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R Devos

Research Profile

Chemicals & Drugs

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TOP 3
Y Guisez; I Faché; L Arthur Campfield; FJ Smith; A Farid; G Plaetinck; José Van der Heyden; Jan Tavernier; W Fiers; P Burn; R Devos
Efficient secretion of biologically active recombinant OB protein (leptin) in Escherichia coli, purification from the periplasm and characterization.
R Devos; Y Guisez; José Van der Heyden; DW White; Michael Kalai; M Fountoulakis; G Plaetinck
Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding.
S A Verploegen; G Plaetinck; R Devos; José Van der Heyden; Y Guisez
A human leptin mutant induces weight gain in normal mice.

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All Publications

1998: Y Guisez; I Faché; L Arthur Campfield; FJ Smith; A Farid; G Plaetinck; José Van der Heyden; Jan Tavernier; W Fiers; P Burn; R Devos
Efficient secretion of biologically active recombinant OB protein (leptin) in Escherichia coli, purification from the periplasm and characterization.
Protein expression and purification 1998;12(2):249-58.
1997: R Devos; Y Guisez; José Van der Heyden; DW White; Michael Kalai; M Fountoulakis; G Plaetinck
Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding.
The Journal of biological chemistry 1997;272(29):18304-10.
1997: S A Verploegen; G Plaetinck; R Devos; José Van der Heyden; Y Guisez
A human leptin mutant induces weight gain in normal mice.
FEBS letters 1997;405(2):237-40.
1997: DW White; KK Kuropatwinski; R Devos; Heinz Baumann; Louis A Tartaglia
Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization.
The Journal of biological chemistry 1997;272(7):4065-71.
1996: L Arthur Campfield; FJ Smith; Y Guisez; R Devos; P Burn
OB protein: A peripheral signal linking adiposity and central neural networks.
Appetite 1996;26(3):302.
1996: R Devos; J G Richards; L Arthur Campfield; Louis A Tartaglia; Y Guisez; José Van der Heyden; J Travernier; G Plaetinck; P Burn
OB protein binds specifically to the choroid plexus of mice and rats.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5668-73.
1995: Louis A Tartaglia; Marlene Dembski; X Weng; N Deng; J Culpepper; R Devos; G J Richards; L Arthur Campfield; F T Clark; J Deeds; C Muir; S Sanker; A Moriarty; KJ Moore; John S Smutko; G G Mays; E A Wool; C A Monroe; R I Tepper
Identification and expression cloning of a leptin receptor, OB-R.
Cell 1995;83(7):1263-71.
1995: L Arthur Campfield; FJ Smith; Y Guisez; R Devos; P Burn
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks.
Science (New York, N.Y.) 1995;269(5223):546-9.
1995: S Cornelis; G Plaetinck; R Devos; José Van der Heyden; Jan Tavernier; C J Sanderson; Y Guisez; W Fiers
Detailed analysis of the IL-5-IL-5R alpha interaction: characterization of crucial residues on the ligand and the receptor.
The EMBO journal 1995;14(14):3395-402.
1995: S Cornelis; I Fache; José Van der Heyden; Y Guisez; Jan Tavernier; R Devos; W Fiers; G Plaetinck
Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction.
European journal of immunology 1995;25(7):1857-64.
1995: R Devos; G Plaetinck; S Cornelis; Y Guisez; José Van der Heyden; Jan Tavernier
Interleukin-5 and its receptor: a drug target for eosinophilia associated with chronic allergic disease.
Journal of leukocyte biology 1995;57(6):813-9.
1995: Jan Tavernier; T Tuypens; Annick Verhee; G Plaetinck; R Devos; José Van der Heyden; Y Guisez; Christian Oefner
Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5194-8.
1995: Jan Tavernier; S Cornelis; R Devos; Y Guisez; G Plaetinck; José Van der Heyden
Structure/function analysis of human interleukin 5 and its receptor.
Agents and actions. Supplements 1995;46():23-34.
1994: R Devos; Y Guisez; G Plaetinck; S Cornelis; Jan Tavernier; José Van der Heyden; L H Foley; J E Scheffler
Covalent modification of the interleukin-5 receptor by isothiazolones leads to inhibition of the binding of interleukin-5.
European journal of biochemistry / FEBS 1994;225(2):635-40.
1993: R Devos; Y Guisez; S Cornelis; Annick Verhee; José Van der Heyden; M Manneberg; H W Lahm; W Fiers; Jan Tavernier; G Plaetinck
Recombinant soluble human interleukin-5 (hIL-5) receptor molecules. Cross-linking and stoichiometry of binding to IL-5.
The Journal of biological chemistry 1993;268(9):6581-7.
1992: T Tuypens; G Plaetinck; E Baker; G Sutherland; G Brusselle; W Fiers; R Devos; Jan Tavernier
Organization and chromosomal localization of the human interleukin 5 receptor alpha-chain gene.
European cytokine network 1992;3(5):451-9.
1992: Jan Tavernier; T Tuypens; G Plaetinck; Annick Verhee; W Fiers; R Devos
Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):7041-5.
1991: José Van der Heyden; R Devos; G Plaetinck; I Fache; W Fiers; Jan Tavernier
Characterization of the murine IL-5 receptor complex with the use of a panel of monoclonal antibodies. Relationship to the murine IL-3 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(10):3413-8.
1991: Jan Tavernier; R Devos; S Cornelis; T Tuypens; José Van der Heyden; W Fiers; G Plaetinck
A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF.
Cell 1991;66(6):1175-84.
1991: R Devos; G Plaetinck; José Van der Heyden; S Cornelis; Joël Vandekerckhove; W Fiers; Jan Tavernier
Molecular basis of a high affinity murine interleukin-5 receptor.
The EMBO journal 1991;10(8):2133-7.
1991: R Devos; Joël Vandekerckhove; A Rolink; G Plaetinck; José Van der Heyden; W Fiers; Jan Tavernier
Amino acid sequence analysis of a mouse interleukin 5 receptor protein reveals homology with a mouse interleukin 3 receptor protein.
European journal of immunology 1991;21(5):1315-7.
1990: R Devos; Jan Tavernier; G Plaetinck; José Van der Heyden; A Rolink; W Fiers
Expression of the murine interleukin-5 receptor on Xenopus laevis oocytes.
Biochemical and biophysical research communications 1990;172(2):570-5.
1990: G Plaetinck; José Van der Heyden; Jan Tavernier; I Faché; T Tuypens; S Fischkoff; W Fiers; R Devos
Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells.
The Journal of experimental medicine 1990;172(3):683-91.
1989: Jan Tavernier; R Devos; José Van der Heyden; G Hauquier; R Bauden; I Fache; E Kawashima; Joël Vandekerckhove; R Contreras; W Fiers
Expression of human and murine interleukin-5 in eukaryotic systems.
DNA (Mary Ann Liebert, Inc.) 1989;8(7):491-501.
1989: B Jayaram; R Devos; Y Guisez; Walter Fiers
Purification of human interleukin-4 produced in Escherichia coli.
Gene 1989;79(2):345-54.
1988: Peter Vandenabeele; B Jayaram; R Devos; A Shaw; Walter Fiers
Interleukin 1 alpha acts as an autocrine growth factor for RPMI 1788, an Epstein-Barr virus-transformed human B cell line.
European journal of immunology 1988;18(7):1027-31.
1986: J H Mutsaers; J P Kamerling; R Devos; Y Guisez; W Fiers; J F Vliegenthart
Structural studies of the carbohydrate chains of human gamma-interferon.
European journal of biochemistry / FEBS 1986;156(3):651-4.
1986: Wim Degrave; G Simons; R Devos; G Plaetinck; Erik Remaut; Jan Tavernier; W Fiers
Cloning and structure of a mouse interleukin-2 chromosomal gene.
Molecular biology reports 1986;11(1):57-61.
1984: R Devos; G Plaetinck; W Fiers
Induction of cytolytic cells by pure recombinant human interleukin 2.
European journal of immunology 1984;14(11):1057-60.
1984: G Simons; Erik Remaut; B Allet; R Devos; W Fiers
High-level expression of human interferon gamma in Escherichia coli under control of the pL promoter of bacteriophage lambda.
Gene 1984;28(1):55-64.
1984: R Devos; C Opsomer; S J Scahill; J Van der Heyden; W Fiers
Purification of recombinant glycosylated human gamma interferon expressed in transformed Chinese hamster ovary cells.
Journal of interferon research 1984;4(4):461-8.
1983: S J Scahill; R Devos; J Van der Heyden; W Fiers
Expression and characterization of the product of a human immune interferon cDNA gene in Chinese hamster ovary cells.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(15):4654-8.
1983: R Devos; G Plaetinck; H Cheroutre; G Simons; Wim Degrave; Jan Tavernier; Erik Remaut; Walter Fiers
Molecular cloning of human interleukin 2 cDNA and its expression in E. coli.
Nucleic acids research 1983;11(13):4307-23.
1983: Wim Degrave; Jan Tavernier; F Duerinck; G Plaetinck; R Devos; Walter Fiers
Cloning and structure of the human interleukin 2 chromosomal gene.
The EMBO journal 1983;2(12):2349-53.
1982: Walter Fiers; Erik Remaut; R Devos; H Cheroutre; R Contreras; D Gheysen; Wim Degrave; P Stanssens; Jan Tavernier; Y Taya; J Content
The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1982;299(1094):29-38.
1982: R Devos; H Cheroutre; Y Taya; Wim Degrave; H Van Heuverswyn; Walter Fiers
Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells.
Nucleic acids research 1982;10(8):2487-501.
1982: Y Taya; R Devos; Jan Tavernier; H Cheroutre; G Engler; Walter Fiers
Cloning and structure of the human immune interferon-gamma chromosomal gene.
The EMBO journal 1982;1(8):953-8.
1982: R Devos; H Cheroutre; Y Taya; Walter Fiers
Isolation and characterization of IFN-gamma mRNA derived from mitogen-induced human splenocytes.
Journal of interferon research 1982;2(3):409-20.
1981: R Derynck; R Devos; Erik Remaut; E Saman; P Stanssens; Jan Tavernier; G Volckaert; J Content; E De Clercq; Walter Fiers
Isolation and characterization of a human fibroblast interferon gene and its expression in Escherichia coli.
Reviews of infectious diseases 1981;3(6):1186-95.
1981: R Fang; W Min Jou; D Huylebroeck; R Devos; Walter Fiers
Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin.
Cell 1981;25(2):315-23.
1981: L Van Rompuy; W Min Jou; D Huylebroeck; R Devos; Walter Fiers
Complete nucleotide sequence of the nucleoprotein gene from the human influenza strain A/PR/8/34 (HON1).
European journal of biochemistry / FEBS 1981;116(2):347-53.
1980: M Verhoeyen; R Fang; Willy Min Jou; R Devos; D Huylebroeck; E Saman; Walter Fiers
Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75.
Nature 1980;286(5775):771-6.
1980: Willy Min Jou; M Verhoeyen; R Devos; E Saman; R Fang; D Huylebroeck; Walter Fiers; G Threlfall; C Barber; N Carey; S Emtage
Complete structure of the hemagglutinin gene from the human influenza A/Victoria/3/75 (H3N2) strain as determined from cloned DNA.
Cell 1980;19(3):683-96.