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Patrick Diel

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Almut F Molzberger; Sebastian T Soukup; Sabine E Kulling; Patrick Diel
Proliferative and estrogenic sensitivity of the mammary gland are modulated by isoflavones during distinct periods of adolescence.
Felix M Kluxen; Eugenia Becker; Patrick Diel; Nicola Höfer; Gisela H Degen
The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol.
Frank Josef Möller; Oliver Zierau; Gisela H Degen; Patrick Diel; Torsten Hertrampf; Corinna Ledwig; Günter Vollmer
The rat prepubertal uterine myometrium and not the luminal epithelium is predominantly affected by a chronic dietary genistein exposure.

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2013: Almut F Molzberger; Sebastian T Soukup; Sabine E Kulling; Patrick Diel
Proliferative and estrogenic sensitivity of the mammary gland are modulated by isoflavones during distinct periods of adolescence.
Archives of toxicology 2013;87(6):1129-40.
2013: Felix M Kluxen; Eugenia Becker; Patrick Diel; Nicola Höfer; Gisela H Degen
The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol.
Archives of toxicology 2013;87(4):633-43.
2012: Frank Josef Möller; Oliver Zierau; Gisela H Degen; Patrick Diel; Torsten Hertrampf; Corinna Ledwig; Günter Vollmer
The rat prepubertal uterine myometrium and not the luminal epithelium is predominantly affected by a chronic dietary genistein exposure.
Archives of toxicology 2012;86(12):1899-910.
2012: Felicitas Rataj; Günter Vollmer; Oliver Zierau; Patrick Diel; Maria Jähne; Frank Josef Möller; Georg Kretzschmar
Regulation of uterine AHR battery gene expression by 17β-Estradiol is predominantly mediated by estrogen receptor α.
Archives of toxicology 2012;86(10):1603-12.
2012: Nora Zoth; Michael Kalicinski; Marion Piechotta; Oliver Selder; Nadine Selke; Carmen Weigt; Sinan Zengin; Patrick Diel
Metabolic effects of estrogen substitution in combination with targeted exercise training on the therapy of obesity in ovariectomized Wistar rats.
The Journal of steroid biochemistry and molecular biology 2012;130(1-2):64-72.
2012: Martina Velders; Oliver Zierau; Karl-Heinrich Fritzemeier; Burkhardt Schleipen; Patrick Diel
Selective estrogen receptor-β activation stimulates skeletal muscle growth and regeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(5):1909-20.
2012: Carmen Weigt; Nora Zoth; Karl-Heinrich Fritzemeier; Torsten Hertrampf; Patrick Diel
Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity.
Molecular and cellular endocrinology 2012;351(2):227-38.
2012: Felix M Kluxen; Georg Kretzschmar; Gisela H Degen; Nicola Höfer; Patrick Diel
Cadmium modulates expression of aryl hydrocarbon receptor-associated genes in rat uterus by interaction with the estrogen receptor.
Archives of toxicology 2012;86(4):591-601.
2012: Almut F Molzberger; Günter Vollmer; Torsten Hertrampf; Sabine Kulling; Frank Josef Möller; Patrick Diel
In utero and postnatal exposure to isoflavones results in a reduced responsivity of the mammary gland towards estradiol.
Molecular nutrition & food research 2012;56(3):399-409.
2011: Maria K Parr; Wilhelm Schänzer; Oliver Zierau; Christina Blatt; Gregor Fusshöller; Michael Gütschow; Cornelius Hess; Georg Opfermann; Patrick Diel
Endocrine characterization of the designer steroid methyl-1-testosterone: investigations on tissue-specific anabolic-androgenic potency, side effects, and metabolism.
Endocrinology 2011;152(12):4718-28.
2011: B Schleipen; M Velders; Karl-Heinrich Fritzemeier; Torsten Hertrampf; F M Kluxen; A Lorenz; A Molzberger; Patrick Diel
ERβ-specific agonists and genistein inhibit proliferation and induce apoptosis in the large and small intestine.
Carcinogenesis 2011;32(11):1675-83.
2011: S Frese; M Velders; B Schleipen; Wilhelm Schänzer; Wilhelm Bloch; Patrick Diel
Myosin heavy chain expression pattern as a marker for anabolic potency: desoxymethyltestosterone (madol), norandrostenedione and testosterone repress MHC-IIb expression and stimulate MHC-IId/x expression in orchiectomized rat gastrocnemius muscle.
Archives of toxicology 2011;85(6):635-43.
2011: Sylvi Wolf; Patrick Diel; Maria Kristina Parr; Felicitas Rataj; Willhelm Schänzer; Günter Vollmer; Oliver Zierau
Long-term detection of methyltestosterone (ab-) use by a yeast transactivation system.
Archives of toxicology 2011;85(4):285-92.
2010: Sylvi Wolf; Felicitas Rataj; Oliver Zierau; Kai Ostermann; Patrick Diel; Maria Kristina Parr; Günter Vollmer; Gerhard Rödel
A novel combined approach to detect androgenic activities with yeast based assays in Schizosaccharomyces pombe and Saccharomyces cerevisiae.
Toxicology letters 2010;199(3):410-5.
2010: Patrick Diel; Thorsten Schiffer; Stephan Geisler; Torsten Hertrampf; Stephanie Mosler; Sven Schulz; Karl Florian Wintgens; Michael Adler
Analysis of the effects of androgens and training on myostatin propeptide and follistatin concentrations in blood and skeletal muscle using highly sensitive immuno PCR.
Molecular and cellular endocrinology 2010;330(1-2):1-9.
2010: Nora Zoth; Carmen Weigt; Ute Laudenbach-Leschowski; Patrick Diel
Physical activity and estrogen treatment reduce visceral body fat and serum levels of leptin in an additive manner in a diet induced animal model of obesity.
The Journal of steroid biochemistry and molecular biology 2010;122(1-3):100-5.
2010: Frank Josef Möller; Patrick Diel; Oliver Zierau; Torsten Hertrampf; Juliane Maass; Günter Vollmer
Long-term dietary isoflavone exposure enhances estrogen sensitivity of rat uterine responsiveness mediated through estrogen receptor alpha.
Toxicology letters 2010;196(3):142-53.
2010: Nicola Höfer; Patrick Diel; Jürgen Wittsiepe; Michael Wilhelm; Felix M Kluxen; Gisela H Degen
Investigations on the estrogenic activity of the metallohormone cadmium in the rat intestine.
Archives of toxicology 2010;84(7):541-52.
2010: M Velders; M Solzbacher; B Schleipen; U Laudenbach; Karl-Heinrich Fritzemeier; Patrick Diel
Estradiol and genistein antagonize the ovariectomy effects on skeletal muscle myosin heavy chain expression via ER-beta mediated pathways.
The Journal of steroid biochemistry and molecular biology 2010;120(1):53-9.
2009: Torsten Hertrampf; C Ledwig; S Kulling; A Molzberger; F J Möller; Oliver Zierau; Günter Vollmer; S Moors; Gisela H Degen; Patrick Diel
Responses of estrogen sensitive tissues in female Wistar rats to pre- and postnatal isoflavone exposure.
Toxicology letters 2009;191(2-3):181-8.
2009: Nicola Höfer; Patrick Diel; Jürgen Wittsiepe; Michael Wilhelm; Gisela H Degen
Dose- and route-dependent hormonal activity of the metalloestrogen cadmium in the rat uterus.
Toxicology letters 2009;191(2-3):123-31.
2009: Maria K Parr; Ute Laudenbach-Leschowsky; Nicola Höfer; Wilhelm Schänzer; Patrick Diel
Anabolic and androgenic activity of 19-norandrostenedione after oral and subcutaneous administration--analysis of side effects and metabolism.
Toxicology letters 2009;188(2):137-41.
2009: Jan Seibel; Almut F Molzberger; Torsten Hertrampf; Ute Laudenbach-Leschowski; Patrick Diel
Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis.
European journal of nutrition 2009;48(4):213-20.
2009: Torsten Hertrampf; B Schleipen; C Offermanns; M Velders; U Laudenbach; Patrick Diel
Comparison of the bone protective effects of an isoflavone-rich diet with dietary and subcutaneous administrations of genistein in ovariectomized rats.
Toxicology letters 2009;184(3):198-203.
2009: Frank Josef Möller; Oliver Zierau; Torsten Hertrampf; Anja Bliedtner; Patrick Diel; Günter Vollmer
Long-term effects of dietary isoflavones on uterine gene expression profiles.
The Journal of steroid biochemistry and molecular biology 2009;113(3-5):296-303.
2008: Susanne B Dorn; Hermann M Bolt; Mario Thevis; Patrick Diel; Gisela H Degen
Micronucleus induction in V79 cells by the anabolic doping steroids desoxymethyltestosterone (madol) and 19-norandrostenedione.
Toxicology letters 2008;183(1-3):58-64.
2008: Jan Seibel; Almut F Molzberger; Torsten Hertrampf; Ute Laudenbach-Leschowski; Gisela H Degen; Patrick Diel
In utero and postnatal exposure to a phytoestrogen-enriched diet increases parameters of acute inflammation in a rat model of TNBS-induced colitis.
Archives of toxicology 2008;82(12):941-50.
2008: Oliver Zierau; Sylvi Lehmann; Günter Vollmer; Wilhelm Schänzer; Patrick Diel
Detection of anabolic steroid abuse using a yeast transactivation system.
Steroids 2008;73(11):1143-7.
2008: Torsten Hertrampf; B Schleipen; M Velders; U Laudenbach; Karl-Heinrich Fritzemeier; Patrick Diel
Estrogen receptor subtype-specific effects on markers of bone homeostasis.
Molecular and cellular endocrinology 2008;291(1-2):104-8.
2008: Patrick Diel; D Baadners; K Schlüpmann; M Velders; J P Schwarz
C2C12 myoblastoma cell differentiation and proliferation is stimulated by androgens and associated with a modulation of myostatin and Pax7 expression.
Journal of molecular endocrinology 2008;40(5):231-41.
2008: Patrick Diel; Angelika Friedel; Hans Geyer; Matthias Kamber; Ute Laudenbach-Leschowsky; Wilhelm Schänzer; B Schleipen; Mario Thevis; Günter Vollmer; Oliver Zierau
The prohormone 19-norandrostenedione displays selective androgen receptor modulator (SARM) like properties after subcutaneous administration.
Toxicology letters 2008;177(3):198-204.
2008: Torsten Hertrampf; Jan Seibel; U Laudenbach; Karl-Heinrich Fritzemeier; Patrick Diel
Analysis of the effects of oestrogen receptor alpha (ERalpha)- and ERbeta-selective ligands given in combination to ovariectomized rats.
British journal of pharmacology 2008;153(7):1432-7.
2008: Susanne B Dorn; Hermann M Bolt; Mario Thevis; Patrick Diel; Gisela H Degen
Induction of micronuclei in V79 cells by the anabolic doping steroids tetrahydrogestrinone and trenbolone.
Archives of toxicology 2008;82(4):257-63.
2007: M Dworak; Patrick Diel; Sven Christian Voss; Wildor Hollmann; Heiko K Strüder
Intense exercise increases adenosine concentrations in rat brain: implications for a homeostatic sleep drive.
Neuroscience 2007;150(4):789-95.
2007: Torsten Hertrampf; M J Gruca; Jan Seibel; U Laudenbach; Karl-Heinrich Fritzemeier; Patrick Diel
The bone-protective effect of the phytoestrogen genistein is mediated via ER alpha-dependent mechanisms and strongly enhanced by physical activity.
Bone 2007;40(6):1529-35.
2007: Patrick Diel; Angelika Friedel; Hans Geyer; Matthias Kamber; Ute Laudenbach-Leschowsky; Wilhelm Schänzer; Mario Thevis; Günter Vollmer; Oliver Zierau
Characterisation of the pharmacological profile of desoxymethyltestosterone (Madol), a steroid misused for doping.
Toxicology letters 2007;169(1):64-71.
2006: Patrick Diel; Torsten Hertrampf; Jan Seibel; Ute Laudenbach-Leschowsky; Susanne Kolba; Günter Vollmer
Combinatorial effects of the phytoestrogen genistein and of estradiol in uterus and liver of female Wistar rats.
The Journal of steroid biochemistry and molecular biology 2006;102(1-5):60-70.
2006: Simone Schmidt; Gisela H Degen; Jan Seibel; Torsten Hertrampf; Günter Vollmer; Patrick Diel
Hormonal activity of combinations of genistein, bisphenol A and 17beta-estradiol in the female Wistar rat.
Archives of toxicology 2006;80(12):839-45.
2006: Stefan Moors; Patrick Diel; Gisela H Degen
Toxicokinetics of bisphenol A in pregnant DA/Han rats after single i.v. application.
Archives of toxicology 2006;80(10):647-55.
2006: Angelika Friedel; Hans Geyer; Matthias Kamber; Ute Laudenbach-Leschowsky; Wilhelm Schänzer; Mario Thevis; Günter Vollmer; Oliver Zierau; Patrick Diel
17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties.
Toxicology letters 2006;165(2):149-55.
2006: Angelika Friedel; Hans Geyer; Matthias Kamber; Ute Laudenbach-Leschowsky; Wilhelm Schänzer; Mario Thevis; Günter Vollmer; Oliver Zierau; Patrick Diel
Tetrahydrogestrinone is a potent but unselective binding steroid and affects glucocorticoid signalling in the liver.
Toxicology letters 2006;164(1):16-23.
2006: Torsten Hertrampf; Gisela H Degen; Abdel Ait Kaid; Ute Laudenbach-Leschowsky; Jan Seibel; Ana Laura Di Virgilio; Patrick Diel
Combined effects of physical activity, dietary isoflavones and 17beta-estradiol on movement drive, body weight and bone mineral density in ovariectomized female rats.
Planta medica 2006;72(6):484-7.
2006: Torsten Hertrampf; Simone Schmidt; Jan Seibel; Ute Laudenbach-Leschowsky; Gisela H Degen; Patrick Diel
Effects of genistein on the mammary gland proliferation of adult ovariectomised Wistar rats.
Planta medica 2006;72(4):304-10.
2006: Oliver Zierau; Susanne Kolba; Sabine Olff; Günter Vollmer; Patrick Diel
Analysis of the promoter-specific estrogenic potency of the phytoestrogens genistein, daidzein and coumestrol.
Planta medica 2006;72(2):184-6.
2005: Torsten Hertrampf; Simone Schmidt; Ute Laudenbach-Leschowsky; Jan Seibel; Patrick Diel
Tissue-specific modulation of cyclooxygenase-2 (Cox-2) expression in the uterus and the v. cava by estrogens and phytoestrogens.
Molecular and cellular endocrinology 2005;243(1-2):51-7.
2005: Antonio Caldarelli; Patrick Diel; Günter Vollmer
Effect of phytoestrogens on gene expression of carbonic anhydrase II in rat uterus and liver.
The Journal of steroid biochemistry and molecular biology 2005;97(3):251-6.
2005: Renate-B Geis; Patrick Diel; Gisela H Degen; Günter Vollmer
Effects of genistein on the expression of hepatic genes in two rat strains (Sprague-Dawley and Wistar).
Toxicology letters 2005;157(1):21-9.
2005: Simone Schmidt; Horst Michna; Patrick Diel
Combinatory effects of phytoestrogens and 17beta-estradiol on proliferation and apoptosis in MCF-7 breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2005;94(5):445-9.
2005: Antonis Matsakas; Angelika Friedel; Torsten Hertrampf; Patrick Diel
Short-term endurance training results in a muscle-specific decrease of myostatin mRNA content in the rat.
Acta physiologica Scandinavica 2005;183(3):299-307.
2005: Antonis Matsakas; Patrick Diel
The growth factor myostatin, a key regulator in skeletal muscle growth and homeostasis.
International journal of sports medicine 2005;26(2):83-9.
2005: Patrick Diel; Ute Laudenbach-Leschowsky; Angelika Friedel; Anika Voss; Jérôme Roussel
Pulsed estradiol exposure has a limited ability to induce uterine proliferation in ovariectomised female Wistar rats.
Molecular and cellular endocrinology 2005;230(1-2):7-15.
2004: Antonis Matsakas; Michalis G Nikolaidis; Nikos Kokalas; Vassilis Mougios; Patrick Diel
Effect of voluntary exercise on the expression of IGF-I and androgen receptor in three rat skeletal muscles and on serum IGF-I and testosterone levels.
International journal of sports medicine 2004;25(7):502-8.
2004: Patrick Diel; Renate-B Geis; Antonio Caldarelli; Simone Schmidt; Ute Laudenbach Leschowsky; Anika Voss; Günter Vollmer
The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and proliferation in the rat is associated with a substance specific modulation of uterine gene expression.
Molecular and cellular endocrinology 2004;221(1-2):21-32.
2004: Patrick Diel; Simone Schmidt; Günter Vollmer; Petra Janning; Andreas Upmeier; Horst Michna; Hermann M Bolt; Gisela H Degen
Comparative responses of three rat strains (DA/Han, Sprague-Dawley and Wistar) to treatment with environmental estrogens.
Archives of toxicology 2004;78(4):183-93.
2004: Patrick Diel; Renate B Thomae; Antonio Caldarelli; Oliver Zierau; Susanne Kolba; Simone Schmidt; Pia Schwab; Peter Metz; Günter Vollmer
Regulation of gene expression by 8-prenylnaringenin in uterus and liver of Wistar rats.
Planta medica 2004;70(1):39-44.
2002: Patrick Diel; Simone Schmidt; Günter Vollmer
In vivo test systems for the quantitative and qualitative analysis of the biological activity of phytoestrogens.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;777(1-2):191-202.
2002: Gisela H Degen; Petra Janning; Patrick Diel; Hermann M Bolt
Estrogenic isoflavones in rodent diets.
Toxicology letters 2002;128(1-3):145-57.
2002: Patrick Diel
Tissue-specific estrogenic response and molecular mechanisms.
Toxicology letters 2002;127(1-3):217-24.
2002: Gisela H Degen; Petra Janning; Patrick Diel; Horst Michna; Hermann M Bolt
Transplacental transfer of the phytoestrogen daidzein in DA/Han rats.
Archives of toxicology 2002;76(1):23-9.
2002: Patrick Diel; Sabine Olff; Simone Schmidt; Horst Michna
Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7.
The Journal of steroid biochemistry and molecular biology 2002;80(1):61-70.
2001: Patrick Diel; Sabine Olff; Simone Schmidt; Horst Michna
Molecular identification of potential selective estrogen receptor modulator (SERM) like properties of phytoestrogens in the human breast cancer cell line MCF-7.
Planta medica 2001;67(6):510-4.
2001: Patrick Diel; K Smolnikar; T Schulz; U Laudenbach-Leschowski; Horst Michna; Günter Vollmer
Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium.
Human reproduction (Oxford, England) 2001;16(5):997-1006.
2000: K Smolnikar; S Löffek; T Schulz; Horst Michna; Patrick Diel
Treatment with the pure antiestrogen faslodex (ICI 182780) induces tumor necrosis factor receptor 1 (TNFR1) expression in MCF-7 breast cancer cells.
Breast cancer research and treatment 2000;63(3):249-59.
2000: Andreas Upmeier; Gisela H Degen; Patrick Diel; Horst Michna; Hermann M Bolt
Toxicokinetics of bisphenol A in female DA/Han rats after a single i.v. and oral administration.
Archives of toxicology 2000;74(8):431-6.
2000: Petra Janning; US Schuhmacher; Andreas Upmeier; Patrick Diel; Horst Michna; Gisela H Degen; Hermann M Bolt
Toxicokinetics of the phytoestrogen daidzein in female DA/Han rats.
Archives of toxicology 2000;74(8):421-30.
2000: Patrick Diel; T Schulz; K Smolnikar; Elisabeth Strunck; Günter Vollmer; Horst Michna
Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity.
The Journal of steroid biochemistry and molecular biology 2000;73(1-2):1-10.
1999: Patrick Diel; K Smolnikar; Horst Michna
The pure antiestrogen ICI 182780 is more effective in the induction of apoptosis and down regulation of BCL-2 than tamoxifen in MCF-7 cells.
Breast cancer research and treatment 1999;58(2):87-97.
1999: Patrick Diel; K Smolnikar; Horst Michna
In vitro test systems for the evaluation of the estrogenic activity of natural products.
Planta medica 1999;65(3):197-203.
1997: Christa Hegele-Hartung; Karl-Heinrich Fritzemeier; Patrick Diel
Effects of a pure antiestrogen and progesterone on estrogen-mediated alterations of blood flow and progesterone receptor expression in the aorta of ovariectomized rabbits.
The Journal of steroid biochemistry and molecular biology 1997;63(4-6):237-49.