Morgenbesser S D; DePinho R A
Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants.
Genes & development 1992;6(8):1480-92.
-
1992: Torres R; Schreiber-Agus N; Morgenbesser S D; DePinho R A
Myc and Max: a putative transcriptional complex in search of a cellular target.
Current opinion in cell biology 1992;4(3):468-74.
-
1991: Xu L; Morgenbesser S D; DePinho R A
Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver.
Molecular and cellular biology 1991;11(12):6007-15.
-
1991: DeFranco D; Bali D; Torres R; DePinho R A; Erickson R P; Gluecksohn-Waelsch S
The glucocorticoid hormone signal transduction pathway in mice homozygous for chromosomal deletions causing failure of cell type-specific inducible gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5607-10.
-
1991: Boulton T G; Nye S H; Robbins D J; Ip N Y; Radziejewska E; Morgenbesser S D; DePinho R A; Panayotatos N; Cobb M H; Yancopoulos G D
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
Cell 1991;65(4):663-75.
-
1991: Shin S U; DePinho R; Zack D J; Rudikoff S; Scharff M D
Instability of immunoglobulin genes in S107 cell line.
Somatic cell and molecular genetics 1991;17(3):259-76.
-
1991: Cohen D; Piekarz R L; Hsu S I; DePinho R A; Carrasco N; Horwitz S B
Structural and functional analysis of the mouse mdr1b gene promoter.
The Journal of biological chemistry 1991;266(4):2239-44.
-
1991: DePinho R A; Schreiber-Agus N; Alt F W
myc family oncogenes in the development of normal and neoplastic cells.
Advances in cancer research 1991;57():1-46.
-
1990: Möröy T; Fisher P; Guidos C; Ma A; Zimmerman K; Tesfaye A; DePinho R; Weissman I; Alt F W
IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis.
The EMBO journal 1990;9(11):3659-66.
-
1990: Zimmerman K; Legouy E; Stewart V; Depinho R; Alt F W
Differential regulation of the N-myc gene in transfected cells and transgenic mice.
Molecular and cellular biology 1990;10(5):2096-103.
-
1989: Dildrop R; Ma A; Zimmerman K; Hsu E; Tesfaye A; DePinho R; Alt F W
IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression.
The EMBO journal 1989;8(4):1121-8.
-
1988: Dildrop R; Zimmerman K; DePinho R A; Yancopoulos G D; Tesfaye A; Alt F W
Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice.
Current topics in microbiology and immunology 1988;141():100-9.
-
1987: DePinho R A; Hatton K S; Tesfaye A; Yancopoulos G D; Alt F W
The human myc gene family: structure and activity of L-myc and an L-myc pseudogene.
Genes & development 1987;1(10):1311-26.
-
1987: Legouy E; DePinho R; Zimmerman K; Collum R; Yancopoulos G; Mitsock L; Kriz R; Alt F W
Structure and expression of the murine L-myc gene.
The EMBO journal 1987;6(11):3359-66.
-
1987: Scharff M D; Aguila H L; Behar S M; Chien N C; DePinho R; French D L; Pollock R R; Shin S U
Studies on the somatic instability of immunoglobulin genes in vivo and in cultured cells.
Immunological reviews 1987;96():75-90.
-
1987: DePinho R; Mitsock L; Hatton K; Ferrier P; Zimmerman K; Legouy E; Tesfaye A; Collum R; Yancopoulos G; Nisen P
Myc family of cellular oncogenes.
Journal of cellular biochemistry 1987;33(4):257-66.
-
1986: Yancopoulos G D; DePinho R A; Zimmerman K A; Lutzker S G; Rosenberg N; Alt F W
Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.
The EMBO journal 1986;5(12):3259-66.
-
1986: Bank I; DePinho R A; Brenner M B; Cassimeris J; Alt F W; Chess L
A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes.
Nature 1986;322(6075):179-81.
-
1986: Scharff M D; DePinho R A; Behar S; Beychok C; Shin S U; French D
The role of monoclonal antibodies and the recombinant DNA technology in studying autoantibody production.
Cellular immunology 1986;99(1):29-37.
-
1986: DePinho R A; Legouy E; Feldman L B; Kohl N E; Yancopoulos G D; Alt F W
Structure and expression of the murine N-myc gene.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1827-31.
-
1986: Alt F W; Blackwell T K; DePinho R A; Reth M G; Yancopoulos G D
Regulation of genome rearrangement events during lymphocyte differentiation.
Immunological reviews 1986;89():5-30.
-
1986: DePinho R A; Feldman L B; Scharff M D
Tailor-made monoclonal antibodies.
Annals of internal medicine 1986;104(2):225-33.
-
1986: Kohl N E; Legouy E; DePinho R A; Nisen P D; Smith R K; Gee C E; Alt F W
Human N-myc is closely related in organization and nucleotide sequence to c-myc.
Nature 1986;319(6048):73-7.
-
1986: Depinho R A; Hatton K; Ferrier P; Zimmerman K; Legouy E; Tesfaye A; Collum R; Yancopoulos G; Nisen P; Alt F
Myc family genes: a dispersed multi-gene family.
Annals of clinical research 1986;18(5-6):284-9.
-
1986: Alt F W; DePinho R; Zimmerman K; Legouy E; Hatton K; Ferrier P; Tesfaye A; Yancopoulos G; Nisen P
The human myc gene family.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():931-41.
-
1985: DePinho R A; Kaplan K L
The Hermansky-Pudlak syndrome. Report of three cases and review of pathophysiology and management considerations.
Medicine 1985;64(3):192-202.
-
1984: DePinho R; Kruger K; Andrews N; Lutzker S; Baltimore D; Alt F W
Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line.
Molecular and cellular biology 1984;4(12):2905-10.
-
1984: DePinho R A; Goldberg C S; Lefkowitch J H
Azathioprine and the liver. Evidence favoring idiosyncratic, mixed cholestatic-hepatocellular injury in humans.
Gastroenterology 1984;86(1):162-5.
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