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Paolo Di Simplicio

Research Profile

Chemicals & Drugs

Phenomena

Oxidation-Reduction

Living Beings

Rats

Anatomy

Disorders

Oxidative Stress

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Protein Conformation

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Publications

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Raffaella Priora; Domenico Summa; Carlo Aldinucci; Lucia Coppo; Danila Di Giuseppe; Anna Di Stefano; Simona Frosali; Antonios Margaritis; Gianpaolo Pessina; Paolo Di Simplicio
In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways.
ottavia spiga; Domenico Summa; Simone Cirri; Andrea Bernini; Vincenzo Venditti; Matteo De Chiara; Raffaella Priora; Simona Frosali; Antonios Margaritis; Danila Di Giuseppe; Paolo Di Simplicio; Neri Niccolai
A structurally driven analysis of thiol reactivity in mammalian albumins.
Antonios Margaritis; Raffaella Priora; Simona Frosali; Danila Di Giuseppe; Domenico Summa; Lucia Coppo; Anna Di Stefano; Paolo Di Simplicio
The role of protein sulfhydryl groups and protein disulfides of the platelet surface in aggregation processes involving thiol exchange reactions.

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All Publications

2011: Raffaella Priora; Domenico Summa; Carlo Aldinucci; Lucia Coppo; Danila Di Giuseppe; Anna Di Stefano; Simona Frosali; Antonios Margaritis; Gianpaolo Pessina; Paolo Di Simplicio
In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;64(3):289-97.
2011: ottavia spiga; Domenico Summa; Simone Cirri; Andrea Bernini; Vincenzo Venditti; Matteo De Chiara; Raffaella Priora; Simona Frosali; Antonios Margaritis; Danila Di Giuseppe; Paolo Di Simplicio; Neri Niccolai
A structurally driven analysis of thiol reactivity in mammalian albumins.
Biopolymers 2011;95(4):278-85.
2011: Antonios Margaritis; Raffaella Priora; Simona Frosali; Danila Di Giuseppe; Domenico Summa; Lucia Coppo; Anna Di Stefano; Paolo Di Simplicio
The role of protein sulfhydryl groups and protein disulfides of the platelet surface in aggregation processes involving thiol exchange reactions.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;63(1):77-84.
2010: Danila Di Giuseppe; Monica Ulivelli; Sabina Bartalini; Stefania Battistini; Alfonso CERASE; Stefano Passero; Domenico Summa; Simona Frosali; Raffaella Priora; Antonios Margaritis; Paolo Di Simplicio
Regulation of redox forms of plasma thiols by albumin in multiple sclerosis after fasting and methionine loading test.
Amino acids 2010;38(5):1461-71.
2010: Raffaella Priora; Lucia Coppo; Antonios Margaritis; Danila Di Giuseppe; Simona Frosali; Domenico Summa; Jongyun Heo; Paolo Di Simplicio
The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats.
Toxicology and applied pharmacology 2010;242(3):333-43.
2010: Raffaella Priora; Lucia Coppo; Sonia Salzano; Paolo Di Simplicio; Pietro Ghezzi
Measurement of mixed disulfides including glutathionylated proteins.
Methods in enzymology 2010;473():149-59.
2009: Simona Frosali; Alessandra Leonini; Anna Ettorre; Giuseppe Di Maio; Sandra Nuti; Simona Tavarini; Paolo Di Simplicio; Anna Di Stefano
Role of intracellular calcium and S-glutathionylation in cell death induced by a mixture of isothiazolinones in HL60 cells.
Biochimica et biophysica acta 2009;1793(3):572-83.
2008: Raffaella Priora; Domenico Summa; Simona Frosali; Antonios Margaritis; Danila Di Giuseppe; Chiara Lapucci; Francesca Ieri; Fabio M Pulcinelli; Annalisa Romani; Flavia Franconi; Paolo Di Simplicio
Administration of minor polar compound-enriched extra virgin olive oil decreases platelet aggregation and the plasma concentration of reduced homocysteine in rats.
The Journal of nutrition 2008;138(1):36-41.
2007: Domenico Summa; ottavia spiga; Andrea Bernini; Vincenzo Venditti; Raffaella Priora; Simona Frosali; Antonios Margaritis; Danila Di Giuseppe; Neri Niccolai; Paolo Di Simplicio
Protein-thiol substitution or protein dethiolation by thiol/disulfide exchange reactions: the albumin model.
Proteins 2007;69(2):369-78.
2007: Pietro Ghezzi; Paolo Di Simplicio
Glutathionylation pathways in drug response.
Current opinion in pharmacology 2007;7(4):398-403.
2006: Anna Di Stefano; Simona Frosali; Alessandra Leonini; Anna Ettorre; Raffaella Priora; Francesca Cherubini Di Simplicio; Paolo Di Simplicio
GSH depletion, protein S-glutathionylation and mitochondrial transmembrane potential hyperpolarization are early events in initiation of cell death induced by a mixture of isothiazolinones in HL60 cells.
Biochimica et biophysica acta 2006;1763(2):214-25.
2005: Paolo Di Simplicio; Simona Frosali; Raffaella Priora; Domenico Summa; Francesca Cherubini Di Simplicio; Danila Di Giuseppe; Anna Di Stefano
Biochemical and biological aspects of protein thiolation in cells and plasma.
Antioxidants & redox signaling 2005;7(7-8):951-63.
2005: Daniela Giustarini; Sauro Lorenzini; R Rossi; D Chindamo; Paolo Di Simplicio; Roberto Marcolongo
Altered thiol pattern in plasma of subjects affected by rheumatoid arthritis.
Clinical and experimental rheumatology 2005;23(2):205-12.
2004: Danila Di Giuseppe; Simona Frosali; Raffaella Priora; Francesca Cherubini Di Simplicio; Giuseppe Buonocore; Carla Cellesi; Pier Leopoldo Capecchi; Franco Laghi Pasini; Pietro Enea Lazzerini; Hieronim Jakubowski; Paolo Di Simplicio
The effects of age and hyperhomocysteinemia on the redox forms of plasma thiols.
The Journal of laboratory and clinical medicine 2004;144(5):235-45.
2004: Simona Frosali; Paolo Di Simplicio; Serafina Perrone; Danila Di Giuseppe; Mariangela Longini; Donatella Tanganelli; Giuseppe Buonocore
Glutathione recycling and antioxidant enzyme activities in erythrocytes of term and preterm newborns at birth.
Biology of the neonate 2004;85(3):188-94.
2003: Paolo Di Simplicio; Flavia Franconi; S Frosalí; Danila Di Giuseppe
Thiolation and nitrosation of cysteines in biological fluids and cells.
Amino acids 2003;25(3-4):323-39.
2003: Mauro Miceli; Luisa Alberti; Federico Bennardini; Paolo Di Simplicio; Giuseppe Seghieri; Gundu H R Rao; Flavia Franconi
Effect of low doses of ethanol on platelet function in long-life abstainers and moderate-wine drinkers.
Life sciences 2003;73(12):1557-66.
2003: Danila Di Giuseppe; Paolo Di Simplicio; Pier Leopoldo Capecchi; Pietro Enea Lazzerini; Franco Laghi Pasini
Alteration in the redox state of plasma in heart-transplant patients with moderate hyperhomocysteinemia.
The Journal of laboratory and clinical medicine 2003;142(1):21-8.
2002: Ranieri Rossi; Aldo Milzani; Isabella Dalle-Donne; Daniela Giustarini; Lorenzo Lusini; Roberto Colombo; Paolo Di Simplicio
Blood glutathione disulfide: in vivo factor or in vitro artifact?
Clinical chemistry 2002;48(5):742-53.
2002: Isabella Dalle-Donne; Ranieri Rossi; Daniela Giustarini; Nicoletta Gagliano; Paolo Di Simplicio; Roberto Colombo; Aldo Milzani
Methionine oxidation as a major cause of the functional impairment of oxidized actin.
Free radical biology & medicine 2002;32(9):927-37.
2001: Isabella Dalle-Donne; Ranieri Rossi; Aldo Milzani; Paolo Di Simplicio; Roberto Colombo
The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself.
Free radical biology & medicine 2001;31(12):1624-32.
2001: R Rossi; Daniela Giustarini; Aldo Milzani; R Colombo; Isabella Dalle-Donne; Paolo Di Simplicio
Physiological levels of S-nitrosothiols in human plasma.
Circulation research 2001;89(12):E47.
2001: Isabella Dalle-Donne; Ranieri Rossi; Daniela Giustarini; Nicoletta Gagliano; Lorenzo Lusini; Aldo Milzani; Paolo Di Simplicio; Roberto Colombo
Actin carbonylation: from a simple marker of protein oxidation to relevant signs of severe functional impairment.
Free radical biology & medicine 2001;31(9):1075-83.
2001: Giuseppe Seghieri; Paolo Di Simplicio; Roberto Anichini; Lorenzo Alviggi; Alessandra De Bellis; Federico Bennardini; Flavia Franconi
Platelet antioxidant enzymes in insulin-dependent diabetes mellitus.
Clinica chimica acta; international journal of clinical chemistry 2001;309(1):19-23.
2001: Fabiola Giannerini; Daniela Giustarini; Lorenzo Lusini; Ranieri Rossi; Paolo Di Simplicio
Responses of thiols to an oxidant challenge: differences between blood and tissues in the rat.
Chemico-biological interactions 2001;134(1):73-85.
2001: Ranieri Rossi; Aldo Milzani; Isabella Dalle-Donne; Fabiola Giannerini; Daniela Giustarini; Lorenzo Lusini; Roberto Colombo; Paolo Di Simplicio
Different metabolizing ability of thiol reactants in human and rat blood: biochemical and pharmacological implications.
The Journal of biological chemistry 2001;276(10):7004-10.
2001: Lorenzo Lusini; Sergio Antonio Tripodi; Ranieri Rossi; Fabiola Giannerini; Daniela Giustarini; Maria Teresa del Vecchio; Gabriele Barbanti; Marcella Cintorino; Piero Tosi; Paolo Di Simplicio
Altered glutathione anti-oxidant metabolism during tumor progression in human renal-cell carcinoma.
International journal of cancer. Journal international du cancer 2001;91(1):55-9.
2000: Aldo Milzani; R Rossi; Paolo Di Simplicio; Daniela Giustarini; Roberto Colombo; I DalleDonne
The oxidation produced by hydrogen peroxide on Ca-ATP-G-actin.
Protein science : a publication of the Protein Society 2000;9(9):1774-82.
2000: Giuseppe Seghieri; Paolo Di Simplicio; L A De Giorgio; Roberto Anichini; L Alberti; Flavia Franconi
Relationship between metabolic glycaemic control and platelet content of glutathione and its related enzymes, in insulin-dependent diabetes mellitus.
Clinica chimica acta; international journal of clinical chemistry 2000;299(1-2):109-17.
2000: Daniela Giustarini; Giuseppe Campoccia; Giuseppe Fanetti; Ranieri Rossi; Fabiola Giannerini; Lorenzo Lusini; Paolo Di Simplicio
Minor thiols cysteine and cysteinylglycine regulate the competition between glutathione and protein SH groups in human platelets subjected to oxidative stress.
Archives of biochemistry and biophysics 2000;380(1):1-10.
2000: Isabella Dalle-Donne; Aldo Milzani; Daniela Giustarini; Paolo Di Simplicio; R Colombo; R Rossi
S-NO-actin: S-nitrosylation kinetics and the effect on isolated vascular smooth muscle.
Journal of muscle research and cell motility 2000;21(2):171-81.
1999: Velio Bocci; Nicola Di Paolo; Guido Garosi; Carlo Aldinucci; Emma Borrelli; Giuseppe Valacchi; F Cappelli; L Guerri; G Gavioli; Fausto Corradeschi; Ranieri Rossi; Fabiola Giannerini; Paolo Di Simplicio
Ozonation of blood during extracorporeal circulation. I. Rationale, methodology and preliminary studies.
The International journal of artificial organs 1999;22(9):645-51.
1999: Gábor Bánhegyi; Lorenzo Lusini; F Puskás; Ranieri Rossi; Rosella Fulceri; László Braun; Valéria Mile; Paolo Di Simplicio; József Mandl; Angelo Benedetti
Preferential transport of glutathione versus glutathione disulfide in rat liver microsomal vesicles.
The Journal of biological chemistry 1999;274(18):12213-6.
1999: Velio Bocci; Giuseppe Valacchi; R Rossi; Daniela Giustarini; Eugenio Paccagnini; A M Pucci; Paolo Di Simplicio
Studies on the biological effects of ozone: 9. Effects of ozone on human platelets.
Platelets 1999;10(2-3):110-6.
1998: Ranieri Rossi; D Barra; Andrea Bellelli; Giovanna Boumis; S Canofeni; Paolo Di Simplicio; Lorenzo Lusini; S Pascarella; Gino Amiconi
Fast-reacting thiols in rat hemoglobins can intercept damaging species in erythrocytes more efficiently than glutathione.
The Journal of biological chemistry 1998;273(30):19198-206.
1998: Paolo Di Simplicio; M G Cacace; Lorenzo Lusini; Fabiola Giannerini; Daniela Giustarini; Ranieri Rossi
Role of protein -SH groups in redox homeostasis--the erythrocyte as a model system.
Archives of biochemistry and biophysics 1998;355(2):145-52.
1998: Paolo Di Simplicio; Fabiola Giannerini; Daniela Giustarini; Lorenzo Lusini; Ranieri Rossi
The role of cysteine in the regulation of blood glutathione-protein mixed disulfides in rats treated with diamide.
Toxicology and applied pharmacology 1998;148(1):56-64.
1997: Ranieri Rossi; Lorenzo Lusini; Fabiola Giannerini; Daniela Giustarini; Giuseppe Lungarella; Paolo Di Simplicio
A method to study kinetics of transnitrosation with nitrosoglutathione: reactions with hemoglobin and other thiols.
Analytical biochemistry 1997;254(2):215-20.
1997: Eleonora Cavarra; Piero Martorana; S Cortese; Federica Gambelli; Paolo Di Simplicio; Giuseppe Lungarella
Neutrophils in beige mice secrete normal amounts of cathepsin G and a 46 kDa latent form of elastase that can be activated extracellularly by proteolytic activity.
Biological chemistry 1997;378(5):417-23.
1997: Paolo Di Simplicio; R Rossi; S Falcinelli; R Ceserani; M L Formento
Antioxidant status in various tissues of the mouse after fasting and swimming stress.
European journal of applied physiology and occupational physiology 1997;76(4):302-7.
1996: Paolo Di Simplicio; E Lupis; R Rossi
Different mechanisms of formation of glutathione-protein mixed disulfides of diamide and tert-butyl hydroperoxide in rat blood.
Biochimica et biophysica acta 1996;1289(2):252-60.
1995: Paolo Di Simplicio; L A de Giorgio; Elena Cardaioli; R Lecis; M Miceli; R Rossi; Roberto Anichini; M Mian; Giuseppe Seghieri; Flavia Franconi
Glutathione, glutathione utilizing enzymes and thioltransferase in platelets of insulin-dependent diabetic patients: relation with platelet aggregation and with microangiopatic complications.
European journal of clinical investigation 1995;25(9):665-9.
1995: R Rossi; Elena Cardaioli; A Scaloni; Gino Amiconi; Paolo Di Simplicio
Thiol groups in proteins as endogenous reductants to determine glutathione-protein mixed disulphides in biological systems.
Biochimica et biophysica acta 1995;1243(2):230-8.
1994: Paolo Di Simplicio; R Rossi
The time-course of mixed disulfide formation between GSH and proteins in rat blood after oxidative stress with tert-butyl hydroperoxide.
Biochimica et biophysica acta 1994;1199(3):245-52.
1993: Velio Bocci; E Luzzi; Fausto Corradeschi; Luana Paulesu; R Rossi; Elena Cardaioli; Paolo Di Simplicio
Studies on the biological effects of ozone: 4. Cytokine production and glutathione levels in human erythrocytes.
Journal of biological regulators and homeostatic agents 1993;7(4):133-8.
1993: Paolo Di Simplicio; M Gorelli; R Vignani; Claudio Leonzio
The differential modulation of the enzymes of glutathione metabolism. Indication of overlapping effects of toxicity and repair in mouse liver and kidney after dietary treatment with methyl mercury and sodium selenite.
Biological trace element research 1993;36(2):167-81.
1992: Antonella Mattana; C Juliano; Federico Bennardini; M Mignano; S Marceddu; V Picci; Paolo Di Simplicio; Flavia Franconi
Hydrogen peroxide-induced cytotoxicity in cultured epithelial cells (WISH): A functional and morphological study.
Toxicology in vitro : an international journal published in association with BIBRA 1992;6(6):533-41.
1992: Rita Vignani; C Milanesi; Paolo Di Simplicio
Disruption of cytoskeleton by methylmercury in cultured CHO cells.
Toxicology in vitro : an international journal published in association with BIBRA 1992;6(1):61-70.
1991: Paolo Di Simplicio; K H Cheeseman; T F Slater
The reactivity of the SH group of bovine serum albumin with free radicals.
Free radical research communications 1991;14(4):253-62.
1990: R Vignani; M Gorelli; Paolo Di Simplicio
The effect of methyl mercury on cytoskeleton and glutathione-dependent enzymes of CHO cultured cells.
Pharmacological research : the official journal of the Italian Pharmacological Society 1990;22 Suppl 1():45-6.
1990: Paolo Di Simplicio; M Gorelli; P Ciuffreda; Claudio Leonzio
The relationship between gamma-glutamyl transpeptidase and Hg levels in Se/Hg antagonism in mouse liver and kidney.
Pharmacological research : the official journal of the Italian Pharmacological Society 1990;22(4):515-26.
1990: Giancarlo Bruni; Paolo Di Simplicio; Renato Urso; G Segre
Triazolam pharmacokinetics in rats using a radioreceptor assay.
International journal of clinical pharmacology research 1990;10(4):217-21.
1989: Paolo Di Simplicio; H Jensson; B Mannervik
Effects of inducers of drug metabolism on basic hepatic forms of mouse glutathione transferase.
The Biochemical journal 1989;263(3):679-85.
1989: Paolo Di Simplicio; A Tiezzi; A Moscatelli; M T Bianco; M Cresti
The SH-SS exchange reaction between the Ellman's reagent and protein containing SH groups as a method for determining conformational states: tubulin.
The Italian journal of biochemistry 1989;38(2):83-90.
1989: Paolo Di Simplicio; Claudio Leonzio
Effects of selenium and mercury on glutathione and glutathione-dependent enzymes in experimental quail.
Bulletin of environmental contamination and toxicology 1989;42(1):15-21.
1984: Paolo Di Simplicio; A Naldini; M T Bianco
[Relation between glutathione and cytoplasmic protein sulfhydryl groups in the rat: a rapid procedure for analytical determination].
Bollettino della Società italiana di biologia sperimentale 1984;60(6):1161-7.
1983: Paolo Di Simplicio; H Jensson; B Mannervik
Identification of the isozymes of glutathione transferase induced by trans-stilbene oxide.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 1983;37(3):255-7.
1980: Paolo Di Simplicio; Mitri Palmi; P Ruggiero; G Segre
[Glutathione-S-transferase and glutathione in the liver and blood of rats poisoned by thioacetamide].
Bollettino della Società italiana di biologia sperimentale 1980;56(8):795-801.