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John DeSimone

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Mark L Dewis; Meng Cui; John A DeSimone; Xuanyu Meng; Shobha Mummalaneni; Tam-Hao T Phan; ZuoJun Ren; Mee-Ra Rhyu; Vijay Lyall
N-geranyl cyclopropyl-carboximide modulates salty and umami taste in humans and animal models.
John A DeSimone; Adam Drewnowski; Gary K Beauchamp; Guy H Johnson
Sodium in the food supply: challenges and opportunities.
John A DeSimone; Shobha Mummalaneni; Tam-Hao T Phan; Zuojun Ren; Vijay Lyall
Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to bitter, sweet, and umami taste stimuli.

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2013: Mark L Dewis; Meng Cui; John A DeSimone; Xuanyu Meng; Shobha Mummalaneni; Tam-Hao T Phan; ZuoJun Ren; Mee-Ra Rhyu; Vijay Lyall
N-geranyl cyclopropyl-carboximide modulates salty and umami taste in humans and animal models.
Journal of neurophysiology 2013;109(4):1078-90.
2013: John A DeSimone; Adam Drewnowski; Gary K Beauchamp; Guy H Johnson
Sodium in the food supply: challenges and opportunities.
Nutrition reviews 2013;71(1):52-9.
2012: John A DeSimone; Shobha Mummalaneni; Tam-Hao T Phan; Zuojun Ren; Vijay Lyall
Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to bitter, sweet, and umami taste stimuli.
Journal of neurophysiology 2012;108(12):3221-32.
2012: John A DeSimone; Gerard L Heck; Shobha Mummalaneni; Tam-Hao T Phan; Zuojun Ren; Vijay Lyall
Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to salty and sour taste stimuli.
Journal of neurophysiology 2012;108(12):3206-20.
2011: Jamison Coleman; John A DeSimone; Tadayoshi Katsumata; Sunila Mahavadi; Pamela Melone; Shobha Mummalaneni; Karnam S Murthy; Tam-Hao T Phan; Zuojun Ren; Ashley Williams; Huiping Zhou; Vijay Lyall
Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats.
Journal of neurophysiology 2011;106(5):2606-21.
2011: John A DeSimone; Tam-Hao T Phan; Gerard L Heck; Zuojun Ren; Jamison Coleman; Shobha Mummalaneni; Pamela Melone; Vijay Lyall
Involvement of NADPH-dependent and cAMP-PKA sensitive H+ channels in the chorda tympani nerve responses to strong acids.
Chemical senses 2011;36(4):389-403.
2011: Gregory R Sturz; Tam-Hao T Phan; Shobha Mummalaneni; Zuojun Ren; John A DeSimone; Vijay Lyall
The K+-H+ exchanger, nigericin, modulates taste cell pH and chorda tympani taste nerve responses to acidic stimuli.
Chemical senses 2011;36(4):375-88.
2010: Vijay Lyall; Tam-Hao T Phan; ZuoJun Ren; Shobha Mummalaneni; Pamela Melone; Sunila Mahavadi; Karnam S Murthy; John A DeSimone
Regulation of the putative TRPV1t salt taste receptor by phosphatidylinositol 4,5-bisphosphate.
Journal of neurophysiology 2010;103(3):1337-49.
2009: Vijay Lyall; Tam-Hao T Phan; Shobha Mummalaneni; Pamela Melone; Sunila Mahavadi; Karnam S Murthy; John A DeSimone
Regulation of the benzamil-insensitive salt taste receptor by intracellular Ca2+, protein kinase C, and calcineurin.
Journal of neurophysiology 2009;102(3):1591-605.
2008: Tadayoshi Katsumata; Hiroko Nakakuki; Chikara Tokunaga; Noboru Fujii; Makoto Egi; Tam-Hao T Phan; Shobha Mummalaneni; John A DeSimone; Vijay Lyall
Effect of Maillard reacted peptides on human salt taste and the amiloride-insensitive salt taste receptor (TRPV1t).
Chemical senses 2008;33(7):665-80.
2007: Vijay Lyall; Tam-Hao T Phan; Shobha Mummalaneni; Mahdis Mansouri; Gerard L Heck; Gerd Kobal; John A DeSimone
Effect of nicotine on chorda tympani responses to salty and sour stimuli.
Journal of neurophysiology 2007;98(3):1662-74.
2007: Yada Treesukosol; Vijay Lyall; Gerard L Heck; John A DeSimone; Alan C Spector
A psychophysical and electrophysiological analysis of salt taste in Trpv1 null mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(5):R1799-809.
2006: John A DeSimone; Vijay Lyall
Taste receptors in the gastrointestinal tract III. Salty and sour taste: sensing of sodium and protons by the tongue.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(6):G1005-10.
2006: Vijay Lyall; Hampton Pasley; Tam-Hao T Phan; Shobha Mummalaneni; Gerard L Heck; Anna K Vinnikova; John A DeSimone
Intracellular pH modulates taste receptor cell volume and the phasic part of the chorda tympani response to acids.
The Journal of general physiology 2006;127(1):15-34.
2005: Vijay Lyall; Gerard L Heck; Tam-Hao T Phan; Shobha Mummalaneni; Shahbaz A Malik; Anna K Vinnikova; John A DeSimone
Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. II. Effect on chorda tympani salt responses.
The Journal of general physiology 2005;125(6):587-600.
2005: Vijay Lyall; Gerard L Heck; Tam-Hao T Phan; Shobha Mummalaneni; Shahbaz A Malik; Anna K Vinnikova; John A DeSimone
Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. I. Effect on TRC volume and Na+ flux.
The Journal of general physiology 2005;125(6):569-85.
2005: Vijay Lyall; Gerard L Heck; Anna K Vinnikova; Shobha Ghosh; Tam-Hao T Phan; John A DeSimone
A novel vanilloid receptor-1 (VR-1) variant mammalian salt taste receptor.
Chemical senses 2005;30 Suppl 1():i42-3.
2004: Vijay Lyall; Gerard L Heck; Anna K Vinnikova; Shobha Ghosh; Tam-Hao T Phan; Rammy I Alam; Oneal F Russell; Shahbaz A Malik; John W Bigbee; John A DeSimone
The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant.
The Journal of physiology 2004;558(Pt 1):147-59.
2004: Vijay Lyall; Rammy I Alam; Shahbaz A Malik; Tam-Hao T Phan; Anna K Vinnikova; Gerard L Heck; John A DeSimone
Basolateral Na+-H+ exchanger-1 in rat taste receptor cells is involved in neural adaptation to acidic stimuli.
The Journal of physiology 2004;556(Pt 1):159-73.
2004: Anna K Vinnikova; Rammy I Alam; Shahbaz A Malik; Glenn L Ereso; George M Feldman; John M McCarty; Mark A Knepper; Gerard L Heck; John A DeSimone; Vijay Lyall
Na+-H+ exchange activity in taste receptor cells.
Journal of neurophysiology 2004;91(3):1297-313.
2003: George M Feldman; Andras Mogyorosi; Gerard L Heck; John A DeSimone; Cecily R Santos; Rebecca A Clary; Vijay Lyall
Salt-evoked lingual surface potential in humans.
Journal of neurophysiology 2003;90(3):2060-4.
2002: Vijay Lyall; Rammy I Alam; Tam-Hao T Phan; Oneal F Russell; Shahbaz A Malik; Gerard L Heck; John A DeSimone
Modulation of rat chorda tympani NaCl responses and intracellular Na+ activity in polarized taste receptor cells by pH.
The Journal of general physiology 2002;120(6):793-815.
2002: Vijay Lyall; Rammy I Alam; Tam-Hao T Phan; Duy Q Phan; Gerard L Heck; John A DeSimone
Excitation and adaptation in the detection of hydrogen ions by taste receptor cells: a role for cAMP and Ca(2+).
Journal of neurophysiology 2002;87(1):399-408.
2001: John A DeSimone; Vijay Lyall; Gerard L Heck; George M Feldman
Acid detection by taste receptor cells.
Respiration physiology 2001;129(1-2):231-45.
2001: John A DeSimone; Vijay Lyall; Gerard L Heck; Tam-Hao T Phan; Rammy I Alam; George M Feldman; R M Buch
A novel pharmacological probe links the amiloride-insensitive NaCl, KCl, and NH(4)Cl chorda tympani taste responses.
Journal of neurophysiology 2001;86(5):2638-41.
2001: Vijay Lyall; Rammy I Alam; D Q Phan; Glenn L Ereso; Tam-Hao T Phan; Shahbaz A Malik; M H Montrose; Shaoyou Chu; Gerard L Heck; George M Feldman; John A DeSimone
Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction.
American journal of physiology. Cell physiology 2001;281(3):C1005-13.
2000: S J Hendricks; RE Stewart; Gerard L Heck; John A DeSimone; D L Hill
Development of rat chorda tympani sodium responses: evidence for age-dependent changes in global amiloride-sensitive Na(+) channel kinetics.
Journal of neurophysiology 2000;84(3):1531-44.
1999: Vijay Lyall; Gerard L Heck; John A DeSimone; George M Feldman
Effects of osmolarity on taste receptor cell size and function.
The American journal of physiology 1999;277(4 Pt 1):C800-13.
1998: RE Stewart; Vijay Lyall; George M Feldman; Gerard L Heck; John A DeSimone
Acid-induced responses in hamster chorda tympani and intracellular pH tracking by taste receptor cells.
The American journal of physiology 1998;275(1 Pt 1):C227-38.
1998: M A Kloub; Gerard L Heck; John A DeSimone
Self-inhibition in Ca2+ -evoked taste responses: a novel tool for functional dissection of salt taste transduction mechanisms.
Journal of neurophysiology 1998;79(2):911-21.
1997: Vijay Lyall; George M Feldman; Gerard L Heck; John A DeSimone
Effects of extracellular pH, PCO2, and HCO3- on intracellular pH in isolated rat taste buds.
The American journal of physiology 1997;273(3 Pt 1):C1008-19.
1997: M A Kloub; Gerard L Heck; John A DeSimone
Chorda tympani responses under lingual voltage clamp: implications for NH4 salt taste transduction.
Journal of neurophysiology 1997;77(3):1393-406.
1997: RE Stewart; John A DeSimone; D L Hill
New perspectives in a gustatory physiology: transduction, development, and plasticity.
The American journal of physiology 1997;272(1 Pt 1):C1-26.
1996: R E Stewart; Gerard L Heck; John A DeSimone
Taste-mixture suppression: functional dissection of cellular and paracellular origins.
Journal of neurophysiology 1996;75(5):2124-8.
1995: John A DeSimone; E M Callaham; Gerard L Heck
Chorda tympani taste response of rat to hydrochloric acid subject to voltage-clamped lingual receptive field.
The American journal of physiology 1995;268(5 Pt 1):C1295-300.
1994: Q Ye; Gerard L Heck; John A DeSimone
Effects of voltage perturbation of the lingual receptive field on chorda tympani responses to Na+ and K+ salts in the rat: implications for gustatory transduction.
The Journal of general physiology 1994;104(5):885-907.
1993: Q Ye; R E Stewart; Gerard L Heck; D L Hill; John A DeSimone
Dietary Na(+)-restriction prevents development of functional Na+ channels in taste cell apical membranes: proof by in vivo membrane voltage perturbation.
Journal of neurophysiology 1993;70(4):1713-6.
1993: Q Ye; Gerard L Heck; John A DeSimone
Voltage dependence of the rat chorda tympani response to Na+ salts: implications for the functional organization of taste receptor cells.
Journal of neurophysiology 1993;70(1):167-78.
1993: John A DeSimone; Q Ye; Gerard L Heck
Ion pathways in the taste bud and their significance for transduction.
Ciba Foundation symposium 1993;179():218-29; discussion 229-34.
1991: Q Ye; Gerard L Heck; John A DeSimone
The anion paradox in sodium taste reception: resolution by voltage-clamp studies.
Science (New York, N.Y.) 1991;254(5032):724-6.
1991: John A DeSimone
Transduction in taste receptors.
Nutrition (Burbank, Los Angeles County, Calif.) 1991;7(2):146-9.
1989: Gerard L Heck; K C Persaud; John A DeSimone
Direct measurement of translingual epithelial NaCl and KCl currents during the chorda tympani taste response.
Biophysical journal 1989;55(5):843-57.
1988: K C Persaud; Gerard L Heck; S K DeSimone; Thomas V Getchell; John A DeSimone
Ion transport across the frog olfactory mucosa: the action of cyclic nucleotides on the basal and odorant-stimulated states.
Biochimica et biophysica acta 1988;944(1):49-62.
1988: S Mierson; S K DeSimone; Gerard L Heck; John A DeSimone
Sugar-activated ion transport in canine lingual epithelium. Implications for sugar taste transduction.
The Journal of general physiology 1988;92(1):87-111.
1988: S Mierson; M E Welter; C Gennings; John A DeSimone
Lingual epithelium of spontaneously hypertensive rats has decreased short-circuit current in response to NaCl.
Hypertension 1988;11(6 Pt 1):519-22.
1987: K C Persaud; John A DeSimone; Marilyn L Getchell; Gerard L Heck; Thomas V Getchell
Ion transport across the frog olfactory mucosa: the basal and odorant-stimulated states.
Biochimica et biophysica acta 1987;902(1):65-79.
1987: Marilyn L Getchell; B Zielinski; John A DeSimone; Thomas V Getchell
Odorant stimulation of secretory and neural processes in the salamander olfactory mucosa.
Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 1987;160(2):155-68.
1986: T U Biber; John A DeSimone; K Drewnowska
Potential dependence of unidirectional chloride fluxes across isolated frog skin.
Biochimica et biophysica acta 1986;862(1):27-38.
1985: S Mierson; Gerard L Heck; S K DeSimone; T U Biber; John A DeSimone
The identity of the current carriers in canine lingual epithelium in vitro.
Biochimica et biophysica acta 1985;816(2):283-93.
1984: John A DeSimone; Gerard L Heck; S Mierson; S K Desimone
The active ion transport properties of canine lingual epithelia in vitro. Implications for gustatory transduction.
The Journal of general physiology 1984;83(5):633-56.
1984: Gerard L Heck; S Mierson; John A DeSimone
Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway.
Science (New York, N.Y.) 1984;223(4634):403-5.
1981: John A DeSimone; Gerard L Heck; S K DeSimone
Active ion transport in dog tongue: a possible role in taste.
Science (New York, N.Y.) 1981;214(4524):1039-41.
1980: Thomas V Getchell; Gerard L Heck; John A DeSimone; S Price
The location of olfactory receptor sites. Inferences from latency measurements.
Biophysical journal 1980;29(3):397-411.
1980: T U Biber; T L Mullen; John A DeSimone
Effect of FeCl3 on ion transport in isolated frog skin.
The Journal of membrane biology 1980;52(2):133-9.