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David DeWitt
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Chemicals & Drugs
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Physiology
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Network (preview)
27
Smith, William
17
Nair, Muraleedharan
5
Garavito, Michael
4
Ramsewak, Russel
4
Strasburg, Gale
3
Zhang, Yanjun
3
Mulabagal, Vanisree
2
Murugesan, Sorimuthu
2
Leipprandt, Jeffrey
2
Booren, AM
2
Wang, H
2
Thuresson, Elizabeth
2
Song, Inseok
2
Spencer, AG
2
Smith, T
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Geonetwork of David DeWitt (preview)
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All Publications
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2009: Mulabagal Vanisree; Subbaraju Gottumukkala V; Rao Chirravuri V; Sivaramakrishna Chillara; Dewitt David L; Holmes Daniel; Sung Bokyung; Aggarwal Bharat B; Tsay Hsin-Sheng; Nair Muraleedharan G
Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation.
Phytotherapy research : PTR 2009;23(7):987-92.
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2009: Mulabagal Vanisree; Lang Gregory A; DeWitt David L; Dalavoy Sanjeev S; Nair Muraleedharan G
Anthocyanin content, lipid peroxidation and cyclooxygenase enzyme inhibitory activities of sweet and sour cherries.
Journal of agricultural and food chemistry 2009;57(4):1239-46.
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2008: Raman Priyadarshini; Dewitt David L; Nair Muraleedharan G
Lipid peroxidation and cyclooxygenase enzyme inhibitory activities of acidic aqueous extracts of some dietary supplements.
Phytotherapy research : PTR 2008;22(2):204-12.
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2007: Mulabagal Vanisree; Van Nocker Steven; Dewitt David L; Nair Muraleedharan G
Cultivars of apple fruits that are not marketed with potential for anthocyanin production.
Journal of agricultural and food chemistry 2007;55(20):8165-9.
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2006: Mbonye Uri R; Wada Masayuki; Rieke Caroline J; Tang Hui-Yuan; Dewitt David L; Smith William L
The 19-amino acid cassette of cyclooxygenase-2 mediates entry of the protein into the endoplasmic reticulum-associated degradation system.
The Journal of biological chemistry 2006;281(47):35770-8.
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2006: MirAfzali Zahra; Leipprandt Jeffrey R; McCracken John L; DeWitt David L
Topography of the prostaglandin endoperoxide H2 synthase-2 in membranes.
The Journal of biological chemistry 2006;281(38):28354-64.
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2006: Jayaprakasam Bolleddula; Vanisree Mulabagal; Zhang Yanjun; Dewitt David L; Nair Muraleedharan G
Impact of alkyl esters of caffeic and ferulic acids on tumor cell proliferation, cyclooxygenase enzyme, and lipid peroxidation.
Journal of agricultural and food chemistry 2006;54(15):5375-81.
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2005: MirAfzali Zahra; Leipprandt Jeffrey R; McCracken John L; DeWitt David L
Fast, efficient reconstitution of the cyclooxygenases into proteoliposomes.
Archives of biochemistry and biophysics 2005;443(1-2):60-5.
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2005: Zhang Yanjun; Dewitt David L; Murugesan Sorimuthu; Nair Muraleedharan G
Cyclooxygenase-2 enzyme inhibitory triterpenoids from Picrorhiza kurroa seeds.
Life sciences 2005;77(25):3222-30.
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2004: Zhang Yanjun; DeWitt David L; Murugesan Sorimuthu; Nair Muraleedharan G
Novel lipid-peroxidation- and cyclooxygenase-inhibitory tannins from Picrorhiza kurroa seeds.
Chemistry & biodiversity 2004;1(3):426-41.
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2002: Garavito R Michael; Malkowski Michael G; DeWitt David L
The structures of prostaglandin endoperoxide H synthases-1 and -2.
Prostaglandins & other lipid mediators 2002;68-69():129-52.
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2002: Clifford L J; Nair M G; Rana J; Dewitt D L
Bioactivity of alkamides isolated from Echinacea purpurea (L.) Moench.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2002;9(3):249-53.
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2002: Henry Geneive E; Momin Rafikali A; Nair Muraleedharan G; Dewitt David L
Antioxidant and cyclooxygenase activities of fatty acids found in food.
Journal of agricultural and food chemistry 2002;50(8):2231-4.
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2002: Wu Di; Nair Muraleedharan G; DeWitt David L
Novel compounds from Piper methysticum Forst (Kava Kava) roots and their effect on cyclooxygenase enzyme.
Journal of agricultural and food chemistry 2002;50(4):701-5.
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2002: Wu D; Yu L; Nair M G; DeWitt D L; Ramsewak R S
Cyclooxygenase enzyme inhibitory compounds with antioxidant activities from Piper methysticum (kava kava) roots.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2002;9(1):41-7.
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2000: Proshlyakov D A; Pressler M A; DeMaso C; Leykam J F; DeWitt D L; Babcock G T
Oxygen activation and reduction in respiration: involvement of redox-active tyrosine 244.
Science (New York, N.Y.) 2000;290(5496):1588-91.
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2000: Ramsewak R S; DeWitt D L; Nair M G
Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2000;7(4):303-8.
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2000: Wang H; Nair M G; Strasburg G M; Booren A M; Gray I; Dewitt D L
Cyclooxygenase active bioflavonoids from Balaton tart cherry and their structure activity relationships.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2000;7(1):15-9.
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2000: Kelm M A; Nair M G; Strasburg G M; DeWitt D L
Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2000;7(1):7-13.
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2000: Smith W L; DeWitt D L; Garavito R M
Cyclooxygenases: structural, cellular, and molecular biology.
Annual review of biochemistry 2000;69():145-82.
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1999: Ramsewak R S; Nair M G; DeWitt D L; Mattson W G; Zasada J
Phenolic glycosides from Dirca palustris.
Journal of natural products 1999;62(11):1558-61.
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1999: Garavito R M; DeWitt D L
The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins.
Biochimica et biophysica acta 1999;1441(2-3):278-87.
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1999: Spencer A G; Thuresson E; Otto J C; Song I; Smith T; DeWitt D L; Garavito R M; Smith W L
The membrane binding domains of prostaglandin endoperoxide H synthases 1 and 2. Peptide mapping and mutational analysis.
The Journal of biological chemistry 1999;274(46):32936-42.
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1999: DeWitt D L
Cox-2-selective inhibitors: the new super aspirins.
Molecular pharmacology 1999;55(4):625-31.
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1999: Ramsewak R S; Nair M G; Strasburg G M; DeWitt D L; Nitiss J L
Biologically active carbazole alkaloids from Murraya koenigii.
Journal of agricultural and food chemistry 1999;47(2):444-7.
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1999: Wang H; Nair M G; Strasburg G M; Chang Y C; Booren A M; Gray J I; DeWitt D L
Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries.
Journal of natural products 1999;62(2):294-6.
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1998: Li Y; Smith T; Grabski S; DeWitt D L
The membrane association sequences of the prostaglandin endoperoxide synthases-1 and -2 isozymes.
The Journal of biological chemistry 1998;273(45):29830-7.
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1997: Smith W L; DeWitt D L; Arakawa T; Spencer A G; Thuresson E D; Song I
Independent prostanoid biosynthetic systems associated with prostaglandin endoperoxide synthases-1 and -2.
Thrombosis and haemostasis 1997;78(1):627-30.
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1997: Smith W L; Meade E A; Dewitt D L
Interaction of PGH synthase isozymes-1 and -2 with nonsteroidal anti-inflammatory drugs.
Advances in experimental medicine and biology 1997;400A():189-96.
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1996: Smith W L; Garavito R M; DeWitt D L
Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2.
The Journal of biological chemistry 1996;271(52):33157-60.
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1996: Arakawa T; Laneuville O; Miller C A; Lakkides K M; Wingerd B A; DeWitt D L; Smith W L
Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells. Structure and expression of the murine prostaglandin EP4 receptor gene.
The Journal of biological chemistry 1996;271(47):29569-75.
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1996: Kraemer S A; Arthur K A; Denison M S; Smith W L; DeWitt D L
Regulation of prostaglandin endoperoxide H synthase-2 expression by 2,3,7,8,-tetrachlorodibenzo-p-dioxin.
Archives of biochemistry and biophysics 1996;330(2):319-28.
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1996: Smith W L; Dewitt D L
Prostaglandin endoperoxide H synthases-1 and -2.
Advances in immunology 1996;62():167-215.
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1995: Laneuville O; Breuer D K; Xu N; Huang Z H; Gage D A; Watson J T; Lagarde M; DeWitt D L; Smith W L
Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid.
The Journal of biological chemistry 1995;270(33):19330-6.
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1995: Morita I; Schindler M; Regier M K; Otto J C; Hori T; DeWitt D L; Smith W L
Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2.
The Journal of biological chemistry 1995;270(18):10902-8.
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1995: Regier M K; Otto J C; DeWitt D L; Smith W L
Localization of prostaglandin endoperoxide synthase-1 to the endoplasmic reticulum and nuclear envelope is independent of its C-terminal tetrapeptide-PTEL.
Archives of biochemistry and biophysics 1995;317(2):457-63.
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1994: Laneuville O; Breuer D K; Dewitt D L; Hla T; Funk C D; Smith W L
Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.
The Journal of pharmacology and experimental therapeutics 1994;271(2):927-34.
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1994: Smith W L; Meade E A; DeWitt D L
Interactions of PGH synthase isozymes-1 and -2 with NSAIDs.
Annals of the New York Academy of Sciences 1994;744():50-7.
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1994: Lecomte M; Laneuville O; Ji C; DeWitt D L; Smith W L
Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.
The Journal of biological chemistry 1994;269(18):13207-15.
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1994: Smith W L; Meade E A; DeWitt D L
Pharmacology of prostaglandin endoperoxide synthase isozymes-1 and -2.
Annals of the New York Academy of Sciences 1994;714():136-42.
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1993: DeWitt D L; Meade E A
Serum and glucocorticoid regulation of gene transcription and expression of the prostaglandin H synthase-1 and prostaglandin H synthase-2 isozymes.
Archives of biochemistry and biophysics 1993;306(1):94-102.
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1993: DeWitt D L; Meade E A; Smith W L
PGH synthase isoenzyme selectivity: the potential for safer nonsteroidal antiinflammatory drugs.
The American journal of medicine 1993;95(2A):40S-44S.
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1993: Otto J C; DeWitt D L; Smith W L
N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.
The Journal of biological chemistry 1993;268(24):18234-42.
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1993: Reiger M K; DeWitt D L; Schindler M S; Smith W L
Subcellular localization of prostaglandin endoperoxide synthase-2 in murine 3T3 cells.
Archives of biochemistry and biophysics 1993;301(2):439-44.
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1993: Meade E A; Smith W L; DeWitt D L
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
The Journal of biological chemistry 1993;268(9):6610-4.
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1993: Meade E A; Smith W L; DeWitt D L
Expression of the murine prostaglandin (PGH) synthase-1 and PGH synthase-2 isozymes in cos-1 cells.
Journal of lipid mediators 1993;6(1-3):119-29.
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1992: Kraemer S A; Meade E A; DeWitt D L
Prostaglandin endoperoxide synthase gene structure: identification of the transcriptional start site and 5'-flanking regulatory sequences.
Archives of biochemistry and biophysics 1992;293(2):391-400.
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1991: DeWitt D L
Prostaglandin endoperoxide synthase: regulation of enzyme expression.
Biochimica et biophysica acta 1991;1083(2):121-34.
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1991: Smith W L; DeWitt D L; Shimokawa T
The aspirin and heme binding sites of PGG/H synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():77-80.
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1991: DeWitt D L; Kraemer S A; Meade E A
Serum induction and superinduction of PGG/H synthase mRNA levels in 3T3 fibroblasts.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():65-8.
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1990: Smith W L; DeWitt D L; Shimokawa T; Kraemer S A; Meade E A
Molecular basis for the inhibition of prostanoid biosynthesis by nonsteroidal anti-inflammatory agents.
Stroke; a journal of cerebral circulation 1990;21(12 Suppl):IV24-8.
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1990: Shimokawa T; Kulmacz R J; DeWitt D L; Smith W L
Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis.
The Journal of biological chemistry 1990;265(33):20073-6.
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1990: DeWitt D L; el-Harith E A; Kraemer S A; Andrews M J; Yao E F; Armstrong R L; Smith W L
The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.
The Journal of biological chemistry 1990;265(9):5192-8.
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1990: Smith W L; DeWitt D L; Kraemer S A; Andrews M J; Hla T; Maciag T; Shimokawa T
Structure-function relationships in sheep, mouse, and human prostaglandin endoperoxide G/H synthases.
Advances in prostaglandin, thromboxane, and leukotriene research 1990;20():14-21.
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1989: DeWitt D L; el-Harith E A; Smith W L
Molecular cloning of prostaglandin G/H synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():454-7.
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1987: Inoue M; Smith W L; DeWitt D L
Molecular characterization of the prostacyclin synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():29-33.
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