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TM Dexter

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Lynne Hampson; Ian N Hampson; CK Babichuk; L Cotter; R Chris Bleackley; TM Dexter; Michael Cross
A minimal serpin promoter with high activity in haematopoietic progenitors and activated T cells.
JM Francis; Clare Heyworth; Elaine Spooncer; Andrew Pierce; TM Dexter; Anthony D Whetton
Transforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells.
Andrew Pierce; Elaine Spooncer; S Wooley; Caroline Dive; JM Francis; Jaleel A Miyan; P Jane Owen-Lynch; TM Dexter; Anthony D Whetton
Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation.

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All Publications

2001: Lynne Hampson; Ian N Hampson; CK Babichuk; L Cotter; R Chris Bleackley; TM Dexter; Michael Cross
A minimal serpin promoter with high activity in haematopoietic progenitors and activated T cells.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(3):150-60.
2000: JM Francis; Clare Heyworth; Elaine Spooncer; Andrew Pierce; TM Dexter; Anthony D Whetton
Transforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells.
The Journal of biological chemistry 2000;275(50):39137-45.
2000: Andrew Pierce; Elaine Spooncer; S Wooley; Caroline Dive; JM Francis; Jaleel A Miyan; P Jane Owen-Lynch; TM Dexter; Anthony D Whetton
Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation.
Oncogene 2000;19(48):5487-97.
2000: Zoe McIvor; Clare Heyworth; B A Johnson; S Pearson; Heike Fiegler; Lynne Hampson; TM Dexter; Michael Cross
A transient assay for regulatory gene function in haemopoietic progenitor cells.
British journal of haematology 2000;110(3):674-81.
2000: M Clemons; A Watson; A Howell; James Chang; Clare Heyworth; BI Lord; Nydia G Testa; TM Dexter; Geoffrey P Margison
Macrophage inflammatory protein 1alpha attenuates the toxic effects of temozolomide in human bone marrow granulocyte-macrophage colony-forming cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):966-70.
2000: U Just; D Boettiger; O Kan; TM Dexter; Elaine Spooncer
Insertional mutagenesis as a route to identifying genes involved in self renewal of haemopoietic stem cells.
Current topics in microbiology and immunology 2000;251():27-34.
1999: Jan Dürig; Nydia G Testa; BI Lord; Christoph Kasper; James Chang; N Telford; TM Dexter; Clare Heyworth
Characterisation of the differential response of normal and CML haemopoietic progenitor cells to macrophage inflammatory protein-1alpha.
Leukemia 1999;13(12):2012-22.
1999: Marina Scheller; John Foerster; Clare Heyworth; JF Waring; Jürgen Löhler; GL Gilmore; Richard K Shadduck; TM Dexter; Ivan Horak
Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein.
Blood 1999;94(11):3764-71.
1999: Nachimuthu Chinnasamy; Joseph Rafferty; Linda S Lashford; Dhanalakshmi Chinnasamy; Geoffrey P Margison; N Thatcher; TM Dexter; Leslie J Fairbairn
Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy.
Leukemia 1999;13(11):1776-83.
1999: Jaroslav Jelinek; Joseph Rafferty; Radek Cmejla; M Hildinger; Dhanalakshmi Chinnasamy; Linda S Lashford; Wolfram Ostertag; Geoffrey P Margison; TM Dexter; Leslie J Fairbairn; Christopher Baum
A novel dual function retrovirus expressing multidrug resistance 1 and O6-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents.
Gene therapy 1999;6(8):1489-93.
1999: B A Johnson; V A John; Reinhard Henschler; Ian N Hampson; Clare Heyworth; CK Babichuk; R Chris Bleackley; TM Dexter; Michael Cross
Upstream elements bestow T-cell and haemopoietic progenitor-specific activity on the granzyme B promoter.
Gene 1999;234(1):101-7.
1998: M J Clemons; E Marshall; Jan Dürig; K Watanabe; A Howell; D Miles; Helena Earl; J Kiernan; A Griffiths; K Towlson; P DeTakats; Nydia G Testa; M Dougal; MG Hunter; L M Wood; Lloyd Czaplewski; A Millar; TM Dexter; BI Lord
A randomized phase-II study of BB-10010 (macrophage inflammatory protein- 1alpha) in patients with advanced breast cancer receiving 5-fluorouracil, adriamycin, and cyclophosphamide chemotherapy.
Blood 1998;92(5):1532-40.
1998: Andrew Pierce; P Jane Owen-Lynch; Elaine Spooncer; TM Dexter; Anthony D Whetton
p210 Bcr-Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia.
Oncogene 1998;17(5):667-72.
1998: A Weaver; James Chang; E Wrigley; Erika A de Wynter; Penella J Woll; M Lind; B Jenkins; C Gill; Peter M Wilkinson; R Pettengell; John A Radford; Conor D Collins; TM Dexter; Nydia G Testa; Derek Crowther
Randomized comparison of progenitor-cell mobilization using chemotherapy, stem-cell factor, and filgrastim or chemotherapy plus filgrastim alone in patients with ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(8):2601-12.
1998: Tariq Enver; Clare Heyworth; TM Dexter
Do stem cells play dice?
Blood 1998;92(2):348-51; discussion 352.
1998: E Marshall; A H Howell; R Powles; MG Hunter; M Edwards; L M Wood; Lloyd Czaplewski; R Puttick; Steve Warrington; M Boyce; Nydia G Testa; TM Dexter; BI Lord; A Millar
Clinical effects of human macrophage inflammatory protein-1 alpha MIP-1 alpha (LD78) administration to humans: a phase I study in cancer patients and normal healthy volunteers with the genetically engineered variant, BB-10010.
European journal of cancer (Oxford, England : 1990) 1998;34(7):1023-9.
1998: Nachimuthu Chinnasamy; Joseph Rafferty; Ian Hickson; Linda S Lashford; S J Longhurst; N Thatcher; Geoffrey P Margison; TM Dexter; Leslie J Fairbairn
Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.
Gene therapy 1998;5(6):842-7.
1998: Ian Hickson; Leslie J Fairbairn; Nachimuthu Chinnasamy; Linda S Lashford; N Thatcher; Geoffrey P Margison; TM Dexter; Joseph Rafferty
Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro.
Gene therapy 1998;5(6):835-41.
1998: Christoph Kasper; A Schwarzer; Erika A de Wynter; James Chang; TM Dexter; D Ryder; Nydia G Testa
Recombinant human megakaryocyte growth and development factor (MGDF) increases the numbers of megakaryocyte progenitor cells to normal values in long-term bone marrow cultures of patients with AML in first remission.
Leukemia 1998;12(6):907-11.
1998: Andrew Pierce; Clare Heyworth; SE Nicholls; Elaine Spooncer; TM Dexter; J M Lord; P Jane Owen-Lynch; G Wark; Anthony D Whetton
An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events.
The Journal of cell biology 1998;140(6):1511-8.
1998: G Wark; Clare Heyworth; Elaine Spooncer; Lloyd Czaplewski; JM Francis; TM Dexter; Anthony D Whetton
Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha.
Oncogene 1998;16(10):1319-24.
1998: Andrew Pierce; Anthony D Whetton; P Jane Owen-Lynch; J Tavernier; Elaine Spooncer; TM Dexter; Clare Heyworth
Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line.
Journal of cell science 1998;111 ( Pt 6)():815-23.
1998: Robert F Wynn; Michael Cross; C Hatton; Andrew M Will; Linda S Lashford; TM Dexter; Nydia G Testa
Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants.
Lancet 1998;351(9097):178-81.
1998: M A Pearson; A M O'Farrell; TM Dexter; Anthony D Whetton; P Jane Owen-Lynch; Clare Heyworth
Investigation of the molecular mechanisms underlying growth factor synergy: the role of ERK 2 activation in synergy.
Growth factors (Chur, Switzerland) 1998;15(4):293-306.
1997: L H Coutinho; James Chang; ML Brereton; Godfrey R Morgenstern; John Howard Scarffe; C J Harrison; John A Liu Yin; P J Darbyshire; S Burdach; TM Dexter; Nydia G Testa
Autografting in Philadelphia (Ph)+ chronic myeloid leukaemia using cultured marrow: an update of a pilot study.
Bone marrow transplantation 1997;19(10):969-76.
1997: A Weaver; Penella J Woll; M Lind; B Jenkins; C Gill; TM Dexter; Nydia G Testa; D Crother
The mobilisation of peripheral blood progenitor cells using chemotherapy, stem cell factor and filgrastim or chemotherapy plus filgrastim alone: a randomised study.
Sangre 1997;42 Suppl 1():34.
1997: Nachimuthu Chinnasamy; Joseph Rafferty; Ian Hickson; J Ashby; H Tinwell; Geoffrey P Margison; TM Dexter; Leslie J Fairbairn
O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow.
Blood 1997;89(5):1566-73.
1997: J Jelínek; Leslie J Fairbairn; TM Dexter; Joseph Rafferty; C Stocking; C Baum; Wolfram Ostertag; G P Margison
[Will transfer of cytostatic drug resistance genes increase hematopoiesis resistance in the treatment of malignant tumors?].
Casopís lékar̆ů c̆eských 1997;136(1):22-6.
1997: Leslie J Fairbairn; Linda S Lashford; Elaine Spooncer; R H McDermott; G Lebens; J E Arrand; John R Arrand; Ilaria Bellantuono; R Holt; C E Hatton; Alan Cooper; G T N Besley; James Wraith; D S Anson; J J Hopwood; TM Dexter
Towards gene therapy of Hurler syndrome.
Casopís lékar̆ů c̆eských 1997;136(1):27-31.
1997: Elaine Spooncer; TM Dexter
Culturing primitive hemopoietic cells. Long-term mouse marrow cultures and the establishment of factor-dependent (FDCP-Mix) hemopoietic cell lines.
Methods in molecular biology (Clifton, N.J.) 1997;75():209-19.
1997: Michael Cross; Clare Heyworth; TM Dexter
How do stem cells decide what to do?
Ciba Foundation symposium 1997;204():3-14; discussion 14-8.
1997: K Stewart; OA Brown; Adrian E Morelli; Leslie J Fairbairn; Linda S Lashford; A Cooper; C E Hatton; TM Dexter; Maria G Castro; Pedro R Lowenstein
Uptake of alpha-(L)-iduronidase produced by retrovirally transduced fibroblasts into neuronal and glial cells in vitro.
Gene therapy 1997;4(1):63-75.
1997: Ian N Hampson; Lynne Hampson; Michael J Pinkoski; Michael Cross; Clare Heyworth; R Chris Bleackley; E Atkinson; TM Dexter
Identification of a serpin specifically expressed in multipotent and bipotent hematopoietic progenitor cells and in activated T cells.
Blood 1997;89(1):108-18.
1996: I Baumann; R Swindell; M E Van Hoeff; TM Dexter; Erika A de Wynter; C Lange; T Luft; Anthony Howell; Nydia G Testa
Mobilisation kinetics of primitive haemopoietic cells following G-CSF with or without chemotherapy for advanced breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1996;7(10):1051-7.
1996: Ian N Hampson; Lynne Hampson; TM Dexter
Directional random oligonucleotide primed (DROP) global amplification of cDNA: its application to subtractive cDNA cloning.
Nucleic acids research 1996;24(23):4832-5.
1996: A Weaver; E Wrigley; A Watson; J Chang; Conor D Collins; B Jenkins; C Gill; R Pettengell; TM Dexter; Nydia G Testa; Derek Crowther
A study of ovarian cancer patients treated with dose-intensive chemotherapy supported with peripheral blood progenitor cells mobilised by filgrastim and cyclophosphamide.
British journal of cancer 1996;74(11):1821-7.
1996: A Weaver; D Ryder; D Crowther; TM Dexter; Nydia G Testa
Increased numbers of long-term culture-initiating cells in the apheresis product of patients randomized to receive increasing doses of stem cell factor administered in combination with chemotherapy and a standard dose of granulocyte colony-stimulating factor.
Blood 1996;88(9):3323-8.
1996: Ian Hickson; Leslie J Fairbairn; Nachimuthu Chinnasamy; TM Dexter; Geoffrey P Margison; Joseph Rafferty
Protection of mammalian cells against chloroethylating agent toxicity by an O6-benzylguanine-resistant mutant of human O6-alkylguanine-DNA alkyltransferase.
Gene therapy 1996;3(10):868-77.
1996: Joseph Rafferty; Ian Hickson; Nachimuthu Chinnasamy; Linda S Lashford; Geoffrey P Margison; TM Dexter; Leslie J Fairbairn
Chemoprotection of normal tissues by transfer of drug resistance genes.
Cancer metastasis reviews 1996;15(3):365-83.
1996: S Bretti; M H Gilleece; A Kamthan; L Fitzsimmons; F Hicks; M Rowlands; P Bishop; A M Picardo; TM Dexter; John Howard Scarffe
An open phase I study to assess the biological effects of a continuous intravenous infusion of Interleukin-3 followed by Granulocyte Macrophage-Colony Stimulating Factor.
European journal of cancer (Oxford, England : 1990) 1996;32A(7):1171-8.
1996: L H Coutinho; ML Brereton; A M Santos; W D Ryder; James Chang; C J Harrison; John A Liu Yin; TM Dexter; Nydia G Testa
Evaluation of cytogenetic conversion to Ph- haemopoiesis in long-term bone marrow culture for patients with chronic myeloid leukaemia on conventional hydroxyurea therapy, on pulse high-dose hydroxyurea and on interferon-alpha.
British journal of haematology 1996;93(4):869-77.
1996: M H Gilleece; C M Heyworth; N G Testa; TM Dexter
Effects of interleukins on the proliferation and survival of chronic lymphocytic leukaemia cells.
Journal of clinical pathology 1996;49(5):437-8.
1996: Leslie J Fairbairn; Linda S Lashford; E Spooncer; R H McDermott; G Lebens; J E Arrand; J R Arrand; Ilaria Bellantuono; R Holt; C E Hatton; A Cooper; G T Besley; James Wraith; D S Anson; J J Hopwood; TM Dexter
Long-term in vitro correction of alpha-L-iduronidase deficiency (Hurler syndrome) in human bone marrow.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):2025-30.
1996: J Jelínek; Leslie J Fairbairn; TM Dexter; Joseph Rafferty; C Stocking; W Ostertag; Geoffrey P Margison
Long-term protection of hematopoiesis against the cytotoxic effects of multiple doses of nitrosourea by retrovirus-mediated expression of human O6-alkylguanine-DNA-alkyltransferase.
Blood 1996;87(5):1957-61.
1996: B M Reipert; D Allan; TM Dexter
Exposure to extremely low frequency magnetic fields has no effect on growth rate or clonogenic potential of multipotential haemopoietic progenitor cells.
Growth factors (Chur, Switzerland) 1996;13(3-4):205-17.
1995: MG Hunter; L Bawden; D Brotherton; S Craig; S Cribbes; Lloyd Czaplewski; TM Dexter; A H Drummond; A H Gearing; C M Heyworth; BI Lord; M McCourt; Paul Varley; L M Wood; R M Edwards; P J Lewis
BB-10010: an active variant of human macrophage inflammatory protein-1 alpha with improved pharmaceutical properties.
Blood 1995;86(12):4400-8.
1995: BI Lord; TM Dexter
Which are the hematopoietic stem cells? [or: don't debunk the history!].
Experimental hematology 1995;23(12):1237-41.
1995: G Laskay; T Várhelyi; R E Dale; TM Dexter
Role of interleukin-3 in the regulation of intracellular K+ homeostasis in cultured murine haemopoietic cells.
Biochemical and biophysical research communications 1995;214(2):348-53.
1995: Clare Heyworth; M Alauldin; Michael Cross; Leslie J Fairbairn; TM Dexter; Anthony D Whetton
Erythroid development of the FDCP-Mix A4 multipotent cell line is governed by the relative concentrations of erythropoietin and interleukin 3.
British journal of haematology 1995;91(1):15-22.
1995: U Just; O Kan; J Fennelly; TM Dexter; Elaine Spooncer
The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines.
Growth factors (Chur, Switzerland) 1995;12(3):173-7.
1995: Clare Heyworth; M A Pearson; TM Dexter; G Wark; P Jane Owen-Lynch; Anthony D Whetton
Macrophage inflammatory protein-1 alpha mediated growth inhibition in a haemopoietic stem cell line is associated with inositol 1,4,5 triphosphate generation.
Growth factors (Chur, Switzerland) 1995;12(3):165-72.
1995: R Pettengell; Penella J Woll; Nick Thatcher; TM Dexter; Nydia G Testa
Multicyclic, dose-intensive chemotherapy supported by sequential reinfusion of hematopoietic progenitors in whole blood.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(1):148-56.
1994: R Pettengell; T Luft; Reinhard Henschler; J M Hows; TM Dexter; D Ryder; Nydia G Testa
Direct comparison by limiting dilution analysis of long-term culture-initiating cells in human bone marrow, umbilical cord blood, and blood stem cells.
Blood 1994;84(11):3653-9.
1994: R Pettengell; Penella J Woll; D A O'Connor; TM Dexter; Nydia G Testa
Viability of haemopoietic progenitors from whole blood, bone marrow and leukapheresis product: effects of storage media, temperature and time.
Bone marrow transplantation 1994;14(5):703-9.
1994: Michael Cross; Clare Heyworth; A M Murrell; EO Bockamp; TM Dexter; Anthony R Green
Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line.
Oncogene 1994;9(10):3013-6.
1994: Clare Heyworth; TM Dexter; S E Nicholls; Anthony D Whetton
Combinations of colony-stimulating factors promote enhanced proliferative potential in enriched granulocyte-macrophage colony-forming cells.
Experimental hematology 1994;22(11):1089-94.
1994: Leslie J Fairbairn; G J Cowling; TM Dexter; Joseph Rafferty; Geoffrey P Margison; B Reipert
bcl-2 delay of alkylating agent-induced apoptotic death in a murine hemopoietic stem cell line.
Molecular carcinogenesis 1994;11(1):49-55.
1994: G J Cowling; TM Dexter
Apoptosis in the haemopoietic system.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;345(1313):257-63.
1994: U Just; Elaine Spooncer; J Löhler; Carol Stocking; Wolfram Ostertag; TM Dexter
Mutants of a multipotent hematopoietic cell line blocked in GM-CSF-induced differentiation are leukemogenic in vivo.
Experimental hematology 1994;22(9):933-40.
1994: G Molineux; A Migdalska; J Haley; Gareth Simon Evans; TM Dexter
Total marrow failure induced by pegylated stem-cell factor administered before 5-fluorouracil.
Blood 1994;83(12):3491-9.
1994: Anthony D Whetton; Clare Heyworth; SE Nicholls; C A Evans; J M Lord; TM Dexter; P Jane Owen-Lynch
Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells.
The Journal of cell biology 1994;125(3):651-9.
1994: Elaine Spooncer; Leslie J Fairbairn; G J Cowling; TM Dexter; Anthony D Whetton; P Jane Owen-Lynch
Biological consequences of p160v-abl protein tyrosine kinase activity in a primitive, multipotent haemopoietic cell line.
Leukemia 1994;8(4):620-30.
1994: M E Van Hoef; I Baumann; C Lange; T Luft; Erika A de Wynter; Malcolm Ranson; Godfrey R Morgenstern; A Yvers; TM Dexter; Nydia G Testa
Dose-escalating induction chemotherapy supported by lenograstim preceding high-dose consolidation chemotherapy for advanced breast cancer. Selection of the most acceptable regimen to induce maximal tumor response and investigation of the optimal time to collect peripheral blood progenitor cells for haematological rescue after high-dose consolidation chemotherapy.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5(3):217-24.
1994: TM Dexter; Clare Heyworth
Growth factors and the molecular control of haematopoiesis.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1994;13 Suppl 2():S3-8.
1994: TM Dexter
Granulocyte colony stimulating factor: from laboratory bench to clinical use.
European journal of cancer (Oxford, England : 1990) 1994;30A Suppl 3():S15-9.
1993: A D Whetton; TM Dexter
Influence of growth factors and substrates on differentiation of haemopoietic stem cells.
Current opinion in cell biology 1993;5(6):1044-9.
1993: Erika A de Wynter; T Allen; L Coutinho; David Flavell; S U Flavell; TM Dexter
Localisation of granulocyte macrophage colony-stimulating factor in human long-term bone marrow cultures. Biological and immunocytochemical characterisation.
Journal of cell science 1993;106 ( Pt 3)():761-9.
1993: R Pettengell; Nydia G Testa; R Swindell; D Crowther; TM Dexter
Transplantation potential of hematopoietic cells released into the circulation during routine chemotherapy for non-Hodgkin's lymphoma.
Blood 1993;82(7):2239-48.
1993: Leslie J Fairbairn; G J Cowling; B M Reipert; TM Dexter
Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors.
Cell 1993;74(5):823-32.
1993: Clare Heyworth; TM Dexter; S E Nicholls; Anthony D Whetton
Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells.
Blood 1993;81(4):894-900.
1993: I Baumann; Nydia G Testa; C Lange; Erika A de Wynter; T Luft; TM Dexter; M E van Hoef; Anthony Howell
Haemopoietic cells mobilised into the circulation by lenograstim as alternative to bone marrow for allogeneic transplants.
Lancet 1993;341(8841):369.
1993: Leslie J Fairbairn; James P Stewart; Ian N Hampson; John R Arrand; TM Dexter
Expression of Epstein-Barr virus latent membrane protein influences self-renewal and differentiation in a multipotential murine haemopoietic 'stem cell' line.
The Journal of general virology 1993;74 ( Pt 2)():247-54.
1992: Ian N Hampson; Michael Cross; Clare Heyworth; Leslie J Fairbairn; Elaine Spooncer; G J Cowling; TM Dexter
Expression and downregulation of cytotoxic cell protease 1 or Granzyme 'B' transcripts during myeloid differentiation of interleukin-3-dependent murine stem cell lines.
Blood 1992;80(12):3097-105.
1992: Nydia G Testa; TM Dexter
Colony-stimulating factors in the clinic.
Current opinion in biotechnology 1992;3(6):687-92.
1992: Clare Heyworth; Anthony D Whetton; S Nicholls; Krisztina Maria Zsebo; TM Dexter
Stem cell factor directly stimulates the development of enriched granulocyte-macrophage colony-forming cells and promotes the effects of other colony-stimulating factors.
Blood 1992;80(9):2230-6.
1992: G J Cowling; TM Dexter
Erythropoietin and myeloid colony stimulating factors.
Trends in biotechnology 1992;10(10):349-57.
1992: J M Hows; B A Bradley; J C Marsh; T Luft; L Coutinho; Nydia G Testa; TM Dexter
Growth of human umbilical-cord blood in longterm haemopoietic cultures.
Lancet 1992;340(8811):73-6.
1992: M H Gilleece; John Howard Scarffe; A Ghosh; C M Heyworth; E Bonnem; N Testa; Peter L Stern; TM Dexter
Recombinant human interleukin 4 (IL-4) given as daily subcutaneous injections--a phase I dose toxicity trial.
British journal of cancer 1992;66(1):204-10.
1992: Ian N Hampson; L Pope; G J Cowling; TM Dexter
Chemical cross linking subtraction (CCLS): a new method for the generation of subtractive hybridisation probes.
Nucleic acids research 1992;20(11):2899.
1992: BI Lord; TM Dexter; John M Clements; M A Hunter; A J Gearing
Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo.
Blood 1992;79(10):2605-9.
1992: H Demuynck; R Pettengell; E de Campos; TM Dexter; Nydia G Testa
The capacity of peripheral blood stem cells mobilised with chemotherapy plus G-CSF to repopulate irradiated marrow stroma in vitro is similar to that of bone marrow.
European journal of cancer (Oxford, England : 1990) 1992;28(2-3):381-6.
1992: J M Hows; J C Marsh; B A Bradley; T Luft; L Coutinho; Nydia G Testa; TM Dexter
Human cord blood: a source of transplantable stem cells?
Bone marrow transplantation 1992;9 Suppl 1():105-8.
1991: O Kan; Clare Heyworth; TM Dexter; P J Maudsley; N Cook; S J Vallance; Anthony D Whetton
Interferon-gamma stimulates the survival and influences the development of bipotential granulocyte-macrophage colony-forming cells.
Blood 1991;78(10):2588-94.
1991: G Molineux; A Migdalska; M Szmitkowski; K Zsebo; TM Dexter
The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor.
Blood 1991;78(4):961-6.
1991: J C Marsh; J Chang; Nydia G Testa; J M Hows; TM Dexter
In vitro assessment of marrow 'stem cell' and stromal cell function in aplastic anaemia.
British journal of haematology 1991;78(2):258-67.
1991: BI Lord; G Molineux; Z Pojda; L M Souza; J J Mermod; TM Dexter
Myeloid cell kinetics in mice treated with recombinant interleukin-3, granulocyte colony-stimulating factor (CSF), or granulocyte-macrophage CSF in vivo.
Blood 1991;77(10):2154-9.
1991: J Hampson; S Redmond; BI Lord; P Slocombe; A M O'Farrell; Clare Heyworth; TM Dexter
Selective inhibition of primitive hemopoietic colony-forming cells by an extract from normal marrow: comparison with transforming growth factor-beta.
Experimental hematology 1991;19(4):245-9.
1991: TM Dexter
Growth and differentiation in the haemopoietic system.
Biochemical Society transactions 1991;19(2):303-6.
1991: U Just; Carol Stocking; Elaine Spooncer; TM Dexter; Wolfram Ostertag
Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation.
Cell 1991;64(6):1163-73.
1991: Michael Cross; TM Dexter
Growth factors in development, transformation, and tumorigenesis.
Cell 1991;64(2):271-80.
1991: Clare Heyworth; J Hampson; TM Dexter; F Walker; A W Burgess; O Kan; N Cook; S J Vallance; Anthony D Whetton
Development of multipotential haemopoietic stem cells to neutrophils is associated with increased expression of receptors for granulocyte macrophage colony-stimulating factor: altered biological responses to GM-CSF during development.
Growth factors (Chur, Switzerland) 1991;5(2):87-98.
1991: A Migdalska; G Molineux; H Demuynck; Gareth Simon Evans; F Ruscetti; TM Dexter
Growth inhibitory effects of transforming growth factor-beta 1 in vivo.
Growth factors (Chur, Switzerland) 1991;4(3):239-45.
1991: I L Ponting; Clare Heyworth; F Cormier; TM Dexter
Serum-free culture of enriched murine haemopoietic stem cells. II: Effects of growth factors and haemin on development.
Growth factors (Chur, Switzerland) 1991;4(3):165-73.
1991: F Cormier; I L Ponting; Clare Heyworth; TM Dexter
Serum-free culture of enriched murine haemopoietic stem cells. I: Effect of haemopoietic growth factors on proliferation.
Growth factors (Chur, Switzerland) 1991;4(3):157-64.
1991: J C Marsh; J Chang; Nydia G Testa; J M Hows; TM Dexter
Purification of aplastic anaemia (AA) marrow haemopoietic progenitors combined with long-term marrow cultures (LTMC) to assess haemopoiesis in AA.
Bone marrow transplantation 1991;7 Suppl 2():98.
1990: G Molineux; Z Pojda; Ian N Hampson; BI Lord; TM Dexter
Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor.
Blood 1990;76(10):2153-8.
1990: R Schiró; L H Coutinho; A Will; J Chang; Nydia G Testa; TM Dexter
Growth of normal versus leukemic bone marrow cells in long term culture from acute lymphoblastic and myeloblastic leukemias.
Blut 1990;61(5):267-70.
1990: J C Marsh; James Chang; Nydia G Testa; J M Hows; TM Dexter
The hematopoietic defect in aplastic anemia assessed by long-term marrow culture.
Blood 1990;76(9):1748-57.
1990: L H Coutinho; A Will; J Radford; R Schiró; Nydia G Testa; TM Dexter
Effects of recombinant human granulocyte colony-stimulating factor (CSF), human granulocyte macrophage-CSF, and gibbon interleukin-3 on hematopoiesis in human long-term bone marrow culture.
Blood 1990;75(11):2118-29.
1990: Nydia G Testa; TM Dexter
Cell lineages in haemopoiesis: comments on their regulation.
Seminars in immunology 1990;2(3):167-72.
1990: TM Dexter; Clare Heyworth; Elaine Spooncer; I L Ponting
The role of growth factors in self-renewal and differentiation of haemopoietic stem cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1990;327(1239):85-98.
1990: G Molineux; Z Pojda; TM Dexter
A comparison of hematopoiesis in normal and splenectomized mice treated with granulocyte colony-stimulating factor.
Blood 1990;75(3):563-9.
1990: Elaine Spooncer; TM Dexter
Culturing Primitive Hemopoietic Cells : Long-Term Mouse Marrow Cultures and the Establishment of Factor-Dependent (FDCP-Mix) Hemopoietic Cell Lines.
Methods in molecular biology (Clifton, N.J.) 1990;5():277-88.
1990: L H Coutinho; Nydia G Testa; J Chang; Godfrey R Morgenstern; C Harrison; TM Dexter
The use of cultured bone marrow cells in autologous transplantation.
Progress in clinical and biological research 1990;333():415-32; discussion 433.
1990: TM Dexter
Introduction to the haemopoietic system.
Cancer surveys 1990;9(1):1-5.
1990: TM Dexter; L H Coutinho; E Spooncer; Clare Heyworth; C P Daniel; R Schiro; J Chang; Terence Allen
Stromal cells in haemopoiesis.
Ciba Foundation symposium 1990;148():76-86; discussion 86-95.
1990: J M Garland; TM Dexter; N G Testa
Colony-stimulating factors: future prospects.
Immunology series 1990;49():465-7.
1990: W P Steward; John Howard Scarffe; TM Dexter; Nydia G Testa
Clinical application of hematopoietic growth factors.
Immunology series 1990;49():359-78.
1990: Terence Allen; TM Dexter; P J Simmons
Marrow biology and stem cells.
Immunology series 1990;49():1-38.
1990: Clare Heyworth; S J Vallance; Anthony D Whetton; TM Dexter
The biochemistry and biology of the myeloid haemopoietic cell growth factors.
Journal of cell science. Supplement 1990;13():57-74.
1990: Clare Heyworth; TM Dexter; O Kan; Anthony D Whetton
The role of hemopoietic growth factors in self-renewal and differentiation of IL-3-dependent multipotential stem cells.
Growth factors (Chur, Switzerland) 1990;2(2-3):197-211.
1990: Z Pojda; G Molineux; TM Dexter
Hemopoietic effects of short-term in vivo treatment of mice with various doses of rhG-CSF.
Experimental hematology 1990;18(1):27-31.
1989: Anthony D Whetton; TM Dexter
Myeloid haemopoietic growth factors.
Biochimica et biophysica acta 1989;989(2):111-32.
1989: C P Daniel; TM Dexter
The role of growth factors in haemopoietic development: clinical and biological implications.
Cancer metastasis reviews 1989;8(3):253-62.
1989: Z Pojda; G Molineux; TM Dexter
Effects of long-term in vivo treatment of mice with purified murine recombinant GM-CSF.
Experimental hematology 1989;17(11):1100-4.
1989: BI Lord; M H Bronchud; S Owens; J Chang; Anthony Howell; L Souza; TM Dexter
The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9499-503.
1989: N Cook; TM Dexter; B I Lord; E J Cragoe; Anthony D Whetton
Identification of a common signal associated with cellular proliferation stimulated by four haemopoietic growth factors in a highly enriched population of granulocyte/macrophage colony-forming cells.
The EMBO journal 1989;8(10):2967-74.
1989: Nydia G Testa; TM Dexter
Long-term hematopoietic damage: concepts, approaches, and results relevant to the study of environmental toxins.
Environmental health perspectives 1989;82():51-6.
1989: TM Dexter
Regulation of hemopoietic cell growth and development: experimental and clinical studies.
Leukemia 1989;3(7):469-74.
1989: M H Bronchud; Anthony Howell; Derek Crowther; P Hopwood; L Souza; TM Dexter
The use of granulocyte colony-stimulating factor to increase the intensity of treatment with doxorubicin in patients with advanced breast and ovarian cancer.
British journal of cancer 1989;60(1):121-5.
1989: A J Morris; TM Dexter; John T Gallagher
Metabolic properties of a homogeneous proteoglycan of a haemopoietic stem cell line, FDCP-mix.
The Biochemical journal 1989;260(2):479-86.
1989: Ian N Hampson; Elaine Spooncer; TM Dexter
Evaluation of a mouse Y chromosome probe for assessing marrow transplantation.
Experimental hematology 1989;17(3):313-5.
1989: Elaine Spooncer; M Katsuno; Ian N Hampson; TM Dexter; U Just; Carol Stocking; N Kluge; Wolfram Ostertag
Biological effects of retroviral transfection of the murine interleukin-3 gene into FDCP-Mix cells.
Current topics in microbiology and immunology 1989;149():109-16.
1989: C P Daniel; I L Ponting; TM Dexter
Growth and development of haemopoietic cells: a deterministic process?
Haematology and blood transfusion 1989;32():172-7.
1989: J Chang; Godfrey R Morgenstern; L H Coutinho; John Howard Scarffe; T Carr; David P Deakin; Nydia G Testa; TM Dexter
The use of bone marrow cells grown in long-term culture for autologous bone marrow transplantation in acute myeloid leukaemia: an update.
Bone marrow transplantation 1989;4(1):5-9.
1989: J Hampson; I L Ponting; N Cook; L Vodinelich; S Redmond; A B Roberts; TM Dexter
The effects of TGF beta on haemopoietic cells.
Growth factors (Chur, Switzerland) 1989;1(2):193-202.
1988: Anthony D Whetton; S J Vallance; Peter N Monk; E J Cragoe; TM Dexter; Clare Heyworth
Interleukin-3-stimulated haemopoietic stem cell proliferation. Evidence for activation of protein kinase C and Na+/H+ exchange without inositol lipid hydrolysis.
The Biochemical journal 1988;256(2):585-92.
1988: Clare Heyworth; I L Ponting; TM Dexter
The response of haemopoietic cells to growth factors: developmental implications of synergistic interactions.
Journal of cell science 1988;91 ( Pt 2)():239-47.
1988: I L Ponting; TM Dexter
The role of colony stimulating factors, interleukin 1 and stromal extracellular matrix in the regulation of stem cell development.
Behring Institute Mitteilungen 1988;(83):48-55.
1988: M Bronchud; John Howard Scarffe; Nick Thatcher; Derek Crowther; L M Souza; N K Alton; Nydia G Testa; TM Dexter
Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer.
Behring Institute Mitteilungen 1988;(83):327-9.
1988: Anthony D Whetton; Peter N Monk; S D Consalvey; S J Huang; TM Dexter; C P Downes
Interleukin 3 stimulates proliferation via protein kinase C activation without increasing inositol lipid turnover.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3284-8.
1988: Z Pojda; TM Dexter; BI Lord
Production of a multipotential cell (CFU-S) proliferation inhibitor by various populations of mouse and human macrophages.
British journal of haematology 1988;68(2):153-7.
1988: Clare Heyworth; TM Dexter
The development of hemopoietic cells in response to stromal cells or growth factors is modified by agents that influence ADP-ribosylation.
Leukemia 1988;2(1):6-11.
1988: TM Dexter; I L Ponting; R A Roberts; Elaine Spooncer; Clare Heyworth; J T Gallagher
Growth and differentiation of hematopoietic stem cells.
Society of General Physiologists series 1988;43():25-38.
1988: Jaroslav Jelinek; K Kleibl; TM Dexter; G P Margison
Transfection of murine multi-potent haemopoietic stem cells with an E. coli DNA alkyltransferase gene confers resistance to the toxic effects of alkylating agents.
Carcinogenesis 1988;9(1):81-7.
1987: M H Bronchud; John Howard Scarffe; Nick Thatcher; Derek Crowther; L M Souza; N K Alton; Nydia G Testa; TM Dexter
Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer.
British journal of cancer 1987;56(6):809-13.
1987: Nydia G Testa; L Coutinho; J Chang; G Morgenstern; John Howard Scarffe; TM Dexter
The use of cultured bone marrow cells for autologous transplantation in patients with acute myeloblastic leukemia.
Haematology and blood transfusion 1987;31():75-8.
1986: J Chang; L Coutinho; G Morgenstern; John Howard Scarffe; D Deakin; C Harrison; Nydia G Testa; TM Dexter
Reconstitution of haemopoietic system with autologous marrow taken during relapse of acute myeloblastic leukaemia and grown in long-term culture.
Lancet 1986;1(8476):294-5.
1986: A J Morris; J T Gallagher; TM Dexter
Combined use of lectin affinity chromatography and endo-beta-galactosidase to study polylactosamine sequences isolated from haemopoietic cell surfaces.
Biomedical chromatography : BMC 1986;1(1):41-7.
1986: BI Lord; G Molineux; Nydia G Testa; Michael Kelly; E Spooncer; TM Dexter
The kinetic response of haemopoietic precursor cells, in vivo, to highly purified, recombinant interleukin-3.
Lymphokine research 1986;5(2):97-104.