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Franco Di Padova

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Marije I Koenders; Renoud J Marijnissen; Fons A J van de Loo; Wim B van den Berg; Shahla Abdollahi-Roodsaz; Franco E Di Padova; John Dulos; Leo A B Joosten; Annemieke M H Boots
T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4Ig but is successfully treated by interleukin-17 neutralization.
Frank van de Veerdonk; Bernard Lauwerys; Renoud J Marijnissen; Kim Timmermans; Franco E Di Padova; Marije I Koenders; Ilse Gutierrez-Roelens; Patrick Durez; Mihai G Netea; Jos W M van der Meer; Wim B van den Berg; Leo A B Joosten
The anti-CD20 antibody rituximab reduces the Th17 cell response.
Bernadette Pöllinger; Tobias Junt; Barbara Metzler; Ulrich A Walker; Alan Tyndall; Cyril Allard; Serkan Bay; Roland Keller; Friedrich Raulf; Franco E Di Padova; Terence O'Reilly; Nicole J Horwood; Dhavalkumar D Patel; Amanda Littlewood-Evans
Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans.

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All Publications

2012: Marije I Koenders; Renoud J Marijnissen; Fons A J van de Loo; Wim B van den Berg; Shahla Abdollahi-Roodsaz; Franco E Di Padova; John Dulos; Leo A B Joosten; Annemieke M H Boots
T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4Ig but is successfully treated by interleukin-17 neutralization.
Arthritis and rheumatism 2012;64(6):1762-70.
2011: Frank van de Veerdonk; Bernard Lauwerys; Renoud J Marijnissen; Kim Timmermans; Franco E Di Padova; Marije I Koenders; Ilse Gutierrez-Roelens; Patrick Durez; Mihai G Netea; Jos W M van der Meer; Wim B van den Berg; Leo A B Joosten
The anti-CD20 antibody rituximab reduces the Th17 cell response.
Arthritis and rheumatism 2011;63(6):1507-16.
2011: Bernadette Pöllinger; Tobias Junt; Barbara Metzler; Ulrich A Walker; Alan Tyndall; Cyril Allard; Serkan Bay; Roland Keller; Friedrich Raulf; Franco E Di Padova; Terence O'Reilly; Nicole J Horwood; Dhavalkumar D Patel; Amanda Littlewood-Evans
Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2602-12.
2011: Paméla Gasse; François Huaux; Vincent Lagente; Marc Le Bert; Maria Leite-de-Moraes; Marie-Laure Michel; Valerie QUESNIAUX; Nicolas Riteau; Bernhard RYFFEL; Rachel Vacher; Franco E Di Padova; Gérard Eberl; Alain Fautrel; Lizette Fick; Sabine Charron; Isabelle Couillin
IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis.
PloS one 2011;6(8):e23185.
2010: Wolfgang Hueber; Dhavalkumar D Patel; Thaddeus Dryja; Andrew M Wright; Irina Koroleva; Gerard Bruin; Christian Antoni; Zoe Draelos; Michael H Gold; Patrick Durez; Paul P Tak; Juan J Gomez-Reino; C Stephen Foster; Rosa Y Kim; C Michael Samson; Naomi S Falk; David S Chu; David Callanan; Quan Dong Nguyen; Kristine Rose; Asifa Haider; Franco E Di Padova
Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis.
Science translational medicine 2010;2(52):52ra72.
2008: Marije I Koenders; Isabel Devesa; Renoud J Marijnissen; Shahla Abdollahi-Roodsaz; Mieke Boots; Birgitte Walgreen; Franco E Di Padova; Martin J H Nicklin; Leo A B Joosten; Wim B van den Berg
Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice.
Arthritis and rheumatism 2008;58(11):3461-70.
2006: Marije I Koenders; Erik Lubberts; Fons A J van de Loo; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Monique M A Helsen; Jay K Kolls; Franco E Di Padova; Leo A B Joosten; Wim B van den Berg
Interleukin-17 acts independently of TNF-alpha under arthritic conditions.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6262-9.
2006: Laszlo Revesz; Ernst Blum; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Ulf Neumann; Gerard Rucklin
Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.
Bioorganic & medicinal chemistry letters 2006;16(2):262-6.
2005: Marije I Koenders; Erik Lubberts; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Monique M A Helsen; Franco E Di Padova; Mieke Boots; Hermann Gram; Leo A B Joosten; Wim B van den Berg
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.
The American journal of pathology 2005;167(1):141-9.
2005: Silvia Schnyder-Candrian; Valerie QUESNIAUX; Franco E Di Padova; Isabelle Maillet; Nicolas Noulin; Isabelle Couillin; René Moser; François Erard; B Boris Vargaftig; Bernhard RYFFEL; Bruno Schnyder
Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):262-9.
2005: Qing Jing; Shuang Huang; Sabine Guth; Tyler Zarubin; Andrea Motoyama; Jianming Chen; Franco E Di Padova; Sheng-Cai Lin; Hermann Gram; Jiahuai Han
Involvement of microRNA in AU-rich element-mediated mRNA instability.
Cell 2005;120(5):623-34.
2004: Laszlo Revesz; Ernst Blum; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Gerard Rucklin
SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity.
Bioorganic & medicinal chemistry letters 2004;14(13):3601-5.
2004: Laszlo Revesz; Ernst Blum; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Gerard Rucklin
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.
Bioorganic & medicinal chemistry letters 2004;14(13):3595-9.
2004: Walter Schuler; Marc Bigaud; Volker Brinkmann; Franco E Di Padova; Sabine Geisse; Hermann Gram; Valerie Hungerford; Beate Kleuser; Colette Kristofic; Klaus Menninger; Reet Tees; Grazyna Wieczorek; Corinne Wilt; Catherine Wioland; Mauro Zurini
Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation.
Transplantation 2004;77(5):717-26.
2004: Achim Schlapbach; Richard Heng; Franco E Di Padova
A novel Pd-catalyzed cyclization reaction of ureas for the synthesis of dihydroquinazolinone p38 kinase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(2):357-60.
2003: Bruno Tigani; Franco E Di Padova; Stefan Zurbrügg; Elisabeth Schaeublin; Laszlo Revesz; John R Fozard; Nicolau Beckmann
Effects of a mitogen-activated protein kinase inhibitor on allergic airways inflammation in the rat studied by magnetic resonance imaging.
European journal of pharmacology 2003;482(1-3):319-24.
2003: Sven Muller-Loennies; Lore Brade; C Roger MacKenzie; Franco E Di Padova; Helmut Brade
Identification of a cross-reactive epitope widely present in lipopolysaccharide from enterobacteria and recognized by the cross-protective monoclonal antibody WN1 222-5.
The Journal of biological chemistry 2003;278(28):25618-27.
2002: Laszlo Revesz; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Romain Wolf; Alfred G Zimmerlin
SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(16):2109-12.
2002: Baoxue Ge; Hermann Gram; Franco E Di Padova; Betty Huang; Liguo New; Richard J Ulevitch; Ying Luo; Jiahuai Han
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.
Science (New York, N.Y.) 2002;295(5558):1291-4.
2001: D Le Roy; Franco E Di Padova; Y Adachi; Michel-Pierre Glauser; Thierry Calandra; Didier Heumann
Critical role of lipopolysaccharide-binding protein and CD14 in immune responses against gram-negative bacteria.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2759-65.
2001: W Zhu; MA Brauchle; Franco E Di Padova; Hermann Gram; Liguo New; Koh Ono; JS Downey; Jiahuai Han
Gene suppression by tristetraprolin and release by the p38 pathway.
American journal of physiology. Lung cellular and molecular physiology 2001;281(2):L499-508.
2000: MA Brauchle; D Glück; Franco E Di Padova; Jiahuai Han; Hermann Gram
Independent role of p38 and ERK1/2 mitogen-activated kinases in the upregulation of matrix metalloproteinase-1.
Experimental cell research 2000;258(1):135-44.
2000: W Zhu; JS Downey; J Gu; Franco E Di Padova; Hermann Gram; Jiahuai Han
Regulation of TNF expression by multiple mitogen-activated protein kinase pathways.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6349-58.
2000: Laszlo Revesz; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Alfred G Zimmerlin
SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(11):1261-4.
2000: Colleen Fearns; Lawrence E Kline; Hermann Gram; Franco E Di Padova; Mauro Zurini; Jiahuai Han; Richard J Ulevitch
Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli.
Journal of leukocyte biology 2000;67(5):705-11.
1999: D Le Roy; Franco E Di Padova; R Tees; Sylvain Lengacher; R Landmann; Michel-Pierre Glauser; Thierry Calandra; Didier Heumann
Monoclonal antibodies to murine lipopolysaccharide (LPS)-binding protein (LBP) protect mice from lethal endotoxemia by blocking either the binding of LPS to LBP or the presentation of LPS/LBP complexes to CD14.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7454-60.
1999: M Zhao; Liguo New; Vladimir V Kravchenko; Y Kato; Hermann Gram; Franco E Di Padova; E N Olson; Richard J Ulevitch; Jiahuai Han
Regulation of the MEF2 family of transcription factors by p38.
Molecular and cellular biology 1999;19(1):21-30.
1997: Yong Jiang; Hermann Gram; M Zhao; Liguo New; J Gu; L Feng; Franco E Di Padova; Richard J Ulevitch; Jiahuai Han
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta.
The Journal of biological chemistry 1997;272(48):30122-8.
1997: Bernhard RYFFEL; Franco E Di Padova; MH Schreier; Michel Le Hir; Hans-Pietro Eugster; Valerie QUESNIAUX
Lack of type 2 T cell-independent B cell responses and defect in isotype switching in TNF-lymphotoxin alpha-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2126-33.
1997: S Bailat; Didier Heumann; D Le Roy; JD Baumgartner; E T Rietschel; Michel-Pierre Glauser; Franco E Di Padova
Similarities and disparities between core-specific and O-side-chain-specific antilipopolysaccharide monoclonal antibodies in models of endotoxemia and bacteremia in mice.
Infection and immunity 1997;65(2):811-4.