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Stephen Desiderio

Research Profile

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Molecular Sequence Data

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Phosphorylation

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TOP 3
Robert H Newman; QIANG NI; Akhilesh Pandey; Tony Pawson; Hee-Sool Rho; Alexey G Ryazanov; Matthew Shirley; Benjamin E Turk; Crystal Woodard; George Wu; SHULI XIA; Zhi Xie; Donald J Zack; Jin Zhang; Heng Zhu; Jun Seop Jeong; Morris J Birnbaum; Seth Blackshaw; Hillary M Clark; Philip A Cole; Christopher Cooper; Kevin N Dalby; Stephen Desiderio; Xinxin Gao; Anne-Claude Gingras; Renu Goel; Jianfei Hu; Shaohui Hu; Woochang Hwang; Hongkai Ji; Stefan Knapp; Jimmy Lin; John Neiswinger; Jiang Qian
Construction of human activity-based phosphorylation networks.
Puspa Thapa; Rhianna Sundsbak; Sarah Tangen; Joshua Anderson; Joy Das; Stephen Desiderio; Scott Hiebert; Douglas McWilliams; Molly Nelson-Holte; Derek B Sant'Angelo; Michael Shapiro; Virginia Smith Shapiro
The transcriptional repressor NKAP is required for the development of iNKT cells.
Christopher L Cooper; Richard R Hardy; Michael Reth; Stephen Desiderio
Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors.

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All Publications

2013: Robert H Newman; QIANG NI; Akhilesh Pandey; Tony Pawson; Hee-Sool Rho; Alexey G Ryazanov; Matthew Shirley; Benjamin E Turk; Crystal Woodard; George Wu; SHULI XIA; Zhi Xie; Donald J Zack; Jin Zhang; Heng Zhu; Jun Seop Jeong; Morris J Birnbaum; Seth Blackshaw; Hillary M Clark; Philip A Cole; Christopher Cooper; Kevin N Dalby; Stephen Desiderio; Xinxin Gao; Anne-Claude Gingras; Renu Goel; Jianfei Hu; Shaohui Hu; Woochang Hwang; Hongkai Ji; Stefan Knapp; Jimmy Lin; John Neiswinger; Jiang Qian
Construction of human activity-based phosphorylation networks.
Molecular systems biology 2013;9():655.
2013: Puspa Thapa; Rhianna Sundsbak; Sarah Tangen; Joshua Anderson; Joy Das; Stephen Desiderio; Scott Hiebert; Douglas McWilliams; Molly Nelson-Holte; Derek B Sant'Angelo; Michael Shapiro; Virginia Smith Shapiro
The transcriptional repressor NKAP is required for the development of iNKT cells.
Nature communications 2013;4():1582.
2012: Christopher L Cooper; Richard R Hardy; Michael Reth; Stephen Desiderio
Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors.
Blood 2012;119(23):5438-48.
2012: Sarah Greenblatt; David L Huso; Li Li; Bao Nguyen; Rachel Novak; Christopher Slape; Peter D Aplan; Michael J Borowitz; Stephen Desiderio; Amy Duffield; Donald Small
Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.
Blood 2012;119(12):2883-94.
2011: Li Li; Li Zhang; Jinshui Fan; Kathleen Greenberg; Stephen Desiderio; Feyruz V Rassool; Donald Small
Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice.
Blood 2011;117(11):3131-9.
2011: Li Zhang; Taylor Reynolds; Xiaochuan Shan; Stephen Desiderio
Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.
Immunity 2011;34(2):163-74.
2010: Stephen Desiderio
Temporal and spatial regulatory functions of the V(D)J recombinase.
Seminars in immunology 2010;22(6):362-9.
2010: Richard Kumaran Kandasamy; S Sujatha Mohan; Rajesh Raju; Shivakumar Keerthikumar; Ghantasala S Sameer Kumar; Abhilash K Venugopal; Deepthi Telikicherla; J Daniel Navarro; M Suresh; Christian Pecquet; Sashi Kanth Gollapudi; Sudhir Gopal Tattikota; Shyam Mohan; Hariprasad Padhukasahasram; Yashwanth Subbannayya; renu goel; Harrys K C Jacob; Jun Zhong; Raja Sekhar; Vishalakshi Nanjappa; Lavanya Balakrishnan; Roopashree Subbaiah; Y L Ramachandra; B Abdul Rahiman; T S Keshava Prasad; Jian-Xin Lin; Jon C D Houtman; Stephen Desiderio; Jean-Christophe Renauld; Stefan N Constantinescu; Osamu Ohara; Toshio Hirano; Masato Kubo; Sujay Singh; Purvesh Khatri; Sorin Draghici; Gary D Bader; Chris Sander; Warren J Leonard; Akhilesh Pandey
NetPath: a public resource of curated signal transduction pathways.
Genome biology 2010;11(1):R3.
2009: Nicholas Constantine Zachos; Damian B van Rossum; Xuhang Li; Gabriela Caraveo; RAFIQUEL SARKER; Boyoung Cha; Sachin Mohan; Stephen Desiderio; Randen L Patterson; Mark Donowitz
Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.
The Journal of biological chemistry 2009;284(29):19437-44.
2009: Yun Liu; Li Zhang; Stephen Desiderio
Temporal and spatial regulation of V(D)J recombination: interactions of extrinsic factors with the RAG complex.
Advances in experimental medicine and biology 2009;650():157-65.
2008: Stephen Desiderio
Along came a spider: AID escapes a microRNA web.
Immunity 2008;28(5):596-8.
2008: Heather A Marton; Stephen Desiderio
The Paf1 complex promotes displacement of histones upon rapid induction of transcription by RNA polymerase II.
BMC molecular biology 2008;9():4.
2007: Min-Young Youn; Hyun-Seok Yoo; Min-Jung Kim; Sun-Young Hwang; Yongwook Choi; Stephen Desiderio; JY Yoo
hCTR9, a component of Paf1 complex, participates in the transcription of interleukin 6-responsive genes through regulation of STAT3-DNA interactions.
The Journal of biological chemistry 2007;282(48):34727-34.
2007: Yun Liu; Ramesh Subrahmanyam; Tirtha Chakraborty; RANJAN SEN; Stephen Desiderio
A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.
Immunity 2007;27(4):561-71.
2006: Gabriela Caraveo; Damian B van Rossum; Randen L Patterson; Solomon H Snyder; Stephen Desiderio
Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry.
Science (New York, N.Y.) 2006;314(5796):122-5.
2005: Tanisha Anne Jackson; Harry E Taylor; Deva Sharma; Stephen Desiderio; Sonye K Danoff
Vascular endothelial growth factor receptor-2: counter-regulation by the transcription factors, TFII-I and TFII-IRD1.
The Journal of biological chemistry 2005;280(33):29856-63.
2005: Hao Jiang; Fu-Chung Chang; Ashley E Ross; Jihyun Lee; Keiichi Nakayama; Keiko Nakayama; Stephen Desiderio
Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.
Molecular cell 2005;18(6):699-709.
2004: Hao Jiang; Ashley E Ross; Stephen Desiderio
Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins.
The Journal of biological chemistry 2004;279(9):8478-86.
2004: Sonye K Danoff; H E Taylor; Seth Blackshaw; Stephen Desiderio
TFII-I, a candidate gene for Williams syndrome cognitive profile: parallels between regional expression in mouse brain and human phenotype.
Neuroscience 2004;123(4):931-8.
2003: Theresa Tretter; Ashley E Ross; Dominic I Dordai; Stephen Desiderio
Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk.
The Journal of experimental medicine 2003;198(12):1863-73.
2003: Ashley E Ross; Milena Vuica; Stephen Desiderio
Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.
Molecular and cellular biology 2003;23(15):5308-19.
2003: Stephen Desiderio; JY Yoo
A genome-wide analysis of the acute-phase response and its regulation by Stat3beta.
Annals of the New York Academy of Sciences 2003;987():280-4.
2003: JY Yoo; Stephen Desiderio
Innate and acquired immunity intersect in a global view of the acute-phase response.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1157-62.
2002: Darren E Casteel; Shunhui Zhuang; Tanima Gudi; Julian Tang; Milena Vuica; Stephen Desiderio; Renate B Pilz
cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I.
The Journal of biological chemistry 2002;277(35):32003-14.
2002: JY Yoo; David L Huso; Daniel Nathans; Stephen Desiderio
Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock.
Cell 2002;108(3):331-44.
2001: A M Egloff; Stephen Desiderio
Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I.
The Journal of biological chemistry 2001;276(30):27806-15.
2001: JY Yoo; W Wang; Stephen Desiderio; Daniel Nathans
Synergistic activity of STAT3 and c-Jun at a specific array of DNA elements in the alpha 2-macroglobulin promoter.
The Journal of biological chemistry 2001;276(28):26421-9.
2001: W Li; F C Chang; Stephen Desiderio
Rag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination.
Molecular and cellular biology 2001;21(12):3935-46.
2000: Stephen Desiderio
Somatic evolution of antibody specificity: setting the clock forward.
Nature immunology 2000;1(6):463-4.
2000: G Texido; I H Su; Ingrid Mecklenbräuker; Kaoru Saijo; Sami Malek; Stephen Desiderio; Klaus Rajewsky; Alexander Tarakhovsky
The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation.
Molecular and cellular biology 2000;20(4):1227-33.
2000: Stephen Desiderio; J Lee
Signaling pathways that control V(D)J recombination.
Current topics in microbiology and immunology 2000;245(2):31-56.
1999: J Lee; Stephen Desiderio
Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair.
Immunity 1999;11(6):771-81.
1999: Patrick C Swanson; Stephen Desiderio
RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex.
Molecular and cellular biology 1999;19(5):3674-83.
1998: Patrick C Swanson; Stephen Desiderio
V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.
Immunity 1998;9(1):115-25.
1998: Sami Malek; D I Dordai; J Reim; HOWARD DINTZIS; Stephen Desiderio
Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7351-6.
1997: W Li; Patrick C Swanson; Stephen Desiderio
RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution.
Molecular and cellular biology 1997;17(12):6932-9.
1997: Stephen Desiderio
Role of Btk in B cell development and signaling.
Current opinion in immunology 1997;9(4):534-40.
1997: Milena Vuica; Stephen Desiderio; Jonathan P Schneck
Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62.
The Journal of experimental medicine 1997;186(2):259-67.
1997: Patty Zwollo; H Arrieta; K Ede; K Molinder; Stephen Desiderio; R Pollock
The Pax-5 gene is alternatively spliced during B-cell development.
The Journal of biological chemistry 1997;272(15):10160-8.
1997: W Yang; Stephen Desiderio
BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):604-9.
1996: Z Li; D I Dordai; J Lee; Stephen Desiderio
A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle.
Immunity 1996;5(6):575-89.
1996: K Schwarz; G H Gauss; L Ludwig; U Pannicke; Z Li; D Lindner; Wilhelm Friedrich; R A Seger; T E Hansen-Hagge; Stephen Desiderio; Michael R Lieber; Claus R Bartram
RAG mutations in human B cell-negative SCID.
Science (New York, N.Y.) 1996;274(5284):97-9.
1996: Sami Malek; C H Yang; William C Earnshaw; C A Kozak; Stephen Desiderio
p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains.
The Journal of biological chemistry 1996;271(12):6952-62.
1996: Stephen Desiderio; W C Lin; Z Li
The cell cycle and V(D)J recombination.
Current topics in microbiology and immunology 1996;217():45-59.
1995: W Yang; Sami Malek; Stephen Desiderio
An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo.
The Journal of biological chemistry 1995;270(35):20832-40.
1995: W C Lin; Stephen Desiderio
V(D)J recombination and the cell cycle.
Immunology today 1995;16(6):279-89.
1995: Stephen Desiderio
Lymphopoiesis. Transcription factors controlling B-cell development.
Current biology : CB 1995;5(6):605-8.
1994: Sami Malek; Stephen Desiderio
A cyclin-dependent kinase homologue, p130PITSLRE is a phosphotyrosine-independent SH2 ligand.
The Journal of biological chemistry 1994;269(52):33009-20.
1994: E M Janis; Janet D Siliciano; D D Isaac; Constance A Griffin; Anita L Hawkins; C A Kozak; Stephen Desiderio
Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q.
Genomics 1994;23(1):269-71.
1994: P Zwollo; Stephen Desiderio
Specific recognition of the blk promoter by the B-lymphoid transcription factor B-cell-specific activator protein.
The Journal of biological chemistry 1994;269(21):15310-7.
1994: Stephen Desiderio
The B cell antigen receptor in B-cell development.
Current opinion in immunology 1994;6(2):248-56.
1994: W C Lin; Stephen Desiderio
Cell cycle regulation of V(D)J recombination-activating protein RAG-2.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2733-7.
1994: Stephen Desiderio; Janet D Siliciano
The Itk/Btk/Tec family of protein-tyrosine kinases.
Chemical immunology 1994;59():191-210.
1994: Mario Amzel; K C Garcia; Stephen Desiderio
Do antiidiotypic antibodies mimic antigen?
Research in immunology 1994;145(1):53-5.
1993: Sami Malek; Stephen Desiderio
SH2 domains of the protein-tyrosine kinases Blk, Lyn, and Fyn(T) bind distinct sets of phosphoproteins from B lymphocytes.
The Journal of biological chemistry 1993;268(30):22557-65.
1993: E M Oltz; F W Alt; W C Lin; J Chen; Guillermo E Taccioli; Stephen Desiderio; GA Rathbun
A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.
Molecular and cellular biology 1993;13(10):6223-30.
1993: R L Wange; Sami Malek; Stephen Desiderio; Lawrence E Samelson
Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.
The Journal of biological chemistry 1993;268(26):19797-801.
1993: W C Lin; Stephen Desiderio
Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation.
Science (New York, N.Y.) 1993;260(5110):953-9.
1993: S Klages; D Adam; E Eiseman; J Fargnoli; S M Dymecki; Stephen Desiderio; J B Bolen
Molecular cloning and analysis of cDNA encoding the murine c-yes tyrosine protein kinase.
Oncogene 1993;8(3):713-9.
1993: Stephen Desiderio
Human genetics. Becoming B cells.
Nature 1993;361(6409):202-3.
1992: Janet D Siliciano; T A Morrow; Stephen Desiderio
itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11194-8.
1992: K C Garcia; Stephen Desiderio; Pierre M Ronco; Pierre J Verroust; Mario Amzel
Recognition of angiotensin II: antibodies at different levels of an idiotypic network are superimposable.
Science (New York, N.Y.) 1992;257(5069):528-31.
1992: Stephen Desiderio
B-cell activation.
Current opinion in immunology 1992;4(3):252-6.
1992: S M Dymecki; P Zwollo; K Zeller; Francis P Kuhajda; Stephen Desiderio
Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk.
The Journal of biological chemistry 1992;267(7):4815-23.
1991: R B Wilson; M Kiledjian; Chun-Pyn Shen; Robert Benezra; P Zwollo; S M Dymecki; Stephen Desiderio; Tom Kadesch
Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development.
Molecular and cellular biology 1991;11(12):6185-91.
1991: Christine A Kozak; S M Dymecki; John E Niederhuber; Stephen Desiderio
Genetic mapping of the gene for a novel tyrosine kinase, Blk, to mouse chromosome 14.
Genomics 1991;9(4):762-4.
1991: A Alessandrini; Stephen Desiderio
Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation.
Molecular and cellular biology 1991;11(4):2096-107.
1990: S M Dymecki; John E Niederhuber; Stephen Desiderio
Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells.
Science (New York, N.Y.) 1990;247(4940):332-6.
1989: Min Li; E Morzycka-Wroblewska; Stephen Desiderio
NBP, a protein that specifically binds an enhancer of immunoglobulin gene rearrangement: purification and characterization.
Genes & development 1989;3(11):1801-13.
1988: E Morzycka-Wroblewska; F E Lee; Stephen Desiderio
Unusual immunoglobulin gene rearrangement leads to replacement of recombinational signal sequences.
Science (New York, N.Y.) 1988;242(4876):261-3.
1988: Stephen Desiderio; K R Wolff
Rearrangement of exogenous immunoglobulin VH and DJH gene segments after retroviral transduction into immature lymphoid cell lines.
The Journal of experimental medicine 1988;167(2):372-88.
1987: Brian Halligan; Stephen Desiderio
Identification of a DNA binding protein that recognizes the nonamer recombinational signal sequence of immunoglobulin genes.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(20):7019-23.
1987: A Alessandrini; J H Pierce; David Baltimore; Stephen Desiderio
Continuing rearrangement of immunoglobulin and T-cell receptor genes in a Ha-ras-transformed lymphoid progenitor cell line.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(7):1799-803.
1984: Stephen Desiderio; G D Yancopoulos; M Paskind; E Thomas; M A Boss; N Landau; F W Alt; David Baltimore
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells.
Nature 1984;311(5988):752-5.
1984: G D Yancopoulos; Stephen Desiderio; M Paskind; J F Kearney; David Baltimore; F W Alt
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines.
Nature 1984;311(5988):727-33.
1984: Stephen Desiderio; David Baltimore
Double-stranded cleavage by cell extracts near recombinational signal sequences of immunoglobulin genes.
Nature 1984;308(5962):860-2.
1981: Stephen Desiderio; Thomas J Kelly
Structure of the linkage between adenovirus DNA and the 55,000 molecular weight terminal protein.
Journal of molecular biology 1981;145(2):319-37.
1980: M D Challberg; Stephen Desiderio; Thomas J Kelly
Adenovirus DNA replication in vitro: characterization of a protein covalently linked to nascent DNA strands.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(9):5105-9.
1978: Stephen Desiderio; S Boyer
Arber, Smith and Nathans: Nobel Laureates in medicine and physiology, 1978.
The Johns Hopkins medical journal 1978;143(5):ix-x.