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Peter Dervan

Research Profile

Chemicals & Drugs

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Phenomena

Genes & Molecular Sequences

Molecular Structure

Physiology

Transcription, Genetic

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Publications

TOP 3
Nicholas G Nickols; Jevgenij A Raskatov; Jerzy O Szablowski; Amanda E Hargrove; Benjamin C Li; Peter B Dervan
Activity of a py-im polyamide targeted to the estrogen response element.
Fei Yang; Benjamin C Li; Georgi K Marinov; Nicholas G Nickols; Jonathan W Said; Peter B Dervan
Antitumor activity of a pyrrole-imidazole polyamide.
Benjamin C Li; David C Montgomery; James W Puckett; Peter B Dervan
Synthesis of cyclic Py-Im polyamide libraries.

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All Publications

2013: Nicholas G Nickols; Jevgenij A Raskatov; Jerzy O Szablowski; Amanda E Hargrove; Benjamin C Li; Peter B Dervan
Activity of a py-im polyamide targeted to the estrogen response element.
Molecular cancer therapeutics 2013;12(5):675-84.
2013: Fei Yang; Benjamin C Li; Georgi K Marinov; Nicholas G Nickols; Jonathan W Said; Peter B Dervan
Antitumor activity of a pyrrole-imidazole polyamide.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1863-8.
2013: Benjamin C Li; David C Montgomery; James W Puckett; Peter B Dervan
Synthesis of cyclic Py-Im polyamide libraries.
The Journal of organic chemistry 2013;78(1):124-33.
2013: David M Chenoweth; Jordan L Meier; Peter B Dervan
Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.
Angewandte Chemie (International ed. in English) 2013;52(1):415-8.
2012: Jordan L Meier; David J Segal; Abigail S Yu; Ian F Korf; Peter B Dervan
Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing.
Journal of the American Chemical Society 2012;134(42):17814-22.
2012: Jevgenij A Raskatov; Barbara Wold; Amanda E Hargrove; Georgi K Marinov; Nicholas G Nickols; Peter B Dervan
Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(40):16041-5.
2012: Jintang Du; Erica Campau; Peter B Dervan; Sherman Ku; James W Puckett; Elisabetta Soragni; Joel M Gottesfeld
Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells.
The Journal of biological chemistry 2012;287(35):29861-72.
2012: C James Chou; Elisabetta Soragni; Paramjit S Arora; Peter B Dervan; C James Chou; Joel M Gottesfeld
Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells.
Bioorganic & medicinal chemistry letters 2012;22(12):4068-71.
2012: Amanda E Hargrove; Jordan L Meier; David C Montgomery; Jevgenij A Raskatov; Peter B Dervan
Characterization and solubilization of pyrrole-imidazole polyamide aggregates.
Journal of medicinal chemistry 2012;55(11):5425-32.
2012: James W Puckett; Joshua T Green; Peter B Dervan
Microwave assisted synthesis of Py-Im polyamides.
Organic letters 2012;14(11):2774-7.
2012: Jevgenij A Raskatov; Alex Y So; Amanda E Hargrove; Peter B Dervan
Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.
Journal of the American Chemical Society 2012;134(18):7995-9.
2012: Jordan L Meier; David C Montgomery; Peter B Dervan
Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns.
Nucleic acids research 2012;40(5):2345-56.
2012: Jevgenij A Raskatov; Fei Yang; Jordan L Meier; James W Puckett; Parameswaran Ramakrishnan; Peter B Dervan
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(4):1023-8.
2011: Yi Zhang; Xiaohui Cui; Peter B Dervan; Daniel A Harki; Kimberly Lezon-Geyda; Katy A Muzikar; Géraldine Sicot; Daniel A Stolper; Marion Vogel; John Wheeler; Charles A Wuertzer; Archibald S Perkins
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide.
Biochemistry 2011;50(48):10431-41.
2011: Katy A Muzikar; Jevgenij A Raskatov; Daniel A Gubler; Jordan L Meier; Peter B Dervan
Expanding the repertoire of natural product-inspired ring pairs for molecular recognition of DNA.
Organic letters 2011;13(20):5612-5.
2010: David M Chenoweth; Peter B Dervan
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding.
Journal of the American Chemical Society 2010;132(41):14521-9.
2009: Claire S Jacobs; Peter B Dervan
Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture.
Journal of medicinal chemistry 2009;52(23):7380-8.
2009: Katy A Muzikar; Nicholas G Nickols; Peter B Dervan
Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(39):16598-603.
2009: David M Chenoweth; Daniel A Harki; Peter B Dervan
Oligomerization route to Py-Im polyamide macrocycles.
Organic letters 2009;11(16):3590-3.
2009: David M Chenoweth; Peter B Dervan
Allosteric modulation of DNA by small molecules.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13175-9.
2009: Michelle E Farkas; Benjamin C Li; Christian Dose; Peter B Dervan
DNA sequence selectivity of hairpin polyamide turn units.
Bioorganic & medicinal chemistry letters 2009;19(14):3919-23.
2009: David M Chenoweth; Daniel A Harki; Peter B Dervan
Solution-phase synthesis of pyrrole-imidazole polyamides.
Journal of the American Chemical Society 2009;131(20):7175-81.
2009: David M Chenoweth; Daniel A Harki; John W Phillips; Christian Dose; Peter B Dervan
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.
Journal of the American Chemical Society 2009;131(20):7182-8.
2008: Carey F Hsu; Peter B Dervan
Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells.
Bioorganic & medicinal chemistry letters 2008;18(22):5851-5.
2008: Daniel A Harki; Nagichettiar Satyamurthy; David B Stout; Michael E Phelps; Peter B Dervan
In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):13039-44.
2008: Christian Dose; Michelle E Farkas; David M Chenoweth; Peter B Dervan
Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit.
Journal of the American Chemical Society 2008;130(21):6859-66.
2008: Rocco Moretti; Leslie Donato; Mary L Brezinski; Ryan L Stafford; Helena Hoff; Jon S Thorson; Peter B Dervan; Aseem Z Ansari
Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly.
ACS chemical biology 2008;3(4):220-9.
2008: C James Chou; Michelle E Farkas; Sherry M Tsai; David Alvarez; Peter B Dervan; Joel M Gottesfeld
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.
Molecular cancer therapeutics 2008;7(4):769-78.
2008: Justin D Cohen; John P Sadowski; Peter B Dervan
Programming multiple protein patterns on a single DNA nanostructure.
Journal of the American Chemical Society 2008;130(2):402-3.
2007: Michelle E Farkas; Sherry M Tsai; Peter B Dervan
Alpha-diaminobutyric acid-linked hairpin polyamides.
Bioorganic & medicinal chemistry 2007;15(22):6927-36.
2007: Ryan L Stafford; Peter B Dervan
The reach of linear protein-DNA dimerizers.
Journal of the American Chemical Society 2007;129(45):14026-33.
2007: James W Puckett; Katy A Muzikar; Josh Tietjen; Christopher L Warren; Aseem Z Ansari; Peter B Dervan
Quantitative microarray profiling of DNA-binding molecules.
Journal of the American Chemical Society 2007;129(40):12310-9.
2007: Nicholas G Nickols; Claire S Jacobs; Michelle E Farkas; Peter B Dervan
Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface.
ACS chemical biology 2007;2(8):561-71.
2007: Nicholas G Nickols; Peter B Dervan
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10418-23.
2007: Ryan L Stafford; Hans-Dieter Arndt; Mary L Brezinski; Aseem Z Ansari; Peter B Dervan
Minimization of a protein-DNA dimerizer.
Journal of the American Chemical Society 2007;129(9):2660-8.
2007: David M Chenoweth; Anne Viger; Peter B Dervan
Fluorescent sequence-specific dsDNA binding oligomers.
Journal of the American Chemical Society 2007;129(8):2216-7.
2007: David M Chenoweth; Julie A Poposki; Michael A Marques; Peter B Dervan
Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition.
Bioorganic & medicinal chemistry 2007;15(2):759-70.
2007: Christian Dose; Dominik Ho; Hermann E Gaub; Peter B Dervan; Christian H Albrecht
Recognition of "mirror-image" DNA by small molecules.
Angewandte Chemie (International ed. in English) 2007;46(44):8384-7.
2007: Justin D Cohen; John P Sadowski; Peter B Dervan
Addressing single molecules on DNA nanostructures.
Angewandte Chemie (International ed. in English) 2007;46(42):7956-9.
2007: Nicholas G Nickols; Claire S Jacobs; Michelle E Farkas; Peter B Dervan
Improved nuclear localization of DNA-binding polyamides.
Nucleic acids research 2007;35(2):363-70.
2007: Sherry M Tsai; Michelle E Farkas; C James Chou; Joel M Gottesfeld; Peter B Dervan
Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates.
Nucleic acids research 2007;35(1):307-16.
2006: Anne Viger; Peter B Dervan
Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site.
Bioorganic & medicinal chemistry 2006;14(24):8539-49.
2006: Ryan Burnett; Christian Melander; James W Puckett; Leslie S Son; Robert D Wells; Peter B Dervan; Joel M Gottesfeld
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11497-502.
2006: Raymond M Doss; Michael A Marques; Shane Foister; David M Chenoweth; Peter B Dervan
Programmable oligomers for minor groove DNA recognition.
Journal of the American Chemical Society 2006;128(28):9074-9.
2006: David Alvarez; C James Chou; Lucia Latella; Zeitlin Samantha; Sherman Ku; Pier Lorenzo Puri; Peter B Dervan; Joel M Gottesfeld
A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate.
Cell cycle (Georgetown, Tex.) 2006;5(14):1537-48.
2006: Christopher L Warren; Natasha C S Kratochvil; Karl E Hauschild; Shane Foister; Mary L Brezinski; Peter B Dervan; George N Phillips; Aseem Z Ansari
Defining the sequence-recognition profile of DNA-binding molecules.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):867-72.
2005: Eric J Fechter; Bogdan Olenyuk; Peter B Dervan
Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates.
Journal of the American Chemical Society 2005;127(47):16685-91.
2005: Peter B Dervan; Raymond M Doss; Michael A Marques
Programmable DNA binding oligomers for control of transcription.
Current medicinal chemistry. Anti-cancer agents 2005;5(4):373-87.
2005: Karl E Hauschild; Renee E Metzler; Hans-Dieter Arndt; Rocco Moretti; Marni Raffaelle; Peter B Dervan; Aseem Z Ansari
Temperature-sensitive protein-DNA dimerizers.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):5008-13.
2005: Micah D Gearhart; Liliane A Dickinson; Jennifer Ehley; Christian Melander; Peter B Dervan; Peter Wright; Joel M Gottesfeld
Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides.
Biochemistry 2005;44(11):4196-203.
2005: Brian J Philips; Aileen Y Chang; Peter B Dervan; Terry Beerman
DNA damage effects of a polyamide-CBI conjugate in SV40 virions.
Molecular pharmacology 2005;67(3):877-82.
2005: Rajeswari S Edayathumangalam; Philipp Weyermann; Peter B Dervan; Joel M Gottesfeld; Karolin Luger
Nucleosomes in solution exist as a mixture of twist-defect states.
Journal of molecular biology 2005;345(1):103-14.
2004: Bogdan Olenyuk; Guo-Jun Zhang; Jeffery M Klco; Nicholas G Nickols; William G Kaelin; Peter B Dervan
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(48):16768-73.
2004: Liliane A Dickinson; Ryan Burnett; Christian Melander; Benjamin S Edelson; Paramjit S Arora; Peter B Dervan; Joel M Gottesfeld
Arresting cancer proliferation by small-molecule gene regulation.
Chemistry & biology 2004;11(11):1583-94.
2004: Loyda Ylisastigui; Jason J Coull; Victor C Rucker; Christian Melander; Ronald J Bosch; Scott J Brodie; Lawrence Corey; Donald L Sodora; Peter B Dervan; David M Margolis
Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors.
The Journal of infectious diseases 2004;190(8):1429-37.
2004: Jill A Livengood; Eric J Fechter; Peter B Dervan; Jennifer K Nyborg
Paradoxical effects of DNA binding polyamides on HTLV-1 transcription.
Frontiers in bioscience : a journal and virtual library 2004;9():3058-67.
2004: Michael A Marques; Raymond M Doss; Shane Foister; Peter B Dervan
Expanding the repertoire of heterocycle ring pairs for programmable minor groove DNA recognition.
Journal of the American Chemical Society 2004;126(33):10339-49.
2004: Eric J Fechter; Bogdan Olenyuk; Peter B Dervan
Design of a sequence-specific DNA bisintercalator.
Angewandte Chemie (International ed. in English) 2004;43(27):3591-4.
2004: Raymond M Doss; Michael A Marques; Shane Foister; Peter B Dervan
DNA minor-groove recognition by 3-methylthiophene/pyrrole pair.
Chemistry & biodiversity 2004;1(6):886-99.
2004: Rajeswari S Edayathumangalam; Philipp Weyermann; Joel M Gottesfeld; Peter B Dervan; Karolin Luger
Molecular recognition of the nucleosomal "supergroove".
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):6864-9.
2004: Doan H Nguyen-Hackley; Elizabeth Ramm; Christina M Taylor; J Keith Joung; Peter B Dervan; Carl O Pabo
Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands.
Biochemistry 2004;43(13):3880-90.
2004: Benjamin S Edelson; Timothy P Best; Bogdan Olenyuk; Nicholas G Nickols; Raymond M Doss; Shane Foister; Alexander Heckel; Peter B Dervan
Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates.
Nucleic acids research 2004;32(9):2802-18.
2003: Adam T Poulin-Kerstien; Peter B Dervan
DNA-templated dimerization of hairpin polyamides.
Journal of the American Chemical Society 2003;125(51):15811-21.
2003: Hans-Dieter Arndt; Karl E Hauschild; David P Sullivan; Kara Lake; Peter B Dervan; Aseem Z Ansari
Toward artificial developmental regulators.
Journal of the American Chemical Society 2003;125(44):13322-3.
2003: Timothy P Best; Benjamin S Edelson; Nicholas G Nickols; Peter B Dervan
Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12063-8.
2003: Shane Foister; Michael A Marques; Raymond M Doss; Peter B Dervan
Shape selective recognition of T.A base pairs by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues.
Bioorganic & medicinal chemistry 2003;11(20):4333-40.
2003: Brigitte Dudouet; Ryan Burnett; Liliane A Dickinson; Malcolm R Wood; Christian Melander; Jason M Belitsky; Benjamin S Edelson; Nicholas R Wurtz; Christoph Briehn; Peter B Dervan; Joel M Gottesfeld
Accessibility of nuclear chromatin by DNA binding polyamides.
Chemistry & biology 2003;10(9):859-67.
2003: Alexander Heckel; Peter B Dervan
U-pin polyamide motif for recognition of the DNA minor groove.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(14):3353-66.
2003: Eric J Fechter; Peter B Dervan
Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates.
Journal of the American Chemical Society 2003;125(28):8476-85.
2003: Peter B Dervan; Benjamin S Edelson
Recognition of the DNA minor groove by pyrrole-imidazole polyamides.
Current opinion in structural biology 2003;13(3):284-99.
2003: Fan Yang; Jason M Belitsky; Rodrigo A Villanueva; Peter B Dervan; Monica J Roth
Inhibition of Moloney murine leukemia virus integration using polyamides targeting the long-terminal repeat sequences.
Biochemistry 2003;42(20):6249-58.
2003: Dorte Renneberg; Peter B Dervan
Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition.
Journal of the American Chemical Society 2003;125(19):5707-16.
2003: Christoph A Briehn; Philipp Weyermann; Peter B Dervan
Alternative heterocycles for DNA recognition: the benzimidazole/imidazole pair.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(9):2110-22.
2003: Bogdan Olenyuk; Cristian Jitianu; Peter B Dervan
Parallel synthesis of H-pin polyamides by alkene metathesis on solid phase.
Journal of the American Chemical Society 2003;125(16):4741-51.
2003: Yong-Dong Wang; Jaroslaw Dziegielewski; Nicholas R Wurtz; Barbara Dziegielewska; Peter B Dervan; Terry Beerman
DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate.
Nucleic acids research 2003;31(4):1208-15.
2003: Robert K Suto; Rajeswari S Edayathumangalam; Cindy L White; Christian Melander; Joel M Gottesfeld; Peter B Dervan; Karolin Luger
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands.
Journal of molecular biology 2003;326(2):371-80.
2003: Victor C Rucker; Shane Foister; Christian Melander; Peter B Dervan
Sequence specific fluorescence detection of double strand DNA.
Journal of the American Chemical Society 2003;125(5):1195-202.
2002: Jason J Coull; Guocheng He; Christian Melander; Victor C Rucker; Peter B Dervan; David M Margolis
Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides.
Journal of virology 2002;76(23):12349-54.
2002: Yong-Dong Wang; Jaroslaw Dziegielewski; Aileen Y Chang; Peter B Dervan; Terry Beerman
Cell-free and cellular activities of a DNA sequence selective hairpin polyamide-CBI conjugate.
The Journal of biological chemistry 2002;277(45):42431-7.
2002: Paramjit S Arora; Aseem Z Ansari; Timothy P Best; Mark Ptashne; Peter B Dervan
Design of artificial transcriptional activators with rigid poly-L-proline linkers.
Journal of the American Chemical Society 2002;124(44):13067-71.
2002: Inger Kers; Peter B Dervan
Search for the optimal linker in tandem hairpin polyamides.
Bioorganic & medicinal chemistry 2002;10(10):3339-49.
2002: Jason M Belitsky; Stephanie J Leslie; Paramjit S Arora; Terry Beerman; Peter B Dervan
Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates.
Bioorganic & medicinal chemistry 2002;10(10):3313-8.
2002: Joel M Gottesfeld; Jason M Belitsky; Christian Melander; Peter B Dervan; Karolin Luger
Blocking transcription through a nucleosome with synthetic DNA ligands.
Journal of molecular biology 2002;321(2):249-63.
2002: Jason M Belitsky; D H Nguyen; Nicholas R Wurtz; Peter B Dervan
Solid-phase synthesis of DNA binding polyamides on oxime resin.
Bioorganic & medicinal chemistry 2002;10(8):2767-74.
2002: Adam R Urbach; John J Love; Scott A Ross; Peter B Dervan
Structure of a beta-alanine-linked polyamide bound to a full helical turn of purine tract DNA in the 1:1 motif.
Journal of molecular biology 2002;320(1):55-71.
2002: Philipp Weyermann; Peter B Dervan
Recognition of ten base pairs of DNA by head-to-head hairpin dimers.
Journal of the American Chemical Society 2002;124(24):6872-8.
2002: Nicholas R Wurtz; JOEL POMERANTZ; David Baltimore; Peter B Dervan
Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides.
Biochemistry 2002;41(24):7604-9.
2002: Jennifer Ehley; Christian Melander; David Herman; Eldon E Baird; Heather A Ferguson; James A Goodrich; Peter B Dervan; Joel M Gottesfeld
Promoter scanning for transcription inhibition with DNA-binding polyamides.
Molecular and cellular biology 2002;22(6):1723-33.
2001: Ching C Wang; Peter B Dervan
Sequence-specific trapping of topoisomerase I by DNA binding polyamide-camptothecin conjugates.
Journal of the American Chemical Society 2001;123(36):8657-61.
2001: Peter B Dervan
Molecular recognition of DNA by small molecules.
Bioorganic & medicinal chemistry 2001;9(9):2215-35.
2001: RE Bremer; Nicholas R Wurtz; JW Szewczyk; Peter B Dervan
Inhibition of major groove DNA binding bZIP proteins by positive patch polyamides.
Bioorganic & medicinal chemistry 2001;9(8):2093-103.
2001: Joel M Gottesfeld; Christian Melander; Robert K Suto; H Raviol; Karolin Luger; Peter B Dervan
Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides.
Journal of molecular biology 2001;309(3):615-29.
2001: Aseem Z Ansari; Anna K Mapp; D H Nguyen; Peter B Dervan; Mark Ptashne
Towards a minimal motif for artificial transcriptional activators.
Chemistry & biology 2001;8(6):583-92.
2001: Nicholas R Wurtz; JM Turner; EE Baird; Peter B Dervan
Fmoc solid phase synthesis of polyamides containing pyrrole and imidazole amino acids.
Organic letters 2001;3(8):1201-3.
2001: A R Urbach; Peter B Dervan
Toward rules for 1:1 polyamide:DNA recognition.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4343-8.
2001: Clay C C Wang; U Ellervik; Peter B Dervan
Expanding the recognition of the minor groove of DNA by incorporation of beta-alanine in hairpin polyamides.
Bioorganic & medicinal chemistry 2001;9(3):653-7.
2001: Ramesh Baliga; Eldon E Baird; D M Herman; Christian Melander; Peter B Dervan; Donald M Crothers
Kinetic consequences of covalent linkage of DNA binding polyamides.
Biochemistry 2001;40(1):3-8.
2001: J W Trauger; Peter B Dervan
Footprinting methods for analysis of pyrrole-imidazole polyamide/DNA complexes.
Methods in enzymology 2001;340():450-66.
2001: D H Nguyen; JW Szewczyk; EE Baird; Peter B Dervan
Alternative heterocycles for DNA recognition: an N-methylpyrazole/N-methylpyrrole pair specifies for A.T/T.A base pairs.
Bioorganic & medicinal chemistry 2001;9(1):7-17.
2000: Christian Melander; D M Herman; Peter B Dervan
Discrimination of A/T sequences in the minor groove of DNA within a cyclic polyamide motif.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(24):4487-97.
2000: Z Y Zhan; Peter B Dervan
Alternative heterocycles for DNA recognition: a 3-pyrazole/pyrrole pair specifies for G.C base pairs.
Bioorganic & medicinal chemistry 2000;8(10):2467-74.
2000: SY Chiang; R W Burli; Christopher C Benz; Loretta S Gawron; Gary K Scott; Peter B Dervan; Terry Beerman
Targeting the ets binding site of the HER2/neu promoter with pyrrole-imidazole polyamides.
The Journal of biological chemistry 2000;275(32):24246-54.
2000: RL Winston; Jennifer Ehley; Eldon E Baird; Peter B Dervan; Joel M Gottesfeld
Asymmetric DNA binding by a homodimeric bHLH protein.
Biochemistry 2000;39(31):9092-8.
2000: RE Bremer; JW Szewczyk; EE Baird; Peter B Dervan
Recognition of the DNA minor groove by pyrrole-imidazole polyamides: comparison of desmethyl- and N-methylpyrrole.
Bioorganic & medicinal chemistry 2000;8(8):1947-55.
2000: Anna K Mapp; Aseem Z Ansari; Mark Ptashne; Peter B Dervan
Activation of gene expression by small molecule transcription factors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3930-5.
2000: Nicholas R Wurtz; Peter B Dervan
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates.
Chemistry & biology 2000;7(3):153-61.
2000: Clara L Kielkopf; RE Bremer; S White; JW Szewczyk; JM Turner; EE Baird; Peter B Dervan; Douglas C Rees
Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove.
Journal of molecular biology 2000;295(3):557-67.
2000: Joel M Gottesfeld; J M Turner; Peter B Dervan
Chemical approaches to control gene expression.
Gene expression 2000;9(1-2):77-91.
1999: Peter B Dervan; R W Bürli
Sequence-specific DNA recognition by polyamides.
Current opinion in chemical biology 1999;3(6):688-93.
1999: Brian A. Lenzmeier; E E Baird; Peter B Dervan; Jennifer K Nyborg
The tax protein-DNA interaction is essential for HTLV-I transactivation in vitro.
Journal of molecular biology 1999;291(4):731-44.
1999: Liliane A Dickinson; JW Trauger; Eldon E Baird; Peter Ghazal; Peter B Dervan; Joel M Gottesfeld
Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides.
Biochemistry 1999;38(33):10801-7.
1999: Liliane A Dickinson; JW Trauger; Eldon E Baird; Peter B Dervan; B J Graves; Joel M Gottesfeld
Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappaB, and DNA by a designed DNA-binding ligand.
The Journal of biological chemistry 1999;274(18):12765-73.
1999: S J McBryant; Eldon E Baird; JW Trauger; Peter B Dervan; Joel M Gottesfeld
Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand.
Journal of molecular biology 1999;286(4):973-81.
1999: Daniel S Pilch; N Poklar; E E Baird; Peter B Dervan; Kenneth J Breslauer
The thermodynamics of polyamide-DNA recognition: hairpin polyamide binding in the minor groove of duplex DNA.
Biochemistry 1999;38(7):2143-51.
1998: Liliane A Dickinson; Rick gulizia; JW Trauger; Eldon E Baird; Donald E Mosier; Joel M Gottesfeld; Peter B Dervan
Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):12890-5.
1998: Clara L Kielkopf; S White; JW Szewczyk; JM Turner; EE Baird; Peter B Dervan; Douglas C Rees
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA.
Science (New York, N.Y.) 1998;282(5386):111-5.
1998: RE Bremer; EE Baird; Peter B Dervan
Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch.
Chemistry & biology 1998;5(3):119-33.
1998: Clara L Kielkopf; EE Baird; Peter B Dervan; Douglas C Rees
Structural basis for G.C recognition in the DNA minor groove.
Nature structural biology 1998;5(2):104-9.
1998: S White; JW Szewczyk; JM Turner; EE Baird; Peter B Dervan
Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands.
Nature 1998;391(6666):468-71.
1997: LS Neely; JW Trauger; Eldon E Baird; Peter B Dervan; Joel M Gottesfeld
Importance of minor groove binding zinc fingers within the transcription factor IIIA-DNA complex.
Journal of molecular biology 1997;274(4):439-45.
1997: S White; EE Baird; Peter B Dervan
On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides.
Chemistry & biology 1997;4(8):569-78.
1997: Joel M Gottesfeld; LS Neely; JW Trauger; Eldon E Baird; Peter B Dervan
Regulation of gene expression by small molecules.
Nature 1997;387(6629):202-5.
1997: M J Taylor; Peter B Dervan
Kinetic analysis of sequence-specific alkylation of DNA by pyrimidine oligodeoxyribonucleotide-directed triple-helix formation.
Bioconjugate chemistry 1997;8(3):354-64.
1996: S White; E E Baird; Peter B Dervan
Effects of the A.T/T.A degeneracy of pyrrole--imidazole polyamide recognition in the minor groove of DNA.
Biochemistry 1996;35(38):12532-7.
1996: Kathryn B Grant; Peter B Dervan
Sequence-specific alkylation and cleavage of DNA mediated by purine motif triple helix formation.
Biochemistry 1996;35(38):12313-9.
1996: D A Liberles; Peter B Dervan
Design of artificial sequence-specific DNA bending ligands.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9510-4.
1996: JW Trauger; E E Baird; Peter B Dervan
Recognition of DNA by designed ligands at subnanomolar concentrations.
Nature 1996;382(6591):559-61.
1996: J J Kelly; E E Baird; Peter B Dervan
Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):6981-5.
1996: M E Parks; Peter B Dervan
Simultaneous binding of a polyamide dimer and an oligonucleotide in the minor and major grooves of DNA.
Bioorganic & medicinal chemistry 1996;4(7):1045-50.
1996: H Brunar; Peter B Dervan
Sequence composition effects on the stabilities of triple helix formation by oligonucleotides containing N7-deoxyguanosine.
Nucleic acids research 1996;24(11):1987-91.
1996: JW Trauger; E E Baird; Peter B Dervan
Extended hairpin polyamide motif for sequence-specific recognition in the minor groove of DNA.
Chemistry & biology 1996;3(5):369-77.
1996: E Wang; K M Koshlap; P Gillespie; Peter B Dervan; Juli Feigon
Solution structure of a pyrimidine-purine-pyrimidine triplex containing the sequence-specific intercalating non-natural base D3.
Journal of molecular biology 1996;257(5):1052-69.
1996: B H Geierstanger; M Mrksich; Peter B Dervan; David E Wemmer
Extending the recognition site of designed minor groove binding molecules.
Nature structural biology 1996;3(4):321-4.
1995: Ramesh Baliga; J W Singleton; Peter B Dervan
RecA.oligonucleotide filaments bind in the minor groove of double-stranded DNA.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10393-7.
1995: J Cho; M E Parks; Peter B Dervan
Cyclic polyamides for recognition in the minor groove of DNA.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10389-92.
1994: B H Geierstanger; M Mrksich; Peter B Dervan; David E Wemmer
Design of a G.C-specific DNA minor groove-binding peptide.
Science (New York, N.Y.) 1994;266(5185):646-50.
1994: H Han; A Schepartz; M Pellegrini; Peter B Dervan
Mapping RNA regions in eukaryotic ribosomes that are accessible to methidiumpropyl-EDTA.Fe(II) and EDTA.Fe(II).
Biochemistry 1994;33(33):9831-44.
1994: H Han; Peter B Dervan
Different conformational families of pyrimidine.purine.pyrimidine triple helices depending on backbone composition.
Nucleic acids research 1994;22(14):2837-44.
1994: A B Staubli; Peter B Dervan
Sequence specificity of the non-natural pyrido[2,3-d]pyrimidine nucleoside in triple helix formation.
Nucleic acids research 1994;22(13):2637-42.
1994: H Han; Peter B Dervan
Visualization of RNA tertiary structure by RNA-EDTA.Fe(II) autocleavage: analysis of tRNA(Phe) with uridine-EDTA.Fe(II) at position 47.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4955-9.
1994: J G Hacia; Peter B Dervan; Barbara J Wold
Inhibition of Klenow fragment DNA polymerase on double-helical templates by oligonucleotide-directed triple-helix formation.
Biochemistry 1994;33(20):6192-200.
1994: J G Hacia; Barbara J Wold; Peter B Dervan
Phosphorothioate oligonucleotide-directed triple helix formation.
Biochemistry 1994;33(18):5367-9.
1994: M G Oakley; K D Turnbull; Peter B Dervan
Synthesis of a hybrid protein containing the iron-binding ligand of bleomycin and the DNA-binding domain of Hin.
Bioconjugate chemistry 1994;5(3):242-7.
1994: B H Geierstanger; Jens Peter Jacobsen; M Mrksich; Peter B Dervan; David E Wemmer
Structural and dynamic characterization of the heterodimeric and homodimeric complexes of distamycin and 1-methylimidazole-2-carboxamide-netropsin bound to the minor groove of DNA.
Biochemistry 1994;33(10):3055-62.
1993: Scott Singleton; Peter B Dervan
Equilibrium association constants for oligonucleotide-directed triple helix formation at single DNA sites: linkage to cation valence and concentration.
Biochemistry 1993;32(48):13171-9.
1993: Warren Wade; M Mrksich; Peter B Dervan
Binding affinities of synthetic peptides, pyridine-2-carboxamidonetropsin and 1-methylimidazole-2-carboxamidonetropsin, that form 2:1 complexes in the minor groove of double-helical DNA.
Biochemistry 1993;32(42):11385-9.
1993: J A Feng; M Simon; D P Mack; Peter B Dervan; Reid C Johnson; Richard E Dickerson
Crystallization and preliminary X-ray analysis of the DNA binding domain of the Hin recombinase with its DNA binding site.
Journal of molecular biology 1993;232(3):982-6.
1993: H Han; Peter B Dervan
Sequence-specific recognition of double helical RNA and RNA.DNA by triple helix formation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):3806-10.
1993: H U Stilz; Peter B Dervan
Specific recognition of CG base pairs by 2-deoxynebularine within the purine.purine.pyrimidine triple-helix motif.
Biochemistry 1993;32(9):2177-85.
1993: M D Distefano; Peter B Dervan
Energetics of cooperative binding of oligonucleotides with discrete dimerization domains to DNA by triple helix formation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1179-83.
1993: B L Iverson; Peter B Dervan
Adenine-specific DNA chemical sequencing reaction.
Methods in enzymology 1993;218():222-7.
1992: Scott Singleton; Peter B Dervan
Influence of pH on the equilibrium association constants for oligodeoxyribonucleotide-directed triple helix formation at single DNA sites.
Biochemistry 1992;31(45):10995-1003.
1992: M G Oakley; M Mrksich; Peter B Dervan
Evidence that a minor groove-binding peptide and a major groove-binding protein can simultaneously occupy a common site on DNA.
Biochemistry 1992;31(45):10969-75.
1992: D P Mack; Peter B Dervan
Sequence-specific oxidative cleavage of DNA by a designed metalloprotein, Ni(II).GGH(Hin139-190).
Biochemistry 1992;31(39):9399-405.
1992: Peter B Dervan
Reagents for the site-specific cleavage of megabase DNA.
Nature 1992;359(6390):87-8.
1992: M Mrksich; Warren Wade; T J Dwyer; B H Geierstanger; David E Wemmer; Peter B Dervan
Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7586-90.
1992: K J Luebke; Peter B Dervan
Nonenymatic ligation of double-helical DNA by alternate-strand triple helix formation.
Nucleic acids research 1992;20(12):3005-9.
1992: P A Beal; Peter B Dervan
The influence of single base triplet changes on the stability of a pur.pur.pyr triple helix determined by affinity cleaving.
Nucleic acids research 1992;20(11):2773-6.
1992: L L Kiessling; L C Griffin; Peter B Dervan
Flanking sequence effects within the pyrimidine triple-helix motif characterized by affinity cleaving.
Biochemistry 1992;31(10):2829-34.
1992: L J Maher; Peter B Dervan; Barbara J Wold
Analysis of promoter-specific repression by triple-helical DNA complexes in a eukaryotic cell-free transcription system.
Biochemistry 1992;31(1):70-81.
1992: Scott A Strobel; Peter B Dervan
Triple helix-mediated single-site enzymatic cleavage of megabase genomic DNA.
Methods in enzymology 1992;216():309-21.
1991: Scott A Strobel; L A Doucette-Stamm; L Riba; David E Housman; Peter B Dervan
Site-specific cleavage of human chromosome 4 mediated by triple-helix formation.
Science (New York, N.Y.) 1991;254(5038):1639-42.
1991: J A Shin; Richard H. Ebright; Peter B Dervan
Orientation of the Lac repressor DNA binding domain in complex with the left lac operator half site characterized by affinity cleaving.
Nucleic acids research 1991;19(19):5233-6.
1991: D A Horne; Peter B Dervan
Effects of an abasic site on triple helix formation characterized by affinity cleaving.
Nucleic acids research 1991;19(18):4963-5.
1991: P A Beal; Peter B Dervan
Second structural motif for recognition of DNA by oligonucleotide-directed triple-helix formation.
Science (New York, N.Y.) 1991;251(4999):1360-3.
1991: Scott A Strobel; Peter B Dervan
Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation.
Nature 1991;350(6314):172-4.
1991: L J Maher; Barbara J Wold; Peter B Dervan
Oligonucleotide-directed DNA triple-helix formation: an approach to artificial repressors?
Antisense research and development 1991;1(3):277-81.
1990: G Eric Plum; Y W Park; Scott Singleton; Peter B Dervan; Kenneth J Breslauer
Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: a spectroscopic and calorimetric study.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9436-40.
1990: R Häner; Peter B Dervan
Single-strand DNA triple-helix formation.
Biochemistry 1990;29(42):9761-5.
1990: K S Graham; Peter B Dervan
Structural motif of the DNA binding domain of gamma delta-resolvase characterized by affinity cleaving.
The Journal of biological chemistry 1990;265(27):16534-40.
1990: L J Maher; Peter B Dervan; Barbara J Wold
Kinetic analysis of oligodeoxyribonucleotide-directed triple-helix formation on DNA.
Biochemistry 1990;29(37):8820-6.
1990: D P Mack; James Sluka; J A Shin; J H Griffin; M I Simon; Peter B Dervan
Orientation of the putative recognition helix in the DNA-binding domain of Hin recombinase complexed with the hix site.
Biochemistry 1990;29(28):6561-7.
1990: James Sluka; S J Horvath; A C Glasgow; M I Simon; Peter B Dervan
Importance of minor-groove contacts for recognition of DNA by the binding domain of Hin recombinase.
Biochemistry 1990;29(28):6551-61.
1990: Scott A Strobel; Peter B Dervan
Site-specific cleavage of a yeast chromosome by oligonucleotide-directed triple-helix formation.
Science (New York, N.Y.) 1990;249(4964):73-5.
1990: M G Oakley; Peter B Dervan
Structural motif of the GCN4 DNA binding domain characterized by affinity cleaving.
Science (New York, N.Y.) 1990;248(4957):847-50.
1989: L C Griffin; Peter B Dervan
Recognition of thymine adenine.base pairs by guanine in a pyrimidine triple helix motif.
Science (New York, N.Y.) 1989;245(4921):967-71.
1989: L J Maher; Barbara J Wold; Peter B Dervan
Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation.
Science (New York, N.Y.) 1989;245(4919):725-30.
1988: B L Iverson; Peter B Dervan
Nonenzymatic sequence-specific methyl transfer to single-stranded DNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4615-9.
1987: James Sluka; S J Horvath; M F Bruist; M I Simon; Peter B Dervan
Synthesis of a sequence-specific DNA-cleaving peptide.
Science (New York, N.Y.) 1987;238(4830):1129-32.
1987: Heinz Moser; Peter B Dervan
Sequence-specific cleavage of double helical DNA by triple helix formation.
Science (New York, N.Y.) 1987;238(4827):645-50.
1987: B L Iverson; Peter B Dervan
Adenine specific DNA chemical sequencing reaction.
Nucleic acids research 1987;15(19):7823-30.
1984: P G Schultz; Peter B Dervan
Distamycin and penta-N-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving.
Journal of biomolecular structure & dynamics 1984;1(5):1133-47.