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Grant Dewson

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Peter Czabotar; Grant Dewson; W Douglas Fairlie; Colin Hockings; David C S Huang; Ruth M Kluck; Erinna Lee; Stephen Ma; Adeline Y Robin; Brian J Smith; Dana Westphal; Shenggen Yao; Jerry M Adams; Peter M Colman
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
V H Tran; D Westphal; A Alsop; R Bartolo; Grant Dewson; Ruth M Kluck
Bak apoptotic function is not directly regulated by phosphorylation.
Grant Dewson; P Frederick; C Hockings; Tobias Kratina; S Ma; I Tan; Ruth M Kluck
Bax dimerizes via a symmetric BH3:groove interface during apoptosis.

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All Publications

2013: Peter Czabotar; Grant Dewson; W Douglas Fairlie; Colin Hockings; David C S Huang; Ruth M Kluck; Erinna Lee; Stephen Ma; Adeline Y Robin; Brian J Smith; Dana Westphal; Shenggen Yao; Jerry M Adams; Peter M Colman
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
Cell 2013;152(3):519-31.
2013: V H Tran; D Westphal; A Alsop; R Bartolo; Grant Dewson; Ruth M Kluck
Bak apoptotic function is not directly regulated by phosphorylation.
Cell death & disease 2013;4():e452.
2012: Grant Dewson; P Frederick; C Hockings; Tobias Kratina; S Ma; I Tan; Ruth M Kluck
Bax dimerizes via a symmetric BH3:groove interface during apoptosis.
Cell death and differentiation 2012;19(4):661-70.
2012: V R Sutton; J A Trapani; P I Bird; M E Christensen; Grant Dewson; R W Johnstone; Ruth M Kluck; Karin A Sedelies; N J Waterhouse
Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737.
Cell death & disease 2012;3():e344.
2012: Pedro Eitz Ferrer; Paul Frederick; Jacqueline M Gulbis; Grant Dewson; Ruth M Kluck
Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function.
PloS one 2012;7(3):e31510.
2011: Erinna Lee; Matthew A Perugini; Anne Pettikiriarachchi; Brian J Smith; Peter M Colman; Grant Dewson; C Dogovski; Marco Evangelista; W Douglas Fairlie
Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins.
Structure (London, England : 1993) 2011;19(10):1467-76.
2011: Ben A Croker; Grant Dewson; Yifang Hu; Kurt Lackovic; Donald Metcalf; Cameron Nowell; Joanne A O'Donnell; Lorraine A O'Reilly; Philippe Bouillet; Kirsteen J Campbell; Louise H Cengia; Suzanne Cory; Kelly L Rogers; Gordon K Smyth; Andreas Strasser; Michael White; Jian-Guo Zhang; Andrew W Roberts
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(32):13135-40.
2011: Dana Westphal; Grant Dewson; Peter E Czabotar; Ruth M Kluck
Molecular biology of Bax and Bak activation and action.
Biochimica et biophysica acta 2011;1813(4):521-31.
2010: Lina Happo; Mark Cragg; Belinda Phipson; Jon M Haga; Elisa S Jansen; Marco J Herold; Grant Dewson; Ewa M Michalak; Cassandra J Vandenberg; Gordon K Smyth; Andreas Strasser; Suzanne Cory; Clare L Scott
Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim.
Blood 2010;116(24):5256-67.
2010: Michael Lazarou; Diana Stojanovski; Ann E Frazier; Aneta Kotevski; Grant Dewson; William J Craigen; Ruth M Kluck; David L Vaux; Michael T Ryan
Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor.
The Journal of biological chemistry 2010;285(47):36876-83.
2009: Grant Dewson; Tobias Kratina; Peter Czabotar; Catherine L Day; Jerry M Adams; Ruth M Kluck
Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.
Molecular cell 2009;36(4):696-703.
2009: Grant Dewson; Ruth M Kluck
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis.
Journal of cell science 2009;122(Pt 16):2801-8.
2008: Grant Dewson; Tobias Kratina; Huiyan W Sim; Hamsa Puthalakath; Jerry M Adams; Peter M Colman; Ruth M Kluck
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.
Molecular cell 2008;30(3):369-80.
2007: Nicholas D Huntington; Hamsa Puthalakath; Priscilla Gunn; Edwina Naik; Ewa M Michalak; Mark J Smyth; Hyacinth Tabarias; Mariapia A Degli-Esposti; Grant Dewson; Simon N Willis; Noboru Motoyama; David C S Huang; Stephen L Nutt; David M Tarlinton; Andreas Strasser
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.
Nature immunology 2007;8(8):856-63.
2007: Rachel Uren; Grant Dewson; Lin Chen; Stephanie C Coyne; David C S Huang; Jerry M Adams; Ruth M Kluck
Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.
The Journal of cell biology 2007;177(2):277-87.
2005: Simon N Willis; Lin Chen; Grant Dewson; Andrew Wei; Edwina Naik; Jamie I Fletcher; Jerry M Adams; David C S Huang
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.
Genes & development 2005;19(11):1294-305.
2005: Rachel Uren; Grant Dewson; Christine Bonzon; Trevor Lithgow; Donald D Newmeyer; Ruth M Kluck
Mitochondrial release of pro-apoptotic proteins: electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes.
The Journal of biological chemistry 2005;280(3):2266-74.
2004: David Dinsdale; Justine C Lee; Grant Dewson; Gerald M Cohen; Marcus E Peter
Intermediate filaments control the intracellular distribution of caspases during apoptosis.
The American journal of pathology 2004;164(2):395-407.
2003: Grant Dewson; Roger T Snowden; Jason B Almond; Martin J S Dyer; Gerald M Cohen
Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.
Oncogene 2003;22(17):2643-54.
2002: Grant Dewson; Edward C Conley; Peter Bradding
Multigene family isoform profiling from blood cell lineages.
BMC genomics 2002;3(1):22.
2001: Grant Dewson; Gerald M Cohen; Andrew J Wardlaw
Interleukin-5 inhibits translocation of Bax to the mitochondria, cytochrome c release, and activation of caspases in human eosinophils.
Blood 2001;98(7):2239-47.
2000: Gerrit Woltmann; CA McNulty; Grant Dewson; Fiona A Symon; Andrew J Wardlaw
Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow.
Blood 2000;95(10):3146-52.
1999: Grant Dewson; Garry Walsh; Andrew J Wardlaw
Expression of Bcl-2 and its homologues in human eosinophils. Modulation by interleukin-5.
American journal of respiratory cell and molecular biology 1999;20(4):720-8.
1998: Garry Walsh; Grant Dewson; Andrew J Wardlaw; F Levi-Schaffer; R Moqbel
A comparative study of different methods for the assessment of apoptosis and necrosis in human eosinophils.
Journal of immunological methods 1998;217(1-2):153-63.