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Mieke Dewerchin

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Chemicals & Drugs

Physiology

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Cells, Cultured

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TOP 3
Mieke Dewerchin; Peter Carmeliet
PlGF: a multitasking cytokine with disease-restricted activity.
Goedele Wallays; Zsuzsanna Callaerts-Vegh; Peter Carmeliet; Désiré Collen; Rudi D'Hooge; Florea Lupu; Lieve Moons; Dieter Nuyens; Robert Silasi-Mansat; Joris Souffreau; An Van Nuffelen; Mieke Dewerchin
Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
Tine Van Bergen; Sara Van de Veire; Evelien Vandewalle; Mieke Dewerchin; Lieve Moons; Jean Marie Stassen; Ingeborg Stalmans
The role of different VEGF isoforms in scar formation after glaucoma filtration surgery.

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All Publications

2012: Mieke Dewerchin; Peter Carmeliet
PlGF: a multitasking cytokine with disease-restricted activity.
Cold Spring Harbor perspectives in medicine 2012;2(8):.
2011: Goedele Wallays; Zsuzsanna Callaerts-Vegh; Peter Carmeliet; Désiré Collen; Rudi D'Hooge; Florea Lupu; Lieve Moons; Dieter Nuyens; Robert Silasi-Mansat; Joris Souffreau; An Van Nuffelen; Mieke Dewerchin
Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(12):2881-8.
2011: Tine Van Bergen; Sara Van de Veire; Evelien Vandewalle; Mieke Dewerchin; Lieve Moons; Jean Marie Stassen; Ingeborg Stalmans
The role of different VEGF isoforms in scar formation after glaucoma filtration surgery.
Experimental eye research 2011;93(5):689-99.
2011: Claire Meissirel; Yvette Michotte; Salvatore Oliviero; Wim Robberecht; Véronique Rogemond; Carmen Ruiz de Almodovar; Paul Salin; Dietmar Schmucker; Inmaculada Segura; Ilse Smolders; Nicole Thomasset; Ludo Van Den Bosch; Pieter Vanden Berghe; Stefan Vinckier; Denis Vivien; Thomas Voets; Alain Chédotal; Naura Chounlamountri; Cathy Coulon; Karel Dassonville; Maria De Mol; Pierre de Rossi; Bérangère Deléglise; Mieke Dewerchin; Jérôme Honnorat; Ellen Knevels; Ellen Loyens; Carine Ali; Kristof Anthonis; Peter Carmeliet
VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13782-7.
2011: Xabier L Aranguren; Manu Beerens; Peter Carmeliet; Mieke Dewerchin; Wouter Vandevelde; Aernout Luttun
Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis.
Biochemical and biophysical research communications 2011;410(1):121-6.
2011: Thomas Schmidt; Marc Tjwa; Peter Vandenberghe; Catherine M Verfaillie; Stefan Vinckier; Karolien Beel; Tim H Brümmendorf; Geert Carmeliet; Sandra Cauwenberghs; Richard E Clark; Jan Cools; Kim De Keersmaecker; Maria De Mol; Mieke Dewerchin; Sérgio Dias; Rita Fragoso; Peter Fraisl; Andreas Hochhaus; Tessa Holyoake; Bart Jonckx; Michael Karin; Behzad Kharabi Masouleh; Maria Kleppe; Sonja Loges; Christa Maes; Shahin Rafii; Thomas Schenk; Peter Carmeliet
Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia.
Cancer cell 2011;19(6):740-53.
2011: Shahid Soomro; Almut Brand; Peter Carmeliet; Canan Cetin; Edward M Conway; Mieke Dewerchin; Gert Fricker; Pavlo Holenya; Cindy Horwedel; Herwig Jansen; V Badireenath Konkimalla; Tobias Langenberg; Anne Mahringer; Thomas Efferth
Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties.
Journal of cellular and molecular medicine 2011;15(5):1122-35.
2011: Michella Ghassibe-Sabbagh; Laurence Desmyter; Tobias Langenberg; Filip Claes; Odile Boute; Bénédicte Bayet; Philippe Pellerin; Karlien Hermans; Liesbeth Backx; Maria Adela Mansilla; Sandra Imoehl; Stefanie Nowak; Kerstin U Ludwig; Carlotta Baluardo; Melissa Ferrian; Peter Anthony Mossey; Markus Noethen; Mieke Dewerchin; Geneviève François; Nicole Revencu; Romain Vanwijck; Jacqueline Hecht; Elisabeth Mangold; Jeffrey Murray; Michele Rubini; Joris R Vermeesch; Hélène A Poirel; Peter Carmeliet; Miikka Vikkula
FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish.
American journal of human genetics 2011;88(2):150-61.
2011: Charlotte Rolny; Massimiliano Mazzone; Sònia Tugues; Damya Laoui; Irja Johansson; Cathy Coulon; Mario Leonardo Squadrito; Inmaculada Segura; Xiujuan Li; Ellen Knevels; Sandra Costa; Stefan Vinckier; Tom Dresselaer; Peter Åkerud; Maria De Mol; Henriikka Salomäki; Mia Phillipson; Sabine Wyns; Erik Larsson; Ian Buysschaert; Johan Botling; Uwe Himmelreich; Jo A Van Ginderachter; Michele De Palma; Mieke Dewerchin; Lena Claesson-Welsh; Peter Carmeliet
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
Cancer cell 2011;19(1):31-44.
2010: Karlien Hermans; Dontcho Kerjaschki; Annelii Ny; Fabrizio Orsenigo; Bin Ren; Stefan Schulte-Merker; Michael Simons; Wouter Vandevelde; Wei Zheng; Kari Alitalo; Kristof Anthonis; Monica Autiero; Filip Claes; Frank De Smet; Elisabetta Dejana; Mieke Dewerchin; Ilse Geudens; Evisa Gjini; Peter Carmeliet
Role of synectin in lymphatic development in zebrafish and frogs.
Blood 2010;116(17):3356-66.
2010: An Vanden Bosch; Tim Raemaekers; Sarah Denayer; Sophie Torrekens; Nico Smets; Karen Moermans; Mieke Dewerchin; Peter Carmeliet; Geert Carmeliet
NuSAP is essential for chromatin-induced spindle formation during early embryogenesis.
Journal of cell science 2010;123(Pt 19):3244-55.
2010: Ilse Geudens; Robert Herpers; Karlien Hermans; Inmaculada Segura; Carmen Ruiz de Almodovar; Jeroen Bussmann; Frank De Smet; Wouter Vandevelde; Benjamin M Hogan; Arndt Siekmann; Filip Claes; John C Moore; Anna Silvia Pistocchi; Sonja Loges; Massimiliano Mazzone; Giovanni Mariggi; Françoise Bruyère; Franco Cotelli; Dontscho Kerjaschki; Agnes Noël; Jean-Michel Foidart; Holger Gerhardt; Annelii Ny; Tobias Langenberg; Nathan D Lawson; Henricus J Duckers; Stefan Schulte-Merker; Peter Carmeliet; Mieke Dewerchin
Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(9):1695-702.
2010: Pipsa Saharinen; Hanna Helotera; Juho J Miettinen; Camilla Norrmen; Gabriela D'Amico; Michael Jeltsch; Tobias Langenberg; Wouter Vandevelde; Annelii Ny; Mieke Dewerchin; Peter Carmeliet; Kari Alitalo
Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.
Genes & development 2010;24(9):875-80.
2010: Sonja Loges; Thomas Schmidt; Marc Tjwa; Katie van Geyte; Dirk Lievens; Esther Lutgens; Davy Vanhoutte; Delphine Borgel; Stephane Plaisance; Marc Hoylaerts; Aernout Luttun; Mieke Dewerchin; Bart Jonckx; Peter Carmeliet
Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.
Blood 2010;115(11):2264-73.
2010: Camilla Norrmén; Wouter Vandevelde; Annelii Ny; Pipsa Saharinen; Massimiliano Gentile; Guttorm Haraldsen; Pauli Puolakkainen; Eugene Lukanidin; Mieke Dewerchin; Kari Alitalo; Tatiana V Petrova
Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity.
Blood 2010;115(4):906-9.
2009: Marta Koch; Daniela Dettori; An Van Nuffelen; Joris Souffreau; Lucia Marconcini; Goedele Wallays; Lieve Moons; Françoise Bruyère; Salvatore Oliviero; Agnes Noel; Jean-Michel Foidart; Peter Carmeliet; Mieke Dewerchin
VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis.
The Journal of pathology 2009;219(3):356-64.
2009: Zhongqiu Li; Tine Van Bergen; Sara Van de Veire; Isabelle Van de Vel; Huberte Moreau; Mieke Dewerchin; Prabhat C Maudgal; Thierry Zeyen; Werner Spileers; Lieve Moons; Ingeborg Stalmans
Inhibition of vascular endothelial growth factor reduces scar formation after glaucoma filtration surgery.
Investigative ophthalmology & visual science 2009;50(11):5217-25.
2009: Marc Tjwa; Rute Moura; Lieve Moons; Stephane Plaisance; Maria De Mol; Sandra Jansen; Mieke Dewerchin; Catherine Verfaillie; Peter Carmeliet
Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation.
Journal of cellular and molecular medicine 2009;13(11-12):4587-95.
2009: Hussein M Atta; Ayman Al-Hendy; Mahmoud A El-Rehany; Mieke Dewerchin; Salama R Abdel Raheim; Hend Abdel Ghany; Rasha Fouad
Adenovirus-mediated overexpression of human tissue plasminogen activator prevents peritoneal adhesion formation/reformation in rats.
Surgery 2009;146(1):12-7.
2009: Marc Tjwa; Nicolai Sidenius; Rute Moura; Sandra Jansen; Koen Theunissen; Annapaola Andolfo; Maria De Mol; Mieke Dewerchin; Lieve Moons; Francesco Blasi; Catherine Verfaillie; Peter Carmeliet
Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.
The Journal of clinical investigation 2009;119(4):1008-18.
2009: Serena Zacchigna; Hideyasu Oh; Michaela Wilsch-Bräuninger; Ewa Missol-Kolka; József Jászai; Sandra Jansen; Naoyuki Tanimoto; Felix Tonagel; Mathias W Seeliger; Wieland B Huttner; Denis Corbeil; Mieke Dewerchin; Stefan Vinckier; Lieve Moons; Peter Carmeliet
Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(7):2297-308.
2009: H Roger Lijnen; Liesbeth Frederix; B Van Hoef; Mieke Dewerchin
Deficiency of vascular endothelial growth factor-D does not affect murine adipose tissue development.
Biochemical and biophysical research communications 2009;378(2):255-8.
2009: Pieter Vermeersch; Emmanuel Buys; Patrick Sips; Peter Pokreisz; Glenn Marsboom; Hilde Gillijns; Marijke Pellens; Mieke Dewerchin; Kenneth D Bloch; Peter Brouckaert; Stefan Janssens
Gender-specific modulation of the response to arterial injury by soluble guanylate cyclase α1.
The open cardiovascular medicine journal 2009;3():98-104.
2008: Tina Van Den Broeck; Frederik Stevenaert; Sylvie Taveirne; Veronique Debacker; Christel Vangestel; Bart Vandekerckhove; Tom Taghon; Patrick Matthys; Jean Plum; Werner Held; Mieke Dewerchin; Wayne M Yokoyama; Georges Leclercq
Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator.
Blood 2008;112(13):5046-51.
2008: Xuri Li; Marc Tjwa; Inge Van Hove; Berndt Enholm; Elke Neven; Karri Paavonen; Michael Jeltsch; Toni Diez Juan; Richard E Sievers; Emmanuel Chorianopoulos; Hiromichi Wada; Maarten Vanwildemeersch; Agnes Noel; Jean-Michel Foidart; Matthew L Springer; Georges von Degenfeld; Mieke Dewerchin; Helen M Blau; Kari Alitalo; Ulf Eriksson; Peter Carmeliet; Lieve Moons
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(9):1614-20.
2008: Annelii Ny; Marta Koch; Wouter Vandevelde; Martin Schneider; Christian Fischer; Antonio Diez-juan; Elke Neven; Ilse Geudens; Sunit Maity; Lieve Moons; Stephane Plaisance; Diether Lambrechts; Peter Carmeliet; Mieke Dewerchin
Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles.
Blood 2008;112(5):1740-9.
2008: Berta Vidal; Antonio L Serrano; Marc Tjwa; Mònica Suelves; Esther Ardite; Roberta De Mori; Bernat Baeza-Raja; María Martínez de Lagrán; Peggy Lafuste; Vanessa Ruiz-Bonilla; Mercè Jardí; Romain Gherardi; Christo Christov; Mara Dierssen; Peter Carmeliet; Jay L Degen; Mieke Dewerchin; Pura Muñoz-Cánoves
Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway.
Genes & development 2008;22(13):1747-52.
2008: Emmanuel Buys; Patrick Sips; Pieter Vermeersch; Michael Raher; Elke Rogge; Fumito Ichinose; Mieke Dewerchin; Kenneth D Bloch; Stefan Janssens; Peter Brouckaert
Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice.
Cardiovascular research 2008;79(1):179-86.
2008: Marc Tjwa; Lola Bellido-Martin; Yuan Lin; Esther Lutgens; Stephane Plaisance; Françoise Bono; Nathalie Delesque-Touchard; Caroline Hervé; Rute Moura; An D Billiau; Cristina Aparicio; Marcel Levi; Mat Daemen; Mieke Dewerchin; Florea Lupu; Jef Arnout; Jean-Marc Herbert; Mark Waer; Pablo García de Frutos; Björn Dahlbäck; Peter Carmeliet; Marc F Hoylaerts; Lieve Moons
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.
Blood 2008;111(8):4096-105.
2007: Christian Fischer; Bart Jonckx; Massimiliano Mazzone; Serena Zacchigna; Sonja Loges; Lucia Pattarini; Emmanuel Chorianopoulos; Laurens Liesenborghs; Marta Koch; Maria De Mol; Monica Autiero; Sabine Wyns; Stephane Plaisance; Lieve Moons; Nico van Rooijen; Mauro Giacca; Jean Marie Stassen; Mieke Dewerchin; Désiré Collen; Peter Carmeliet
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.
Cell 2007;131(3):463-75.
2007: Frederik Van Dyck; Caroline V Braem; Zhao Chen; Jeroen Declercq; Rob Deckers; Byeong-Moo Kim; Susumu Ito; Michele K Wu; David E Cohen; Mieke Dewerchin; Rita Derua; Etienne Waelkens; Laurence Fiette; Anton J M Roebroek; Frans Schuit; Wim J M Van De Ven; Ramesh A Shivdasani
Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.
Cell metabolism 2007;6(5):406-13.
2007: Pavel Uhrin; Christian Schöfer; Jan Zaujec; Lubos Ryban; Mario Hilpert; Klara Weipoltshammer; Ingrid Jerabek; Irene Pirtzkall; Margareta Furtmüller; Mieke Dewerchin; Bernd R Binder; Margarethe Geiger
Male fertility and protein C inhibitor/plasminogen activator inhibitor-3 (PCI): localization of PCI in mouse testis and failure of single plasminogen activator knockout to restore spermatogenesis in PCI-deficient mice.
Fertility and sterility 2007;88(4 Suppl):1049-57.
2007: Mònica Suelves; Berta Vidal; Antonio L Serrano; Marc Tjwa; Josep Roma; Roser López-Alemany; Aernout Luttun; María Martínez de Lagrán; Angels Díaz-Ramos; Maria Angels Díaz; Mercè Jardí; Manuel Roig; Mara Dierssen; Mieke Dewerchin; Peter Carmeliet; Pura Muñoz-Cánoves
uPA deficiency exacerbates muscular dystrophy in MDX mice.
The Journal of cell biology 2007;178(6):1039-51.
2007: Pieter Vermeersch; Emmanuel Buys; Peter Pokreisz; Glenn Marsboom; Fumito Ichinose; Patrick Sips; Marijke Pellens; Hilde Gillijns; Marc Swinnen; Amanda R Graveline; Désiré Collen; Mieke Dewerchin; Peter Brouckaert; Kenneth D Bloch; Stefan Janssens
Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia.
Circulation 2007;116(8):936-43.
2006: Marc Jacquemin; Catherine M Radcliffe; Renaud Lavend'homme; Mark R Wormald; Luc VanderElst; G Wallays; J Dewaele; Désiré Collen; Jos Vermylen; Raymond A Dwek; Jean-Marie Saint-Remy; Pauline M Rudd; Mieke Dewerchin
Variable region heavy chain glycosylation determines the anticoagulant activity of a factor VIII antibody.
Journal of thrombosis and haemostasis : JTH 2006;4(5):1047-55.
2005: Annelii Ny; Marta Koch; Martin Schneider; Elke Neven; Ricky T Tong; Sunit Maity; Christian Fischer; Stephane Plaisance; Diether Lambrechts; Christophe Héligon; Sven Terclavers; Malgorzata Ciesiolka; Roland Kälin; Wing Yan Man; Irena Senn; Sabine Wyns; Florea Lupu; André Brändli; Kris Vleminckx; Désiré Collen; Mieke Dewerchin; Edward M Conway; Lieve Moons; Rakesh K Jain; Peter Carmeliet
A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
Nature medicine 2005;11(9):998-1004.
2005: Ilka Ott; Cornelia Michaelis; Maren Schuermann; Birgit Steppich; Isabell Seitz; Mieke Dewerchin; Dietlind Zohlnhofer; Rainer Wessely; Martina Rudelius; Albert Schömig; Peter Carmeliet
Vascular remodeling in mice lacking the cytoplasmic domain of tissue factor.
Circulation research 2005;97(3):293-8.
2005: Till Acker; Antonio Diez-juan; Julian Aragones; Marc Tjwa; Koen Brusselmans; Lieve Moons; Dai Fukumura; Maria Paz Moreno-Murciano; Jean-Marc Herbert; Angelika Burger; Johanna Riedel; Gerd Elvert; Ingo Flamme; Patrick H Maxwell; Désiré Collen; Mieke Dewerchin; Rakesh K Jain; Karl H Plate; Peter Carmeliet
Genetic evidence for a tumor suppressor role of HIF-2alpha.
Cancer cell 2005;8(2):131-41.
2005: Els Melis; Lieve Moons; Jef Arnout; Marc F Hoylaerts; Désiré Collen; Peter Carmeliet; Mieke Dewerchin
Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain.
Biochemical and biophysical research communications 2005;333(2):488-95.
2005: Koen Brusselmans; Françoise Bono; Désiré Collen; Jean-Marc Herbert; Peter Carmeliet; Mieke Dewerchin
A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia.
The Journal of biological chemistry 2005;280(5):3493-9.
2005: Xuri Li; Marc Tjwa; Lieve Moons; Pierre Fons; Agnès Noel; Annelii Ny; Jian Min Zhou; Johan Lennartsson; Hong Li; Aernout Luttun; Annica Pontén; Laetitia Devy; Ann Bouché; Hideyasu Oh; Ann Manderveld; Silvia Blacher; David Communi; Pierre Savi; Françoise Bono; Mieke Dewerchin; Jean-Michel Foidart; Monica Autiero; Jean-Marc Herbert; Désiré Collen; Carl-Henrik Heldin; Ulf Eriksson; Peter Carmeliet
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.
The Journal of clinical investigation 2005;115(1):118-27.
2005: Erik Storkebaum; Diether Lambrechts; Mieke Dewerchin; Maria-Paz Moreno-Murciano; Saskia Appelmans; Hideyasu Oh; Philip Van Damme; Bart Rutten; Wing Yan Man; Maria De Mol; Sabine Wyns; David Manka; Kristel Vermeulen; Ludo Van Den Bosch; Nico Mertens; Christoph Schmitz; Wim Robberecht; Edward M Conway; Désiré Collen; Lieve Moons; Peter Carmeliet
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.
Nature neuroscience 2005;8(1):85-92.
2004: Karen Hensen; Caroline V Braem; Jeroen Declercq; Frederik Van Dyck; Mieke Dewerchin; Laurence Fiette; Carl Denef; Wim J M Van De Ven
Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility.
Development, growth & differentiation 2004;46(5):459-70.
2004: Aleyde van Eynde; Mieke Nuytten; Mieke Dewerchin; Luc Schoonjans; Stefaan Keppens; Monique Beullens; Lieve Moons; Peter Carmeliet; Willy Stalmans; Mathieu Bollen
The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation.
Molecular and cellular biology 2004;24(13):5863-74.
2004: Karel De Gendt; Johannes V Swinnen; Philippa Saunders; Luc Schoonjans; Mieke Dewerchin; Ann Devos; Karen Tan; Nina Atanassova; Frank Claessens; Charlotte Lécureuil; Walter Heyns; Peter Carmeliet; Florian Guillou; Richard M Sharpe; Guido Verhoeven
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1327-32.
2004: Mieke Dewerchin; L Van der Elst; I Singh; Sabrina Grailly; Jean-Marie Saint-Remy; Désiré Collen; Marc Jacquemin
Inhibition of factor VIII with a partially inhibitory human recombinant monoclonal antibody prevents thrombotic events in a transgenic model of type II HBS antithrombin deficiency in mice.
Journal of thrombosis and haemostasis : JTH 2004;2(1):77-84.
2003: Veerle Compernolle; Koen Brusselmans; Diego Franco; Antoon Moorman; Mieke Dewerchin; Désiré Collen; Peter Carmeliet
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha.
Cardiovascular research 2003;60(3):569-79.
2003: Mieke Dewerchin; Jean-Pascal Hérault; Goedele Wallays; Maurice Petitou; Paul Schaeffer; Laurence Millet; Jeffrey I Weitz; Lieve Moons; Désiré Collen; Peter Carmeliet; Jean-Marc Herbert
Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin.
Circulation research 2003;93(11):1120-6.
2003: Pedro Brites; Alison M Motley; Pierre Gressens; Petra A W Mooyer; Ingrid Ploegaert; Vincent Everts; Philippe Evrard; Peter Carmeliet; Mieke Dewerchin; Luc Schoonjans; Marinus Duran; Hans R Waterham; Ronald J A Wanders; Myriam Baes
Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata.
Human molecular genetics 2003;12(18):2255-67.
2003: Carlos Roger Molinas; Rudi Campo; Mieke Dewerchin; Ulf Eriksson; Peter Carmeliet; Philippe Robert Koninckx
Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice.
Fertility and sterility 2003;80 Suppl 2():803-11.
2003: Monica Autiero; Johannes Waltenberger; David Communi; Andrea Kranz; Lieve Moons; Diether Lambrechts; Jens Kroll; Stephane Plaisance; Maria De Mol; Françoise Bono; Stefanie Kliche; Guido Fellbrich; Kurt Ballmer-Hofer; Domenico Maglione; Ulrike Mayr-Beyrle; Mieke Dewerchin; Saskia Dombrowski; Danica Stanimirovic; Paul van Hummelen; Christoph Dehio; Daniel J Hicklin; Graziella Persico; Jean-Marc Herbert; David Communi; Masabumi Shibuya; Désiré Collen; Edward M Conway; Peter Carmeliet
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1.
Nature medicine 2003;9(7):936-43.
2002: Aernout Luttun; Marc Tjwa; Lieve Moons; Yan Wu; Anne Angelillo-Scherrer; Fang Liao; Janice A Nagy; Andrea Hooper; Josef Priller; Bert De Klerck; Veerle Compernolle; Evis Daci; Peter Bohlen; Mieke Dewerchin; Jean-Marc Herbert; Roy Fava; Patrick Matthys; Geert Carmeliet; Désiré Collen; Harold F Dvorak; Daniel J Hicklin; Peter Carmeliet
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.
Nature medicine 2002;8(8):831-40.
2002: Veerle Compernolle; Koen Brusselmans; Till Acker; Peter Hoet; Marc Tjwa; Heike Beck; Stephane Plaisance; Yuval Dor; Eli Keshet; Florea Lupu; Benoit Nemery; Mieke Dewerchin; Paul P Van Veldhoven; Karl H Plate; Lieve Moons; Désiré Collen; Peter Carmeliet
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice.
Nature medicine 2002;8(7):702-10.
2002: Myriam Baes; Mieke Dewerchin; Anneleen Janssen; Désiré Collen; Peter Carmeliet
Generation of Pex5-loxP mice allowing the conditional elimination of peroxisomes.
Genesis (New York, N.Y. : 2000) 2002;32(2):177-8.
2002: Ingeborg Stalmans; Yin-Shan Ng; Richard M Rohan; Marcus Fruttiger; Ann Bouché; Ali Yuce; Hajime Fujisawa; Bart Hermans; Moshe Shani; Sandra Jansen; Daniel J Hicklin; David J Anderson; Tom Gardiner; Hans-Peter Hammes; Lieve Moons; Mieke Dewerchin; Désiré Collen; Peter Carmeliet; Patricia A D'Amore
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms.
The Journal of clinical investigation 2002;109(3):327-36.
2001: Sophie van Cromphaut; Mieke Dewerchin; Joost G J Hoenderop; Ingrid Stockmans; Erik Van Herck; S Kato; René J M Bindels; Désiré Collen; Peter Carmeliet; Roger Bouillon; Geert Carmeliet
Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13324-9.
2001: Mark Ver Heyen; Stephane Heymans; Gudrun Antoons; T Reed; Muthu Periasamy; Bonaventure L Awede; Jean Lebacq; Peter Vangheluwe; Mieke Dewerchin; Désiré Collen; Karin R Sipido; Peter Carmeliet; Frank Wuytack
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
Circulation research 2001;89(9):838-46.
2001: Koen Brusselmans; Françoise Bono; P Maxwell; Yuval Dor; Mieke Dewerchin; Désiré Collen; Jean-Marc Herbert; Peter Carmeliet
Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia.
The Journal of biological chemistry 2001;276(42):39192-6.
2001: Dieter Nuyens; Milan Stengl; S Dugarmaa; Tom Rossenbacker; Veerle Compernolle; Yoram Rudy; Jos F M Smits; Willem Flameng; colleen clancy; Lieve Moons; Marc A Vos; Mieke Dewerchin; Klaus Benndorf; Désiré Collen; Edward Carmeliet; Peter Carmeliet
Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome.
Nature medicine 2001;7(9):1021-7.
2001: Els Melis; Lieve Moons; Maria De Mol; Jean-Marc Herbert; Nigel Mackman; Désiré Collen; Peter Carmeliet; Mieke Dewerchin
Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development.
Biochemical and biophysical research communications 2001;286(3):580-6.
2001: Mieke Dewerchin; Désiré Collen; H Roger Lijnen
Enhanced fibrinolytic potential in mice with combined homozygous deficiency of alpha2-antiplasmin and PAI-1.
Thrombosis and haemostasis 2001;86(2):640-6.
2001: Peter Carmeliet; Lieve Moons; Aernout Luttun; V Vincenti; Veerle Compernolle; Maria De Mol; Y Wu; Françoise Bono; Laetitia Devy; Heike Beck; Dimitri Scholz; Till Acker; T DiPalma; Mieke Dewerchin; Agnès Noel; Ingeborg Stalmans; A Barra; Silvia Blacher; Thierry VandenDriessche; A Ponten; Ulf Eriksson; Karl H Plate; Jean-Michel Foidart; Wolfgang Schaper; D S Charnock-Jones; Daniel J Hicklin; Jean-Marc Herbert; Désiré Collen; M Graziella Persico
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.
Nature medicine 2001;7(5):575-83.
2001: T Kawasaki; Mieke Dewerchin; H Roger Lijnen; Ingrid Vreys; Jos Vermylen; Marc F Hoylaerts
Mouse carotid artery ligation induces platelet-leukocyte-dependent luminal fibrin, required for neointima development.
Circulation research 2001;88(2):159-66.
2001: Anne Angelillo-Scherrer; P de Frutos; C Aparicio; Els Melis; Pierre Savi; Florea Lupu; Jef Arnout; Mieke Dewerchin; Marc F Hoylaerts; J Herbert; Désiré Collen; B Dahlbäck; Peter Carmeliet
Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.
Nature medicine 2001;7(2):215-21.
2000: Pavel Uhrin; Mieke Dewerchin; M Hilpert; Peter Chrenek; Christian Schöfer; Margareta Zechmeister-Machhart; Gerhard Krönke; Anja Vales; P Carmeliet; Bernd R Binder; Margarethe Geiger
Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility.
The Journal of clinical investigation 2000;106(12):1531-9.
2000: Aernout Luttun; Mieke Dewerchin; D Collen; P Carmeliet
The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke: insights from genetic studies.
Current atherosclerosis reports 2000;2(5):407-16.
2000: T Kawasaki; Mieke Dewerchin; H Roger Lijnen; Jos Vermylen; Marc F Hoylaerts
Vascular release of plasminogen activator inhibitor-1 impairs fibrinolysis during acute arterial thrombosis in mice.
Blood 2000;96(1):153-60.
2000: H Roger Lijnen; Berthe Van Hoef; Mieke Dewerchin; Désiré Collen
Alpha(2)-antiplasmin gene deficiency in mice does not affect neointima formation after vascular injury.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(6):1488-92.
2000: Mieke Dewerchin; Z Liang; Lieve Moons; Peter Carmeliet; Francis J Castellino; Désiré Collen; Elliot D Rosen
Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice.
Thrombosis and haemostasis 2000;83(2):185-90.
1999: Peter Carmeliet; Maria Grazia Lampugnani; Lieve Moons; Ferruccio Breviario; Veerle Compernolle; Françoise Bono; Giovanna Balconi; Raffaella Spagnuolo; B Oosthuyse; Mieke Dewerchin; Adriana Zanetti; A Angellilo; Virginie Mattot; Dieter Nuyens; Esther Lutgens; Frédéric Clotman; M C de Ruiter; A Gittenberger-de Groot; R Poelmann; Florea Lupu; Jean-Marc Herbert; Désiré Collen; Elisabetta Dejana
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.
Cell 1999;98(2):147-57.
1999: Peter Carmeliet; Yin-Shan Ng; Dieter Nuyens; Gregor Theilmeier; Koen Brusselmans; I Cornelissen; E Ehler; V V Kakkar; Ingeborg Stalmans; Virginie Mattot; J C Perriard; Mieke Dewerchin; Willem Flameng; Andras Nagy; Florea Lupu; Lieve Moons; Désiré Collen; Patricia A D'Amore; David T Shima
Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.
Nature medicine 1999;5(5):495-502.
1999: H Roger Lijnen; K Okada; Osamu Matsuo; Désiré Collen; Mieke Dewerchin
Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding.
Blood 1999;93(7):2274-81.
1998: Peter Carmeliet; Yuval Dor; Jean-Marc Herbert; D Fukumura; Koen Brusselmans; Mieke Dewerchin; Michal Neeman; Françoise Bono; Rinat Abramovitch; P Maxwell; C J Koch; P Ratcliffe; Lieve Moons; R K Jain; Désiré Collen; E Keshert; E Keshet
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
Nature 1998;394(6692):485-90.
1998: Peter Carmeliet; Lieve Moons; Mieke Dewerchin; S Rosenberg; Jean-Marc Herbert; Florea Lupu; Désiré Collen
Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice.
The Journal of cell biology 1998;140(1):233-45.
1997: K Okada; H Roger Lijnen; Mieke Dewerchin; A Belayew; Osamu Matsuo; Désiré Collen; R Bernaerts
Characterization and targeting of the murine alpha2-antiplasmin gene.
Thrombosis and haemostasis 1997;78(3):1104-10.
1997: Peter Carmeliet; Lieve Moons; Mieke Dewerchin; Nigel Mackman; T Luther; Georg Breier; V Ploplis; M Müller; Andras Nagy; E Plow; Robert D Gerard; T Edgington; Werner Risau; Désiré Collen
Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system.
Annals of the New York Academy of Sciences 1997;811():191-206.
1996: Mieke Dewerchin; A V Nuffelen; G Wallays; A Bouché; Lieve Moons; Peter Carmeliet; R C Mulligan; Désiré Collen
Generation and characterization of urokinase receptor-deficient mice.
The Journal of clinical investigation 1996;97(3):870-8.
1993: Paul Holvoet; Mieke Dewerchin; Jean Marie Stassen; H Roger Lijnen; T Tollenaere; P J Gaffney; Désiré Collen
Thrombolytic profiles of clot-targeted plasminogen activators. Parameters determining potency and initial and maximal rates.
Circulation 1993;87(3):1007-16.
1992: Mieke Dewerchin; Anne-Mieke Vandamme; Paul Holvoet; F De Cock; Griet Lemmens; H Roger Lijnen; Jean Marie Stassen; Désiré Collen
Thrombolytic and pharmacokinetic properties of a recombinant chimeric plasminogen activator consisting of a fibrin fragment D-dimer specific humanized monoclonal antibody and a truncated single-chain urokinase.
Thrombosis and haemostasis 1992;68(2):170-9.
1992: Anne-Mieke Vandamme; Mieke Dewerchin; H Roger Lijnen; H Bernar; F Bulens; Luc Nelles; Désiré Collen
Characterization of a recombinant chimeric plasminogen activator composed of a fibrin fragment-D-dimer-specific humanized monoclonal antibody and a truncated single-chain urokinase.
European journal of biochemistry / FEBS 1992;205(1):139-46.
1991: Mieke Dewerchin; Désiré Collen
Enhancement of the thrombolytic potency of plasminogen activators by conjugation with clot-specific monoclonal antibodies.
Bioconjugate chemistry 1991;2(5):293-300.
1991: Mieke Dewerchin; H Roger Lijnen; Jean Marie Stassen; F De Cock; T Quertermous; M H Ginsberg; Edward F Plow; Désiré Collen
Effect of chemical conjugation of recombinant single-chain urokinase-type plasminogen activator with monoclonal antiplatelet antibodies on platelet aggregation and on plasma clot lysis in vitro and in vivo.
Blood 1991;78(4):1005-18.
1990: Désiré Collen; Mieke Dewerchin; H J Rapold; H Roger Lijnen; Jean Marie Stassen
Thrombolytic and pharmacokinetic properties of a conjugate of recombinant single-chain urokinase-type plasminogen activator with a monoclonal antibody specific for cross-linked fibrin in a baboon venous thrombosis model.
Circulation 1990;82(5):1744-53.
1990: H Roger Lijnen; Mieke Dewerchin; F De Cock; Désiré Collen
Effect of fibrin-targeting on clot lysis with urokinase-type plasminogen activator.
Thrombosis research 1990;57(3):333-42.
1989: Mieke Dewerchin; H Roger Lijnen; Berthe Van Hoef; F De Cock; Désiré Collen
Biochemical properties of conjugates of urokinase-type plasminogen activator with a monoclonal antibody specific for cross-linked fibrin.
European journal of biochemistry / FEBS 1989;185(1):141-9.