Vincenzo Di Marzo

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Clementina Manera; Giuseppe Saccomanni; Anna Maria Malfitano; Simone Bertini; Francesca Castelli; Chiara Laezza; Alessia Ligresti; Valentina Lucchesi; Tiziano Tuccinardi; Flavio Rizzolio; et al.
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold.
Angelo A Izzo; Raffaele Capasso; Gabriella Aviello; Francesca Borrelli; Barbara Romano; Fabiana Piscitelli; Laura Gallo; Francesco Capasso; Pierangelo Orlando; Vincenzo Di Marzo
Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice.
Giorgio Ortar; Ludovica Morera; Aniello Schiano Moriello; Enrico Morera; Marianna Nalli; Vincenzo Di Marzo; Luciano De Petrocellis
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.

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All Publications

2012: Clementina Manera; Giuseppe Saccomanni; Anna Maria Malfitano; Simone Bertini; Francesca Castelli; Chiara Laezza; Alessia Ligresti; Valentina Lucchesi; Tiziano Tuccinardi; Flavio Rizzolio; et al.
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold.
European journal of medicinal chemistry 2012;52():284-94.
2012: Angelo A Izzo; Raffaele Capasso; Gabriella Aviello; Francesca Borrelli; Barbara Romano; Fabiana Piscitelli; Laura Gallo; Francesco Capasso; Pierangelo Orlando; Vincenzo Di Marzo
Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice.
British journal of pharmacology 2012;166(4):1444-60.
2012: Giorgio Ortar; Ludovica Morera; Aniello Schiano Moriello; Enrico Morera; Marianna Nalli; Vincenzo Di Marzo; Luciano De Petrocellis
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.
Bioorganic & medicinal chemistry letters 2012;22(10):3535-9.
2012: Vincenzo Di Marzo
"De-liver-ance" From CB(1): A Way to Counteract Insulin Resistance?
Gastroenterology 2012;142(5):1063-6.
2012: Claudia Mugnaini; Stefania Nocerino; Valentina Pedani; Serena Pasquini; Andrea Tafi; Maria De Chiaro; Luca Bellucci; Massimo Valoti; Francesca Guida; Livio Luongo; et al.
Investigations on the 4-Quinolone-3-Carboxylic Acid Motif Part 5: Modulation of the Physicochemical Profile of a Set of Potent and Selective Cannabinoid-2 Receptor Ligands through a Bioisosteric Approach.
ChemMedChem 2012;7(5):920-34.
2012: Fabrizio Montecucco; Vincenzo Di Marzo; Rafaela F da Silva; Nicolas Vuilleumier; Luciano Capettini; Sébastien Lenglet; Sabrina Pagano; Fabiana Piscitelli; Silvia Quintao; Maria Bertolotto; et al.
The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques.
European heart journal 2012;33(7):846-56.
2012: Raffaele Capasso; Gabriella Aviello; Barbara Romano; Francesca Borrelli; Luciano De Petrocellis; Vincenzo Di Marzo; Angelo A Izzo
Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects.
British journal of pharmacology 2012;165(6):1966-77.
2012: Enrico Morera; Luciano De Petrocellis; Ludovica Morera; Aniello Schiano Moriello; Marianna Nalli; Vincenzo Di Marzo; Giorgio Ortar
Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.
Bioorganic & medicinal chemistry letters 2012;22(4):1674-7.
2012: Romina Nassini; Serena Materazzi; Joris Vriens; Jean Prenen; Silvia Benemei; Gaetano De Siena; Giancarlo la Marca; Eunice Andrè; Delia Preti; Cristina Avonto; et al.
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Brain : a journal of neurology 2012;135(Pt 2):376-90.
2012: L De Petrocellis; P Orlando; A Schiano Moriello; G Aviello; C Stott; A A Izzo; V Di Marzo
Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation.
Acta physiologica (Oxford, England) 2012;204(2):255-66.
2012: Luisa Gatta; Fabiana Piscitelli; Catia Giordano; Serena Boccella; Aron Lichtman; Sabatino Maione; Vincenzo Di Marzo
Discovery of prostamide F2α and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability.
PloS one 2012;7(2):e31111.
2011: Francesco Piscitelli; Alessia Ligresti; Giuseppe La Regina; Valerio Gatti; Antonella Brizzi; Serena Pasquini; Marco Allarà; Mauro Antonio Maria Carai; Ettore Novellino; Giancarlo Colombo; et al.
1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands.
European journal of medicinal chemistry 2011;46(11):5641-53.
2011: Federica Pollastro; Orazio Taglialatela-Scafati; Marco Allarà; Eduardo Muñoz; Vincenzo Di Marzo; Luciano De Petrocellis; Giovani Appendino
Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).
Journal of natural products 2011;74(9):2019-22.
2011: Elena Cichero; Alessia Ligresti; Marco Allarà; Vincenzo di Marzo; Zelda Lazzati; Pasqualina D'Ursi; Anna Marabotti; Luciano Milanesi; Andrea Spallarossa; Angelo Ranise; et al.
Homology modeling in tandem with 3D-QSAR analyses: a computational approach to depict the agonist binding site of the human CB2 receptor.
European journal of medicinal chemistry 2011;46(9):4489-505.
2011: Cristoforo Silvestri; Alessia Ligresti; Vincenzo Di Marzo
Peripheral effects of the endocannabinoid system in energy homeostasis: adipose tissue, liver and skeletal muscle.
Reviews in endocrine & metabolic disorders 2011;12(3):153-62.
2011: Serena Pasquini; Maria De Rosa; Valentina Pedani; Claudia Mugnaini; Francesca Guida; Livio Luongo; Maria De Chiaro; Sabatino Maione; Stefania Dragoni; Maria Frosini; et al.
Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice.
Journal of medicinal chemistry 2011;54(15):5444-53.
2011: Vincenzo Di Marzo
Endocannabinoids: an appetite for fat.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(31):12567-8.
2011: Luciano De Petrocellis; Alessia Ligresti; Aniello Schiano Moriello; Marco Allarà; Tiziana Bisogno; Stefania Petrosino; Colin G Stott; Vincenzo Di Marzo
Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.
British journal of pharmacology 2011;163(7):1479-94.
2011: V Di Marzo; F Piscitelli
Gut feelings about the endocannabinoid system.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2011;23(5):391-8.
2011: Francesca Rossi; Giulia Bellini; Livio Luongo; Marco Torella; Silvia Mancusi; Luciano De Petrocellis; Stefania Petrosino; Dario Siniscalco; Pierangelo Orlando; Mariantonietta Scafuro; et al.
The endovanilloid/endocannabinoid system: a new potential target for osteoporosis therapy.
Bone 2011;48(5):997-1007.
2011: Luciano De Petrocellis; Francesca Guida; Aniello Schiano Moriello; Maria De Chiaro; Fabiana Piscitelli; Vito de Novellis; Sabatino Maione; Vincenzo Di Marzo
N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;63(4):294-9.
2011: S Petrosino; B Ménard; N Zsürger; V Di Marzo; J Chabry
Alteration of the endocannabinoid system in mouse brain during prion disease.
Neuroscience 2011;177():292-7.
2011: Simone Brogi; Federico Corelli; Vincenzo Di Marzo; Alessia Ligresti; Claudia Mugnaini; Serena Pasquini; Andrea Tafi
Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.
European journal of medicinal chemistry 2011;46(2):547-55.
2011: Sabatino Maione; Fabiana Piscitelli; Luisa Gatta; Daniela Vita; Luciano De Petrocellis; Enza Palazzo; Vito de Novellis; Vincenzo Di Marzo
Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action.
British journal of pharmacology 2011;162(3):584-96.
2011: Cristina Avonto; Orazio Taglialatela-Scafati; Federica Pollastro; Alberto Minassi; Vincenzo Di Marzo; Luciano De Petrocellis; Giovanni Appendino
An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?
Angewandte Chemie (International ed. in English) 2011;50(2):467-71.
2011: Fabiana Piscitelli; Gianfranca Carta; Tiziana Bisogno; Elisabetta Murru; Lina Cordeddu; Kjetil Berge; Sally Tandy; Jeffrey S Cohn; Mikko Griinari; Sebastiano Banni; et al.
Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice.
Nutrition & metabolism 2011;8(1):51.
2011: Vincenzo Di Marzo; Fabiana Piscitelli; Raphael Mechoulam
Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes.
Handbook of experimental pharmacology 2011;(203):75-104.
2011: Sebastiano Banni; Gianfranca Carta; Elisabetta Murru; Lina Cordeddu; Elena Giordano; Anna Rita Sirigu; Kjetil Berge; Hogne Vik; Kevin C Maki; Vincenzo Di Marzo; et al.
Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects.
Nutrition & metabolism 2011;8(1):7.
2011: Vito de Novellis; Daniela Vita; Luisa Gatta; Livio Luongo; Giulia Bellini; Maria De Chiaro; Ida Marabese; Dario Siniscalco; Serena Boccella; Fabiana Piscitelli; et al.
The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats.
Molecular pain 2011;7():7.
2011: Vincenzo Di Marzo
Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight.
Nature neuroscience 2011;14(1):9-15.
2010: Romano Silvestri; Alessia Ligresti; Giuseppe La Regina; Francesco Piscitelli; Valerio Gatti; Antonio Lavecchia; Antonella Brizzi; Serena Pasquini; Marco Allarà; Noemi Fantini; et al.
Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.
European journal of medicinal chemistry 2010;45(12):5878-86.
2010: Tiziana Bisogno; Vincenzo Di Marzo
Cannabinoid receptors and endocannabinoids: role in neuroinflammatory and neurodegenerative disorders.
CNS & neurological disorders drug targets 2010;9(5):564-73.
2010: Giorgio Ortar; Luciano De Petrocellis; Ludovica Morera; Aniello Schiano Moriello; Pierangelo Orlando; Enrico Morera; Marianna Nalli; Vincenzo Di Marzo
(-)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels.
Bioorganic & medicinal chemistry letters 2010;20(9):2729-32.
2010: D De Filippis; A D'Amico; M Cipriano; S Petrosino; P Orlando; V Di Marzo; T Iuvone
Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats.
Pharmacological research : the official journal of the Italian Pharmacological Society 2010;61(4):321-8.
2010: Luciano De Petrocellis; Vincenzo Di Marzo
Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2010;5(1):103-21.
2010: Gilda Cobellis; Giulia Ricci; Giovanna Cacciola; Pierangelo Orlando; Stefania Petrosino; Maria Grazia Cascio; Tiziana Bisogno; Luciano De Petrocellis; Teresa Chioccarelli; Lucia Altucci; et al.
A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up.
Biology of reproduction 2010;82(2):451-8.
2010: Giovanni Annuzzi; Fabiana Piscitelli; Lucrezia Di Marino; Lidia Patti; Rosalba Giacco; Giuseppina Costabile; Lutgarda Bozzetto; Gabriele Riccardi; Roberta Verde; Stefania Petrosino; et al.
Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients.
Lipids in health and disease 2010;9():43.
2010: Stefania Petrosino; Vincenzo Di Marzo
FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels.
Current opinion in investigational drugs (London, England : 2000) 2010;11(1):51-62.
2010: Sebastiano Banni; Vincenzo Di Marzo
Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood.
Molecular nutrition & food research 2010;54(1):82-92.
2010: Giovanni Appendino; Abdellah Ech-Chahad; Alberto Minassi; Luciano De Petrocellis; Vincenzo Di Marzo
Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene.
Bioorganic & medicinal chemistry letters 2010;20(1):97-9.
2010: F Loría; S Petrosino; M Hernangómez; L Mestre; A Spagnolo; F Correa; V Di Marzo; F Docagne; C Guaza
An endocannabinoid tone limits excitotoxicity in vitro and in a model of multiple sclerosis.
Neurobiology of disease 2010;37(1):166-76.
2010: Angelo A Izzo; Fabiana Piscitelli; Raffaele Capasso; Pietro Marini; Luigia Cristino; Stefania Petrosino; Vincenzo Di Marzo
Basal and fasting/refeeding-regulated tissue levels of endogenous PPAR-alpha ligands in Zucker rats.
Obesity (Silver Spring, Md.) 2010;18(1):55-62.
2009: Enrico Morera; Luciano De Petrocellis; Ludovica Morera; Aniello Schiano Moriello; Alessia Ligresti; Marianna Nalli; David F Woodward; Vincenzo Di Marzo; Giorgio Ortar
Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.
Bioorganic & medicinal chemistry letters 2009;19(23):6806-9.
2009: Vincenzo Di Marzo; Jean-Pierre Després
CB1 antagonists for obesity--what lessons have we learned from rimonabant?
Nature reviews. Endocrinology 2009;5(11):633-8.
2009: Vincenzo Di Marzo; An Verrijken; Antti Hakkarainen; Stefania Petrosino; Ilse Mertens; Nina Lundbom; Fabiana Piscitelli; Jukka Westerbacka; Aino Soro-Paavonen; Isabel Matias; et al.
Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects.
European journal of endocrinology / European Federation of Endocrine Societies 2009;161(5):715-22.
2009: Francesca Borrelli; Gabriella Aviello; Barbara Romano; Pierangelo Orlando; Raffaele Capasso; Francesco Maiello; Federico Guadagno; Stefania Petrosino; Francesco Capasso; Vincenzo Di Marzo; et al.
Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis.
Journal of molecular medicine (Berlin, Germany) 2009;87(11):1111-21.
2009: Angelo A Izzo; Francesca Borrelli; Raffaele Capasso; Vincenzo Di Marzo; Raphael Mechoulam
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
Trends in pharmacological sciences 2009;30(10):515-27.
2009: Vincenzo Micale; Luigia Cristino; Alessandra Tamburella; Stefania Petrosino; Gian Marco Leggio; Filippo Drago; Vincenzo Di Marzo
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.
Neurobiology of disease 2009;36(1):70-80.
2009: Serena Pasquini; Claudia Mugnaini; Antonella Brizzi; Alessia Ligresti; Vincenzo Di Marzo; Chiara Ghiron; Federico Corelli
Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N-alkylacetamides as CB2 receptor ligands.
Journal of combinatorial chemistry 2009;11(5):795-8.
2009: Angelo A Izzo; Fabiana Piscitelli; Raffaele Capasso; Gabriella Aviello; Barbara Romano; Francesca Borrelli; Stefania Petrosino; Vincenzo Di Marzo
Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding.
British journal of pharmacology 2009;158(2):451-61.
2009: Vincenzo Di Marzo
The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation.
Pharmacological research : the official journal of the Italian Pharmacological Society 2009;60(2):77-84.
2009: Barbara Batetta; Mikko Griinari; Gianfranca Carta; Elisabetta Murru; Alessia Ligresti; Lina Cordeddu; Elena Giordano; Francesca Sanna; Tiziana Bisogno; Sabrina Uda; et al.
Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats.
The Journal of nutrition 2009;139(8):1495-501.
2009: Pietro Marini; Aniello Schiano Moriello; Luigia Cristino; Maura Palmery; Luciano De Petrocellis; Vincenzo Di Marzo
Cannabinoid CB1 receptor elevation of intracellular calcium in neuroblastoma SH-SY5Y cells: interactions with muscarinic and delta-opioid receptors.
Biochimica et biophysica acta 2009;1793(7):1289-303.
2009: Clementina Manera; Giuseppe Saccomanni; Barbara Adinolfi; Veronica Benetti; Alessia Ligresti; Maria Grazia Cascio; Tiziano Tuccinardi; Valentina Lucchesi; Adriano Martinelli; Paola Nieri; et al.
Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists.
Journal of medicinal chemistry 2009;52(12):3644-51.
2009: V Di Marzo; A Ligresti; L Cristino
The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation.
International journal of obesity (2005) 2009;33 Suppl 2():S18-24.
2009: Alessia Ligresti; Stefania Petrosino; Vincenzo Di Marzo
From endocannabinoid profiling to 'endocannabinoid therapeutics'.
Current opinion in chemical biology 2009;13(3):321-31.
2009: Stefania Petrosino; Alessia Ligresti; Vincenzo Di Marzo
Endocannabinoid chemical biology: a tool for the development of novel therapies.
Current opinion in chemical biology 2009;13(3):309-20.
2009: Sabatino Maione; Luigia Cristino; Anna Lucia Migliozzi; Anne L Georgiou; Katarzyna Starowicz; Thomas E Salt; Vincenzo Di Marzo
TRPV1 channels control synaptic plasticity in the developing superior colliculus.
The Journal of physiology 2009;587(Pt 11):2521-35.
2009: Luciano De Petrocellis; Vincenzo Di Marzo
Role of endocannabinoids and endovanilloids in Ca2+ signalling.
Cell calcium 2009;45(6):611-24.
2009: Tiziana Bisogno; James J Burston; Ravi Rai; Marco Allarà; Bijali Saha; Anu Mahadevan; Raj K Razdan; Jenny L Wiley; Vincenzo Di Marzo
Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.
ChemMedChem 2009;4(6):946-50.
2009: Giovanni Appendino; Alessia Ligresti; Alberto Minassi; Maria Grazia Cascio; Marco Allarà; Orazio Taglialatela-Scafati; Roger G Pertwee; Luciano De Petrocellis; Vincenzo Di Marzo
Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes.
Journal of medicinal chemistry 2009;52(9):3001-9.
2009: Sabatino Maione; Katarzyna Starowicz; Luigia Cristino; Francesca Guida; Enza Palazzo; Livio Luongo; Francesca Rossi; Ida Marabese; Vito de Novellis; Vincenzo Di Marzo
Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia.
Journal of neurophysiology 2009;101(5):2411-22.
2009: Antonella Brizzi; Vittorio Brizzi; Maria Grazia Cascio; Federico Corelli; Francesca Guida; Alessia Ligresti; Sabatino Maione; Adriano Martinelli; Serena Pasquini; Tiziano Tuccinardi; et al.
New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo.
Journal of medicinal chemistry 2009;52(8):2506-14.
2009: Erika Cottone; Alda Guastalla; Valentina Pomatto; Ezio Campantico; Vincenzo Di Marzo; Mariafosca Franzoni
Goldfish CB1 mRNA expression is affected by fasting and anandamide administration.
Neuroreport 2009;20(6):595-9.
2009: L De Petrocellis; R Deva; F Mainieri; M Schaefer; T Bisogno; R Ciccoli; A Ligresti; K Hill; S Nigam; G Appendino; et al.
Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide.
Journal of lipid research 2009;50(4):658-66.
2009: F Rossi; D Siniscalco; L Luongo; L De Petrocellis; G Bellini; S Petrosino; M Torella; C Santoro; B Nobili; S Perrotta; et al.
The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption.
Bone 2009;44(3):476-84.
2009: Luciano De Petrocellis; Vincenzo Di Marzo
An introduction to the endocannabinoid system: from the early to the latest concepts.
Best practice & research. Clinical endocrinology & metabolism 2009;23(1):1-15.
2009: Vincenzo Di Marzo
The endocannabinoid system in metabolic control: a preface.
Best practice & research. Clinical endocrinology & metabolism 2009;23(1):vii-ix.
2009: V Di Marzo; M Côté; I Matias; I Lemieux; B J Arsenault; A Cartier; F Piscitelli; S Petrosino; N Alméras; J-P Després
Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors.
Diabetologia 2009;52(2):213-7.
2009: Vincenzo Micale; Luigia Cristino; Alessandra Tamburella; Stefania Petrosino; Gian Marco Leggio; Filippo Drago; Vincenzo Di Marzo
Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(3):593-606.
2008: Vincenzo Di Marzo; Gabriella Gobbi; Arpad Szallasi
Brain TRPV1: a depressing TR(i)P down memory lane?
Trends in pharmacological sciences 2008;29(12):594-600.
2008: Vincenzo Di Marzo
CB(1) receptor antagonism: biological basis for metabolic effects.
Drug discovery today 2008;13(23-24):1026-41.
2008: Vito de Novellis; Enza Palazzo; Francesca Rossi; Luciano De Petrocellis; Stefania Petrosino; Francesca Guida; Livio Luongo; Annalucia Migliozzi; Luigia Cristino; Ida Marabese; et al.
The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats.
Neuropharmacology 2008;55(7):1105-13.
2008: Vittorio Vellani; Stefania Petrosino; Luciano De Petrocellis; Marta Valenti; Massimiliano Prandini; Pier Cosimo Magherini; Peter A McNaughton; Vincenzo Di Marzo
Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin.
Neuropharmacology 2008;55(8):1274-9.
2008: Giorgio Ortar; Tiziana Bisogno; Alessia Ligresti; Enrico Morera; Marianna Nalli; Vincenzo Di Marzo
Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism.
Journal of medicinal chemistry 2008;51(21):6970-9.
2008: S Maione; E Morera; I Marabese; A Ligresti; L Luongo; G Ortar; V Di Marzo
Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms.
British journal of pharmacology 2008;155(5):775-82.
2008: R Capasso; F Borrelli; M G Cascio; G Aviello; K Huben; J K Zjawiony; P Marini; B Romano; V Di Marzo; F Capasso; et al.
Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors.
British journal of pharmacology 2008;155(5):681-9.
2008: M López-Gallardo; R Llorente; A Llorente-Berzal; E M Marco; C Prada; V Di Marzo; M P Viveros
Neuronal and glial alterations in the cerebellar cortex of maternally deprived rats: gender differences and modulatory effects of two inhibitors of endocannabinoid inactivation.
Developmental neurobiology 2008;68(12):1429-40.
2008: Vincenzo Di Marzo
Play an ADAGIO with a STRADIVARIUS: the right patient for CB1 receptor antagonists?
Nature clinical practice. Cardiovascular medicine 2008;5(10):610-2.
2008: Ricardo Llorente; Alvaro Llorente-Berzal; Stefania Petrosino; Eva-María Marco; Carmen Guaza; Carmen Prada; Meritxell López-Gallardo; Vincenzo Di Marzo; María-Paz Viveros
Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system.
Developmental neurobiology 2008;68(11):1334-47.
2008: Serena Pasquini; Lorenzo Botta; Teresa Semeraro; Claudia Mugnaini; Alessia Ligresti; Enza Palazzo; Sabatino Maione; Vincenzo Di Marzo; Federico Corelli
Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo.
Journal of medicinal chemistry 2008;51(16):5075-84.
2008: Frida Loría; Stefania Petrosino; Leyre Mestre; Alessandra Spagnolo; Fernando Correa; Miriam Hernangómez; Carmen Guaza; Vincenzo Di Marzo; Fabian Docagne
Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide.
The European journal of neuroscience 2008;28(4):633-41.
2008: Jan Mulder; Tania Aguado; Erik Keimpema; Klaudia Barabás; Carlos J Ballester Rosado; Laurent Nguyen; Krisztina Monory; Giovanni Marsicano; Vincenzo Di Marzo; Yasmin L Hurd; et al.
Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8760-5.
2008: Luciano De Petrocellis; Vittorio Vellani; Aniello Schiano-Moriello; Pietro Marini; Pier Cosimo Magherini; Pierangelo Orlando; Vincenzo Di Marzo
Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8.
The Journal of pharmacology and experimental therapeutics 2008;325(3):1007-15.
2008: T Rubino; N Realini; C Castiglioni; C Guidali; D Viganó; E Marras; S Petrosino; G Perletti; M Maccarrone; V Di Marzo; et al.
Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex.
Cerebral cortex (New York, N.Y. : 1991) 2008;18(6):1292-301.
2008: Vincenzo Di Marzo
Targeting the endocannabinoid system: to enhance or reduce?
Nature reviews. Drug discovery 2008;7(5):438-55.
2008: Giorgio Ortar; Aniello Schiano Moriello; Maria Grazia Cascio; Luciano De Petrocellis; Alessia Ligresti; Enrico Morera; Marianna Nalli; Vincenzo Di Marzo
New tetrazole-based selective anandamide uptake inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(9):2820-4.
2008: Vincenzo Di Marzo; Mauro Maccarrone
FAAH and anandamide: is 2-AG really the odd one out?
Trends in pharmacological sciences 2008;29(5):229-33.
2008: Gunnar Thiemann; Vincenzo Di Marzo; Areles Molleman; Rüdiger U Hasenöhrl
The CB(1) cannabinoid receptor antagonist AM251 attenuates amphetamine-induced behavioural sensitization while causing monoamine changes in nucleus accumbens and hippocampus.
Pharmacology, biochemistry, and behavior 2008;89(3):384-91.
2008: Isabel Matias; Stefania Petrosino; Alessandro Racioppi; Raffaele Capasso; Angelo A Izzo; Vincenzo Di Marzo
Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets.
Molecular and cellular endocrinology 2008;286(1-2 Suppl 1):S66-78.
2008: Gabriella Aviello; Isabel Matias; Raffaele Capasso; Stefania Petrosino; Francesca Borrelli; Pierangelo Orlando; Barbara Romano; Francesco Capasso; Vincenzo Di Marzo; Angelo A Izzo
Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice.
Journal of molecular medicine (Berlin, Germany) 2008;86(4):413-22.
2008: Romano Silvestri; Maria Grazia Cascio; Giuseppe La Regina; Francesco Piscitelli; Antonio Lavecchia; Antonella Brizzi; Serena Pasquini; Maurizio Botta; Ettore Novellino; Vincenzo Di Marzo; et al.
Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides.
Journal of medicinal chemistry 2008;51(6):1560-76.
2008: Gunnar Thiemann; Mario van der Stelt; Stefania Petrosino; Areles Molleman; Vincenzo Di Marzo; Rüdiger U Hasenöhrl
The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization.
Behavioural brain research 2008;187(2):289-96.
2008: Katarzyna M Starowicz; Luigia Cristino; Isabel Matias; Raffaele Capasso; Alessandro Racioppi; Angelo A Izzo; Vincenzo Di Marzo
Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet.
Obesity (Silver Spring, Md.) 2008;16(3):553-65.
2008: V Di Marzo; R Capasso; I Matias; G Aviello; S Petrosino; F Borrelli; B Romano; P Orlando; F Capasso; A A Izzo
The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet.
British journal of pharmacology 2008;153(6):1272-80.
2008: L Cristino; K Starowicz; L De Petrocellis; J Morishita; N Ueda; V Guglielmotti; V Di Marzo
Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain.
Neuroscience 2008;151(4):955-68.
2008: Vincenzo Di Marzo; Luigia Cristino
Why endocannabinoids are not all alike.
Nature neuroscience 2008;11(2):124-6.
2008: Tiziana Bisogno; Vincenzo Di Marzo
The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses.
Current pharmaceutical design 2008;14(23):2299-3305.
2008: V Di Marzo
Endocannabinoids: synthesis and degradation.
Reviews of physiology, biochemistry and pharmacology 2008;160():1-24.
2008: Katarzyna Starowicz; Luigia Cristino; Vincenzo Di Marzo
TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications.
Current pharmaceutical design 2008;14(1):42-54.
2008: Vincenzo Di Marzo; Katarzyna Starowicz
New Potential Therapies from Vanilloid Transient Receptor Cation (TRPV) Channels.
Current pharmaceutical design 2008;14(1):1.
2008: Isabel Matias; Gianfranca Carta; Elisabetta Murru; Stefania Petrosino; Sebastiano Banni; Vincenzo Di Marzo
Effect of polyunsaturated fatty acids on endocannabinoid and N-acyl-ethanolamine levels in mouse adipocytes.
Biochimica et biophysica acta 2008;1781(1-2):52-60.
2008: Angelo A Izzo; Gabriella Aviello; Stefania Petrosino; Pierangelo Orlando; Giovanni Marsicano; Beat Lutz; Francesca Borrelli; Raffaele Capasso; Santosh Nigam; Francesco Capasso; et al.
Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon.
Journal of molecular medicine (Berlin, Germany) 2008;86(1):89-98.
2008: Joseph Tam; Victoria Trembovler; Vincenzo Di Marzo; Stefania Petrosino; Gabriella Leo; Alex Alexandrovich; Eran Regev; Nardy Casap; Arie Shteyer; Catherine Ledent; et al.
The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(1):285-94.
2008: Isabel Matias; Anna Valeria Vergoni; Stefania Petrosino; Alessandra Ottani; Alessandro Pocai; Alfio Bertolini; Vincenzo Di Marzo
Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: insulin and melanocortins.
Neuropharmacology 2008;54(1):206-12.
2008: Tiziana Bisogno; Alberto Martire; Stefania Petrosino; Patrizia Popoli; Vincenzo Di Marzo
Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease.
Neurochemistry international 2008;52(1-2):307-13.
2008: Giorgio Ortar; Maria Grazia Cascio; Aniello Schiano Moriello; Mercedes Camalli; Enrico Morera; Marianna Nalli; Vincenzo Di Marzo
Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.
European journal of medicinal chemistry 2008;43(1):62-72.
2007: Giorgio Ortar; Maria Grazia Cascio; Luciano De Petrocellis; Enrico Morera; Francesca Rossi; Aniello Schiano-Moriello; Marianna Nalli; Vito de Novellis; David F Woodward; Sabatino Maione; et al.
New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain.
Journal of medicinal chemistry 2007;50(26):6554-69.
2007: Katarzyna Starowicz; Sabatino Maione; Luigia Cristino; Enza Palazzo; Ida Marabese; Francesca Rossi; Vito de Novellis; Vincenzo Di Marzo
Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(50):13739-49.
2007: Carmela Della Monica; Luciano De Petrocellis; Vincenzo Di Marzo; Raffaella Landi; Irene Izzo; Aldo Spinella
Enantioselective synthesis and vanilloid activity evaluation of 1-beta-(p-methoxycinnamoyl)polygodial, an antinociceptive compound from Drymis winteri barks.
Bioorganic & medicinal chemistry letters 2007;17(23):6444-7.
2007: Clementina Manera; Maria Grazia Cascio; Veronica Benetti; Marco Allarà; Tiziano Tuccinardi; Adriano Martinelli; Giuseppe Saccomanni; Elisa Vivoli; Carla Ghelardini; Vincenzo Di Marzo; et al.
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.
Bioorganic & medicinal chemistry letters 2007;17(23):6505-10.
2007: Teresa Iuvone; Giuseppe Esposito; Daniele De Filippis; Tiziana Bisogno; Stefania Petrosino; Caterina Scuderi; Vincenzo Di Marzo; Luca Steardo;
Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro.
Journal of molecular medicine (Berlin, Germany) 2007;85(12):1379-92.
2007: Tiziana Bisogno; Vincenzo Di Marzo
Short- and long-term plasticity of the endocannabinoid system in neuropsychiatric and neurological disorders.
Pharmacological research : the official journal of the Italian Pharmacological Society 2007;56(5):428-42.
2007: I Matias; M-P Gonthier; S Petrosino; L Docimo; R Capasso; L Hoareau; P Monteleone; R Roche; A A Izzo; V Di Marzo
Role and regulation of acylethanolamides in energy balance: focus on adipocytes and beta-cells.
British journal of pharmacology 2007;152(5):676-90.
2007: F Minutolo; M G Cascio; I Carboni; T Bisogno; G Prota; S Bertini; M Digiacomo; M Bifulco; V Di Marzo; M Macchia
Metabolically labile cannabinoid esters: a 'soft drug' approach for the development of cannabinoid-based therapeutic drugs.
Bioorganic & medicinal chemistry letters 2007;17(17):4878-81.
2007: Giuseppe Esposito; Teresa Iuvone; Claudia Savani; Caterina Scuderi; Daniele De Filippis; Michele Papa; Vincenzo Di Marzo; Luca Steardo
Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence.
The Journal of pharmacology and experimental therapeutics 2007;322(3):1144-52.
2007: Luciano De Petrocellis; Pietro Marini; Isabel Matias; Aniello Schiano Moriello; Katarzyna Starowicz; Luigia Cristino; Santosh Nigam; Vincenzo Di Marzo
Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells.
Experimental cell research 2007;313(14):2993-3004.
2007: Antonella Brizzi; Maria Grazia Cascio; Vittorio Brizzi; Tiziana Bisogno; Maria Teresa Dinatolo; Adriano Martinelli; Tiziano Tuccinardi; Vincenzo Di Marzo
Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors.
Bioorganic & medicinal chemistry 2007;15(16):5406-16.
2007: Jeffery J Prusakiewicz; Melissa V Turman; Andrew Vila; Heather L Ball; Ahmad H Al-Mestarihi; Vincenzo Di Marzo; Lawrence J Marnett
Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.
Archives of biochemistry and biophysics 2007;464(2):260-8.
2007: E Soria-Gómez; I Matias; P E Rueda-Orozco; M Cisneros; S Petrosino; L Navarro; V Di Marzo; O Prospéro-García
Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus.
British journal of pharmacology 2007;151(7):1109-16.
2007: Vincenzo Di Marzo; Tiziana Bisogno; Luciano De Petrocellis
Endocannabinoids and related compounds: walking back and forth between plant natural products and animal physiology.
Chemistry & biology 2007;14(7):741-56.
2007: Ida Marabese; Francesca Rossi; Enza Palazzo; Vito de Novellis; Katarzyna Starowicz; Luigia Cristino; Daniela Vita; Luisa Gatta; Francesca Guida; Vincenzo Di Marzo; et al.
Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception.
Journal of neurophysiology 2007;98(1):43-53.
2007: Meliha Karsak; Evelyn Gaffal; Rahul Date; Lihua Wang-Eckhardt; Jennifer Rehnelt; Stefania Petrosino; Katarzyna Starowicz; Regina Steuder; Eberhard Schlicker; Benjamin Cravatt; et al.
Attenuation of allergic contact dermatitis through the endocannabinoid system.
Science (New York, N.Y.) 2007;316(5830):1494-7.
2007: Luciano De Petrocellis; Katarzyna Starowicz; Aniello Schiano Moriello; Marta Vivese; Pierangelo Orlando; Vincenzo Di Marzo
Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids.
Experimental cell research 2007;313(9):1911-20.
2007: K A Sharkey; L Cristino; L D Oland; M D Van Sickle; K Starowicz; Q J Pittman; V Guglielmotti; J S Davison; V Di Marzo
Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret.
The European journal of neuroscience 2007;25(9):2773-82.
2007: Giuseppe D'Argenio; Stefania Petrosino; Carmen Gianfrani; Marta Valenti; Giuseppe Scaglione; Ilenia Grandone; Santosh Nigam; Italo Sorrentini; Giuseppe Mazzarella; Vincenzo Di Marzo
Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats.
Journal of molecular medicine (Berlin, Germany) 2007;85(5):523-30.
2007: Marie-Paule Gonthier; Laurence Hoareau; Franck Festy; Isabel Matias; Marta Valenti; Sandrine Bès-Houtmann; Claude Rouch; Christine Robert-Da Silva; Serge Chesne; Christian Lefebvre d'Hellencourt; et al.
Identification of endocannabinoids and related compounds in human fat cells.
Obesity (Silver Spring, Md.) 2007;15(4):837-45.
2007: Vincenzo Di Marzo; Stefania Petrosino
Endocannabinoids and the regulation of their levels in health and disease.
Current opinion in lipidology 2007;18(2):129-40.
2007: Katarzyna Starowicz; Santosh Nigam; Vincenzo Di Marzo
Biochemistry and pharmacology of endovanilloids.
Pharmacology & therapeutics 2007;114(1):13-33.
2007: M Côté; I Matias; I Lemieux; S Petrosino; N Alméras; J-P Després; V Di Marzo
Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men.
International journal of obesity (2005) 2007;31(4):692-9.
2007: S Maione; L De Petrocellis; V de Novellis; A Schiano Moriello; S Petrosino; E Palazzo; F Sca Rossi; D F Woodward; V Di Marzo
Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.
British journal of pharmacology 2007;150(6):766-81.
2007: Stefania Petrosino; Enza Palazzo; Vito de Novellis; Tiziana Bisogno; Francesco Rossi; Sabatino Maione; Vincenzo Di Marzo
Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats.
Neuropharmacology 2007;52(2):415-22.
2007: Silvia Marinelli; Vincenzo Di Marzo; Fulvio Florenzano; Filomena Fezza; Maria Teresa Viscomi; Mario van der Stelt; Giorgio Bernardi; Marco Molinari; Mauro Maccarrone; Nicola B Mercuri
N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(2):298-308.
2007: Giovanni Appendino; Sara Bacchiega; Alberto Minassi; Maria Grazia Cascio; Luciano De Petrocellis; Vincenzo Di Marzo
The 1,2,3-triazole ring as a peptido- and olefinomimetic element: discovery of click vanilloids and cannabinoids.
Angewandte Chemie (International ed. in English) 2007;46(48):9312-5.
2007: Isabel Matias; Vincenzo Di Marzo
Endocannabinoids and the control of energy balance.
Trends in endocrinology and metabolism: TEM 2007;18(1):27-37.
2007: Giovanni Appendino; Abdellah Ech-Chahad; Alberto Minassi; Sara Bacchiega; Luciano De Petrocellis; Vincenzo Di Marzo
Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): the homovanillyl moiety.
Bioorganic & medicinal chemistry letters 2007;17(1):132-5.
2006: I Matias; J W Wang; A Schiano Moriello; A Nieves; D F Woodward; V Di Marzo
Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration.
Prostaglandins, leukotrienes, and essential fatty acids 2006;75(6):413-8.
2006: Bela Szabo; Michal J Urbanski; Tiziana Bisogno; Vincenzo Di Marzo; Aitziber Mendiguren; Wolfram U Baer; Ilka Freiman
Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol.
The Journal of physiology 2006;577(Pt 1):263-80.
2006: Enza Palazzo; Vito de Novellis; Stefania Petrosino; Ida Marabese; Daniela Vita; Catia Giordano; Vincenzo Di Marzo; Giuseppe Salvatore Mangoni; Francesco Rossi; Sabatino Maione
Neuropathic pain and the endocannabinoid system in the dorsal raphe: pharmacological treatment and interactions with the serotonergic system.
The European journal of neuroscience 2006;24(7):2011-20.
2006: M G Cascio; T Bisogno; E Palazzo; A Thomas; M van der Stelt; A Brizzi; V de Novellis; I Marabese; R Ross; T van de Doelen; et al.
In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands.
British journal of pharmacology 2006;149(4):431-40.
2006: Miriam Melis; Giuliano Pillolla; Tiziana Bisogno; Alberto Minassi; Stefania Petrosino; Simona Perra; Anna Lisa Muntoni; Beat Lutz; Gian Luigi Gessa; Giovanni Marsicano; et al.
Protective activation of the endocannabinoid system during ischemia in dopamine neurons.
Neurobiology of disease 2006;24(1):15-27.
2006: Joohyung Lee; Vincenzo Di Marzo; Jonathan M Brotchie
A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats.
Neuropharmacology 2006;51(3):557-65.
2006: Alessia Ligresti; Aniello Schiano Moriello; Katarzyna Starowicz; Isabel Matias; Simona Pisanti; Luciano De Petrocellis; Chiara Laezza; Giuseppe Portella; Maurizio Bifulco; Vincenzo Di Marzo
Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma.
The Journal of pharmacology and experimental therapeutics 2006;318(3):1375-87.
2006: Maria Di Marzo; Agostino Casapullo; Giuseppe Bifulco; Paola Cimino; Alessia Ligresti; Vincenzo Di Marzo; Raffaele Riccio; Luigi Gomez-Paloma
Synthesis, conformational analysis and CB1 binding affinity of hairpin-like anandamide pseudopeptide mimetics.
Journal of peptide science : an official publication of the European Peptide Society 2006;12(9):575-91.
2006: Nina Wettschureck; Mario van der Stelt; Hiroshi Tsubokawa; Heinz Krestel; Alexandra Moers; Stefania Petrosino; Günther Schütz; Vincenzo Di Marzo; Stefan Offermanns
Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation.
Molecular and cellular biology 2006;26(15):5888-94.
2006: Isabel Matias; Marie-Paule Gonthier; Pierangelo Orlando; Vassilis Martiadis; Luciano De Petrocellis; Cristina Cervino; Stefania Petrosino; Laurence Hoareau; Franck Festy; Renato Pasquali; et al.
Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia.
The Journal of clinical endocrinology and metabolism 2006;91(8):3171-80.
2006: Laurence Balas; Maria Grazia Cascio; Vincenzo Di Marzo; Thierry Durand
Synthesis of a potential photoactivatable anandamide analog.
Bioorganic & medicinal chemistry letters 2006;16(14):3765-8.
2006: Kornelia Kamprath; Giovanni Marsicano; Jianrong Tang; Krisztina Monory; Tiziana Bisogno; Vincenzo Di Marzo; Beat Lutz; Carsten T Wotjak
Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(25):6677-86.
2006: M van der Stelt; C Mazzola; G Esposito; I Matias; S Petrosino; D De Filippis; V Micale; L Steardo; F Drago; T Iuvone; et al.
Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels.
Cellular and molecular life sciences : CMLS 2006;63(12):1410-24.
2006: Lynsey G Bilsland; James R T Dick; Gareth Pryce; Stefania Petrosino; Vincenzo Di Marzo; David Baker; Linda Greensmith
Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):1003-5.
2006: Giovanni Appendino; Alberto Minassi; Luca Berton; Aniello Schiano Moriello; Maria Grazia Cascio; Luciano De Petrocellis; Vincenzo Di Marzo
Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity.
Journal of medicinal chemistry 2006;49(7):2333-8.
2006: Aniello Schiano Moriello; Laurence Balas; Alessia Ligresti; Maria Grazia Cascio; Thierry Durand; Enrico Morera; Giorgio Ortar; Vincenzo Di Marzo
Development of the first potential covalent inhibitors of anandamide cellular uptake.
Journal of medicinal chemistry 2006;49(7):2320-32.
2006: R Mechoulam; E M Berry; Y Avraham; V Di Marzo; E Fride
Endocannabinoids, feeding and suckling--from our perspective.
International journal of obesity (2005) 2006;30 Suppl 1():S24-8.
2006: Nieves Márquez; Luciano De Petrocellis; Francisco J Caballero; Antonio Macho; Aniello Schiano-Moriello; Alberto Minassi; Giovanni Appendino; Eduardo Muñoz; Vincenzo Di Marzo
Iodinated N-acylvanillamines: potential "multiple-target" anti-inflammatory agents acting via the inhibition of t-cell activation and antagonism at vanilloid TRPV1 channels.
Molecular pharmacology 2006;69(4):1373-82.
2006: John M McPartland; Isabel Matias; Vincenzo Di Marzo; Michelle Glass
Evolutionary origins of the endocannabinoid system.
Gene 2006;370():64-74.
2006: Eleni T Tzavara; Dominic L Li; Larissa Moutsimilli; Tiziana Bisogno; Vincenzo Di Marzo; Lee A Phebus; George G Nomikos; Bruno Giros
Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implications.
Biological psychiatry 2006;59(6):508-15.
2006: Vincenzo Di Marzo
A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists.
Trends in pharmacological sciences 2006;27(3):134-40.
2006: Giuseppe D'Argenio; Marta Valenti; Giuseppe Scaglione; Vittorio Cosenza; Italo Sorrentini; Vincenzo Di Marzo
Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):568-70.
2006: Sabatino Maione; Tiziana Bisogno; Vito de Novellis; Enza Palazzo; Luigia Cristino; Marta Valenti; Stefania Petrosino; Vittorio Guglielmotti; Francesco Rossi; Vincenzo Di Marzo
Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors.
The Journal of pharmacology and experimental therapeutics 2006;316(3):969-82.
2006: Claudia Grimaldi; Simona Pisanti; Chiara Laezza; Anna Maria Malfitano; Antonietta Santoro; Mario Vitale; Maria Gabriella Caruso; Maria Notarnicola; Irma Iacuzzo; Giuseppe Portella; et al.
Anandamide inhibits adhesion and migration of breast cancer cells.
Experimental cell research 2006;312(4):363-73.
2006: Tiziana Bisogno; Maria Grazia Cascio; Bijali Saha; Anu Mahadevan; Paolo Urbani; Alberto Minassi; Giovanni Appendino; Carmela Saturnino; Billy Martin; Raj Razdan; et al.
Development of the first potent and specific inhibitors of endocannabinoid biosynthesis.
Biochimica et biophysica acta 2006;1761(2):205-12.
2006: Anna Maria Malfitano; Giuseppe Matarese; Simona Pisanti; Claudia Grimaldi; Chiara Laezza; Tiziana Bisogno; Vincenzo Di Marzo; Robert I Lechler; Maurizio Bifulco
Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis.
Journal of neuroimmunology 2006;171(1-2):110-9.
2006: Giovanni Appendino; Maria Grazia Cascio; Sara Bacchiega; Aniello Schiano Moriello; Alberto Minassi; Adèle Thomas; Ruth Ross; Roger Pertwee; Luciano De Petrocellis; Vincenzo Di Marzo
First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands.
FEBS letters 2006;580(2):568-74.
2006: I Matias; V Di Marzo
Endocannabinoid synthesis and degradation, and their regulation in the framework of energy balance.
Journal of endocrinological investigation 2006;29(3 Suppl):15-26.
2006: L Cristino; L de Petrocellis; G Pryce; D Baker; V Guglielmotti; V Di Marzo
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain.
Neuroscience 2006;139(4):1405-15.
2006: Vincenzo Di Marzo; Luciano De Petrocellis
Plant, synthetic, and endogenous cannabinoids in medicine.
Annual review of medicine 2006;57():553-74.
2006: Alessia Ligresti; Maria Grazia Cascio; Gareth Pryce; Sanjitha Kulasegram; Irina Beletskaya; Luciano De Petrocellis; Bijali Saha; Anu Mahadevan; Cristina Visintin; Jenny L Wiley; et al.
New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis.
British journal of pharmacology 2006;147(1):83-91.
2006: Paolo Urbani; Paolo Cavallo; Maria Grazia Cascio; Mariafrancesca Buonerba; Giovanni De Martino; Vincenzo Di Marzo; Carmela Saturnino
New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies.
Bioorganic & medicinal chemistry letters 2006;16(1):138-41.
2005: Alessia Ligresti; Maria Grazia Cascio; Vincenzo Di Marzo
Endocannabinoid metabolic pathways and enzymes.
Current drug targets. CNS and neurological disorders 2005;4(6):615-23.
2005: Antonella Brizzi; Vittorio Brizzi; Maria Grazia Cascio; Tiziana Bisogno; Rossella Sirianni; Vincenzo Di Marzo
Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors.
Journal of medicinal chemistry 2005;48(23):7343-50.
2005: Ana Cabranes; Katerina Venderova; Eva de Lago; Filomena Fezza; Antonio Sánchez; Leyre Mestre; Marta Valenti; Antonio García-Merino; José Antonio Ramos; Vincenzo Di Marzo; et al.
Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis.
Neurobiology of disease 2005;20(2):207-17.
2005: M Valenti; E Cottone; R Martinez; N De Pedro; M Rubio; M P Viveros; M F Franzoni; M J Delgado; V Di Marzo
The endocannabinoid system in the brain of Carassius auratus and its possible role in the control of food intake.
Journal of neurochemistry 2005;95(3):662-72.
2005: Marja D Van Sickle; Marnie Duncan; Philip J Kingsley; Abdeslam Mouihate; Paolo Urbani; Ken Mackie; Nephi Stella; Alexandros Makriyannis; Daniele Piomelli; Joseph S Davison; et al.
Identification and functional characterization of brainstem cannabinoid CB2 receptors.
Science (New York, N.Y.) 2005;310(5746):329-32.
2005: Rocío Sancho; Laureano de la Vega; Antonio Macho; Giovanni Appendino; Vincenzo Di Marzo; Eduardo Muñoz
Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3990-9.
2005: Mario van der Stelt; Marcello Trevisani; Vittorio Vellani; Luciano De Petrocellis; Aniello Schiano Moriello; Barbara Campi; Peter McNaughton; Piero Geppetti; Vincenzo Di Marzo
Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels.
The EMBO journal 2005;24(17):3026-37.
2005: Raffaele Capasso; Isabel Matias; Beat Lutz; Francesca Borrelli; Francesco Capasso; Giovanni Marsicano; Nicola Mascolo; Stefania Petrosino; Krisztina Monory; Marta Valenti; et al.
Fatty acid amide hydrolase controls mouse intestinal motility in vivo.
Gastroenterology 2005;129(3):941-51.
2005: Mario van der Stelt; Vincenzo Di Marzo
Anandamide as an intracellular messenger regulating ion channel activity.
Prostaglandins & other lipid mediators 2005;77(1-4):111-22.
2005: Nissar A Darmani; Bryan A McClanahan; Chung Trinh; Stefania Petrosino; Marta Valenti; Vincenzo Di Marzo
Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew.
Neuropharmacology 2005;49(4):502-13.
2005: Luciano De Petrocellis; Vincenzo Di Marzo
Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels.
Life sciences 2005;77(14):1651-66.
2005: Eva de Lago; Stefania Petrosino; Marta Valenti; Enrico Morera; Silvia Ortega-Gutierrez; Javier Fernandez-Ruiz; Vincenzo Di Marzo
Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels.
Biochemical pharmacology 2005;70(3):446-52.
2005: Silvia Ortega-Gutiérrez; Eduardo Molina-Holgado; Angel Arévalo-Martín; Fernando Correa; Alma Viso; María L López-Rodríguez; Vincenzo Di Marzo; Carmen Guaza
Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(10):1338-40.
2005: Eva de Lago; Paolo Urbani; José Antonio Ramos; Vincenzo Di Marzo; Javier Fernández-Ruiz
Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease.
Brain research 2005;1050(1-2):210-6.
2005: Giovanni Appendino; Nives Daddario; Alberto Minassi; Aniello Schiano Moriello; Luciano De Petrocellis; Vincenzo Di Marzo
The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination.
Journal of medicinal chemistry 2005;48(14):4663-9.
2005: Mario van der Stelt; Susan H Fox; Michael Hill; Alan R Crossman; Stefania Petrosino; Vincenzo Di Marzo; Jonathan M Brotchie
A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1140-2.
2005: Tiziana Bisogno; Alessia Ligresti; Vincenzo Di Marzo
The endocannabinoid signalling system: biochemical aspects.
Pharmacology, biochemistry, and behavior 2005;81(2):224-38.
2005: Isabel Matias; John M McPartland; Vincenzo Di Marzo
Occurrence and possible biological role of the endocannabinoid system in the sea squirt Ciona intestinalis.
Journal of neurochemistry 2005;93(5):1141-56.
2005: Nissar A Darmani; Angelo A Izzo; Brian Degenhardt; Marta Valenti; Giuseppe Scaglione; Raffaele Capasso; Italo Sorrentini; Vincenzo Di Marzo
Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: review of the available pre-clinical data, and first human studies.
Neuropharmacology 2005;48(8):1154-63.
2005: Palmiero Monteleone; Isabelle Matias; Vassilis Martiadis; Luciano De Petrocellis; Mario Maj; Vincenzo Di Marzo
Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(6):1216-21.
2005: June Chen; Isabel Matias; Tim Dinh; Ta Lu; Sonia Venezia; Amelia Nieves; David F Woodward; Vincenzo Di Marzo
Finding of endocannabinoids in human eye tissues: implications for glaucoma.
Biochemical and biophysical research communications 2005;330(4):1062-7.
2005: Vincenzo Di Marzo; Isabel Matias
Endocannabinoid control of food intake and energy balance.
Nature neuroscience 2005;8(5):585-9.
2005: Leyre Mestre; Fernando Correa; Angel Arévalo-Martín; Eduardo Molina-Holgado; Marta Valenti; Giorgio Ortar; Vincenzo Di Marzo; Carmen Guaza
Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis.
Journal of neurochemistry 2005;92(6):1327-39.
2005: Giovanni Appendino; Luciano De Petrocellis; Marcello Trevisani; Alberto Minassi; Nives Daddario; Aniello Schiano Moriello; David Gazzieri; Alessia Ligresti; Barbara Campi; Gabriele Fontana; et al.
Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential.
The Journal of pharmacology and experimental therapeutics 2005;312(2):561-70.
2005: V Di Marzo; L De Petrocellis; T Bisogno
The biosynthesis, fate and pharmacological properties of endocannabinoids.
Handbook of experimental pharmacology 2005;(168):147-85.
2005: Mario van der Stelt; Vincenzo Di Marzo
Cannabinoid receptors and their role in neuroprotection.
Neuromolecular medicine 2005;7(1-2):37-50.
2004: Sandra Holt; David Rocksén; Anders Bucht; Gitte Petersen; Harald S Hansen; Marta Valenti; Vincenzo Di Marzo; Christopher J Fowler
Lipopolysaccharide-induced pulmonary inflammation is not accompanied by a release of anandamide into the lavage fluid or a down-regulation of the activity of fatty acid amide hydrolase.
Life sciences 2004;76(4):461-72.
2004: Miriam Melis; Simona Perra; Anna Lisa Muntoni; Giuliano Pillolla; Beat Lutz; Giovanni Marsicano; Vincenzo Di Marzo; Gian Luigi Gessa; Marco Pistis
Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(47):10707-15.
2004: Ken Soderstrom; Qiyu Tian; Marta Valenti; Vincenzo Di Marzo
Endocannabinoids link feeding state and auditory perception-related gene expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(44):10013-21.
2004: Daniela Viganò; Marta Valenti; Maria Grazia Cascio; Vincenzo Di Marzo; Daniela Parolaro; Tiziana Rubino
Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine.
The European journal of neuroscience 2004;20(7):1849-57.
2004: Sara González; Marta Valenti; Rosario de Miguel; Filomena Fezza; Javier Fernández-Ruiz; Vincenzo Di Marzo; José A Ramos
Changes in endocannabinoid contents in reward-related brain regions of alcohol-exposed rats, and their possible relevance to alcohol relapse.
British journal of pharmacology 2004;143(4):455-64.
2004: Vincenzo Di Marzo; Alessia Ligresti; Enrico Morera; Marianna Nalli; Giorgio Ortar
The anandamide membrane transporter. Structure-activity relationships of anandamide and oleoylethanolamine analogs with phenyl rings in the polar head group region.
Bioorganic & medicinal chemistry 2004;12(19):5161-9.
2004: Maurizio Bifulco; Chiara Laezza; Marta Valenti; Alessia Ligresti; Giuseppe Portella; Vincenzo DI Marzo
A new strategy to block tumor growth by inhibiting endocannabinoid inactivation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(13):1606-8.
2004: Vincenzo Di Marzo; Maurizio Bifulco; Luciano De Petrocellis
The endocannabinoid system and its therapeutic exploitation.
Nature reviews. Drug discovery 2004;3(9):771-84.
2004: Luciano De Petrocellis; Constance J Chu; Aniello Schiano Moriello; Juliane C Kellner; J Michael Walker; Vincenzo Di Marzo
Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels.
British journal of pharmacology 2004;143(2):251-6.
2004: Alessia Ligresti; Enrico Morera; Mario Van Der Stelt; Krisztina Monory; Beat Lutz; Giorgio Ortar; Vincenzo Di Marzo
Further evidence for the existence of a specific process for the membrane transport of anandamide.
The Biochemical journal 2004;380(Pt 1):265-72.
2004: Christopher J Fowler; Gunnar Tiger; Alessia Ligresti; María L López-Rodríguez; Vincenzo Di Marzo
Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis--a difficult issue to handle.
European journal of pharmacology 2004;492(1):1-11.
2004: Sara González; Javier Fernández-Ruiz; Vincenzo Di Marzo; Mariluz Hernández; Cristina Arévalo; Cristina Nicanor; Maria Grazia Cascio; Emilio Ambrosio; José A Ramos
Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence.
Drug and alcohol dependence 2004;74(2):159-70.
2004: Mario Van Der Stelt; Vincenzo Di Marzo
Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels.
European journal of biochemistry / FEBS 2004;271(10):1827-34.
2004: I Matias; J Chen; L De Petrocellis; T Bisogno; A Ligresti; F Fezza; A H-P Krauss; L Shi; C E Protzman; C Li; et al.
Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism.
The Journal of pharmacology and experimental therapeutics 2004;309(2):745-57.
2004: M Valenti; D Viganò; M G Casico; T Rubino; L Steardo; D Parolaro; V Di Marzo
Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain.
Cellular and molecular life sciences : CMLS 2004;61(7-8):945-50.
2004: Luciano De Petrocellis; Maria Grazia Cascio; Vincenzo Di Marzo
The endocannabinoid system: a general view and latest additions.
British journal of pharmacology 2004;141(5):765-74.
2004: Maria Grazia Cascio; Alberto Minassi; Alessia Ligresti; Giovanni Appendino; Sumner Burstein; Vincenzo Di Marzo
A structure-activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase.
Biochemical and biophysical research communications 2004;314(1):192-6.
2004: Eva de Lago; Alessia Ligresti; Giorgio Ortar; Enrico Morera; Ana Cabranes; Gareth Pryce; Maurizio Bifulco; David Baker; Javier Fernandez-Ruiz; Vincenzo Di Marzo
In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake.
European journal of pharmacology 2004;484(2-3):249-57.
2003: Tiziana Bisogno; Fiona Howell; Gareth Williams; Alberto Minassi; Maria Grazia Cascio; Alessia Ligresti; Isabel Matias; Aniello Schiano-Moriello; Praveen Paul; Emma-Jane Williams; et al.
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain.
The Journal of cell biology 2003;163(3):463-8.
2003: Mario van der Stelt; Vincenzo Di Marzo
The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders.
European journal of pharmacology 2003;480(1-3):133-50.
2003: Rocio Sancho; Laureano de la Vega; Giovanni Appendino; Vincenzo Di Marzo; Antonio Macho; Eduardo Munoz
The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway.
British journal of pharmacology 2003;140(6):1035-44.
2003: Giovanni Marsicano; Sharon Goodenough; Krisztina Monory; Heike Hermann; Matthias Eder; Astrid Cannich; Shahnaz C Azad; Maria Grazia Cascio; Silvia Ortega Gutiérrez; Mario van der Stelt; et al.
CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
Science (New York, N.Y.) 2003;302(5642):84-8.
2003: Bingnan Han; Kerry L McPhail; Alessia Ligresti; Vincenzo Di Marzo; William H Gerwick
Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena.
Journal of natural products 2003;66(10):1364-8.
2003: Giuseppe Portella; Chiara Laezza; Paolo Laccetti; Luciano De Petrocellis; Vincenzo Di Marzo; Maurizio Bifulco
Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1771-3.
2003: Angelo A Izzo; Francesco Capasso; Anna Costagliola; Tiziana Bisogno; Giovanni Marsicano; Alessia Ligresti; Isabel Matias; Raffaele Capasso; Luisa Pinto; Francesca Borrelli; et al.
An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice.
Gastroenterology 2003;125(3):765-74.
2003: Alessia Ligresti; Tiziana Bisogno; Isabel Matias; Luciano De Petrocellis; Maria Grazia Cascio; Vittorio Cosenza; Giuseppe D'argenio; Giuseppe Scaglione; Maurizio Bifulco; Italo Sorrentini; et al.
Possible endocannabinoid control of colorectal cancer growth.
Gastroenterology 2003;125(3):677-87.
2003: Nicola De Marchi; Luciano De Petrocellis; Pierangelo Orlando; Fabiana Daniele; Filomena Fezza; Vincenzo Di Marzo
Endocannabinoid signalling in the blood of patients with schizophrenia.
Lipids in health and disease 2003;2():5.
2003: Selena Harrison; Luciano De Petrocellis; Marcello Trevisani; Francesca Benvenuti; Maurizio Bifulco; Pierangelo Geppetti; Vincenzo Di Marzo
Capsaicin-like effects of N-arachidonoyl-dopamine in the isolated guinea pig bronchi and urinary bladder.
European journal of pharmacology 2003;475(1-3):107-14.
2003: Giovanni Appendino; Selena Harrison; Luciano De Petrocellis; Nives Daddario; Federica Bianchi; Aniello Schiano Moriello; Marcello Trevisani; Francesca Benvenuti; Pierangelo Geppetti; Vincenzo Di Marzo
Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists.
British journal of pharmacology 2003;139(8):1417-24.
2003: Filomena Fezza; Jack W Dillwith; Tiziana Bisogno; James S Tucker; Vincenzo Di Marzo; John R Sauer
Endocannabinoids and related fatty acid amides, and their regulation, in the salivary glands of the lone star tick.
Biochimica et biophysica acta 2003;1633(1):61-7.
2003: Vincenzo Di Marzo
Manipulation of the endocannabinoid system by a general anaesthetic.
British journal of pharmacology 2003;139(5):885-6.
2003: Daniela Viganò; Maria Grazia Cascio; Tiziana Rubino; Filomena Fezza; Angelo Vaccani; Vincenzo Di Marzo; Daniela Parolaro
Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(6):1160-7.
2003: W B Veldhuis; M van der Stelt; M W Wadman; G van Zadelhoff; M Maccarrone; F Fezza; G A Veldink; J F G Vliegenthart; P R Bär; K Nicolay; et al.
Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(10):4127-33.
2003: Giorgio Ortar; Alessia Ligresti; Luciano De Petrocellis; Enrico Morera; Vincenzo Di Marzo
Novel selective and metabolically stable inhibitors of anandamide cellular uptake.
Biochemical pharmacology 2003;65(9):1473-81.
2003: Maurizio Bifulco; Vincenzo Di Marzo
[The endocannabinoid system as a target for the development of new drugs for cancer therapy].
Recenti progressi in medicina 2003;94(5):194-8.
2003: Constance J Chu; Susan M Huang; Luciano De Petrocellis; Tiziana Bisogno; Scott A Ewing; Jeffrey D Miller; Robert E Zipkin; Nives Daddario; Giovanni Appendino; Vincenzo Di Marzo; et al.
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
The Journal of biological chemistry 2003;278(16):13633-9.
2003: Silvia Marinelli; Vincenzo Di Marzo; Nicola Berretta; Isabel Matias; Mauro Maccarrone; Giorgio Bernardi; Nicola B Mercuri
Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(8):3136-44.
2003: H Hermann; L De Petrocellis; T Bisogno; A Schiano Moriello; B Lutz; V Di Marzo
Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response.
Cellular and molecular life sciences : CMLS 2003;60(3):607-16.
2003: Isabel Lastres-Becker; Rosario de Miguel; Luciano De Petrocellis; Alexandros Makriyannis; Vincenzo Di Marzo; Javier Fernández-Ruiz
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.
Journal of neurochemistry 2003;84(5):1097-109.
2003: I Matias; M Léonhardt; J Lesage; L De Petrocellis; J P Dupouy; D Vieau; V Di Marzo
Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels.
Cellular and molecular life sciences : CMLS 2003;60(2):382-9.
2003: Rocío Sancho; Marco A Calzado; Vincenzo Di Marzo; Giovanni Appendino; Eduardo Muñoz
Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway.
Molecular pharmacology 2003;63(2):429-38.
2003: Giovanni Appendino; Alessia Ligresti; Alberto Minassi; Nives Daddario; Tiziana Bisogno; Vincenzo Di Marzo
Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors.
Bioorganic & medicinal chemistry letters 2003;13(1):43-6.
2003: Luciano De Petrocellis; Tiziana Bisogno; Vincenzo Di Marzo
Neuromodulatory actions neuromodulatory actions of endocannabinoids in pain and sedation.
Advances in experimental medicine and biology 2003;523():215-25.
2002: Giuseppe Esposito; Alessia Ligresti; Angelo A Izzo; Tiziana Bisogno; Menotti Ruvo; Massimo Di Rosa; Vincenzo Di Marzo; Teresa Iuvone
The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity. Mechanism and regulation.
The Journal of biological chemistry 2002;277(52):50348-54.
2002: Nicola Mascolo; Angelo A Izzo; Alessia Ligresti; Anna Costagliola; Luisa Pinto; Maria G Cascio; Pasquale Maffia; Aldo Cecio; Francesco Capasso; Vincenzo Di Marzo
The endocannabinoid system and the molecular basis of paralytic ileus in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1973-5.
2002: Sara González; Maria Grazia Cascio; Javier Fernández-Ruiz; Filomena Fezza; Vincenzo Di Marzo; José A Ramos
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine.
Brain research 2002;954(1):73-81.
2002: Mario van der Stelt; Wouter B Veldhuis; Mauro Maccarrone; Peter R Bär; Klaas Nicolay; Gerrit A Veldink; Vincenzo Di Marzo; Johannes F G Vliegenthart
Acute neuronal injury, excitotoxicity, and the endocannabinoid system.
Molecular neurobiology 2002;26(2-3):317-46.
2002: Giovanni Appendino; Alberto Minassi; Aniello Schiano Morello; Luciano De Petrocellis; Vincenzo Di Marzo
N-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor.
Journal of medicinal chemistry 2002;45(17):3739-45.
2002: Luciano De Petrocellis; Tiziana Bisogno; Alessia Ligresti; Maurizio Bifulco; Dominique Melck; Vincenzo Di Marzo
Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems.
Fundamental & clinical pharmacology 2002;16(4):297-302.
2002: Isabel Matias; Pierre Pochard; Pierangelo Orlando; Michel Salzet; Joel Pestel; Vincenzo Di Marzo
Presence and regulation of the endocannabinoid system in human dendritic cells.
European journal of biochemistry / FEBS 2002;269(15):3771-8.
2002: Giovanni Marsicano; Carsten T Wotjak; Shahnaz C Azad; Tiziana Bisogno; Gerhard Rammes; Maria Grazia Cascio; Heike Hermann; Jianrong Tang; Clementine Hofmann; Walter Zieglgänsberger; et al.
The endogenous cannabinoid system controls extinction of aversive memories.
Nature 2002;418(6897):530-4.
2002: Vincenzo Di Marzo; Peter M Blumberg; Arpad Szallasi
Endovanilloid signaling in pain.
Current opinion in neurobiology 2002;12(4):372-9.
2002: Luisa Pinto; Angelo A Izzo; Maria Grazia Cascio; Tiziana Bisogno; Karen Hospodar-Scott; David R Brown; Nicola Mascolo; Vincenzo Di Marzo; Francesco Capasso
Endocannabinoids as physiological regulators of colonic propulsion in mice.
Gastroenterology 2002;123(1):227-34.
2002: Susan M Huang; Tiziana Bisogno; Marcello Trevisani; Abdulmonem Al-Hayani; Luciano De Petrocellis; Filomena Fezza; Michele Tognetto; Timothy J Petros; Jocelyn F Krey; Constance J Chu; et al.
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8400-5.
2002: Tim C Kirkham; Claire M Williams; Filomena Fezza; Vincenzo Di Marzo
Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol.
British journal of pharmacology 2002;136(4):550-7.
2002: Maurizio Bifulco; Vincenzo Di Marzo
Targeting the endocannabinoid system in cancer therapy: a call for further research.
Nature medicine 2002;8(6):547-50.
2002: Jason W Brooks; Gareth Pryce; Tiziana Bisogno; Siân I Jaggar; Deborah J R Hankey; Peter Brown; Daniel Bridges; Catherine Ledent; Maurizio Bifulco; Andrew S C Rice; et al.
Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors.
European journal of pharmacology 2002;439(1-3):83-92.
2002: Vincenzo Di Marzo; Graeme Griffin; Luciano De Petrocellis; Ines Brandi; Tiziana Bisogno; William Williams; Mark C Grier; Sanjitha Kulasegram; Anu Mahadevan; Raj K Razdan; et al.
A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid.
The Journal of pharmacology and experimental therapeutics 2002;300(3):984-91.
2002: Filomena Fezza; Tiziana Bisogno; Alberto Minassi; Giovanni Appendino; Raphael Mechoulam; Vincenzo Di Marzo
Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues.
FEBS letters 2002;513(2-3):294-8.
2002: Tibor Wenger; Ida Gerendai; Filomena Fezza; Sara González; Tiziana Bisogno; Javier Fernandez-Ruiz; Vincenzo Di Marzo
The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats.
Life sciences 2002;70(12):1407-14.
2002: Vincenzo Di Marzo; L De Petrocellis; F Fezza; A Ligresti; T Bisogno
Anandamide receptors.
Prostaglandins, leukotrienes, and essential fatty acids 2002;66(2-3):377-91.
2002: Vincenzo Di Marzo
Endocannabinoids in the new millennium.
Prostaglandins, leukotrienes, and essential fatty acids 2002;66(2-3):91-2.
2002: Mauro Maccarrone; Tiziana Bisogno; Herbert Valensise; Natalia Lazzarin; Filomena Fezza; Claudio Manna; Vincenzo Di Marzo; Alessandro Finazzi-Agrò
Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer.
Molecular human reproduction 2002;8(2):188-95.
2002: Dominique Melck; Tiziana Bisogno; Luciano De Petrocellis; Pierre Beaulieu; Andrew S C Rice; Vincenzo Di Marzo
Cannabimimetic eicosanoids in cancer and inflammation: an update.
Advances in experimental medicine and biology 2002;507():381-6.
2002: Tiziana Bisogno; Luciano De Petrocellis; Vincenzo Di Marzo
Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications.
Current pharmaceutical design 2002;8(7):533-47.
2001: M Bifulco; C Laezza; G Portella; M Vitale; P Orlando; L De Petrocellis; V Di Marzo
Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2745-7.
2001: S M Huang; T Bisogno; T J Petros; S Y Chang; P A Zavitsanos; R E Zipkin; R Sivakumar; A Coop; D Y Maeda; L De Petrocellis; et al.
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.
The Journal of biological chemistry 2001;276(46):42639-44.
2001: M van der Stelt; W B Veldhuis; G W van Haaften; F Fezza; T Bisogno; P R Bar; G A Veldink; J F Vliegenthart; V Di Marzo; K Nicolay
Exogenous anandamide protects rat brain against acute neuronal injury in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(22):8765-71.
2001: L De Petrocellis; J B Davis; V Di Marzo
Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors.
FEBS letters 2001;506(3):253-6.
2001: T Bisogno; L Hanus; L De Petrocellis; S Tchilibon; D E Ponde; I Brandi; A S Moriello; J B Davis; R Mechoulam; V Di Marzo
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
British journal of pharmacology 2001;134(4):845-52.
2001: A A Izzo; F Fezza; R Capasso; T Bisogno; L Pinto; T Iuvone; G Esposito; N Mascolo; V Di Marzo; F Capasso
Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation.
British journal of pharmacology 2001;134(3):563-70.
2001: M Maccarrone; L De Petrocellis; M Bari; F Fezza; S Salvati; V Di Marzo; A Finazzi-Agrò
Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes.
Archives of biochemistry and biophysics 2001;393(2):321-8.
2001: V Di Marzo; D Melck; P Orlando; T Bisogno; O Zagoory; M Bifulco; Z Vogel; L De Petrocellis
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells.
The Biochemical journal 2001;358(Pt 1):249-55.
2001: J McPartland; V Di Marzo; L De Petrocellis; A Mercer; M Glass
Cannabinoid receptors are absent in insects.
The Journal of comparative neurology 2001;436(4):423-9.
2001: I Lastres-Becker; F Fezza; M Cebeira; T Bisogno; J A Ramos; A Milone; J Fernández-Ruiz; V Di Marzo
Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease.
Neuroreport 2001;12(10):2125-9.
2001: V Di Marzo; T Bisogno; L De Petrocellis
Anandamide: some like it hot.
Trends in pharmacological sciences 2001;22(7):346-9.
2001: C S Breivogel; G Griffin; V Di Marzo; B R Martin
Evidence for a new G protein-coupled cannabinoid receptor in mouse brain.
Molecular pharmacology 2001;60(1):155-63.
2001: L De Petrocellis; S Harrison; T Bisogno; M Tognetto; I Brandi; G D Smith; C Creminon; J B Davis; P Geppetti; V Di Marzo
The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase.
Journal of neurochemistry 2001;77(6):1660-3.
2001: U Pagotto; G Marsicano; F Fezza; M Theodoropoulou; Y Grübler; J Stalla; T Arzberger; A Milone; M Losa; V Di Marzo; et al.
Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level.
The Journal of clinical endocrinology and metabolism 2001;86(6):2687-96.
2001: V Di Marzo; I Lastres-Becker; T Bisogno; L De Petrocellis; A Milone; J B Davis; J J Fernandez-Ruiz
Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues.
European journal of pharmacology 2001;420(2-3):123-31.
2001: A Berger; G Crozier; T Bisogno; P Cavaliere; S Innis; V Di Marzo
Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6402-6.
2001: E Fride; Y Ginzburg; A Breuer; T Bisogno; V Di Marzo; R Mechoulam
Critical role of the endogenous cannabinoid system in mouse pup suckling and growth.
European journal of pharmacology 2001;419(2-3):207-14.
2001: L De Petrocellis; T Bisogno; M Maccarrone; J B Davis; A Finazzi-Agro; V Di Marzo
The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism.
The Journal of biological chemistry 2001;276(16):12856-63.
2001: V Di Marzo; S K Goparaju; L Wang; J Liu; S Bátkai; Z Járai; F Fezza; G I Miura; R D Palmiter; T Sugiura; et al.
Leptin-regulated endocannabinoids are involved in maintaining food intake.
Nature 2001;410(6830):822-5.
2001: T Bisogno; M MacCarrone; L De Petrocellis; A Jarrahian; A Finazzi-Agrò; C Hillard; V Di Marzo
The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors.
European journal of biochemistry / FEBS 2001;268(7):1982-9.
2001: V Bezuglov; M Bobrov; N Gretskaya; A Gonchar; G Zinchenko; D Melck; T Bisogno; V Di Marzo; D Kuklev; J C Rossi; et al.
Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine.
Bioorganic & medicinal chemistry letters 2001;11(4):447-9.
2001: V Di Marzo; T Bisogno; L De Petrocellis; I Brandi; R G Jefferson; R L Winckler; J B Davis; O Dasse; A Mahadevan; R K Razdan; et al.
Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands.
Biochemical and biophysical research communications 2001;281(2):444-51.
2001: D Baker; G Pryce; J L Croxford; P Brown; R G Pertwee; A Makriyannis; A Khanolkar; L Layward; F Fezza; T Bisogno; et al.
Endocannabinoids control spasticity in a multiple sclerosis model.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):300-2.
2000: V Di Marzo; C S Breivogel; Q Tao; D T Bridgen; R K Razdan; A M Zimmer; A Zimmer; B R Martin
Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain.
Journal of neurochemistry 2000;75(6):2434-44.
2000: T Bisogno; D Melck; Bobrov MYu; N M Gretskaya; V V Bezuglov; L De Petrocellis; V Di Marzo
N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo.
The Biochemical journal 2000;351 Pt 3():817-24.
2000: V Di Marzo; C Breivogel; T Bisogno; D Melck; G Patrick; Q Tao; A Szallasi; R K Razdan; B R Martin
Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide.
European journal of pharmacology 2000;406(3):363-74.
2000: L De Petrocellis; T Bisogno; J B Davis; R G Pertwee; V Di Marzo
Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity.
FEBS letters 2000;483(1):52-6.
2000: B R Martin; I Beletskaya; G Patrick; R Jefferson; R Winckler; D G Deutsch; V Di Marzo; O Dasse; A Mahadevan; R K Razdan
Cannabinoid properties of methylfluorophosphonate analogs.
The Journal of pharmacology and experimental therapeutics 2000;294(3):1209-18.
2000: V Di Marzo; M Bifulco; L De Petrocellis
Endocannabinoids and multiple sclerosis: a blessing from the 'inner bliss'?
Trends in pharmacological sciences 2000;21(6):195-7.
2000: P Beaulieu1; T Bisogno1; S Punwar; W P Farquhar-Smith; G Ambrosino; V Di Marzo; A S Rice
Role of the endogenous cannabinoid system in the formalin test of persistent pain in the rat.
European journal of pharmacology 2000;396(2-3):85-92.
2000: M Maccarrone; M Bari; T Lorenzon; T Bisogno; V Di Marzo; A Finazzi-Agrò
Anandamide uptake by human endothelial cells and its regulation by nitric oxide.
The Journal of biological chemistry 2000;275(18):13484-92.
2000: S González; T Bisogno; T Wenger; J Manzanares; A Milone; F Berrendero; V Di Marzo; J A Ramos; J J Fernández-Ruiz
Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland.
Biochemical and biophysical research communications 2000;270(1):260-6.
2000: V Di Marzo; D Melck; L De Petrocellis; T Bisogno
Cannabimimetic fatty acid derivatives in cancer and inflammation.
Prostaglandins & other lipid mediators 2000;61(1-2):43-61.
2000: V Di Marzo; F Berrendero; T Bisogno; S González; P Cavaliere; J Romero; M Cebeira; J A Ramos; J J Fernández-Ruiz
Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta9-tetrahydrocannabinol-tolerant rats.
Journal of neurochemistry 2000;74(4):1627-35.
2000: D Melck; L De Petrocellis; P Orlando; T Bisogno; C Laezza; M Bifulco; V Di Marzo
Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation.
Endocrinology 2000;141(1):118-26.
1999: D Melck; D Rueda; I Galve-Roperh; L De Petrocellis; M Guzmán; V Di Marzo
Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells.
FEBS letters 1999;463(3):235-40.
1999: T Bisogno; I Delton-Vandenbroucke; A Milone; M Lagarde; V Di Marzo
Biosynthesis and inactivation of N-arachidonoylethanolamine (anandamide) and N-docosahexaenoylethanolamine in bovine retina.
Archives of biochemistry and biophysics 1999;370(2):300-7.
1999: F Berrendero; N Sepe; J A Ramos; V Di Marzo; J J Fernández-Ruiz
Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period.
Synapse (New York, N.Y.) 1999;33(3):181-91.
1999: D Melck; T Bisogno; L De Petrocellis; H Chuang; D Julius; M Bifulco; V Di Marzo
Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors.
Biochemical and biophysical research communications 1999;262(1):275-84.
1999: V Di Marzo; T Bisogno; L De Petrocellis; D Melck; B R Martin
Cannabimimetic fatty acid derivatives: the anandamide family and other endocannabinoids.
Current medicinal chemistry 1999;6(8):721-44.
1999: S González; J Manzanares; F Berrendero; T Wenger; J Corchero; T Bisogno; J Romero; J A Fuentes; V Di Marzo; J A Ramos; et al.
Identification of endocannabinoids and cannabinoid CB(1) receptor mRNA in the pituitary gland.
Neuroendocrinology 1999;70(2):137-45.
1999: V Di Marzo; T Bisogno; L De Petrocellis; D Melck; P Orlando; J A Wagner; G Kunos
Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages.
European journal of biochemistry / FEBS 1999;264(1):258-67.
1999: P M Zygmunt; J Petersson; D A Andersson; H Chuang; M Sørgård; V Di Marzo; D Julius; E D Högestätt
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide.
Nature 1999;400(6743):452-7.
1999: T Bisogno; D Melck; L De Petrocellis; V Di Marzo
Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin.
Journal of neurochemistry 1999;72(5):2113-9.
1999: T Bisogno; F Berrendero; G Ambrosino; M Cebeira; J A Ramos; J J Fernandez-Ruiz; V Di Marzo
Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological function.
Biochemical and biophysical research communications 1999;256(2):377-80.
1999: N Ueda; K Katayama; Y Kurahashi; M Suzuki; H Suzuki; S Yamamoto; I Katoh; V Di Marzo; L De Petrocellis
Enzymological and molecular biological studies on anandamide amidohydrolase.
Advances in experimental medicine and biology 1999;469():513-8.
1999: V Di Marzo
Biosynthesis and inactivation of endocannabinoids: relevance to their proposed role as neuromodulators.
Life sciences 1999;65(6-7):645-55.
1999: V Di Marzo; L De Petrocellis; T Bisogno; D Melck
Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments.
Lipids 1999;34 Suppl():S319-25.
1999: L De Petrocellis; D Melck; T Bisogno; A Milone; V Di Marzo
Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: possible role in the feeding response.
Neuroscience 1999;92(1):377-87.
1998: V Di Marzo; N Sepe; L De Petrocellis; A Berger; G Crozier; E Fride; R Mechoulam
Trick or treat from food endocannabinoids?
Nature 1998;396(6712):636-7.
1998: V Di Marzo; D G Deutsch
Biochemistry of the endogenous ligands of cannabinoid receptors.
Neurobiology of disease 1998;5(6 Pt B):386-404.
1998: V Di Marzo; D Melck; T Bisogno; L De Petrocellis
Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action.
Trends in neurosciences 1998;21(12):521-8.
1998: R Mechoulam; E Fride; V Di Marzo
Endocannabinoids.
European journal of pharmacology 1998;359(1):1-18.
1998: V Di Marzo; T Bisogno; D Melck; R Ross; H Brockie; L Stevenson; R Pertwee; L De Petrocellis
Interactions between synthetic vanilloids and the endogenous cannabinoid system.
FEBS letters 1998;436(3):449-54.
1998: T Bisogno; D Melck; L De Petrocellis; Bobrov MYu; N M Gretskaya; V V Bezuglov; N Sitachitta; W H Gerwick; V Di Marzo
Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.
Biochemical and biophysical research communications 1998;248(3):515-22.
1998: S Ben-Shabat; E Fride; T Sheskin; T Tamiri; M H Rhee; Z Vogel; T Bisogno; L De Petrocellis; V Di Marzo; R Mechoulam
An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity.
European journal of pharmacology 1998;353(1):23-31.
1998: T Bisogno; K Katayama; D Melck; N Ueda; L De Petrocellis; S Yamamoto; V Di Marzo
Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells--implications for cell proliferation and differentiation.
European journal of biochemistry / FEBS 1998;254(3):634-42.
1998: V Di Marzo
'Endocannabinoids' and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance.
Biochimica et biophysica acta 1998;1392(2-3):153-75.
1998: V Di Marzo; T Bisogno; T Sugiura; D Melck; L De Petrocellis
The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamide.
The Biochemical journal 1998;331 ( Pt 1)():15-9.
1998: N Sepe; L De Petrocellis; F Montanaro; G Cimino; V Di Marzo
Bioactive long chain N-acylethanolamines in five species of edible bivalve molluscs. Possible implications for mollusc physiology and sea food industry.
Biochimica et biophysica acta 1998;1389(2):101-11.
1997: T Bisogno; N Sepe; L De Petrocellis; R Mechoulam; V Di Marzo
The sleep inducing factor oleamide is produced by mouse neuroblastoma cells.
Biochemical and biophysical research communications 1997;239(2):473-9.
1997: R Mechoulam; E Fride; L Hanus; T Sheskin; T Bisogno; V Di Marzo; M Bayewitch; Z Vogel
Anandamide may mediate sleep induction.
Nature 1997;389(6646):25-6.
1997: T Bisogno; M Ventriglia; A Milone; M Mosca; G Cimino; V Di Marzo
Occurrence and metabolism of anandamide and related acyl-ethanolamides in ovaries of the sea urchin Paracentrotus lividus.
Biochimica et biophysica acta 1997;1345(3):338-48.
1997: T Bisogno; N Sepe; D Melck; S Maurelli; L De Petrocellis; V Di Marzo
Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells.
The Biochemical journal 1997;322 ( Pt 2)():671-7.
1997: T Bisogno; S Maurelli; D Melck; L De Petrocellis; V Di Marzo
Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes.
The Journal of biological chemistry 1997;272(6):3315-23.
1997: L De Petrocellis; D Melck; N Ueda; S Maurelli; Y Kurahashi; S Yamamoto; G Marino; V Di Marzo
Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase.
Biochemical and biophysical research communications 1997;231(1):82-8.
1997: L De Petrocellis; D Melck; N Ueda; Y Kurahashi; T Bisogno; S Yamamoto; V Di Marzo
Brain and peripheral anandamide amidohydrolase and its inhibition by synthetic arachidonate analogues.
Advances in experimental medicine and biology 1997;433():259-63.
1997: T Bisogno; N Sepe; L De Petrocellis; V Di Marzo
Biosynthesis of 2-arachidonoyl-glycerol, a novel cannabimimetic eicosanoid, in mouse neuroblastoma cells.
Advances in experimental medicine and biology 1997;433():201-4.
1997: V Di Marzo; L De Petrocellis; T Bisogno; S Maurelli
The endogenous cannabimimetic eicosanoid, anandamide, induces arachidonate release in J774 mouse macrophages.
Advances in experimental medicine and biology 1997;407():341-6.
1996: V Di Marzo; L De Petrocellis; T Sugiura; K Waku
Potential biosynthetic connections between the two cannabimimetic eicosanoids, anandamide and 2-arachidonoyl-glycerol, in mouse neuroblastoma cells.
Biochemical and biophysical research communications 1996;227(1):281-8.
1996: L De Petrocellis; P Orlando; M Gavagnin; M Ventriglia; G Cimino; V Di Marzo
Novel diterpenoid diacylglycerols from marine molluscs: potent morphogens and protein kinase C activators.
Experientia 1996;52(9):874-7.
1996: V Di Marzo; L De Petrocellis; N Sepe; A Buono
Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells.
The Biochemical journal 1996;316 ( Pt 3)():977-84.
1995: S Maurelli; T Bisogno; L De Petrocellis; A Di Luccia; G Marino; V Di Marzo
Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma 'anandamide amidohydrolase'.
FEBS letters 1995;377(1):82-6.
1995: A Fontana; V Di Marzo; H Cadas; D Piomelli
Analysis of anandamide, an endogenous cannabinoid substance, and of other natural N-acylethanolamines.
Prostaglandins, leukotrienes, and essential fatty acids 1995;53(4):301-8.
1995: V Di Marzo
Arachidonic acid and eicosanoids as targets and effectors in second messenger interactions.
Prostaglandins, leukotrienes, and essential fatty acids 1995;53(4):239-54.
1995: L De Petrocellis; P Orlando; V Di Marzo
Anandamide, an endogenous cannabinomimetic substance, modulates rat brain protein kinase C in vitro.
Biochemistry and molecular biology international 1995;36(6):1127-33.
1995: V Di Marzo; A Fontana
Anandamide, an endogenous cannabinomimetic eicosanoid: 'killing two birds with one stone'.
Prostaglandins, leukotrienes, and essential fatty acids 1995;53(1):1-11.
1994: V Di Marzo; A Fontana; H Cadas; S Schinelli; G Cimino; J C Schwartz; D Piomelli
Formation and inactivation of endogenous cannabinoid anandamide in central neurons.
Nature 1994;372(6507):686-91.
1994: V Di Marzo; C Gianfrani; L De Petrocellis; A Milone; G Cimino
Polyunsaturated-fatty-acid oxidation in Hydra: regioselectivity, substrate-dependent enantioselectivity and possible biological role.
The Biochemical journal 1994;300 ( Pt 2)():501-7.
1993: V Di Marzo; L De Petrocellis; C Gianfrani; G Cimino
Biosynthesis, structure and biological activity of hydroxyeicosatetraenoic acids in Hydra vulgaris.
The Biochemical journal 1993;295 ( Pt 1)():23-9.
1992: V Di Marzo; D Piomelli
Participation of prostaglandin E2 in dopamine D2 receptor-dependent potentiation of arachidonic acid release.
Journal of neurochemistry 1992;59(1):379-82.
1991: V Di Marzo; G Cimino; A Crispino; C Minardi; G Sodano; A Spinella
A novel multifunctional metabolic pathway in a marine mollusc leads to unprecedented prostaglandin derivatives (prostaglandin 1,15-lactones).
The Biochemical journal 1991;273 ( Pt 3)():593-600.
1991: G Cimino; A Crispino; V Di Marzo; G Sodano; A Spinella; G Villani
A marine mollusc provides the first example of in vivo storage of prostaglandins: prostaglandin-1,15-lactones.
Experientia 1991;47(1):56-60.
1991: V Di Marzo; G Cimino; G Sodano; A Spinella; G Villani
A novel prostaglandin metabolic pathway from a marine mollusc: prostaglandin-1,15-lactones.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():129-32.
1991: L De Petrocellis; V Di Marzo; B Arcà; M Gavagnin; R Minei; G Cimino
The effect of diterpenoidic diacylglycerols on tentacle regeneration in Hydra vulgaris.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1991;100(3):603-7.
1990: G Cimino; A Crispino; V Di Marzo; M Gavagnin; J D Ros
Oxytoxins, bioactive molecules produced by the marine opisthobranch mollusc Oxynoe olivacea from a diet-derived precursor.
Experientia 1990;46(7):767-70.