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Mercedes Amat

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Mercedes Amat; Roberto Ballette; Maria Pérez; Stefano Proto; Joan Bosch
First enantioselective synthesis of tetracyclic intermediates en route to madangamine D.
Mercedes Amat; Pedro Florindo; Elies Molins; Maria Pérez; Carlos Ramos; Maria M M Santos; Joan Bosch
Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline.
Mercedes Amat; Carmen Escolano; Elies Molins; Vladislav Semak; Joan Bosch
Enantioselective, protecting group-free synthesis of 1S-ethyl-4-substituted quinolizidines.

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All Publications

2013: Mercedes Amat; Roberto Ballette; Maria Pérez; Stefano Proto; Joan Bosch
First enantioselective synthesis of tetracyclic intermediates en route to madangamine D.
Chemical communications (Cambridge, England) 2013;49(30):3149-51.
2013: Mercedes Amat; Pedro Florindo; Elies Molins; Maria Pérez; Carlos Ramos; Maria M M Santos; Joan Bosch
Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline.
Chemical communications (Cambridge, England) 2013;49(19):1954-6.
2012: Mercedes Amat; Carmen Escolano; Elies Molins; Vladislav Semak; Joan Bosch
Enantioselective, protecting group-free synthesis of 1S-ethyl-4-substituted quinolizidines.
Organic & biomolecular chemistry 2012;10(34):6866-75.
2012: Stefano Proto; Federica Romagnoli; Mercedes Amat; Roberto Ballette; Andrea Mancinelli; Maria Pérez; Joan Bosch
Model studies on the synthesis of madangamine alkaloids. Assembly of the macrocyclic rings.
Organic letters 2012;14(15):3916-9.
2012: Joan Bosch; Antonia M Gómez; Rosa Griera; Marta Écija; Jordi Bachs; Mercedes Amat
Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer.
The Journal of organic chemistry 2012;77(14):6340-4.
2012: Ignasi Mata; Elies Molins; Mercedes Amat; Núria Llor; Begoña Checa
C-H···X (X = O, N or π) interactions in benzyl carbamate.
Acta crystallographica. Section C, Crystal structure communications 2012;68(Pt 3):o114-8.
2011: Anna Vallverdú-Queralt; Alexander Medina-Remón; Mercedes Amat; Isidre Casals-Ribes; Rosa M Lamuela-Raventós
A metabolomic approach differentiates between conventional and organic ketchups.
Journal of agricultural and food chemistry 2011;59(21):11703-10.
2011: Carlos Arróniz; Joan Bosch; Carmen Escolano; F Javier Luque; Mercedes Amat
First asymmetric cascade reaction catalysed by chiral primary aminoalcohols.
Organic & biomolecular chemistry 2011;9(14):5079-85.
2011: Mercedes Amat; Maria Pérez; Joan Bosch
Stereoselective conjugate addition reactions to phenylglycinol-derived, unsaturated oxazolopiperidone lactams.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(28):7724-32.
2011: Mercedes Amat; Carlos Arróniz; Elies Molins; Carmen Escolano; Joan Bosch
Highly stereoselective double (R)-phenylglycinol-induced cyclocondensation reactions of symmetric aryl bis(oxoacids).
Organic & biomolecular chemistry 2011;9(7):2175-84.
2011: Mercedes Amat; Núria Llor; Rosa Griera; Maria Pérez; Joan Bosch
Enantioselective synthesis of alkaloids from phenylglycinol-derived lactams.
Natural product communications 2011;6(4):515-26.
2010: Mercedes Amat; Maria Pérez; Stefano Proto; Teresa Gatti; Joan Bosch
First enantioselective synthesis of the diazatricyclic core of madangamine alkaloids.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(31):9438-41.
2010: Mercedes Amat; Robert Fabregat; Rosa Griera; Pedro Florindo; Elies Molins; Joan Bosch
Biomimetic construction of the hydroquinoline ring system. Diastereodivergent enantioselective synthesis of 2,5-disubstituted cis-decahydroquinolines.
The Journal of organic chemistry 2010;75(11):3797-805.
2010: Mercedes Amat; Núria Llor; Begoña Checa; Elies Molins; Joan Bosch
A synthetic approach to ervatamine-silicine alkaloids. Enantioselective total synthesis of (-)-16-episilicine.
The Journal of organic chemistry 2010;75(1):178-89.
2009: Mercedes Amat; Elisa Brunaccini; Begoña Checa; Maria Pérez; Núria Llor; Joan Bosch
An unexpected oxidation in the generation of cyclopenta[c]piperidines by ring-closing metathesis.
Organic letters 2009;11(19):4370-3.
2009: Mercedes Amat; Begoña Checa; Núria Llor; Elies Molins; Joan Bosch
Enantioselective total synthesis of the indole alkaloid 16-episilicine.
Chemical communications (Cambridge, England) 2009;(20):2935-7.
2009: Mercedes Amat; Robert Fabregat; Rosa Griera; Joan Bosch
A general synthetic route to enantiopure 5-substituted cis-decahydroquinolines.
The Journal of organic chemistry 2009;74(4):1794-7.
2009: Mercedes Amat; Arantxa Gómez-Esqué; Carmen Escolano; Maria M M Santos; Elies Molins; Joan Bosch
Enantioselective formal synthesis of (+)-dihydrocorynantheine and (-)-dihydrocorynantheol.
The Journal of organic chemistry 2009;74(3):1205-11.
2008: Ignacio Soteras; Oscar Lozano; Carmen Escolano; Modesto Orozco; Mercedes Amat; Joan Bosch; F Javier Luque
Structure-directed reversion in the pi-facial stereoselective alkylation of chiral bicyclic lactams.
The Journal of organic chemistry 2008;73(19):7756-63.
2008: Mercedes Amat; Maria Pérez; Annamaria T Minaglia; Joan Bosch
An enantioselective synthetic route to cis-2,4-disubstituted and 2,4-bridged piperidines.
The Journal of organic chemistry 2008;73(17):6920-3.
2008: Mercedes Amat; Rosa Griera; Robert Fabregat; Elies Molins; Joan Bosch
A biomimetic enantioselective approach to the decahydroquinoline class of dendrobatid alkaloids.
Angewandte Chemie (International ed. in English) 2008;47(18):3348-51.
2007: Mercedes Amat; Maria M M Santos; Antonia M Gómez; Danica Jokic; Elies Molins; Joan Bosch
Enantioselective spirocyclizations from tryptophanol-derived oxazolopiperidone lactams.
Organic letters 2007;9(15):2907-10.
2007: Mercedes Amat; Maria M M Santos; Oriol Bassas; Núria Llor; Carmen Escolano; Arantxa Gómez-Esqué; Elies Molins; Steven M Allin; Vickie McKee; Joan Bosch
Straightforward methodology for the enantioselective synthesis of benzo[a]- and indolo[2,3-a]quinolizidines.
The Journal of organic chemistry 2007;72(14):5193-201.
2007: Mercedes Amat; Oscar Lozano; Carmen Escolano; Elies Molins; Joan Bosch
Enantioselective synthesis of 3,3-disubstituted piperidine derivatives by enolate dialkylation of phenylglycinol-derived oxazolopiperidone lactams.
The Journal of organic chemistry 2007;72(12):4431-9.
2006: Carmen Escolano; Mercedes Amat; Joan Bosch
Chiral oxazolopiperidone lactams: versatile intermediates for the enantioselective synthesis of piperidine-containing natural products.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(32):8198-207.
2006: Mercedes Amat; Oriol Bassas; Núria Llor; Margalida Cantó; Maria Pérez; Elies Molins; Joan Bosch
Dynamic kinetic resolution and desymmetrization processes: a straightforward methodology for the enantioselective synthesis of piperidines.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(30):7872-81.
2006: Ignacio Soteras; Oscar Lozano; Arantxa Gómez-Esqué; Carmen Escolano; Modesto Orozco; Mercedes Amat; Joan Bosch; F Javier Luque
On the origin of the stereoselectivity in the alkylation of oxazolopiperidone enolates.
Journal of the American Chemical Society 2006;128(20):6581-8.
2006: Mercedes Amat; Carmen Escolano; Oscar Lozano; Arantxa Gómez-Esqué; Rosa Griera; Elies Molins; Joan Bosch
Alkylation of phenylglycinol-derived oxazolopiperidone lactams. Enantioselective synthesis of beta-substituted piperidines.
The Journal of organic chemistry 2006;71(10):3804-15.
2006: Rosa Griera; Carme Cantos-Llopart; Mercedes Amat; Joan Bosch; Juan-C Del Castillo; Joan Huguet
New potential antibacterials: a synthetic route to N-aryloxazolidinone/3-aryltetrahydroisoquinoline hybrids.
Bioorganic & medicinal chemistry letters 2006;16(3):529-31.
2005: Mercedes Amat; Maria Pérez; Annamaria T Minaglia; Núria Casamitjana; Joan Bosch
An enantioselective entry to cis-perhydroisoquinolines.
Organic letters 2005;7(17):3653-6.
2005: Oriol Bassas; Núria Llor; Maria M M Santos; Rosa Griera; Elies Molins; Mercedes Amat; Joan Bosch
Biogenetically inspired enantioselective approach to Indolo[2,3-a]- and benzo[a]quinolizidine alkaloids from a synthetic equivalent of secologanin.
Organic letters 2005;7(14):2817-20.
2005: Rosa Griera; Carme Cantos-Llopart; Mercedes Amat; Joan Bosch; Juan-C Del Castillo; Joan Huguet
A synthetic route to a novel type of conformationally constrained N-aryloxazolidinones.
Bioorganic & medicinal chemistry letters 2005;15(10):2515-7.
2005: Mercedes Amat; Oriol Bassas; Miquel A Pericàs; Mireia Pastó; Joan Bosch
Highly enantioselective dynamic kinetic resolution and desymmetrization processes by cyclocondensation of chiral aminoalcohols with racemic or prochiral delta-oxoacid derivatives.
Chemical communications (Cambridge, England) 2005;(10):1327-9.
2004: Mercedes Amat; Maria Pérez; Núria Llor; Carmen Escolano; F Javier Luque; Elies Molins; Joan Bosch
Conjugate additions to phenylglycinol-derived unsaturated delta-lactams. Enantioselective synthesis of uleine alkaloids.
The Journal of organic chemistry 2004;69(25):8681-93.
2004: Mercedes Amat; Maria Pérez; Núria Llor; Marisa Martinelli; Elies Molins; Joan Bosch
Enantioselective formal synthesis of uleine alkaloids from phenylglycinol-derived bicyclic lactams.
Chemical communications (Cambridge, England) 2004;(14):1602-3.
2003: Mercedes Amat; Carmen Escolano; Oscar Lozano; Núria Llor; Joan Bosch
Enantioselective synthesis of cis- and trans-3,5-disubstituted piperidines. Synthesis of 20S- and 20R-dihydrocleavamine.
Organic letters 2003;5(17):3139-42.
2003: Mercedes Amat; Núria Llor; José Hidalgo; Carmen Escolano; Joan Bosch
Enantioselective synthesis of piperidine, indolizidine, and quinolizidine alkaloids from a phenylglycinol-derived delta-lactam.
The Journal of organic chemistry 2003;68(5):1919-28.
2002: Mercedes Amat; Maria Pérez; Núria Llor; Joan Bosch
Stereodivergent synthesis of enantiopure cis- and trans-3-Ethyl-4-piperidineacetates.
Organic letters 2002;4(16):2787-90.
2002: Mercedes Amat; Margalida Cantó; Núria Llor; Carmen Escolano; Elies Molins; Enrique Espinosa; Joan Bosch
Dynamic kinetic resolution of racemic gamma-aryl-delta-oxoesters. Enantioselective synthesis of 3-arylpiperidines.
The Journal of organic chemistry 2002;67(15):5343-51.
2002: Mercedes Amat; Margalida Cantó; Núria Llor; Joan Bosch
Enantioselective synthesis of 2-arylpiperidines from chiral lactams. A concise synthesis of (-)-anabasine.
Chemical communications (Cambridge, England) 2002;(5):526-7.
2002: Mercedes Amat; Margalida Cantó; Núria Llor; Viviana Ponzo; Maria Pérez; Joan Bosch
Dynamic kinetic resolution and desymmetrization of enantiotopic groups by cyclodehydration of racemic or prochiral delta-oxoesters with (R)-phenylglycinol: enantioselective synthesis of piperidines.
Angewandte Chemie (International ed. in English) 2002;41(2):335-8.
2001: Mercedes Amat; Núria Llor; M Huguet; Elies Molins; Enrique Espinosa; Joan Bosch
Unprecedented oxidation of a phenylglycinol-derived 2-pyridone: enantioselective synthesis of polyhydroxypiperidines.
Organic letters 2001;3(21):3257-60.
2001: Mercedes Amat; Maria Pérez; Núria Llor; Joan Bosch; E Lago; Elies Molins
Conjugate addition of organocuprates to chiral bicyclic delta-lactams. Enantioselective synthesis of cis-3,4-disubstituted and 3,4,5-trisubstituted piperidines.
Organic letters 2001;3(4):611-4.
2000: Mercedes Amat; Joan Bosch; J Hidalgo; Margalida Cantó; Maria Pérez; Núria Llor; Elies Molins; Carlos Miravitlles; Modesto Orozco; J Luque
Synthesis of enantiopure trans-3,4-disubstituted piperidines. An enantiodivergent synthesis of (+)- and (-)-paroxetine.
The Journal of organic chemistry 2000;65(10):3074-84.