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Laurent Abi-Rached

Research Profile

Chemicals & Drugs

Phenomena

Evolution, Molecular

Anatomy

Killer Cells, Natural

Concepts & Ideas

Living Beings

Physiology

Genes & Molecular Sequences

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Publications

TOP 3
Hugo G Hilton; Achim K Moesta; Paul J Norman; Anastazia M Older Aguilar; Laurent Abi-Rached; Katharina Fleischhauer; Thorsten Graef; Lisbeth A Guethlein; Luca Vago; Peter Parham
Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.
Peter Parham; Paul J Norman; Laurent Abi-Rached; Lisbeth A Guethlein
Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules.
Peter Parham; Laurent Abi-Rached; H G Hilton; Paul J Norman; Lisbeth A Guethlein
Review: Immunogenetics of human placentation.

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All Publications

2012: Hugo G Hilton; Achim K Moesta; Paul J Norman; Anastazia M Older Aguilar; Laurent Abi-Rached; Katharina Fleischhauer; Thorsten Graef; Lisbeth A Guethlein; Luca Vago; Peter Parham
Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(3):1418-30.
2012: Peter Parham; Paul J Norman; Laurent Abi-Rached; Lisbeth A Guethlein
Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2012;367(1590):800-11.
2012: Peter Parham; Laurent Abi-Rached; H G Hilton; Paul J Norman; Lisbeth A Guethlein
Review: Immunogenetics of human placentation.
Placenta 2012;33 Suppl():S71-80.
2011: Laurent Abi-Rached; Farbod Babrzadeh; Meral Beksac; Mary Carrington; Klara Dalva; Baback Gharizadeh; Loren Gragert; Richard E Green; Lisbeth A Guethlein; Matthew J Jobin; Joshua Kimani; Subhash Kulkarni; Ann-Margaret Little; Ma Luo; Martin Maiers; Steven G E Marsh; Alasdair McWhinnie; Derek Middleton; Paul J Norman; Francis A Plummer; Raja Rajalingam; Sofia Tavoularis; Peter Parham
The shaping of modern human immune systems by multiregional admixture with archaic humans.
Science (New York, N.Y.) 2011;334(6052):89-94.
2011: Anastazia M Older Aguilar; Laurent Abi-Rached; Lisbeth A Guethlein; Peter Parham
Natural variation at position 45 in the D1 domain of lineage III killer cell immunoglobulin-like receptors (KIR) has major effects on the avidity and specificity for MHC class I.
Immunogenetics 2011;63(8):543-7.
2011: Peter Parham; Paul J Norman; Laurent Abi-Rached; Lisbeth A Guethlein
Variable NK cell receptors exemplified by human KIR3DL1/S1.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):11-9.
2011: Michael Gleimer; Angela R Wahl; Heather D Hickman; Laurent Abi-Rached; Paul J Norman; Lisbeth A Guethlein; John Hammond; Monia Draghi; Erin J Adams; Sean Juo; Roxana Jalili; Baback Gharizadeh; Mostafa Ronaghi; K Christopher Garcia; William H Hildebrand; Peter Parham
Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1575-88.
2010: Laurent Abi-Rached; Achim K Moesta; Raja Rajalingam; Lisbeth A Guethlein; Peter Parham
Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells.
PLoS genetics 2010;6(11):e1001192.
2010: Achim K Moesta; Thorsten Graef; Laurent Abi-Rached; Anastazia M Older Aguilar; Lisbeth A Guethlein; Peter Parham
Humans differ from other hominids in lacking an activating NK cell receptor that recognizes the C1 epitope of MHC class I.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):4233-7.
2010: Peter Parham; Laurent Abi-Rached; Lilit Matevosyan; Achim K Moesta; Paul J Norman; Anastazia M Older Aguilar; Lisbeth A Guethlein
Primate-specific regulation of natural killer cells.
Journal of medical primatology 2010;39(4):194-212.
2010: Laurent Abi-Rached; Heiner Kuhl; Christian Roos; Boudewijn ten Hallers; Baoli Zhu; Lucia Carbone; Pieter J de Jong; Alan R Mootnick; Florian Knaust; Richard Reinhardt; Peter Parham; Lutz Walter
A small, variable, and irregular killer cell Ig-like receptor locus accompanies the absence of MHC-C and MHC-G in gibbons.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1379-91.
2009: Ketevan Gendzekhadze; Paul J Norman; Laurent Abi-Rached; Thorsten Graef; Achim K Moesta; Zulay Layrisse; Peter Parham
Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(44):18692-7.
2009: Thorsten Graef; Achim K Moesta; Paul J Norman; Laurent Abi-Rached; Luca Vago; Anastazia M Older Aguilar; Michael Gleimer; John Hammond; Lisbeth A Guethlein; David A Bushnell; Philip J Robinson; Peter Parham
KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.
The Journal of experimental medicine 2009;206(11):2557-72.
2009: Achim K Moesta; Laurent Abi-Rached; Paul J Norman; Peter Parham
Chimpanzees use more varied receptors and ligands than humans for inhibitory killer cell Ig-like receptor recognition of the MHC-C1 and MHC-C2 epitopes.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3628-37.
2009: John Hammond; Lisbeth A Guethlein; Laurent Abi-Rached; Achim K Moesta; Peter Parham
Evolution and survival of marine carnivores did not require a diversity of killer cell Ig-like receptors or Ly49 NK cell receptors.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3618-27.
2008: Matthew Kirkham; Susan Nixon; Mark T Howes; Laurent Abi-Rached; Diane E Wakeham; Michael Hanzal-Bayer; Charles Ferguson; Michelle M Hill; Manuel Fernandez-Rojo; Deborah A Brown; John F Hancock; Frances M Brodsky; Robert Parton
Evolutionary analysis and molecular dissection of caveola biogenesis.
Journal of cell science 2008;121(Pt 12):2075-86.
2007: Lisbeth A Guethlein; Anastazia M Older Aguilar; Laurent Abi-Rached; Peter Parham
Evolution of killer cell Ig-like receptor (KIR) genes: definition of an orangutan KIR haplotype reveals expansion of lineage III KIR associated with the emergence of MHC-C.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):491-504.
2007: Laurent Abi-Rached; Kristel Dorighi; Paul J Norman; Makoto Yawata; Peter Parham
Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7943-54.
2007: Lisbeth A Guethlein; Laurent Abi-Rached; John Hammond; Peter Parham
The expanded cattle KIR genes are orthologous to the conserved single-copy KIR3DX1 gene of primates.
Immunogenetics 2007;59(6):517-22.
2006: Ketevan Gendzekhadze; Paul J Norman; Laurent Abi-Rached; Zulay Layrisse; Peter Parham
High KIR diversity in Amerindians is maintained using few gene-content haplotypes.
Immunogenetics 2006;58(5-6):474-80.
2005: Diane E Wakeham; Laurent Abi-Rached; Mhairi C Towler; Jeremy D Wilbur; Peter Parham; Frances M Brodsky
Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7209-14.
2005: Laurent Abi-Rached; Peter Parham
Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues.
The Journal of experimental medicine 2005;201(8):1319-32.
2005: Jennifer G Sambrook; Arman Bashirova; Sophie Palmer; Sarah Sims; John Trowsdale; Laurent Abi-Rached; Peter Parham; Mary Carrington; Stephan Beck
Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor (KIR) loci in primates.
Genome research 2005;15(1):25-35.
2004: Raja Rajalingam; Peter Parham; Laurent Abi-Rached
Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):356-69.
2003: Alexandre Vienne; Takashi Shiina; Laurent Abi-Rached; Etienne G J Danchin; Verane Vitiello; François Cartault; Hidetoshi Inoko; Pierre Pontarotti
Evolution of the proto-MHC ancestral region: more evidence for the plesiomorphic organisation of human chromosome 9q34 region.
Immunogenetics 2003;55(7):429-36.
2003: Alexandre Vienne; Jeffrey Rasmussen; Laurent Abi-Rached; Pierre Pontarotti; André Gilles
Systematic phylogenomic evidence of en bloc duplication of the ancestral 8p11.21-8p21.3-like region.
Molecular biology and evolution 2003;20(8):1290-8.
2003: Etienne G J Danchin; Laurent Abi-Rached; André Gilles; Pierre Pontarotti
Conservation of the MHC-like region throughout evolution.
Immunogenetics 2003;55(3):141-8.
2002: Laurent Abi-Rached; André Gilles; Takashi Shiina; Pierre Pontarotti; Hidetoshi Inoko
Evidence of en bloc duplication in vertebrate genomes.
Nature genetics 2002;31(1):100-5.
2002: Makoto Yawata; Nobuyo Yawata; Laurent Abi-Rached; Peter Parham
Variation within the human killer cell immunoglobulin-like receptor (KIR) gene family.
Critical reviews in immunology 2002;22(5-6):463-82.
1999: Laurent Abi-Rached; M F McDermott; Pierre Pontarotti
The MHC big bang.
Immunological reviews 1999;167():33-44.