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David Dicker

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Disorders

Colonic Neoplasms

Procedures

Physiology

Genes & Molecular Sequences

Genes, p53

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Publications

TOP 3
Joshua E Allen; David T Dicker; Nathan G Dolloff; Gabriel Krigsfeld; Patrick A Mayes; Evangelos Messaris; Akshal S Patel; Luv Patel; Kimberly A Scata; Wenge Wang; Gen Sheng Wu; Jun-Ying Zhou; Wafik S El-Deiry
Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects.
Joshua E Allen; Shantu Amin; David T Dicker; Jean-Nicolas Gallant; Rosalyn B Irby; Arun K Sharma; Wafik S El-Deiry
The Akt inhibitor ISC-4 synergizes with cetuximab in 5-FU-resistant colon cancer.
Nathan G Dolloff; Joshua E Allen; Nicole Aqui; David T Dicker; Jozef Malysz; Giampaolo Talamo; Dan Vogl; Wafik S El-Deiry
Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9.

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All Publications

2013: Joshua E Allen; David T Dicker; Nathan G Dolloff; Gabriel Krigsfeld; Patrick A Mayes; Evangelos Messaris; Akshal S Patel; Luv Patel; Kimberly A Scata; Wenge Wang; Gen Sheng Wu; Jun-Ying Zhou; Wafik S El-Deiry
Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects.
Science translational medicine 2013;5(171):171ra17.
2013: Joshua E Allen; Shantu Amin; David T Dicker; Jean-Nicolas Gallant; Rosalyn B Irby; Arun K Sharma; Wafik S El-Deiry
The Akt inhibitor ISC-4 synergizes with cetuximab in 5-FU-resistant colon cancer.
PloS one 2013;8(3):e59380.
2012: Nathan G Dolloff; Joshua E Allen; Nicole Aqui; David T Dicker; Jozef Malysz; Giampaolo Talamo; Dan Vogl; Wafik S El-Deiry
Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9.
Molecular cancer therapeutics 2012;11(11):2321-30.
2012: Hairong Cheng; David T Dicker; Joshua E Allen; Bo Hong; Robin Humphreys; Yingqiu Y Liu; Guihua Tai; Lanlan Zhou; Wafik S El-Deiry
Mitomycin C potentiates TRAIL-induced apoptosis through p53-independent upregulation of death receptors: evidence for the role of c-Jun N-terminal kinase activation.
Cell cycle (Georgetown, Tex.) 2012;11(17):3312-23.
2011: Niklas K Finnberg; Lori S Hart; Zachary B Rodgers; David T Dicker; Nathan G Dolloff; Wafik S El-Deiry
High-resolution imaging and antitumor effects of GFP(+) bone marrow-derived cells homing to syngeneic mouse colon tumors.
The American journal of pathology 2011;179(5):2169-76.
2011: Akshal S Patel; Kristi L Peters; Jonas M Sheehan; Joshua E Allen; David T Dicker; Michael J Glantz; Wafik S El-Deiry
Identification and enumeration of circulating tumor cells in the cerebrospinal fluid of breast cancer patients with central nervous system metastases.
Oncotarget 2011;2(10):752-60.
2011: LanLan Zhou; David T Dicker; Robin C Humphreys; Wenge Wang; Wafik S El-Deiry
Prediction of proapoptotic anticancer therapeutic response in vivo based on cell death visualization and TRAIL death ligand-receptor interaction.
Cancer biology & therapy 2011;12(4):335-48.
2011: Nathan G Dolloff; Robin C Humphreys; Lin Z Li; Xiahong Ma; David T Dicker; Wafik S El-Deiry
Spectral imaging-based methods for quantifying autophagy and apoptosis.
Cancer biology & therapy 2011;12(4):349-56.
2011: Patrick A Mayes; Rosalie C Sears; Joshua E Allen; J Martin Brown; Colin J Daniel; David T Dicker; Nathan G Dolloff; Jay F Dorsey; Emma E Furth; Lori S Hart; David I H Jee; Peter S Klein; Kageaki Kuribayashi; J Judy Liu; Yingqiu Y Liu; Wafik S El-Deiry
Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1.
Cancer research 2011;71(15):5265-75.
2011: Bishoy Faltas; Harold A Harvey; Yixing Jiang; Jamal Joudeh; Arunasalam Navaraj; Kristi Peters; Amer Zeidan; Joshua E Allen; Avisnata Das; David T Dicker; Nathan G Dolloff; Wafik S El-Deiry
Identifying circulating tumor stem cells that matter: the key to prognostication and therapeutic targeting.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(21):2946-7; author reply 2947-8.
2011: Nathan G Dolloff; Lori S Hart; Robin Humphreys; Patrick A Mayes; David T Dicker; Wafik S El-Deiry
Off-target lapatinib activity sensitizes colon cancer cells through TRAIL death receptor up-regulation.
Science translational medicine 2011;3(86):86ra50.
2009: Elizabeth M Matthew; Lori S Hart; Aristotelis Astrinidis; Arunasalam Navaraj; Nathan G Dolloff; David T Dicker; Elizabeth Petri Henske; Wafik S El-Deiry
The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.
Cell cycle (Georgetown, Tex.) 2009;8(24):4168-75.
2009: Arunasalam Navaraj; Niklas Finnberg; David T Dicker; Wensheng Yang; Elizabeth M Matthew; Wafik S El-Deiry
Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.
Cancer biology & therapy 2009;8(24):2417-44.
2009: Sharyn I Katz; Lanlan Zhou; Grace Chao; Charles D Smith; Thomas Ferrara; Wenge Wang; David T Dicker; Wafik S El-Deiry
Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma.
Cancer biology & therapy 2009;8(24):2406-16.
2009: Jay F Dorsey; Akiva Mintz; Xiaobing Tian; Melissa L Dowling; John P Plastaras; David T Dicker; Gary D Kao; Wafik S El-Deiry
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative in vivo effects against glioblastoma multiforme cells.
Molecular cancer therapeutics 2009;8(12):3285-95.
2009: Catherine Huang; Xiang M Zhang; Raluca T Tavaluc; Lori S Hart; David T Dicker; Wenge Wang; Wafik S El-Deiry
The combination of 5-fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon cancer stem cells.
Cancer biology & therapy 2009;8(22):2186-93.
2009: Joshua E Allen; Lori S Hart; David T Dicker; Wenge Wang; Wafik S El-Deiry
Visualization and enrichment of live putative cancer stem cell populations following p53 inactivation or Bax deletion using non-toxic fluorescent dyes.
Cancer biology & therapy 2009;8(22):2194-205.
2008: Kageaki Kuribayashi; Gabriel Krigsfeld; Wenge Wang; Jing Xu; Patrick A Mayes; David T Dicker; Gen Sheng Wu; Wafik S El-Deiry
TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death.
Cancer biology & therapy 2008;7(12):2034-8.
2008: Wensheng Yang; David T Dicker; Jiandong Chen; Wafik S El-Deiry
CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.
Cell cycle (Georgetown, Tex.) 2008;7(5):670-82.
2007: Elizabeth M Matthew; Tim J Yen; David T Dicker; Jay F Dorsey; Wensheng Yang; Arunasalam Navaraj; Wafik S El-Deiry
Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells.
Cell cycle (Georgetown, Tex.) 2007;6(20):2571-8.
2007: Raluca T Tavaluc; Lori S Hart; David T Dicker; Wafik S El-Deiry
Effects of low confluency, serum starvation and hypoxia on the side population of cancer cell lines.
Cell cycle (Georgetown, Tex.) 2007;6(20):2554-62.
2007: David T Dicker; Jeremy Lerner; Wafik S El-Deiry
Hyperspectral image analysis of live cells in various cell cycle stages.
Cell cycle (Georgetown, Tex.) 2007;6(20):2563-70.
2007: John P Plastaras; Seok-Hyun Kim; Yingqiu Y Liu; David T Dicker; Jay F Dorsey; James McDonough; george cerniglia; Ramji R Rajendran; Anjali Gupta; Anil K Rustgi; J Alan Diehl; Charles D Smith; Keith T Flaherty; Wafik S El-Deiry
Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation.
Cancer research 2007;67(19):9443-54.
2007: M Stacey Ricci; Seok-Hyun Kim; Kazuhiro Ogi; John P Plastaras; Jianhua Ling; Wenge Wang; Zhaoyu Jin; Yingqiu Y Liu; David T Dicker; Paul J Chiao; Keith T Flaherty; Charles D Smith; Wafik S El-Deiry
Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death.
Cancer cell 2007;12(1):66-80.
2007: Paul C Tumeh; Jeremy Lerner; David T Dicker; Wafik S El-Deiry
Differentiation of vascular and non-vascular skin spectral signatures using in vivo hyperspectral radiometric imaging: implications for monitoring angiogenesis.
Cancer biology & therapy 2007;6(3):447-53.
2007: Wensheng Yang; Laura M Rozan; E Robert McDonald; Arunasalam Navaraj; Jue Judy Liu; Elizabeth M Matthew; Wenge Wang; David T Dicker; Wafik S El-Deiry
CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.
The Journal of biological chemistry 2007;282(5):3273-81.
2006: David T Dicker; Jeremy Lerner; Patricia Van Belle; Stephen F Barth; DuPont Guerry; Meenhard Herlyn; David E Elder; Wafik S El-Deiry
Differentiation of normal skin and melanoma using high resolution hyperspectral imaging.
Cancer biology & therapy 2006;5(8):1033-8.
2005: Paul G Corn; M Stacey Ricci; Kimberly A Scata; Andrew M Arsham; M Celeste Simon; David T Dicker; Wafik S El-Deiry
Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis.
Cancer biology & therapy 2005;4(11):1285-94.
2005: Patrick A Mayes; Latoya Campbell; M Stacey Ricci; John P Plastaras; David T Dicker; Wafik S El-Deiry
Modulation of TRAIL-induced tumor cell apoptosis in a hypoxic environment.
Cancer biology & therapy 2005;4(10):1068-74.
2005: David T Dicker; Seok-Hyun Kim; Zhaoyu Jin; Wafik S El-Deiry
Heterogeneity in non-invasive detection of apoptosis among human tumor cell lines using annexin-V tagged with EGFP or Qdot-705.
Cancer biology & therapy 2005;4(9):1014-7.
2005: Wenge Wang; William C Ho; David T Dicker; Colin MacKinnon; Jeffrey D Winkler; Ronen Marmorstein; Wafik S El-Deiry
Acridine derivatives activate p53 and induce tumor cell death through Bax.
Cancer biology & therapy 2005;4(8):893-8.
2005: Jue Judy Liu; Wenge Wang; David T Dicker; Wafik S El-Deiry
Bioluminescent imaging of TRAIL-induced apoptosis through detection of caspase activation following cleavage of DEVD-aminoluciferin.
Cancer biology & therapy 2005;4(8):885-92.
2004: Peiwen Fei; Wenge Wang; Seok-hyun Kim; Shulin Wang; Timothy F Burns; Joanna K Sax; Monica Buzzai; David T Dicker; W Gillies McKenna; Eric J Bernhard; Wafik S El-Deiry
Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth.
Cancer cell 2004;6(6):597-609.
2004: M Stacey Ricci; Zhaoyu Jin; Michael Dews; Duonan Yu; Andrei Thomas-Tikhonenko; David T Dicker; Wafik S El-Deiry
Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.
Molecular and cellular biology 2004;24(19):8541-55.
2004: Seok-Hyun Kim; Kunhong Kim; Jae G Kwagh; David T Dicker; Meenhard Herlyn; Anil K Rustgi; Youhai Chen; Wafik S El-Deiry
Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells.
The Journal of biological chemistry 2004;279(38):40044-52.
2004: Zhaoyu Jin; E Robert McDonald; David T Dicker; Wafik S El-Deiry
Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis.
The Journal of biological chemistry 2004;279(34):35829-39.
2003: Timothy F Burns; Peiwen Fei; Kimberly A Scata; David T Dicker; Wafik S El-Deiry
Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells.
Molecular and cellular biology 2003;23(16):5556-71.
2003: David T Dicker; Wafik S El-Deiry
Flow cytometric analysis of tumor suppressor gene-induced apoptosis.
Methods in molecular biology (Clifton, N.J.) 2003;223():271-82.
2003: David T Dicker; Wafik S El-Deiry
Flow cytometric analysis of cell cycle control by tumor suppressor genes.
Methods in molecular biology (Clifton, N.J.) 2003;223():211-5.
2002: Rishu Takimoto; Timothy K MacLachlan; David T Dicker; Yoshiro Niitsu; Toshio Mori; Wafik S El-Deiry
BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation.
Cancer biology & therapy 2002;1(2):177-86.
2002: Joanna K Sax; Bipin C Dash; Rui Hong; David T Dicker; Wafik S El-Deiry
The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression).
Cell cycle (Georgetown, Tex.) 2002;1(1):90-6.
2002: Zhaoyu Jin; David T Dicker; Wafik S El-Deiry
Enhanced sensitivity of G1 arrested human cancer cells suggests a novel therapeutic strategy using a combination of simvastatin and TRAIL.
Cell cycle (Georgetown, Tex.) 2002;1(1):82-9.
2002: Rishu Takimoto; Wenge Wang; David T Dicker; Farzan Rastinejad; Joseph P Lyssikatos; Wafik S El-Deiry
The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein.
Cancer biology & therapy 2002;1(1):47-55.
2001: E Robert McDonald; Patricia C Chui; P F Martelli; David T Dicker; Wafik S El-Deiry
Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling.
The Journal of biological chemistry 2001;276(18):14939-45.
2001: Kunhong Kim; Rishu Takimoto; David T Dicker; Youhai Chen; Yair Gazitt; Wafik S El-Deiry
Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines.
International journal of oncology 2001;18(2):241-7.
2000: K O Mitchell; M Stacey Ricci; T Miyashita; David T Dicker; Zhaoyu Jin; J C Reed; Wafik S El-Deiry
Bax is a transcriptional target and mediator of c-myc-induced apoptosis.
Cancer research 2000;60(22):6318-25.
2000: N Ozoren; Kunhong Kim; Timothy F Burns; David T Dicker; A David Moscioni; Wafik S El-Deiry
The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand.
Cancer research 2000;60(22):6259-65.
2000: Timothy K MacLachlan; Bipin C Dash; David T Dicker; Wafik S El-Deiry
Repression of BRCA1 through a feedback loop involving p53.
The Journal of biological chemistry 2000;275(41):31869-75.
2000: Nesrin Ozören; M J Fisher; Kunhong Kim; CX Liu; Anna Genin; Y Shifman; David T Dicker; Nancy B Spinner; NA Lisitsyn; Wafik S El-Deiry
Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance.
International journal of oncology 2000;16(5):917-25.