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Zandrea Ambrose

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Valerie F Boltz; Zandrea Ambrose; Mary F Kearney; Vineet N KewalRamani; Frank Maldarelli; John W Mellors; Wei Shao; John M Coffin
Ultrasensitive allele-specific PCR reveals rare preexisting drug-resistant variants and a large replicating virus population in macaques infected with a simian immunodeficiency virus containing human immunodeficiency virus reverse transcriptase.
Zandrea Ambrose; Alan Engelman; Stephen H Hughes; KyeongEun Lee; James Matous; Jean Ndjomou; Ilker Oztop; Taichiro Takemura; Derya Unutmaz; Hongzhan Xu; Vineet N KewalRamani
Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection.
Orlando Acevedo; Zandrea Ambrose; Patrick T Flaherty; Prashi Jain; Hadega Aamer; Somisetti V Sambasivarao
Identification of HIV inhibitors guided by free energy perturbation calculations.

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2012: Valerie F Boltz; Zandrea Ambrose; Mary F Kearney; Vineet N KewalRamani; Frank Maldarelli; John W Mellors; Wei Shao; John M Coffin
Ultrasensitive allele-specific PCR reveals rare preexisting drug-resistant variants and a large replicating virus population in macaques infected with a simian immunodeficiency virus containing human immunodeficiency virus reverse transcriptase.
Journal of virology 2012;86(23):12525-30.
2012: Zandrea Ambrose; Alan Engelman; Stephen H Hughes; KyeongEun Lee; James Matous; Jean Ndjomou; Ilker Oztop; Taichiro Takemura; Derya Unutmaz; Hongzhan Xu; Vineet N KewalRamani
Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection.
Journal of virology 2012;86(8):4708-14.
2012: Orlando Acevedo; Zandrea Ambrose; Patrick T Flaherty; Prashi Jain; Hadega Aamer; Somisetti V Sambasivarao
Identification of HIV inhibitors guided by free energy perturbation calculations.
Current pharmaceutical design 2012;18(9):1199-216.
2011: Sangmi Jun; Danxia Ke; Xin Meng; Simon C Watkins; Zandrea Ambrose; Karl Debiec; Gregory A Gibson; Gongpu Zhao; Peijun Zhang
Direct visualization of HIV-1 with correlative live-cell microscopy and cryo-electron tomography.
Structure (London, England : 1993) 2011;19(11):1573-81.
2010: KyeongEun Lee; Zandrea Ambrose; Thomas D Martin; Ilker Oztop; Alok Mulky; John G Julias; Nick Vandegraaff; Joerg G Baumann; Rui Wang; Wendy Yuen; Taichiro Takemura; Kenneth Shelton; Ichiro Taniuchi; Yuan Li; Joseph Sodroski; Dan R Littman; John M Coffin; Stephen H Hughes; Derya Unutmaz; Alan Engelman; Vineet N KewalRamani
Flexible use of nuclear import pathways by HIV-1.
Cell host & microbe 2010;7(3):221-33.
2009: Paul L Boyer; B Christie Vu; Zandrea Ambrose; John G Julias; Svenja Warnecke; Chenzhong Liao; Chris Meier; Victor E Marquez; Stephen H Hughes
The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.
Journal of medicinal chemistry 2009;52(17):5356-64.
2009: Zandrea Ambrose; Brian D Herman; Chih-Wei Sheen; Shannon Zelina; Katie L Moore; Gilda Tachedjian; Dwight V Nissley; Nicolas Sluis-Cremer
The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs.
Journal of virology 2009;83(8):3826-33.
2009: Theodora Hatziioannou; Zandrea Ambrose; Nancy P-Y Chung; Michael Piatak; Fang Yuan; Charles M Trubey; Vicky Coalter; Rebecca Kiser; Doug Schneider; Jeremy Smedley; Rhonda Pung; Mercy Gathuka; Jacob D Estes; Ronald S Veazey; Vineet N KewalRamani; Jeffrey D Lifson; Paul D Bieniasz
A macaque model of HIV-1 infection.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4425-9.
2009: Wei Shao; Mary Kearney; Frank Maldarelli; John W Mellors; Robert M Stephens; Jeffrey D Lifson; Vineet N KewalRamani; Zandrea Ambrose; John M Coffin; Sarah E Palmer
RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy.
Retrovirology 2009;6():101.
2008: Zandrea Ambrose; Lara Compton; Michael Piatak; Ding Lu; W Gregory Alvord; Mariusz S Lubomirski; James E K Hildreth; Jeffrey D Lifson; Christopher J Miller; Vineet N KewalRamani
Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges.
Journal of virology 2008;82(13):6591-9.
2007: Zandrea Ambrose; Sarah Palmer; Valerie F Boltz; Mary Kearney; Kay Larsen; Patricia Polacino; Leon Flanary; Kelli Oswald; Michael Piatak; Jeremy Smedley; Wei Shao; Norbert Bischofberger; Frank Maldarelli; Jason T Kimata; John W Mellors; Shiu-Lok Hu; John M Coffin; Jeffrey D Lifson; Vineet N KewalRamani
Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy.
Journal of virology 2007;81(22):12145-55.
2007: Paul L Boyer; John G Julias; Zandrea Ambrose; Maqbool A Siddiqui; Victor E Marquez; Stephen H Hughes
The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants.
Journal of molecular biology 2007;371(4):873-82.
2007: Zandrea Ambrose; Vineet N KewalRamani; Paul D Bieniasz; Theodora Hatziioannou
HIV/AIDS: in search of an animal model.
Trends in biotechnology 2007;25(8):333-7.
2007: Dwight V Nissley; Jessica Radzio; Zandrea Ambrose; Chih-Wei Sheen; Noureddine Hamamouch; Katie L Moore; Gilda Tachedjian; Nicolas Sluis-Cremer
Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT.
The Biochemical journal 2007;404(1):151-7.
2006: Zandrea Ambrose; John G Julias; Paul L Boyer; Vineet N KewalRamani; Stephen H Hughes
The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine.
Journal of virology 2006;80(5):2578-81.
2004: Zandrea Ambrose; Valerie F Boltz; Sarah Palmer; John M Coffin; Stephen H Hughes; Vineet N KewalRamani
In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques.
Journal of virology 2004;78(24):13553-61.
2003: Zandrea Ambrose; Jannelle Thompson; Kay Larsen; Larene Kuller; Dennis Panicali; John Clements; Michael B Agy; David C Montefiori; Shiu-Lok Hu; Marnix Bosch
Evidence for immune-mediated reduction of viral replication in Macaca nemestrina mucosally immunized with inactivated SHIV(89.6).
Virology 2003;308(1):178-90.
2001: Zandrea Ambrose; Kay Larsen; Jannelle Thompson; Y Stevens; Eric E Finn; Shiu-Lok Hu; Marnix Bosch
Evidence for early local viral replication and local production of antiviral immunity upon mucosal simian-human immunodeficiency virus SHIV(89.6) infection in Macaca nemestrina.
Journal of virology 2001;75(18):8589-96.