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Rik Derynck

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Samy Lamouille; Deepa Subramanyam; Robert Blelloch; Rik Derynck
Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.
Masayo Sakaki-Yumoto; Yoko Katsuno; Rik Derynck
TGF-β family signaling in stem cells.
Yoko Katsuno; Samy Lamouille; Rik Derynck
TGF-β signaling and epithelial-mesenchymal transition in cancer progression.

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All Publications

2013: Samy Lamouille; Deepa Subramanyam; Robert Blelloch; Rik Derynck
Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.
Current opinion in cell biology 2013;25(2):200-7.
2013: Masayo Sakaki-Yumoto; Yoko Katsuno; Rik Derynck
TGF-β family signaling in stem cells.
Biochimica et biophysica acta 2013;1830(2):2280-96.
2013: Yoko Katsuno; Samy Lamouille; Rik Derynck
TGF-β signaling and epithelial-mesenchymal transition in cancer progression.
Current opinion in oncology 2013;25(1):76-84.
2012: Pinglong Xu; Jianming Liu; Rik Derynck
Post-translational regulation of TGF-β receptor and Smad signaling.
FEBS letters 2012;586(14):1871-84.
2012: Pinglong Xu; Jianming Liu; Masayo Sakaki-Yumoto; Rik Derynck
TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association.
Science signaling 2012;5(222):ra34.
2012: Samy Lamouille; James W Smyth; Rosemary J Akhurst; Erin Connolly; Rik Derynck
TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.
Journal of cell science 2012;125(Pt 5):1259-73.
2011: Geeta Upadhyay; Yuzhi Yin; Hongyan Yuan; Xin Li; Rik Derynck; Robert I Glazer
Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7820-5.
2011: Deepa Subramanyam; Samy Lamouille; Robert L Judson; Jason Y Liu; Nathan Bucay; Rik Derynck; Robert Blelloch
Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells.
Nature biotechnology 2011;29(5):443-8.
2011: Samy Lamouille; Rik Derynck
Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition.
Cells, tissues, organs 2011;193(1-2):8-22.
2010: Jolie L Chang; Delia S Brauer; Jacob Johnson; Carol G Chen; Omar Akil; Guive Balooch; Mary Beth Humphrey; Emily N Chin; Alexandra E Porter; Kristin Butcher; Robert O Ritchie; Richard Schneider; Anil Lalwani; Rik Derynck; Grayson William Marshall; Sally J Marshall; Lawrence Lustig; Tamara Alliston
Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing.
EMBO reports 2010;11(10):765-71.
2010: Pinglong Xu; Rik Derynck
Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation.
Molecular cell 2010;37(4):551-66.
2009: Samy Lamouille; Rik Derynck
Oncogene and tumour suppressor: the two faces of SnoN.
The EMBO journal 2009;28(22):3459-60.
2009: Denise M Piscopo; Eric B Johansen; Rik Derynck
Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter.
The Journal of biological chemistry 2009;284(46):31690-703.
2009: Kristi Wharton; Rik Derynck
TGFbeta family signaling: novel insights in development and disease.
Development (Cambridge, England) 2009;136(22):3691-7.
2009: Jong Seok Kang; Cheng Liu; Rik Derynck
New regulatory mechanisms of TGF-beta receptor function.
Trends in cell biology 2009;19(8):385-94.
2009: Cheng Liu; Pinglong Xu; Samy Lamouille; Jian Xu; Rik Derynck
TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling.
Molecular cell 2009;35(1):26-36.
2009: Liyu Wu; Rik Derynck
Essential role of TGF-beta signaling in glucose-induced cell hypertrophy.
Developmental cell 2009;17(1):35-48.
2009: Jian Xu; Samy Lamouille; Rik Derynck
TGF-beta-induced epithelial to mesenchymal transition.
Cell research 2009;19(2):156-72.
2009: Irwin M Liu; Stephen H Schilling; Kristin A Knouse; Lisa Choy; Rik Derynck; Xiao-Fan Wang
TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.
The EMBO journal 2009;28(2):88-98.
2009: Khalid S Mohammad; Carol G Chen; Guive Balooch; Elizabeth Stebbins; C Ryan McKenna; Holly Davis; Maria Niewolna; Xiang Hong Peng; Daniel H N Nguyen; Sophi S Ionova-Martin; John W Bracey; William R Hogue; Darren H Wong; Robert O Ritchie; Larry J Suva; Rik Derynck; Theresa A Guise; Tamara Alliston
Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone.
PloS one 2009;4(4):e5275.
2008: Isabella Imhof; Warren J Gasper; Rik Derynck
Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization.
Journal of cell science 2008;121(Pt 13):2265-74.
2008: Jong Seok Kang; Elise F Saunier; Rosemary J Akhurst; Rik Derynck
The type I TGF-beta receptor is covalently modified and regulated by sumoylation.
Nature cell biology 2008;10(6):654-64.
2007: Matt K Lee; Cécile Pardoux; Marie C Hall; Pierre S Lee; David Warburton; Jing Qing; Susan M Smith; Rik Derynck
TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA.
The EMBO journal 2007;26(17):3957-67.
2007: Rik Derynck; Rosemary J Akhurst
Differentiation plasticity regulated by TGF-beta family proteins in development and disease.
Nature cell biology 2007;9(9):1000-4.
2007: Samy Lamouille; Rik Derynck
Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway.
The Journal of cell biology 2007;178(3):437-51.
2007: Carolina Perez Castro; Denise Piscopo; Takatoshi Nakagawa; Rik Derynck
Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells.
Journal of cell science 2007;120(Pt 14):2454-66.
2006: Derrick C Wan; Oliver O Aalami; Zhen Wang; Randall P Nacamuli; Florence Lorget; Rik Derynck; Michael T Longaker
Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone.
Plastic and reconstructive surgery 2006;118(4):851-61.
2005: Guive Balooch; Mehdi Balooch; Ravi K Nalla; Stephen Schilling; Ellen H Filvaroff; Grayson William Marshall; Sally J Marshall; Robert O Ritchie; Rik Derynck; Tamara Alliston
TGF-beta regulates the mechanical properties and composition of bone matrix.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):18813-8.
2005: Lopa Mishra; Rik Derynck; Bibhuti Mishra
Transforming growth factor-beta signaling in stem cells and cancer.
Science (New York, N.Y.) 2005;310(5745):68-71.
2005: Bin Y Qin; Cheng Liu; Hema Srinath; Suvana S Lam; John J Correia; Rik Derynck; Kai Lin
Crystal structure of IRF-3 in complex with CBP.
Structure (London, England : 1993) 2005;13(9):1269-77.
2005: Takatoshi Nakagawa; Annabel Guichard; Carolina Perez Castro; Yang Xiao; Michael Rizen; Hong-Zhong Zhang; Diane Hu; Anne Bang; Jill Helms; Ethan Bier; Rik Derynck
Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;233(4):1315-31.
2005: Jong Seok Kang; Tamara Alliston; Rachel Delston; Rik Derynck
Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.
The EMBO journal 2005;24(14):2543-55.
2005: Tamara Alliston; Tien C Ko; Yanna Cao; Yao-Yun Liang; Xin-Hua Feng; Chenbei Chang; Rik Derynck
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1.
The Journal of biological chemistry 2005;280(25):24227-37.
2005: Xin-Hua Feng; Rik Derynck
Specificity and versatility in tgf-beta signaling through Smads.
Annual review of cell and developmental biology 2005;21():659-93.
2004: Cécile Pardoux; Rik Derynck
JNK regulates expression and autocrine signaling of TGF-beta1.
Molecular cell 2004;15(2):170-1.
2004: Dong Liu; Jong Seok Kang; Rik Derynck
TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation.
The EMBO journal 2004;23(7):1557-66.
2004: Jing Qing; Cheng Liu; Lisa Choy; Rui-Yun Wu; Joseph S Pagano; Rik Derynck
Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter.
Molecular and cellular biology 2004;24(3):1411-25.
2003: Bin Y Qin; Cheng Liu; Suvana S Lam; Hema Srinath; Rachel Delston; John J Correia; Rik Derynck; Kai Lin
Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation.
Nature structural biology 2003;10(11):913-21.
2003: Rik Derynck; Ying E Zhang
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
Nature 2003;425(6958):577-84.
2003: Pierre S W Lee; Chenbei Chang; Dong Liu; Rik Derynck
Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling.
The Journal of biological chemistry 2003;278(30):27853-63.
2003: Huizhou Fan; Christoph W Turck; Rik Derynck
Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide.
The Journal of biological chemistry 2003;278(20):18617-27.
2003: Lisa Choy; Rik Derynck
Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function.
The Journal of biological chemistry 2003;278(11):9609-19.
2002: Jeremy Skillington; Lisa Choy; Rik Derynck
Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes.
The Journal of cell biology 2002;159(1):135-46.
2002: Changgong Li; Nian-Ling Zhu; Rosemarie C Tan; Philip L Ballard; Rik Derynck; Parviz Minoo
Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors.
The Journal of biological chemistry 2002;277(41):38399-408.
2002: Tamara Alliston; Rik Derynck
Medicine: interfering with bone remodelling.
Nature 2002;416(6882):686-7.
2001: Dong Liu; B L Black; Rik Derynck
TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3.
Genes & development 2001;15(22):2950-66.
2001: Rik Derynck; Rosemary J Akhurst; Allan Balmain
TGF-beta signaling in tumor suppression and cancer progression.
Nature genetics 2001;29(2):117-29.
2001: Tamara Alliston; Lisa Choy; P Ducy; G Karsenty; Rik Derynck
TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation.
The EMBO journal 2001;20(9):2254-72.
2000: Supriya Patil; Gary M Wildey; T L Brown; Lisa Choy; Rik Derynck; Thomas Brown
Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis.
The Journal of biological chemistry 2000;275(49):38363-70.
2000: Jing Qing; Y Zhang; Rik Derynck
Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.
The Journal of biological chemistry 2000;275(49):38802-12.
2000: A Kuo; C Zhong; William Stratton Lane; Rik Derynck
Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55.
The EMBO journal 2000;19(23):6427-39.
2000: XH Feng; X Lin; Rik Derynck
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta.
The EMBO journal 2000;19(19):5178-93.
2000: Y Zhang; Rik Derynck
Transcriptional regulation of the transforming growth factor-beta -inducible mouse germ line Ig alpha constant region gene by functional cooperation of Smad, CREB, and AML family members.
The Journal of biological chemistry 2000;275(22):16979-85.
2000: Lisa Choy; J Skillington; Rik Derynck
Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation.
The Journal of cell biology 2000;149(3):667-82.
2000: W Shi; H Fan; L Shum; Rik Derynck
The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation.
The Journal of cell biology 2000;148(3):591-602.
1999: Ellen H Filvaroff; Adrian Erlebacher; J Ye; S E Gitelman; J Lotz; M Heillman; Rik Derynck
Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass.
Development (Cambridge, England) 1999;126(19):4267-79.
1999: Päivi J Miettinen; Jennie R Chin; L Shum; H C Slavkin; C F Shuler; Rik Derynck; Zena Werb
Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure.
Nature genetics 1999;22(1):69-73.
1998: Rik Derynck; Y Zhang; Xin-Hua Feng
Smads: transcriptional activators of TGF-beta responses.
Cell 1998;95(6):737-40.
1998: Lisa Choy; Rik Derynck
The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response.
The Journal of biological chemistry 1998;273(47):31455-62.
1998: I Griswold-Prenner; Craig Kamibayashi; E M Maruoka; Marc C Mumby; Rik Derynck
Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.
Molecular and cellular biology 1998;18(11):6595-604.
1998: Ellen H Filvaroff; Rik Derynck
Bone remodelling: a signalling system for osteoclast regulation.
Current biology : CB 1998;8(19):R679-82.
1998: vattamattam sebastian; R Gregg Richards; Michael P Walker; JF Wiesen; Z Werb; Rik Derynck; Yun Kit Hom; G R Cunha; Richard P DiAugustine
Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(9):777-85.
1998: Y Zhang; Xin-Hua Feng; Rik Derynck
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.
Nature 1998;394(6696):909-13.
1998: XH Feng; Y Zhang; Rui-Yun Wu; Rik Derynck
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation.
Genes & development 1998;12(14):2153-63.
1998: Adrian Erlebacher; Ellen H Filvaroff; J Q Ye; Rik Derynck
Osteoblastic responses to TGF-beta during bone remodeling.
Molecular biology of the cell 1998;9(7):1903-18.
1998: Agnieszka E Gorska; H Joseph; Rik Derynck; Harold L Moses; Rosa Serra
Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(3):229-38.
1998: Yun Kit Hom; Peter Young; JF Wiesen; Päivi J Miettinen; Rik Derynck; Zena Werb; Gerald R Cunha
Uterine and vaginal organ growth requires epidermal growth factor receptor signaling from stroma.
Endocrinology 1998;139(3):913-21.
1997: M H Verlhac; R H Chen; P Hanachi; John W B Hershey; Rik Derynck
Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation.
The EMBO journal 1997;16(22):6812-22.
1997: Rik Derynck; XH Feng
TGF-beta receptor signaling.
Biochimica et biophysica acta 1997;1333(2):F105-50.
1997: Rosa Serra; M Johnson; Ellen H Filvaroff; J LaBorde; D M Sheehan; Rik Derynck; Harold L Moses
Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis.
The Journal of cell biology 1997;139(2):541-52.
1997: XH Feng; Rik Derynck
A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity.
The EMBO journal 1997;16(13):3912-23.
1997: Päivi J Miettinen; D Warburton; D Bu; J S Zhao; J E Berger; P Minoo; Timo Koivisto; L Allen; L Dobbs; Zena Werb; Rik Derynck
Impaired lung branching morphogenesis in the absence of functional EGF receptor.
Developmental biology 1997;186(2):224-36.
1997: S Lawler; XH Feng; RH Chen; E M Maruoka; Christoph W Turck; I Griswold-Prenner; Rik Derynck
The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues.
The Journal of biological chemistry 1997;272(23):14850-9.
1997: Rui-Yun Wu; Y Zhang; XH Feng; Rik Derynck
Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4.
Molecular and cellular biology 1997;17(5):2521-8.
1997: Y Zhang; T Musci; Rik Derynck
The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function.
Current biology : CB 1997;7(4):270-6.
1997: Xiao-Jing Wang; DA Greenhalgh; Jackie R Bickenbach; A Jiang; Donnie Bundman; T Krieg; Rik Derynck; Dennis R Roop
Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2386-91.
1996: L Shum; Christoph W Turck; Rik Derynck
Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association.
The Journal of biological chemistry 1996;271(45):28502-8.
1996: Rik Derynck; Y Zhang
Intracellular signalling: the mad way to do it.
Current biology : CB 1996;6(10):1226-9.
1996: E H Filvaroff; Rik Derynck
Induction of myogenesis in mesenchymal cells by MyoD depends on their degree of differentiation.
Developmental biology 1996;178(2):459-71.
1996: Y Zhang; Xin-Hua Feng; R We; Rik Derynck
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Nature 1996;383(6596):168-72.
1996: XH Feng; Rik Derynck
Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors.
The Journal of biological chemistry 1996;271(22):13123-9.
1996: Adrian Erlebacher; Rik Derynck
Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype.
The Journal of cell biology 1996;132(1-2):195-210.
1995: XH Feng; E H Filvaroff; Rik Derynck
Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors.
The Journal of biological chemistry 1995;270(41):24237-45.
1995: R H Chen; P J Miettinen; E M Maruoka; L Choy; Rik Derynck
A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor.
Nature 1995;377(6549):548-52.
1995: P J Miettinen; J E Berger; Juanito J Meneses; Yume Phung; R A Pedersen; Zena Werb; Rik Derynck
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor.
Nature 1995;376(6538):337-41.
1995: Stephen E Gitelman; M Kirk; J Q Ye; E H Filvaroff; A J Kahn; Rik Derynck
Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(7):827-36.
1995: R H Chen; H L Moses; E M Maruoka; Rik Derynck; M Kawabata
Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-beta receptors.
The Journal of biological chemistry 1995;270(20):12235-41.
1995: Adrian Erlebacher; E H Filvaroff; Stephen E Gitelman; Rik Derynck
Toward a molecular understanding of skeletal development.
Cell 1995;80(3):371-8.
1994: Rik Derynck
TGF-beta-receptor-mediated signaling.
Trends in biochemical sciences 1994;19(12):548-53.
1994: P J Miettinen; R Ebner; A R Lopez; Rik Derynck
TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.
The Journal of cell biology 1994;127(6 Pt 2):2021-36.
1994: R H Chen; Rik Derynck
Homomeric interactions between type II transforming growth factor-beta receptors.
The Journal of biological chemistry 1994;269(36):22868-74.
1994: Stephen E Gitelman; M S Kobrin; J Q Ye; A R Lopez; A Lee; Rik Derynck
Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo.
The Journal of cell biology 1994;126(6):1595-609.
1994: E H Filvaroff; R Ebner; Rik Derynck
Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor.
Development (Cambridge, England) 1994;120(5):1085-95.
1994: Rik Derynck; R H Chen; R Ebner; E H Filvaroff; S Lawler
An emerging complexity of receptors for transforming growth factor-beta.
Princess Takamatsu symposia 1994;24():264-75.
1994: S Lawler; A F Candia; R Ebner; L Shum; A R Lopez; H L Moses; Christopher V E Wright; Rik Derynck
The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1.
Development (Cambridge, England) 1994;120(1):165-75.
1993: R Ebner; R H Chen; S Lawler; T Zioncheck; Rik Derynck
Determination of type I receptor specificity by the type II receptors for TGF-beta or activin.
Science (New York, N.Y.) 1993;262(5135):900-2.
1993: R Ebner; R H Chen; L Shum; S Lawler; T F Zioncheck; A Lee; A R Lopez; Rik Derynck
Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor.
Science (New York, N.Y.) 1993;260(5112):1344-8.
1993: R H Chen; R Ebner; Rik Derynck
Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities.
Science (New York, N.Y.) 1993;260(5112):1335-8.
1993: D Gazit; R Ebner; A J Kahn; Rik Derynck
Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells.
Molecular endocrinology (Baltimore, Md.) 1993;7(2):189-98.
1992: B A Arrick; A R Lopez; F Elfman; R Ebner; Caroline Damsky; Rik Derynck
Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1.
The Journal of cell biology 1992;118(3):715-26.
1992: A R Lopez; J Cook; P L Deininger; Rik Derynck
Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms.
Molecular and cellular biology 1992;12(4):1674-9.
1992: Rik Derynck
The physiology of transforming growth factor-alpha.
Advances in cancer research 1992;58():27-52.
1991: R M Lyons; D A Miller; J L Graycar; Harold L Moses; Rik Derynck
Differential binding of transforming growth factor-beta 1, -beta 2, and -beta 3 by fibroblasts and epithelial cells measured by affinity cross-linking of cell surface receptors.
Molecular endocrinology (Baltimore, Md.) 1991;5(12):1887-96.
1991: B A Arrick; A L Lee; R L Grendell; Rik Derynck
Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region.
Molecular and cellular biology 1991;11(9):4306-13.
1991: R Ebner; Rik Derynck
Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes.
Cell regulation 1991;2(8):599-612.
1990: B A Arrick; M Korc; Rik Derynck
Differential regulation of expression of three transforming growth factor beta species in human breast cancer cell lines by estradiol.
Cancer research 1990;50(2):299-303.
1990: D A Miller; R W Pelton; Rik Derynck; Harold L Moses
Transforming growth factor-beta. A family of growth regulatory peptides.
Annals of the New York Academy of Sciences 1990;593():208-17.
1989: J L Graycar; D A Miller; B A Arrick; R M Lyons; Harold L Moses; Rik Derynck
Human transforming growth factor-beta 3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2.
Molecular endocrinology (Baltimore, Md.) 1989;3(12):1977-86.
1989: D A Miller; A Lee; Y Matsui; E Y Chen; Harold L Moses; Rik Derynck
Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues.
Molecular endocrinology (Baltimore, Md.) 1989;3(12):1926-34.
1989: C C Bascom; J R Wolfshohl; Robert J Coffey; L Madisen; N R Webb; A R Purchio; Rik Derynck; Harold L Moses
Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2.
Molecular and cellular biology 1989;9(12):5508-15.
1989: D A Miller; A Lee; R W Pelton; E Y Chen; Harold L Moses; Rik Derynck
Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos.
Molecular endocrinology (Baltimore, Md.) 1989;3(7):1108-14.
1989: K Lyons; J L Graycar; A Lee; S Hashmi; P B Lindquist; E Y Chen; B L Hogan; Rik Derynck
Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4554-8.
1989: D Z Wen; A Rowland; Rik Derynck
Expression and secretion of gro/MGSA by stimulated human endothelial cells.
The EMBO journal 1989;8(6):1761-6.
1989: R Brachmann; P B Lindquist; M Nagashima; W Kohr; T Lipari; M Napier; Rik Derynck
Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors.
Cell 1989;56(4):691-700.
1988: Rik Derynck; P B Lindquist; A Lee; D Wen; J Tamm; J L Graycar; L Rhee; A J Mason; D A Miller; R J Coffey
A new type of transforming growth factor-beta, TGF-beta 3.
The EMBO journal 1988;7(12):3737-43.
1988: Rik Derynck
Transforming growth factor alpha.
Cell 1988;54(5):593-5.