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R H W M Derksen

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Henk A Martens; G J Navis; H L A Nienhuis; I M Nolte; G van der Steege; A E Voskuyl; E Brouwer; Ruud G L de Sévaux; R H W M Derksen; S Gross; C G M Kallenberg; J H M Berden; S P Berger; M Bijl
Receptor for advanced glycation end products (RAGE) polymorphisms are associated with systemic lupus erythematosus and disease severity in lupus nephritis.
Suzanne Arends; Jo H M Berden; Stefan P Berger; Marc Bijl; Ruud G L de Sévaux; R H W M Derksen; Cecile Grootscholten; Alexandre E Voskuyl
Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis.
Anne van Tellingen; Marc G Vervloet; A E Voskuyl; J H M Berden; S P Berger; M Bijl; R G L de Sévaux; R H W M Derksen
Dutch guidelines for diagnosis and therapy of proliferative lupus nephritis.

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2012: Henk A Martens; G J Navis; H L A Nienhuis; I M Nolte; G van der Steege; A E Voskuyl; E Brouwer; Ruud G L de Sévaux; R H W M Derksen; S Gross; C G M Kallenberg; J H M Berden; S P Berger; M Bijl
Receptor for advanced glycation end products (RAGE) polymorphisms are associated with systemic lupus erythematosus and disease severity in lupus nephritis.
Lupus 2012;21(9):959-68.
2012: Suzanne Arends; Jo H M Berden; Stefan P Berger; Marc Bijl; Ruud G L de Sévaux; R H W M Derksen; Cecile Grootscholten; Alexandre E Voskuyl
Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis.
Annals of the rheumatic diseases 2012;71(6):966-73.
2012: Anne van Tellingen; Marc G Vervloet; A E Voskuyl; J H M Berden; S P Berger; M Bijl; R G L de Sévaux; R H W M Derksen
Dutch guidelines for diagnosis and therapy of proliferative lupus nephritis.
The Netherlands journal of medicine 2012;70(4):199-207.
2011: G M A Van O S; Ç Agar; P Åkesson; R H W M Derksen; H Herwald; J Arnoud Marquart; J C M Meijers; M Mörgelin; M V Seron; Rolf T Urbanus; P G D E Groot
Induction of anti-β2 -glycoprotein I autoantibodies in mice by protein H of Streptococcus pyogenes.
Journal of thrombosis and haemostasis : JTH 2011;9(12):2447-56.
2011: I Dienava-Verdoold; M G Boon-Spijker; Philip G de Groot; Herm-Jan Brinkman; Jan Voorberg; Koen Mertens; R H W M Derksen; Bas de Laat
Patient-derived monoclonal antibodies directed towards beta2 glycoprotein-1 display lupus anticoagulant activity.
Journal of thrombosis and haemostasis : JTH 2011;9(4):738-47.
2011: André Hartkamp; Rinie Geenen; Aike A Kruize; Ercolie R Bossema; G L R Godaert; Hendrika Bootsma; J W J Bijlsma; R H W M Derksen
Serum dehydroepiandrosterone sulphate levels and laboratory and clinical parameters indicating expression of disease are not associated with fatigue, well-being and functioning in patients with primary Sjögren's syndrome.
Clinical and experimental rheumatology 2011;29(2):318-21.
2011: Marlies C van der Goes; Ercolie R Bossema; André Hartkamp; G L R Godaert; Johannes W G Jacobs; Aike A Kruize; R H W M Derksen; Johannes W J Bijlsma; Rinie Geenen
Cortisol during the day in patients with systemic lupus erythematosus or primary Sjogren's syndrome.
The Journal of rheumatology 2011;38(2):285-8.
2011: Zurina Romay-Penabad; Renan Aguilar-Valenzuela; Rolf T Urbanus; R H W M Derksen; Maarten T T Pennings; Elizabeth Papalardo; Tuya Shilagard; Gracie Vargas; Yong Hwang; Philip G de Groot; Silvia S Pierangeli
Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome.
Blood 2011;117(4):1408-14.
2011: Bas de Laat; R H W M Derksen; G Reber; J Musial; J Swadzba; B Bozic; S Cucnik; V Regnault; R Forastiero; B J Woodhams; Ph G De Groot
An international multicentre-laboratory evaluation of a new assay to detect specifically lupus anticoagulants dependent on the presence of anti-beta2-glycoprotein autoantibodies.
Journal of thrombosis and haemostasis : JTH 2011;9(1):149-53.
2010: Henk A Martens; Sacha Gross; Gerrit van der Steege; Elisabeth Brouwer; Jo H M Berden; Ruud de Sevaux; R H W M Derksen; Alexandre E Voskuyl; Stefan P Berger; Gerjan J Navis; Cees G M Kallenberg; Marc Bijl
Lack of association of C-C chemokine receptor 5 Δ32 deletion status with rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, and disease severity.
The Journal of rheumatology 2010;37(11):2226-31.
2010: M L van Oers; Ercolie R Bossema; B J Thoolen; André Hartkamp; JC Dekkers; G L R Godaert; Aike A Kruize; R H W M Derksen; J W J Bijlsma; Rinie Geenen
Variability of fatigue during the day in patients with primary Sjögren's syndrome, systemic lupus erythematosus, and rheumatoid arthritis.
Clinical and experimental rheumatology 2010;28(5):715-21.
2010: Cetin Agar; Gwendolyn M A van Os; Matthias Mörgelin; Richard R Sprenger; J Arnoud Marquart; Rolf T Urbanus; R H W M Derksen; Joost C M Meijers; Philip G de Groot
Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome.
Blood 2010;116(8):1336-43.
2010: André Hartkamp; Rinie Geenen; G L R Godaert; Marc Bijl; J W J Bijlsma; R H W M Derksen
Effects of dehydroepiandrosterone on fatigue and well-being in women with quiescent systemic lupus erythematosus: a randomised controlled trial.
Annals of the rheumatic diseases 2010;69(6):1144-7.
2009: Bas de Laat; Philip G de Groot; R H W M Derksen; Rolf T Urbanus; Koen Mertens; Frits R Rosendaal; Carine J M Doggen
Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men.
Blood 2009;114(17):3656-61.
2008: Rolf T Urbanus; M T T Pennings; R H W M Derksen; Philip G de Groot
Platelet activation by dimeric beta2-glycoprotein I requires signaling via both glycoprotein Ibalpha and apolipoprotein E receptor 2'.
Journal of thrombosis and haemostasis : JTH 2008;6(8):1405-12.
2008: Idske C L Kremer Hovinga; Marije Koopmans; C Grootscholten; A M van der Wal; M Bijl; R H W M Derksen; A E Voskuyl; Emile de Heer; Jan A Bruijn; Jo H M Berden; Ingeborg M Bajema
Pregnancy, chimerism and lupus nephritis: a multi-centre study.
Lupus 2008;17(6):541-7.
2008: Rolf T Urbanus; R H W M Derksen; Philip G de Groot
Current insight into diagnostics and pathophysiology of the antiphospolipid syndrome.
Blood reviews 2008;22(2):93-105.
2008: Maria Nilsson; Sylwia Wasylik; Matthias Mörgelin; Anders I Olin; Joost C M Meijers; R H W M Derksen; Philip G de Groot; Heiko Herwald
The antibacterial activity of peptides derived from human beta-2 glycoprotein I is inhibited by protein H and M1 protein from Streptococcus pyogenes.
Molecular microbiology 2008;67(3):482-92.
2008: Cecile Grootscholten; Ingeborg M Bajema; Sandrine Florquin; Eric J Steenbergen; Carine J Peutz-Kootstra; roel goldschmeding; Marc Bijl; Chris Hagen; Hans C Van Houwelingen; R H W M Derksen; Jo H M Berden
Interobserver agreement of scoring of histopathological characteristics and classification of lupus nephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(1):223-30.
2008: André Hartkamp; Rinie Geenen; G L R Godaert; Hendrika Bootsma; Aike A Kruize; J W J Bijlsma; R H W M Derksen
Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial.
Annals of the rheumatic diseases 2008;67(1):91-7.
2008: R H W M Derksen; Ph G de Groot
The obstetric antiphospholipid syndrome.
Journal of reproductive immunology 2008;77(1):41-50.
2007: Janine J J Hulstein; Peter J Lenting; Bas de Laat; R H W M Derksen; Rob Fijnheer; Philip G de Groot
beta2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation.
Blood 2007;110(5):1483-91.
2007: Cecile Grootscholten; Frank J Snoek; Marc Bijl; Hans C Van Houwelingen; R H W M Derksen; Jo H M Berden
Health-related quality of life and treatment burden in patients with proliferative lupus nephritis treated with cyclophosphamide or azathioprine/ methylprednisolone in a randomized controlled trial.
The Journal of rheumatology 2007;34(8):1699-707.
2007: M T T Pennings; R H W M Derksen; Rolf T Urbanus; Winnie L Tekelenburg; W Hemrika; Philip G de Groot
Platelets express three different splice variants of ApoER2 that are all involved in signaling.
Journal of thrombosis and haemostasis : JTH 2007;5(7):1538-44.
2007: Peter E Westerweel; Remco K M A C Luijten; Imo E Hoefer; Hein A Koomans; R H W M Derksen; Marianne C Verhaar
Haematopoietic and endothelial progenitor cells are deficient in quiescent systemic lupus erythematosus.
Annals of the rheumatic diseases 2007;66(7):865-70.
2007: Peter E Westerweel; Remco K M A C Luyten; Hein A Koomans; R H W M Derksen; Marianne C Verhaar
Premature atherosclerotic cardiovascular disease in systemic lupus erythematosus.
Arthritis and rheumatism 2007;56(5):1384-96.
2007: Cecile Grootscholten; Jurgen Dieker; Fabian D McGrath; Anja Roos; R H W M Derksen; Johan Van der Vlag; Mohamed R Daha; Jo H M Berden
A prospective study of anti-chromatin and anti-C1q autoantibodies in patients with proliferative lupus nephritis treated with cyclophosphamide pulses or azathioprine/methylprednisolone.
Annals of the rheumatic diseases 2007;66(5):693-6.
2007: Cecile Grootscholten; Ingeborg M Bajema; Sandrine Florquin; Eric J Steenbergen; Carine J Peutz-Kootstra; roel goldschmeding; Marc Bijl; Chris Hagen; Hans C Van Houwelingen; R H W M Derksen; Jo H M Berden
Treatment with cyclophosphamide delays the progression of chronic lesions more effectively than does treatment with azathioprine plus methylprednisolone in patients with proliferative lupus nephritis.
Arthritis and rheumatism 2007;56(3):924-37.
2007: Bas de Laat; Xiao-Xuan Wu; Menno van Lummel; R H W M Derksen; Philip G de Groot; Jacob H Rand
Correlation between antiphospholipid antibodies that recognize domain I of beta2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5.
Blood 2007;109(4):1490-4.
2007: M T T Pennings; R H W M Derksen; Menno van Lummel; Jelle Adelmeijer; K VanHoorelbeke; Rolf T Urbanus; Ton Lisman; Philip G de Groot
Platelet adhesion to dimeric beta-glycoprotein I under conditions of flow is mediated by at least two receptors: glycoprotein Ibalpha and apolipoprotein E receptor 2'.
Journal of thrombosis and haemostasis : JTH 2007;5(2):369-77.
2006: Bas de Laat; R H W M Derksen; I J Mackie; M Roest; Selene Schoormans; B J Woodhams; Philip G de Groot; Waander L van Heerde
Annexin A5 polymorphism (-1C-->T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome.
Annals of the rheumatic diseases 2006;65(11):1468-72.
2006: A W A M van Rijthoven; J W J Bijlsma; M Canninga-van Dijk; R H W M Derksen; J A G van Roon
Onset of systemic lupus erythematosus after conversion of infliximab to adalimumab treatment in rheumatoid arthritis with a pre-existing anti-dsDNA antibody level.
Rheumatology (Oxford, England) 2006;45(10):1317-9.
2006: M T T Pennings; Menno van Lummel; R H W M Derksen; Rolf T Urbanus; Roland A Romijn; Peter J Lenting; Philip G de Groot
Interaction of beta2-glycoprotein I with members of the low density lipoprotein receptor family.
Journal of thrombosis and haemostasis : JTH 2006;4(8):1680-90.
2006: Cecile Grootscholten; Gerry Ligtenberg; Chris Hagen; A W L Van Den Wall Bake; J W de Glas-Vos; Marc Bijl; Karel J M Assmann; J A Bruijn; J J Weening; Hans C Van Houwelingen; R H W M Derksen; Jo H M Berden
Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial.
Kidney international 2006;70(4):732-42.
2006: Bas de Laat; R H W M Derksen; Philip G de Groot
High-avidity anti-beta glycoprotein I antibodies highly correlate with thrombosis in contrast to low-avidity anti-beta glycoprotein I antibodies.
Journal of thrombosis and haemostasis : JTH 2006;4(7):1619-21.
2006: P A J M Vos; bert bast; R H W M Derksen
Cost-effective detection of non-antidouble-stranded DNA antinuclear antibody specificities in daily clinical practice.
Rheumatology (Oxford, England) 2006;45(5):629-35.
2006: Bas de Laat; R H W M Derksen; Menno van Lummel; M T T Pennings; Philip G de Groot
Pathogenic anti-beta2-glycoprotein I antibodies recognize domain I of beta2-glycoprotein I only after a conformational change.
Blood 2006;107(5):1916-24.
2006: Spiros Miyakis; M D Lockshin; T Atsumi; D W Branch; Robin Brey; Ricard Cervera; R H W M Derksen; P G DE Groot; T Koike; P L Meroni; G Reber; Y Shoenfeld; A Tincani; P G Vlachoyiannopoulos; Steven A Krilis
International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS).
Journal of thrombosis and haemostasis : JTH 2006;4(2):295-306.
2006: Philip G de Groot; R H W M Derksen
The importance of measuring anticardiolipin antibodies.
Journal of thrombosis and haemostasis : JTH 2006;4(1):41-3.
2005: Johanna E Vriezekolk; Rinie Geenen; André Hartkamp; G L R Godaert; Hendrika Bootsma; Aike A Kruize; J W J Bijlsma; R H W M Derksen
Psychological and somatic predictors of perceived and measured ocular dryness of patients with primary Sjögren's syndrome.
The Journal of rheumatology 2005;32(12):2351-5.
2005: Menno van Lummel; M T T Pennings; R H W M Derksen; Rolf T Urbanus; Bianca C H Lutters; Niels Kaldenhoven; Philip G de Groot
The binding site in {beta}2-glycoprotein I for ApoER2' on platelets is located in domain V.
The Journal of biological chemistry 2005;280(44):36729-36.
2005: Philip G de Groot; Bianca C H Lutters; R H W M Derksen; Ton Lisman; Joost C M Meijers; Frits R Rosendaal
Lupus anticoagulants and the risk of a first episode of deep venous thrombosis.
Journal of thrombosis and haemostasis : JTH 2005;3(9):1993-7.
2005: P A J M Vos; J W J Bijlsma; R H W M Derksen
[Polymyalgia rheumatica and temporal arteritis].
Nederlands tijdschrift voor geneeskunde 2005;149(35):1932-7.
2005: Philip G de Groot; R H W M Derksen
Pathophysiology of the antiphospholipid syndrome.
Journal of thrombosis and haemostasis : JTH 2005;3(8):1854-60.
2005: Philip G de Groot; R H W M Derksen
The antiphospholipid syndrome: clinical characteristics, laboratory features and pathogenesis.
Current opinion in infectious diseases 2005;18(3):205-10.
2005: Bas de Laat; R H W M Derksen; Rolf T Urbanus; Philip G de Groot
IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis.
Blood 2005;105(4):1540-5.
2004: H Bas de Laat; R H W M Derksen; Rolf T Urbanus; Mark Roest; Philip G de Groot
beta2-glycoprotein I-dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome.
Blood 2004;104(12):3598-602.
2004: André Hartkamp; Rinie Geenen; G L R Godaert; Marc Bijl; J W J Bijlsma; R H W M Derksen
The effect of dehydroepiandrosterone on lumbar spine bone mineral density in patients with quiescent systemic lupus erythematosus.
Arthritis and rheumatism 2004;50(11):3591-5.
2004: Rolf T Urbanus; H B de Laat; Philip G de Groot; R H W M Derksen
Prolonged bleeding time and lupus anticoagulant: a second paradox in the antiphospholipid syndrome.
Arthritis and rheumatism 2004;50(11):3605-9.
2004: André Hartkamp; Rinie Geenen; Marc Bijl; Aike A Kruize; G L R Godaert; R H W M Derksen
Serum cytokine levels related to multiple dimensions of fatigue in patients with primary Sjogren's syndrome.
Annals of the rheumatic diseases 2004;63(10):1335-7.
2004: R H W M Derksen; Philip G de Groot
Clinical consequences of antiphospholipid antibodies.
The Netherlands journal of medicine 2004;62(8):273-8.
2004: Philip G de Groot; R H W M Derksen
Pathophysiology of antiphospholipid antibodies.
The Netherlands journal of medicine 2004;62(8):267-72.
2004: H Bas de Laat; R H W M Derksen; Philip G de Groot
beta2-glycoprotein I, the playmaker of the antiphospholipid syndrome.
Clinical immunology (Orlando, Fla.) 2004;112(2):161-8.
2004: Philip G de Groot; R H W M Derksen
Antiphospholipid antibodies: update on detection, pathophysiology, and treatment.
Current opinion in hematology 2004;11(3):165-9.
2004: R H W M Derksen; Munther A Khamashta; D Ware Branch
Management of the obstetric antiphospholipid syndrome.
Arthritis and rheumatism 2004;50(4):1028-39.
2004: R H W M Derksen; Philip G de Groot
Tests for lupus anticoagulant revisited.
Thrombosis research 2004;114(5-6):521-6.
2004: Philip G de Groot; Menno van Lummel; M T T Pennings; Rolf T Urbanus; H Bas de Laat; Peter J Lenting; R H W M Derksen
Beta2-glycoprotein I and LDL-receptor family members.
Thrombosis research 2004;114(5-6):455-9.
2003: Bianca C H Lutters; R H W M Derksen; Winnie L Tekelenburg; Peter J Lenting; Jef Arnout; Philip G de Groot
Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'.
The Journal of biological chemistry 2003;278(36):33831-8.
2003: Cecile Grootscholten; Gerry Ligtenberg; R H W M Derksen; K M G Schreurs; J W de Glas-Vos; Chris Hagen; A W L Van Den Wall Bake; Tom W J Huizinga; F H J van den Hoogen; Marc Bijl; J C van Houwelingen; Frank J Snoek; Jo H M Berden
Health-related quality of life in patients with systemic lupus erythematosus: development and validation of a lupus specific symptom checklist.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2003;12(6):635-44.
2003: R H W M Derksen; Philip G de Groot; L Jaap Kappelle
Low dose aspirin after ischemic stroke associated with antiphospholipid syndrome.
Neurology 2003;61(1):111-4.
2003: Cecile Grootscholten; Mieke C J van Bruggen; Johan W van der Pijl; Elke M G J de Jong; Gerry Ligtenberg; R H W M Derksen; Jo H M Berden
Deposition of nucleosomal antigens (histones and DNA) in the epidermal basement membrane in human lupus nephritis.
Arthritis and rheumatism 2003;48(5):1355-62.
2003: Marleen J A Simmelink; R H W M Derksen; J Arnout; Philip G de Groot
A simple method to discriminate between beta2-glycoprotein I- and prothrombin-dependent lupus anticoagulants.
Journal of thrombosis and haemostasis : JTH 2003;1(4):740-7.
2003: Marleen J A Simmelink; Philip G de Groot; R H W M Derksen
A study on associations between antiprothrombin antibodies, antiplasminogen antibodies and thrombosis.
Journal of thrombosis and haemostasis : JTH 2003;1(4):735-9.
2003: Waander L van Heerde; Chris P M Reutelingsperger; C Maassen; Petra Lux; R H W M Derksen; Philip G de Groot
The presence of antiphospholipid antibodies is not related to increased levels of annexin A5 in plasma.
Journal of thrombosis and haemostasis : JTH 2003;1(3):532-6.
2003: Robin Brey; J Chapman; Steven R Levine; Guillermo Ruiz-Irastorza; R H W M Derksen; M Khamashta; Y Shoenfeld
Stroke and the antiphospholipid syndrome: consensus meeting Taormina 2002.
Lupus 2003;12(7):508-13.
2003: Pier Luigi Meroni; Marco Moia; R H W M Derksen; Angela Tincani; john mcintyre; J M M C Arnout; Takao Koike; J-C Piette; Munther A Khamashta; Y Shoenfeld
Venous thromboembolism in the antiphospholipid syndrome: management guidelines for secondary prophylaxis.
Lupus 2003;12(7):504-7.
2003: Dudy G Kuiper-Geertsma; R H W M Derksen
Newer drugs for the treatment of lupus nephritis.
Drugs 2003;63(2):167-80.
2002: R H W M Derksen; bert bast; T Strooisma; J W G Jacobs
A comparison between the Farr radioimmunoassay and a new automated fluorescence immunoassay for the detection of antibodies against double stranded DNA in serum.
Annals of the rheumatic diseases 2002;61(12):1099-102.
2002: Marleen J A Simmelink; Philip G de Groot; R H W M Derksen; José A Fernandez; John H Griffin
Oral anticoagulation reduces activated protein C less than protein C and other vitamin K-dependent clotting factors.
Blood 2002;100(12):4232-3.
2002: Bianca C H Lutters; Philip G de Groot; R H W M Derksen
beta 2 Glycoprotein I--a key player in the antiphospholipid syndrome.
The Israel Medical Association journal : IMAJ 2002;4(11 Suppl):958-62.
2002: R H W M Derksen; J W J Bijlsma
[The treatment of chronic inflammatory diseases with monoclonal antibodies against tumor necrosis factor: side effects, contraindications and precautions].
Nederlands tijdschrift voor geneeskunde 2002;146(25):1165-8.
2002: G L R Godaert; André Hartkamp; Rinie Geenen; A Garssen; Aike A Kruize; J W J Bijlsma; R H W M Derksen
Fatigue in daily life in patients with primary Sjögren's syndrome and systemic lupus erythematosus.
Annals of the New York Academy of Sciences 2002;966():320-6.
2002: Marleen J A Simmelink; José A Fernández; R H W M Derksen; John H Griffin; Philip G de Groot
Low levels of activated protein C in patients with systemic lupus erythematosus do not relate to lupus anticoagulants but to low levels of factor II.
British journal of haematology 2002;117(3):676-84.
2002: Ricard Cervera; Jean-Charles Piette; Josep Font; Munther A Khamashta; Yehuda Shoenfeld; María Teresa Camps; Soren Jacobsen; Gabriella Lakos; Angela Tincani; Irene Kontopoulou-Griva; Mauro Galeazzi; Pier Luigi Meroni; R H W M Derksen; Philip G de Groot; Erika Gromnica-Ihle; Marta Baleva; Marta Mosca; Stefano Bombardieri; Frédéric A Houssiau; Jean-Christophe Gris; Isabelle Quéré; Eric Hachulla; carlos vasconcelos; Beate Roch; Antonio Fernández-Nebro; Marie-Claire Boffa; G R V Hughes; Miguel Ingelmo
Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients.
Arthritis and rheumatism 2002;46(4):1019-27.
2002: Marc Bijl; Hilde M Dijstelbloem; WW Oost; Hendrika Bootsma; R H W M Derksen; J Aten; Pieter C Limburg; Cees G M Kallenberg
IgG subclass distribution of autoantibodies differs between renal and extra-renal relapses in patients with systemic lupus erythematosus.
Rheumatology (Oxford, England) 2002;41(1):62-7.
2001: C J M Frijns; R H W M Derksen; Philip G de Groot; Ale Algra; Rob Fijnheer
Lupus anticoagulant and history of thrombosis are not associated with persistent endothelial cell activation in systemic lupus erythematosus.
Clinical and experimental immunology 2001;125(1):149-54.
2001: Marleen J A Simmelink; DA Horbach; R H W M Derksen; Joost C M Meijers; Edouard M Bevers; G M Willems; Philip G de Groot
Complexes of anti-prothrombin antibodies and prothrombin cause lupus anticoagulant activity by competing with the binding of clotting factors for catalytic phospholipid surfaces.
British journal of haematology 2001;113(3):621-9.
2001: Bianca C H Lutters; Joost C M Meijers; R H W M Derksen; Jef Arnout; Philip G de Groot
Dimers of beta 2-glycoprotein I mimic the in vitro effects of beta 2-glycoprotein I-anti-beta 2-glycoprotein I antibody complexes.
The Journal of biological chemistry 2001;276(5):3060-7.
2001: R H W M Derksen; Philip G de Groot; H Karel Nieuwenhuis; G C M L Christiaens
How to treat women with antiphospholipid antibodies in pregnancy?
Annals of the rheumatic diseases 2001;60(1):1-3.
2000: Philip G de Groot; Barend Bouma; Bianca C H Lutters; R H W M Derksen
Lupus anticoagulant in cardiovascular diseases: the role of beta2-glycoprotein I.
Annals of medicine 2000;32 Suppl 1():32-6.
2000: Hilde M Dijstelbloem; Marc Bijl; R Fijnheer; RH Scheepers; WW Oost; Marc D Jansen; Wim J Sluiter; Pieter C Limburg; R H W M Derksen; Jan G J van de Winkel; Cees G M Kallenberg
Fcgamma receptor polymorphisms in systemic lupus erythematosus: association with disease and in vivo clearance of immune complexes.
Arthritis and rheumatism 2000;43(12):2793-800.
2000: R H W M Derksen; P G de Groot
Do we know which patients with the antiphospholipid syndrome should receive long-term high dose anti-coagulation?
Journal of autoimmunity 2000;15(2):255-9.
2000: P G de Groot G; Barend Bouma; Bianca C H Lutters; Marleen J A Simmelink; R H W M Derksen; Piet Gros
Structure-function studies on beta 2-glycoprotein I.
Journal of autoimmunity 2000;15(2):87-9.
1999: Barend Bouma; Philip G de Groot; Jean van den Elsen; Raimond B G Ravelli; Arie Schouten; Marleen J A Simmelink; R H W M Derksen; Jan Kroon; Piet Gros
Adhesion mechanism of human beta(2)-glycoprotein I to phospholipids based on its crystal structure.
The EMBO journal 1999;18(19):5166-74.
1999: DA Horbach; Erica van Oort; Ton Lisman; Joost C M Meijers; R H W M Derksen; Philip G de Groot
Beta2-glycoprotein I is proteolytically cleaved in vivo upon activation of fibrinolysis.
Thrombosis and haemostasis 1999;81(1):87-95.
1998: DA Horbach; Erica van Oort; M J Tempelman; R H W M Derksen; Philip G de Groot
The prevalence of a non-phospholipid-binding form of beta2-glycoprotein I in human plasma--consequences for the development of anti-beta2-glycoprotein I antibodies.
Thrombosis and haemostasis 1998;80(5):791-7.
1998: RM van Vugt; R H W M Derksen; L Kater; J W J Bijlsma
Deforming arthropathy or lupus and rhupus hands in systemic lupus erythematosus.
Annals of the rheumatic diseases 1998;57(9):540-4.
1998: Rob Fijnheer; M Roest; F J Haas; P G De Groot; R H W M Derksen
Homocysteine, methylenetetrahydrofolate reductase polymorphism, antiphospholipid antibodies, and thromboembolic events in systemic lupus erythematosus: a retrospective cohort study.
The Journal of rheumatology 1998;25(9):1737-42.
1998: R C Donders; L Jaap Kappelle; R H W M Derksen; Ale Algra; DA Horbach; Philip G de Groot; Jan van Gijn
Transient monocular blindness and antiphospholipid antibodies in systemic lupus erythematosus.
Neurology 1998;51(2):535-40.
1998: R H W M Derksen
Dehydroepiandrosterone (DHEA) and systemic lupus erythematosus.
Seminars in arthritis and rheumatism 1998;27(6):335-47.
1998: DA Horbach; Erica van Oort; R H W M Derksen; Philip G de Groot
The contribution of anti-prothrombin-antibodies to lupus anticoagulant activity--discrimination between functional and non-functional anti-prothrombin-antibodies.
Thrombosis and haemostasis 1998;79(4):790-5.
1998: Philip G de Groot; DA Horbach; Marleen J A Simmelink; Erica van Oort; R H W M Derksen
Anti-prothrombin antibodies and their relation with thrombosis and lupus anticoagulant.
Lupus 1998;7 Suppl 2():S32-6.
1997: R H W M Derksen; G C M L Christiaens; L Kater
[Immunology in medical practice. II. Antiphospholipid antibodies in pregnancy].
Nederlands tijdschrift voor geneeskunde 1997;141(37):1769-73.
1997: C G Kallenberg; Hendrika Bootsma; P E Spronk; E J ter Borg; R H W M Derksen; L Kater
Laboratory tests as predictors of flares in systemic lupus erythematosus: comment on the article by Esdaile et al.
Arthritis and rheumatism 1997;40(2):393-4.
1996: DA Horbach; Erica van Oort; Rogier Donders; R H W M Derksen; Philip G de Groot
Lupus anticoagulant is the strongest risk factor for both venous and arterial thrombosis in patients with systemic lupus erythematosus. Comparison between different assays for the detection of antiphospholipid antibodies.
Thrombosis and haemostasis 1996;76(6):916-24.
1996: Rob Fijnheer; DA Horbach; Rogier Donders; H Vilé; E von Oort; H Karel Nieuwenhuis; F H Gmelig-Meijling; Philip G de Groot; R H W M Derksen
Factor V Leiden, antiphospholipid antibodies and thrombosis in systemic lupus erythematosus.
Thrombosis and haemostasis 1996;76(4):514-7.
1996: Philip G de Groot; DA Horbach; R H W M Derksen
Protein C and other cofactors involved in the binding of antiphospholipid antibodies: relation to the pathogenesis of thrombosis.
Lupus 1996;5(5):488-93.
1996: DA Horbach; R H W M Derksen; Philip G de Groot
The presence of anti-beta 2-glycoprotein I and anti-prothrombin antibodies and their correlations with venous and arterial thrombosis.
Annales de médecine interne 1996;147 Suppl 1():42-3.
1996: R H W M Derksen; F H Gmelig-Meijling; Philip G de Groot
Primary antiphospholipid syndrome evolving into systemic lupus erythematosus.
Lupus 1996;5(1):77-80.
1995: A J Duits; Hendrika Bootsma; R H W M Derksen; P E Spronk; L Kater; Cees G M Kallenberg; PJ Capel; N A Westerdaal; G T Spierenburg; F H Gmelig-Meyling
Skewed distribution of IgG Fc receptor IIa (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients.
Arthritis and rheumatism 1995;38(12):1832-6.
1995: Hendrika Bootsma; P Spronk; R H W M Derksen; G de Boer; H Wolters-Dicke; J Hermans; Pieter C Limburg; F Gmelig-Meyling; L Kater; Cees G M Kallenberg
Prevention of relapses in systemic lupus erythematosus.
Lancet 1995;345(8965):1595-9.
1994: Philip G de Groot; R H W M Derksen
Protein C pathway, antiphospholipid antibodies and thrombosis.
Lupus 1994;3(4):229-33.
1993: J D Oosting; K T Preissner; R H W M Derksen; Philip G de Groot
Autoantibodies directed against the epidermal growth factor-like domains of thrombomodulin inhibit protein C activation in vitro.
British journal of haematology 1993;85(4):761-8.
1993: R H W M Derksen; Philip G de Groot; L Kater; H K Nieuwenhuis
Patients with antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment.
Annals of the rheumatic diseases 1993;52(9):689-92.
1993: J D Oosting; R H W M Derksen; I W Bobbink; T M Hackeng; Bonno N Bouma; Philip G de Groot
Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism?
Blood 1993;81(10):2618-25.
1992: J D Oosting; R H W M Derksen; L Blokzijl; Jan J Sixma; Philip G de Groot
Antiphospholipid antibody positive sera enhance endothelial cell procoagulant activity--studies in a thrombosis model.
Thrombosis and haemostasis 1992;68(3):278-84.
1992: R H W M Derksen; J F Meilof
Anti-Ro/SS-A and anti-La/SS-B autoantibody levels in relation to systemic lupus erythematosus disease activity and congenital heart block. A longitudinal study comprising two consecutive pregnancies in a patient with systemic lupus erythematosus.
Arthritis and rheumatism 1992;35(8):953-9.
1992: H J Out; Hein W Bruinse; G C Christiaens; M van Vliet; Philip G de Groot; H K Nieuwenhuis; R H W M Derksen
A prospective, controlled multicenter study on the obstetric risks of pregnant women with antiphospholipid antibodies.
American journal of obstetrics and gynecology 1992;167(1):26-32.
1992: J D Oosting; R H W M Derksen; H T Entjes; Bonno N Bouma; Philip G de Groot
Lupus anticoagulant activity is frequently dependent on the presence of beta 2-glycoprotein I.
Thrombosis and haemostasis 1992;67(5):499-502.
1992: R H W M Derksen; H J Out; L Blokzijl; Philip G de Groot
Detection of the lupus anticoagulant in pregnancy.
Clinical and experimental rheumatology 1992;10(3):323-4.
1992: H J Out; M van Vliet; Philip G de Groot; R H W M Derksen
Prospective study of fluctuations of lupus anticoagulant activity and anticardiolipin antibody titre in patients with systemic lupus erythematosus.
Annals of the rheumatic diseases 1992;51(3):353-7.
1991: J D Oosting; R H W M Derksen; T M Hackeng; M van Vliet; K T Preissner; Bonno N Bouma; Philip G de Groot
In vitro studies of antiphospholipid antibodies and its cofactor, beta 2-glycoprotein I, show negligible effects on endothelial cell mediated protein C activation.
Thrombosis and haemostasis 1991;66(6):666-71.
1991: H J Out; C D Kooijman; Hein W Bruinse; R H W M Derksen
Histopathological findings in placentae from patients with intra-uterine fetal death and anti-phospholipid antibodies.
European journal of obstetrics, gynecology, and reproductive biology 1991;41(3):179-86.
1991: H J Out; Hein W Bruinse; G C Christiaens; M van Vliet; J F Meilof; Philip G de Groot; RJ Smeenk; R H W M Derksen
Prevalence of antiphospholipid antibodies in patients with fetal loss.
Annals of the rheumatic diseases 1991;50(8):553-7.
1991: H J Out; Hein W Bruinse; R H W M Derksen
Anti-phospholipid antibodies and pregnancy loss.
Human reproduction (Oxford, England) 1991;6(6):889-97.
1991: H J Out; Philip G de Groot; M van Vliet; Gijsbert C De Gast; H K Nieuwenhuis; R H W M Derksen
Antibodies to platelets in patients with anti-phospholipid antibodies.
Blood 1991;77(12):2655-9.
1991: L Kater; R H W M Derksen; R J Hené
Treatment of systemic lupus erythematosus: which options do we have for therapy regimens?
Rheumatology international 1991;11(3):137-40.
1991: R H W M Derksen
Systemic lupus erythematosus and pregnancy.
Rheumatology international 1991;11(3):121-5.
1990: P Hasselaar; R H W M Derksen; L Blokzijl; Philip G de Groot
Crossreactivity of antibodies directed against cardiolipin, DNA, endothelial cells and blood platelets.
Thrombosis and haemostasis 1990;63(2):169-73.
1990: H J Out; L Kater; R H W M Derksen
Antiphospholipid antibodies: risk factors or only markers for thrombosis, fetal loss and thrombocytopenia?
The Netherlands journal of medicine 1990;36(3-4):177-81.
1990: R H W M Derksen; P Hasselaar; J D Oosting; Philip G de Groot
The antiphospholipid antibody dilemma.
Clinical rheumatology 1990;9(1 Suppl 1):39-44.
1990: P Hasselaar; D A Triplett; Amanda C Larue; R H W M Derksen; L Blokzijl; Philip G de Groot; D R Wagenknecht; john mcintyre
Heat treatment of serum and plasma induces false positive results in the antiphospholipid antibody ELISA.
The Journal of rheumatology 1990;17(2):186-91.
1989: H J Out; Philip G de Groot; P Hasselaar; M dan Vliet; R H W M Derksen
Fluctuations of anticardiolipin antibody levels in patients with systemic lupus erythematosus: a prospective study.
Annals of the rheumatic diseases 1989;48(12):1023-8.
1989: P Hasselaar; R H W M Derksen; L Blokzijl; Martin Hessing; H Karel Nieuwenhuis; Bonno N Bouma; Philip G de Groot
Risk factors for thrombosis in lupus patients.
Annals of the rheumatic diseases 1989;48(11):933-40.
1989: P Hasselaar; R H W M Derksen; J D Oosting; L Blokzijl; Philip G de Groot
Synergistic effect of low doses of tumor necrosis factor and sera from patients with systemic lupus erythematosus on the expression of procoagulant activity by cultured endothelial cells.
Thrombosis and haemostasis 1989;62(2):654-60.
1989: H J Out; R H W M Derksen; G C Christiaens
Systemic lupus erythematosus and pregnancy.
Obstetrical & gynecological survey 1989;44(8):585-91.
1989: J J Cornelissen; W Haanstra; H J Haarman; R H W M Derksen
Plasma exchange in rhabdomyolysis.
Intensive care medicine 1989;15(8):528-9.
1988: R H W M Derksen; P Hasselaar; L Blokzijl; F H Gmelig Meyling; Philip G de Groot
Coagulation screen is more specific than the anticardiolipin antibody ELISA in defining a thrombotic subset of lupus patients.
Annals of the rheumatic diseases 1988;47(5):364-71.
1988: P Hasselaar; R H W M Derksen; L Blokzijl; Philip G de Groot
Thrombosis associated with antiphospholipid antibodies cannot be explained by effects on endothelial and platelet prostanoid synthesis.
Thrombosis and haemostasis 1988;59(1):80-5.
1988: R H W M Derksen; B P Overbeek; P H Poeschmann
Serious bacterial cellulitis of the periorbital area in two patients with systemic lupus erythematosus.
The Journal of rheumatology 1988;15(5):840-4.
1987: R H W M Derksen; P Hasselaar; L Blokzijl; Philip G de Groot
Lack of efficacy of plasma-exchange in removing antiphospholipid antibodies.
Lancet 1987;2(8552):222.