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Christina Di Marco

Research Profile

Chemicals & Drugs

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Physiology

Allosteric Regulation

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TOP 3
Scott D Kuduk; Michael Leitl; Robert H Spencer; Mark O Urban; Matthew J Cato; Ronald K Chang; Sean P Cook; Christina N Di Marco; Robert M DiPardo; George D Hartman; Aneta Jovanovska; Stefanie A Kane; Mark T Bilodeau
Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3).
Scott D Kuduk; Lei Ma; Daniel R Pitts; Mark T Bilodeau; Ronald K Chang; Christina N Di Marco; Thomas J Greshock; George D Hartman; Kenneth A Koeplinger; Matthew A Seager; Charles D Thompson; Marion Wittmann; William J Ray
Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.
Scott D Kuduk; Christina N Di Marco; Victoria Cofre; William J Ray; Lei Ma; Marion Wittmann; Matthew A Seager; Kenneth A Koeplinger; Charles D Thompson; George D Hartman; Mark T Bilodeau
Fused heterocyclic M1 positive allosteric modulators.

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All Publications

2011: Scott D Kuduk; Michael Leitl; Robert H Spencer; Mark O Urban; Matthew J Cato; Ronald K Chang; Sean P Cook; Christina N Di Marco; Robert M DiPardo; George D Hartman; Aneta Jovanovska; Stefanie A Kane; Mark T Bilodeau
Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3).
Bioorganic & medicinal chemistry letters 2011;21(14):4255-8.
2011: Scott D Kuduk; Lei Ma; Daniel R Pitts; Mark T Bilodeau; Ronald K Chang; Christina N Di Marco; Thomas J Greshock; George D Hartman; Kenneth A Koeplinger; Matthew A Seager; Charles D Thompson; Marion Wittmann; William J Ray
Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.
Journal of medicinal chemistry 2011;54(13):4773-80.
2011: Scott D Kuduk; Christina N Di Marco; Victoria Cofre; William J Ray; Lei Ma; Marion Wittmann; Matthew A Seager; Kenneth A Koeplinger; Charles D Thompson; George D Hartman; Mark T Bilodeau
Fused heterocyclic M1 positive allosteric modulators.
Bioorganic & medicinal chemistry letters 2011;21(9):2769-72.
2011: Scott D Kuduk; Ronald K Chang; Christina N Di Marco; William J Ray; Lei Ma; Marion Wittmann; Matthew A Seager; Kenneth A Koeplinger; Charles D Thompson; George D Hartman; Mark T Bilodeau
Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.
Bioorganic & medicinal chemistry letters 2011;21(6):1710-5.
2010: Scott D Kuduk; Christina N Di Marco; Ronald K Chang; William J Ray; Lei Ma; Marion Wittmann; Matthew A Seager; Kenneth A Koeplinger; Charles D Thompson; George D Hartman; Mark T Bilodeau
Heterocyclic fused pyridone carboxylic acid M(1) positive allosteric modulators.
Bioorganic & medicinal chemistry letters 2010;20(8):2533-7.
2010: Scott D Kuduk; Christina N Di Marco; Victoria Cofre; Daniel R Pitts; William J Ray; Lei Ma; Marion Wittmann; Lone Veng; Matthew A Seager; Kenneth Koeplinger; Charles D Thompson; George D Hartman; Mark T Bilodeau
N-heterocyclic derived M1 positive allosteric modulators.
Bioorganic & medicinal chemistry letters 2010;20(4):1334-7.
2010: Scott D Kuduk; Michael Leitl; Annie Liang; Nova Sain; Robert H Spencer; Mark O Urban; Vera Bodmer-Narkevitch; Matthew J Cato; Sean P Cook; Christina N Di Marco; George D Hartman; Aneta Jovanovska; Stefanie A Kane; Mark T Bilodeau
Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567.
ACS chemical neuroscience 2010;1(1):19-24.
2010: Scott D Kuduk; Christina N Di Marco; Victoria Cofre; Daniel R Pitts; William J Ray; Lei Ma; Marion Wittmann; Matthew A Seager; Matthew Seager; Kenneth Koeplinger; Charles D Thompson; George D Hartman; Mark T Bilodeau
Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.
Bioorganic & medicinal chemistry letters 2010;20(2):657-61.
2009: Scott D Kuduk; Ronald K Chang; Jenny M-C Wai; Christina N Di Marco; Victoria Cofre; Robert M DiPardo; Sean P Cook; Matthew J Cato; Aneta Jovanovska; Mark O Urban; Michael Leitl; Robert H Spencer; Stefanie A Kane; George D Hartman; Mark T Bilodeau
Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Bioorganic & medicinal chemistry letters 2009;19(15):4059-63.
2009: Scott D Kuduk; Christina N Di Marco; Ronald K Chang; Robert M DiPardo; Sean P Cook; Matthew J Cato; Aneta Jovanovska; Mark O Urban; Michael Leitl; Robert H Spencer; Stefanie A Kane; Mark T Bilodeau; George D Hartman; Mark G Bock
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Bioorganic & medicinal chemistry letters 2009;19(9):2514-8.
2008: Scott D Kuduk; Ronald K Chang; Robert M DiPardo; Christina N Di Marco; Kathy L Murphy; Richard W Ransom; Duane R Reiss; Cuyue Tang; Thomayant Prueksaritanont; Douglas J Pettibone; Mark G Bock
Bradykinin B1 receptor antagonists: an alpha-hydroxy amide with an improved metabolism profile.
Bioorganic & medicinal chemistry letters 2008;18(18):5107-10.
2008: Cuyue Tang; Brian A Carr; Frédéric Poignant; Bennett Ma; Stacey L Polsky-Fisher; Yuhsin Kuo; Kristie Strong-Basalyga; Alisha Norcross; Karen Richards; Roy Eisenhandler; Edward J Carlini; Christina N Di Marco; Scott D Kuduk; Nathan X Yu; Conrad E Raab; Thomas H Rushmore; Clay B Frederick; Mark G Bock; Thomayant Prueksaritanont
CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2008;325(3):935-46.
2008: Dong-Mei Feng; Robert M DiPardo; Jenny M Wai; Ronald K Chang; Christina N Di Marco; Kathy L Murphy; Richard W Ransom; Duane R Reiss; Cuyue Tang; Thomayant Prueksaritanont; Douglas J Pettibone; Mark G Bock; Scott D Kuduk
A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity.
Bioorganic & medicinal chemistry letters 2008;18(2):682-7.
2008: Michael R Wood; Kathy M Schirripa; June J Kim; Scott D Kuduk; Ronald K Chang; Christina N Di Marco; Robert M DiPardo; Bang-Lin Wan; Kathy L Murphy; Richard W Ransom; Raymond S L Chang; Marie A Holahan; Jacquelynn J Cook; Wei Lemaire; Scott D Mosser; Rodney A Bednar; Cuyue Tang; Thomayant Prueksaritanont; Audrey A Wallace; Qin Mei; Jian Yu; Dennis Bohn; Franklin C Clayton; Emily D Adarayn; Gary R Sitko; Yvonne M Leonard; Roger M Freidinger; Douglas J Pettibone; Mark G Bock
Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists.
Bioorganic & medicinal chemistry letters 2008;18(2):716-20.
2007: Scott D Kuduk; Robert M DiPardo; Ronald K Chang; Christina N Di Marco; Kathy L Murphy; Richard W Ransom; Duane R Reiss; Cuyue Tang; Thomayant Prueksaritanont; Douglas J Pettibone; Mark G Bock
Bradykinin B1 antagonists: biphenyl SAR studies in the cyclopropanecarboxamide series.
Bioorganic & medicinal chemistry letters 2007;17(13):3608-12.
2007: Scott D Kuduk; Christina N Di Marco; Ronald K Chang; Michael R Wood; Kathy M Schirripa; June J Kim; Jenny M Wai; Robert M DiPardo; Kathy L Murphy; Richard W Ransom; Charles M Harrell; Duane R Reiss; Marie A Holahan; Jacquelynn Cook; J Fred Hess; Nova Sain; Mark O Urban; Cuyue Tang; Thomayant Prueksaritanont; Douglas J Pettibone; Mark G Bock
Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists.
Journal of medicinal chemistry 2007;50(2):272-82.
2006: Scott D Kuduk; Christina N Di Marco; Ronald K Chang; Michael R Wood; June J Kim; Kathy M Schirripa; Kathy L Murphy; Richard W Ransom; Cuyue Tang; Maricel Torrent; Sookhee Ha; Thomayant Prueksaritanont; Douglas J Pettibone; Mark G Bock
5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists.
Bioorganic & medicinal chemistry letters 2006;16(10):2791-5.