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Ronald Dickinson

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Anatomy

Bile
Liver

Procedures

High Pressure Liquid Chromatography

Phenomena

Concepts & Ideas

Half-Life

Disorders

Epilepsy

Physiology

Biotransformation

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Co-Publications
Name
33
Hooper, WD
24
Eadie, Mervyn
8
Bernus, I
6
Addison, RS
5
Bailey, Mark
5
Cannell, Graeme
5
Verbeeck, Roger
5
Wang, Min
4
Worrall, Simon
3
Parker-Scott, SL
3
de Jersey, John
2
Fenselau, Catherine
2
Gillam, Elizabeth
2
Wright, Andrew
2
gorrell, mark

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Publications

TOP 3
Malone Stephen A; Eadie Mervyn J; Addison Russell S; Wright Andrew W E; Dickinson Ronald G
Monitoring salivary lamotrigine concentrations.
Matthias A; Addison R S; Penman K G; Dickinson R G; Bone K M; Lehmann R P
Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion.
Wright Andrew W E; Dickinson Ronald G
Abolition of valproate-derived choleresis in the Mrp2 transporter-deficient rat.

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All Publications

2006: Malone Stephen A; Eadie Mervyn J; Addison Russell S; Wright Andrew W E; Dickinson Ronald G
Monitoring salivary lamotrigine concentrations.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2006;13(9):902-7.
2005: Matthias A; Addison R S; Penman K G; Dickinson R G; Bone K M; Lehmann R P
Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion.
Life sciences 2005;77(16):2018-29.
2004: Wright Andrew W E; Dickinson Ronald G
Abolition of valproate-derived choleresis in the Mrp2 transporter-deficient rat.
The Journal of pharmacology and experimental therapeutics 2004;310(2):584-8.
2003: Bailey Mark J; Dickinson Ronald G
Acyl glucuronide reactivity in perspective: biological consequences.
Chemico-biological interactions 2003;145(2):117-37.
2002: Cannell Graeme R; Bailey Mark J; Dickinson Ronald G
Inhibition of tubulin assembly and covalent binding to microtubular protein by valproic acid glucuronide in vitro.
Life sciences 2002;71(22):2633-43.
2002: Jaggi R; Addison R S; King A R; Suthers B D; Dickinson R G
Conjugation of desmethylnaproxen in the rat--a novel acyl glucuronide-sulfate diconjugate as a major biliary metabolite.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(2):161-6.
2002: Wang Min; Gorrell Mark D; Abbott Catherine A; Jaggi Rene; Marguet Didier; Dickinson Ronald G
Hepatic covalent adduct formation with zomepirac in the CD26-deficient mouse.
Journal of gastroenterology and hepatology 2002;17(1):66-71.
2001: Cannell G R; Vesey D A; Dickinson R G
Inhibition of proliferation of HT-29 colon adenocarcinoma cells by carboxylate NSAIDs and their acyl glucuronides.
Life sciences 2001;70(1):37-48.
2001: Dickinson R G; King A R
Rearrangement of diflunisal acyl glucuronide into its beta-glucuronidase-resistant isomers facilitates transport through the small intestine to the colon of the rat.
Life sciences 2001;70(1):25-36.
2001: Lo A; Addison R S; Hooper W D; Dickinson R G
Disposition of naproxen, naproxen acyl glucuronide and its rearrangement isomers in the isolated perfused rat liver.
Xenobiotica; the fate of foreign compounds in biological systems 2001;31(6):309-19.
2001: Wang M; Gorrell M D; McGaughan G W; Dickinson R G
Dipeptidyl peptidase IV is a target for covalent adduct formation with the acyl glucuronide metabolite of the anti-inflammatory drug zomepirac.
Life sciences 2001;68(7):785-97.
2000: Addison R S; Parker-Scott S L; Eadie M J; Hooper W D; Dickinson R G
Steady-state dispositions of valproate and diflunisal alone and coadministered to healthy volunteers.
European journal of clinical pharmacology 2000;56(9-10):715-21.
2000: Wang M; Dickinson R G
Bile duct ligation promotes covalent drug-protein adduct formation in plasma but not in liver of rats given zomepirac.
Life sciences 2000;68(5):525-37.
2000: McLaughlin D B; Eadie M J; Parker-Scott S L; Addison R S; Henderson R D; Hooper W D; Dickinson R G
Valproate metabolism during valproate-associated hepatotoxicity in a surviving adult patient.
Epilepsy research 2000;41(3):259-68.
2000: Addison R S; Parker-Scott S L; Hooper W D; Eadie M J; Dickinson R G
Effect of naproxen co-administration on valproate disposition.
Biopharmaceutics & drug disposition 2000;21(6):235-42.
2000: Cuttle L; Munns A J; Hogg N A; Scott J R; Hooper W D; Dickinson R G; Gillam E M
Phenytoin metabolism by human cytochrome P450: involvement of P450 3A and 2C forms in secondary metabolism and drug-protein adduct formation.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(8):945-50.
2000: McLaughlin D B; Andrews J A; Hooper W D; Cannell G R; Eadie M J; Dickinson R G
Apparent autoinduction of valproate beta-oxidation in humans.
British journal of clinical pharmacology 2000;49(5):409-15.
2000: Jacob S S; Franklin M E; Dickinson R G; Hooper W D
The effect of diflunisal on the elimination of triamterene in human volunteers.
Drug metabolism and drug interactions 2000;16(3):159-71.
1999: Bailey M J; Dickinson R G
Limitations of hepatocytes and liver homogenates in modelling in vivo formation of acyl glucuronide-derived drug-protein adducts.
Journal of pharmacological and toxicological methods 1999;41(1):27-32.
1998: Bailey M J; Worrall S; de Jersey J; Dickinson R G
Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system.
Chemico-biological interactions 1998;115(2):153-66.
1998: Wang M; Dickinson R G
Disposition and covalent binding of diflunisal and diflunisal acyl glucuronide in the isolated perfused rat liver.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(2):98-104.
1998: Wang M; Dickinson R G
Hepatobiliary transport of diflunisal conjugates and taurocholate by the perfused rat liver: the effect of chronic exposure of rats to diflunisal.
Life sciences 1998;62(8):751-62.
1997: Munns A J; De Voss J J; Hooper W D; Dickinson R G; Gillam E M
Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation.
Chemical research in toxicology 1997;10(9):1049-58.
1997: Bernus I; Dickinson R G; Hooper W D; Eadie M J
The mechanism of the carbamazepine-valproate interaction in humans.
British journal of clinical pharmacology 1997;44(1):21-7.
1997: Bernus I; Dickinson R G; Hooper W D; Eadie M J
Anticonvulsant therapy in aged patients. Clinical pharmacokinetic considerations.
Drugs & aging 1997;10(4):278-89.
1997: Bernus I; Hooper W D; Dickinson R G; Eadie M J
Effects of pregnancy on various pathways of human antiepileptic drug metabolism.
Clinical neuropharmacology 1997;20(1):13-21.
1996: King A R; Dickinson R G
The utility of the bile-exteriorized rat as a source of reactive acyl glucuronides: studies with zomepirac.
Journal of pharmacological and toxicological methods 1996;36(3):131-6.
1996: Dickinson R G; King A R
Vesico-hepato-renal cycling of acidic drugs via their reactive acyl glucuronide metabolites? Studies with diflunisal in rats.
Clinical and experimental pharmacology & physiology 1996;23(8):665-8.
1996: Bernus I; Dickinson R G; Hooper W D; Eadie M J
Dose-dependent metabolism of carbamazepine in humans.
Epilepsy research 1996;24(3):163-72.
1996: Bailey M J; Dickinson R G
Chemical and immunochemical comparison of protein adduct formation of four carboxylate drugs in rat liver and plasma.
Chemical research in toxicology 1996;9(3):659-66.
1996: Hooper W D; Franklin M E; Glue P; Banfield C R; Radwanski E; McLaughlin D B; McIntyre M E; Dickinson R G; Eadie M J
Effect of felbamate on valproic acid disposition in healthy volunteers: inhibition of beta-oxidation.
Epilepsia 1996;37(1):91-7.
1995: Bernus I; Hooper W D; Dickinson R G; Eadie M J
Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy.
Epilepsy research 1995;21(1):65-75.
1995: Williams A M; Worrall S; De Jersey J; Dickinson R G
Studies on the reactivity of acyl glucuronides--VIII. Generation of an antiserum for the detection of diflunisal-modified proteins in diflunisal-dosed rats.
Biochemical pharmacology 1995;49(2):209-17.
1995: Shore L J; Fenselau C; King A R; Dickinson R G
Characterization and formation of the glutathione conjugate of clofibric acid.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(1):119-23.
1995: Worrall S; Dickinson R G
Rat serum albumin modified by diflunisal acyl glucuronide is immunogenic in rats.
Life sciences 1995;56(22):1921-30.
1994: Bernus I; Dickinson R G; Hooper W D; Eadie M J
Inhibition of phenobarbitone N-glucosidation by valproate.
British journal of clinical pharmacology 1994;38(5):411-6.
1994: Dickinson R G; King A R; Kelly M A; Kaltashov I A; Fenselau C
Excretion of 3-hydroxy-diflunisal as a monosulphate conjugate--identification using ESI-MS.
Journal of pharmaceutical and biomedical analysis 1994;12(9):1075-8.
1994: Dickinson R G; Baker P V; King A R
Studies on the reactivity of acyl glucuronides--VII. Salicyl acyl glucuronide reactivity in vitro and covalent binding of salicylic acid to plasma protein of humans taking aspirin.
Biochemical pharmacology 1994;47(3):469-76.
1994: Williams A M; Dickinson R G
Studies on the reactivity of acyl glucuronides--VI. Modulation of reversible and covalent interaction of diflunisal acyl glucuronide and its isomers with human plasma protein in vitro.
Biochemical pharmacology 1994;47(3):457-67.
1994: Bernus I; Dickinson R G; Hooper W D; Eadie M J
Urinary excretion of phenobarbitone and its metabolites in chronically treated patients.
European journal of clinical pharmacology 1994;46(5):473-5.
1994: Bernus I; Dickinson R G; Hooper W D; Eadie M J
Early stage autoinduction of carbamazepine metabolism in humans.
European journal of clinical pharmacology 1994;47(4):355-60.
1993: Dickinson R G; King A R
Studies on the reactivity of acyl glucuronides--V. Glucuronide-derived covalent binding of diflunisal to bladder tissue of rats and its modulation by urinary pH and beta-glucuronidase.
Biochemical pharmacology 1993;46(7):1175-82.
1993: Dickinson R G; King A R; McKinnon G E; Hooper W D; Eadie M J; Herkes G K
Studies on the renal excretion of the acyl glucuronide, phenolic glucuronide and sulphate conjugates of diflunisal.
British journal of clinical pharmacology 1993;35(6):609-13.
1993: King A R; Dickinson R G
Studies on the reactivity of acyl glucuronides--IV. Covalent binding of diflunisal to tissues of the rat.
Biochemical pharmacology 1993;45(5):1043-7.
1993: Dickinson R G
Acyl glucuronide conjugates: reactive metabolites of non-steroidal anti-inflammatory drugs.
Proceedings of the Western Pharmacology Society 1993;36():157-62.
1992: Williams A M; Worrall S; de Jersey J; Dickinson R G
Studies on the reactivity of acyl glucuronides--III. Glucuronide-derived adducts of valproic acid and plasma protein and anti-adduct antibodies in humans.
Biochemical pharmacology 1992;43(4):745-55.
1992: Eadie M J; McKinnon G E; Dickinson R G; Hooper W D; Lander C M
Phenytoin metabolism during pregnancy.
European journal of clinical pharmacology 1992;43(4):389-92.
1991: Dickinson R G; King A R
Studies on the reactivity of acyl glucuronides--II. Interaction of diflunisal acyl glucuronide and its isomers with human serum albumin in vitro.
Biochemical pharmacology 1991;42(12):2301-6.
1991: King A R; Dickinson R G
Studies on the reactivity of acyl glucuronides--I. Phenolic glucuronidation of isomers of diflunisal acyl glucuronide in the rat.
Biochemical pharmacology 1991;42(12):2289-99.
1991: Dickinson R G; Verbeeck R K; King A R
Absence of phenolic glucuronidation and enhanced hydroxylation of diflunisal in the homozygous Gunn rat.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(11):1535-46.
1991: Macdonald J I; Dickinson R G; Reid R S; Edom R W; King A R; Verbeeck R K
Identification of a hydroxy metabolite of diflunisal in rat and human urine.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(11):1521-33.
1991: Dickinson R G; Baker P V; Franklin M E; Hooper W D
Facile hydrolysis of mebeverine in vitro and in vivo: negligible circulating concentrations of the drug after oral administration.
Journal of pharmaceutical sciences 1991;80(10):952-7.
1991: Dickinson R G; King A R; Hansen-Møller J
The sulphate conjugate of diflunisal: its synthesis and systemic stability in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(5):635-40.
1991: Dickinson R G; Verbeeck R K; King A R; Restifo A C; Pond S M
Diflunisal and its conjugates in patients with renal failure.
British journal of clinical pharmacology 1991;31(5):546-50.
1991: Watt J A; King A R; Dickinson R G
Contrasting systemic stabilities of the acyl and phenolic glucuronides of diflunisal in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(3):403-15.
1990: Eadie M J; McKinnon G E; Dunstan P R; MacLaughlin D; Dickinson R G
Valproate metabolism during hepatotoxicity associated with the drug.
The Quarterly journal of medicine 1990;77(284):1229-40.
1990: Watt J A; Dickinson R G
Effects of blockage of urine and/or bile flow on diflunisal conjugation and disposition in rats.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(8):835-45.
1990: Watt J A; Dickinson R G
The effect of diethyl ether, pentobarbitone and urethane anaesthesia on diflunisal conjugation and disposition in rats.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(3):289-301.
1990: Watt J A; Dickinson R G
Reactivity of diflunisal acyl glucuronide in human and rat plasma and albumin solutions.
Biochemical pharmacology 1990;39(6):1067-75.
1989: Dickinson R G; King A R; Verbeeck R K
Elimination of diflunisal as its acyl glucuronide, phenolic glucuronide and sulfate conjugates in bile-exteriorized and intact rats.
Clinical and experimental pharmacology & physiology 1989;16(12):913-24.
1989: McKinnon G E; Dickinson R G
Covalent binding of diflunisal and probenecid to plasma protein in humans: persistence of the adducts in the circulation.
Research communications in chemical pathology and pharmacology 1989;66(3):339-54.
1989: Dickinson R G; King A R
Reactivity considerations in the analysis of glucuronide and sulfate conjugates of diflunisal.
Therapeutic drug monitoring 1989;11(6):712-20.
1989: Dickinson R G; Fowler D W; Kluck R M
Maternofetal transfer of phenytoin, p-hydroxy-phenytoin and p-hydroxy-phenytoin-glucuronide in the perfused human placenta.
Clinical and experimental pharmacology & physiology 1989;16(10):789-97.
1989: Dickinson R G; Hooper W D; Wood B; Lander C M; Eadie M J
The effect of pregnancy in humans on the pharmacokinetics of stable isotope labelled phenytoin.
British journal of clinical pharmacology 1989;28(1):17-27.
1989: Fowler D W; Eadie M J; Dickinson R G
Transplacental transfer and biotransformation studies of valproic acid and its glucuronide(s) in the perfused human placenta.
The Journal of pharmacology and experimental therapeutics 1989;249(1):318-23.
1989: Dickinson R G; Hooper W D; Dunstan P R; Eadie M J
First dose and steady-state pharmacokinetics of oxcarbazepine and its 10-hydroxy metabolite.
European journal of clinical pharmacology 1989;37(1):69-74.
1989: Dickinson R G; Hooper W D; Dunstan P R; Eadie M J
Urinary excretion of valproate and some metabolites in chronically treated patients.
Therapeutic drug monitoring 1989;11(2):127-33.
1988: Cannell G R; Kluck R M; Hamilton S E; Mortimer R H; Hooper W D; Dickinson R G
Markers of physical integrity and metabolic viability of the perfused human placental lobule.
Clinical and experimental pharmacology & physiology 1988;15(11):837-44.
1988: Kluck R M; Cannell G R; Hooper W D; Eadie M J; Dickinson R G
Disposition of phenytoin and phenobarbitone in the isolated perfused human placenta.
Clinical and experimental pharmacology & physiology 1988;15(11):827-36.
1988: Verbeeck R K; Dickinson R G; Pond S M
Biliary excretion of diflunisal conjugates in patients with T-tube drainage.
European journal of clinical pharmacology 1988;34(4):423-6.
1988: Dickinson R G; Hooper W D; Pendlebury S C; Moses D; Eadie M J
Further clinical and pharmacokinetic observations on the new anticonvulsant, oxcarbazepine.
Clinical and experimental neurology 1988;25():127-33.
1987: Hooper W D; Dickinson R G; Dunstan P R; Pendlebury S C; Eadie M J
Oxcarbazepine: preliminary clinical and pharmacokinetic studies on a new anticonvulsant.
Clinical and experimental neurology 1987;24():105-12.
1986: Dickinson R G; Kluck R M; Wood B T; Eadie M J; Hooper W D
Impaired biliary elimination of beta-glucuronidase-resistant "glucuronides" of valproic acid after intravenous administration in the rat. Evidence for oxidative metabolism of the resistant isomers.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(2):255-62.
1986: Dickinson R G; Wood B T; Kluck R M; Hooper W D
"Radiochemically pure [1-14C]valproic acid"--a mixture of labeled structural isomers.
Therapeutic drug monitoring 1986;8(4):462-5.
1985: Dickinson R G; Kluck R M; Hooper W D; Patterson M; Chalk J B; Eadie M J
Rearrangement of valproate glucuronide in a patient with drug-associated hepatobiliary and renal dysfunction.
Epilepsia 1985;26(6):589-93.
1985: Dickinson R G; Kluck R M; Eadie M J; Hooper W D
Disposition of beta-glucuronidase-resistant "glucuronides" of valproic acid after intrabiliary administration in the rat: intact absorption, fecal excretion and intestinal hydrolysis.
The Journal of pharmacology and experimental therapeutics 1985;233(1):214-21.
1985: Dickinson R G; Hooper W D; King A R; Eadie M J
Fallacious results from measuring salivary carbamazepine concentrations.
Therapeutic drug monitoring 1985;7(1):41-5.
1985: Hooper W D; King A R; Patterson M; Dickinson R G; Eadie M J
Simultaneous plasma carbamazepine and carbamazepine-epoxide concentrations in pharmacokinetic and bioavailability studies.
Therapeutic drug monitoring 1985;7(1):36-40.

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