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Wolfgang Deppert

Research Profile

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Genes, p53

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Mukesh Kumar; Jitendra K Meena; Karl-Lenhard Rudolph; Julia M Weise; Britta Witt; Christina Heinlein; Sebastian Iben; Uwe Knippschild; Sylvia Koch; Frauke Krepulat; Florian Kuchenbauer; Wolfgang Deppert; Cagatay Günes
CEBP factors regulate telomerase reverse transcriptase promoter activity in whey acidic protein-T mice during mammary carcinogenesis.
Benjamin Otto; Thomas Streichert; Wolfgang Deppert; Heidrun Gevensleben; Kristin Klätschke; Christoph Wagener; Florian Wegwitz; Genrich V Tolstonog
Transcription factors link mouse WAP-T mammary tumors with human breast cancer.
Benjamin Otto; Klaus Pantel; Udo Schumacher; Reiner Siebert; Thomas Streichert; Lars O Baumbusch; Wolfgang Deppert; Katharina Gruner; Christina Heinlein; José Ignacio Martin-Subero; Peter Nollau; Christoph Wagener; Florian Wegwitz; Bauke Ylstra; Genrich V Tolstonog
Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression.

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2013: Mukesh Kumar; Jitendra K Meena; Karl-Lenhard Rudolph; Julia M Weise; Britta Witt; Christina Heinlein; Sebastian Iben; Uwe Knippschild; Sylvia Koch; Frauke Krepulat; Florian Kuchenbauer; Wolfgang Deppert; Cagatay Günes
CEBP factors regulate telomerase reverse transcriptase promoter activity in whey acidic protein-T mice during mammary carcinogenesis.
International journal of cancer. Journal international du cancer 2013;132(9):2032-43.
2013: Benjamin Otto; Thomas Streichert; Wolfgang Deppert; Heidrun Gevensleben; Kristin Klätschke; Christoph Wagener; Florian Wegwitz; Genrich V Tolstonog
Transcription factors link mouse WAP-T mammary tumors with human breast cancer.
International journal of cancer. Journal international du cancer 2013;132(6):1311-22.
2013: Benjamin Otto; Klaus Pantel; Udo Schumacher; Reiner Siebert; Thomas Streichert; Lars O Baumbusch; Wolfgang Deppert; Katharina Gruner; Christina Heinlein; José Ignacio Martin-Subero; Peter Nollau; Christoph Wagener; Florian Wegwitz; Bauke Ylstra; Genrich V Tolstonog
Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression.
International journal of cancer. Journal international du cancer 2013;132(6):1300-10.
2013: Martin Ruetze; Horst Wenck; Annette Maerz; Volker Achterberg; Wolfgang Deppert; Stefan Gallinat; Tanja Knauer; Anja Knott
A novel niche for skin derived precursors in non-follicular skin.
Journal of dermatological science 2013;69(2):132-9.
2013: Marie Brázdová; Wolfgang Deppert; Matej Adámik; Roman Hrstka; Matej Lexa; Lucie Navrátilová; Kateřina Němcová; Emil Paleček; Petr Pečinka; Vlastimil Tichý; Borivoj Vojtesek; Miroslav Fojta
Preferential Binding of Hot Spot Mutant p53 Proteins to Supercoiled DNA In Vitro and in Cells.
PloS one 2013;8(3):e59567.
2012: Jochen Heukeshoven; Annette März; Wolfgang Deppert; Gabriele Warnecke; Genrich V Tolstonog
Recombinant p53 displays heterogeneity during isoelectric focusing.
Electrophoresis 2012;33(18):2818-27.
2012: Janosch Hildebrand; Anja Knott; Sandra Korge; Florian Spörl; Horst Wenck; Wolfgang Deppert; Stefan Gallinat; Thomas Blatt
Cell cycle regulator Cdkn1c (p57/KIP2) shows distinct expression in epidermal differentiation.
European journal of dermatology : EJD 2012;22(5):694-6.
2012: Timo Quante; Marie Brázdová; Wolfgang Deppert; Iva Kejnovská; Benjamin Otto; Genrich V Tolstonog
Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity.
Cell cycle (Georgetown, Tex.) 2012;11(17):3290-303.
2011: Janosch Hildebrand; Martin Rütze; Nicole Walz; Stefan Gallinat; Horst Wenck; Wolfgang Deppert; Adam Grundhoff; Anja Knott
A comprehensive analysis of microRNA expression during human keratinocyte differentiation in vitro and in vivo.
The Journal of investigative dermatology 2011;131(1):20-9.
2010: Christina Heinlein; Wolfgang Deppert; Antony W Braithwaite; Daniel Speidel
A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry.
Cell cycle (Georgetown, Tex.) 2010;9(17):3584-90.
2010: Genrich V Tolstonog; Wolfgang Deppert
Metabolic sensing by p53: keeping the balance between life and death.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(30):13193-4.
2010: Martin Ruetze; Stefan Gallinat; Horst Wenck; Wolfgang Deppert; Anja Knott
In situ localization of epidermal stem cells using a novel multi epitope ligand cartography approach.
Integrative biology : quantitative biosciences from nano to macro 2010;2(5-6):241-9.
2010: Ella L Kim; Robin Wüstenberg; Anne Rübsam; Christoph Schmitz-Salue; Gabriele Warnecke; Eva-Maria Bücker; Nadine Pettkus; Daniel Speidel; Veit Rohde; Walter Schulz-Schaeffer; Wolfgang Deppert; Alf Giese
Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells.
Neuro-oncology 2010;12(4):389-400.
2010: Florian Wegwitz; Mark-Andreas Kluth; Claudia Mänz; Benjamin Otto; Katharina Gruner; Christina Heinlein; Marion Kühl; Gabriele Warnecke; Udo Schumacher; Wolfgang Deppert; Genrich V Tolstonog
Tumorigenic WAP-T mouse mammary carcinoma cells: a model for a self-reproducing homeostatic cancer cell system.
PloS one 2010;5(8):e12103.
2010: Anja C Utz; Heidrun Hirner; Annette Blatz; Andreas Hillenbrand; Bernhard Schmidt; Wolfgang Deppert; Doris Henne-Bruns; Dietmar Fischer; Dietmar R Thal; Frank Leithäuser; Uwe Knippschild
Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic mice.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2010;58(1):1-15.
2009: Andrea Hermannstädter; Christine Ziegler; Marion Kühl; Wolfgang Deppert; Genrich V Tolstonog
Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation.
Journal of virology 2009;83(19):10106-18.
2009: Genrich V Tolstonog; Wolfgang Deppert
The p53 transcriptional synapse: activation on demand.
Nature structural & molecular biology 2009;16(9):900-1.
2009: Katharina Jannasch; Christian Dullin; Christina Heinlein; Frauke Krepulat; Florian Wegwitz; Wolfgang Deppert; Frauke Alves
Detection of different tumor growth kinetics in single transgenic mice with oncogene-induced mammary carcinomas by flat-panel volume computed tomography.
International journal of cancer. Journal international du cancer 2009;125(1):62-70.
2009: Wolfgang Deppert
Alternatively spliced p53 isoforms: alternative views or alternative functions?
Cell cycle (Georgetown, Tex.) 2009;8(11):1645.
2009: Marie Brázdová; Timo Quante; Lars Tögel; Korden Walter; Christine Loscher; Vlastimil Tichý; Lenka Cincárová; Wolfgang Deppert; Genrich V Tolstonog
Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences.
Nucleic acids research 2009;37(5):1486-500.
2009: Rudolph Reimer; H Helmbold; Beata Szalay; Christian Hagel; Heinz Hohenberg; Wolfgang Deppert; Wolfgang Bohn
Nestin modulates glucocorticoid receptor function by cytoplasmic anchoring.
PloS one 2009;4(6):e6084.
2009: Ella Kim; Alf Giese; Wolfgang Deppert
Wild-type p53 in cancer cells: when a guardian turns into a blackguard.
Biochemical pharmacology 2009;77(1):11-20.
2008: Wolfgang Deppert
SIRT1 protein levels in cancer: tuning SIRT1 to the needs of a cancer cell.
Cell cycle (Georgetown, Tex.) 2008;7(19):2947-8.
2008: Christina Heinlein; Frauke Krepulat; Jürgen Löhler; Daniel Speidel; Wolfgang Deppert; Genrich V Tolstonog
Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis.
International journal of cancer. Journal international du cancer 2008;122(8):1701-9.
2008: A Engelmann; Daniel Speidel; G W Bornkamm; Wolfgang Deppert; Carol Stocking
Gadd45 beta is a pro-survival factor associated with stress-resistant tumors.
Oncogene 2008;27(10):1429-38.
2008: K Henning; J Heering; Ralf Schwanbeck; Timm Schroeder; H Helmbold; Heiner Schäfer; Wolfgang Deppert; E Kim; Ursula Just
Notch1 activation reduces proliferation in the multipotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53.
Cell death and differentiation 2008;15(2):398-407.
2007: Nikola Baschuk; Olaf Utermöhlen; Roland Gugel; Gabriele Warnecke; Ulrike Karow; Daniela Paulsen; Frank Brombacher; Martin Krönke; Wolfgang Deppert
Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice.
Cancer immunology, immunotherapy : CII 2007;56(10):1625-36.
2007: Wolfgang Deppert
Mutant p53: from guardian to fallen angel?
Oncogene 2007;26(15):2142-4.
2006: H Helmbold; Wolfgang Deppert; Wolfgang Bohn
Regulation of cellular senescence by Rb2/p130.
Oncogene 2006;25(38):5257-62.
2006: Kohei Miyazono; Fuyuki Ishikawa; Elke Winterhager; Wolfgang Deppert; Manfred F Rajewsky
Tenth Japanese-German Workshop on Molecular and Cellular Aspects of Carcinogenesis, Essen, Germany, 29 September-1 October 2005.
Cancer science 2006;97(4):332-9.
2006: Daniel Speidel; H Helmbold; Wolfgang Deppert
Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress.
Oncogene 2006;25(6):940-53.
2006: A Kapić; H Helmbold; R Reimer; O Klotzsche; Wolfgang Deppert; Wolfgang Bohn
Cooperation between p53 and p130(Rb2) in induction of cellular senescence.
Cell death and differentiation 2006;13(2):324-34.
2006: Lars O Baumbusch; Simen Myhre; Anita Langerød; Anna Bergamaschi; Stephanie Beate Geisler; Per Eystein Lønning; Wolfgang Deppert; Irene Dornreiter; Anne-Lise Børresen-Dale
Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters.
Molecular cancer 2006;5():47.
2005: Korden Walter; Gabriele Warnecke; Richard P Bowater; Wolfgang Deppert; Ella Kim
tumor suppressor p53 binds with high affinity to CTG.CAG trinucleotide repeats and induces topological alterations in mismatched duplexes.
The Journal of biological chemistry 2005;280(52):42497-507.
2005: Ute M Moll; Sonja Wolff; Daniel Speidel; Wolfgang Deppert
Transcription-independent pro-apoptotic functions of p53.
Current opinion in cell biology 2005;17(6):631-6.
2005: Martin Stöter; Ana-Maria Bamberger; Bilnaz Aslan; Marion Kurth; Daniel Speidel; Thomas Löning; Hans-Georg Frank; Peter Kaufmann; Jürgen Löhler; Doris Henne-Bruns; Wolfgang Deppert; Uwe Knippschild
Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells.
Oncogene 2005;24(54):7964-75.
2005: Gabor Rohaly; Jan Chemnitz; Silke Dehde; Alejandro Mena Nunez; Jochen Heukeshoven; Wolfgang Deppert; Irena Dornreiter
A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint.
Cell 2005;122(1):21-32.
2005: Frauke Krepulat; Jürgen Löhler; Christina Heinlein; Andrea Hermannstädter; Genrich V Tolstonog; Wolfgang Deppert
Epigenetic mechanisms affect mutant p53 transgene expression in WAP-mutp53 transgenic mice.
Oncogene 2005;24(29):4645-59.
2005: Sven Hanson; Ella Kim; Wolfgang Deppert
Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization.
Oncogene 2005;24(9):1641-7.
2005: Julia M Ritz; Olaf Kühle; Sabine Riethdorf; Bence Sipos; Wolfgang Deppert; Christoph Englert; Cagatay Günes
A novel transgenic mouse model reveals humanlike regulation of an 8-kbp human TERT gene promoter fragment in normal and tumor tissues.
Cancer research 2005;65(4):1187-96.
2005: E L Kim; Kimio Yoshizato; Lan Kluwe; Hildegard Meissner; Gabriele Warnecke; Svenja Zapf; Manfred Westphal; Wolfgang Deppert; Alf Giese
Comparative assessment of the functional p53 status in glioma cells.
Anticancer research 2005;25(1A):213-24.
2005: Thomas Göhler; Stefan Jäger; Gabriele Warnecke; Hideyo Yasuda; Ella Kim; Wolfgang Deppert
Mutant p53 proteins bind DNA in a DNA structure-selective mode.
Nucleic acids research 2005;33(3):1087-100.
2004: Ella Kim; Wolfgang Deppert
Transcriptional activities of mutant p53: when mutations are more than a loss.
Journal of cellular biochemistry 2004;93(5):878-86.
2004: Kohei Miyazono; Fuyuki Ishikawa; Elke Winterhager; Wolfgang Deppert; Manfred F Rajewsky
Ninth Japanese-German Workshop on Molecular and Cellular Aspects of Carcinogenesis, Essen, Germany, 18-20 September, 2003.
Cancer science 2004;95(3):276-81.
2003: Ella Kim; Willy Günther; Kimio Yoshizato; Hildegard Meissner; Svenja Zapf; Rolf M Nüsing; Hirotaka Yamamoto; Erwin Van Meir; Wolfgang Deppert; Alf Giese
Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1.
Oncogene 2003;22(49):7716-27.
2003: Julian Wölcke; Maurice Reimann; Martin Klumpp; Thomas Göhler; Ella Kim; Wolfgang Deppert
Analysis of p53 "latency" and "activation" by fluorescence correlation spectroscopy. Evidence for different modes of high affinity DNA binding.
The Journal of biological chemistry 2003;278(35):32587-95.
2003: Tanja Maritzen; Jürgen Löhler; Wolfgang Deppert; Uwe Knippschild
Casein kinase I delta (CKIdelta) is involved in lymphocyte physiology.
European journal of cell biology 2003;82(7):369-78.
2003: Ella Kim; Wolfgang Deppert
The complex interactions of p53 with target DNA: we learn as we go.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2003;81(3):141-50.
2003: Stefan Heinrichs; Wolfgang Deppert
Apoptosis or growth arrest: modulation of the cellular response to p53 by proliferative signals.
Oncogene 2003;22(4):555-71.
2002: Thomas Göhler; Maurice Reimann; Dimitry Cherny; Korden Walter; Gabriele Warnecke; Ella Kim; Wolfgang Deppert
Specific interaction of p53 with target binding sites is determined by DNA conformation and is regulated by the C-terminal domain.
The Journal of biological chemistry 2002;277(43):41192-203.
2002: Olivier Sembritzki; Christian Hagel; Katrin Lamszus; Wolfgang Deppert; Wolfgang Bohn
Cytoplasmic localization of wild-type p53 in glioblastomas correlates with expression of vimentin and glial fibrillary acidic protein.
Neuro-oncology 2002;4(3):171-8.
2001: Olaf Utermöhlen; C Schulze-Garg; Gabriele Warnecke; R Gugel; Jürgen Löhler; Wolfgang Deppert
Simian virus 40 large-T-antigen-specific rejection of mKSA tumor cells in BALB/c mice is critically dependent on both strictly tumor-associated, tumor-specific CD8(+) cytotoxic T lymphocytes and CD4(+) T helper cells.
Journal of virology 2001;75(22):10593-602.
2001: Silke Dehde; Gabor Rohaly; O Schub; Heinz Nasheuer; Wolfgang Bohn; Jan Chemnitz; Wolfgang Deppert; Irena Dornreiter
Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replication.
Molecular and cellular biology 2001;21(7):2581-93.
2001: Martin Wagner; Florian R Greten; Christoph K Weber; S Koschnick; T Mattfeldt; Wolfgang Deppert; H Kern; Guido Adler; Roland M Schmid
A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease.
Genes & development 2001;15(3):286-93.
2000: L Behrend; Diane Milne; Martin Stöter; Wolfgang Deppert; Linda E Campbell; David W Meek; Uwe Knippschild
IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects.
Oncogene 2000;19(47):5303-13.
2000: Silke Süsse; Christine Janz; F Janus; Wolfgang Deppert; Lisa Wiesmüller
Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53.
Oncogene 2000;19(39):4500-12.
2000: H Koga; Wolfgang Deppert
Identification of genomic DNA sequences bound by mutant p53 protein (Gly245-->Ser) in vivo.
Oncogene 2000;19(36):4178-83.
2000: L Behrend; Martin Stöter; Marion Kurth; G Rutter; Jochen Heukeshoven; Wolfgang Deppert; Uwe Knippschild
Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus.
European journal of cell biology 2000;79(4):240-51.
2000: K Will; M Neben; T Schmidt-Rose; Wolfgang Deppert; Klaus-Peter Wittern; Jörg Bergemann
P53-dependent UVB responsiveness of human keratinocytes can be altered by cultivation on cell cycle-arrested dermal fibroblasts.
Photochemistry and photobiology 2000;71(3):321-6.
2000: C Schulze-Garg; Jürgen Löhler; Andreas Gocht; Wolfgang Deppert
A transgenic mouse model for the ductal carcinoma in situ (DCIS) of the mammary gland.
Oncogene 2000;19(8):1028-37.
2000: Wolfgang Deppert; Thomas Göhler; H Koga; Ella Kim
Mutant p53: "gain of function" through perturbation of nuclear structure and function?
Journal of cellular biochemistry. Supplement 2000;Suppl 35():115-22.
2000: Wolfgang Deppert
The nuclear matrix as a target for viral and cellular oncogenes.
Critical reviews in eukaryotic gene expression 2000;10(1):45-61.
1999: N Albrechtsen; Irena Dornreiter; Frank Grosse; Ella Kim; Lisa Wiesmüller; Wolfgang Deppert
Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53.
Oncogene 1999;18(53):7706-17.
1999: Ella Kim; Gabor Rohaly; S Heinrichs; D Gimnopoulos; Hildegard Meissner; Wolfgang Deppert
Influence of promoter DNA topology on sequence-specific DNA binding and transactivation by tumor suppressor p53.
Oncogene 1999;18(51):7310-8.
1999: C Dudenhöffer; Marion Kurth; F Janus; Wolfgang Deppert; Lisa Wiesmüller
Dissociation of the recombination control and the sequence-specific transactivation function of P53.
Oncogene 1999;18(42):5773-84.
1999: Wolfgang Deppert
[The tumor suppressor p53: "guardian of our genomes"].
Medizinische Monatsschrift für Pharmazeuten 1999;22(6):166-73.
1999: F Janus; N Albrechtsen; Uwe Knippschild; Lisa Wiesmüller; Frank Grosse; Wolfgang Deppert
Different regulation of the p53 core domain activities 3'-to-5' exonuclease and sequence-specific DNA binding.
Molecular and cellular biology 1999;19(3):2155-68.
1999: C Kühn; F Müller; C Melle; Heinz Nasheuer; F Janus; Wolfgang Deppert; Frank Grosse
Surface plasmon resonance measurements reveal stable complex formation between p53 and DNA polymerase alpha.
Oncogene 1999;18(3):769-74.
1999: F Janus; N Albrechtsen; Irena Dornreiter; Lisa Wiesmüller; Frank Grosse; Wolfgang Deppert
The dual role model for p53 in maintaining genomic integrity.
Cellular and molecular life sciences : CMLS 1999;55(1):12-27.
1998: K Will; Gabriele Warnecke; Lisa Wiesmüller; Wolfgang Deppert
Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairing.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13681-6.
1998: C Dudenhöffer; Gabor Rohaly; K Will; Wolfgang Deppert; Lisa Wiesmüller
Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination.
Molecular and cellular biology 1998;18(9):5332-42.
1998: O Klotzsche; D Etzrodt; Heinz Hohenberg; Wolfgang Bohn; Wolfgang Deppert
Cytoplasmic retention of mutant tsp53 is dependent on an intermediate filament protein (vimentin) scaffold.
Oncogene 1998;16(26):3423-34.
1998: K Will; Gabriele Warnecke; N Albrechtsen; Teni Boulikas; Wolfgang Deppert
High affinity MAR-DNA binding is a common property of murine and human mutant p53.
Journal of cellular biochemistry 1998;69(3):260-70.
1998: G Weidt; Olaf Utermöhlen; Jochen Heukeshoven; F Lehmann-Grube; Wolfgang Deppert
Relationship among immunodominance of single CD8+ T cell epitopes, virus load, and kinetics of primary antiviral CTL response.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):2923-31.
1997: Wilhelm Henning; Gabor Rohaly; T Kolzau; Uwe Knippschild; H Maacke; Wolfgang Deppert
MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection.
Journal of virology 1997;71(10):7609-18.
1997: Ella Kim; N Albrechtsen; Wolfgang Deppert
DNA-conformation is an important determinant of sequence-specific DNA binding by tumor suppressor p53.
Oncogene 1997;15(7):857-69.
1996: J Zerrahn; F Tiemann; Wolfgang Deppert
Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen.
Journal of virology 1996;70(10):6781-9.
1996: Wolfgang Deppert
Binding of MAR-DNA elements by mutant p53: possible implications for its oncogenic functions.
Journal of cellular biochemistry 1996;62(2):172-80.
1996: T Mummenbrauer; F Janus; B Müller; Lisa Wiesmüller; Wolfgang Deppert; Frank Grosse
p53 Protein exhibits 3'-to-5' exonuclease activity.
Cell 1996;85(7):1089-99.
1996: J Zerrahn; O Utermöhlen; Gabriele Warnecke; Wolfgang Deppert; F Lehmann-Grube
Protective immunity in BALB/c mice against the simian virus 40-induced mKSA tumor resulting from injection of recombinant large T antigen. Requirement of CD8+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(10):3919-24.
1996: B F Müller; D Paulsen; Wolfgang Deppert
Specific binding of MAR/SAR DNA-elements by mutant p53.
Oncogene 1996;12(9):1941-52.
1996: Uwe Knippschild; M Oren; Wolfgang Deppert
Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion.
Oncogene 1996;12(8):1755-65.
1996: Lisa Wiesmüller; J Cammenga; Wolfgang Deppert
In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes.
Journal of virology 1996;70(2):737-44.
1995: G Weidt; Wolfgang Deppert; O Utermöhlen; J Heukeshoven; F Lehmann-Grube
Emergence of virus escape mutants after immunization with epitope vaccine.
Journal of virology 1995;69(11):7147-51.
1995: K Will; Gabriele Warnecke; S Bergmann; Wolfgang Deppert
Species- and tissue-specific expression of the C-terminal alternatively spliced form of the tumor suppressor p53.
Nucleic acids research 1995;23(20):4023-8.
1995: F Tiemann; J Zerrahn; Wolfgang Deppert
Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation.
Journal of virology 1995;69(10):6115-21.
1995: J Mosner; T Mummenbrauer; C Bauer; G Sczakiel; Frank Grosse; Wolfgang Deppert
Negative feedback regulation of wild-type p53 biosynthesis.
The EMBO journal 1995;14(18):4442-9.
1995: Uwe Knippschild; T Kolzau; Wolfgang Deppert
Cell-specific transcriptional activation of the mdm2-gene by ectopically expressed wild-type form of a temperature-sensitive mutant p53.
Oncogene 1995;11(4):683-90.
1995: G Weidt; Wolfgang Deppert; S Buchhop; H Dralle; F Lehmann-Grube
Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.
Journal of virology 1995;69(4):2654-8.
1995: Wolfgang Deppert; R Schirmbeck
The nuclear matrix and virus function.
International review of cytology 1995;162A():485-537.
1994: J Mosner; Wolfgang Deppert
p53 and mdm2 are expressed independently during cellular proliferation.
Oncogene 1994;9(11):3321-8.
1994: G Weidt; O Utermöhlen; J Zerrahn; Jörg Reimann; Wolfgang Deppert; F Lehmann-Grube
CD8+ T lymphocyte-mediated antiviral immunity in mice as a result of injection of recombinant viral proteins.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2554-61.
1994: F Tiemann; Wolfgang Deppert
Immortalization of BALB/c mouse embryo fibroblasts alters SV40 large T-antigen interactions with the tumor suppressor p53 and results in a reduced SV40 transformation-efficiency.
Oncogene 1994;9(7):1907-15.
1994: F Tiemann; Wolfgang Deppert
Stabilization of the tumor suppressor p53 during cellular transformation by simian virus 40: influence of viral and cellular factors and biological consequences.
Journal of virology 1994;68(5):2869-78.
1993: J Zerrahn; Uwe Knippschild; T Winkler; Wolfgang Deppert
Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA.
The EMBO journal 1993;12(12):4739-46.
1993: A Otto; Wolfgang Deppert
Upregulation of mdm-2 expression in Meth A tumor cells tolerating wild-type p53.
Oncogene 1993;8(9):2591-603.
1993: Reinhold Schirmbeck; Wolfgang Deppert; E Kury; Jörg Reimann
In vitro expansion distorts the detectable pattern of specific recognition of in vivo primed cytotoxic T lymphocyte populations.
Cellular immunology 1993;149(2):444-9.
1993: Reinhold Schirmbeck; J Zerrahn; A Kuhröber; Wolfgang Deppert; Jörg Reimann
Immunization of mice with the N-terminal (1-272) fragment of simian virus 40 large T antigen (without adjuvants) specifically primes cytotoxic T lymphocytes.
European journal of immunology 1993;23(7):1528-34.
1993: J Zerrahn; Wolfgang Deppert
Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen.
Journal of virology 1993;67(3):1555-63.
1993: R Schirmbeck; A von der Weth; Wolfgang Deppert
Structural requirements for simian virus 40 replication and virion maturation.
Journal of virology 1993;67(2):894-901.
1993: A von der Weth; Wolfgang Deppert
Wild-type p53 is not a negative regulator of simian virus 40 DNA replication in infected monkey cells.
Journal of virology 1993;67(2):886-93.
1992: S N Weissker; B F Müller; A Homfeld; Wolfgang Deppert
Specific and complex interactions of murine p53 with DNA.
Oncogene 1992;7(10):1921-32.
1992: V von Hoyningen-Huene; M Kurth; Wolfgang Deppert
Selection against large T-antigen expression in cells transformed by lymphotropic papova virus.
Virology 1992;190(1):155-67.
1992: J Zerrahn; Wolfgang Deppert; D Weidemann; T Patschinsky; F Richards; J Milner
Correlation between the conformational phenotype of p53 and its subcellular location.
Oncogene 1992;7(7):1371-81.
1992: A von der Weth; Wolfgang Deppert
Lytic infection of primary rhesus kidney cells by simian virus 40.
Virology 1992;189(1):334-9.
1992: T Patschinsky; Uwe Knippschild; Wolfgang Deppert
Species-specific phosphorylation of mouse and rat p53 in simian virus 40-transformed cells.
Journal of virology 1992;66(6):3846-59.
1992: J Mosner; Wolfgang Deppert
Conformational analysis of p53 in resting and concanavalin A-stimulated mouse lymphocytes.
Oncogene 1992;7(4):661-6.
1992: Reinhold Schirmbeck; J Zerrahn; A Kuhröber; E Kury; Wolfgang Deppert; Jörg Reimann
Immunization with soluble simian virus 40 large T antigen induces a specific response of CD3+ CD4- CD8+ cytotoxic T lymphocytes in mice.
European journal of immunology 1992;22(3):759-66.
1991: Wolfgang Deppert; M Kurth; M Graessmann; Adolf Graessmann; Uwe Knippschild
Altered phosphorylation at specific sites confers a mutant phenotype to SV40 wild-type large T antigen in a flat revertant of SV40-transformed cells.
Oncogene 1991;6(10):1931-8.
1991: Uwe Knippschild; J Kiefer; T Patschinsky; Wolfgang Deppert
Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants.
Journal of virology 1991;65(8):4414-23.
1991: R Schirmbeck; Wolfgang Deppert
Structural topography of simian virus 40 DNA replication.
Journal of virology 1991;65(5):2578-88.
1990: K Steinmeyer; H Maacke; Wolfgang Deppert
Cell cycle control by p53 in normal (3T3) and chemically transformed (Meth A) mouse cells. I. Regulation of p53 expression.
Oncogene 1990;5(11):1691-9.
1990: T Patschinsky; Wolfgang Deppert
Phosphorylation of p53 in primary, immortalised and transformed Balb/c mouse cells.
Oncogene 1990;5(7):1071-6.
1990: W Richter; Wolfgang Deppert
The cellular chromatin is an important target for SV40 large T antigen in maintaining the transformed phenotype.
Virology 1990;174(2):543-56.
1990: Wolfgang Deppert; A Von Der Weth
Functional interaction of nuclear transport-defective simian virus 40 large T antigen with chromatin and nuclear matrix.
Journal of virology 1990;64(2):838-46.
1989: A Walser; Y Rinke; Wolfgang Deppert
Only a minor fraction of plasma membrane-associated large T antigen in simian virus 40-transformed mouse tumor cells (mKSA) is exposed on the cell surface.
Journal of virology 1989;63(9):3926-33.
1989: Wolfgang Deppert; T Steinmayer; W Richter
Cooperation of SV40 large T antigen and the cellular protein p53 in maintenance of cell transformation.
Oncogene 1989;4(9):1103-10.
1989: Y Rinke; Wolfgang Deppert
Quantitative analysis of cell surface-associated SV40 large T antigen using a newly developed 3H-protein A binding assay.
Virology 1989;170(2):424-32.
1989: R Schirmbeck; Wolfgang Deppert
Nuclear subcompartmentalization of simian virus 40 large T antigen: evidence for in vivo regulation of biochemical activities.
Journal of virology 1989;63(5):2308-16.
1989: Wolfgang Deppert; T Steinmayer
Metabolic stabilization of p53 in SV40-transformed cells correlates with expression of the transformed phenotype but is independent from complex formation with SV40 large T antigen.
Current topics in microbiology and immunology 1989;144():77-83.
1988: K Steinmeyer; Wolfgang Deppert
DNA binding properties of murine p53.
Oncogene 1988;3(5):501-7.
1988: Reinhold Schirmbeck; Wolfgang Deppert
Analysis of mechanisms controlling the interactions of SV40 large T antigen with the SV40 ORI region.
Virology 1988;165(2):527-38.
1988: Wolfgang Deppert; A Walser; U Klockmann
A subclass of the adenovirus 72K DNA binding protein specifically associating with the cytoskeletal framework of the plasma membrane.
Virology 1988;165(2):457-68.
1987: Wolfgang Deppert; M Haug; T Steinmayer
Modulation of p53 protein expression during cellular transformation with simian virus 40.
Molecular and cellular biology 1987;7(12):4453-63.
1987: Reinhold Schirmbeck; Wolfgang Deppert
Specific interaction of simian virus 40 large T antigen with cellular chromatin and nuclear matrix during the course of infection.
Journal of virology 1987;61(11):3561-9.
1987: M Hinzpeter; Wolfgang Deppert
Analysis of biological and biochemical parameters for chromatin and nuclear matrix association of SV40 large T antigen in transformed cells.
Oncogene 1987;1(2):119-29.
1985: U Klockmann; D F Klessig; Wolfgang Deppert
Similar regulation of the synthesis of adenovirus fiber and of simian virus 40-specific proteins encoded by the helper-defective Ad2+SV40 hybrid viruses Ad2+ND5 and Ad2+ND4del.
Journal of virology 1985;56(3):821-9.
1985: U Klockmann; Wolfgang Deppert
Evidence for transmembrane orientation of acylated simian virus 40 large T antigen.
Journal of virology 1985;56(2):541-8.
1984: U Klockmann; M Staufenbiel; Wolfgang Deppert
Membrane interactions of simian virus 40 large T-antigen: influence of protein sequences and fatty acid acylation.
Molecular and cellular biology 1984;4(8):1542-50.
1983: U Klockmann; Wolfgang Deppert
Acylated simian virus 40-specific proteins in the plasma membrane of HeLa cells infected with adenovirus 2-simian virus 40 hybrid virus Ad2+ND2.
Virology 1983;126(2):717-20.
1983: U Klockmann; Wolfgang Deppert
Acylation: a new post-translational modification specific for plasma membrane-associated simian virus 40 large T-antigen.
FEBS letters 1983;151(2):257-9.
1983: U Klockmann; Wolfgang Deppert
Acylated simian virus 40 large T-antigen: a new subclass associated with a detergent-resistant lamina of the plasma membrane.
The EMBO journal 1983;2(7):1151-7.