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Channing Der

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
34
Cox, Adrienne
18
Quilliam, Lawrence
17
Khosravi-Far, Roya
15
Clark, Geoffrey
13
Campbell, Sharon
13
Buss, Janice
13
Rossman, Kent
11
Sondek, John
11
Westwick, JK
11
Karnoub, Antoine
10
Whitehead, Ian
9
Shields, Janiel
8
Burridge, Keith
7
Shutes, Adam
7
Siderovski, David

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Publications

TOP 3
Madigan James P; Bodemann Brian O; Brady Donita C; Dewar Brian J; Keller Patricia J; Leitges Michael; Philips Mark R; Ridley Anne J; Der Channing J; Cox Adrienne D
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.
Matsuo Yoichi; Campbell Paul M; Brekken Rolf A; Sung Bokyung; Ouellette Michel M; Fleming Jason B; Aggarwal Bharat B; Der Channing J; Guha Sushovan
K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.
Kim T Y; Vigil D; Der C J; Juliano R L
Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility.

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All Publications

2009: Madigan James P; Bodemann Brian O; Brady Donita C; Dewar Brian J; Keller Patricia J; Leitges Michael; Philips Mark R; Ridley Anne J; Der Channing J; Cox Adrienne D
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.
The Biochemical journal 2009;424(1):153-61.
2009: Matsuo Yoichi; Campbell Paul M; Brekken Rolf A; Sung Bokyung; Ouellette Michel M; Fleming Jason B; Aggarwal Bharat B; Der Channing J; Guha Sushovan
K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.
Molecular cancer research : MCR 2009;7(6):799-808.
2009: Kim T Y; Vigil D; Der C J; Juliano R L
Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility.
Cancer metastasis reviews 2009;28(1-2):77-83.
2009: Yeh Jen Jen; Routh Elizabeth D; Rubinas Tara; Peacock Janie; Martin Timothy D; Shen Xiang Jun; Sandler Robert S; Kim Hong Jin; Keku Temitope O; Der Channing J
KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.
Molecular cancer therapeutics 2009;8(4):834-43.
2009: Yang X-Y; Guan M; Vigil D; Der C J; Lowy D R; Popescu N C
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities.
Oncogene 2009;28(11):1401-9.
2009: Cha Jiyoung Y; Maddileti Savitri; Mitin Natalia; Harden T Kendall; Der Channing J
Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform.
The Journal of biological chemistry 2009;284(10):6227-40.
2009: Hanker Ariella B; Healy Kevin D; Nichols Jean; Der Channing J
Romidepsin inhibits Ras-dependent growth transformation of NIH 3T3 fibroblasts and RIE-1 epithelial cells independently of Ras signaling inhibition.
Journal of molecular signaling 2009;4():5.
2009: Willard Francis S; Willard Melinda D; Kimple Adam J; Soundararajan Meera; Oestreich Emily A; Li Xiaoyan; Sowa Nathaniel A; Kimple Randall J; Doyle Declan A; Der Channing J; Zylka Mark J; Snider William D; Siderovski David P
Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.
PloS one 2009;4(3):e4884.
2008: Kim Tai Young; Healy Kevin D; Der Channing J; Sciaky Noah; Bang Yung-Jue; Juliano Rudy L
Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration.
The Journal of biological chemistry 2008;283(47):32762-70.
2008: Roberts Patrick J; Mitin Natalia; Keller Patricia J; Chenette Emily J; Madigan James P; Currin Rachel O; Cox Adrienne D; Wilson Oswald; Kirschmeier Paul; Der Channing J
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.
The Journal of biological chemistry 2008;283(37):25150-63.
2008: Healy Kevin D; Hodgson Louis; Kim Tai-Young; Shutes Adam; Maddileti Savitri; Juliano Rudolph L; Hahn Klaus M; Harden T Kendall; Bang Yung-Jue; Der Channing J
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms.
Molecular carcinogenesis 2008;47(5):326-37.
2008: Cha Jiyoung Y; Lambert Que T; Reuther Gary W; Der Channing J
Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis.
Molecular cancer research : MCR 2008;6(3):435-45.
2008: Campbell Paul M; Lee Kwang M; Ouellette Michel M; Kim Hong Jin; Groehler Angela L; Khazak Vladimir; Der Channing J
Ras-driven transformation of human nestin-positive pancreatic epithelial cells.
Methods in enzymology 2008;439():451-65.
2008: Reiner David J; González-Pérez Vanessa; Der Channing J; Cox Adrienne D
Use of Caenorhabditis elegans to evaluate inhibitors of Ras function in vivo.
Methods in enzymology 2008;439():425-49.
2008: Onesto Cercina; Shutes Adam; Picard Virginie; Schweighoffer Fabien; Der Channing J
Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.
Methods in enzymology 2008;439():111-29.
2008: Hanker Ariella B; Morita Staeci; Repasky Gretchen A; Ross Douglas T; Seitz Robert S; Der Channing J
Tools to study the function of the Ras-related, estrogen-regulated growth inhibitor in breast cancer.
Methods in enzymology 2008;439():53-72.
2007: Shutes Adam; Onesto Cercina; Picard Virginie; Leblond Bertrand; Schweighoffer Fabien; Der Channing J
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.
The Journal of biological chemistry 2007;282(49):35666-78.
2007: Repasky Gretchen A; Zhou Yixing; Morita Staeci; Der Channing J
Ras-mediated intestinal epithelial cell transformation requires cyclooxygenase-2-induced prostaglandin E2 signaling.
Molecular carcinogenesis 2007;46(12):958-70.
2007: Falsetti Samuel C; Wang De-an; Peng Hairuo; Carrico Dora; Cox Adrienne D; Der Channing J; Hamilton Andrew D; Sebti Saïd M
Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.
Molecular and cellular biology 2007;27(22):8003-14.
2007: Mitin Natalia; Betts Laurie; Yohe Marielle E; Der Channing J; Sondek John; Rossman Kent L
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nature structural & molecular biology 2007;14(9):814-23.
2007: Hao Honglin; Muniz-Medina Vanessa M; Mehta Heena; Thomas Nancy E; Khazak Vladimir; Der Channing J; Shields Janiel M
Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.
Molecular cancer therapeutics 2007;6(8):2220-9.
2007: Der Channing J; Van Dyke Terry
Stopping ras in its tracks.
Cell 2007;129(5):855-7.
2007: Roberts P J; Der C J
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.
Oncogene 2007;26(22):3291-310.
2007: Yeh Jen Jen; Der Channing J
Targeting signal transduction in pancreatic cancer treatment.
Expert opinion on therapeutic targets 2007;11(5):673-94.
2007: Yohe Marielle E; Rossman Kent L; Gardner Olivia S; Karnoub Antoine E; Snyder Jason T; Gershburg Svetlana; Graves Lee M; Der Channing J; Sondek John
Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif.
The Journal of biological chemistry 2007;282(18):13813-23.
2007: Campbell Paul M; Groehler Angela L; Lee Kwang M; Ouellette Michel M; Khazak Vladimir; Der Channing J
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.
Cancer research 2007;67(5):2098-106.
2007: Shields Janiel M; Thomas Nancy E; Cregger Melissa; Berger Aaron J; Leslie Michael; Torrice Chad; Hao Honglin; Penland Shannon; Arbiser Jack; Scott Glynis; Zhou Tong; Bar-Eli Menashe; Bear James E; Der Channing J; Kaufmann William K; Rimm David L; Sharpless Norman E
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma.
Cancer research 2007;67(4):1502-12.
2006: Ongusaha Pat P; Kim Hyung-Gu; Boswell Sarah A; Ridley Anne J; Der Channing J; Dotto G Paolo; Kim Young-Bum; Aaronson Stuart A; Lee Sam W
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress.
Current biology : CB 2006;16(24):2466-72.
2006: Lim Kian-Huat; O'Hayer Kevin; Adam Stacey J; Kendall S Disean; Campbell Paul M; Der Channing J; Counter Christopher M
Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.
Current biology : CB 2006;16(24):2385-94.
2006: Loomis Rebecca J; Holmes Derek A; Elms Andrew; Solski Patricia A; Der Channing J; Su Lishan
Citron kinase, a RhoA effector, enhances HIV-1 virion production by modulating exocytosis.
Traffic (Copenhagen, Denmark) 2006;7(12):1643-53.
2006: Chenette Emily J; Mitin Natalia Y; Der Channing J
Multiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activity.
Molecular biology of the cell 2006;17(7):3108-21.
2006: Kelly Patrick; Moeller Benjamin J; Juneja Juhi; Booden Michelle A; Der Channing J; Daaka Yehia; Dewhirst Mark W; Fields Timothy A; Casey Patrick J
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(21):8173-8.
2006: Baines Antonio T; Lim Kian-Huat; Shields Janiel M; Lambert John M; Counter Christopher M; Der Channing J; Cox Adrienne D
Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth.
Methods in enzymology 2006;407():556-74.
2006: Key Megan D; Andres Douglas A; Der Channing J; Repasky Gretchen A
Characterization of RERG: an estrogen-regulated tumor suppressor gene.
Methods in enzymology 2006;407():513-27.
2006: Campbell Paul M; Singh Anurag; Williams Falina J; Frantz Karen; Ulkü Aylin S; Kelley Grant G; Der Channing J
Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis.
Methods in enzymology 2006;407():195-217.
2006: Shutes Adam; Der Channing J
Real-time in vitro measurement of intrinsic and Ras GAP-mediated GTP hydrolysis.
Methods in enzymology 2006;407():9-22.
2006: Shutes Adam; Berzat Anastacia C; Chenette Emily J; Cox Adrienne D; Der Channing J
Biochemical analyses of the Wrch atypical Rho family GTPases.
Methods in enzymology 2006;406():11-26.
2005: Shutes Adam; Der Channing J
Real-time in vitro measurement of GTP hydrolysis.
Methods (San Diego, Calif.) 2005;37(2):183-89.
2005: Capell Brian C; Erdos Michael R; Madigan James P; Fiordalisi James J; Varga Renee; Conneely Karen N; Gordon Leslie B; Der Channing J; Cox Adrienne D; Collins Francis S
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12879-84.
2005: Berzat Anastacia C; Buss Janice E; Chenette Emily J; Weinbaum Carolyn A; Shutes Adam; Der Channing J; Minden Audrey; Cox Adrienne D
Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif.
The Journal of biological chemistry 2005;280(38):33055-65.
2005: Mitin Natalia; Rossman Kent L; Der Channing J
Signaling interplay in Ras superfamily function.
Current biology : CB 2005;15(14):R563-74.
2005: Lim Kian-Huat; Baines Antonio T; Fiordalisi James J; Shipitsin Michail; Feig Larry A; Cox Adrienne D; Der Channing J; Counter Christopher M
Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
Cancer cell 2005;7(6):533-45.
2005: Pruitt Kevin; Ulkü Aylin S; Frantz Karen; Rojas Rafael J; Muniz-Medina Vanessa M; Rangnekar Vivek M; Der Channing J; Shields Janiel M
Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells.
The Journal of biological chemistry 2005;280(24):23363-70.
2005: Chenette Emily J; Abo Arie; Der Channing J
Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase.
The Journal of biological chemistry 2005;280(14):13784-92.
2005: Wennerberg Krister; Rossman Kent L; Der Channing J
The Ras superfamily at a glance.
Journal of cell science 2005;118(Pt 5):843-6.
2005: Rossman Kent L; Der Channing J; Sondek John
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.
Nature reviews. Molecular cell biology 2005;6(2):167-80.
2004: Palmby Todd R; Abe Karon; Karnoub Antoine E; Der Channing J
Vav transformation requires activation of multiple GTPases and regulation of gene expression.
Molecular cancer research : MCR 2004;2(12):702-11.
2004: Zhang Luwen; Zhang Jun; Lambert Que; Der Channing J; Del Valle Luis; Miklossy Judith; Khalili Kamel; Zhou You; Pagano Joseph S
Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties.
Journal of virology 2004;78(23):12987-95.
2004: Singh Anurag; Karnoub Antoine E; Palmby Todd R; Lengyel Ernst; Sondek John; Der Channing J
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation.
Oncogene 2004;23(58):9369-80.
2004: Shutes Adam; Berzat Anastacia C; Cox Adrienne D; Der Channing J
Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase.
Current biology : CB 2004;14(22):2052-6.
2004: Repasky Gretchen A; Chenette Emily J; Der Channing J
Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?
Trends in cell biology 2004;14(11):639-47.
2004: Collette John; Ulku Aylin S; Der Channing J; Jones Anta'Sha; Erickson Ann H
Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells.
International journal of cancer. Journal international du cancer 2004;112(2):190-9.
2004: Huntington Jonathan T; Shields Janiel M; Der Channing J; Wyatt Colby A; Benbow Ulrike; Slingluff Craig L; Brinckerhoff Constance E
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling.
The Journal of biological chemistry 2004;279(32):33168-76.
2004: Eckert Lynn B; Repasky Gretchen A; Ulkü Aylin S; McFall Aidan; Zhou Hong; Sartor Carolyn I; Der Channing J
Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis.
Cancer research 2004;64(13):4585-92.
2004: Ellerbroek Shawn M; Wennerberg Krister; Arthur William T; Dunty Jill M; Bowman Dan R; DeMali Kris A; Der Channing; Burridge Keith
SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis.
Molecular biology of the cell 2004;15(7):3309-19.
2004: Solski Patricia A; Wilder Rhonda S; Rossman Kent L; Sondek John; Cox Adrienne D; Campbell Sharon L; Der Channing J
Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.
The Journal of biological chemistry 2004;279(24):25226-33.
2004: Mitin Natalia Y; Ramocki Melissa B; Zullo Alfred J; Der Channing J; Konieczny Stephen F; Taparowsky Elizabeth J
Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.
The Journal of biological chemistry 2004;279(21):22353-61.
2004: Campbell Paul M; Der Channing J
Oncogenic Ras and its role in tumor cell invasion and metastasis.
Seminars in cancer biology 2004;14(2):105-14.
2004: Aitsebaomo Julius; Wennerberg Krister; Der Channing J; Zhang Chunlian; Kedar Vishram; Moser Martin; Kingsley-Kallesen Michelle L; Zeng Guo-Qing; Patterson Cam
p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation.
The Journal of biological chemistry 2004;279(17):17963-72.
2004: Wennerberg Krister; Der Channing J
Rho-family GTPases: it's not only Rac and Rho (and I like it).
Journal of cell science 2004;117(Pt 8):1301-12.
2004: Karnoub Antoine E; Symons Marc; Campbell Sharon L; Der Channing J
Molecular basis for Rho GTPase signaling specificity.
Breast cancer research and treatment 2004;84(1):61-71.
2004: Booden Michelle A; Eckert Lynn B; Der Channing J; Trejo JoAnn
Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion.
Molecular and cellular biology 2004;24(5):1990-9.
2004: Fuentes Ernesto J; Der Channing J; Lee Andrew L
Ligand-dependent dynamics and intramolecular signaling in a PDZ domain.
Journal of molecular biology 2004;335(4):1105-15.
2003: Sebti Saïd M; Der Channing J
Opinion: Searching for the elusive targets of farnesyltransferase inhibitors.
Nature reviews. Cancer 2003;3(12):945-51.
2003: Ulkü Aylin S; Schäfer Reinhold; Der Channing J
Essential role of Raf in Ras transformation and deregulation of matrix metalloproteinase expression in ovarian epithelial cells.
Molecular cancer research : MCR 2003;1(14):1077-88.
2003: Cox Adrienne D; Der Channing J
The dark side of Ras: regulation of apoptosis.
Oncogene 2003;22(56):8999-9006.
2003: Wozniak Michele A; Desai Radhika; Solski Patricia A; Der Channing J; Keely Patricia J
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix.
The Journal of cell biology 2003;163(3):583-95.
2003: Bai Xianhe; Cerimele Francesca; Ushio-Fukai Masuko; Waqas Muhammad; Campbell Paul M; Govindarajan Baskaran; Der Channing J; Battle Traci; Frank David A; Ye Keqiang; Murad Emma; Dubiel Wolfgang; Soff Gerald; Arbiser Jack L
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.
The Journal of biological chemistry 2003;278(37):35501-7.
2003: Wennerberg Krister; Forget Marie-Annick; Ellerbroek Shawn M; Arthur William T; Burridge Keith; Settleman Jeffrey; Der Channing J; Hansen Steen H
Rnd proteins function as RhoA antagonists by activating p190 RhoGAP.
Current biology : CB 2003;13(13):1106-15.
2003: Fuentes Ernesto J; Karnoub Antoine E; Booden Michelle A; Der Channing J; Campbell Sharon L
Critical role of the pleckstrin homology domain in Dbs signaling and growth regulation.
The Journal of biological chemistry 2003;278(23):21188-96.
2003: Pruitt Wendy M; Karnoub Antoine E; Rakauskas A Corinne; Guipponi Michel; Antonarakis Stylianos E; Kurakin Alexei; Kay Brian K; Sondek John; Siderovski David P; Der Channing J
Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling.
Biochimica et biophysica acta 2003;1640(1):61-8.
2003: Hii Charles S T; Costabile Maurizio; Mayne George C; Der Channing J; Murray Andrew W; Ferrante Antonio
Selective deficiency in protein kinase C isoenzyme expression and inadequacy in mitogen-activated protein kinase activation in cord blood T cells.
The Biochemical journal 2003;370(Pt 2):497-503.
2003: Ulkü Aylin S; Der Channing J
Ras signaling, deregulation of gene expression and oncogenesis.
Cancer treatment and research 2003;115():189-208.
2002: Wennerberg Krister; Ellerbroek Shawn M; Liu Rong-Yu; Karnoub Antoine E; Burridge Keith; Der Channing J
RhoG signals in parallel with Rac1 and Cdc42.
The Journal of biological chemistry 2002;277(49):47810-7.
2002: Cox Adrienne D; Der Channing J
Ras family signaling: therapeutic targeting.
Cancer biology & therapy 2002;1(6):599-606.
2002: Arthur William T; Ellerbroek Shawn M; Der Channing J; Burridge Keith; Wennerberg Krister
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
The Journal of biological chemistry 2002;277(45):42964-72.
2002: Palmby Todd R; Abe Karon; Der Channing J
Critical role of the pleckstrin homology and cysteine-rich domains in Vav signaling and transforming activity.
The Journal of biological chemistry 2002;277(42):39350-9.
2002: Solski Patricia A; Helms Whitney; Keely Patricia J; Su Lishan; Der Channing J
RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2002;13(8):363-73.
2002: Hamad Nesrin M; Elconin Joel H; Karnoub Antoine E; Bai Wenli; Rich Jeremy N; Abraham Robert T; Der Channing J; Counter Christopher M
Distinct requirements for Ras oncogenesis in human versus mouse cells.
Genes & development 2002;16(16):2045-57.
2002: Lambert John M; Lambert Que T; Reuther Gary W; Malliri Angeliki; Siderovski David P; Sondek John; Collard John G; Der Channing J
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.
Nature cell biology 2002;4(8):621-5.
2002: Cox Adrienne D; Der Channing J
Farnesyltransferase inhibitors: promises and realities.
Current opinion in pharmacology 2002;2(4):388-93.
2002: Pruitt Kevin; Pruitt Wendy M; Bilter Graham K; Westwick John K; Der Channing J
Raf-independent deregulation of p38 and JNK mitogen-activated protein kinases are critical for Ras transformation.
The Journal of biological chemistry 2002;277(35):31808-17.
2002: Dwivedi Prem P; Hii Charles S T; Ferrante Antonio; Tan Joseph; Der Channing J; Omdahl John L; Morris Howard A; May Brian K
Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5.
The Journal of biological chemistry 2002;277(33):29643-53.
2002: Reuther Gary W; Lambert Que T; Rebhun John F; Caligiuri Michael A; Quilliam Lawrence A; Der Channing J
RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia.
The Journal of biological chemistry 2002;277(34):30508-14.
2002: Booden Michelle A; Siderovski David P; Der Channing J
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.
Molecular and cellular biology 2002;22(12):4053-61.
2002: Snyder Jason T; Worthylake David K; Rossman Kent L; Betts Laurie; Pruitt Wendy M; Siderovski David P; Der Channing J; Sondek John
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nature structural biology 2002;9(6):468-75.
2002: Booden Michelle A; Campbell Sharon L; Der Channing J
Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation.
Molecular and cellular biology 2002;22(8):2487-97.
2002: Shields Janiel M; Mehta Heena; Pruitt Kevin; Der Channing J
Opposing roles of the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in Ras-mediated downregulation of tropomyosin.
Molecular and cellular biology 2002;22(7):2304-17.
2002: Wolfman Janice C; Palmby Todd; Der Channing J; Wolfman Alan
Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38.
Molecular and cellular biology 2002;22(5):1589-606.
2002: Murphy Gretchen A; Graham Suzanne M; Morita Staeci; Reks Sarah E; Rogers-Graham Kelley; Vojtek Anne; Kelley Grant G; Der Channing J
Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation.
The Journal of biological chemistry 2002;277(12):9966-75.
2002: Shields Janiel M; Rogers-Graham Kelley; Der Channing J
Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways.
The Journal of biological chemistry 2002;277(12):9790-9.
2002: Lambert John M; Karnoub Antoine E; Graves Lee M; Campbell Sharon L; Der Channing J
Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation.
The Journal of biological chemistry 2002;277(7):4770-7.
2001: Karnoub A E; Worthylake D K; Rossman K L; Pruitt W M; Campbell S L; Sondek J; Der C J
Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.
Nature structural biology 2001;8(12):1037-41.
2001: Wing M R; Houston D; Kelley G G; Der C J; Siderovski D P; Harden T K
Activation of phospholipase C-epsilon by heterotrimeric G protein betagamma-subunits.
The Journal of biological chemistry 2001;276(51):48257-61.
2001: Snyder J T; Rossman K L; Baumeister M A; Pruitt W M; Siderovski D P; Der C J; Lemmon M A; Sondek J
Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins.
The Journal of biological chemistry 2001;276(49):45868-75.
2001: Pruitt K; Der C J
Ras and Rho regulation of the cell cycle and oncogenesis.
Cancer letters 2001;171(1):1-10.
2001: McFall A; Ulkü A; Lambert Q T; Kusa A; Rogers-Graham K; Der C J
Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase.
Molecular and cellular biology 2001;21(16):5488-99.
2001: Reuther G W; Lambert Q T; Booden M A; Wennerberg K; Becknell B; Marcucci G; Sondek J; Caligiuri M A; Der C J
Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA.
The Journal of biological chemistry 2001;276(29):27145-51.
2001: Martin C B; Mahon G M; Klinger M B; Kay R J; Symons M; Der C J; Whitehead I P
The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways.
Oncogene 2001;20(16):1953-63.
2001: Karnoub A E; Der C J; Campbell S L
The insert region of Rac1 is essential for membrane ruffling but not cellular transformation.
Molecular and cellular biology 2001;21(8):2847-57.
2001: Whitehead I P; Zohn I E; Der C J
Rho GTPase-dependent transformation by G protein-coupled receptors.
Oncogene 2001;20(13):1547-55.
2001: Graham S M; Rogers-Graham K; Figueroa C; Der C J; Vojtek A B
Analyses of TC21/R-Ras2 signaling and biological activity.
Methods in enzymology 2001;333():203-16.
2001: Fiordalisi J J; Johnson R L; Ulkü A S; Der C J; Cox A D
Mammalian expression vectors for Ras family proteins: generation and use of expression constructs to analyze Ras family function.
Methods in enzymology 2001;332():3-36.
2001: Shields J M; Der C J; Powers S
Identification of Ras-regulated genes by representational difference analysis.
Methods in enzymology 2001;332():221-32.
2000: Gupta S; Plattner R; Der C J; Stanbridge E J
Dissection of Ras-dependent signaling pathways controlling aggressive tumor growth of human fibrosarcoma cells: evidence for a potential novel pathway.
Molecular and cellular biology 2000;20(24):9294-306.
2000: Reuther G W; Lambert Q T; Caligiuri M A; Der C J
Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia.
Molecular and cellular biology 2000;20(23):8655-66.
2000: Pruitt K; Pestell R G; Der C J
Ras inactivation of the retinoblastoma pathway by distinct mechanisms in NIH 3T3 fibroblast and RIE-1 epithelial cells.
The Journal of biological chemistry 2000;275(52):40916-24.
2000: Zohn I E; Klinger M; Karp X; Kirk H; Symons M; Chrzanowska-Wodnicka M; Der C J; Kay R J
G2A is an oncogenic G protein-coupled receptor.
Oncogene 2000;19(34):3866-77.
2000: Williams J G; Drugan J K; Yi G S; Clark G J; Der C J; Campbell S L
Elucidation of binding determinants and functional consequences of Ras/Raf-cysteine-rich domain interactions.
The Journal of biological chemistry 2000;275(29):22172-9.
2000: Abe K; Rossman K L; Liu B; Ritola K D; Chiang D; Campbell S L; Burridge K; Der C J
Vav2 is an activator of Cdc42, Rac1, and RhoA.
The Journal of biological chemistry 2000;275(14):10141-9.
2000: Shields J M; Pruitt K; McFall A; Shaub A; Der C J
Understanding Ras: 'it ain't over 'til it's over'.
Trends in cell biology 2000;10(4):147-54.
2000: Reuther G W; Der C J
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
Current opinion in cell biology 2000;12(2):157-65.
2000: Reuther G W; Buss J E; Quilliam L A; Clark G J; Der C J
Analysis of function and regulation of proteins that mediate signal transduction by use of lipid-modified plasma membrane-targeting sequences.
Methods in enzymology 2000;327():331-50.
2000: Solski P A; Abe K; Der C J
Analyses of transforming activity of Rho family activators.
Methods in enzymology 2000;325():425-41.
1999: Zhang H; Wang L; Kao S; Whitehead I P; Hart M J; Liu B; Duus K; Burridge K; Der C J; Su L
Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF.
Current biology : CB 1999;9(21):1271-4.
1999: Whitehead I P; Lambert Q T; Glaven J A; Abe K; Rossman K L; Mahon G M; Trzaskos J M; Kay R; Campbell S L; Der C J
Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation.
Molecular and cellular biology 1999;19(11):7759-70.
1999: Abe K; Whitehead I P; O'Bryan J P; Der C J
Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity.
The Journal of biological chemistry 1999;274(43):30410-8.
1999: Sizemore N; Cox A D; Barnard J A; Oldham S M; Reynolds E R; Der C J; Coffey R J
Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor-related peptides.
Gastroenterology 1999;117(3):567-76.
1999: Quilliam L A; Castro A F; Rogers-Graham K S; Martin C B; Der C J; Bi C
M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6.
The Journal of biological chemistry 1999;274(34):23850-7.
1999: Graham S M; Oldham S M; Martin C B; Drugan J K; Zohn I E; Campbell S; Der C J
TC21 and Ras share indistinguishable transforming and differentiating activities.
Oncogene 1999;18(12):2107-16.
1999: Li Y Q; Hii C S; Costabile M; Goh D; Der C J; Ferrante A
Regulation of lymphotoxin production by the p21ras-raf-MEK-ERK cascade in PHA/PMA-stimulated Jurkat cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3316-20.
1998: Tognon C E; Kirk H E; Passmore L A; Whitehead I P; Der C J; Kay R J
Regulation of RasGRP via a phorbol ester-responsive C1 domain.
Molecular and cellular biology 1998;18(12):6995-7008.
1998: Vojtek A B; Der C J
Increasing complexity of the Ras signaling pathway.
The Journal of biological chemistry 1998;273(32):19925-8.
1998: Whitehead I P; Abe K; Gorski J L; Der C J
CDC42 and FGD1 cause distinct signaling and transforming activities.
Molecular and cellular biology 1998;18(8):4689-97.
1998: Hii C S; Huang Z H; Bilney A; Costabile M; Murray A W; Rathjen D A; Der C J; Ferrante A
Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for cell type-specific activation of mitogen-activated protein kinases.
The Journal of biological chemistry 1998;273(30):19277-82.
1998: Westwick J K; Lee R J; Lambert Q T; Symons M; Pestell R G; Der C J; Whitehead I P
Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun.
The Journal of biological chemistry 1998;273(27):16739-47.
1998: Oldham S M; Cox A D; Reynolds E R; Sizemore N S; Coffey R J; Der C J
Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade.
Oncogene 1998;16(20):2565-73.
1998: Zohn I E; Symons M; Chrzanowska-Wodnicka M; Westwick J K; Der C J
Mas oncogene signaling and transformation require the small GTP-binding protein Rac.
Molecular and cellular biology 1998;18(3):1225-35.
1997: Keely P J; Westwick J K; Whitehead I P; Der C J; Parise L V
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.
Nature 1997;390(6660):632-6.
1997: Finco T S; Westwick J K; Norris J L; Beg A A; Der C J; Baldwin A S
Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation.
The Journal of biological chemistry 1997;272(39):24113-6.
1997: Cox A D; Der C J
Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?
Biochimica et biophysica acta 1997;1333(1):F51-71.
1997: Clark G J; Drugan J K; Rossman K L; Carpenter J W; Rogers-Graham K; Fu H; Der C J; Campbell S L
14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain.
The Journal of biological chemistry 1997;272(34):20990-3.
1997: Gangarosa L M; Sizemore N; Graves-Deal R; Oldham S M; Der C J; Coffey R J
A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells.
The Journal of biological chemistry 1997;272(30):18926-31.
1997: Clark G J; Kinch M S; Rogers-Graham K; Sebti S M; Hamilton A D; Der C J
The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.
The Journal of biological chemistry 1997;272(16):10608-15.
1997: Han J; Das B; Wei W; Van Aelst L; Mosteller R D; Khosravi-Far R; Westwick J K; Der C J; Broek D
Lck regulates Vav activation of members of the Rho family of GTPases.
Molecular and cellular biology 1997;17(3):1346-53.
1997: Westwick J K; Lambert Q T; Clark G J; Symons M; Van Aelst L; Pestell R G; Der C J
Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways.
Molecular and cellular biology 1997;17(3):1324-35.
1997: Whitehead I P; Campbell S; Rossman K L; Der C J
Dbl family proteins.
Biochimica et biophysica acta 1997;1332(1):F1-23.
1997: Huff S Y; Quilliam L A; Cox A D; Der C J
R-Ras is regulated by activators and effectors distinct from those that control Ras function.
Oncogene 1997;14(2):133-43.
1997: Clark G J; Westwick J K; Der C J
p120 GAP modulates Ras activation of Jun kinases and transformation.
The Journal of biological chemistry 1997;272(3):1677-81.
1996: Willumsen B M; Cox A D; Solski P A; Der C J; Buss J E
Novel determinants of H-Ras plasma membrane localization and transformation.
Oncogene 1996;13(9):1901-9.
1996: Biscardi J S; Denhez F; Buehler G F; Chesnutt D A; Baragona S C; O'Bryan J P; Der C J; Fiordalisi J J; Fults D W; Maness P F
Rek, a gene expressed in retina and brain, encodes a receptor tyrosine kinase of the Axl/Tyro3 family.
The Journal of biological chemistry 1996;271(46):29049-59.
1996: Quilliam L A; Lambert Q T; Mickelson-Young L A; Westwick J K; Sparks A B; Kay B K; Jenkins N A; Gilbert D J; Copeland N G; Der C J
Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling.
The Journal of biological chemistry 1996;271(46):28772-6.
1996: Graham S M; Vojtek A B; Huff S Y; Cox A D; Clark G J; Cooper J A; Der C J
TC21 causes transformation by Raf-independent signaling pathways.
Molecular and cellular biology 1996;16(11):6132-40.
1996: Oldham S M; Clark G J; Gangarosa L M; Coffey R J; Der C J
Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):6924-8.
1996: Khosravi-Far R; White M A; Westwick J K; Solski P A; Chrzanowska-Wodnicka M; Van Aelst L; Wigler M H; Der C J
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.
Molecular and cellular biology 1996;16(7):3923-33.
1996: Chen Q; Lin T H; Der C J; Juliano R L
Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected]
The Journal of biological chemistry 1996;271(30):18122-7.
1996: O'Bryan J P; Martin C B; Songyang Z; Cantley L C; Der C J
Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.
The Journal of biological chemistry 1996;271(20):11787-91.
1996: Quilliam L A; Hisaka M M; Zhong S; Lowry A; Mosteller R D; Han J; Drugan J K; Broek D; Campbell S L; Der C J
Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.
The Journal of biological chemistry 1996;271(19):11076-82.
1996: Galang C K; García-Ramírez J; Solski P A; Westwick J K; Der C J; Neznanov N N; Oshima R G; Hauser C A
Oncogenic Neu/ErbB-2 increases ets, AP-1, and NF-kappaB-dependent gene expression, and inhibiting ets activation blocks Neu-mediated cellular transformation.
The Journal of biological chemistry 1996;271(14):7992-8.
1996: O'Bryan J P; Songyang Z; Cantley L; Der C J; Pawson T
A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2729-34.
1996: Chu Y; Solski P A; Khosravi-Far R; Der C J; Kelly K
The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation.
The Journal of biological chemistry 1996;271(11):6497-501.
1996: Clark G J; Drugan J K; Terrell R S; Bradham C; Der C J; Bell R M; Campbell S
Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1577-81.
1996: Clark G J; Kinch M S; Gilmer T M; Burridge K; Der C J
Overexpression of the Ras-related TC21/R-Ras2 protein may contribute to the development of human breast cancers.
Oncogene 1996;12(1):169-76.
1996: Drugan J K; Khosravi-Far R; White M A; Der C J; Sung Y J; Hwang Y W; Campbell S L
Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation.
The Journal of biological chemistry 1996;271(1):233-7.
1996: Fridell Y W; Jin Y; Quilliam L A; Burchert A; McCloskey P; Spizz G; Varnum B; Der C; Liu E T
Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase.
Molecular and cellular biology 1996;16(1):135-45.
1995: Overbeck A F; Brtva T R; Cox A D; Graham S M; Huff S Y; Khosravi-Far R; Quilliam L A; Solski P A; Der C J
Guanine nucleotide exchange factors: activators of Ras superfamily proteins.
Molecular reproduction and development 1995;42(4):468-76.
1995: Lerner E C; Qian Y; Blaskovich M A; Fossum R D; Vogt A; Sun J; Cox A D; Der C J; Hamilton A D; Sebti S M
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
The Journal of biological chemistry 1995;270(45):26802-6.
1995: Khosravi-Far R; Solski P A; Clark G J; Kinch M S; Der C J
Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation.
Molecular and cellular biology 1995;15(11):6443-53.
1995: Clark G J; Der C J
Aberrant function of the Ras signal transduction pathway in human breast cancer.
Breast cancer research and treatment 1995;35(1):133-44.
1995: Kinch M S; Clark G J; Der C J; Burridge K
Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.
The Journal of cell biology 1995;130(2):461-71.
1995: Prendergast G C; Khosravi-Far R; Solski P A; Kurzawa H; Lebowitz P F; Der C J
Critical role of Rho in cell transformation by oncogenic Ras.
Oncogene 1995;10(12):2289-96.
1995: Quilliam L A; Khosravi-Far R; Huff S Y; Der C J
Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins.
BioEssays : news and reviews in molecular, cellular and developmental biology 1995;17(5):395-404.
1995: Wang H G; Millan J A; Cox A D; Der C J; Rapp U R; Beck T; Zha H; Reed J C
R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.
The Journal of cell biology 1995;129(4):1103-14.
1995: Brtva T R; Drugan J K; Ghosh S; Terrell R S; Campbell-Burk S; Bell R M; Der C J
Two distinct Raf domains mediate interaction with Ras.
The Journal of biological chemistry 1995;270(17):9809-12.
1995: Quilliam L A; Zhong S; Rabun K M; Carpenter J W; South T L; Der C J; Campbell-Burk S
Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1272-6.
1995: Khosravi-Far R; Der C J
Prenylation analysis of bacterially expressed and insect cell-expressed Ras and Ras-related proteins.
Methods in enzymology 1995;255():46-60.
1995: Clark G J; Cox A D; Graham S M; Der C J
Biological assays for Ras transformation.
Methods in enzymology 1995;255():395-412.
1995: Cox A D; Solski P A; Jordan J D; Der C J
Analysis of Ras protein expression in mammalian cells.
Methods in enzymology 1995;255():195-220.
1995: Solski P A; Quilliam L A; Coats S G; Der C J; Buss J E
Targeting proteins to membranes using signal sequences for lipid modification.
Methods in enzymology 1995;250():435-54.
1994: Cox A D; Brtva T R; Lowe D G; Der C J
R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells.
Oncogene 1994;9(11):3281-8.
1994: Galang C K; Der C J; Hauser C A
Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites.
Oncogene 1994;9(10):2913-21.
1994: Khosravi-Far R; Chrzanowska-Wodnicka M; Solski P A; Eva A; Burridge K; Der C J
Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.
Molecular and cellular biology 1994;14(10):6848-57.
1994: Sparks A B; Quilliam L A; Thorn J M; Der C J; Kay B K
Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries.
The Journal of biological chemistry 1994;269(39):23853-6.
1994: Quilliam L A; Huff S Y; Rabun K M; Wei W; Park W; Broek D; Der C J
Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8512-6.
1994: Cox A D; Garcia A M; Westwick J K; Kowalczyk J J; Lewis M D; Brenner D A; Der C J
The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation.
The Journal of biological chemistry 1994;269(30):19203-6.
1994: Graham S M; Cox A D; Drivas G; Rush M G; D'Eustachio P; Der C J
Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.
Molecular and cellular biology 1994;14(6):4108-15.
1994: Westwick J K; Cox A D; Der C J; Cobb M H; Hibi M; Karin M; Brenner D A
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6030-4.
1994: Khosravi-Far R; Der C J
The Ras signal transduction pathway.
Cancer metastasis reviews 1994;13(1):67-89.
1994: Quilliam L A; Kato K; Rabun K M; Hisaka M M; Huff S Y; Campbell-Burk S; Der C J
Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors.
Molecular and cellular biology 1994;14(2):1113-21.
1994: Pankov R; Umezawa A; Maki R; Der C J; Hauser C A; Oshima R G
Oncogene activation of human keratin 18 transcription via the Ras signal transduction pathway.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(3):873-7.
1994: Cox A D; Der C J
Biological assays for cellular transformation.
Methods in enzymology 1994;238():277-94.
1994: Hauser C A; Der C J; Cox A D
Transcriptional activation analysis of oncogene function.
Methods in enzymology 1994;238():271-6.
1993: Pendergast A M; Quilliam L A; Cripe L D; Bassing C H; Dai Z; Li N; Batzer A; Rabun K M; Der C J; Schlessinger J
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein.
Cell 1993;75(1):175-85.
1993: Clark G J; Quilliam L A; Hisaka M M; Der C J
Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):4887-91.
1993: Cox A D; Graham S M; Solski P A; Buss J E; Der C J
The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity.
The Journal of biological chemistry 1993;268(16):11548-52.
1993: Bokoch G M; Der C J
Emerging concepts in the Ras superfamily of GTP-binding proteins.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(9):750-9.
1992: Cox A D; Der C J
Protein prenylation: more than just glue?
Current opinion in cell biology 1992;4(6):1008-16.
1992: Khosravi-Far R; Clark G J; Abe K; Cox A D; McLain T; Lutz R J; Sinensky M; Der C J
Ras (CXXX) and Rab (CC/CXC) prenylation signal sequences are unique and functionally distinct.
The Journal of biological chemistry 1992;267(34):24363-8.
1992: Tisdale E J; Bourne J R; Khosravi-Far R; Der C J; Balch W E
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.
The Journal of cell biology 1992;119(4):749-61.
1992: Kato K; Der C J; Buss J E
Prenoids and palmitate: lipids that control the biological activity of Ras proteins.
Seminars in cancer biology 1992;3(4):179-88.
1992: Chow M; Der C J; Buss J E
Structure and biological effects of lipid modifications on proteins.
Current opinion in cell biology 1992;4(4):629-36.
1992: Kato K; Cox A D; Hisaka M M; Graham S M; Buss J E; Der C J
Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6403-7.
1992: Khosravi-Far R; Cox A D; Kato K; Der C J
Protein prenylation: key to ras function and cancer intervention?
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(7):461-9.
1992: Cox A D; Hisaka M M; Buss J E; Der C J
Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.
Molecular and cellular biology 1992;12(6):2606-15.
1992: Patel G; MacDonald M J; Khosravi-Far R; Hisaka M M; Der C J
Alternate mechanisms of ras activation are complementary and favor and formation of ras-GTP.
Oncogene 1992;7(2):283-8.
1991: Plutner H; Cox A D; Pind S; Khosravi-Far R; Bourne J R; Schwaninger R; Der C J; Balch W E
Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.
The Journal of cell biology 1991;115(1):31-43.
1991: Khosravi-Far R; Lutz R J; Cox A D; Conroy L; Bourne J R; Sinensky M; Balch W E; Buss J E; Der C J
Isoprenoid modification of rab proteins terminating in CC or CXC motifs.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6264-8.
1991: Buss J E; Quilliam L A; Kato K; Casey P J; Solski P A; Wong G; Clark R; McCormick F; Bokoch G M; Der C J
The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein.
Molecular and cellular biology 1991;11(3):1523-30.
1990: Jackson J H; Cochrane C G; Bourne J R; Solski P A; Buss J E; Der C J
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3042-6.
1990: Quilliam L A; Der C J; Brown J H
GTP-binding protein-stimulated phospholipase C and phospholipase D activities in ras-transformed NIH 3T3 fibroblasts.
Second messengers and phosphoproteins 1990;13(1):59-67.
1989: Casey P J; Solski P A; Der C J; Buss J E
p21ras is modified by a farnesyl isoprenoid.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8323-7.
1989: Chen W S; Lazar C S; Lund K A; Welsh J B; Chang C P; Walton G M; Der C J; Wiley H S; Gill G N; Rosenfeld M G
Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation.
Cell 1989;59(1):33-43.
1989: Buss J E; Solski P A; Schaeffer J P; MacDonald M J; Der C J
Activation of cellular p21ras by myristoylation.
Biochemical Society transactions 1989;17(5):867-9.
1989: Buss J E; Solski P A; Schaeffer J P; MacDonald M J; Der C J
Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal.
Science (New York, N.Y.) 1989;243(4898):1600-3.
1988: Buss J E; Der C J; Solski P A
The six amino-terminal amino acids of p60src are sufficient to cause myristylation of p21v-ras.
Molecular and cellular biology 1988;8(9):3960-3.

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