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Suresh Ambudkar

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Karthika Natarajan; Suneet Shukla; Suresh V Ambudkar; Jasjeet Bhullar; Mehmet Burcu; Zhe-Sheng Chen; Maria R Baer
The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms.
Damien Y Duveau; Xin Hu; Min Shen; Suneet Shukla; Amanda P Skoumbourdis; Suresh V Ambudkar; Matthew B Boxer; Martin J Walsh; Craig J Thomas
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.
Marianne T Downes; Suresh V Ambudkar; Neeti Ananthaswamy; Elliot Dine; Micheala Lamonde; Jitender Mehla; Adina Wakschlag; John Golin
The transmission interface of the Saccharomyces cerevisiae multidrug transporter Pdr5: Val-656 located in intracellular loop 2 plays a major role in drug resistance.

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2013: Karthika Natarajan; Suneet Shukla; Suresh V Ambudkar; Jasjeet Bhullar; Mehmet Burcu; Zhe-Sheng Chen; Maria R Baer
The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms.
Biochemical pharmacology 2013;85(4):514-24.
2013: Damien Y Duveau; Xin Hu; Min Shen; Suneet Shukla; Amanda P Skoumbourdis; Suresh V Ambudkar; Matthew B Boxer; Martin J Walsh; Craig J Thomas
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.
Bioorganic & medicinal chemistry letters 2013;23(3):682-6.
2013: Marianne T Downes; Suresh V Ambudkar; Neeti Ananthaswamy; Elliot Dine; Micheala Lamonde; Jitender Mehla; Adina Wakschlag; John Golin
The transmission interface of the Saccharomyces cerevisiae multidrug transporter Pdr5: Val-656 located in intracellular loop 2 plays a major role in drug resistance.
Antimicrobial agents and chemotherapy 2013;57(2):1025-34.
2013: Chung-Pu Wu; Suresh V Ambudkar; Hsing-Wen Cheng; Sung-Han Hsiao; Yang-Hui Huang; Yan-Qing Li; Yen-Chen Liu; Hong-May Sim; Sheng-Chieh Hsu
Overexpression of ATP-binding cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cells.
Biochemical pharmacology 2013;85(3):325-34.
2013: Megan R Ansbro; Suneet Shukla; Stuart H Yuspa; Suresh V Ambudkar; Luowei Li
Screening Compounds with a Novel High-Throughput ABCB1-Mediated Efflux Assay Identifies Drugs with Known Therapeutic Targets at Risk for Multidrug Resistance Interference.
PloS one 2013;8(4):e60334.
2013: Ke-Jun Liu; Hong-May Sim; Satyakam Singh; Kamlesh Sodani; Xiao-Dong Su; TT Talele; Fang Wang; Hai-Ying Wu; Jing-Dun Xie; Suresh V Ambudkar; Xing-Gui Chen; Zhe-Sheng Chen; Jie-Hua He; Yong-Ju Liang; Li-Wu Fu
Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo.
International journal of cancer. Journal international du cancer 2013;132(1):224-35.
2012: Dong-Mei Zhang; Suresh V Ambudkar; Jaya Bhatnagar; Jun-Jiang Chen; Wei-Min Chen; Zhe-Sheng Chen; Ping Lan; Zhi-Xiong Ruan; Chang Shu; Kamlesh Sodani; Jiao Wang; Zhi-Jie Xiao; Wen-Cai Ye
BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo.
Molecular pharmaceutics 2012;9(11):3147-59.
2012: Vineet Gupta; Ming-Yi Ho; Salman B Hosain; S Michal Jazwinski; Kay-Hooi Khoo; Su-Chen Li; Yu-Teh Li; Suresh V Ambudkar; Kaustubh N Bhinge; Xin Gu; Runhua Shi; Katherine Xiong; Yong-Yu Liu
Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells.
The Journal of biological chemistry 2012;287(44):37195-205.
2012: Ye-Hong Kuang; Li-Qiu Liao; Atish Patel; Jay P Patel; Kamlesh Sodani; Amit K Tiwari; Chung-Pu Wu; Suresh V Ambudkar; Xiang Chen; Chun-Ling Dai; Li-Wu Fu; Vijaya L Korlipara; Zhe-Sheng Chen
OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance.
Biochemical pharmacology 2012;84(6):766-74.
2012: Rupashree Sen; Suneet Shukla; Suresh V Ambudkar; Jasjeet Bhullar; Ling Cai; Zhe-Sheng Chen; Hongbin Fang; Karthika Natarajan; Maria R Baer
The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2.
Molecular cancer therapeutics 2012;11(9):2033-44.
2012: Xiao-qin Zhao; Suresh V Ambudkar; Xing-gui Chen; Zhe-Sheng Chen; Yong-Ju Liang; Hong May Sim; Satyakam Singh; Yueli Sun; Tanaji T Talele; Jing-dun Xie; Xu Zhang; Li-Wu Fu
Neratinib reverses ATP-binding cassette B1-mediated chemotherapeutic drug resistance in vitro, in vivo, and ex vivo.
Molecular pharmacology 2012;82(1):47-58.
2012: Jean-Pierre Gillet; Suresh V Ambudkar; Mari Bunkholt Elstrand; Anna Maria Calcagno; Ben Davidson; Ram Ganapathi; Aparna A Kamat; Bo R Rueda; Michael Seiden; Anil K Sood; Sudhir Varma; Michael M Gottesman
Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(11):3197-206.
2012: Suneet Shukla; Zhe-Sheng Chen; Suresh V Ambudkar
Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2012;15(1-2):70-80.
2012: Suneet Shukla; Khyati Kapoor; Abdul Kouanda; Candice Schwartz; Suresh V Ambudkar
Use of baculovirus BacMam vectors for expression of ABC drug transporters in mammalian cells.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(2):304-12.
2011: Jean-Pierre Gillet; Suresh V Ambudkar; Mari Bunkholt Elstrand; Anna Maria Calcagno; Ben Davidson; Lisa J Green; Claes G Trope; Sudhir Varma; Junbai Wang; Michael M Gottesman
Clinical relevance of multidrug resistance gene expression in ovarian serous carcinoma effusions.
Molecular pharmaceutics 2011;8(6):2080-8.
2011: Hong-May Sim; Chung-Pu Wu; Suresh V Ambudkar; Mei-Lin Go
In vitro and in vivo modulation of ABCG2 by functionalized aurones and structurally related analogs.
Biochemical pharmacology 2011;82(11):1562-71.
2011: Jean-Pierre Gillet; Suresh V Ambudkar; Anna Maria Calcagno; Ben Davidson; Tatiana A Eliseeva; Ram Ganapathi; Lisa J Green; Miguel Marino; Josiah N Orina; Raji Padmanabhan; Chirayu Patel; Bo R Rueda; Vineet Singal; Anil K Sood; Sudhir Varma; Meena I Vora; Michael M Gottesman
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(46):18708-13.
2011: Suneet Shukla; Amanda P Skoumbourdis; Craig J Thomas; Martin J Walsh; Chung-Pu Wu; Björn Bauer; King-Leung Fung; Michael M Gottesman; Anika M S Hartz; Suresh V Ambudkar
Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters.
Molecular pharmaceutics 2011;8(4):1292-302.
2011: Shinobu Ohnuma; Eduardo Chufan; Krishnamachary Nandigama; Lisa M Miller Jenkins; Stewart R Durell; Ettore Appella; Zuben Sauna; Suresh V Ambudkar
Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites.
Biochemistry 2011;50(18):3724-35.
2011: S Shukla; S Ohnuma; Suresh V Ambudkar
Improving cancer chemotherapy with modulators of ABC drug transporters.
Current drug targets 2011;12(5):621-30.
2011: Zhi Shi; Amit K. Tiwari; Suneet Shukla; Robert W Robey; Satyakam Singh; In-Wha Kim; Susan E Bates; Xingxiang Peng; Ioana Abraham; Suresh V Ambudkar; TT Talele; Li-Wu Fu; Zhe-Sheng Chen
Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.
Cancer research 2011;71(8):3029-41.
2011: Chung-Pu Wu; Shinobu Ohnuma; Suresh V Ambudkar
Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy.
Current pharmaceutical biotechnology 2011;12(4):609-20.
2011: Pavitra Kannan; Victor W Pike; Suneet Shukla; Sanjay Telu; Suresh V Ambudkar; Michael M Gottesman; Christer Halldin; Robert B Innis; Matthew D Hall
The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2).
ACS chemical neuroscience 2011;2(2):82-9.
2011: Pei-Rong Ding; Amit K. Tiwari; Shinobu Ohnuma; Jeferson W K K Lee; Xin An; Chun-Ling Dai; Qi-Si Lu; Satyakam Singh; Dong-Hua Yang; TT Talele; Suresh V Ambudkar; Zhe-Sheng Chen
The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter.
PloS one 2011;6(4):e19329.
2010: Ioana Abraham; Sandeep Jain; Chung-Pu Wu; Mohammad A Khanfar; Yehong Kuang; Chun-Ling Dai; Zhi Shi; Xiang Chen; Liwu Fu; Suresh V Ambudkar; Khalid El Sayed; Zhe-Sheng Chen
Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.
Biochemical pharmacology 2010;80(10):1497-506.
2010: Anna Maria Calcagno; Crystal D Salcido; Jean-Pierre Gillet; Chung-Pu Wu; Jennifer Fostel; Melanie D Mumau; Michael M Gottesman; Lyuba Varticovski; Suresh V Ambudkar
Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics.
Journal of the National Cancer Institute 2010;102(21):1637-52.
2010: Yan-Jun Mi; Yong-Ju Liang; Hong-Bing Huang; Hong-Yun Zhao; Chung-Pu Wu; Fang Wang; Li-Yang Tao; Chuan-Zhao Zhang; Chun-Ling Dai; Amit K. Tiwari; Xiao-Xu Ma; Kenneth Kin Wah To; Suresh V Ambudkar; Zhe-Sheng Chen; Li-Wu Fu
Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters.
Cancer research 2010;70(20):7981-91.
2010: Antresh Kumar; Suneet Shukla; Ajeet Mandal; Suneet Shukla; Suresh V Ambudkar; Rajendra Prasad
Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable.
Biochimica et biophysica acta 2010;1798(9):1757-66.
2010: Joseph Tam; V Kiran Vemuri; Jie Liu; Sándor Bátkai; Bani Mukhopadhyay; Grzegorz Godlewski; Douglas Osei-Hyiaman; Shinobu Ohnuma; Suresh V Ambudkar; James Pickel; Alexandros Makriyannis; George Kunos
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity.
The Journal of clinical investigation 2010;120(8):2953-66.
2010: Marius Dohse; Christian Scharenberg; Suneet Shukla; Robert W Robey; Thorsten Volkmann; John F Deeken; Cornelia Brendel; Suresh V Ambudkar; Andreas Neubauer; Susan E Bates
Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(8):1371-80.
2010: Luowei Li; Suneet Shukla; Andrew Lee; Susan H Garfield; David J Maloney; Suresh V Ambudkar; Stuart H Yuspa
The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.
Cancer research 2010;70(11):4509-19.
2010: Neeti Ananthaswamy; Robert Rutledge; Zuben Sauna; Suresh V Ambudkar; Elliot Dine; Emily Nelson; Di Xia; John Golin
The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.
Biochemistry 2010;49(21):4440-9.
2010: Marek Kucka; Karla Kretschmannova; Takayo Murano; Chung-Pu Wu; Hana Zemkova; Suresh V Ambudkar; Stanko S Stojilkovic
Dependence of multidrug resistance protein-mediated cyclic nucleotide efflux on the background sodium conductance.
Molecular pharmacology 2010;77(2):270-9.
2010: Anna Maria Calcagno; Suresh V Ambudkar
Analysis of expression of drug resistance-linked ABC transporters in cancer cells by quantitative RT-PCR.
Methods in molecular biology (Clifton, N.J.) 2010;637():121-32.
2010: Anna Maria Calcagno; Suresh V Ambudkar
Molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells.
Methods in molecular biology (Clifton, N.J.) 2010;596():77-93.
2009: John F Deeken; Robert W Robey; Suneet Shukla; Kenneth Steadman; Arup R Chakraborty; Balasubramanian Poonkuzhali; Erin G Schuetz; Susan Holbeck; Suresh V Ambudkar; Susan E Bates
Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen.
Molecular pharmacology 2009;76(5):946-56.
2009: Nidhi Puri; Manisha Gaur; Monika Sharma; Suneet Shukla; Suresh V Ambudkar; Rajendra Prasad
The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport.
Biochimica et biophysica acta 2009;1788(9):1752-61.
2009: Curtis J Henrich; Robert W Robey; Kentaro Takada; Heidi R Bokesch; Susan E Bates; Suneet Shukla; Suresh V Ambudkar; James B McMahon; Kirk R Gustafson
Botryllamides: natural product inhibitors of ABCG2.
ACS chemical biology 2009;4(8):637-47.
2009: Chun-ling Dai; Yong-ju Liang; Li-ming Chen; Xu Zhang; Wen-jing Deng; Xiao-dong Su; Zhi Shi; Chung-Pu Wu; Charles R Ashby; Shin-ichi Akiyama; Suresh V Ambudkar; Zhe-Sheng Chen; Li-Wu Fu
Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function.
Biochemical pharmacology 2009;78(4):355-64.
2009: Monika Sharma; Raman Manoharlal; Suneet Shukla; Nidhi Puri; Tulika Prasad; Suresh V Ambudkar; Rajendra Prasad
Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals.
Antimicrobial agents and chemotherapy 2009;53(8):3256-65.
2009: Robert W Robey; Tomasz Obrzut; Suneet Shukla; Orsolya Polgar; Sira Macalou; Julian C Bahr; Attilio Di Pietro; Suresh V Ambudkar; Susan E Bates
Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells.
Cancer chemotherapy and pharmacology 2009;64(3):575-83.
2009: Josiah N Orina; Anna Maria Calcagno; Chung-Pu Wu; Sudhir Varma; Joanna Shih; Min Lin; Gabriel Eichler; John N Weinstein; Yves Pommier; Suresh V Ambudkar; Michael M Gottesman; Jean-Pierre Gillet
Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database.
Molecular cancer therapeutics 2009;8(7):2057-66.
2009: Michael M Gottesman; Suresh V Ambudkar; Di Xia
Structure of a multidrug transporter.
Nature biotechnology 2009;27(6):546-7.
2009: Zhi Shi; Amit K. Tiwari; Suneet Shukla; Robert W Robey; In-Wha Kim; Smitaben Parmar; Susan E Bates; Qiu-Sheng Si; Curtis S Goldblatt; Ioana Abraham; Li-Wu Fu; Suresh V Ambudkar; Zhe-Sheng Chen
Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478.
Biochemical pharmacology 2009;77(5):781-93.
2009: Suneet Shukla; Robert W Robey; Susan E Bates; Suresh V Ambudkar
Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):359-65.
2009: Suneet Shukla; H Zaher; Anika Hartz; Björn Bauer; Joseph A Ware; Suresh V Ambudkar
Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice.
Pharmaceutical research 2009;26(2):480-7.
2009: Ryan Hunt; Zuben E Sauna; Suresh V Ambudkar; Michael M Gottesman; Chava Kimchi-Sarfaty
Silent (synonymous) SNPs: should we care about them?
Methods in molecular biology (Clifton, N.J.) 2009;578():23-39.
2008: Zuben Sauna; Sherry Supernavage Bohn; Robert Rutledge; Michael P Dougherty; Susan Cronin; Leopold May; Di Xia; Suresh V Ambudkar; John Golin
Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport.
The Journal of biological chemistry 2008;283(50):35010-22.
2008: Erin R Gardner; Christoph M Ahlers; Suneet Shukla; Tristan Sissung; Sandra B Ockers; Douglas K Price; Akinobu Hamada; Robert W Robey; Seth M Steinberg; Suresh V Ambudkar; William L Dahut; William D Figg
Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival.
BJU international 2008;102(11):1694-9.
2008: Chung-Jung Tsai; Zuben E Sauna; Chava Kimchi-Sarfaty; Suresh V Ambudkar; Michael M Gottesman; Ruth Nussinov
Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.
Journal of molecular biology 2008;383(2):281-91.
2008: Chun-ling Dai; Amit K. Tiwari; Chung-Pu Wu; Xiao-Dong Su; Si-Rong Wang; Dong-Geng Liu; Charles R Ashby; Yan Huang; Robert W Robey; Yong-ju Liang; Li-ming Chen; Cheng-Jun Shi; Suresh V Ambudkar; Zhe-Sheng Chen; Li-Wu Fu
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.
Cancer research 2008;68(19):7905-14.
2008: Shih-Yin Chen; Chi-Jiunn Pan; Krishnamachary Nandigama; Brian C Mansfield; Suresh V Ambudkar; Janice Yang Chou
The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2206-13.
2008: Chung-Pu Wu; Anna Maria Calcagno; Suresh V Ambudkar
Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies.
Current molecular pharmacology 2008;1(2):93-105.
2008: Anna Maria Calcagno; Jennifer Fostel; K K W To; C D Salcido; S E Martin; K J Chewning; Chung-Pu Wu; Lyuba Varticovski; Susan E Bates; Natasha J Caplen; Suresh V Ambudkar
Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes.
British journal of cancer 2008;98(9):1515-24.
2008: Robert W Robey; Suneet Shukla; Elizabeth M Finley; Robert K Oldham; Daryl Barnett; Suresh V Ambudkar; Tito Fojo; Susan E Bates
Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).
Biochemical pharmacology 2008;75(6):1302-12.
2008: In-Wha Kim; Catherine Booth-Genthe; Suresh V Ambudkar
Relationship between drugs and functional activity of various mammalian P-glycoproteins (ABCB1).
Mini reviews in medicinal chemistry 2008;8(3):193-200.
2008: Suneet Shukla; Chung-Pu Wu; Suresh V Ambudkar
Development of inhibitors of ATP-binding cassette drug transporters: present status and challenges.
Expert opinion on drug metabolism & toxicology 2008;4(2):205-23.
2008: Mollie H Wright; Anna Maria Calcagno; Crystal D Salcido; Marisa D Carlson; Suresh V Ambudkar; Lyuba Varticovski
Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics.
Breast cancer research : BCR 2008;10(1):R10.
2007: Zuben Sauna; In-Wha Kim; Krishnamachary Nandigama; Stephan Kopp; Peter Chiba; Suresh V Ambudkar
Catalytic cycle of ATP hydrolysis by P-glycoprotein: evidence for formation of the E.S reaction intermediate with ATP-gamma-S, a nonhydrolyzable analogue of ATP.
Biochemistry 2007;46(48):13787-99.
2007: Chung-Pu Wu; Suneet Shukla; Anna Maria Calcagno; Matthew D Hall; Michael M Gottesman; Suresh V Ambudkar
Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter.
Molecular cancer therapeutics 2007;6(12 Pt 1):3287-96.
2007: Curtis J Henrich; Robert W Robey; Heidi R Bokesch; Susan E Bates; Suneet Shukla; Suresh V Ambudkar; Michael Dean; James B McMahon
New inhibitors of ABCG2 identified by high-throughput screening.
Molecular cancer therapeutics 2007;6(12 Pt 1):3271-8.
2007: Suneet Shukla; Chung-Pu Wu; Krishnamachary Nandigama; Suresh V Ambudkar
The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2.
Molecular cancer therapeutics 2007;6(12 Pt 1):3279-86.
2007: Zuben Sauna; In-Wha Kim; Suresh V Ambudkar
Genomics and the mechanism of P-glycoprotein (ABCB1).
Journal of bioenergetics and biomembranes 2007;39(5-6):481-7.
2007: Zhi Shi; Xing-Xiang Peng; In-Wha Kim; Suneet Shukla; Qiu-Sheng Si; Robert W Robey; Susan E Bates; Tong Shen; Charles R Ashby; Li-Wu Fu; Suresh V Ambudkar; Zhe-Sheng Chen
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance.
Cancer research 2007;67(22):11012-20.
2007: John Golin; Zachary N Kon; Chung-Pu Wu; Justin Martello; Leanne Hanson; Sherry Supernavage; Suresh V Ambudkar; Zuben Sauna
Complete inhibition of the Pdr5p multidrug efflux pump ATPase activity by its transport substrate clotrimazole suggests that GTP as well as ATP may be used as an energy source.
Biochemistry 2007;46(45):13109-19.
2007: Zuben Sauna; Chava Kimchi-Sarfaty; Suresh V Ambudkar; Michael M Gottesman
Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer.
Cancer research 2007;67(20):9609-12.
2007: Anna Maria Calcagno; In-Wha Kim; Chung-Pu Wu; Suneet Shukla; Suresh V Ambudkar
ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions.
Current drug delivery 2007;4(4):324-33.
2007: Zhi Shi; Sandeep Jain; In-Wha Kim; Xing-Xiang Peng; Ioana Abraham; Diaa T A Youssef; Li-Wu Fu; Khalid A El-Sayed; Suresh V Ambudkar; Zhe-Sheng Chen
Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.
Cancer science 2007;98(9):1373-80.
2007: Jill K Paterson; Suneet Shukla; Chelsea M Black; Tokushi Tachiwada; Susan H Garfield; Stephen Wincovitch; David N Ernst; Anissa Agadir; Xuelin Li; Suresh V Ambudkar; Gergely Szakacs; Shin-ichi Akiyama; Michael M Gottesman
Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane.
Biochemistry 2007;46(33):9443-52.
2007: Attaphol Pawarode; Suneet Shukla; Hans Minderman; Stacy M Fricke; Elaine M Pinder; Kieran L O'Loughlin; Suresh V Ambudkar; Maria R Baer
Differential effects of the immunosuppressive agents cyclosporin A, tacrolimus and sirolimus on drug transport by multidrug resistance proteins.
Cancer chemotherapy and pharmacology 2007;60(2):179-88.
2007: Robert W Robey; Suneet Shukla; Kenneth Steadman; Tomasz Obrzut; Elizabeth M Finley; Suresh V Ambudkar; Susan E Bates
Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure.
Molecular cancer therapeutics 2007;6(6):1877-85.
2007: Zuben Sauna; Chava Kimchi-Sarfaty; Suresh V Ambudkar; Michael M Gottesman
The sounds of silence: synonymous mutations affect function.
Pharmacogenomics 2007;8(6):527-32.
2007: John Golin; Suresh V Ambudkar; Leopold May
The yeast Pdr5p multidrug transporter: how does it recognize so many substrates?
Biochemical and biophysical research communications 2007;356(1):1-5.
2007: Pornngarm Limtrakul; Wanida Chearwae; Suneet Shukla; Chada Phisalphong; Suresh V Ambudkar
Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin.
Molecular and cellular biochemistry 2007;296(1-2):85-95.
2007: Chava Kimchi-Sarfaty; Jung Mi Oh; In-Wha Kim; Zuben Sauna; Anna Maria Calcagno; Suresh V Ambudkar; Michael M Gottesman
A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Science (New York, N.Y.) 2007;315(5811):525-8.
2007: Zuben Sauna; Suresh V Ambudkar
About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work.
Molecular cancer therapeutics 2007;6(1):13-23.
2006: Versha Rai; Manisha Gaur; Suneet Shukla; Suneet Shukla; Suresh V Ambudkar; Sneha Sudha Komath; Rajendra Prasad
Conserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysis.
Biochemistry 2006;45(49):14726-39.
2006: Jennifer A Seamon; Catherine A Rugg; Stuart Emanuel; Anna Maria Calcagno; Suresh V Ambudkar; Steven A Middleton; Jeannene Butler; Virna Borowski; Lee M Greenberger
Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor.
Molecular cancer therapeutics 2006;5(10):2459-67.
2006: Zuben Sauna; Krishnamachary Nandigama; Suresh V Ambudkar
Exploiting reaction intermediates of the ATPase reaction to elucidate the mechanism of transport by P-glycoprotein (ABCB1).
The Journal of biological chemistry 2006;281(36):26501-11.
2006: Wanida Chearwae; Suneet Shukla; Pornngarm Limtrakul; Suresh V Ambudkar
Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin.
Molecular cancer therapeutics 2006;5(8):1995-2006.
2006: Suneet Shukla; Robert W Robey; Susan E Bates; Suresh V Ambudkar
The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.
Biochemistry 2006;45(29):8940-51.
2006: In-Wha Kim; Xiang-Hong Peng; Zuben Sauna; Peter C FitzGerald; Di Xia; Marianna Müller; Krishnamachary Nandigama; Suresh V Ambudkar
The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette.
Biochemistry 2006;45(24):7605-16.
2006: Joseph A Ludwig; Gergely Szakács; Scott E Martin; Benjamin F Chu; Carol Cardarelli; Zuben Sauna; Natasha J Caplen; Henry M Fales; Suresh V Ambudkar; John N Weinstein; Michael M Gottesman
Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.
Cancer research 2006;66(9):4808-15.
2006: Suresh V Ambudkar; In-Wha Kim; Zuben Sauna
The power of the pump: mechanisms of action of P-glycoprotein (ABCB1).
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;27(5):392-400.
2006: Suresh V Ambudkar; In-Wha Kim; Di Xia; Zuben Sauna
The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding.
FEBS letters 2006;580(4):1049-55.
2006: Wanida Chearwae; Chung-Pu Wu; H-Y Chu; T Randall Lee; Suresh V Ambudkar; Pornngarm Limtrakul
Curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (ABCC1).
Cancer chemotherapy and pharmacology 2006;57(3):376-88.
2006: Anna Maria Calcagno; Katherine J Chewning; Chung-Pu Wu; Suresh V Ambudkar
Plasma membrane calcium ATPase (PMCA4): a housekeeper for RT-PCR relative quantification of polytopic membrane proteins.
BMC molecular biology 2006;7():29.
2006: Anna Maria Calcagno; Joseph A Ludwig; Jennifer Fostel; Michael M Gottesman; Suresh V Ambudkar
Comparison of drug transporter levels in normal colon, colon cancer, and Caco-2 cells: impact on drug disposition and discovery.
Molecular pharmaceutics 2006;3(1):87-93.
2005: Chung-Pu Wu; Anna Maria Calcagno; Stephen B Hladky; Suresh V Ambudkar; Margery A Barrand
Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).
The FEBS journal 2005;272(18):4725-40.
2005: Chung-Pu Wu; Antonios Klokouzas; Stephen B Hladky; Suresh V Ambudkar; Margery A Barrand
Interactions of mefloquine with ABC proteins, MRP1 (ABCC1) and MRP4 (ABCC4) that are present in human red cell membranes.
Biochemical pharmacology 2005;70(4):500-10.
2005: Suresh V Ambudkar; Zuben Sauna; Michael M Gottesman; Gergely Szakacs
A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1).
Trends in pharmacological sciences 2005;26(8):385-7.
2005: Leanne Hanson; Leopold May; Pamela Tuma; James Keeven; Patrick Mehl; Michelle Ferenz; Suresh V Ambudkar; John Golin
The role of hydrogen bond acceptor groups in the interaction of substrates with Pdr5p, a major yeast drug transporter.
Biochemistry 2005;44(28):9703-13.
2005: Zuben Sauna; Suneet Shukla; Suresh V Ambudkar
Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections.
Molecular bioSystems 2005;1(2):127-34.
2005: Yong Jiang; Hiranmoy Bhattacharjee; Tongqing Zhou; Barry P Rosen; Suresh V Ambudkar; Zuben Sauna
Nonequivalence of the nucleotide binding domains of the ArsA ATPase.
The Journal of biological chemistry 2005;280(11):9921-6.
2004: Zuben Sauna; Krishnamachary Nandigama; Suresh V Ambudkar
Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state.
The Journal of biological chemistry 2004;279(47):48855-64.
2004: Wanida Chearwae; Songyot Anuchapreeda; Krishnamachary Nandigama; Suresh V Ambudkar; Pornngarm Limtrakul
Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.
Biochemical pharmacology 2004;68(10):2043-52.
2004: Suneet Shukla; Zuben Sauna; Rajendra Prasad; Suresh V Ambudkar
Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans.
Biochemical and biophysical research communications 2004;322(2):520-5.
2004: Brij B Singh; Timothy P Lockwich; Bidhan Bandyopadhyay; Xibao Liu; Sunitha Bollimuntha; So-Ching Brazer; Christian Combs; Sunit Das; Miriam Leenders; Zu-Hang Sheng; Mark A Knepper; Suresh V Ambudkar; Indu S Ambudkar
VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels and contributes to agonist-stimulated Ca2+ influx.
Molecular cell 2004;15(4):635-46.
2004: Orsolya Polgar; Robert W Robey; Kuniaki Morisaki; Michael Dean; Christopher Michejda; Zuben Sauna; Suresh V Ambudkar; Nadya Tarasova; Susan E Bates
Mutational analysis of ABCG2: role of the GXXXG motif.
Biochemistry 2004;43(29):9448-56.
2004: Suneet Shukla; Suresh V Ambudkar; Rajendra Prasad
Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520.
The Journal of antimicrobial chemotherapy 2004;54(1):38-45.
2004: Zuben Sauna; Merritt B Andrus; Timothy M. Turner; Suresh V Ambudkar
Biochemical basis of polyvalency as a strategy for enhancing the efficacy of P-glycoprotein (ABCB1) modulators: stipiamide homodimers separated with defined-length spacers reverse drug efflux with greater efficacy.
Biochemistry 2004;43(8):2262-71.
2004: Zuben Sauna; Xiang-Hong Peng; Krishnamachary Nandigama; Samrawit Tekle; Suresh V Ambudkar
The molecular basis of the action of disulfiram as a modulator of the multidrug resistance-linked ATP binding cassette transporters MDR1 (ABCB1) and MRP1 (ABCC1).
Molecular pharmacology 2004;65(3):675-84.
2003: Suneet Shukla; Preeti Saini; Sudhakar Jha; Suresh V Ambudkar; Rajendra Prasad
Functional characterization of Candida albicans ABC transporter Cdr1p.
Eukaryotic cell 2003;2(6):1361-75.
2003: Suresh V Ambudkar; Chava Kimchi-Sarfaty; Zuben Sauna; Michael M Gottesman
P-glycoprotein: from genomics to mechanism.
Oncogene 2003;22(47):7468-85.
2003: John Golin; Suresh V Ambudkar; Michael M Gottesman; Asif Dominic Habib; John Sczepanski; William Ziccardi; Leopold May
Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux.
The Journal of biological chemistry 2003;278(8):5963-9.
2002: Zuben Sauna; Marianna Müller; Xiang-Hong Peng; Suresh V Ambudkar
Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1).
Biochemistry 2002;41(47):13989-4000.
2002: Hannah Rahamimoff; Xiaoyan Ren; Chava Kimchi-Sarfaty; Suresh V Ambudkar; Judith Kasir
NCX1 surface expression: a tool to identify structural elements of functional importance.
Annals of the New York Academy of Sciences 2002;976():176-86.
2002: Libor Kozak; Ganesh Gopal; Jin Ho Yoon; Zuben Sauna; Suresh V Ambudkar; Anjan G Thakurta; Ravi Dhar
Elf1p, a member of the ABC class of ATPases, functions as a mRNA export factor in Schizosacchromyces pombe.
The Journal of biological chemistry 2002;277(37):33580-9.
2002: Songyot Anuchapreeda; Pranee Leechanachai; Melissa M Smith; Suresh V Ambudkar; Pornngarm Limtrakul
Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells.
Biochemical pharmacology 2002;64(4):573-82.
2002: Marianna Müller; Michelle Yong; Xiang-Hong Peng; Ben Petre; Sonia Arora; Suresh V Ambudkar
Evidence for the role of glycosylation in accessibility of the extracellular domains of human MRP1 (ABCC1).
Biochemistry 2002;41(31):10123-32.
2002: Chava Kimchi-Sarfaty; Judith Kasir; Suresh V Ambudkar; Hannah Rahamimoff
Transport activity and surface expression of the Na+-Ca2+ exchanger NCX1 are inhibited by the immunosuppressive agent cyclosporin A and by the nonimmunosuppressive agent PSC833.
The Journal of biological chemistry 2002;277(4):2505-10.
2001: Zuben Sauna; MM Smith; M Müller; K M Kerr; Suresh V Ambudkar
The mechanism of action of multidrug-resistance-linked P-glycoprotein.
Journal of bioenergetics and biomembranes 2001;33(6):481-91.
2001: Michael M Gottesman; Suresh V Ambudkar
Overview: ABC transporters and human disease.
Journal of bioenergetics and biomembranes 2001;33(6):453-8.
2001: Zuben Sauna; MM Smith; Marianna Müller; Suresh V Ambudkar
Evidence for the vectorial nature of drug (substrate)-stimulated ATP hydrolysis by human P-glycoprotein.
The Journal of biological chemistry 2001;276(36):33301-4.
2001: Zuben Sauna; MM Smith; M Muller; Suresh V Ambudkar
Functionally similar vanadate-induced 8-azidoadenosine 5'-[alpha-(32)P]Diphosphate-trapped transition state intermediates of human P-glycoprotin are generated in the absence and presence of ATP hydrolysis.
The Journal of biological chemistry 2001;276(24):21199-208.
2001: Zuben Sauna; Suresh V Ambudkar
Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes.
The Journal of biological chemistry 2001;276(15):11653-61.
2001: K M Kerr; Zuben Sauna; Suresh V Ambudkar
Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates.
The Journal of biological chemistry 2001;276(12):8657-64.
2000: Merritt B Andrus; Timothy M. Turner; Zuben Sauna; Suresh V Ambudkar
Synthesis and preliminary analysis of a P-glycoprotein-specific [3H]-benzophenone photoaffinity label based on (-)-stipiamide.
Bioorganic & medicinal chemistry letters 2000;10(20):2275-8.
2000: Merritt B Andrus; Timothy M. Turner; Zuben Sauna; Suresh V Ambudkar
The synthesis and evaluation of a solution phase indexed combinatorial library of non-natural polyenes for reversal of P-glycoprotein mediated multidrug resistance.
The Journal of organic chemistry 2000;65(16):4973-83.
2000: Zuben Sauna; Suresh V Ambudkar
Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2515-20.
2000: J J Gribar; M Ramachandra; CA Hrycyna; S Dey; Suresh V Ambudkar
Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system.
The Journal of membrane biology 2000;173(3):203-14.
1999: Suresh V Ambudkar; S Dey; CA Hrycyna; M Ramachandra; Ira Pastan; Michael M Gottesman
Biochemical, cellular, and pharmacological aspects of the multidrug transporter.
Annual review of pharmacology and toxicology 1999;39():361-98.
1998: P Hafkemeyer; S Dey; Suresh V Ambudkar; CA Hrycyna; Ira Pastan; Michael M Gottesman
Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein.
Biochemistry 1998;37(46):16400-9.
1998: CA Hrycyna; L E Airan; ursula germann; Suresh V Ambudkar; Ira Pastan; Michael M Gottesman
Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport.
Biochemistry 1998;37(39):13660-73.
1998: CA Hrycyna; M Ramachandra; Suresh V Ambudkar; Y H Ko; Peter L Pedersen; Ira Pastan; Michael M Gottesman
Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.
The Journal of biological chemistry 1998;273(27):16631-4.
1998: M Ramachandra; Suresh V Ambudkar; D Chen; CA Hrycyna; S Dey; Michael M Gottesman; Ira Pastan
Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state.
Biochemistry 1998;37(14):5010-9.
1998: C G Lee; Michael M Gottesman; Carol Cardarelli; M Ramachandra; Kuan-Teh Jeang; Suresh V Ambudkar; Ira Pastan; S Dey
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.
Biochemistry 1998;37(11):3594-601.
1998: Suresh V Ambudkar
Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells.
Methods in enzymology 1998;292():504-14.
1998: Suresh V Ambudkar; I H Lelong; J Zhang; Carol Cardarelli
Purification and reconstitution of human P-glycoprotein.
Methods in enzymology 1998;292():492-504.
1998: S Dey; M Ramachandra; Ira Pastan; Michael M Gottesman; Suresh V Ambudkar
Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding.
Methods in enzymology 1998;292():318-28.
1997: S Dey; M Ramachandra; Ira Pastan; Michael M Gottesman; Suresh V Ambudkar
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10594-9.
1997: Suresh V Ambudkar; Carol Cardarelli; I Pashinsky; Wilfred D Stein
Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein.
The Journal of biological chemistry 1997;272(34):21160-6.
1996: Michael M Gottesman; Ira Pastan; Suresh V Ambudkar
P-glycoprotein and multidrug resistance.
Current opinion in genetics & development 1996;6(5):610-7.
1996: M Ramachandra; Suresh V Ambudkar; Michael M Gottesman; Ira Pastan; CA Hrycyna
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Molecular biology of the cell 1996;7(10):1485-98.
1996: ursula germann; Timothy C Chambers; Suresh V Ambudkar; Thomas Licht; Carol Cardarelli; Ira Pastan; Michael M Gottesman
Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells.
The Journal of biological chemistry 1996;271(3):1708-16.
1995: Timothy C Chambers; ursula germann; Michael M Gottesman; Ira Pastan; J F Kuo; Suresh V Ambudkar
Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites.
Biochemistry 1995;34(43):14156-62.
1995: ursula germann; Timothy C Chambers; Suresh V Ambudkar; Ira Pastan; Michael M Gottesman
Effects of phosphorylation of P-glycoprotein on multidrug resistance.
Journal of bioenergetics and biomembranes 1995;27(1):53-61.
1995: G L Evans; B Ni; CA Hrycyna; D Chen; Suresh V Ambudkar; Ira Pastan; ursula germann; Michael M Gottesman
Heterologous expression systems for P-glycoprotein: E. coli, yeast, and baculovirus.
Journal of bioenergetics and biomembranes 1995;27(1):43-52.
1995: Suresh V Ambudkar
Purification and reconstitution of functional human P-glycoprotein.
Journal of bioenergetics and biomembranes 1995;27(1):23-9.
1994: Michael M Gottesman; Suresh V Ambudkar; B Ni; J M Aran; Y Sugimoto; Carol Cardarelli; Ira Pastan
Exploiting multidrug resistance to treat cancer.
Cold Spring Harbor symposia on quantitative biology 1994;59():677-83.
1992: Suresh V Ambudkar; I H Lelong; Jin Zhang; Carol Cardarelli; Michael M Gottesman; Ira Pastan
Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8472-6.
1992: Z S Ruan; V Anantharam; I T Crawford; Suresh V Ambudkar; S Y Rhee; M J Allison; Peter C Maloney
Identification, purification, and reconstitution of OxlT, the oxalate: formate antiport protein of Oxalobacter formigenes.
The Journal of biological chemistry 1992;267(15):10537-43.
1990: Suresh V Ambudkar; V Anantharam; Peter C Maloney
UhpT, the sugar phosphate antiporter of Escherichia coli, functions as a monomer.
The Journal of biological chemistry 1990;265(21):12287-92.
1990: Peter C Maloney; Suresh V Ambudkar; V Anatharam; Larry A Sonna; A Varadhachary
Anion-exchange mechanisms in bacteria.
Microbiological reviews 1990;54(1):1-17.
1989: L Bishop; R Agbayani; Suresh V Ambudkar; Peter C Maloney; GF Ames
Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):6953-7.
1989: Peter C Maloney; Suresh V Ambudkar
Functional reconstitution of prokaryote and eukaryote membrane proteins.
Archives of biochemistry and biophysics 1989;269(1):1-10.
1988: Larry A Sonna; Suresh V Ambudkar; Peter C Maloney
The mechanism of glucose 6-phosphate transport by Escherichia coli.
The Journal of biological chemistry 1988;263(14):6625-30.
1987: M P D'Souza; Suresh V Ambudkar; Thomas J August; Peter C Maloney
Reconstitution of the lysosomal proton pump.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(20):6980-4.
1986: Suresh V Ambudkar; A R Lynn; Peter C Maloney; Barry P Rosen
Reconstitution of ATP-dependent calcium transport from streptococci.
The Journal of biological chemistry 1986;261(33):15596-600.
1986: Suresh V Ambudkar; Peter C Maloney
Bacterial anion exchange. Use of osmolytes during solubilization and reconstitution of phosphate-linked antiport from Streptococcus lactis.
The Journal of biological chemistry 1986;261(22):10079-86.
1986: Suresh V Ambudkar; T J Larson; Peter C Maloney
Reconstitution of sugar phosphate transport systems of Escherichia coli.
The Journal of biological chemistry 1986;261(20):9083-6.
1986: Suresh V Ambudkar; Peter C Maloney
Anion exchange in bacteria: reconstitution of phosphate: hexose 6-phosphate antiport from Streptococcus lactis.
Methods in enzymology 1986;125():558-63.
1986: Suresh V Ambudkar; Larry A Sonna; Peter C Maloney
Variable stoichiometry of phosphate-linked anion exchange in Streptococcus lactis: implications for the mechanism of sugar phosphate transport by bacteria.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(2):280-4.
1985: Suresh V Ambudkar; Peter C Maloney
Reconstitution of phosphate-linked antiport from Streptococcus lactis.
Biochemical and biophysical research communications 1985;129(2):568-75.
1985: Peter C Maloney; Suresh V Ambudkar
Anion exchange in bacteria. Variable stoichiometry of phosphate: sugar 6-phosphate antiport.
Annals of the New York Academy of Sciences 1985;456():245-7.
1984: Suresh V Ambudkar; Peter C Maloney
Characterization of phosphate:hexose 6-phosphate antiport in membrane vesicles of Streptococcus lactis.
The Journal of biological chemistry 1984;259(20):12576-85.
1984: Peter C Maloney; Suresh V Ambudkar; J Thomas; L Schiller
Phosphate/hexose 6-phosphate antiport in Streptococcus lactis.
Journal of bacteriology 1984;158(1):238-45.