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Francesco Di Virgilio

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Francesco Di Virgilio
The therapeutic potential of modifying inflammasomes and NOD-like receptors.
Paola Caccin; Mariana Cintra-Francischinelli; Francesco Di Virgilio; Julián Fernandez; José María Gutiérrez; Bruno Lomonte; Patrizia Pellegatti; Maria Vono; Cesare Montecucco
Why myotoxin-containing snake venoms possess powerful nucleotidases?
Sara Gulinelli; Marco Idzko; Cinzia Pizzirani; Erica Salaro; Marta Vuerich; Giorgio Bolognesi; Dania Bozzato; Francesco Di Virgilio; Davide Ferrari
IL-18 associates to microvesicles shed from human macrophages by a LPS/TLR-4 independent mechanism in response to P2X receptor stimulation.

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All Publications

2013: Francesco Di Virgilio
The therapeutic potential of modifying inflammasomes and NOD-like receptors.
Pharmacological reviews 2013;65(3):872-905.
2013: Paola Caccin; Mariana Cintra-Francischinelli; Francesco Di Virgilio; Julián Fernandez; José María Gutiérrez; Bruno Lomonte; Patrizia Pellegatti; Maria Vono; Cesare Montecucco
Why myotoxin-containing snake venoms possess powerful nucleotidases?
Biochemical and biophysical research communications 2013;430(4):1289-93.
2012: Sara Gulinelli; Marco Idzko; Cinzia Pizzirani; Erica Salaro; Marta Vuerich; Giorgio Bolognesi; Dania Bozzato; Francesco Di Virgilio; Davide Ferrari
IL-18 associates to microvesicles shed from human macrophages by a LPS/TLR-4 independent mechanism in response to P2X receptor stimulation.
European journal of immunology 2012;42(12):3334-45.
2012: Cemil Korcan Ayata; Jean-Marie Boeynaems; Francesco Di Virgilio; Andreas Diefenbach; Stephanie C Ganal; Melanie Grimm; Birgit Hockenjos; Marco Idzko; Patrizia Pellegatti; Bernard Robaye; Rodolfo P Vieira; Karolina Willim; Peter Hasselblatt
Purinergic P2Y₂ receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury.
Gastroenterology 2012;143(6):1620-1629.e4.
2012: Francesco Di Virgilio
Purines, purinergic receptors, and cancer.
Cancer research 2012;72(21):5441-7.
2012: Lara Rossi; Valentina Salvestrini; Francesco Di Virgilio; Davide Ferrari; Roberto M Lemoli
The sixth sense: hematopoietic stem cells detect danger through purinergic signaling.
Blood 2012;120(12):2365-75.
2012: Sara Trabanelli; Rodolfo de Paula Vieira; Darina Ocadlíková; Valentina Salvestrini; Antonio Curti; Francesco Di Virgilio; Davide Ferrari; Sara Gulinelli; Marco Idzko; Roberto M Lemoli
Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(3):1303-10.
2012: F Amoroso; Simonetta Falzoni; Davide Ferrari; Elena Adinolfi; Francesco Di Virgilio
The P2X7 receptor is a key modulator of aerobic glycolysis.
Cell death & disease 2012;3():e370.
2012: Elisabeth Panther; Stephan Sorichter; Johannes Norgauer; Sanja Cicko; Francesco Di Virgilio; Thorsten Dürk; Davide Ferrari; Melanie Grimm; Yared Herouy; Marco Idzko; Tobias Müller
AMP affects intracellular Ca2+ signaling, migration, cytokine secretion and T cell priming capacity of dendritic cells.
PloS one 2012;7(5):e37560.
2011: Irma Lemaire; Patrizia Pellegatti; Bin Zhang; Simonetta Falzoni; Francesco Di Virgilio
The P2X7 receptor and Pannexin-1 are both required for the promotion of multinucleated macrophages by the inflammatory cytokine GM-CSF.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3878-87.
2011: Patrizia Pellegatti; Simonetta Falzoni; Giovanna Donvito; Irma Lemaire; Francesco Di Virgilio
P2X7 receptor drives osteoclast fusion by increasing the extracellular adenosine concentration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(4):1264-74.
2011: Davide Ferrari; Sara Gulinelli; Valentina Salvestrini; Giovanna Lucchetti; Roberta Zini; Rossella Manfredini; Luisa Caione; Wanda Piacibello; Marilena Ciciarello; Lara Rossi; Marco Idzko; Sergio Ferrari; Francesco Di Virgilio; Roberto M Lemoli
Purinergic stimulation of human mesenchymal stem cells potentiates their chemotactic response to CXCL12 and increases the homing capacity and production of proinflammatory cytokines.
Experimental hematology 2011;39(3):360-74, 374.e1-5.
2011: Monica Lucattelli; Sanja Cicko; Tobias Müller; Marek Lommatzsch; Giovanna De Cunto; Silvia Cardini; William Sundas; Melanie Grimm; Robert Zeiser; Thorsten Dürk; Gernot Zissel; Stephan Sorichter; Davide Ferrari; Francesco Di Virgilio; J Christian Virchow; Giuseppe Lungarella; Marco Idzko
P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysema.
American journal of respiratory cell and molecular biology 2011;44(3):423-9.
2010: Tobias Müller; B Robaye; R P Vieira; Davide Ferrari; M Grimm; T Jakob; S F Martin; Francesco Di Virgilio; J-M Boeynaems; J Christian Virchow; Marco Idzko
The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation.
Allergy 2010;65(12):1545-53.
2010: Elena Adinolfi; Maria Cirillo; Ronja Woltersdorf; Simonetta Falzoni; Paola Chiozzi; Patrizia Pellegatti; Maria Giulia Callegari; Dorianna Sandonà; Fritz Markwardt; Günther Schmalzing; Francesco Di Virgilio
Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(9):3393-404.
2010: Davide Ferrari; Paolo Pinton; Michelangelo Campanella; Maria Giulia Callegari; Cinzia Pizzirani; Alessandro Rimessi; Francesco Di Virgilio; Tullio Pozzan; Rosario Rizzuto
Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation.
Biochemical and biophysical research communications 2010;391(1):575-81.
2009: Roberta Rizzo; Davide Ferrari; Loredana Melchiorri; Marina Stignani; Sara Gulinelli; Olavio R Baricordi; Francesco Di Virgilio
Extracellular ATP acting at the P2X7 receptor inhibits secretion of soluble HLA-G from human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4302-11.
2009: Francesco Di Virgilio; Jean-Marie Boeynaems; Simon C Robson
Extracellular nucleotides as negative modulators of immunity.
Current opinion in pharmacology 2009;9(4):507-13.
2009: Francesco Di Virgilio; James S Wiley
Editorial.
Purinergic signalling 2009;5(2):127-8.
2009: Francesco Di Virgilio; Davide Ferrari; Elena Adinolfi
P2X(7): a growth-promoting receptor-implications for cancer.
Purinergic signalling 2009;5(2):251-6.
2009: Elena Adinolfi; Maria Giulia Callegari; Maria Cirillo; Paolo Pinton; Carlotta Giorgi; Dario Cavagna; Rosario Rizzuto; Francesco Di Virgilio
Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis.
The Journal of biological chemistry 2009;284(15):10120-8.
2009: Juana maria SAnz; Paola Chiozzi; Davide Ferrari; Marilena Colaianna; Marco Idzko; Simonetta Falzoni; Renato Fellin; Luigia Trabace; Francesco Di Virgilio
Activation of microglia by amyloid {beta} requires P2X7 receptor expression.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4378-85.
2009: Francesco Di Virgilio; Stefano Ceruti; Placido Bramanti; Maria P Abbracchio
Purinergic signalling in inflammation of the central nervous system.
Trends in neurosciences 2009;32(2):79-87.
2009: Tobias Müller; Thorsten Dürk; Britta Blumenthal; Melanie Grimm; Sanja Cicko; Elisabeth Panther; Stephan Sorichter; Yared Herouy; Francesco Di Virgilio; Davide Ferrari; Johannes Norgauer; Marco Idzko
5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
PloS one 2009;4(7):e6453.
2008: Daniel Myrtek; Tobias Müller; Verena Geyer; Natalie Derr; Davide Ferrari; Gernot Zissel; Thorsten Dürk; Stephan Sorichter; Werner Luttmann; Michael Kuepper; Johannes Norgauer; Francesco Di Virgilio; J Christian Virchow; Marco Idzko
Activation of human alveolar macrophages via P2 receptors: coupling to intracellular Ca2+ increases and cytokine secretion.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):2181-8.
2008: Patrizia Pellegatti; Lizzia Raffaghello; Giovanna Bianchi; Federica Piccardi; Vito Pistoia; Francesco Di Virgilio
Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase.
PloS one 2008;3(7):e2599.
2008: Anna Solini; Sabina Cuccato; Davide Ferrari; Eleonora Santini; Sara Gulinelli; Maria Giulia Callegari; Angela Dardano; Pinuccia Faviana; Stephanie Madec; Francesco Di Virgilio; Fabio Monzani
Increased P2X7 receptor expression and function in thyroid papillary cancer: a new potential marker of the disease?
Endocrinology 2008;149(1):389-96.
2007: Francesco Di Virgilio
Liaisons dangereuses: P2X(7) and the inflammasome.
Trends in pharmacological sciences 2007;28(9):465-72.
2007: Lo Monaco Andrea; Sara Gulinelli; Gabriella Castellino; Anna Solini; Davide Ferrari; Renato La Corte; Francesco Trotta; Francesco Di Virgilio
Increased sensitivity to extracellular ATP of fibroblasts from patients affected by systemic sclerosis.
Annals of the rheumatic diseases 2007;66(8):1124-5.
2007: Marcello Baroni; Cinzia Pizzirani; Mirko Pinotti; Davide Ferrari; Elena Adinolfi; Sara Calzavarini; Pierpaolo Caruso; francesco bernardi; Francesco Di Virgilio
Stimulation of P2 (P2X7) receptors in human dendritic cells induces the release of tissue factor-bearing microparticles.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(8):1926-33.
2007: Valentina Resta; Elena Novelli; Giovanni Vozzi; Cristiano Scarpa; Matteo Caleo; Arti Ahluwalia; Anna Solini; Eleonora Santini; Vincenzo Parisi; Francesco Di Virgilio; Lucia Galli-Resta
Acute retinal ganglion cell injury caused by intraocular pressure spikes is mediated by endogenous extracellular ATP.
The European journal of neuroscience 2007;25(9):2741-54.
2007: Anna Solini; Eleonora Santini; Daniele Chimenti; Paola Chiozzi; Federico Pratesi; Sabina Cuccato; Simonetta Falzoni; ROBERTO LUPI; Ele Ferrannini; Giuseppe Pugliese; Francesco Di Virgilio
Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4.
American journal of physiology. Renal physiology 2007;292(5):F1537-47.
2007: Cinzia Pizzirani; Davide Ferrari; Paola Chiozzi; Elena Adinolfi; Dorianna Sandonà; Erika Savaglio; Francesco Di Virgilio
Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells.
Blood 2007;109(9):3856-64.
2007: Francesco Di Virgilio
Purinergic signalling in the immune system. A brief update.
Purinergic signalling 2007;3(1-2):1-3.
2007: Saveria Pastore; Francesca Mascia; Sara Gulinelli; Sylvia Forchap; Cristina Dattilo; Elena Adinolfi; Giampiero Girolomoni; Francesco Di Virgilio; Davide Ferrari
Stimulation of purinergic receptors modulates chemokine expression in human keratinocytes.
The Journal of investigative dermatology 2007;127(3):660-7.
2007: Davide Ferrari; Cinzia Pizzirani; Sara Gulinelli; G Callegari; Paola Chiozzi; Marco Idzko; Elisabeth Panther; Francesco Di Virgilio
Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule.
British journal of pharmacology 2007;150(4):445-54.
2007: Lara Rossi; Rossella Manfredini; Francesco Bertolini; Davide Ferrari; Miriam Fogli; Roberta Zini; Simona Salati; Valentina Salvestrini; Sara Gulinelli; Elena Adinolfi; Sergio Ferrari; Francesco Di Virgilio; Michele Baccarani; Roberto M Lemoli
The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration.
Blood 2007;109(2):533-42.
2006: Irma Lemaire; Simonetta Falzoni; Natacha Leduc; Bin Zhang; Patrizia Pellegatti; Elena Adinolfi; Paola Chiozzi; Francesco Di Virgilio
Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7257-65.
2006: Francesco Caciagli; Francesco Di Virgilio
First joint italian-german purine club meeting "progress in purinergic receptor pharmacology and function".
Purinergic signalling 2006;2(4):573-4.
2006: Roberta Placido; Giovanni Auricchio; Simonetta Falzoni; Luca Battistini; Vittorio Colizzi; Ercole Brunetti; Francesco Di Virgilio; Giorgio Mancino
P2X(7) purinergic receptors and extracellular ATP mediate apoptosis of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the intracellular bacterial viability.
Cellular immunology 2006;244(1):10-8.
2006: Fabio Bianco; Stefania Ceruti; Alessio Colombo; Marta Fumagalli; Davide Ferrari; Cinzia Pizzirani; Michela Matteoli; Francesco Di Virgilio; Maria P Abbracchio; Claudia Verderio
A role for P2X7 in microglial proliferation.
Journal of neurochemistry 2006;99(3):745-58.
2006: Davide Ferrari; Cinzia Pizzirani; Elena Adinolfi; Roberto M Lemoli; Antonio Curti; Marco Idzko; Elisabeth Panther; Francesco Di Virgilio
The P2X7 receptor: a key player in IL-1 processing and release.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):3877-83.
2006: Lizzia Raffaghello; Paola Chiozzi; Simonetta Falzoni; Francesco Di Virgilio; Vito Pistoia
The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism.
Cancer research 2006;66(2):907-14.
2006: Francesco Di Virgilio
Purinergic signalling between axons and microglia.
Novartis Foundation symposium 2006;276():253-8; discussion 259-62, 275-81.
2006: Davide Ferrari; Andrea la Sala; Elisabeth Panther; Johannes Norgauer; Francesco Di Virgilio; Marco Idzko
Activation of human eosinophils via P2 receptors: novel findings and future perspectives.
Journal of leukocyte biology 2006;79(1):7-15.
2005: Tobias Müller; Hans Bayer; Daniel Myrtek; Davide Ferrari; Stephan Sorichter; Manfred W Ziegenhagen; Gernot Zissel; J Christian Virchow; Werner Luttmann; Johannes Norgauer; Francesco Di Virgilio; Marco Idzko
The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion.
American journal of respiratory cell and molecular biology 2005;33(6):601-9.
2005: Elena Adinolfi; Cinzia Pizzirani; Marco Idzko; Elisabeth Panther; Johannes Norgauer; Francesco Di Virgilio; Davide Ferrari
P2X(7) receptor: Death or life?
Purinergic signalling 2005;1(3):219-27.
2005: Francesco Di Virgilio
Purinergic mechanism in the immune system: A signal of danger for dendritic cells.
Purinergic signalling 2005;1(3):205-9.
2005: Patrizia Pellegatti; Simonetta Falzoni; Paolo Pinton; Rosario Rizzuto; Francesco Di Virgilio
A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion.
Molecular biology of the cell 2005;16(8):3659-65.
2005: Giulio Cabrini; Simonetta Falzoni; Sylvia Forchap; Patrizia Pellegatti; Alessandra Balboni; Paola Agostini; Antonio Cuneo; Gianluigi Castoldi; Olavio R Baricordi; Francesco Di Virgilio
A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):82-9.
2005: Elena Adinolfi; Maria Giulia Callegari; Davide Ferrari; Chiara Bolognesi; Mattia Minelli; Mariusz R Wieckowski; Paolo Pinton; Rosario Rizzuto; Francesco Di Virgilio
Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth.
Molecular biology of the cell 2005;16(7):3260-72.
2005: Nadia Caraccio; Fabio Monzani; Eleonora Santini; Sabina Cuccato; Davide Ferrari; Maria Giulia Callegari; Sara Gulinelli; Cinzia Pizzirani; Francesco Di Virgilio; Ele Ferrannini; Anna Solini
Extracellular adenosine 5'-triphosphate modulates interleukin-6 production by human thyrocytes through functional purinergic P2 receptors.
Endocrinology 2005;146(7):3172-8.
2005: Valentina Resta; Elena Novelli; Francesco Di Virgilio; Lucia Galli-Resta
Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control.
Development (Cambridge, England) 2005;132(12):2873-82.
2005: Thorsten Dürk; Elisabeth Panther; Tobias Müller; Stephan Sorichter; Davide Ferrari; Cinzia Pizzirani; Francesco Di Virgilio; Daniel Myrtek; Johannes Norgauer; Marco Idzko
5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes.
International immunology 2005;17(5):599-606.
2005: Anna Solini; Carla Iacobini; Carlo Ricci; Paola Chiozzi; Lorena Amadio; Flavia Pricci; Umberto Di Mario; Francesco Di Virgilio; Giuseppe Pugliese
Purinergic modulation of mesangial extracellular matrix production: role in diabetic and other glomerular diseases.
Kidney international 2005;67(3):875-85.
2005: Francesco Di Virgilio; Olavio R Baricordi; LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi
Leukocyte P2 receptors: a novel target for anti-inflammatory and anti-tumor therapy.
Current drug targets. Cardiovascular & haematological disorders 2005;5(1):85-99.
2004: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Maria Giovanna Pavani; Mojgan Aghazadeh Tabrizi; Allan R Moorman; Francesco Di Virgilio; Elena Cattabriga; Cecilia Pancaldi; Stefania Gessi; Pier Andrea Borea
Synthesis, radiolabeling, and preliminary biological evaluation of [3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl]-4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor.
Bioorganic & medicinal chemistry letters 2004;14(22):5709-12.
2004: Davide Ferrari; Cinzia Pizzirani; Elena Adinolfi; Sylvia Forchap; Barbara Sitta; Laura Turchet; Simonetta Falzoni; Mattia Minelli; Roberto Baricordi; Francesco Di Virgilio
The antibiotic polymyxin B modulates P2X7 receptor function.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4652-60.
2004: Roberto M Lemoli; Davide Ferrari; Miriam Fogli; Lara Rossi; Cinzia Pizzirani; Sylvia Forchap; Paola Chiozzi; Diletta Vaselli; Francesco Bertolini; Thomas Foutz; Michela Aluigi; Michele Baccarani; Francesco Di Virgilio
Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo.
Blood 2004;104(6):1662-70.
2004: Anna Solini; Paola Chiozzi; Anna Morelli; Elena Adinolfi; Roberta Rizzo; Olavio R Baricordi; Francesco Di Virgilio
Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(7):1240-5.
2004: Marco Idzko; Elisabeth Panther; Christian Stratz; Tobias Müller; Hans Bayer; Gernot Zissel; Thorsten Dürk; Stephan Sorichter; Francesco Di Virgilio; Michael Geissler; Bernd L Fiebich; Yared Herouy; Peter Elsner; Johannes Norgauer; Davide Ferrari
The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6011-9.
2004: Pier Giovanni Baraldi; Francesco Di Virgilio; LUISA-CARLOTA LÓPEZ-CARA
Agonists and antagonists acting at P2X7 receptor.
Current topics in medicinal chemistry 2004;4(16):1707-17.
2003: Anna Solini; Paola Chiozzi; Anna Morelli; Angelina Passaro; Renato Fellin; Francesco Di Virgilio
Defective P2Y purinergic receptor function: A possible novel mechanism for impaired glucose transport.
Journal of cellular physiology 2003;197(3):435-44.
2003: Rosario Rizzuto; Paolo Pinton; Davide Ferrari; MOUNIA CHAMI; Gyorgy Szabadkai; Paulo J Magalhães; Francesco Di Virgilio; Tullio Pozzan
Calcium and apoptosis: facts and hypotheses.
Oncogene 2003;22(53):8619-27.
2003: Francesco Di Virgilio
Novel data point to a broader mechanism of action of oxidized ATP: the P2X7 receptor is not the only target.
British journal of pharmacology 2003;140(3):441-3.
2003: Elena Adinolfi; Miran Kim; Mark T Young; Francesco Di Virgilio; Annmarie Surprenant
Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors.
The Journal of biological chemistry 2003;278(39):37344-51.
2003: Anna Morelli; Paola Chiozzi; Anna Chiesa; Davide Ferrari; Juana maria SAnz; Simonetta Falzoni; Paolo Pinton; Rosario Rizzuto; Michael F Olson; Francesco Di Virgilio
Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells.
Molecular biology of the cell 2003;14(7):2655-64.
2003: Pier Giovanni Baraldi; Maria del Carmen Nuñez; Anna Morelli; Simonetta Falzoni; Francesco Di Virgilio; Romeo Romagnoli
Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.
Journal of medicinal chemistry 2003;46(8):1318-29.
2003: Marco Idzko; Elisabeth Panther; Hinrich C Bremer; Stephan Sorichter; Werner Luttmann; Christian Virchow; Francesco Di Virgilio; Yared Herouy; Johannes Norgauer; Davide Ferrari
Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils.
British journal of pharmacology 2003;138(7):1244-50.
2003: Andrea la Sala; Davide Ferrari; Francesco Di Virgilio; Marco Idzko; Johannes Norgauer; Giampiero Girolomoni
Alerting and tuning the immune response by extracellular nucleotides.
Journal of leukocyte biology 2003;73(3):339-43.
2002: Francesco Di Virgilio; James S Wiley
The P2X7 receptor of CLL lymphocytes-a molecule with a split personality.
Lancet 2002;360(9349):1898-9.
2002: Elisabeth Panther; Marco Idzko; Silvia Corinti; Davide Ferrari; Yared Herouy; Maja Mockenhaupt; Stefan Dichmann; Peter J Gebicke-Haerter; Francesco Di Virgilio; Giampiero Girolomoni; Johannes Norgauer
The influence of lysophosphatidic acid on the functions of human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4129-35.
2002: Marco Idzko; Stefan Dichmann; Davide Ferrari; Francesco Di Virgilio; Andrea la Sala; Giampiero Girolomoni; Elisabeth Panther; Johannes Norgauer
Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors.
Blood 2002;100(3):925-32.
2002: Marco Idzko; Andrea la Sala; Davide Ferrari; Elisabeth Panther; Yared Herouy; Stefan Dichmann; Maja Mockenhaupt; Francesco Di Virgilio; Giampiero Girolomoni; Johannes Norgauer
Expression and function of histamine receptors in human monocyte-derived dendritic cells.
The Journal of allergy and clinical immunology 2002;109(5):839-46.
2002: Marco Idzko; Elisabeth Panther; Silvia Corinti; Anna Morelli; Davide Ferrari; Yared Herouy; Stefan Dichmann; Maja Mockenhaupt; Peter J Gebicke-Haerter; Francesco Di Virgilio; Giampiero Girolomoni; Johannes Norgauer
Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(6):625-7.
2002: Andrea la Sala; Silvia Sebastiani; Davide Ferrari; Francesco Di Virgilio; Marco Idzko; Johannes Norgauer; Giampiero Girolomoni
Dendritic cells exposed to extracellular adenosine triphosphate acquire the migratory properties of mature cells and show a reduced capacity to attract type 1 T lymphocytes.
Blood 2002;99(5):1715-22.
2002: Francesco Di Virgilio; Anna Solini
P2 receptors: new potential players in atherosclerosis.
British journal of pharmacology 2002;135(4):831-42.
2002: Elena Adinolfi; Loredana Melchiorri; Simonetta Falzoni; Paola Chiozzi; Anna Morelli; Alessia Tieghi; Antonio Cuneo; Gianluigi Castoldi; Francesco Di Virgilio; Olavio R Baricordi
P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia.
Blood 2002;99(2):706-8.
2002: Pier Giovanni Baraldi; Rimma Makaeva; Maria Giovanna Pavani; Maria del Carmen Nuñez; Giampiero Spalluto; Stefano Moro; Simonetta Falzoni; Francesco Di Virgilio; LUISA-CARLOTA LÓPEZ-CARA
Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety.
Arzneimittel-Forschung 2002;52(4):273-85.
2001: Marco Idzko; Stefan Dichmann; Elisabeth Panther; Davide Ferrari; Yared Herouy; Christian Virchow; Werner Luttmann; Francesco Di Virgilio; Johannes Norgauer
Functional characterization of P2Y and P2X receptors in human eosinophils.
Journal of cellular physiology 2001;188(3):329-36.
2001: Giorgio Mancino; Roberta Placido; Francesco Di Virgilio
P2X7 receptors and apoptosis in tuberculosis infection.
Journal of biological regulators and homeostatic agents 2001;15(3):286-93.
2001: Anna Solini; Francesco Di Virgilio; Paola Chiozzi; Paola Fioretto; Angelina Passaro; Renato Fellin
A defect in glycogen synthesis characterizes insulin resistance in hypertensive patients with type 2 diabetes.
Hypertension 2001;37(6):1492-6.
2001: Andrea la Sala; Davide Ferrari; Silvia Corinti; Andrea Cavani; Francesco Di Virgilio; Giampiero Girolomoni
Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1611-7.
2001: Francesco Di Virgilio; Paola Chiozzi; Davide Ferrari; Simonetta Falzoni; Juana maria SAnz; Anna Morelli; M Torboli; G Bolognesi; Olavio R Baricordi
Nucleotide receptors: an emerging family of regulatory molecules in blood cells.
Blood 2001;97(3):587-600.
2001: Francesco Di Virgilio; Pier Andrea Borea; Peter Illes
P2 receptors meet the immune system.
Trends in pharmacological sciences 2001;22(1):5-7.
2000: Davide Ferrari; Marco Idzko; Stefan Dichmann; D Purlis; Christian Virchow; Johannes Norgauer; Paola Chiozzi; Francesco Di Virgilio; Werner Luttmann
P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production.
FEBS letters 2000;486(3):217-24.
2000: Davide Ferrari; Andrea la Sala; Paola Chiozzi; Antonio Morelli; Simonetta Falzoni; Giampiero Girolomoni; Marco Idzko; Stefan Dichmann; Johannes Norgauer; Francesco Di Virgilio
The P2 purinergic receptors of human dendritic cells: identification and coupling to cytokine release.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(15):2466-76.
2000: Anna Solini; Paola Chiozzi; Simonetta Falzoni; A Morelli; Renato Fellin; Francesco Di Virgilio
High glucose modulates P2X7 receptor-mediated function in human primary fibroblasts.
Diabetologia 2000;43(10):1248-56.
2000: Simonetta Falzoni; Paola Chiozzi; Davide Ferrari; Gary N Buell; Francesco Di Virgilio
P2X(7) receptor and polykarion formation.
Molecular biology of the cell 2000;11(9):3169-76.
2000: Juana maria SAnz; Francesco Di Virgilio
Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4893-8.
2000: Pier Giovanni Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Mojgan Aghazadeh Tabrizi; Simonetta Falzoni; Francesco Di Virgilio
Synthesis of conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor.
Bioorganic & medicinal chemistry letters 2000;10(7):681-4.
2000: Paolo Pinton; Davide Ferrari; P Magalhães; K Schulze-Osthoff; Francesco Di Virgilio; Tullio Pozzan; Rosario Rizzuto
Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.
The Journal of cell biology 2000;148(5):857-62.
2000: Stefan Dichmann; Marco Idzko; U Zimpfer; C Hofmann; Davide Ferrari; Werner Luttmann; Christian Virchow; Francesco Di Virgilio; Johannes Norgauer
Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca(++) mobilization and actin reorganization in human eosinophils.
Blood 2000;95(3):973-8.
1999: Olavio R Baricordi; Loredana Melchiorri; Elena Adinolfi; Simonetta Falzoni; Paola Chiozzi; Gary N Buell; Francesco Di Virgilio
Increased proliferation rate of lymphoid cells transfected with the P2X(7) ATP receptor.
The Journal of biological chemistry 1999;274(47):33206-8.
1999: Francesco Di Virgilio; Simonetta Falzoni; Paola Chiozzi; Juana maria SAnz; Davide Ferrari; Gary N Buell
ATP receptors and giant cell formation.
Journal of leukocyte biology 1999;66(5):723-6.
1999: C Mutini; Simonetta Falzoni; Davide Ferrari; Paola Chiozzi; Antonio Morelli; Olavio R Baricordi; G Collo; P Ricciardi-Castagnoli; Francesco Di Virgilio
Mouse dendritic cells express the P2X7 purinergic receptor: characterization and possible participation in antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1958-65.
1999: Anna Solini; Paola Chiozzi; A Morelli; Renato Fellin; Francesco Di Virgilio
Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release.
Journal of cell science 1999;112 ( Pt 3)():297-305.
1999: Francesco Di Virgilio; Juana maria SAnz; Paola Chiozzi; Simonetta Falzoni
The P2Z/P2X7 receptor of microglial cells: a novel immunomodulatory receptor.
Progress in brain research 1999;120():355-68.
1998: Juana maria SAnz; Paola Chiozzi; Francesco Di Virgilio
Tenidap enhances P2Z/P2X7 receptor signalling in macrophages.
European journal of pharmacology 1998;355(2-3):235-44.
1998: Francesco Di Virgilio; Paola Chiozzi; Simonetta Falzoni; Davide Ferrari; Juana maria SAnz; VISHWANATH VENKETARAMAN; Olavio R Baricordi
Cytolytic P2X purinoceptors.
Cell death and differentiation 1998;5(3):191-9.
1997: Davide Ferrari; Paola Chiozzi; Simonetta Falzoni; M Dal Susino; G Collo; Gary N Buell; Francesco Di Virgilio
ATP-mediated cytotoxicity in microglial cells.
Neuropharmacology 1997;36(9):1295-301.
1997: Paola Chiozzi; Juana maria SAnz; Davide Ferrari; Simonetta Falzoni; Arrigo Aleotti; Gary N Buell; G Collo; Francesco Di Virgilio
Spontaneous cell fusion in macrophage cultures expressing high levels of the P2Z/P2X7 receptor.
The Journal of cell biology 1997;138(3):697-706.
1997: Davide Ferrari; Paola Chiozzi; Simonetta Falzoni; M Dal Susino; Loredana Melchiorri; Olavio R Baricordi; Francesco Di Virgilio
Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1451-8.
1997: Luis J V Galietta; Simonetta Falzoni; Francesco Di Virgilio; Giovanni Romeo; Olga Zegarra-Moran
Characterization of volume-sensitive taurine- and Cl(-)-permeable channels.
The American journal of physiology 1997;273(1 Pt 1):C57-66.
1997: D Ferrari; Paola Chiozzi; Simonetta Falzoni; Stefania Hanau; Francesco Di Virgilio
Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin.
The Journal of experimental medicine 1997;185(3):579-82.
1996: Marco Rossato; Francesco Di Virgilio; Carlo Foresta
Involvement of osmo-sensitive calcium influx in human sperm activation.
Molecular human reproduction 1996;2(12):903-9.
1996: Francesco Di Virgilio; C Mutini; Paola Chiozzi; Simonetta Falzoni; M Di Susino; Juana maria SAnz; Davide Ferrari
A purinergic hypothesis for immunomodulation.
The Italian journal of biochemistry 1996;45(4):195-203.
1996: Carlo Foresta; Marco Rossato; A Nogara; F Gottardello; P Bordon; Francesco Di Virgilio
Role of P2-purinergic receptors in rat Leydig cell steroidogenesis.
The Biochemical journal 1996;320 ( Pt 2)():499-504.
1996: Marco Rossato; P Bordon; Francesco Di Virgilio; Carlo Foresta
Capacitative calcium entry in rat Sertoli cells.
Journal of endocrinological investigation 1996;19(8):516-23.
1996: Anna Solini; Francesco Di Virgilio; Andrea Sfriso; Marino Bruseghin; Gaetano Crepaldi; Romano Nosadini
Intracellular calcium handling by fibroblasts from non-insulin dependent diabetic patients with and without hypertension and microalbuminuria.
Kidney international 1996;50(2):618-26.
1996: Carlo Foresta; Marco Rossato; Paola Chiozzi; Francesco Di Virgilio
Mechanism of human sperm activation by extracellular ATP.
The American journal of physiology 1996;270(6 Pt 1):C1709-14.
1996: Davide Ferrari; M Villalba; Paola Chiozzi; Simonetta Falzoni; Paola Ricciardi-Castagnoli; Francesco Di Virgilio
Mouse microglial cells express a plasma membrane pore gated by extracellular ATP.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(4):1531-9.
1996: Olavio R Baricordi; Davide Ferrari; Loredana Melchiorri; Paola Chiozzi; Stefania Hanau; E Chiari; Michele Rubini; Francesco Di Virgilio
An ATP-activated channel is involved in mitogenic stimulation of human T lymphocytes.
Blood 1996;87(2):682-90.
1996: Paola Chiozzi; Marta Murgia; Simonetta Falzoni; Davide Ferrari; Francesco Di Virgilio
Role of the purinergic P2Z receptor in spontaneous cell death in J774 macrophage cultures.
Biochemical and biophysical research communications 1996;218(1):176-81.
1996: Francesco Di Virgilio; Davide Ferrari; Simonetta Falzoni; Paola Chiozzi; M Munerati; T H Steinberg; Olavio R Baricordi
P2 purinoceptors in the immune system.
Ciba Foundation symposium 1996;198():290-302; discussion 302-5.
1995: Francesco Di Virgilio
The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death.
Immunology today 1995;16(11):524-8.
1995: M Villalba; D Ferrari; A Bozza; L Del Senno; Francesco Di Virgilio
Ionic regulation of endonuclease activity in PC12 cells.
The Biochemical journal 1995;311 ( Pt 3)():1033-8.
1995: Carlo Foresta; Marco Rossato; P Bordon; Francesco Di Virgilio
Extracellular ATP activates different signalling pathways in rat Sertoli cells.
The Biochemical journal 1995;311 ( Pt 1)():269-74.
1995: Simonetta Falzoni; M Munerati; Davide Ferrari; S Spisani; S Moretti; Francesco Di Virgilio
The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role.
The Journal of clinical investigation 1995;95(3):1207-16.
1995: Loredana Melchiorri; S Carturan; Davide Ferrari; Francesco Di Virgilio; Olavio R Baricordi
Increased sensitivity of DMD lymphoblastoid cell to low doses of X-irradiation.
Disease markers 1995;12(2):99-107.
1995: Carlo Foresta; Marco Rossato; Francesco Di Virgilio
Differential modulation by protein kinase C of progesterone-activated responses in human sperm.
Biochemical and biophysical research communications 1995;206(1):408-13.
1994: M Munerati; Rita Cortesi; Davide Ferrari; Francesco Di Virgilio; Claudio Nastruzzi
Macrophages loaded with doxorubicin by ATP-mediated permeabilization: potential carriers for antitumor therapy.
Biochimica et biophysica acta 1994;1224(2):269-76.
1994: Davide Ferrari; M Munerati; Loredana Melchiorri; Stefania Hanau; Francesco Di Virgilio; Olavio R Baricordi
Responses to extracellular ATP of lymphoblastoid cell lines from Duchenne muscular dystrophy patients.
The American journal of physiology 1994;267(4 Pt 1):C886-92.
1994: A Zambon; V Bronte; Francesco Di Virgilio; Stefania Hanau; T H Steinberg; D Collavo; Paola Zanovello
Role of extracellular ATP in cell-mediated cytotoxicity: a study with ATP-sensitive and ATP-resistant macrophages.
Cellular immunology 1994;156(2):458-67.
1993: V Bronte; Paola Zanovello; Antonio Rosato; A Zambon; S Mandruzzato; P Pizzo; Francesco Di Virgilio; D Collavo
Synergistic effect of extracellular adenosine 5'-triphosphate and tumor necrosis factor on DNA degradation.
Cellular immunology 1993;152(1):110-9.
1993: Carlo Foresta; Marco Rossato; Francesco Di Virgilio
Ion fluxes through the progesterone-activated channel of the sperm plasma membrane.
The Biochemical journal 1993;294 ( Pt 1)():279-83.
1993: Marta Murgia; Stefania Hanau; Paola Pizzo; M Rippa; Francesco Di Virgilio
Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor.
The Journal of biological chemistry 1993;268(11):8199-203.
1992: Marta Murgia; Paola Pizzo; T H Steinberg; Francesco Di Virgilio
Characterization of the cytotoxic effect of extracellular ATP in J774 mouse macrophages.
The Biochemical journal 1992;288 ( Pt 3)():897-901.
1992: Paola Pizzo; Marta Murgia; A Zambon; Paola Zanovello; V Bronte; Daniela Pietrobon; Francesco Di Virgilio
Role of P2z purinergic receptors in ATP-mediated killing of tumor necrosis factor (TNF)-sensitive and TNF-resistant L929 fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3372-8.
1992: Carlo Foresta; Marco Rossato; Francesco Di Virgilio
Extracellular ATP is a trigger for the acrosome reaction in human spermatozoa.
The Journal of biological chemistry 1992;267(27):19443-7.
1992: Marta Murgia; P Pizzo; D Sandoná; Paola Zanovello; Rosario Rizzuto; Francesco Di Virgilio
Mitochondrial DNA is not fragmented during apoptosis.
The Journal of biological chemistry 1992;267(16):10939-41.
1991: F Michelangeli; Francesco Di Virgilio; A Villa; P Podini; Jacopo Meldolesi; Tullio Pozzan
Identification, kinetic properties and intracellular localization of the (Ca(2+)-Mg2+)-ATPase from the intracellular stores of chicken cerebellum.
The Biochemical journal 1991;275 ( Pt 3)():555-61.
1991: Paola Pizzo; Paola Zanovello; V Bronte; Francesco Di Virgilio
Extracellular ATP causes lysis of mouse thymocytes and activates a plasma membrane ion channel.
The Biochemical journal 1991;274 ( Pt 1)():139-44.
1990: Daniela Pietrobon; Francesco Di Virgilio; T Pozzan
Structural and functional aspects of calcium homeostasis in eukaryotic cells.
European journal of biochemistry / FEBS 1990;193(3):599-622.
1990: Paola Zanovello; V Bronte; Antonio Rosato; P Pizzo; Francesco Di Virgilio
Responses of mouse lymphocytes to extracellular ATP. II. Extracellular ATP causes cell type-dependent lysis and DNA fragmentation.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(5):1545-50.
1990: Francesco Di Virgilio; P Pizzo; Paola Zanovello; V Bronte; D Collavo
Extracellular ATP as a possible mediator of cell-mediated cytotoxicity.
Immunology today 1990;11(8):274-7.
1990: Francesco Di Virgilio; T H Steinberg; Samuel C. Silverstein
Inhibition of Fura-2 sequestration and secretion with organic anion transport blockers.
Cell calcium 1990;11(2-3):57-62.
1989: Francesco Di Virgilio; V Bronte; D Collavo; Paola Zanovello
Responses of mouse lymphocytes to extracellular adenosine 5'-triphosphate (ATP). Lymphocytes with cytotoxic activity are resistant to the permeabilizing effects of ATP.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(6):1955-60.
1989: Paola Zanovello; Antonio Rosato; V Bronte; V Cerundolo; S Treves; Francesco Di Virgilio; T Pozzan; Giovanni Biasi; D Collavo
Interaction of lymphokine-activated killer cells with susceptible targets does not induce second messenger generation and cytolytic granule exocytosis.
The Journal of experimental medicine 1989;170(3):665-77.
1989: Francesco Di Virgilio; T H Steinberg; Samuel C. Silverstein
Organic-anion transport inhibitors to facilitate measurement of cytosolic free Ca2+ with fura-2.
Methods in cell biology 1989;31():453-62.
1987: S Treves; Francesco Di Virgilio; V Cerundolo; Paola Zanovello; D Collavo; T Pozzan
Calcium and inositolphosphates in the activation of T cell-mediated cytotoxicity.
The Journal of experimental medicine 1987;166(1):33-42.