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Robert Diasio

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Steven M Offer; Kangsheng Wang; Natalie J Wegner; Croix Fossum; Robert B Diasio
Phenotypic profiling of DPYD variations relevant to 5-fluorouracil sensitivity using real-time cellular analysis and in vitro measurement of enzyme activity.
Erin M Bertino; Robert B Diasio; Soledad Fernandez; Nagla A Karim; Gregory A Otterson; Tanios Bekaii-Saab; Miguel A Villalona-Calero
A phase II study of modulated-capecitabine and docetaxel in chemonaive patients with advanced non-small cell lung cancer (NSCLC).
Harry H Yoon; William R Sukov; Anne E Wiktor; Tsung-Teh Wu; Robert B Diasio; Robert B Jenkins; Mark A Lewis; Christopher A Sattler; Qian Shi; Frank A Sinicrope
Adverse prognostic impact of intratumor heterogeneous HER2 gene amplification in patients with esophageal adenocarcinoma.

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2013: Steven M Offer; Kangsheng Wang; Natalie J Wegner; Croix Fossum; Robert B Diasio
Phenotypic profiling of DPYD variations relevant to 5-fluorouracil sensitivity using real-time cellular analysis and in vitro measurement of enzyme activity.
Cancer research 2013;73(6):1958-68.
2013: Erin M Bertino; Robert B Diasio; Soledad Fernandez; Nagla A Karim; Gregory A Otterson; Tanios Bekaii-Saab; Miguel A Villalona-Calero
A phase II study of modulated-capecitabine and docetaxel in chemonaive patients with advanced non-small cell lung cancer (NSCLC).
Lung cancer (Amsterdam, Netherlands) 2013;79(1):27-32.
2012: Harry H Yoon; William R Sukov; Anne E Wiktor; Tsung-Teh Wu; Robert B Diasio; Robert B Jenkins; Mark A Lewis; Christopher A Sattler; Qian Shi; Frank A Sinicrope
Adverse prognostic impact of intratumor heterogeneous HER2 gene amplification in patients with esophageal adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(32):3932-8.
2012: Harry H Yoon; William R Sukov; Anne E Wiktor; Tsung-Teh Wu; Robert B Diasio; Axel Grothey; Robert B Jenkins; Maliha Khan; Christopher A Sattler; Qian Shi; Frank A Sinicrope
Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(2):546-54.
2012: Robert L Foote; Yolanda I Garces; Leonard L Gunderson; Michael G Haddock; Michael G Herman; Jon J Kruse; Nadia N Laack; Robert C Miller; Vickie L Miller; Kenneth R Olivier; Ivy A Petersen; Jose S Pulido; Steven E Schild; Scott L Stafford; Elizabeth Yan; Carola A S Arndt; Christopher R Brent; Steven J. Buskirk; Michelle Clarke; Charles Erlichman; Gary A Ezzell; Robert B Diasio
The clinical case for proton beam therapy.
Radiation oncology (London, England) 2012;7():174.
2011: Harry H Yoon; Stephen D Cassivi; Robert B Diasio; Maliha Khan; Mark A Lewis; Qian Shi; Frank A Sinicrope
Prognostic impact of body mass index stratified by smoking status in patients with esophageal adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(34):4561-7.
2010: Harry H Yoon; Maliha Khan; Qian Shi; Stephen D Cassivi; Tsung-Teh Wu; J Fernando Quevedo; Patrick A Burch; Frank A Sinicrope; Robert B Diasio
The prognostic value of clinical and pathologic factors in esophageal adenocarcinoma: a mayo cohort of 796 patients with extended follow-up after surgical resection.
Mayo Clinic proceedings. Mayo Clinic 2010;85(12):1080-9.
2010: Muhammad Wasif Saif; Sandra Sellers; Robert B Diasio; Jean-Yves Douillard
A phase I dose-escalation study of edotecarin (J-107088) combined with infusional 5-fluorouracil and leucovorin in patients with advanced/metastatic solid tumors.
Anti-cancer drugs 2010;21(7):716-23.
2010: Marwan G Fakih; Gerald Fetterly; Merrill J Egorin; Josephia R Muindi; Igor Espinoza-Delgado; James Zwiebel; Alan Litwin; Julianne L Holleran; Kangsheng Wang; Robert B Diasio
A phase I, pharmacokinetic, and pharmacodynamic study of two schedules of vorinostat in combination with 5-fluorouracil and leucovorin in patients with refractory solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(14):3786-94.
2010: Adam M Lee; Robert B Diasio
ADAM-17: a target to increase chemotherapeutic efficacy in colorectal cancer?
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(13):3319-21.
2009: Hany H Ezzeldin; Edward P Acosta; Lori K Mattison; Jeanne Fourie; Anil Modak; Robert B Diasio
(13)C-5-FU breath test current status and future directions: a comprehensive review.
Journal of breath research 2009;3(4):047002.
2009: Xujun Ma; Hany H Ezzeldin; Robert B Diasio
Histone deacetylase inhibitors: current status and overview of recent clinical trials.
Drugs 2009;69(14):1911-34.
2009: Muhammad Wasif Saif; Sharukh Hashmi; Diana Bell; Robert B Diasio
Prognostication of pancreatic adenocarcinoma by expression of thymidine phosphorylase/dihydropyrimidine dehydrogenase ratio and its correlation with survival.
Expert opinion on drug safety 2009;8(5):507-14.
2008: Hany H Ezzeldin; Robert B Diasio
Predicting fluorouracil toxicity: can we finally do it?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(13):2080-2.
2008: Richie Soong; N Shah; M Salto-Tellez; Bee Choo Tai; R A Soo; Hwan Chour Han; S S Ng; Wan-Loo Tan; Nikolajs Zeps; D Joseph; Robert B Diasio; Barry Iacopetta
Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(5):915-9.
2008: Muhammad Wasif Saif; Sandra Seller; Robert B Diasio
Atypical toxicity associated with 5-Fluororacil in a DPD-deficient patient with pancreatic cancer. Is ethnicity a risk factor?
JOP : Journal of the pancreas 2008;9(2):226-9.
2008: Muhammad Wasif Saif; Megumi Tomita; Leslie Ledbetter; Robert B Diasio
Capecitabine-related cardiotoxicity: recognition and management.
The journal of supportive oncology 2008;6(1):41-8.
2008: Holly R Thomas; Hany Ezzeldin; Vincenzo Guarcello; Lori K Mattison; Brooke L Fridley; Robert B Diasio
Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism.
Pharmacogenetics and genomics 2008;18(1):25-35.
2007: Holly R Thomas; Hany Ezzeldin; Vincenzo Guarcello; Lori K Mattison; Brooke L Fridley; Robert B Diasio
Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism.
Pharmacogenetics and genomics 2007;17(11):973-87.
2007: Muhammad Wasif Saif; Vinni Juneja; Glenda Black; Jennifer Thronton; Martin R Johnson; Robert B Diasio
Palmar-plantar erythrodysesthesia in patients receiving capecitabine and intratumor thymidine phosphorylase and dihydropyrimidine dehydrogenase: is there a pharmacologic explanation?
Supportive cancer therapy 2007;4(4):211-8.
2007: Muhammad Wasif Saif; Hany Ezzeldin; Katisha Vance; Sandra Sellers; Robert B Diasio
DPYD*2A mutation: the most common mutation associated with DPD deficiency.
Cancer chemotherapy and pharmacology 2007;60(4):503-7.
2007: Muhammad Wasif Saif; Glenda Black; Shalija Roy; Diana Bell; Suzanne Russo; Mohamed A Eloubeidi; Adam Steg; Martin R Johnson; Daniel Zelterman; Robert B Diasio
Phase II study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: up-regulation of thymidine phosphorylase.
Cancer journal (Sudbury, Mass.) 2007;13(4):247-56.
2007: Xue Zhang; Richie Soong; Kangsheng Wang; Lin Li; James Davie; Vincenzo Guarcello; Robert B Diasio
Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2007;85(3):337-46.
2007: Peter J O'Dwyer; S Gail Eckhardt; Daniel G Haller; Joel E Tepper; Dennis J Ahnen; Stanley Hamilton; Al B Benson; Mace Rothenberg; Nicholas Petrelli; Heinz-Josef Lenz; Robert B Diasio; Raymond DuBois; Daniel Sargent; Jeff Sloan; C Daniel Johnson; Robert L Comis; Michael J O'Connell
Priorities in colorectal cancer research: recommendations from the Gastrointestinal Scientific Leadership Council of the Coalition of Cancer Cooperative Groups.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(16):2313-21.
2007: Muhammad Wasif Saif; Mohammad Houman Fekrazad; Leslie Ledbetter; Robert B Diasio
Hypokalemia secondary to capecitabine: a hidden toxicity?
Therapeutics and clinical risk management 2007;3(1):177-80.
2007: Xue Zhang; Robert B Diasio
Regulation of human dihydropyrimidine dehydrogenase: implications in the pharmacogenetics of 5-FU-based chemotherapy.
Pharmacogenomics 2007;8(3):257-65.
2007: Muhammad Wasif Saif; Soonmo Peter Kang; Leslie Ledbetter; Adam Steg; Robert B Diasio; Martin R Johnson
Long-term survival on capecitabine in two gemcitabine refractory pancreatic cancer patients. Is there a pharmacogenetic explanation?
JOP : Journal of the pancreas 2007;8(6):799-805.
2007: Richard M Goldberg; Mace L Rothenberg; Eric Van Cutsem; Al B Benson; Charles D Blanke; Robert B Diasio; Axel Grothey; Heinz-Josef Lenz; Neal J Meropol; Ramesh K Ramanathan; Carlos H Roberto Becerra; Rita Wickham; Delma Armstrong; Carol Viele
The continuum of care: a paradigm for the management of metastatic colorectal cancer.
The oncologist 2007;12(1):38-50.
2006: Jessica M Grunda; L Burt Nabors; Cheryl Ann Palmer; David C Chhieng; Adam Steg; Tom Mikkelsen; Robert B Diasio; Kui Zhang; David Allison; William E Grizzle; Wenquan Wang; G Yancey Gillespie; Martin R Johnson
Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM).
Journal of neuro-oncology 2006;80(3):261-74.
2006: Muhammad Wasif Saif; Glenda Black; Martin R Johnson; Suzanne Russo; Robert B Diasio
Radiation recall phenomenon secondary to capecitabine: possible role of thymidine phosphorylase.
Cancer chemotherapy and pharmacology 2006;58(6):771-5.
2006: Muhammad Wasif Saif; Shahrukh Hashmi; Lori K Mattison; William B Donovan; Robert B Diasio
Peripheral neuropathy exacerbation associated with topical 5-fluorouracil.
Anti-cancer drugs 2006;17(9):1095-8.
2006: Lori K Mattison; Jeanne Fourie; Renee A Desmond; Anil Modak; Muhammad Wasif Saif; Robert B Diasio
Increased prevalence of dihydropyrimidine dehydrogenase deficiency in African-Americans compared with Caucasians.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5491-5.
2006: Muhammad Wasif Saif; Aymen A Elfiky; Robert B Diasio
Hand-foot syndrome variant in a dihydropyrimidine dehydrogenase-deficient patient treated with capecitabine.
Clinical colorectal cancer 2006;6(3):219-23.
2006: Neal J Meropol; Philip J Gold; Robert B Diasio; Michael Andria; Mandeep Dhami; Thomas Godfrey; Albert J Kovatich; Kirk A Lund; Edith Mitchell; Roland Schwarting
Thymidine phosphorylase expression is associated with response to capecitabine plus irinotecan in patients with metastatic colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(25):4069-77.
2006: Daniel R Budman; Richie Soong; Anthony Calabro; Julia Tai; Robert B Diasio
Identification of potentially useful combinations of epidermal growth factor receptor tyrosine kinase antagonists with conventional cytotoxic agents using median effect analysis.
Anti-cancer drugs 2006;17(8):921-8.
2006: Muhammad Wasif Saif; Lori K Mattison; Tom Carollo; Hany Ezzeldin; Robert B Diasio
Dihydropyrimidine dehydrogenase deficiency in an Indian population.
Cancer chemotherapy and pharmacology 2006;58(3):396-401.
2006: Hany Ezzeldin; Robert B Diasio
Genetic testing in cancer therapeutics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4137-41.
2006: Jinsheng Yu; howard mcleod; Hany Ezzeldin; Robert B Diasio
Methylation of the DPYD promoter and dihydropyrimidine dehydrogenase deficiency.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(12):3864; author reply 3864.
2006: Xue Zhang; Lin Li; Jeanne Fourie; James Davie; Vincenzo Guarcello; Robert B Diasio
The role of Sp1 and Sp3 in the constitutive DPYD gene expression.
Biochimica et biophysica acta 2006;1759(5):247-56.
2006: Adam Steg; Wenquan Wang; Carmelo Blanquicett; Jessica M Grunda; Isam A Eltoum; Kangsheng Wang; Donald J Buchsbaum; Selwyn M Vickers; Suzanne Russo; Robert B Diasio; Andra R Frost; Albert F LoBuglio; William E Grizzle; Martin R Johnson
Multiple gene expression analyses in paraffin-embedded tissues by TaqMan low-density array: Application to hedgehog and Wnt pathway analysis in ovarian endometrioid adenocarcinoma.
The Journal of molecular diagnostics : JMD 2006;8(1):76-83.
2006: Lori K Mattison; Jeanne Fourie; Yukihiro Hirao; Toshihisa Koga; Renee A Desmond; Jennifer R King; Takefumi Shimizu; Robert B Diasio
The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):549-55.
2006: Robert B Diasio; Jeanne Fourie
Targeting the epidermal growth factor receptor in the treatment of colorectal cancer: state of the art.
Drugs 2006;66(11):1441-63.
2006: Muhammad Wasif Saif; Robert B Diasio
Is capecitabine safe in patients with gastrointestinal cancer and dihydropyrimidine dehydrogenase deficiency?
Clinical colorectal cancer 2006;5(5):359-62.
2006: Heather R Shah; Leslie Ledbetter; Robert B Diasio; Muhammad Wasif Saif
A retrospective study of coagulation abnormalities in patients receiving concomitant capecitabine and warfarin.
Clinical colorectal cancer 2006;5(5):354-8.
2005: Carmelo Blanquicett; Muhammad Wasif Saif; Donald J Buchsbaum; Mohamad A Eloubeidi; Selwyn M Vickers; David C Chhieng; Mark D Carpenter; Jeffrey C Sellers; Suzanne Russo; Robert B Diasio; Martin R Johnson
Antitumor efficacy of capecitabine and celecoxib in irradiated and lead-shielded, contralateral human BxPC-3 pancreatic cancer xenografts: clinical implications of abscopal effects.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(24 Pt 1):8773-81.
2005: Hany Ezzeldin; Adam M Lee; Lori K Mattison; Robert B Diasio
Methylation of the DPYD promoter: an alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(24 Pt 1):8699-705.
2005: Muhammad Wasif Saif; Mohamad A Eloubeidi; Suzanne Russo; Adam Steg; Jennifer Thornton; John B Fiveash; Mark Carpenter; Carmelo Blanquicett; Robert B Diasio; Martin R Johnson
Phase I study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: expression analysis of genes related to outcome.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(34):8679-87.
2005: Richie Soong; Robert B Diasio
Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics.
Pharmacogenomics 2005;6(8):835-47.
2005: Katharina Seck; Silvia Riemer; Ronald Kates; Tobias Ullrich; Verena Lutz; Nadia Harbeck; Manfred Schmitt; Marion Kiechle; Robert B Diasio; Eva Gross
Analysis of the DPYD gene implicated in 5-fluorouracil catabolism in a cohort of Caucasian individuals.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):5886-92.
2005: Muhammad Wasif Saif; Robert B Diasio
Edotecarin: a novel topoisomerase I inhibitor.
Clinical colorectal cancer 2005;5(1):27-36.
2005: William M Boedefeld; Richie Soong; Heidi Weiss; Robert B Diasio; Marshall M Urist; Kirby I Bland; Martin J Heslin
E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7.
Molecular carcinogenesis 2005;43(1):13-7.
2005: Tamila Kindwall-Keller; Gregory A Otterson; Donn Young; Anterpreet Neki; Tamara Criswell; Gerard J Nuovo; Richie Soong; Robert B Diasio; Miguel A Villalona-Calero
Phase II evaluation of docetaxel-modulated capecitabine in previously treated patients with non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):1870-6.
2004: Howard Ozer; Robert B Diasio
Perspectives in the treatment of colorectal cancer.
Seminars in oncology 2004;31(6 Suppl 15):14-8.
2004: Hany Ezzeldin; Cornelia Hoffmayer; Richie Soong; Martin R Johnson; Adam Lee; Martin J Heslin; Robert B Diasio
Simultaneous detection of variable number tandem repeats, single nucleotide polymorphisms, and allelic imbalance in the thymidylate synthase gene enhancer region using denaturing high-performance liquid chromatography.
Analytical biochemistry 2004;334(2):276-83.
2004: Robert B Diasio
Selecting regimens in advanced colon cancer.
Journal of the National Comprehensive Cancer Network : JNCCN 2004;2 Suppl 3():S-19-24.
2004: Muhammad Wasif Saif; Tina E Wood; Philip J McGee; Robert B Diasio
Peripheral neuropathy associated with capecitabine.
Anti-cancer drugs 2004;15(8):767-71.
2004: Hany Ezzeldin; Robert B Diasio
Dihydropyrimidine dehydrogenase deficiency, a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration.
Clinical colorectal cancer 2004;4(3):181-9.
2004: Adam Lee; Hany Ezzeldin; Jeanne Fourie; Robert B Diasio
Dihydropyrimidine dehydrogenase deficiency: impact of pharmacogenetics on 5-fluorouracil therapy.
Clinical advances in hematology & oncology : H&O 2004;2(8):527-32.
2004: Robert B Diasio
Adjuvant chemotherapy for adenocarcinoma of the lung--is the standard of care ready for change?
The New England journal of medicine 2004;350(17):1777-9.
2004: Lori K Mattison; Hany Ezzeldin; Mark Carpenter; Anil Modak; Martin R Johnson; Robert B Diasio
Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(8):2652-8.
2003: Martin J Heslin; Jieming Yan; Heidi Weiss; Lingning Shao; Jill Owens; V Sol Lucas; Robert B Diasio
Dihydropyrimidine dehydrogenase (DPD) rapidly regenerates after inactivation by eniluracil (GW776C85) in primary and metastatic colorectal cancer.
Cancer chemotherapy and pharmacology 2003;52(5):399-404.
2003: Robert B Diasio
Alternative schedules with irinotecan.
Seminars in oncology 2003;30(4 Suppl 12):18-24.
2003: Hany Ezzeldin; Martin R Johnson; Yoshihiro Okamoto; Robert B Diasio
Denaturing high performance liquid chromatography analysis of the DPYD gene in patients with lethal 5-fluorouracil toxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):3021-8.
2003: Anastasios Salesiotis; Richie Soong; Robert B Diasio; Andra R Frost; Kevin J Cullen
Capecitabine induces rapid, sustained response in two patients with extensive oral verrucous carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):580-5.
2002: Carmelo Blanquicett; G Yancey Gillespie; L Burt Nabors; Ryan Miller; Suman Bharara; Donald J Buchsbaum; Robert B Diasio; Martin R Johnson
Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation.
Molecular cancer therapeutics 2002;1(12):1139-45.
2002: Lori K Mattison; Richie Soong; Robert B Diasio
Implications of dihydropyrimidine dehydrogenase on 5-fluorouracil pharmacogenetics and pharmacogenomics.
Pharmacogenomics 2002;3(4):485-92.
2002: Hany Ezzeldin; Yoshihiro Okamoto; Martin R Johnson; Robert B Diasio
A high-throughput denaturing high-performance liquid chromatography method for the identification of variant alleles associated with dihydropyrimidine dehydrogenase deficiency.
Analytical biochemistry 2002;306(1):63-73.
2002: Robert B Diasio
Can eniluracil improve 5-fluorouracil therapy?
Clinical colorectal cancer 2002;2(1):53.
2002: Carmelo Blanquicett; Martin R Johnson; Martin J Heslin; Robert B Diasio
Housekeeping gene variability in normal and carcinomatous colorectal and liver tissues: applications in pharmacogenomic gene expression studies.
Analytical biochemistry 2002;303(2):209-14.
2002: Alex A. Adjei; Joel M Reid; Robert B Diasio; Jeff A Sloan; Deborah A Smith; Joseph Rubin; Henry C Pitot; Steven R Alberts; Richard M Goldberg; Lorelei J Hanson; Pamela J Atherton; Matthew M Ames; Charles Erlichman
Comparative pharmacokinetic study of continuous venous infusion fluorouracil and oral fluorouracil with eniluracil in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(6):1683-91.
2002: Martin R Johnson; Kangsheng Wang; Robert B Diasio
Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(3):768-74.
2002: Lori K Mattison; Martin R Johnson; Robert B Diasio
A comparative analysis of translated dihydropyrimidine dehydrogenase cDNA; conservation of functional domains and relevance to genetic polymorphisms.
Pharmacogenetics 2002;12(2):133-44.
2002: Robert B Diasio
An evolving role for oral fluoropyrimidine drugs.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(4):894-6.
2002: Ryan Miller; Allen Nathaniel Gustin; Donald J Buchsbaum; Selwyn M Vickers; Upender Manne; William E Grizzle; Gretchen A Cloud; Robert B Diasio; Martin R Johnson
Quantitation of cytosine deaminase mRNA by real-time reverse transcription polymerase chain reaction: a sensitive method for assessing 5-fluorocytosine toxicity in vitro.
Analytical biochemistry 2002;301(2):189-99.
2002: Sanford J. Kempin; Jorge Gutierrez; Elizabeth Wilson; Colin Lowery; Robert B Diasio
Raltitrexed (Tomudex): an alternative choice in patients intolerant to 5-fluorouracil.
Cancer investigation 2002;20(7-8):992-5.
2001: Martin J Heslin; J Yan; Martin R Johnson; Heidi Weiss; Robert B Diasio; Marshall M Urist
Role of matrix metalloproteinases in colorectal carcinogenesis.
Annals of surgery 2001;233(6):786-92.
2001: Robert B Diasio
Current status of oral chemotherapy for colorectal cancer.
Oncology (Williston Park, N.Y.) 2001;15(3 Suppl 5):16-20.
2001: Martin R Johnson; Robert B Diasio
Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil.
Advances in enzyme regulation 2001;41():151-7.
2001: Robert B Diasio
Clinical implications of dihydropyrimidine dehydrogenase on 5-FU pharmacology.
Oncology (Williston Park, N.Y.) 2001;15(1 Suppl 2):21-6; discussion 27.
2000: Svetlana A Shestopal; Martin R Johnson; Robert B Diasio
Molecular cloning and characterization of the human dihydropyrimidine dehydrogenase promoter.
Biochimica et biophysica acta 2000;1494(1-2):162-9.
2000: Robert B Diasio
Oral DPD-inhibitory fluoropyrimidine drugs.
Oncology (Williston Park, N.Y.) 2000;14(10 Suppl 9):19-23.
2000: Martin R Johnson; Kangsheng Wang; J B Smith; Martin J Heslin; Robert B Diasio
Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reaction.
Analytical biochemistry 2000;278(2):175-84.
1999: Martin R Johnson; A Hageboutros; Kangsheng Wang; L High; J B Smith; Robert B Diasio
Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(8):2006-11.
1999: Robert B Diasio
Clinical implications of dihydropyrimidine dehydrogenase inhibition.
Oncology (Williston Park, N.Y.) 1999;13(7 Suppl 3):17-21.
1999: Robert B Diasio
Improving fluorouracil chemotherapy with novel orally administered fluoropyrimidines.
Drugs 1999;58 Suppl 3():119-26.
1999: Robert B Diasio
Dihydropyrimidine dehydrogenase and resistance to 5-fluorouracil.
Progress in experimental tumor research 1999;36():115-23.
1998: Robert B Diasio
The role of dihydropyrimidine dehydrogenase (DPD) modulation in 5-FU pharmacology.
Oncology (Williston Park, N.Y.) 1998;12(10 Suppl 7):23-7.
1998: Robert B Diasio
Sorivudine and 5-fluorouracil; a clinically significant drug-drug interaction due to inhibition of dihydropyrimidine dehydrogenase.
British journal of clinical pharmacology 1998;46(1):1-4.
1998: Robert B Diasio
Improving 5-FU with a novel dihydropyrimidine dehydrogenase inactivator.
Oncology (Williston Park, N.Y.) 1998;12(3 Suppl 4):51-6.
1998: Z Lu; Ruiwen Zhang; J T Carpenter; Robert B Diasio
Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: implication for 5-fluorouracil-based chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(2):325-9.
1997: Martin R Johnson; Jieming Yan; L Shao; N Albin; Robert B Diasio
Semi-automated radioassay for determination of dihydropyrimidine dehydrogenase (DPD) activity. Screening cancer patients for DPD deficiency, a condition associated with 5-fluorouracil toxicity.
Journal of chromatography. B, Biomedical sciences and applications 1997;696(2):183-91.
1997: Jieming Yan; Stephen Tyring; M M McCrary; P C Lee; S Haworth; R Raymond; S J Olsen; Robert B Diasio
The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster.
Clinical pharmacology and therapeutics 1997;61(5):563-73.
1997: Martin R Johnson; K Wang; S Tillmanns; N Albin; Robert B Diasio
Structural organization of the human dihydropyrimidine dehydrogenase gene.
Cancer research 1997;57(9):1660-3.
1997: Jieming Yan; Z Lu; GM Walsh; Richard H Wheeler; Robert B Diasio
High-performance liquid chromatographic determination of 9-(3-pyridylmethyl)-9-deazaguanine (BCX-34) in biological fluids.
Journal of chromatography. B, Biomedical sciences and applications 1997;690(1-2):295-303.
1997: W Jiang; Z Lu; Y He; Robert B Diasio
Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: implication in 5-fluorouracil-based chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(3):395-9.
1997: Robert B Diasio; Martin R Johnson; N Albin
Mutations at codon 974 of the DPYD gene are a rare event.
British journal of cancer 1997;76(8):1113.
1996: N Albin; Martin R Johnson; Robert B Diasio
cDNA cloning of bovine liver dihydropyrimidine dehydrogenase.
DNA sequence : the journal of DNA sequencing and mapping 1996;6(4):243-50.
1995: Z Lu; Ruiwen Zhang; Robert B Diasio
Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy.
Clinical pharmacology and therapeutics 1995;58(5):512-22.
1995: S Agrawal; X Zhang; Z Lu; H Zhao; J M Tamburin; J Yan; H Cai; Robert B Diasio; I Habus; Z Jiang
Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration.
Biochemical pharmacology 1995;50(4):571-6.
1995: Ruiwen Zhang; Z Lu; H Zhao; X Zhang; Robert B Diasio; I Habus; Z Jiang; R P Iyer; D Yu; S Agrawal
In vivo stability, disposition and metabolism of a "hybrid" oligonucleotide phosphorothioate in rats.
Biochemical pharmacology 1995;50(4):545-56.
1995: Ruiwen Zhang; Z Lu; X Zhang; H Zhao; Robert B Diasio; T Liu; Z Jiang; S Agrawal
In vivo stability and disposition of a self-stabilized oligodeoxynucleotide phosphorothioate in rats.
Clinical chemistry 1995;41(6 Pt 1):836-43.
1995: Ruiwen Zhang; Robert B Diasio; Z Lu; T Liu; Z Jiang; W M Galbraith; S Agrawal
Pharmacokinetics and tissue distribution in rats of an oligodeoxynucleotide phosphorothioate (GEM 91) developed as a therapeutic agent for human immunodeficiency virus type-1.
Biochemical pharmacology 1995;49(7):929-39.
1995: Robert B Diasio; Z Lu; Ruiwen Zhang; H S Shahinian
Fluoropyrimidine catabolism.
Cancer treatment and research 1995;78():71-93.
1994: Charles N Falany; Martin R Johnson; Stephen Barnes; Robert B Diasio
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
The Journal of biological chemistry 1994;269(30):19375-9.
1994: Robert B Diasio; André B P van Kuilenburg; Z Lu; Ruiwen Zhang; Henk Van Lenthe; Henk D Bakker; A H Van Gennip
Determination of dihydropyrimidine dehydrogenase (DPD) in fibroblasts of a DPD deficient pediatric patient and family members using a polyclonal antibody to human DPD.
Advances in experimental medicine and biology 1994;370():7-10.
1993: Z Lu; Ruiwen Zhang; Robert B Diasio
Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy.
Cancer research 1993;53(22):5433-8.
1993: Z H Lu; Ruiwen Zhang; Robert B Diasio
Comparison of dihydropyrimidine dehydrogenase from human, rat, pig and cow liver. Biochemical and immunological properties.
Biochemical pharmacology 1993;46(5):945-52.
1993: Ruiwen Zhang; Z Lu; T Liu; Seng-Jaw Soong; Robert B Diasio
Relationship between circadian-dependent toxicity of 5-fluorodeoxyuridine and circadian rhythms of pyrimidine enzymes: possible relevance to fluoropyrimidine chemotherapy.
Cancer research 1993;53(12):2816-22.
1993: Ruiwen Zhang; T Liu; Seng-Jaw Soong; Robert B Diasio
A mathematical model of the kinetics and tissue distribution of 2-fluoro-beta-alanine, the major catabolite of 5-fluorouracil.
Biochemical pharmacology 1993;45(10):2063-9.
1993: Ruiwen Zhang; Z Lu; T Liu; Seng-Jaw Soong; Robert B Diasio
Circadian rhythm of rat spleen cytoplasmic thymidine kinase.
Biochemical pharmacology 1993;45(5):1115-9.
1993: A P Lyss; R C Lilenbaum; B E Harris; Robert B Diasio
Severe 5-fluorouracil toxicity in a patient with decreased dihydropyrimidine dehydrogenase activity.
Cancer investigation 1993;11(2):239-40.
1993: J B Kwakye; Stephen Barnes; Robert B Diasio
Identification of bile acid coenzyme A synthetase in rat kidney.
Journal of lipid research 1993;34(1):95-9.
1992: Z H Lu; Ruiwen Zhang; Robert B Diasio
Purification and characterization of dihydropyrimidine dehydrogenase from human liver.
The Journal of biological chemistry 1992;267(24):17102-9.
1992: M P Stagg; E M Cretton; L Kidd; Robert B Diasio; Jean-Pierre Sommadossi
Clinical pharmacokinetics of 3'-azido-3'-deoxythymidine (zidovudine) and catabolites with formation of a toxic catabolite, 3'-amino-3'-deoxythymidine.
Clinical pharmacology and therapeutics 1992;51(6):668-76.
1992: R Zhang; Stephen Barnes; Robert B Diasio
Differential intestinal deconjugation of taurine and glycine bile acid N-acyl amidates in rats.
The American journal of physiology 1992;262(2 Pt 1):G351-8.
1991: J B Kwakye; Martin R Johnson; Stephen Barnes; W E Grizzle; Robert B Diasio
Identification of bile acid-CoA: amino acid N-acyltransferase in rat kidney.
The Biochemical journal 1991;280 ( Pt 3)():821-4.
1991: B E Harris; J T Carpenter; Robert B Diasio
Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome.
Cancer 1991;68(3):499-501.
1991: G C Daher; Fardos N M Naguib; Mahmoud el Kouni; R W Zhang; Seng-Jaw Soong; Robert B Diasio
Inhibition of fluoropyrimidine catabolism by benzyloxybenzyluracil. Possible relevance to regional chemotherapy.
Biochemical pharmacology 1991;41(12):1887-93.
1991: Martin R Johnson; Stephen Barnes; J B Kwakye; Robert B Diasio
Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver.
The Journal of biological chemistry 1991;266(16):10227-33.
1991: David Sweeny; Stephen Barnes; Robert B Diasio
Bile acid conjugation pattern in the isolated perfused rat liver during infusion of an amino acid formulation.
JPEN. Journal of parenteral and enteral nutrition 1991;15(3):303-6.
1991: R W Zhang; Stephen Barnes; Robert B Diasio
Disposition and metabolism of 2-fluoro-beta-alanine conjugates of bile acids following secretion into bile.
Biochimica et biophysica acta 1991;1096(3):179-86.
1991: G C Daher; B E Harris; E M Willard; Robert B Diasio
Biochemical basis for circadian-dependent metabolism of fluoropyrimidines.
Annals of the New York Academy of Sciences 1991;618():350-61.
1991: J B Kwakye; Martin R Johnson; Stephen Barnes; Robert B Diasio
A comparative study of bile acid CoA:amino acid:N-acyltransferase (BAT) from four mammalian species.
Comparative biochemistry and physiology. B, Comparative biochemistry 1991;100(1):131-6.
1991: G C Daher; R W Zhang; Seng-Jaw Soong; Robert B Diasio
Circadian variation of fluoropyrimidine catabolic enzymes in rat liver: possible relevance to 5-fluorodeoxyuridine chemotherapy.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(1):285-7.
1990: Martin R Johnson; Stephen Barnes; David Sweeny; Robert B Diasio
2-Fluoro-beta-alanine, a previously unrecognized substrate for bile acid coenzyme A:amino acid:N-acyltransferase from human liver.
Biochemical pharmacology 1990;40(6):1241-6.
1990: David Sweeny; G Daher; Stephen Barnes; Robert B Diasio
Biological properties of the 2-fluoro-beta-alanine conjugates of cholic acid and chenodeoxycholic acid in the isolated perfused rat liver.
Biochimica et biophysica acta 1990;1054(1):21-5.
1990: B E Harris; R Song; Seng-Jaw Soong; Robert B Diasio
Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion.
Cancer research 1990;50(1):197-201.
1990: G C Daher; B E Harris; Robert B Diasio
Metabolism of pyrimidine analogues and their nucleosides.
Pharmacology & therapeutics 1990;48(2):189-222.
1989: B E Harris; R L Song; Seng-Jaw Soong; Robert B Diasio
Circadian variation of 5-fluorouracil catabolism in isolated perfused rat liver.
Cancer research 1989;49(23):6610-4.
1989: Martin R Johnson; Stephen Barnes; Robert B Diasio
Radioassay of bile acid coenzyme A:glycine/taurine: N-acyltransferase using an n-butanol solvent extraction procedure.
Analytical biochemistry 1989;182(2):360-5.
1989: Robert B Diasio; B E Harris
Clinical pharmacology of 5-fluorouracil.
Clinical pharmacokinetics 1989;16(4):215-37.
1988: B E Harris; R L Song; Y J He; Seng-Jaw Soong; Robert B Diasio
Circadian rhythm of rat liver dihydropyrimidine dehydrogenase. Possible relevance to fluoropyrimidine chemotherapy.
Biochemical pharmacology 1988;37(24):4759-62.
1988: David Sweeny; M Martin; Robert B Diasio
N-chenodeoxycholyl-2-fluoro-beta-alanine: a biliary metabolite of 5-fluorouracil in humans.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(6):892-4.
1988: David Sweeny; Stephen Barnes; Robert B Diasio
Formation of conjugates of 2-fluoro-beta-alanine and bile acids during the metabolism of 5-fluorouracil and 5-fluoro-2-deoxyuridine in the isolated perfused rat liver.
Cancer research 1988;48(8):2010-4.
1988: Robert B Diasio; T L Beavers; J T Carpenter
Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity.
The Journal of clinical investigation 1988;81(1):47-51.
1987: David Sweeny; Stephen Barnes; G D Heggie; Robert B Diasio
Metabolism of 5-fluorouracil to an N-cholyl-2-fluoro-beta-alanine conjugate: previously unrecognized role for bile acids in drug conjugation.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(15):5439-43.