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John Diffley

Research Profile

Physiology

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Saccharomyces cerevisiae

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Publications

TOP 3
Jordi Frigola; Amina Mehanna; Dirk Remus; John F X Diffley
ATPase-dependent quality control of DNA replication origin licensing.
Mona Yekezare; Belén Gómez-González; John F X Diffley
Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally.
Amina Mehanna; John F X Diffley
Pre-replicative complex assembly with purified proteins.

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All Publications

2013: Jordi Frigola; Amina Mehanna; Dirk Remus; John F X Diffley
ATPase-dependent quality control of DNA replication origin licensing.
Nature 2013;495(7441):339-43.
2013: Mona Yekezare; Belén Gómez-González; John F X Diffley
Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally.
Journal of cell science 2013;126(Pt 6):1297-306.
2012: Amina Mehanna; John F X Diffley
Pre-replicative complex assembly with purified proteins.
Methods (San Diego, Calif.) 2012;57(2):222-6.
2012: Dominik Boos; Jordi Frigola; John F X Diffley
Activation of the replicative DNA helicase: breaking up is hard to do.
Current opinion in cell biology 2012;24(3):423-30.
2012: Max E Douglas; John F X Diffley
Replication timing: the early bird catches the worm.
Current biology : CB 2012;22(3):R81-2.
2011: John F X Diffley
Quality control in the initiation of eukaryotic DNA replication.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1584):3545-53.
2011: Dominik Boos; Antony Oliver; Laurence H Pearl; Chris P Ponting; Mathieu Rappas; Luis Sanchez-Pulido; John F X Diffley
Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.
Current biology : CB 2011;21(13):1152-7.
2010: Philip Zegerman; John F X Diffley
Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation.
Nature 2010;467(7314):474-8.
2010: Luis Sanchez-Pulido; John F X Diffley; Chris P Ponting
Homology explains the functional similarities of Treslin/Ticrr and Sld3.
Current biology : CB 2010;20(12):R509-10.
2010: John F X Diffley
The many faces of redundancy in DNA replication control.
Cold Spring Harbor symposia on quantitative biology 2010;75():135-42.
2009: Dirk Remus; John F X Diffley
Eukaryotic DNA replication control: lock and load, then fire.
Current opinion in cell biology 2009;21(6):771-7.
2009: Dirk Remus; Fabienne Beuron; Gökhan Tolun; Jack D Griffith; Edward P Morris; John F X Diffley
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.
Cell 2009;139(4):719-30.
2009: Philip Zegerman; John F X Diffley
DNA replication as a target of the DNA damage checkpoint.
DNA repair 2009;8(9):1077-88.
2009: Lucy S Drury; John F X Diffley
Factors affecting the diversity of DNA replication licensing control in eukaryotes.
Current biology : CB 2009;19(6):530-5.
2009: Larsson Omberg; Joel R Meyerson; Kayta Kobayashi; Lucy S Drury; John F X Diffley; Orly Alter
Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression.
Molecular systems biology 2009;5():312.
2008: Christian Zierhut; John F X Diffley
Break dosage, cell cycle stage and DNA replication influence DNA double strand break response.
The EMBO journal 2008;27(13):1875-85.
2008: Monica Segurado; John F X Diffley
Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.
Genes & development 2008;22(13):1816-27.
2008: Jonathan Baxter; John F X Diffley
Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast.
Molecular cell 2008;30(6):790-802.
2007: Philip Zegerman; John F X Diffley
Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.
Nature 2007;445(7125):281-5.
2005: Niels Mailand; John F X Diffley
CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis.
Cell 2005;122(6):915-26.
2004: Satoru Mimura; Takashi Seki; Seiji Tanaka; John F X Diffley
Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control.
Nature 2004;431(7012):1118-23.
2004: John F X Diffley
Regulation of early events in chromosome replication.
Current biology : CB 2004;14(18):R778-86.
2004: Xuan Wang; Grzegorz Ira; José Antonio Tercero; Allyson M Holmes; John F X Diffley; James E Haber
Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae.
Molecular and cellular biology 2004;24(16):6891-9.
2004: Catherine J Merrick; Dean Jackson; John F X Diffley
Visualization of altered replication dynamics after DNA damage in human cells.
The Journal of biological chemistry 2004;279(19):20067-75.
2004: Anne Early; Lucy S Drury; John F X Diffley
Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2004;359(1441):31-8.
2003: Philip Zegerman; John F X Diffley
Lessons in how to hold a fork.
Nature structural biology 2003;10(10):778-9.
2003: Laurence Vernis; Jure Piskur; John F X Diffley
Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae.
Nucleic acids research 2003;31(19):e120.
2003: José Antonio Tercero; Maria Pia Longhese; John F X Diffley
A central role for DNA replication forks in checkpoint activation and response.
Molecular cell 2003;11(5):1323-36.
2002: Seiji Tanaka; John F X Diffley
Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation.
Genes & development 2002;16(20):2639-49.
2002: John F X Diffley; Karim Labib
The chromosome replication cycle.
Journal of cell science 2002;115(Pt 5):869-72.
2002: Seiji Tanaka; John F X Diffley
Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase.
Nature cell biology 2002;4(3):198-207.
2001: Annette A Alcasabas; A J Osborn; Jeff Bachant; Fenghua Hu; Petra J H Werler; Kristine Bousset; K Furuya; John F X Diffley; Antony M Carr; Stephen J Elledge
Mrc1 transduces signals of DNA replication stress to activate Rad53.
Nature cell biology 2001;3(11):958-65.
2001: Karim Labib; Stephen E Kearsey; John F X Diffley
MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint.
Molecular biology of the cell 2001;12(11):3658-67.
2001: G Perkins; Lucy S Drury; John F X Diffley
Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.
The EMBO journal 2001;20(17):4836-45.
2001: Aloys Schepers; Marion Ritzi; Kristine Bousset; Elisabeth Kremmer; J L Yates; J Harwood; John F X Diffley; Wolfgang Hammerschmidt
Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus.
The EMBO journal 2001;20(16):4588-602.
2001: José Antonio Tercero; John F X Diffley
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint.
Nature 2001;412(6846):553-7.
2001: Aloys Schepers; John F X Diffley
Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein.
Journal of molecular biology 2001;308(4):597-608.
2001: John F X Diffley
DNA replication: building the perfect switch.
Current biology : CB 2001;11(9):R367-70.
2001: Karim Labib; John F X Diffley
Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?
Current opinion in genetics & development 2001;11(1):64-70.
2000: T Seki; John F X Diffley
Stepwise assembly of initiation proteins at budding yeast replication origins in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14115-20.
2000: Karim Labib; José Antonio Tercero; John F X Diffley
Uninterrupted MCM2-7 function required for DNA replication fork progression.
Science (New York, N.Y.) 2000;288(5471):1643-7.
2000: José Antonio Tercero; Karim Labib; John F X Diffley
DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p.
The EMBO journal 2000;19(9):2082-93.
2000: Lucy S Drury; G Perkins; John F X Diffley
The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle.
Current biology : CB 2000;10(5):231-40.
2000: John F X Diffley; Kristine Bousset; Karim Labib; E A Noton; C Santocanale; José Antonio Tercero
Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast.
Cold Spring Harbor symposia on quantitative biology 2000;65():333-42.
2000: E Noton; John F X Diffley
CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis.
Molecular cell 2000;5(1):85-95.
2000: Miguel Godinho Ferreira; C Santocanale; Lucy S Drury; John F X Diffley
Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex.
Molecular and cellular biology 2000;20(1):242-8.
1999: Karim Labib; John F X Diffley; Stephen E Kearsey
G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus.
Nature cell biology 1999;1(7):415-22.
1999: C Santocanale; K Sharma; John F X Diffley
Activation of dormant origins of DNA replication in budding yeast.
Genes & development 1999;13(18):2360-4.
1998: C Santocanale; John F X Diffley
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication.
Nature 1998;395(6702):615-8.
1998: C Desdouets; C Santocanale; Lucy S Drury; G Perkins; Marco Foiani; Paolo Plevani; John F X Diffley
Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha.
The EMBO journal 1998;17(14):4139-46.
1998: G Perkins; John F X Diffley
Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders.
Molecular cell 1998;2(1):23-32.
1998: Kristine Bousset; John F X Diffley
The Cdc7 protein kinase is required for origin firing during S phase.
Genes & development 1998;12(4):480-90.
1997: Lucy S Drury; G Perkins; John F X Diffley
The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast.
The EMBO journal 1997;16(19):5966-76.
1997: S Donovan; J Harwood; Lucy S Drury; John F X Diffley
Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5611-6.
1997: C Santocanale; John F X Diffley
Genomic footprinting of budding yeast replication origins during the cell cycle.
Methods in enzymology 1997;283():377-90.
1996: C Santocanale; John F X Diffley
ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae.
The EMBO journal 1996;15(23):6671-9.
1996: Simonetta Piatti; T Böhm; J H Cocker; John F X Diffley; Kim Nasmyth
Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast.
Genes & development 1996;10(12):1516-31.
1996: S Donovan; John F X Diffley
Replication origins in eukaroytes.
Current opinion in genetics & development 1996;6(2):203-7.
1996: J H Cocker; Simonetta Piatti; C Santocanale; Kim Nasmyth; John F X Diffley
An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast.
Nature 1996;379(6561):180-2.
1995: A Rowley; J H Cocker; J Harwood; John F X Diffley
Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.
The EMBO journal 1995;14(11):2631-41.
1995: John F X Diffley; J H Cocker; S J Dowell; J Harwood; A Rowley
Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle.
Journal of cell science. Supplement 1995;19():67-72.
1994: S J Dowell; P Romanowski; John F X Diffley
Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo.
Science (New York, N.Y.) 1994;265(5176):1243-6.
1994: John F X Diffley; J H Cocker; S J Dowell; A Rowley
Two steps in the assembly of complexes at yeast replication origins in vivo.
Cell 1994;78(2):303-16.
1994: A Rowley; S J Dowell; John F X Diffley
Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges.
Biochimica et biophysica acta 1994;1217(3):239-56.
1993: G Micklem; A Rowley; J Harwood; Kim Nasmyth; John F X Diffley
Yeast origin recognition complex is involved in DNA replication and transcriptional silencing.
Nature 1993;366(6450):87-9.
1992: John F X Diffley
Early events in eukaryotic DNA replication.
Trends in cell biology 1992;2(10):298-303.
1992: John F X Diffley
Global regulators of chromosome function in yeast.
Antonie van Leeuwenhoek 1992;62(1-2):25-33.
1992: John F X Diffley; J H Cocker
Protein-DNA interactions at a yeast replication origin.
Nature 1992;357(6374):169-72.
1992: John F X Diffley; B Stillman
DNA binding properties of an HMG1-related protein from yeast mitochondria.
The Journal of biological chemistry 1992;267(5):3368-74.