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María Diaz-Meco

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
72
Moscat, Jorge
9
Serrano, Manuel
8
Leitges, Michael
7
Wooten, Marie
6
Martin, Pilar
5
Rennert, Paul
4
Seibenhener, Lamar
4
Flores, Juana
4
Duran, Angeles
3
Durán, Angeles
3
Collado, Manuel
3
Frutos, S
3
Garcia-Cao, Isabel
3
Geetha, Thangiah
3
Lallena, María José

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Publications

TOP 3
Moscat J; Diaz-Meco M T; Wooten M W
Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex.
Moscat Jorge; Diaz-Meco Maria T
To aggregate or not to aggregate? A new role for p62.
Diaz-Meco Maria T; Abu-Baker Shadi
The Par-4/PTEN connection in tumor suppression.

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All Publications

2009: Moscat J; Diaz-Meco M T; Wooten M W
Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex.
Cell death and differentiation 2009;16(11):1426-37.
2009: Moscat Jorge; Diaz-Meco Maria T
To aggregate or not to aggregate? A new role for p62.
EMBO reports 2009;10(8):804.
2009: Diaz-Meco Maria T; Abu-Baker Shadi
The Par-4/PTEN connection in tumor suppression.
Cell cycle (Georgetown, Tex.) 2009;8(16):2518-22.
2009: Fernandez-Marcos Pablo J; Abu-Baker Shadi; Joshi Jayashree; Galvez Anita; Castilla Elias A; Cañamero Marta; Collado Manuel; Saez Carmen; Moreno-Bueno Gema; Palacios Jose; Leitges Michael; Serrano Manuel; Moscat Jorge; Diaz-Meco Maria T
Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12962-7.
2009: Moscat Jorge; Diaz-Meco Maria T
p62 at the crossroads of autophagy, apoptosis, and cancer.
Cell 2009;137(6):1001-4.
2009: Yang Jun-Qi; Leitges Michael; Duran Angeles; Diaz-Meco Maria T; Moscat Jorge
Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(4):1099-104.
2008: Diaz-Meco Maria T; Moscat Jorge
Akt regulation and lung cancer: a novel role and mechanism of action for the tumor suppressor Par-4.
Cell cycle (Georgetown, Tex.) 2008;7(18):2817-20.
2008: Joshi Jayashree; Fernandez-Marcos Pablo J; Galvez Anita; Amanchy Ramars; Linares Juan F; Duran Angeles; Pathrose Peterson; Leitges Michael; Cañamero Marta; Collado Manuel; Salas Clara; Serrano Manuel; Moscat Jorge; Diaz-Meco Maria T
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.
The EMBO journal 2008;27(16):2181-93.
2008: Ramesh Babu J; Lamar Seibenhener M; Peng Junmin; Strom Anna-Lena; Kemppainen Robert; Cox Nancy; Zhu Haining; Wooten Michael C; Diaz-Meco María T; Moscat Jorge; Wooten Marie W
Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.
Journal of neurochemistry 2008;106(1):107-20.
2008: Duran Angeles; Linares Juan F; Galvez Anita S; Wikenheiser Kathryn; Flores Juana M; Diaz-Meco Maria T; Moscat Jorge
The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.
Cancer cell 2008;13(4):343-54.
2008: Wooten Marie W; Geetha Thangiah; Babu J Ramesh; Seibenhener M Lamar; Peng Junmin; Cox Nancy; Diaz-Meco Maria-T; Moscat Jorge
Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins.
The Journal of biological chemistry 2008;283(11):6783-9.
2007: Moreno-Bueno Gema; Fernandez-Marcos Pablo J; Collado Manuel; Tendero Mercedes J; Rodriguez-Pinilla Socorro M; Garcia-Cao Isabel; Hardisson David; Diaz-Meco Maria T; Moscat Jorge; Serrano Manuel; Palacios Jose
Inactivation of the candidate tumor suppressor par-4 in endometrial cancer.
Cancer research 2007;67(5):1927-34.
2007: Moscat Jorge; Diaz-Meco María T; Wooten Marie W
Signal integration and diversification through the p62 scaffold protein.
Trends in biochemical sciences 2007;32(2):95-100.
2006: Moscat Jorge; Diaz-Meco Maria T; Albert Armando; Campuzano Sonsoles
Cell signaling and function organized by PB1 domain interactions.
Molecular cell 2006;23(5):631-40.
2006: Martin Pilar; Diaz-Meco Maria T; Moscat Jorge
The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation.
The EMBO journal 2006;25(15):3524-33.
2006: Moscat J; Rennert P; Diaz-Meco M T
PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways.
Cell death and differentiation 2006;13(5):702-11.
2006: Rodriguez Angelina; Durán Angeles; Selloum Mohammed; Champy Marie-France; Diez-Guerra Francisco J; Flores Juana María; Serrano Manuel; Auwerx Johan; Diaz-Meco María T; Moscat Jorge
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.
Cell metabolism 2006;3(3):211-22.
2005: Wooten Marie W; Geetha Thangiah; Seibenhener M Lamar; Babu J Ramesh; Diaz-Meco Maria T; Moscat Jorge
The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination.
The Journal of biological chemistry 2005;280(42):35625-9.
2005: Martin Pilar; Villares Ricardo; Rodriguez-Mascarenhas Sandra; Zaballos Angel; Leitges Michael; Kovac Judit; Sizing Irene; Rennert Paul; Márquez Gabriel; Martínez-A Carlos; Diaz-Meco María T; Moscat Jorge
Control of T helper 2 cell function and allergic airway inflammation by PKCzeta.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9866-71.
2005: García-Cao Isabel; Duran Angeles; Collado Manuel; Carrascosa Maria J; Martín-Caballero Juan; Flores Juana M; Diaz-Meco Maria T; Moscat Jorge; Serrano Manuel
Tumour-suppression activity of the proapoptotic regulator Par4.
EMBO reports 2005;6(6):577-83.
2004: Durán Angeles; Rodriguez Angelina; Martin Pilar; Serrano Manuel; Flores Juana Maria; Leitges Michael; Diaz-Meco María T; Moscat Jorge
Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis.
The EMBO journal 2004;23(23):4595-605.
2004: Sole Carme; Dolcet Xavier; Segura Miguel F; Gutierrez Humberto; Diaz-Meco Maria-Teresa; Gozzelino Raffaella; Sanchis Daniel; Bayascas Jose R; Gallego Carme; Moscat Jorge; Davies Alun M; Comella Joan X
The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling.
The Journal of cell biology 2004;167(3):479-92.
2004: Durán Angeles; Serrano Manuel; Leitges Michael; Flores Juana M; Picard Sylvain; Brown Jacques P; Moscat Jorge; Diaz-Meco Maria T
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.
Developmental cell 2004;6(2):303-9.
2003: Lafuente María José; Martin Pilar; Garcia-Cao Isabel; Diaz-Meco María Teresa; Serrano Manuel; Moscat Jorge
Regulation of mature T lymphocyte proliferation and differentiation by Par-4.
The EMBO journal 2003;22(18):4689-98.
2003: Duran Angeles; Diaz-Meco María T; Moscat Jorge
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.
The EMBO journal 2003;22(15):3910-8.
2003: Moscat Jorge; Diaz-Meco Maria T
Par-4 keeps the atypical PKCs at bay.
Cell cycle (Georgetown, Tex.) 2003;2(2):71-2.
2003: Garcia-Cao Isabel; Lafuente María José; Criado Luis M; Diaz-Meco María Teresa; Serrano Manuel; Moscat Jorge
Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38.
EMBO reports 2003;4(3):307-12.
2003: Moscat Jorge; Diaz-Meco María T; Rennert Paul
NF-kappaB activation by protein kinase C isoforms and B-cell function.
EMBO reports 2003;4(1):31-6.
2002: Avila Antonia; Silverman Neal; Diaz-Meco María T; Moscat Jorge
The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway.
Molecular and cellular biology 2002;22(24):8787-95.
2002: Martin Pilar; Duran Angeles; Minguet Susana; Gaspar María-Luisa; Diaz-Meco Maria-Teresa; Rennert Paul; Leitges Michael; Moscat Jorge
Role of zeta PKC in B-cell signaling and function.
The EMBO journal 2002;21(15):4049-57.
2002: Ponting Chris P; Ito Takashi; Moscat Jorge; Diaz-Meco María T; Inagaki Fuyuhiko; Sumimoto Hideki
OPR, PC and AID: all in the PB1 family.
Trends in biochemical sciences 2002;27(1):10.
2002: Moscat Jorge; Diaz-Meco María T
The atypical PKC scaffold protein P62 is a novel target for anti-inflammatory and anti-cancer therapies.
Advances in enzyme regulation 2002;42():173-9.
2001: Wooten M W; Vandenplas M L; Seibenhener M L; Geetha T; Diaz-Meco M T
Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway.
Molecular and cellular biology 2001;21(24):8414-27.
2001: Leitges M; Sanz L; Martin P; Duran A; Braun U; García J F; Camacho F; Diaz-Meco M T; Rennert P D; Moscat J
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.
Molecular cell 2001;8(4):771-80.
2001: Wooten M W; Seibenhener M L; Mamidipudi V; Diaz-Meco M T; Barker P A; Moscat J
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor.
The Journal of biological chemistry 2001;276(11):7709-12.
2001: Diaz-Meco M T; Moscat J
MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling.
Molecular and cellular biology 2001;21(4):1218-27.
2001: Moscat J; Sanz L; Sanchez P; Diaz-Meco M T
Regulation and role of the atypical PKC isoforms in cell survival during tumor transformation.
Advances in enzyme regulation 2001;41():99-120.
2000: Moscat J; Diaz-Meco M T
The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters.
EMBO reports 2000;1(5):399-403.
2000: van der Houven van Oordt W; Diaz-Meco M T; Lozano J; Krainer A R; Moscat J; Cáceres J F
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation.
The Journal of cell biology 2000;149(2):307-16.
2000: Sanz L; Diaz-Meco M T; Nakano H; Moscat J
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway.
The EMBO journal 2000;19(7):1576-86.
1999: Barradas M; Monjas A; Diaz-Meco M T; Serrano M; Moscat J
The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression.
The EMBO journal 1999;18(22):6362-9.
1999: Diaz-Meco M T; Lallena M J; Monjas A; Frutos S; Moscat J
Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis.
The Journal of biological chemistry 1999;274(28):19606-12.
1999: Sanz L; Sanchez P; Lallena M J; Diaz-Meco M T; Moscat J
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.
The EMBO journal 1999;18(11):3044-53.
1999: Frutos S; Moscat J; Diaz-Meco M T
Cleavage of zetaPKC but not lambda/iotaPKC by caspase-3 during UV-induced apoptosis.
The Journal of biological chemistry 1999;274(16):10765-70.
1999: Lallena M J; Diaz-Meco M T; Bren G; Payá C V; Moscat J
Activation of IkappaB kinase beta by protein kinase C isoforms.
Molecular and cellular biology 1999;19(3):2180-8.
1998: Sanchez P; De Carcer G; Sandoval I V; Moscat J; Diaz-Meco M T
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.
Molecular and cellular biology 1998;18(5):3069-80.
1998: Berra E; Diaz-Meco M T; Moscat J
The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway.
The Journal of biological chemistry 1998;273(17):10792-7.
1997: Berra E; Municio M M; Sanz L; Frutos S; Diaz-Meco M T; Moscat J
Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade.
Molecular and cellular biology 1997;17(8):4346-54.
1997: Cai H; Smola U; Wixler V; Eisenmann-Tappe I; Diaz-Meco M T; Moscat J; Rapp U; Cooper G M
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase.
Molecular and cellular biology 1997;17(2):732-41.
1996: Kirstein M; Sanz L; Quiñones S; Moscat J; Diaz-Meco M T; Saus J
Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.
The Journal of biological chemistry 1996;271(30):18231-6.
1996: Diaz-Meco M T; Municio M M; Sanchez P; Lozano J; Moscat J
Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo.
Molecular and cellular biology 1996;16(1):105-14.
1996: Folgueira L; McElhinny J A; Bren G D; MacMorran W S; Diaz-Meco M T; Moscat J; Paya C V
Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes.
Journal of virology 1996;70(1):223-31.
1995: Bjørkøy G; Overvatn A; Diaz-Meco M T; Moscat J; Johansen T
Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C.
The Journal of biological chemistry 1995;270(36):21299-306.
1995: Sanz L; Moscat J; Diaz-Meco M T
Molecular characterization of a novel transcription factor that controls stromelysin expression.
Molecular and cellular biology 1995;15(6):3164-70.
1995: Municio M M; Lozano J; Sánchez P; Moscat J; Diaz-Meco M T
Identification of heterogeneous ribonucleoprotein A1 as a novel substrate for protein kinase C zeta.
The Journal of biological chemistry 1995;270(26):15884-91.
1994: Diaz-Meco M T; Lozano J; Municio M M; Berra E; Frutos S; Sanz L; Moscat J
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.
The Journal of biological chemistry 1994;269(50):31706-10.
1994: Lozano J; Berra E; Municio M M; Diaz-Meco M T; Dominguez I; Sanz L; Moscat J
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.
The Journal of biological chemistry 1994;269(30):19200-2.
1994: Diaz-Meco M T; Dominguez I; Sanz L; Dent P; Lozano J; Municio M M; Berra E; Hay R T; Sturgill T W; Moscat J
zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.
The EMBO journal 1994;13(12):2842-8.
1994: Sanz L; Berra E; Municio M M; Dominguez I; Lozano J; Johansen T; Moscat J; Diaz-Meco M T
Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element.
The Journal of biological chemistry 1994;269(13):10044-9.
1994: Johansen T; Bjørkøy G; Overvatn A; Diaz-Meco M T; Traavik T; Moscat J
NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype.
Molecular and cellular biology 1994;14(1):646-54.
1993: Cai H; Erhardt P; Troppmair J; Diaz-Meco M T; Sithanandam G; Rapp U R; Moscat J; Cooper G M
Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.
Molecular and cellular biology 1993;13(12):7645-51.
1993: Arenzana-Seisdedos F; Fernandez B; Dominguez I; Jacqué J M; Thomas D; Diaz-Meco M T; Moscat J; Virelizier J L
Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes.
Journal of virology 1993;67(11):6596-604.
1993: Diaz-Meco M T; Berra E; Municio M M; Sanz L; Lozano J; Dominguez I; Diaz-Golpe V; Lain de Lera M T; Alcamí J; Payá C V
A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.
Molecular and cellular biology 1993;13(8):4770-5.
1993: Berra E; Diaz-Meco M T; Dominguez I; Municio M M; Sanz L; Lozano J; Chapkin R S; Moscat J
Protein kinase C zeta isoform is critical for mitogenic signal transduction.
Cell 1993;74(3):555-63.
1993: Dominguez I; Sanz L; Arenzana-Seisdedos F; Diaz-Meco M T; Virelizier J L; Moscat J
Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes.
Molecular and cellular biology 1993;13(2):1290-5.
1992: Cai H; Erhardt P; Szeberényi J; Diaz-Meco M T; Johansen T; Moscat J; Cooper G M
Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction.
Molecular and cellular biology 1992;12(12):5329-35.
1992: Dominguez I; Diaz-Meco M T; Municio M M; Berra E; García de Herreros A; Cornet M E; Sanz L; Moscat J
Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes.
Molecular and cellular biology 1992;12(9):3776-83.
1992: Diaz-Meco M T; Dominguez I; Sanz L; Municio M M; Berra E; Cornet M E; Garcia de Herreros A; Johansen T; Moscat J
Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals.
Molecular and cellular biology 1992;12(1):302-8.
1991: Diaz-Meco M T; Quiñones S; Municio M M; Sanz L; Bernal D; Cabrero E; Saus J; Moscat J
Protein kinase C-independent expression of stromelysin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C.
The Journal of biological chemistry 1991;266(33):22597-602.
1991: Dominguez I; Marshall M S; Gibbs J B; García de Herreros A; Cornet M E; Graziani G; Diaz-Meco M T; Johansen T; McCormick F; Moscat J
Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C.
The EMBO journal 1991;10(11):3215-20.
1991: García de Herreros A; Dominguez I; Diaz-Meco M T; Graziani G; Cornett M E; Guddal P H; Johansen T; Moscat J
Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21.
The Journal of biological chemistry 1991;266(11):6825-9.
1991: Diaz-Laviada I; Larrodera P; Nieto J L; Cornet M E; Diaz-Meco M T; Sanchez M J; Guddal P H; Johansen T; Haro A; Moscat J
Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C.
The Journal of biological chemistry 1991;266(2):1170-6.
1990: Diaz-Laviada I; Larrodera P; Diaz-Meco M T; Cornet M E; Guddal P H; Johansen T; Moscat J
Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes.
The EMBO journal 1990;9(12):3907-12.
1990: Lopez-Barahona M; Kaplan P L; Cornet M E; Diaz-Meco M T; Larrodera P; Diaz-Laviada I; Municio A M; Moscat J
Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade.
The Journal of biological chemistry 1990;265(16):9022-6.
1990: Larrodera P; Cornet M E; Diaz-Meco M T; Lopez-Barahona M; Diaz-Laviada I; Guddal P H; Johansen T; Moscat J
Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis.
Cell 1990;61(6):1113-20.
1989: Moscat J; Cornet M E; Diaz-Meco M T; Larrodera P; Lopez-Alanon D; Lopez-Barahona M
Activation of phosphatidylcholine-specific phospholipase C in cell growth and oncogene transformation.
Biochemical Society transactions 1989;17(6):988-91.
1989: Diaz-Meco M T; Larrodera P; Lopez-Barahona M; Cornet M E; Barreno P G; Moscat J
Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by muscarinic agonists.
The Biochemical journal 1989;263(1):115-20.

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