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John Dietschy

Research Profile

Chemicals & Drugs

Anatomy

Livers

Living Beings

Disorders

Niemann-Pick Diseases

Physiology

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Publications

TOP 3
Ryan D Jones; Joyce J Repa; David W Russell; John M Dietschy; Stephen D Turley
Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid.
Amal Aqul; Dennis K Burns; Sandi Jo Estill; Benny Liu; Bing Liu; Andrew A Pieper; Charina M Ramirez; Joyce J Repa; Stephen D Turley; John M Dietschy
Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment.
Charina M Ramirez; Benny Liu; Amal Aqul; Anna M Taylor; Joyce J Repa; Stephen D Turley; John M Dietschy
Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations.

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All Publications

2012: Ryan D Jones; Joyce J Repa; David W Russell; John M Dietschy; Stephen D Turley
Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid.
American journal of physiology. Gastrointestinal and liver physiology 2012;303(2):G263-74.
2011: Amal Aqul; Dennis K Burns; Sandi Jo Estill; Benny Liu; Bing Liu; Andrew A Pieper; Charina M Ramirez; Joyce J Repa; Stephen D Turley; John M Dietschy
Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(25):9404-13.
2011: Charina M Ramirez; Benny Liu; Amal Aqul; Anna M Taylor; Joyce J Repa; Stephen D Turley; John M Dietschy
Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations.
Journal of lipid research 2011;52(4):688-98.
2010: Stephen D Turley; Mark A Valasek; Joyce J Repa; John M Dietschy
Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(5):G1012-22.
2010: Charina M Ramirez; Benny Liu; Anna M Taylor; Joyce J Repa; Dennis K Burns; Arthur G Weinberg; Stephen D Turley; John M Dietschy
Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life.
Pediatric research 2010;68(4):309-15.
2010: Benny Liu; Charina M Ramirez; Anna M Miller; Joyce J Repa; Stephen D Turley; John M Dietschy
Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid.
Journal of lipid research 2010;51(5):933-44.
2009: Chonglun Xie; Stephen D Turley; John M Dietschy
ABCA1 plays no role in the centripetal movement of cholesterol from peripheral tissues to the liver and intestine in the mouse.
Journal of lipid research 2009;50(7):1316-29.
2009: John M Dietschy
Central nervous system: cholesterol turnover, brain development and neurodegeneration.
Biological chemistry 2009;390(4):287-93.
2009: Benny Liu; Stephen D Turley; Dennis K Burns; Anna M Miller; Joyce J Repa; John M Dietschy
Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2377-82.
2008: Mark A Valasek; Joyce J Repa; Gang Quan; John M Dietschy; Stephen D Turley
Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(4):G813-22.
2008: Hao Li; Stephen D Turley; Benny Liu; Joyce J Repa; John M Dietschy
GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice.
Journal of lipid research 2008;49(8):1816-28.
2008: Benny Liu; Hao Li; Joyce J Repa; Stephen D Turley; John M Dietschy
Genetic variations and treatments that affect the lifespan of the NPC1 mouse.
Journal of lipid research 2008;49(3):663-9.
2007: Joyce J Repa; Hao Li; Tamy C Frank-Cannon; Mark A Valasek; Stephen D Turley; Malú G Tansey; John M Dietschy
Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(52):14470-80.
2007: Benny Liu; Chonglun Xie; James A Richardson; Stephen D Turley; John M Dietschy
Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease.
Journal of lipid research 2007;48(8):1710-23.
2007: Eduardo P Beltroy; Benny Liu; John M Dietschy; Stephen D Turley
Lysosomal unesterified cholesterol content correlates with liver cell death in murine Niemann-Pick type C disease.
Journal of lipid research 2007;48(4):869-81.
2006: Chonglun Xie; James A Richardson; Stephen D Turley; John M Dietschy
Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein.
Journal of lipid research 2006;47(5):953-63.
2005: Eduardo P Beltroy; James A Richardson; Jay D Horton; Stephen D Turley; John M Dietschy
Cholesterol accumulation and liver cell death in mice with Niemann-Pick type C disease.
Hepatology (Baltimore, Md.) 2005;42(4):886-93.
2005: William S Garver; Chonglun Xie; Joyce J Repa; Stephen D Turley; John M Dietschy
Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse.
Journal of lipid research 2005;46(8):1745-54.
2005: Hao Li; Joyce J Repa; Mark A Valasek; Eduardo P Beltroy; Stephen D Turley; Dwight C German; John M Dietschy
Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease.
Journal of neuropathology and experimental neurology 2005;64(4):323-33.
2005: Joyce J Repa; Stephen D Turley; Gang Quan; John M Dietschy
Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption.
Journal of lipid research 2005;46(4):779-89.
2004: Joyce J Repa; Kimberly Buhman; Robert V Farese; John M Dietschy; Stephen D Turley
ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis.
Hepatology (Baltimore, Md.) 2004;40(5):1088-97.
2004: John M Dietschy; Stephen D Turley
Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal.
Journal of lipid research 2004;45(8):1375-97.
2003: Gang Quan; Chonglun Xie; John M Dietschy; Stephen D Turley
Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse.
Brain research. Developmental brain research 2003;146(1-2):87-98.
2003: Chonglun Xie; Erik G Lund; Stephen D Turley; David W Russell; John M Dietschy
Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration.
Journal of lipid research 2003;44(9):1780-9.
2003: Erik G Lund; Chonglun Xie; Tiina Kotti; Stephen D Turley; John M Dietschy; David W Russell
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover.
The Journal of biological chemistry 2003;278(25):22980-8.
2003: Stephen D Turley; John M Dietschy
Sterol absorption by the small intestine.
Current opinion in lipidology 2003;14(3):233-40.
2003: Stephen D Turley; John M Dietschy
The intestinal absorption of biliary and dietary cholesterol as a drug target for lowering the plasma cholesterol level.
Preventive cardiology 2003;6(1):29-33, 64.
2002: Joyce J Repa; John M Dietschy; Stephen D Turley
Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte.
Journal of lipid research 2002;43(11):1864-74.
2002: Chonglun Xie; Laura A Woollett; Stephen D Turley; John M Dietschy
Fatty acids differentially regulate hepatic cholesteryl ester formation and incorporation into lipoproteins in the liver of the mouse.
Journal of lipid research 2002;43(9):1508-19.
2002: John M Dietschy; Stephen D Turley
Control of cholesterol turnover in the mouse.
The Journal of biological chemistry 2002;277(6):3801-4.
2002: Dwight C German; Chang-Lin Liang; T Song; Umar Yazdani; Chonglun Xie; John M Dietschy
Neurodegeneration in the Niemann-Pick C mouse: glial involvement.
Neuroscience 2002;109(3):437-50.
2001: Margrit Schwarz; David W Russell; John M Dietschy; Stephen D Turley
Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding.
Journal of lipid research 2001;42(10):1594-603.
2001: Dwight C German; E M Quintero; Chang-Lin Liang; B Ng; S Punia; Chonglun Xie; John M Dietschy
Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann-Pick C disease.
The Journal of comparative neurology 2001;433(3):415-25.
2001: John M Dietschy; Stephen D Turley
Cholesterol metabolism in the brain.
Current opinion in lipidology 2001;12(2):105-12.
2001: Dwight C German; E M Quintero; C Liang; Chonglun Xie; John M Dietschy
Degeneration of neurons and glia in the Niemann-Pick C mouse is unrelated to the low-density lipoprotein receptor.
Neuroscience 2001;105(4):999-1005.
2000: Joyce J Repa; Erik G Lund; Jay D Horton; eran leitersdorf; David W Russell; John M Dietschy; Stephen D Turley
Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding.
The Journal of biological chemistry 2000;275(50):39685-92.
2000: Chonglun Xie; DK Burns; Stephen D Turley; John M Dietschy
Cholesterol is sequestered in the brains of mice with Niemann-Pick type C disease but turnover is increased.
Journal of neuropathology and experimental neurology 2000;59(12):1106-17.
2000: CD Jolley; John M Dietschy; Stephen D Turley
Induction of bile acid synthesis by cholesterol and cholestyramine feeding is unimpaired in mice deficient in apolipoprotein AI.
Hepatology (Baltimore, Md.) 2000;32(6):1309-16.
2000: Robert W Haley; John M Dietschy
Is there a connection between the concentration of cholesterol circulating in plasma and the rate of neuritic plaque formation in Alzheimer disease?
Archives of neurology 2000;57(10):1410-2.
2000: Joyce J Repa; Stephen D Turley; Jean-Marc Lobaccaro; J Medina; Linheng Li; KD Lustig; Bei Shan; R A Heyman; John M Dietschy; David J Mangelsdorf
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
Science (New York, N.Y.) 2000;289(5484):1524-9.
2000: Chonglun Xie; Stephen D Turley; John M Dietschy
Centripetal cholesterol flow from the extrahepatic organs through the liver is normal in mice with mutated Niemann-Pick type C protein (NPC1).
Journal of lipid research 2000;41(8):1278-89.
1999: Chonglun Xie; Stephen D Turley; John M Dietschy
Cholesterol accumulation in tissues of the Niemann-pick type C mouse is determined by the rate of lipoprotein-cholesterol uptake through the coated-pit pathway in each organ.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11992-7.
1999: CD Jolley; John M Dietschy; Stephen D Turley
Genetic differences in cholesterol absorption in 129/Sv and C57BL/6 mice: effect on cholesterol responsiveness.
The American journal of physiology 1999;276(5 Pt 1):G1117-24.
1999: Chonglun Xie; Stephen D Turley; P G Pentchev; John M Dietschy
Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein.
The American journal of physiology 1999;276(2 Pt 1):E336-44.
1998: CD Jolley; Laura A Woollett; Stephen D Turley; John M Dietschy
Centripetal cholesterol flux to the liver is dictated by events in the peripheral organs and not by the plasma high density lipoprotein or apolipoprotein A-I concentration.
Journal of lipid research 1998;39(11):2143-9.
1998: Stephen D Turley; Margrit Schwarz; david keith spady; John M Dietschy
Gender-related differences in bile acid and sterol metabolism in outbred CD-1 mice fed low- and high-cholesterol diets.
Hepatology (Baltimore, Md.) 1998;28(4):1088-94.
1998: Margrit Schwarz; David W Russell; John M Dietschy; Stephen D Turley
Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.
Journal of lipid research 1998;39(9):1833-43.
1998: Stephen D Turley; DK Burns; John M Dietschy
Preferential utilization of newly synthesized cholesterol for brain growth in neonatal lambs.
The American journal of physiology 1998;274(6 Pt 1):E1099-105.
1998: John M Dietschy
Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations.
The Journal of nutrition 1998;128(2 Suppl):444S-448S.
1997: Stephen D Turley; david keith spady; John M Dietschy
Identification of a metabolic difference accounting for the hyper- and hyporesponder phenotypes of cynomolgus monkey.
Journal of lipid research 1997;38(8):1598-611.
1997: John M Dietschy
Theoretical considerations of what regulates low-density-lipoprotein and high-density-lipoprotein cholesterol.
The American journal of clinical nutrition 1997;65(5 Suppl):1581S-1589S.
1997: Stephen D Turley; david keith spady; John M Dietschy
Regulation of fecal bile acid excretion in male golden Syrian hamsters fed a cereal-based diet with and without added cholesterol.
Hepatology (Baltimore, Md.) 1997;25(4):797-803.
1996: Stephen D Turley; DK Burns; C R Rosenfeld; John M Dietschy
Brain does not utilize low density lipoprotein-cholesterol during fetal and neonatal development in the sheep.
Journal of lipid research 1996;37(9):1953-61.
1996: Y Osono; Laura A Woollett; Keith Marotti; G W Melchior; John M Dietschy
Centripetal cholesterol flux from extrahepatic organs to the liver is independent of the concentration of high density lipoprotein-cholesterol in plasma.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4114-9.
1996: Stephen D Turley; B P Daggy; John M Dietschy
Effect of feeding psyllium and cholestyramine in combination on low density lipoprotein metabolism and fecal bile acid excretion in hamsters with dietary-induced hypercholesterolemia.
Journal of cardiovascular pharmacology 1996;27(1):71-9.
1995: Laura A Woollett; Y Osono; Joachim Herz; John M Dietschy
Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12500-4.
1995: C P Cavender; Stephen D Turley; John M Dietschy
Sterol metabolism in fetal, newborn, and suckled lambs and their response to cholesterol after weaning.
The American journal of physiology 1995;269(2 Pt 1):E331-40.
1995: Marco Bertolotti; david keith spady; John M Dietschy
Regulation of hepatic cholesterol metabolism in the rat in vivo: effect of a synthetic fat-free diet on sterol synthesis and low-density lipoprotein transport.
Biochimica et biophysica acta 1995;1255(3):293-300.
1995: Stephen D Turley; John M Dietschy
Mechanisms of LDL-cholesterol lowering action of psyllium hydrophillic mucilloid in the hamster.
Biochimica et biophysica acta 1995;1255(2):177-84.
1995: Y Osono; Laura A Woollett; Joachim Herz; John M Dietschy
Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse.
The Journal of clinical investigation 1995;95(3):1124-32.
1995: Stephen D Turley; david keith spady; John M Dietschy
Role of liver in the synthesis of cholesterol and the clearance of low density lipoproteins in the cynomolgus monkey.
Journal of lipid research 1995;36(1):67-79.
1994: Laura A Woollett; John M Dietschy
Effect of long-chain fatty acids on low-density-lipoprotein-cholesterol metabolism.
The American journal of clinical nutrition 1994;60(6 Suppl):991S-996S.
1994: Laura A Woollett; C M Daumerie; John M Dietschy
Trans-9-octadecenoic acid is biologically neutral and does not regulate the low density lipoprotein receptor as the cis isomer does in the hamster.
Journal of lipid research 1994;35(9):1661-73.
1994: Stephen D Turley; B P Daggy; John M Dietschy
Psyllium augments the cholesterol-lowering action of cholestyramine in hamsters by enhancing sterol loss from the liver.
Gastroenterology 1994;107(2):444-52.
1994: Stephen D Turley; M W Herndon; John M Dietschy
Reevaluation and application of the dual-isotope plasma ratio method for the measurement of intestinal cholesterol absorption in the hamster.
Journal of lipid research 1994;35(2):328-39.
1993: John M Dietschy; Stephen D Turley; david keith spady
Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans.
Journal of lipid research 1993;34(10):1637-59.
1993: John M Dietschy; Laura A Woollett; david keith spady
The interaction of dietary cholesterol and specific fatty acids in the regulation of LDL receptor activity and plasma LDL-cholesterol concentrations.
Annals of the New York Academy of Sciences 1993;676():11-26.
1993: david keith spady; Laura A Woollett; John M Dietschy
Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids.
Annual review of nutrition 1993;13():355-81.
1992: C M Daumerie; Laura A Woollett; John M Dietschy
Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10797-801.
1992: Laura A Woollett; david keith spady; John M Dietschy
Regulatory effects of the saturated fatty acids 6:0 through 18:0 on hepatic low density lipoprotein receptor activity in the hamster.
The Journal of clinical investigation 1992;89(4):1133-41.
1992: Laura A Woollett; david keith spady; John M Dietschy
Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.
Journal of lipid research 1992;33(1):77-88.
1991: Stephen D Turley; B P Daggy; John M Dietschy
Cholesterol-lowering action of psyllium mucilloid in the hamster: sites and possible mechanisms of action.
Metabolism: clinical and experimental 1991;40(10):1063-73.
1990: John M Dietschy
LDL cholesterol: its regulation and manipulation.
Hospital practice (Office ed.) 1990;25(6):67-78.
1989: L E Bilhartz; david keith spady; John M Dietschy
Inappropriate hepatic cholesterol synthesis expands the cellular pool of sterol available for recruitment by bile acids in the rat.
The Journal of clinical investigation 1989;84(4):1181-7.
1989: Jonathan B Meddings; John M Dietschy
A rapid method to assess the hydrophobicity of the intestinal microvillus membrane in vivo.
Journal of lipid research 1989;30(8):1289-96.
1989: Laura A Woollett; david keith spady; John M Dietschy
Mechanisms by which saturated triacylglycerols elevate the plasma low density lipoprotein-cholesterol concentration in hamsters. Differential effects of fatty acid chain length.
The Journal of clinical investigation 1989;84(1):119-28.
1989: david keith spady; John M Dietschy
Interaction of aging and dietary fat in the regulation of low density lipoprotein transport in the hamster.
Journal of lipid research 1989;30(4):559-69.
1988: W M Belknap; John M Dietschy
Sterol synthesis and low density lipoprotein clearance in vivo in the pregnant rat, placenta, and fetus. Sources for tissue cholesterol during fetal development.
The Journal of clinical investigation 1988;82(6):2077-85.
1988: John M Dietschy
A time for change.
Gastroenterology 1988;95(6):1441-6.
1988: L E Bilhartz; John M Dietschy
Bile salt hydrophobicity influences cholesterol recruitment from rat liver in vivo when cholesterol synthesis and lipoprotein uptake are constant.
Gastroenterology 1988;95(3):771-9.
1988: david keith spady; John M Dietschy
Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster.
The Journal of clinical investigation 1988;81(2):300-9.
1986: R V Clayman; L E Bilhartz; L Maximilian Buja; david keith spady; John M Dietschy
Renal cell carcinoma in the Wistar-Lewis rat: a model for studying the mechanisms of cholesterol acquisition by a tumor in vivo.
Cancer research 1986;46(6):2958-63.
1986: david keith spady; E F Stange; L E Bilhartz; John M Dietschy
Bile acids regulate hepatic low density lipoprotein receptor activity in the hamster by altering cholesterol flux across the liver.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1916-20.
1986: R V Clayman; L E Bilhartz; david keith spady; L Maximilian Buja; John M Dietschy
Low density lipoprotein-receptor activity is lost in vivo in malignantly transformed renal tissue.
FEBS letters 1986;196(1):87-90.
1968: John M Dietschy; Jean D Wilson
Cholesterol synthesis in the squirrel monkey: relative rates of synthesis in various tissues and mechanisms of control.
The Journal of clinical investigation 1968;47(1):166-74.