John DiGiovanni

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Kim Dae Joon; Kataoka Ken; Rao Dharanija; Kiguchi Kaoru; Cotsarelis George; Digiovanni John
Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation.
Kim Dae Joon; Kataoka Ken; Sano Shigetoshi; Connolly Kevin; Kiguchi Kaoru; DiGiovanni John
Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis.
Moral Marta; Segrelles Carmen; Martínez-Cruz Ana Belén; Lorz Corina; Santos Mirentxu; García-Escudero Ramón; Lu Jerry; Buitrago Agueda; Costa Clotilde; Saiz Cristina; Ariza José M; Dueñas Marta; Rodriguez-Peralto Jose L; Martinez-Tello Francisco J; Rodriguez-Pinilla Maria; Sanchez-Cespedes Montserrat; Digiovanni John; Paramio Jesús M
Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma.

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All Publications

2009: Kim Dae Joon; Kataoka Ken; Rao Dharanija; Kiguchi Kaoru; Cotsarelis George; Digiovanni John
Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation.
Cancer research 2009;69(19):7587-94.
2009: Kim Dae Joon; Kataoka Ken; Sano Shigetoshi; Connolly Kevin; Kiguchi Kaoru; DiGiovanni John
Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis.
Molecular carcinogenesis 2009;48(10):873-85.
2009: Moral Marta; Segrelles Carmen; Martínez-Cruz Ana Belén; Lorz Corina; Santos Mirentxu; García-Escudero Ramón; Lu Jerry; Buitrago Agueda; Costa Clotilde; Saiz Cristina; Ariza José M; Dueñas Marta; Rodriguez-Peralto Jose L; Martinez-Tello Francisco J; Rodriguez-Pinilla Maria; Sanchez-Cespedes Montserrat; Digiovanni John; Paramio Jesús M
Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma.
In vivo (Athens, Greece) 2009;23(5):653-60.
2009: Chen Xin; Schneider-Broussard Robin; Hollowell Debra; McArthur Mark; Jeter Collene R; Benavides Fernando; DiGiovanni John; Tang Dean G
Abnormal differentiation, hyperplasia and embryonic/perinatal lethality in BK5-T/t transgenic mice.
Differentiation; research in biological diversity 2009;77(3):324-34.
2009: Kim D J; Angel J M; Sano S; DiGiovanni J
Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis.
Oncogene 2009;28(7):950-60.
2009: Abel Erika L; Angel Joe M; Kiguchi Kaoru; DiGiovanni John
Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications.
Nature protocols 2009;4(9):1350-62.
2009: Brandon Jimi Lynn; Conti Claudio J; Goldstein Lawrence S; DiGiovanni John; Gimenez-Conti Irma B
Carcinogenic effects of MGP-7 and B[a]P on the hamster cheek pouch.
Toxicologic pathology 2009;37(6):733-40.
2008: Kleiner Heather E; Xia Xiaojun; Sonoda Junichiro; Zhang Jun; Pontius Elizabeth; Abey Jane; Evans Ronald M; Moore David D; DiGiovanni John
Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice.
Toxicology and applied pharmacology 2008;232(2):337-50.
2008: Liu Bigang; Xia Xiaojun; Zhu Feng; Park Eunmi; Carbajal Steve; Kiguchi Kaoru; DiGiovanni John; Fischer Susan M; Hu Yinling
IKKalpha is required to maintain skin homeostasis and prevent skin cancer.
Cancer cell 2008;14(3):212-25.
2008: de Ostrovich Krisztina Kovács; Lambertz Isabel; Colby Jennifer K L; Tian Jie; Rundhaug Joyce E; Johnston Dennis; Conti Claudio J; DiGiovanni John; Fuchs-Young Robin
Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo.
The American journal of pathology 2008;173(3):824-34.
2008: Kataoka Ken; Kim Dae Joon; Carbajal Steve; Clifford John L; DiGiovanni John
Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis.
Carcinogenesis 2008;29(6):1108-14.
2008: Strom Sara S; Yamamura Yuko; Forman Michele R; Pettaway Curtis A; Barrera Stephanie L; DiGiovanni John
Saturated fat intake predicts biochemical failure after prostatectomy.
International journal of cancer. Journal international du cancer 2008;122(11):2581-5.
2008: Moore Tricia; Carbajal Steve; Beltran Linda; Perkins Susan N; Yakar Shoshana; Leroith Derek; Hursting Stephen D; Digiovanni John
Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels.
Cancer research 2008;68(10):3680-8.
2008: Chan K S; Sano S; Kataoka K; Abel E; Carbajal S; Beltran L; Clifford J; Peavey M; Shen J; Digiovanni J
Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis.
Oncogene 2008;27(8):1087-94.
2008: Segrelles Carmen; Moral Marta; Lorz Corina; Santos Mirentxu; Lu Jerry; Cascallana José Luis; Lara M Fernanda; Carbajal Steve; Martínez-Cruz Ana Belén; García-Escudero Ramón; Beltran Linda; Segovia José C; Bravo Ana; DiGiovanni John; Paramio Jesús M
Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling.
Molecular biology of the cell 2008;19(1):137-49.
2007: Lu Jerry; Rho Okkyung; Wilker Erik; Beltran Linda; Digiovanni John
Activation of epidermal akt by diverse mouse skin tumor promoters.
Molecular cancer research : MCR 2007;5(12):1342-52.
2007: Lee Sangjun; Chari Nikhil S; Kim Hyung Woo; Wang Xuemei; Roop Dennis R; Cho Song H; DiGiovanni John; McDonnell Timothy J
Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis.
Molecular carcinogenesis 2007;46(12):949-57.
2007: Segrelles Carmen; Lu Jerry; Hammann Brian; Santos Mirentxu; Moral Marta; Cascallana José Luis; Lara M Fernanda; Rho Okkyung; Carbajal Steve; Traag Jeanine; Beltrán Linda; Martínez-Cruz Ana Belén; García-Escudero Ramón; Lorz Corina; Ruiz Sergio; Bravo Ana; Paramio Jesús M; DiGiovanni John
Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis.
Cancer research 2007;67(22):10879-88.
2007: Kim Dae Joon; Chan Keith S; Sano Shigetoshi; Digiovanni John
Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis.
Molecular carcinogenesis 2007;46(8):725-31.
2007: Kiguchi Kaoru; Ruffino Lynnsie; Kawamoto Toru; Franco Eugenia; Kurakata Shin-ichi; Fujiwara Kosaku; Hanai Masaharu; Rumi Mohammad; DiGiovanni John
Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice.
Molecular cancer therapeutics 2007;6(6):1709-17.
2007: Shen Jianjun; Riggs Penny K; Hensley Sean C; Schroeder Lisa J; Traner Angelina R; Kochan Kelli J; Person Maria D; DiGiovanni John
Differential expression of multiple anti-apoptotic proteins in epidermis of IGF-1 transgenic mice as revealed by 2-dimensional gel electrophoresis/mass spectrometry analysis.
Molecular carcinogenesis 2007;46(5):331-40.
2007: Wu Qi; Kiguchi Kaoru; Kawamoto Toru; Ajiki Tetsuo; Traag Jeanine; Carbajal Steve; Ruffino Lynnsie; Thames Howard; Wistuba Ignacio; Thomas Melanie; Vasquez Karen M; DiGiovanni John
Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model.
Cancer research 2007;67(8):3794-800.
2007: Wu Qi; Gaddis Sara S; MacLeod Michael C; Walborg Earl F; Thames Howard D; DiGiovanni John; Vasquez Karen M
High-affinity triplex-forming oligonucleotide target sequences in mammalian genomes.
Molecular carcinogenesis 2007;46(1):15-23.
2006: He Guobin; Sung You Me; Digiovanni John; Fischer Susan M
Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity.
Cancer research 2006;66(3):1873-8.
2006: Gaddis Sara S; Wu Qi; Thames Howard D; DiGiovanni John; Walborg Earl F; MacLeod Michael C; Vasquez Karen M
A web-based search engine for triplex-forming oligonucleotide target sequences.
Oligonucleotides 2006;16(2):196-201.
2005: Wilker Erik; Lu Jerry; Rho Okkyung; Carbajal Steve; Beltrán Linda; DiGiovanni John
Role of PI3K/Akt signaling in insulin-like growth factor-1 (IGF-1) skin tumor promotion.
Molecular carcinogenesis 2005;44(2):137-45.
2005: Riggs Penny K; Angel Joe M; Abel Erika L; DiGiovanni John
Differential gene expression in epidermis of mice sensitive and resistant to phorbol ester skin tumor promotion.
Molecular carcinogenesis 2005;44(2):122-36.
2005: Kiguchi Kaoru; Ruffino Lynnsie; Kawamoto Toru; Ajiki Tetsuo; Digiovanni John
Chemopreventive and therapeutic efficacy of orally active tyrosine kinase inhibitors in a transgenic mouse model of gallbladder carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5572-80.
2005: Mammen Jennifer S; Kleiner Heather E; DiGiovanni John; Sutter Thomas R; Strickland Paul T
Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants.
Pharmacogenetics and genomics 2005;15(3):183-8.
2005: Sano Shigetoshi; Chan Keith Syson; Carbajal Steve; Clifford John; Peavey Mary; Kiguchi Kaoru; Itami Satoshi; Nickoloff Brian J; DiGiovanni John
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model.
Nature medicine 2005;11(1):43-9.
2004: Kleiner Heather E; Vulimiri Suryanarayana V; Hatten William B; Reed Melissa J; Nebert Daniel W; Jefcoate Colin R; DiGiovanni John
Role of cytochrome p4501 family members in the metabolic activation of polycyclic aromatic hydrocarbons in mouse epidermis.
Chemical research in toxicology 2004;17(12):1667-74.
2004: Chan Keith Syson; Sano Shigetoshi; Kiguchi Kaoru; Anders Joanne; Komazawa Nobuyasu; Takeda Junji; DiGiovanni John
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.
The Journal of clinical investigation 2004;114(5):720-8.
2004: Matsumoto Takashi; Kiguchi Kaoru; Jiang Jianghong; Carbajal Steve; Ruffino Lynnsie; Beltrán Linda; Wang Xiao-Jing; Roop Dennis R; DiGiovanni John
Development of transgenic mice that inducibly express an active form of c-Src in the epidermis.
Molecular carcinogenesis 2004;40(4):189-200.
2004: Soliman Amr S; Vulimiri Suryanarayana V; Kleiner Heather E; Shen Jianjun; Eissa Saad; Morad Magda; Taha Hala; Lukmanji Farzana; Li Donghui; Johnston Dennis A; Lo Herng-Hsang; Lau Serrine; Digiovanni John; Bondy Melissa L
High levels of oxidative DNA damage in lymphocyte DNA of premenopausal breast cancer patients from Egypt.
International journal of environmental health research 2004;14(2):121-34.
2004: Chan Keith Syson; Carbajal Steve; Kiguchi Kaoru; Clifford John; Sano Shigetoshi; DiGiovanni John
Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis.
Cancer research 2004;64(7):2382-9.
2004: Salas Thomas R; Kim Jeri; Vakar-Lopez Funda; Sabichi Anita L; Troncoso Patricia; Jenster Guido; Kikuchi Akira; Chen Shao-Yong; Shemshedini Lirim; Suraokar Milind; Logothetis Christopher J; DiGiovanni John; Lippman Scott M; Menter David G
Glycogen synthase kinase-3 beta is involved in the phosphorylation and suppression of androgen receptor activity.
The Journal of biological chemistry 2004;279(18):19191-200.
2003: Matsumoto Takashi; Jiang Jianghong; Kiguchi Kaoru; Ruffino Lynnsie; Carbajal Steve; Beltrán Linda; Bol David K; Rosenberg Michael P; DiGiovanni John
Targeted expression of c-Src in epidermal basal cells leads to enhanced skin tumor promotion, malignant progression, and metastasis.
Cancer research 2003;63(16):4819-28.
2003: Soliman Amr S; Wang Xuemei; DiGiovanni John; Eissa Saad; Morad Magda; Vulimiri Sury; Mahgoub Khaled G; Johnston Dennis A; Do Kim-Anh; Seifeldin Ibrahim A; Boffetta Paolo; Bondy Melissa L
Serum organochlorine levels and history of lactation in Egypt.
Environmental research 2003;92(2):110-7.
2003: Angel Joe M; Caballero Manuel; DiGiovanni John
Identification of novel genetic loci contributing to 12-O-tetradecanoylphorbol-13-acetate skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice.
Cancer research 2003;63(11):2747-51.
2003: Kleiner Heather E; Reed Melissa J; DiGiovanni John
Naturally occurring coumarins inhibit human cytochromes P450 and block benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene DNA adduct formation in MCF-7 cells.
Chemical research in toxicology 2003;16(3):415-22.
2003: Liu Zhensheng; Wang Li-E; Strom Sara S; Spitz Margaret R; Babaian Richard J; DiGiovanni John; Wei Qingyi
Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis.
Molecular carcinogenesis 2003;36(3):123-9.
2002: Kleiner Heather E; Vulimiri Suryanarayana V; Starost Matthew F; Reed Melissa J; DiGiovanni John
Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Carcinogenesis 2002;23(10):1667-75.
2002: Matsumoto Takashi; Jiang Jianghong; Kiguchi Kaoru; Carbajal Steve; Rho Okkyung; Gimenez-Conti Irma; Beltrán Linda; DiGiovanni John
Overexpression of a constitutively active form of c-src in skin epidermis increases sensitivity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Molecular carcinogenesis 2002;33(3):146-55.
2002: Kleiner Heather E; Vulimiri Suryanarayana V; Reed Melissa J; Uberecken Ann; DiGiovanni John
Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation.
Chemical research in toxicology 2002;15(2):226-35.
2002: Li Donghui; Firozi Pervez F; Zhang Weiqing; Shen Jianjun; DiGiovanni John; Lau Serrine; Evans Douglas; Friess Helmut; Hassan Manal; Abbruzzese James L
DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer.
Mutation research 2002;513(1-2):37-48.
2002: Li Donghui; Wang Mianying; Firozi Pervez Firoz; Chang Ping; Zhang Weiqing; Baer-Dubowska Wanda; Moorthy Bhagavatula; Vulimiri Suryanarayana V; Goth-Goldstein Regine; Weyand Eric H; DiGiovanni John
Characterization of a major aromatic DNA adduct detected in human breast tissues.
Environmental and molecular mutagenesis 2002;39(2-3):193-200.
2001: Angel J M; Caballero M; DiGiovanni J
Confirmation of the mapping of a 12-O-tetradecanoylphorbol-13-acetate promotion susceptibility locus, Psl1, to distal mouse chromosome 9.
Molecular carcinogenesis 2001;32(4):169-75.
2001: Kiguchi K; Carbajal S; Chan K; Beltrán L; Ruffino L; Shen J; Matsumoto T; Yoshimi N; DiGiovanni J
Constitutive expression of ErbB-2 in gallbladder epithelium results in development of adenocarcinoma.
Cancer research 2001;61(19):6971-6.
2001: Li D; Zhang W; Zhu J; Chang P; Sahin A; Singletary E; Bondy M; Hazra T; Mitra S; Lau S S; Shen J; DiGiovanni J
Oxidative DNA damage and 8-hydroxy-2-deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancer.
Molecular carcinogenesis 2001;31(4):214-23.
2001: Kleiner H E; Vulimiri S V; Miller L; Johnson W H; Whitman C P; DiGiovanni J
Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice.
Carcinogenesis 2001;22(1):73-82.
2000: Tang M S; Vulimiri S V; Viaje A; Chen J X; Bilolikar D S; Morris R J; Harvey R G; Slaga T J; DiGiovanni J
Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.
Cancer research 2000;60(20):5688-95.
2000: Kiguchi K; Bol D; Carbajal S; Beltrán L; Moats S; Chan K; Jorcano J; DiGiovanni J
Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development.
Oncogene 2000;19(37):4243-54.
2000: Benavides F; Stern M C; Glasscock E; DiGiovanni J; Coghlan L G; Conti C J
Microsatellite DNA variants between the inbred SENCAR mouse strains.
Molecular carcinogenesis 2000;28(4):191-5.
2000: Coghlan L G; Gimenez-Conti I; Kleiner H E; Fischer S M; Rundhaug J E; Conti C J; Slaga T J; DiGiovanni J
Development and initial characterization of several new inbred strains of SENCAR mice for studies of multistage skin carcinogenesis.
Carcinogenesis 2000;21(4):641-6.
2000: Riggs P K; Rho O; DiGiovanni J
Alteration of Egr-1 mRNA during multistage carcinogenesis in mouse skin.
Molecular carcinogenesis 2000;27(4):247-51.
2000: DiGiovanni J; Bol D K; Wilker E; Beltrán L; Carbajal S; Moats S; Ramirez A; Jorcano J; Kiguchi K
Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion.
Cancer research 2000;60(6):1561-70.
2000: DiGiovanni J; Kiguchi K; Frijhoff A; Wilker E; Bol D K; Beltrán L; Moats S; Ramirez A; Jorcano J; Conti C
Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3455-60.
2000: Angel J M; Popova N; Lanko N; Turusov V S; DiGiovanni J
A locus that influences susceptibility to 1, 2-dimethylhydrazine-induced colon tumors maps to the distal end of mouse chromosome 3.
Molecular carcinogenesis 2000;27(1):47-54.
2000: Vulimiri S V; Wu X; Baer-Dubowska W; de Andrade M; Detry M; Spitz M R; DiGiovanni J
Analysis of aromatic DNA adducts and 7,8-dihydro-8-oxo- 2'-deoxyguanosine in lymphocyte DNA from a case-control study of lung cancer involving minority populations.
Molecular carcinogenesis 2000;27(1):34-46.
1999: Wilker E; Bol D; Kiguchi K; Rupp T; Beltrán L; DiGiovanni J
Enhancement of susceptibility to diverse skin tumor promoters by activation of the insulin-like growth factor-1 receptor in the epidermis of transgenic mice.
Molecular carcinogenesis 1999;25(2):122-31.
1999: DiGiovanni J; Johnston D A; Rupp T; Sasser L B; Anderson L E; Morris J E; Miller D L; Kavet R; Walborg E F
Lack of effect of a 60 Hz magnetic field on biomarkers of tumor promotion in the skin of SENCAR mice.
Carcinogenesis 1999;20(4):685-9.
1999: Vulimiri S V; Baer-Dubowska W; Harvey R G; Zhang J T; DiGiovanni J
Analysis of highly polar DNA adducts formed in SENCAR mouse epidermis following topical application of dibenz[a,j]anthracene.
Chemical research in toxicology 1999;12(1):60-7.
1999: Angel J M; DiGiovanni J
Genetics of skin tumor promotion.
Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progrès de la recherche expérimentale des tumeurs 1999;35():143-57.
1998: Kiguchi K; Kagehara M; Higo R; Iwamori M; DiGiovanni J
Alterations in cholesterol sulfate and its biosynthetic enzyme during multistage carcinogenesis in mouse skin.
The Journal of investigative dermatology 1998;111(6):973-81.
1998: Walborg E F; DiGiovanni J; Conti C J; Slaga T J; Freeman J J; Steup D R; Skisak C M
Short-term biomarkers of tumor promotion in mouse skin treated with petroleum middle distillates.
Toxicological sciences : an official journal of the Society of Toxicology 1998;45(2):137-45.
1998: Sasser L B; Anderson L E; Morris J E; Miller D L; Walborg E F; Kavet R; Johnston D A; DiGiovanni J
Lack of a co-promoting effect of a 60 Hz magnetic field on skin tumorigenesis in SENCAR mice.
Carcinogenesis 1998;19(9):1617-21.
1998: DuBowski A; Johnston D A; Rupp T; Beltran L; Conti C J; DiGiovanni J
Papillomas at high risk for malignant progression arising both early and late during two-stage carcinogenesis in SENCAR mice.
Carcinogenesis 1998;19(6):1141-7.
1998: Kiguchi K; Beltrán L; Rupp T; DiGiovanni J
Altered expression of epidermal growth factor receptor ligands in tumor promoter-treated mouse epidermis and in primary mouse skin tumors induced by an initiation-promotion protocol.
Molecular carcinogenesis 1998;22(2):73-83.
1998: Bol D; Kiguchi K; Beltrán L; Rupp T; Moats S; Gimenez-Conti I; Jorcano J; DiGiovanni J
Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing the neu oncogene under the control of the bovine keratin 5 promoter.
Molecular carcinogenesis 1998;21(1):2-12.
1998: Stern M C; Gimenez-Conti I B; Budunova I; Coghlan L; Fischer S M; DiGiovanni J; Slaga T J; Conti C J
Analysis of two inbred strains of mice derived from the SENCAR stock with different susceptibility to skin tumor progression.
Carcinogenesis 1998;19(1):125-32.
1997: Angel J M; Beltrán L; Minda K; Rupp T; DiGiovanni J
Association of a murine chromosome 9 locus (Psl1) with susceptibility to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Molecular carcinogenesis 1997;20(2):162-7.
1997: Rundhaug J E; Gimenez-Conti I; Stern M C; Budunova I V; Kiguchi K; Bol D K; Coghlan L G; Conti C J; DiGiovanni J; Fischer S M; Winberg L D; Slaga T J
Changes in protein expression during multistage mouse skin carcinogenesis.
Molecular carcinogenesis 1997;20(1):125-36.
1997: Cai Y; Kleiner H; Johnston D; Dubowski A; Bostic S; Ivie W; DiGiovanni J
Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Carcinogenesis 1997;18(8):1521-7.
1997: Kiguchi K; Beltrán L; Dubowski A; DiGiovanni J
Analysis of the ability of 12-O-tetradecanoylphorbol-13-acetate to induce epidermal hyperplasia, transforming growth factor-alpha, and skin tumor promotion in wa-1 mice.
The Journal of investigative dermatology 1997;108(5):784-91.
1997: Bol D K; Kiguchi K; Gimenez-Conti I; Rupp T; DiGiovanni J
Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice.
Oncogene 1997;14(14):1725-34.
1997: Xian W; Rosenberg M P; DiGiovanni J
Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: possible role in mouse skin tumor promotion.
Oncogene 1997;14(12):1435-44.
1997: Baer-Dubowska W; Vulimiri S V; Harvey R G; Cortez C; DiGiovanni J
Analysis of 7-methylbenz[a]anthracene-DNA adducts formed in SENCAR mouse epidermis by 32P-postlabeling.
Carcinogenesis 1997;18(3):523-9.
1997: Cai Y; Baer-Dubowska W; Ashwood-Smith M; DiGiovanni J
Inhibitory effects of naturally occurring coumarins on the metabolic activation of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in cultured mouse keratinocytes.
Carcinogenesis 1997;18(1):215-22.
1996: Rho O; Bol D K; You J; Beltrán L; Rupp T; DiGiovanni J
Altered expression of insulin-like growth factor I and its receptor during multistage carcinogenesis in mouse skin.
Molecular carcinogenesis 1996;17(2):62-9.
1996: Cai Y; Baer-Dubowska W; Ashwood-Smith M J; Ceska O; Tachibana S; DiGiovanni J
Mechanism-based inactivation of hepatic ethoxyresorufin O-dealkylation activity by naturally occurring coumarins.
Chemical research in toxicology 1996;9(4):729-36.
1996: Baer-Dubowska W; Nair R V; Dubowski A; Harvey R G; Cortez C; DiGiovanni J
The effect of fluoro substituents on reactivity of 7-methylbenz[a]anthracene diol epoxides.
Chemical research in toxicology 1996;9(4):722-8.
1996: Battalora M S; Conti C J; Aldaz C M; Slaga T J; Johnston D A; DiGiovanni J
Regression and progression characteristics of papillomas induced by chrysarobin in SENCAR mice.
Carcinogenesis 1996;17(5):955-60.
1996: Min Z; Gill R D; Cortez C; Harvey R G; Loechler E L; DiGiovanni J
Targeted A --> T and G --> T mutations induced by site-specific deoxyadenosine and deoxyguanosine adducts, respectively, from the (+)-anti-diol epoxide of dibenz[a,j]anthracene in M13mp7L2.
Biochemistry 1996;35(13):4128-38.
1995: Xian W; Kiguchi K; Imamoto A; Rupp T; Zilberstein A; DiGiovanni J
Activation of the epidermal growth factor receptor by skin tumor promoters and in skin tumors from SENCAR mice.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1447-55.
1995: Battalora M S; Johnston D A; DiGiovanni J
The effects of calcium antagonists on anthrone skin tumor promotion and promoter-related effects in SENCAR mice.
Cancer letters 1995;98(1):19-25.
1995: Kiguchi K; Beltrán L M; You J; Rho O; DiGiovanni J
Elevation of transforming growth factor-alpha mRNA and protein expression by diverse tumor promoters in SENCAR mouse epidermis.
Molecular carcinogenesis 1995;12(4):225-35.
1995: Baer-Dubowska W; Nair R V; Cortez C; Harvey R G; DiGiovanni J
Covalent DNA adducts formed in mouse epidermis from dibenz[a,j]anthracene: evidence for the formation of polar adducts.
Chemical research in toxicology 1995;8(2):292-301.
1995: DiGiovanni J
Genetic factors controlling responsiveness to skin tumor promotion in mice.
Progress in clinical and biological research 1995;391():195-212.
1995: Slaga T J; DiGiovanni J; Winberg L D; Budunova I V
Skin carcinogenesis: characteristics, mechanisms, and prevention.
Progress in clinical and biological research 1995;391():1-20.
1994: Wang X J; Warren B S; Rupp T; Beltrán L M; DiGiovanni J
Loss of mouse epidermal protein kinase C isozyme activities following treatment with phorbol ester and non-phorbol ester tumor promoters.
Carcinogenesis 1994;15(12):2795-803.
1994: Rho O; Beltrán L M; Gimenez-Conti I B; DiGiovanni J
Altered expression of the epidermal growth factor receptor and transforming growth factor-alpha during multistage skin carcinogenesis in SENCAR mice.
Molecular carcinogenesis 1994;11(1):19-28.
1994: DiGiovanni J; Rho O; Xian W; Beltràn L
Role of the epidermal growth factor receptor and transforming growth factor alpha in mouse skin carcinogenesis.
Progress in clinical and biological research 1994;387():113-38.
1993: Battalora M S; Kruszewski F H; DiGiovanni J
Inhibition of chrysarobin skin tumor promotion in SENCAR mice by antioxidants.
Carcinogenesis 1993;14(12):2507-12.
1993: Cai Y; Bennett D; Nair R V; Ceska O; Ashwood-Smith M J; DiGiovanni J
Inhibition and inactivation of murine hepatic ethoxy- and pentoxyresorufin O-dealkylase by naturally occurring coumarins.
Chemical research in toxicology 1993;6(6):872-9.
1993: DiGiovanni J; Walker S E; Aldaz C M; Slaga T J; Conti C J
Further studies on the influence of initiation dose on papilloma growth and progression during two-stage carcinogenesis in SENCAR mice.
Carcinogenesis 1993;14(9):1831-6.
1993: Gill R D; Min Z; Cortez C; Harvey R G; Loechler E L; DiGiovanni J
Construction of Escherichia coli vectors containing deoxyadenosine and deoxyguanosine adducts from (+)-anti-dibenz[a,j]anthracene diol epoxide at a defined site.
Chemical research in toxicology 1993;6(5):681-9.
1993: Imamoto A; Wang X J; Fujiki H; Walker S E; Beltrán L M; DiGiovanni J
Comparison of 12-O-tetradecanoylphorbol-13-acetate and teleocidin for induction of epidermal hyperplasia, activation of epidermal PKC isozymes and skin tumor promotion in SENCAR and C57BL/6 mice.
Carcinogenesis 1993;14(4):719-24.
1993: DiGiovanni J; Bhatt T S; Walker S E
C57BL/6 mice are resistant to tumor promotion by full thickness skin wounding.
Carcinogenesis 1993;14(2):319-21.
1993: Wang X J; Warren B S; Beltrán L M; Fosmire S P; DiGiovanni J
Further identification of protein kinase C isozymes in mouse epidermis.
Journal of cancer research and clinical oncology 1993;119(5):279-87.
1993: DiGiovanni J; Beltrán L; Rupp A; Harvey R G; Gill R D
Further analysis of c-Ha-ras mutations in papillomas initiated by several polycyclic aromatic hydrocarbons and papillomas from uninitiated, promoter-treated skin in SENCAR mice.
Molecular carcinogenesis 1993;8(4):272-9.
1993: Gill R D; Rodriguez H; Cortez C; Harvey R G; Loechler E L; DiGiovanni J
Mutagenic specificity of the (+)anti-diol epoxide of dibenz[a,j]anthracene in the supF gene of an Escherichia coli plasmid.
Molecular carcinogenesis 1993;8(3):145-54.
1992: Nair R V; Nettikumara A N; Cortez C; Harvey R G; DiGiovanni J
Comparative metabolism of dibenz[a,j]anthracene and 7-methyldibenz[a,j]anthracene in primary cultures of mouse keratinocytes.
Chemical research in toxicology 1992;5(4):532-40.
1992: DiGiovanni J; Imamoto A; Naito M; Walker S E; Beltrán L; Chenicek K J; Skow L
Further genetic analyses of skin tumor promoter susceptibility using inbred and recombinant inbred mice.
Carcinogenesis 1992;13(4):525-31.
1992: Nair R V; Walker S E; Sharma P K; Witiak D T; DiGiovanni J
Mouse skin tumor initiating activity of fluorinated derivatives of 1,2,3,4-tetrahydro-7,12-dimethylbenz[a]anthracene.
Chemical research in toxicology 1992;5(2):153-6.
1992: Imamoto A; Beltrán L M; Fujiki H; Chenicek K J; DiGiovanni J
Enhanced induction of epidermal ornithine decarboxylase activity in C57BL/6 compared to DBA/2 mice by protein kinase C-activating skin tumor promoters: relevance to genetically mediated differences in promotion susceptibility.
Carcinogenesis 1992;13(2):177-82.
1992: DiGiovanni J
Multistage carcinogenesis in mouse skin.
Pharmacology & therapeutics 1992;54(1):63-128.
1992: Gill R D; Beltrán L; Nettikumara A N; Harvey R G; Kootstra A; DiGiovanni J
Analysis of point mutations in murine c-Ha-ras of skin tumors initiated with dibenz[a,j]anthracene and derivatives.
Molecular carcinogenesis 1992;6(1):53-9.
1991: DiGiovanni J; Walker S C; Beltran L; Naito M; Eastin W C
Evidence for a common genetic pathway controlling susceptibility to mouse skin tumor promotion by diverse classes of promoting agents.
Cancer research 1991;51(5):1398-405.
1991: Aldaz C M; Conti C J; Chen A; Bianchi A; Walker S B; DiGiovanni J
Promoter independence as a feature of most skin papillomas in SENCAR mice.
Cancer research 1991;51(3):1045-50.
1991: Nair R V; Gill R D; Nettikumara A N; Baer-Dubowska W; Cortez C; Harvey R G; DiGiovanni J
Characterization of covalently modified deoxyribonucleosides formed from dibenz[a,j]anthracene in primary cultures of mouse keratinocytes.
Chemical research in toxicology 1991;4(1):115-22.
1991: Nair R V; Fisher E P; Safe S H; Cortez C; Harvey R G; DiGiovanni J
Novel coumarins as potential anticarcinogenic agents.
Carcinogenesis 1991;12(1):65-9.
1991: Imamoto A; Beltrán L M; DiGiovanni J
Evidence for autocrine/paracrine growth stimulation by transforming growth factor-alpha during the process of skin tumor promotion.
Molecular carcinogenesis 1991;4(1):52-60.
1991: Gill R D; Butterworth B E; Nettikumara A N; DiGiovanni J
Relationship between DNA adduct formation and unscheduled DNA synthesis (UDS) in cultured mouse epidermal keratinocytes.
Environmental and molecular mutagenesis 1991;18(3):200-6.
1991: DiGiovanni J
Modification of multistage skin carcinogenesis in mice.
Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progrès de la recherche expérimentale des tumeurs 1991;33():192-229.
1990: Monks T J; Walker S E; Flynn L M; Conti C J; DiGiovanni J
Epidermal ornithine decarboxylase induction and mouse skin tumor promotion by quinones.
Carcinogenesis 1990;11(10):1795-801.
1990: Imamoto A; Beltrán L M; DiGiovanni J
Differential mechanism for the inhibition of epidermal growth factor binding to its receptor on mouse keratinocytes by anthrones and phorbol esters.
Carcinogenesis 1990;11(9):1543-9.
1990: Viaje A; Lu J Y; Hopkins N E; Nettikumara A N; DiGiovanni J; Alworth W L; Slaga T J
Inhibition of the binding of 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene to DNA in mouse skin epidermis by 1-ethynylpyrene.
Carcinogenesis 1990;11(7):1139-43.
1990: Baer-Dubowska W; Morris R J; Gill R D; DiGiovanni J
Distribution of covalent DNA adducts in mouse epidermal subpopulations after topical application of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene.
Cancer research 1990;50(10):3048-54.
1990: Hirabayashi N; Warren B S; Wang X J; Petersen-Marht S; Beltran L; Davis M M; Ashendel C L; DiGiovanni J
Partial characterization of epidermal protein kinase C in mice sensitive or resistant to phorbol ester.
Molecular carcinogenesis 1990;3(3):171-80.
1989: DiGiovanni J; Gill R D; Nettikumara A N; Colby A B; Reiners J J
Effect of extracellular calcium concentration on the metabolism of polycyclic aromatic hydrocarbons by cultured mouse keratinocytes.
Cancer research 1989;49(20):5567-74.
1989: Nair R V; Gill R D; Cortez C; Harvey R G; DiGiovanni J
Characterization of DNA adducts derived from (+/- )-trans-3,4-dihydroxy-anti-1,2-epoxy-1,2,3,4- tetrahydrodibenz[a,j]anthracene and (+/- )-7-methyl-trans-3,4-dihydroxy- anti-1,2-epoxy-1,2,3,4-tetrahydrodibenz[a,j]anthracene.
Chemical research in toxicology 1989;2(5):341-8.
1989: Ewing M W; Conti C J; Phillips J L; Slaga T J; DiGiovanni J
Further characterization of skin tumor promotion and progression by mezerein in SENCAR mice.
Journal of the National Cancer Institute 1989;81(9):676-82.
1989: Kruszewski F H; Naito M; Naito Y; DiGiovanni J
Histologic alterations produced by chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone) in SENCAR mouse skin: relationship to skin tumor promoting activity.
The Journal of investigative dermatology 1989;92(1):64-71.
1989: DiGiovanni J
Metabolism of polycyclic aromatic hydrocarbons and phorbol esters by mouse skin: relevance to mechanism of action and trans-species/strain carcinogenesis.
Progress in clinical and biological research 1989;298():167-99.
1989: Naito M; DiGiovanni J
Genetic background and development of skin tumors.
Carcinogenesis; a comprehensive survey 1989;11():187-212.
1988: Ewing M W; Conti C J; Kruszewski F H; Slaga T J; DiGiovanni J
Tumor progression in Sencar mouse skin as a function of initiator dose and promoter dose, duration, and type.
Cancer research 1988;48(24 Pt 1):7048-54.
1988: Kruszewski F H; DiGiovanni J
Alterations in epidermal polyamine levels and DNA synthesis following topical treatment with chrysarobin in SENCAR mice.
Cancer research 1988;48(22):6390-5.
1988: Sawyer T W; Gill R D; Smith-Oliver T; Butterworth B E; DiGiovanni J
Measurement of unscheduled DNA synthesis in primary cultures of adult mouse epidermal keratinocytes.
Carcinogenesis 1988;9(7):1197-202.
1988: Ewing M W; Crysup S E; Phillips J L; Slaga T J; DiGiovanni J
Enhancement of mezerein-promoted papilloma formation by treatment with 12-O-tetradecanoylphorbol-13-acetate or mezerein prior to initiation.
Carcinogenesis 1988;9(3):405-10.
1987: Sawyer T W; Fisher E P; DiGiovanni J
Skin tumor initiating activities of the 9- and 10-fluoro derivatives of 7- or 12-methylbenz[a]anthracene and the 9- and 10-trifluoromethyl derivatives of 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Carcinogenesis 1987;8(10):1465-8.
1987: Sawyer T W; Chang K; Harvey R G; DiGiovanni J
Further investigations into the effect of non-benzo ring bay-region methyl substituents on tumor-initiating activity of polycyclic hydrocarbons.
Cancer letters 1987;36(3):317-24.
1986: DiGiovanni J; Fisher E P; Sawyer T W
Kinetics of formation and disappearance of 7,12-dimethylbenz(a)anthracene:DNA adducts in mouse epidermis.
Cancer research 1986;46(9):4400-5.
1986: DiGiovanni J; Sawyer T W; Fisher E P
Correlation between formation of a specific hydrocarbon-deoxyribonucleoside adduct and tumor-initiating activity of 7,12-dimethylbenz(a)anthracene and its 9- and 10-monofluoroderivatives in mice.
Cancer research 1986;46(9):4336-41.

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